GCA_027662215.1 - 5 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

gnlProkkaCDHBOPON_1 (original name was: gnl|Prokka|CDHBOPON_1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1.1	lanthipeptide-class-ii	1	13,544

gnlProkkaCDHBOPON_8 (original name was: gnl|Prokka|CDHBOPON_8)

Region	Type	From	To	Most similar known cluster		Similarity
Region 8.1	NRPS	24,981	73,965	dipeptide aldehydes	NRP	41%

gnlProkkaCDHBOPON_15 (original name was: gnl|Prokka|CDHBOPON_15)

Region	Type	From	To	Most similar known cluster		Similarity
Region 15.1	ranthipeptide	23,450	45,038

gnlProkkaCDHBOPON_27 (original name was: gnl|Prokka|CDHBOPON_27)

Region	Type	From	To	Most similar known cluster		Similarity
Region 27.1	cyclic-lactone-autoinducer	18,954	34,345

gnlProkkaCDHBOPON_55 (original name was: gnl|Prokka|CDHBOPON_55)

Region	Type	From	To	Most similar known cluster		Similarity
Region 55.1	RRE-containing	1	2,868

Region	Type	From	To	Most similar known cluster	Similarity
Region 1.1	lanthipeptide-class-ii	1	13,544
Region 8.1	NRPS	24,981	73,965	dipeptide aldehydes	NRP	41%
Region 15.1	ranthipeptide	23,450	45,038
Region 27.1	cyclic-lactone-autoinducer	18,954	34,345
Region 55.1	RRE-containing	1	2,868

No secondary metabolite regions were found in these records:: gnlProkkaCDHBOPON_2 (original name was: gnl|Prokka|CDHBOPON_2); gnlProkkaCDHBOPON_3 (original name was: gnl|Prokka|CDHBOPON_3); gnlProkkaCDHBOPON_4 (original name was: gnl|Prokka|CDHBOPON_4); gnlProkkaCDHBOPON_5 (original name was: gnl|Prokka|CDHBOPON_5); gnlProkkaCDHBOPON_6 (original name was: gnl|Prokka|CDHBOPON_6); gnlProkkaCDHBOPON_7 (original name was: gnl|Prokka|CDHBOPON_7); gnlProkkaCDHBOPON_9 (original name was: gnl|Prokka|CDHBOPON_9); gnlProkkaCDHBOPON_10 (original name was: gnl|Prokka|CDHBOPON_10); gnlProkkaCDHBOPON_11 (original name was: gnl|Prokka|CDHBOPON_11); gnlProkkaCDHBOPON_12 (original name was: gnl|Prokka|CDHBOPON_12); gnlProkkaCDHBOPON_13 (original name was: gnl|Prokka|CDHBOPON_13); gnlProkkaCDHBOPON_14 (original name was: gnl|Prokka|CDHBOPON_14); gnlProkkaCDHBOPON_16 (original name was: gnl|Prokka|CDHBOPON_16); gnlProkkaCDHBOPON_17 (original name was: gnl|Prokka|CDHBOPON_17); gnlProkkaCDHBOPON_18 (original name was: gnl|Prokka|CDHBOPON_18); gnlProkkaCDHBOPON_19 (original name was: gnl|Prokka|CDHBOPON_19); gnlProkkaCDHBOPON_20 (original name was: gnl|Prokka|CDHBOPON_20); gnlProkkaCDHBOPON_21 (original name was: gnl|Prokka|CDHBOPON_21); gnlProkkaCDHBOPON_22 (original name was: gnl|Prokka|CDHBOPON_22); gnlProkkaCDHBOPON_23 (original name was: gnl|Prokka|CDHBOPON_23); gnlProkkaCDHBOPON_24 (original name was: gnl|Prokka|CDHBOPON_24); gnlProkkaCDHBOPON_25 (original name was: gnl|Prokka|CDHBOPON_25); gnlProkkaCDHBOPON_26 (original name was: gnl|Prokka|CDHBOPON_26); gnlProkkaCDHBOPON_28 (original name was: gnl|Prokka|CDHBOPON_28); gnlProkkaCDHBOPON_29 (original name was: gnl|Prokka|CDHBOPON_29); gnlProkkaCDHBOPON_30 (original name was: gnl|Prokka|CDHBOPON_30); gnlProkkaCDHBOPON_31 (original name was: gnl|Prokka|CDHBOPON_31); gnlProkkaCDHBOPON_32 (original name was: gnl|Prokka|CDHBOPON_32); gnlProkkaCDHBOPON_33 (original name was: gnl|Prokka|CDHBOPON_33); gnlProkkaCDHBOPON_34 (original name was: gnl|Prokka|CDHBOPON_34); gnlProkkaCDHBOPON_35 (original name was: gnl|Prokka|CDHBOPON_35); gnlProkkaCDHBOPON_36 (original name was: gnl|Prokka|CDHBOPON_36); gnlProkkaCDHBOPON_37 (original name was: gnl|Prokka|CDHBOPON_37); gnlProkkaCDHBOPON_38 (original name was: gnl|Prokka|CDHBOPON_38); gnlProkkaCDHBOPON_39 (original name was: gnl|Prokka|CDHBOPON_39); gnlProkkaCDHBOPON_40 (original name was: gnl|Prokka|CDHBOPON_40); gnlProkkaCDHBOPON_41 (original name was: gnl|Prokka|CDHBOPON_41); gnlProkkaCDHBOPON_42 (original name was: gnl|Prokka|CDHBOPON_42); gnlProkkaCDHBOPON_43 (original name was: gnl|Prokka|CDHBOPON_43); gnlProkkaCDHBOPON_44 (original name was: gnl|Prokka|CDHBOPON_44); gnlProkkaCDHBOPON_45 (original name was: gnl|Prokka|CDHBOPON_45); gnlProkkaCDHBOPON_46 (original name was: gnl|Prokka|CDHBOPON_46); gnlProkkaCDHBOPON_47 (original name was: gnl|Prokka|CDHBOPON_47); gnlProkkaCDHBOPON_48 (original name was: gnl|Prokka|CDHBOPON_48); gnlProkkaCDHBOPON_49 (original name was: gnl|Prokka|CDHBOPON_49); gnlProkkaCDHBOPON_50 (original name was: gnl|Prokka|CDHBOPON_50); gnlProkkaCDHBOPON_51 (original name was: gnl|Prokka|CDHBOPON_51); gnlProkkaCDHBOPON_52 (original name was: gnl|Prokka|CDHBOPON_52); gnlProkkaCDHBOPON_53 (original name was: gnl|Prokka|CDHBOPON_53); gnlProkkaCDHBOPON_54 (original name was: gnl|Prokka|CDHBOPON_54); gnlProkkaCDHBOPON_56 (original name was: gnl|Prokka|CDHBOPON_56); gnlProkkaCDHBOPON_57 (original name was: gnl|Prokka|CDHBOPON_57); gnlProkkaCDHBOPON_58 (original name was: gnl|Prokka|CDHBOPON_58); gnlProkkaCDHBOPON_59 (original name was: gnl|Prokka|CDHBOPON_59); gnlProkkaCDHBOPON_60 (original name was: gnl|Prokka|CDHBOPON_60); gnlProkkaCDHBOPON_61 (original name was: gnl|Prokka|CDHBOPON_61); gnlProkkaCDHBOPON_62 (original name was: gnl|Prokka|CDHBOPON_62); gnlProkkaCDHBOPON_63 (original name was: gnl|Prokka|CDHBOPON_63); gnlProkkaCDHBOPON_64 (original name was: gnl|Prokka|CDHBOPON_64); gnlProkkaCDHBOPON_65 (original name was: gnl|Prokka|CDHBOPON_65); gnlProkkaCDHBOPON_66 (original name was: gnl|Prokka|CDHBOPON_66); gnlProkkaCDHBOPON_67 (original name was: gnl|Prokka|CDHBOPON_67); gnlProkkaCDHBOPON_68 (original name was: gnl|Prokka|CDHBOPON_68); gnlProkkaCDHBOPON_69 (original name was: gnl|Prokka|CDHBOPON_69); gnlProkkaCDHBOPON_70 (original name was: gnl|Prokka|CDHBOPON_70); gnlProkkaCDHBOPON_71 (original name was: gnl|Prokka|CDHBOPON_71); gnlProkkaCDHBOPON_72 (original name was: gnl|Prokka|CDHBOPON_72); gnlProkkaCDHBOPON_73 (original name was: gnl|Prokka|CDHBOPON_73); gnlProkkaCDHBOPON_74 (original name was: gnl|Prokka|CDHBOPON_74); gnlProkkaCDHBOPON_75 (original name was: gnl|Prokka|CDHBOPON_75); gnlProkkaCDHBOPON_76 (original name was: gnl|Prokka|CDHBOPON_76); gnlProkkaCDHBOPON_78 (original name was: gnl|Prokka|CDHBOPON_78); gnlProkkaCDHBOPON_89 (original name was: gnl|Prokka|CDHBOPON_89)

Compact view

gnlProkkaCDHBOPON_1 - Region 1 - lanthipeptide-class-ii

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Location: 1 - 13,544 nt. (total: 13,544 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

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core biosynthetic genes

additional biosynthetic genes

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Gene details

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Gene overview

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

Lanthipeptide predictions

Lanthipeptide(s) for ctg1_3

ctg1_2

Leader:

MTEEFIGCIEEELKEIELFYEENGVEVEAYTLHNG

Core:

SFFSICC

Core with dehydrations:

DhaFFDhaICysCys

antiSMASH-DB 4.0 matches for ctg1_2

100.0% NZ_JADPAT010000014.1and 2 others:

NZ_JAQDKC010000001.1 Lanthipeptides: PGQ53_RS00010_lanthipeptideNZ_QUIY01000001.1 Lanthipeptides: allorf_008439_008567_lanthipeptide

Lanthipeptides: allorf_07424_07552_lanthipeptide

1

SFFSICC

7

SFFSICC

1

SFFSICC

7

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

ctg1_2 - Class II: Cleavage pHMM score: -6.60; RODEO score: 0; Monoisotopic mass: 769.3 Da; Molecular weight: 769.9 Da; Number of bridges: 2

gnlProkkaCDHBOPON_8 - Region 1 - NRPS

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Location: 24,981 - 73,965 nt. (total: 48,985 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

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NRPS/PKS domains

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

Selected features only

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Similar known gene clusters from MIBiG 3.1

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 24980 - 73965:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - X - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg8_47

AMP-binding (20..419): X

nrpys: Leu, Trp

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVLTDGGISK
Nearest Stachelhaus code(s):: Leu or Trp DVLTDGGISK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1033..1421): X

nrpys: Leu, Trp

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAMFSGAIFK
Nearest Stachelhaus code(s):: Leu or Trp DAMFSGAIFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2027..2418): X

nrpys: Leu, Trp

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAITTGGVSK
Nearest Stachelhaus code(s):: Leu or Trp DAITTGGVSK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

gnlProkkaCDHBOPON_15 - Region 1 - ranthipeptide

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Location: 23,450 - 45,038 nt. (total: 21,589 nt) Show pHMM detection rules used

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

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core biosynthetic genes

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Gene overview

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaCDHBOPON_27 - Region 1 - cyclic-lactone-autoinducer

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Location: 18,954 - 34,345 nt. (total: 15,392 nt) Show pHMM detection rules used

Region on contig edge.

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

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Gene overview

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
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Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaCDHBOPON_55 - Region 1 - RRE-containing

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Location: 1 - 2,868 nt. (total: 2,868 nt) Show pHMM detection rules used

Region on contig edge.

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

Gene overview

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.