LOCUS       gnlProkkaHCIBMOPF_24   10614 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HCIBMOPF_24.
ACCESSION   gnlProkkaHCIBMOPF_24
VERSION     gnlProkkaHCIBMOPF_24
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 13:57:39
            Original ID  :: gnl|Prokka|HCIBMOPF_24
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10614
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10614
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[326:614]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      327..614
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..10614
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10614
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             327..614
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg24_1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.3e-09,
                     bitscore: 27.8, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.8e-13, bitscore: 40.4,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLKDDVVVMKKNCLEDDIEKVKVILGKDEKSIFRLNETAKFIWDN
                     CNGRRISEISTLLFDACVNKESLDIDVISEDCREIISMLLDNDLIEIKEV"
     CDS             621..1667
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg24_2"
                     /sec_met_domain="PF04055 (E-value: 1.6e-27, bitscore: 86.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 5.6e-15, bitscore: 45.5,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKASEQIKITGLYIELTSQCNLRCLHCYNESGVSTHRIDVESFQ
                     NIIKDIENPAGVSVTLSGGEPLLHPDLWKFIEILYQKGFGQILIITNATLVTKEVAEKL
                     KKYGVSVQVSLNGSCADIHDQLCGKGNFDKTLTGLKTLKAAGINRILVRYMLAKFNSED
                     LIEFLTLMKNIGITHIDIAILTVLGRSKDNLEKLYLPDIERDKIVQMYKKDSRVKSYIE
                     SGMEVKFPEGTTIGCPYLNSMADEIPITPRISADGLVHFCQLFSDEKYAVGSIKESNTV
                     DIFKSNQCNELIDFFRLGVKYMNGCDKCVWKSSCGRGCIALCVSNGSIQETDGNCYLRK
                     KQLLSDLK"
     CDS             1681..1902
                     /locus_tag="ctg24_3"
                     /transl_table=11
                     /translation="MSLITVRMHSKERTYGGRNMEYTKPVITKNELEVDAQGSARSCGS
                     FKCTSSNFNCNNYDCTKGGHKFNCNSGW"
     CDS             2040..3707
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 156.4; E-value:
                     1.7e-47)"
                     /gene_kind="transport"
                     /locus_tag="ctg24_4"
                     /transl_table=11
                     /translation="MRIYKWLFNEITKLSVKYTVILALLIIVQNIMKPLVLLVYQYIAS
                     NDITIVLISVGVLFLVYIIKEIANNFADVITVKYSNLVEIHLLRRLYNSVANKNILLLN
                     DAEYVLKLQRARCFIESSSLNFYRIAIVLICEIIETVFSAIIIGRISLLFMLLFLVMSL
                     INNCTLKKYNSDLVRIHKEQDVNLRKQNYFSELLQNKIYEKEIRINKLFSWLENKREKY
                     FKSTEMEHRKFSEKWSKINFLISFILHLIETGVVILAVYLLSVGRFSLGDVVALITGQS
                     TIVGSVSQIIKSYSFFKQQEYQAKNLYELLHEDRSKNIELKKEEGFLRLENISFRYADK
                     NNIDNLSLELKQGEKIALVGSNGSGKSTLIGIILGLYKPTSGKVSVNADMTAIFQDFAR
                     LQDLLKVNINMGDIFNEKNTEKMNSLLEQSFIDLGIFPLGLDTMLSKEYGGIDLSLGQW
                     QKIALCRALYKKADVVIFDEPTSSLDPLEEKRQFETAFKLLKDKTVIIITHRVGITNYA
                     DRILFMDDGKIVEEGTQEQLLNRRGKFYELYDSQRKWY"
     CDS             3720..5468
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 161.7; E-value:
                     3.8e-49)"
                     /gene_kind="transport"
                     /locus_tag="ctg24_5"
                     /transl_table=11
                     /translation="MKKTVQFILEIQKILDKKTWIKVKLFYLAVLLSAIFEPIVLVLYK
                     NLLNMLSNQVAFASTIFWVVFGYEFVQLLSGFSMLLIGHEKLKLEYTLNNILIKAVHNK
                     LNRICEEEFEKENTYNLLERVKESFVNSVLSIIDGLIGGATQIIQCVGCVLIVTRINLY
                     LGLAMILANIPYIIVNIVYNIKEYKIKQKCSLKKRQVSYYEEQLQYRRNAKDIRLFNAT
                     PYMLNRIENLKTDITKEYVMLYNKEVWLKSATTILKFVVTGLCIILCIKPTYYGTANCG
                     DIVVLITASLNLENKIFELFENYYLIMNCGFIIEDWYSFSELPEEKEIKSNDTIENYSI
                     TFRNVSFKYPGTNRYALQGVNLHIKQGEKIVIIGENGSGKTTFINLLLGCFSSYTGNIL
                     IDGKEICNVYDEIRRNCSVVFQDFLKLQLSIKDNIFLEQSSLFEEKQIEEQVYFIGNLK
                     NGINTVLGQLEEGGIELSGGEWQLIAILRAMVKTNKKIIVMDEPTSYLDSKKEDWFYTT
                     LLEIPKDMTVIIVSHRLSVAKLCDRIVLFKKGRIETMGTHEELIENSEEYKRMYFSQKD
                     MYDINS"
     CDS             5706..6374
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 223.5; E-value: 4.2e-68)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg24_6"
                     /transl_table=11
                     /translation="MQKILVVEDDRDIQELLQEFLKEAGYMIDVAVDGVEAITMFNTNS
                     YDLILLDIMLPKITGYSVCELIRKQSQIPIIMLTALDSESDQVKGLDLQADDYITKPFS
                     MPILLRKIAAVLRRSNRNSDDNVSIHYKDLILDLDGYKVYIKNVEYDLTQREFEVLREL
                     LYHQGKVLSRQYILNTLWKYDFYGDERVVDTHIKNLRKKLNIDYIETIRGVGYKIEKEM
                     "
     CDS             6376..7782
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 169.6; E-value: 2.4e-51)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg24_7"
                     /transl_table=11
                     /translation="MVIKIFAITCLLMIICSSATYGFIAWLVPKTYSTDLDVQLNKNVN
                     ILISELERTSGKQSGFLFDEFLLNNDVILQLFDEDNQEIAVPSQYNQVFPSVIDGNAIV
                     YESDEASYRATHSYLFAFNDSKIIYTLCVTGDSQPVNQLINTIDSIAPILMIVIILISI
                     VDAVFFSIYVTRPVIEISKVSKRMSELDFTWCCNEKRNDELGILAHSLNEMSQKLSLAL
                     HDLQTANSQLKEDINRERKLEQNQLDFFSAVSHELKTPITVIKGQLEGMLLNVGKYKER
                     DKYLARSLEVVKSMEGMVQEILTISRIKSSGVILHYENFDLSEIIKEEYSLFEDIIIKR
                     QLRWHEDIQKGLMIIGDRMLLNKVINNLVSNAVQYSPCGEEVFVSACNIEGNIQFVIEN
                     TGVSLSDNDIPQIFNAFYRVEPSRNRQTGGSGLGLYIVKMILEQHQAKYQIENSALGVC
                     FTINFEKKVN"
     CDS             7902..8654
                     /locus_tag="ctg24_8"
                     /transl_table=11
                     /translation="MKNFKLKGILIASGLICVCALAGCATSNNTDQQNSALVSEPSVMS
                     KAEKDSLTAETPGESVDYAVYEQYGLIYDEQNGWYTYNENVVRFFNDPVAGASFTNFFT
                     GTVDIEAKRDENKELIGIEECSQETYDSHTKKYAKFANMSSSALPSTIQYETTQNSEEW
                     LKDYETYGIAYNKSDNSWYYNSEKIQILIDSEKAIVYSTDEDGVCLAVSRGDNHEITEI
                     KVISLNDAQLLLQANNPGKVLDSTMEEN"
     CDS             complement(8727..9125)
                     /locus_tag="ctg24_9"
                     /transl_table=11
                     /translation="MAINKHHIYFIWQVNFENNIPFVTIKITDKNLINSSPLFRQFQRK
                     ITFFKIFGTTRCPNITGNIVAIYKKFLPYLPERHGGFYRSSDERKSERVTVRLLYAIGL
                     IVIDHYFPINMKRRMDCNLFPCAFLLLF"
     CDS             9219..9617
                     /locus_tag="ctg24_10"
                     /transl_table=11
                     /translation="MTENRIRELRKSHNMSQEALGAVINTTQQAVSKMEKDICFISTDL
                     LISMAEYFNVTTDYILGLSDIKRDLSGQFRMNQEMDQCYDIVLRYRNLSDINQKTLRCV
                     LKRLEQAQLEEIELCTKEVKTNAEDSCM"
     CDS             9595..10335
                     /locus_tag="ctg24_11"
                     /transl_table=11
                     /translation="MLRIAVCDDDLKFTGDFETLVLQESRNMGIRVETDVFSDGDTLVK
                     SILSGERYNLIFLDIEMKQVDGISAARCIREIDRSVLLIYISGYDQYLKELFEVEPFRF
                     LSKPVNDNKFCRYFREACQRIGETEVFYQFTFNKEIKKVPLKDIVYFESRNRMVYIYFR
                     DNSFEHFYGKLNDVEKELTNSRQYFLRTHQSFLVNYDYIKKMNFFNVTVSIGGKEIELK
                     ISEDRQKEVRRQLCEIAGGKAVVE"
ORIGIN
        1 attgggagct ctctcacaac tatacaatgt aaacgaatta caacatattt cgtaagtggt
       61 aattaataaa catcaatatt tatttagagt atgaaattta tagaatttca atattcggga
      121 aaaattacat ttaaatttgc tttttcaacg gaaagaaagt gttagaaatt taaaggcata
      181 taatcatatt taaatattcg acaaataata gtttggttcg ttattaattt gtatgttagg
      241 taattatcga ggaaaactgc aaattcgtat aattaacgaa tgtacttatt tatttgaaat
      301 gaagaagcaa aggaggaaca aatcaaatgc ttaaagatga tgttgttgtg atgaaaaaaa
      361 attgccttga agatgatata gaaaaagtaa aggtgatttt gggaaaggat gaaaaaagca
      421 tttttaggct gaatgaaact gcaaagttta tttgggataa ctgtaacgga agaaggattt
      481 ctgaaatctc gaccttgcta tttgacgctt gcgtaaacaa ggaatctctg gatattgatg
      541 ttattagtga agattgtaga gagataatat caatgctttt agataatgac ttgatagaaa
      601 taaaggaggt gtaagcggaa atgaaaaaag catctgaaca gattaagatt acaggactgt
      661 atatcgaact tacatcccag tgtaatttaa gatgtttaca ttgttataat gagtcaggag
      721 tttctacgca taggattgat gtagagtcat ttcaaaatat aataaaagat attgagaatc
      781 ctgcgggtgt tagcgtaact ttatctggcg gagaaccatt attgcatcct gatttatgga
      841 aatttattga aattctttat cagaaaggat ttggtcaaat tttgattata actaatgcga
      901 ctttagtaac gaaagaagtg gctgaaaaat taaaaaaata tggcgtatca gtgcaggtaa
      961 gtttaaatgg ttcttgtgcc gatatacatg atcaactgtg tggaaaggga aattttgata
     1021 aaaccctcac aggattgaaa acattaaaag ctgcaggtat taataggatt ttggttagat
     1081 atatgctggc caaatttaac tcagaggatt tgattgaatt cttgacgtta atgaaaaaca
     1141 ttggaattac acatatagac atagcaatat taaccgttct tggacgttca aaagataatt
     1201 tggaaaagct atatttgcca gatatagaac gtgacaagat agttcaaatg tacaaaaaag
     1261 atagcagggt aaaaagctac atagagtcag ggatggaagt gaagttcccg gagggtacaa
     1321 caattgggtg cccatatttg aatagtatgg cagatgagat accgattact cctcgtatat
     1381 cagcagatgg attggtacat ttttgccagt tgttttcaga cgaaaagtat gctgtaggca
     1441 gtattaagga aagtaatact gtggatattt ttaaatcgaa ccaatgtaat gaattaattg
     1501 attttttcag gctcggtgtg aaatatatga atggatgcga taaatgtgta tggaaatctt
     1561 cttgtggaag aggatgcatt gctttatgtg tgagtaatgg ttcaatacaa gaaacggatg
     1621 gtaattgtta tttgcgaaaa aaacaattgc tttctgattt gaaataataa aggttataag
     1681 atgagcttaa tcactgtacg aatgcattca aaagaaagaa catatggagg tagaaacatg
     1741 gaatatacaa aacctgtaat aacaaagaat gaactcgaag tcgatgcaca gggatctgca
     1801 agaagttgtg gatcattcaa gtgtacatca agtaacttta actgcaacaa ttatgactgt
     1861 acgaaaggcg gacacaaatt taactgcaac tctggctggt aaaatatagt ttgccgttcc
     1921 gagggaattt tatacatttt ataatatagc gttagtatag tgattaggca taattccctg
     1981 aatataaggg cttttccaat ggaaaagtcc ttattaaagt taagggagat tggagaatta
     2041 tgagaattta taaatggcta tttaatgaaa ttactaaatt atcagtcaaa tatacagtta
     2101 tcttggcatt gctaattata gttcaaaaca ttatgaaacc tttagtgttg ttggtttatc
     2161 aatatatagc ttcaaatgat ataacaatag tattgatttc tgttggagtt ctttttttgg
     2221 tttatataat taaagaaatt gcgaataatt ttgcagacgt aataactgta aagtatagta
     2281 atctggtaga aatacatcta ttaagacgat tatataatag tgttgcaaat aaaaatatat
     2341 tgttgttaaa tgatgcagaa tacgtattga agttacaaag agctaggtgc tttattgaat
     2401 cttcaagtct taatttttat aggatagcga ttgtattaat atgtgaaatt atagaaactg
     2461 ttttttcggc aataattatt ggaagaataa gccttttgtt tatgctatta tttttagtta
     2521 tgagtttaat aaataattgc accttaaaaa agtataatag tgatttagtt aggatacaca
     2581 aagaacaaga tgtaaattta agaaaacaaa attatttttc tgaattatta caaaataaga
     2641 tttacgaaaa agaaattaga attaataaat tattttcatg gttagaaaat aaacgagaaa
     2701 agtattttaa atctactgaa atggaacata gaaaattctc tgaaaagtgg agtaagatta
     2761 attttttgat ttcatttata cttcacttga tagaaactgg agtagtaatt ttggcggttt
     2821 atttactttc tgttggtcga ttttctttag gggatgttgt tgctctgata acagggcagt
     2881 cgacaattgt aggttctgtt tcacaaataa taaaaagcta ttcatttttt aagcaacaag
     2941 aatatcaggc aaaaaattta tatgagttac tccatgagga tagaagtaaa aatatcgaac
     3001 tgaaaaaaga agaaggattt ttgagattag aaaatatcag ttttcgatat gctgataaaa
     3061 acaatataga taatttatca ttagaattaa aacaaggtga aaagattgct ctggttggct
     3121 ctaatggttc cggtaagagt acgcttatag gaattattct tggactatac aaaccaacaa
     3181 gtggaaaagt aagtgttaat gcagatatga cagcaatttt tcaggatttt gcaaggttgc
     3241 aagatttatt aaaggttaat ataaatatgg gtgatatttt caatgaaaag aatacagaga
     3301 agatgaacag tctgttagaa caatcgttta tagatttggg tatttttcct ctagggttag
     3361 atacaatgtt atctaaagaa tatggcggta tagatttatc gttaggacag tggcagaaaa
     3421 tagcattatg tagagcgtta tataaaaagg ctgatgtagt aatatttgat gagccgactt
     3481 cttcacttga tccattggaa gaaaagagac aatttgaaac agcgtttaaa ttattaaaag
     3541 ataaaaccgt tattattatt actcatagag tgggaattac aaattatgcg gatagaattt
     3601 tatttatgga tgacgggaag attgtagagg aagggacgca ggaacaatta ttgaatagga
     3661 gaggtaaatt ctacgaatta tatgattctc aaagaaagtg gtattagtag gaggctatta
     3721 tgaaaaaaac agtgcagttc attcttgaaa ttcaaaaaat attggataag aaaacttgga
     3781 ttaaagtgaa actattttat ttagcagtct tattaagtgc catttttgaa cctattgtat
     3841 tagttttata caaaaattta ttgaatatgc tatctaatca agtagcattt gcaagcacta
     3901 ttttttgggt cgtattcgga tatgagttcg tgcaattact ttctggtttc tctatgttgt
     3961 taattgggca tgaaaaatta aaattagaat atacgctgaa caatattttg ataaaagcag
     4021 ttcataataa gttaaaccga atatgtgaag aagaatttga aaaagaaaat acttataatc
     4081 ttttggaaag agtaaaagag agttttgtaa atagtgtatt gagtattata gatggtttaa
     4141 taggaggtgc tactcaaata atacaatgtg ttggctgtgt actaattgtc actaggataa
     4201 atttgtattt gggattagca atgatattgg caaatattcc atatataatt gttaatatag
     4261 tatataatat taaggaatat aaaataaaac aaaagtgtag tttgaaaaaa aggcaagtat
     4321 cttattacga agaacaatta caatatagga gaaatgctaa agacataagg ttatttaatg
     4381 ctactccata tatgttgaat agaatagaaa atcttaaaac agatattact aaagaatacg
     4441 taatgttata taacaaagaa gtatggctca aatcagcaac aacaatatta aaatttgttg
     4501 ttactggatt atgtattata ttatgtatca aacccactta ttatggtaca gcaaattgtg
     4561 gtgatattgt tgttcttatt acggcttctt tgaatttgga aaataaaata tttgaattat
     4621 tcgagaatta ttatttgata atgaattgtg ggtttataat tgaagattgg tatagttttt
     4681 cggaattacc tgaagagaaa gaaataaaat caaatgatac tatagaaaat tattctataa
     4741 cattcagaaa tgtatccttc aaatatcccg gaacaaacag atatgcattg caaggggtta
     4801 atttacatat taagcaaggt gagaagattg ttattatagg tgaaaatgga agtggaaaaa
     4861 caacttttat aaatttattg cttggttgct tttcatcata tactggaaat atacttatag
     4921 atggaaagga aatatgtaat gtatatgatg aaataagaag aaactgctct gtggtatttc
     4981 aagatttctt aaaattgcaa ttatcaatca aagacaatat atttttagaa cagtcatctt
     5041 tgtttgagga aaagcaaatt gaagaacagg tatattttat aggtaattta aaaaatggaa
     5101 tcaatacagt tcttgggcaa cttgaggaag gtggtattga attgtctgga ggtgaatggc
     5161 agctcatcgc tatattgagg gctatggtaa aaacaaataa aaaaataatt gttatggatg
     5221 aaccgacctc atatttagat tcaaaaaagg aggactggtt ttatacgaca ttgttggaga
     5281 taccaaaaga tatgacggtg ataattgttt cccatcgcct aagtgtagca aaattatgtg
     5341 acagaatagt tctatttaag aagggcagaa tagaaacaat gggaacgcat gaagagttga
     5401 ttgaaaattc tgaggaatat aaaagaatgt attttagtca aaaagatatg tatgatatta
     5461 attcataaag taataaagga attgtaataa aattaaaggg gtgttgcact gcttgtgaac
     5521 agctcctttt ttgtataaaa aatagtcagg ctcgtatcaa acgtatactg gtagaaatat
     5581 cagaacgtta tgtgagacgg tgtaaacggt tggtagataa aataattatt taaccaattt
     5641 catttttgtg tgaaaacaca cagaacacaa aaaagtatga tatgatattt aaggaggtaa
     5701 tatttatgca aaaaatttta gttgttgaag atgataggga tattcaggaa ttattacaag
     5761 agtttttaaa agaggcaggt tatatgattg atgttgcagt agatggcgta gaagcgatta
     5821 ctatgtttaa tacaaattca tatgacttga ttttattgga tattatgtta cccaaaatta
     5881 cagggtatag tgtctgcgaa ctgatacgca aacaatcaca aatcccgatt attatgctta
     5941 ctgctttaga tagtgaaagt gatcaggtaa aaggattgga tttgcaagcg gatgattata
     6001 ttacaaaacc cttttctatg cccatattgc tacgaaaaat agctgccgtt ttacgccgct
     6061 ctaatagaaa tagtgacgat aatgtttcta tacattataa ggatttaatt ttggatttag
     6121 atggttataa ggtttatatc aaaaatgtag aatatgattt aacacaaaga gaatttgaag
     6181 tgcttagaga attactctat catcaaggaa aggttctttc tcggcagtac attcttaata
     6241 cattatggaa atatgatttt tatggagatg aacgtgtagt tgatacacat ataaaaaatc
     6301 ttcgtaaaaa actaaatatt gattatatag aaacaataag aggagtggga tataaaattg
     6361 agaaggaaat gtagtttggt tattaaaatt tttgcgataa cctgtttatt gatgataatt
     6421 tgtagctcgg ctacgtatgg gtttattgcg tggttagttc ctaaaacata tagtacagat
     6481 ttggatgtgc aactgaataa gaacgtaaac attttaatat ctgaattgga gagaacgtca
     6541 ggaaaacaga gtggatttct gtttgatgag tttttattaa ataatgatgt gattttacag
     6601 ttgtttgatg aggataatca ggagattgcg gttccttcac agtataatca ggtttttccg
     6661 agtgttattg atggtaacgc tatagtttat gaaagcgatg aagcttctta tcgtgcaaca
     6721 catagttatc tttttgcttt taatgattct aaaataatct atactttatg tgtgacaggt
     6781 gattcacagc cagtcaacca gttaataaac acaatcgata gtatagctcc aatattgatg
     6841 attgtaatta tcttgatttc aattgtagac gcagtatttt tttctatcta tgttacaaga
     6901 cctgttattg aaattagtaa ggtatcaaag agaatgtctg agcttgattt tacatggtgt
     6961 tgtaacgaaa aacgtaatga tgaattagga atattggcac atagtttaaa tgaaatgtca
     7021 caaaaattat cattggcatt acatgattta caaacagcca acagtcaatt aaaagaagat
     7081 attaatcgtg aacgcaagtt agagcaaaac caacttgatt ttttttctgc tgtatcacat
     7141 gaattaaaaa cacccattac agttattaaa gggcaacttg aaggtatgtt gcttaatgtt
     7201 ggaaaatata aagaacgtga taaatatctt gctcgttctt tggaagtggt aaaatcaatg
     7261 gaaggaatgg tacaagaaat tttaacaatt tctcgtatta aatcatcagg agttatcctt
     7321 cattatgaaa actttgactt atcagagata ataaaagagg agtatagttt atttgaagat
     7381 attattatta aaagacagtt gagatggcac gaggatatac aaaagggatt aatgattatt
     7441 ggtgatagaa tgcttttaaa taaagttata aataatcttg tgtctaatgc agtccagtat
     7501 tcaccatgtg gagaggaggt ttttgtttca gcttgcaata tagaaggaaa tatacagttt
     7561 gttatagaga atacaggtgt aagtctttca gataatgata tacctcaaat ttttaatgct
     7621 ttctatcgtg tggaaccgtc acgtaatcga cagacagggg gaagtggatt ggggctatat
     7681 attgtaaaaa tgattttgga acaacatcaa gcaaagtacc agatagagaa ttcggcgttg
     7741 ggtgtatgtt ttacaataaa ttttgaaaaa aaagtcaatt aagaaagttt gtttgtcact
     7801 tcaatttttg caactacaca taaaacatac aatttccaca ataaaacacc atatacgttt
     7861 gttaaaatat aaatatcaaa atttggaagg agagatattc aatgaaaaat tttaaactta
     7921 aaggtatttt aattgcttca gggttaatct gtgtatgtgc tttggcagga tgtgcaacaa
     7981 gtaataatac tgatcagcag aacagtgctt tagtgtctga accgtcagtt atgtcaaagg
     8041 cagaaaaaga ctctttaaca gcggaaacgc cgggggaaag tgttgactat gctgtgtatg
     8101 aacagtatgg cttgatttat gatgaacaga acggttggta tacctataac gaaaatgtag
     8161 tgcgattttt caatgatcca gtagcaggtg caagcttcac aaattttttt acaggaacag
     8221 tagacattga agcaaaacgt gatgaaaata aagagcttat aggtattgag gagtgttctc
     8281 aggaaacata tgatagccac acaaaaaaat atgcaaaatt tgcaaatatg tcatcatctg
     8341 cactgccaag cactatacaa tatgaaacaa cacagaatag tgaagagtgg ctaaaggatt
     8401 acgagacata tggaattgcc tataacaaat cagataatag ttggtattat aatagtgaga
     8461 agatacagat attaattgac agtgaaaaag cgattgtcta ttcaactgat gaagatggtg
     8521 tatgtcttgc agtttccaga ggcgataacc atgaaataac tgaaatcaaa gtaatttctc
     8581 taaatgatgc acaattgttg ttacaggcta ataatccggg taaagtgctt gactcaacaa
     8641 tggaagagaa ttaaaaaaaa tattttttgt cggttttact taaagctgag gttatgcatt
     8701 tagtataatc ggaaaacaat ttagtatcaa aataatagta aaaaggcgca tggaaataaa
     8761 ttgcaatcca tgcgcctttt catgtttata ggaaaataat gatcgataac aattagacca
     8821 atggcgtaga gcagccttac ggtgactcgt tcgcttttcc tttcatcact actgcggtag
     8881 aacccaccat gcctttcagg caaatatggt aaaaattttt tataaattgc cacgatattc
     8941 cctgtaatat tagggcagcg cgttgtacca aagattttga aaaatgtgat ttttctttga
     9001 aattgacgga atagtggact gctgtttatc aaatttttat ccgttatttt aattgtaaca
     9061 aaaggtatat tattctcaaa attaacctgc catataaaat aaatatgatg tttattaatt
     9121 gccacttacg aaatatgttg taattcgttt acattgtata gttgtgagag agctcccaat
     9181 aattatgtaa aatgataatt agaaaggatg ttgccattat gactgaaaac cgtatccgtg
     9241 agctgcgcaa gagccacaac atgtcacagg aagccctcgg ggctgtaata aacaccaccc
     9301 agcaggcggt aagcaagatg gaaaaagaca tctgtttcat ctccacagac ctgcttatca
     9361 gcatggcaga gtattttaat gttaccactg actatattct cggattatcc gatataaaac
     9421 gggatttaag cggacaattc cgtatgaatc aggaaatgga ccaatgttat gatattgtgc
     9481 ttcgctaccg taatctgtcg gacataaacc aaaaaacgct gagatgtgtt ttaaaacgtt
     9541 tagagcaggc acaattagag gaaattgagc tgtgtacaaa ggaagtgaaa acaaatgctg
     9601 aggatagctg tatgtgatga tgatttgaaa tttactgggg attttgagac acttgttctt
     9661 caggaaagcc gaaatatggg aatccgggta gaaacggatg tcttttccga tggtgataca
     9721 cttgtgaaaa gtattttgtc cggagaacgc tataacctta tttttctgga tattgaaatg
     9781 aagcaggtag atggtatttc agcagcccga tgtattcggg agattgaccg ttcagtatta
     9841 ctgatatata tatccggata cgatcaatat ctaaaagaac tgtttgaggt agaaccattt
     9901 cgtttccttt caaaaccagt aaacgataat aaattttgcc gttattttcg ggaagcctgt
     9961 cagcgaatcg gagaaacaga agtcttttat cagtttacat ttaataaaga aattaaaaaa
    10021 gttcctttaa aggatatcgt atattttgaa agccgtaatc gtatggtata tatttatttc
    10081 cgtgataata gttttgaaca tttttacgga aaactgaatg atgtggaaaa ggaactgaca
    10141 aacagtagac agtattttct gcgtacacat caatcttttt tagtgaatta tgattacata
    10201 aaaaaaatga atttctttaa tgtaacagtc agtattgggg gcaaagagat agaattgaaa
    10261 atcagcgaag accgacagaa agaagtaaga agacagcttt gcgagattgc gggtggaaag
    10321 gcggtcgttg agtaatggat tattttgtat ttgtatctaa tctgctttta ccgatactgc
    10381 agcttttaat tatacaaaaa tacatgaata ttttccttgg tccagggaac cagaaatatg
    10441 caggatgtat cggatgggtt gtctattatg tttttttagt tgcaataagt acgggaaggc
    10501 acttcccttc aatcctactt ttggcaggaa atattttatt agtattcata attagtacta
    10561 ttaccagaag aaaaagtctg aaaagccgtt tcatatttac tatcttgata tgta
//
