LOCUS       c00003_gnlPro..        13465 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JCPFCMPH_3.
ACCESSION   c00003_gnlPro..
VERSION     c00003_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 12:23:56
            Original ID  :: gnl|Prokka|JCPFCMPH_3
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 97379
            Orig. end    :: 110844
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13465
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[107379:110607]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13228
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..13465
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13465
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(979..2718)
                     /locus_tag="ctg3_84"
                     /transl_table=11
                     /translation="MALDGIFLRHIKSEIEKEALGARVSQIYQPNREELVFGLRTFSGN
                     KKLLLSARANSPRVNFCSSTPENPAQPPMFCMLLRKRIGGGKLVGLRQNGCDRVLMLDF
                     ECVNELGDTVMITVVCEIMGMYSNIIIVDSNGVIIDSLKRVDLTMSSKRLVLPNIKYEL
                     PESQNKLNLLECTALDVCTAVKNLDTEMPLNKALLRTIEGVSPIVCREIEYKVMEGATN
                     RIEGVLFDRLAVEIEKLKSVCSDCSGKPVVVYREDGKPMDFCFMNVEQYGDFAKVESKE
                     SFSDLLDGFYEARDSRDRMRVKSQSLTKLLNNTLERLARKIAKQKSELERCADREHLRI
                     CGDLLQANIYRIERGAEYADVENFYDENNAILRIKLNPAISPSANAQKYYKDYRKAKNA
                     EIMLKEQLEKGREELDYINSVLDTVDRAENEKDLAQIREELTEQGYLKVQKGKKPRQTT
                     LPPLEFESSDGFKILVGRNNRQNDKLTLKTASKNDMWLHTKDIHGSHVIVVSDGKEISD
                     TAIYEAARLAAYHSKARNSSQVPVDCTLVRYVSKPNGSKPGMVIYVNNKTLYVKPSQTV
                     EKQ"
     CDS             complement(2733..3218)
                     /locus_tag="ctg3_85"
                     /transl_table=11
                     /translation="MIKINIICIGKIKEKYFTDAIAEYAKRLTAFCKFNIIELSEERIK
                     SNIPNRSQIDEVIFSEGKRIMQKISPSDYVVAMCIEGKSMSSEELSKLIDNASVSGKST
                     VDFIIGGSYGLDESVKKRADVRLSMSRMTFPHQMARMILSEQIYRAFEISSNGKYHK"
     CDS             complement(3240..4028)
                     /locus_tag="ctg3_86"
                     /transl_table=11
                     /translation="LARAVPLFSGSKGNSYYIGSASEGVLIDAGRSCKQIENAMLANGL
                     DMGSIGAVFITHEHTDHCSALRVLAKRYGFKVYSSLGTLNALRAGNKLDPNTDADVITD
                     EVVIGNMRVQRIDTPHDAAESCCYRVTAPDGKSALIATDMGVMLPDVRTAAEQSDFVVL
                     ESNHDINMLKNGFYPYPLKQRILSNRGHLSNEACAKELVNLVEKGTLRLMLGHLSEENN
                     TVPLAMSTSVDLLTSNGMKYKSDYSLDVAPSVSTTKAIIF"
     CDS             complement(4151..5443)
                     /locus_tag="ctg3_87"
                     /transl_table=11
                     /translation="LEKFVVTGGKPLSGEVTISGAKNAAVAIIPAVILCDEPCQIENIP
                     NISDVSLISRILQQMGANVRRINRSSLYIDPTKIRTCNAVTDLVRGMRASYYLLGALLG
                     KYGKAKVALPGGCNFGVRPIDQHLKGFEALGATTQLVDGAIIEAECDSLVGTHVYLDVV
                     SVGATMNIMLAASKAKGQTIIENAAREPHIVDLANFLNSMGADVRGAGTDVIKIRGVEY
                     LHGITYSIIPDQIEAGTYMCAAAATRGCITVKNITPKHLESISAKLREMGVKITEYDEA
                     LKVDASSAPLKRCNIKTMPHPGFPTDCQPQFAALLMSVPGTSIINENVWDNRYQYVSEL
                     IRMGAQISVEGRLAIIEGGVPLTAAPVKATDLRAGAAMIIAALEINGTTEISNIQFIER
                     GYEDVVEKFRALGADIKKVYFTGDNEQELGA"
     CDS             6126..6842
                     /locus_tag="ctg3_88"
                     /transl_table=11
                     /translation="MSETAKEPKKISKRSSEEKIEIIVAIFLGITALATAWASWIGSLH
                     GGNQATNYTKSNNLSSEGNSMWNEASQNLMQDMITWNDINEANLNYQYAESKNDKAEME
                     KYQYQIDQLMSDNCTEEFLEAINWAMDQKENVTPFMKDGYTESYFAEAQATIEESDKLL
                     EQGKKDNANGDAFGLVSVIYSVVLFMLGIVGTFKNLPNRRIVLGVAVAGFILATIYMFT
                     IPMPTGFNILSYFGMA"
     CDS             7046..7363
                     /locus_tag="ctg3_89"
                     /transl_table=11
                     /translation="MENKEKTTTPEMPDIDVLFELADLFKVFGDSTRLRIMYTISENEM
                     SVLNIAEALSMEQSTISHQLRVLRQNKLVRVRREGKQIYYSLDDDHVKRIIEMGLDHVL
                     E"
     CDS             7376..9700
                     /locus_tag="ctg3_90"
                     /transl_table=11
                     /translation="MRYKYQLDNLNCAHCAGKIEAKIAETNGFEDVSFNFATKLLNFKS
                     EKQNPVSEIQAICDSIEDGVTVVDKTPKTNLKKYTYTLDNLNCAHCAGKIEAKIAETDG
                     FEDVSLNFATKLLNFKSEKQNPVSEIQAICDSIEDGVTVVDKTPKNDITTKAEPEITKK
                     KINHDTIFLAISIVLAVVSEILHLTLDGVAAVHYVVLAACFVATLLSGYKVFIKGAKNI
                     LKLRIDETTLMSVAVIAAFCLGDFVEAAMVTILFSIGEIFEDRAVDASRRDIEKLANIR
                     PDTATIIVDGAEQVVPAESVEIGSIIEVKPYERVPLDGIIIKGKTTLDTSALTGESLPV
                     DAGEGSEVLSGAINGSNLITVKTTKHFGDSTATRILQLVEDAAAQKGNSEKLISRFASV
                     YTPVVVLIAVAIAVIPPLCGLGAFSEWLYRALVCLVASCPCAIVISVPLSYYSGIGAAS
                     EIGVLIKGGKYIEALAKADTFVFDKTGTLTSGKLSVNKVNTVGSYSADEVLALAAASEK
                     YSAHPIASAIREKANGLELPELSDYSESAGHGTSAVYNGKTIQCGGSKILSDEQKKIAN
                     KDDSVFVIYDGQLIGSLNVSDTIRPEAKEVISQLKALGVKNTVMLTGDRQQPAENVKNE
                     LGLSECHAELLPAQKLELFKGLKSKCKGACFVGDGINDAPVLSASDCGIAMGFGSEAAI
                     EASDAVLASGTLKQLPKAIKIARSVINTVKGNIIFALSIKALVIILAAFGLAQIWMSVI
                     ADTGVSVVCVLIAARLLKKKY"
     CDS             10001..11623
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg3_91"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2e-42, bitscore:
                     137.1, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISGAEIMVKCLEAEGVDIVFGYPGAAICPFYDKVYDSSITHILV
                     RQEQNAAHAASGYARCSNRPGVCVATSGPGATNLITGIATAYTDSIPIVAITGQVRSDL
                     LGRDVFQEADITGACEPFVKHSYLVSKTEDLPRVFKEAFHIASTGRPGPVLIDIPVDIQ
                     ENEIESFEYPESVNIIGYKPNTKGHAIQVKKAVEAINASKRPVIVSGGGVLSSGIKLKL
                     QKFAETTGIPVISTMMGIGVMPSEHELYLGMLGTHGKAVANRALHEADLVIVCGARLGD
                     RAVAAPDQMSENTKVIHIDIDPAEIGKNVKTEIPIVGDMKNVINMLLDSIGDYKVTTMW
                     SETVKNWKKDLYREPPVFDGFVEPRTLVGHLSAMFRSKAILVADVGQNQIWCANNFRIR
                     EGRFLTTGGMGTMGYSIPAAIGAKFARPDRDVIVICGDGSFQMGLNELATIAGNQLGIK
                     IIIMKNARLGMVRELQDKHYGGRHSATILNGDPDFLKIADAYGIDHAEAHSNKEAENII
                     KGIVDSEKPFILVCDVHPDTPSI"
     CDS             11636..12127
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg3_92"
                     /sec_met_domain="ALS_ss_C (E-value: 1.3e-29, bitscore:
                     94.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQYTLSILVENQAGVLSKISGLFSRRGFNIDSLAVGVTQEPSVSR
                     ITIVANGDEYIVEQLEKQLNKLIPVIKVKRLNEGEFISRELVLIKVHCAASKRAEIVKT
                     VEIMQAKIVDVSPSSVTVEYCECASRINTLVDLLKPYGIREIVRTGTVAIDRGTASVSV
                     "
     CDS             12188..13228
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg3_93"
                     /sec_met_domain="IlvN (E-value: 5.7e-83, bitscore: 269.0,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 4e-60, bitscore: 194.9,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDYTKNMTAPIYYQSDCNLDLLKGKKIAIIGYGSQGHAHALNLK
                     DSGCDVIIGLYKGSKSWAKAEAQGFKVYTSAEAAKQADIIMILINDEKQAALYKNDIEP
                     NLEAGNMLMFAHGFNIHFGCIKPPKDVDVTMVAPKGPGHTVRSEYQVGKGVPCLVAVEQ
                     DATGQAKDLALAYALGIGGARAGVLETTFRTETETDLFGEQAVLCGGVCALMQAGFETL
                     CDAGYDPRNAYFECIHEMKLIVDLIYQSGFAGMRYSISNTAEYGDYITGPKIITEDTKK
                     AMRKVLSDIQDGTFAKDFLLDMSDAGSQVHFKAMRKIAAEAPAEVFGKEVRKLYSWSDE
                     DKLINN"
ORIGIN
        1 ttcaaacgag gacagcggaa gaacaatcac tcccgaaaga cttgcggagt gctataagga
       61 actcgaggac aaaggggtgc ataacatcaa ccttgtaacg gctgaccatt ttgcacacgc
      121 tgttgttaaa agtcttgaaa tttacaaacc gagaattccg attgtatata actgcagcgg
      181 atacacaagt ccgaaaactc tcagtatgct tgacggactt gttgacattt atcttcccga
      241 ctttaaatat gcagatgatt ttcttgcggt aaaatactct tccgcaccga attatgtcaa
      301 cacggctgtt gccgcaattc acgaaatgac ttttcaggtt ggtctgcctc agtttgacga
      361 tgacggcatt atgaaaaagg gcgttatcgt aaggcatctg attttgcctg cccacacaaa
      421 gaacagtctt gaagtgcttg atattgtaaa acgcagattc ggcgatcagg ttttgttaag
      481 tcttatgtgt cagtacattc ctatgggcaa ggtcagcgac agagagtttt cacgaattaa
      541 ccgtaaaatc acacgcagag aatatgacaa ggtaaagctt gaaatgatgc gactgggaat
      601 tgacggcttt acacaggagc tttcttccgc agatgaaagc tatgtccccg aatgggattt
      661 tgaaggataa ttttgtcagt ttggtcatct gaattcctct tcatttttca attggtattg
      721 tttacttggt attattctct tagtcttttt ctatgggtat tattaggctt caaattctga
      781 agtagtcccc ttcaaaatct gaaggggacg ggttcaaatt ctgaaggggg caggtgcaaa
      841 ttttgaaggg tatgagttca aattctgcac ccctaaaata cgaattttta cattcgattt
      901 taccgcccgt taaaaacaat taaattaaca taaaaacgga gagcgtcttg ccctccgttt
      961 aatttttatt aaaatatttt actgcttttc aaccgtttgt gacggtttta catacagggt
     1021 tttgttgttg acataaatca ccatacccgg ttttgagccg tttggctttg acacatagcg
     1081 aacaagtgtg cagtcaacgg gaacctgact gctgtttctc gccttactgt gatatgccgc
     1141 aagccgtgcc gcctcgtaga ttgccgtgtc ggaaatctct ttgccgtccg aaacaacaat
     1201 tacatgagaa ccgtgaatgt cctttgtgtg cagccacata tcgttctttg acgctgtttt
     1261 caaagtcagc ttatcattct ggcggttgtt tcttcctaca aggattttaa aaccgtcgct
     1321 tgattcaaat tcgagcggcg gcaaagttgt ctgacggggc tttttgccct tttgaacctt
     1381 tagatagccc tgttcggtaa gctcctctcg aatttgtgca aggtcttttt cattctccgc
     1441 acggtcaacc gtatcgagaa ccgagttaat ataatcaagc tcttccctgc ccttttcaag
     1501 ctgttctttg agcataattt cggcattttt agccttgcgg taatccttgt aatacttctg
     1561 agcatttgcc gaaggtgaga ttgccggatt aagctttatg cgtaaaattg cgttgttctc
     1621 atcgtaaaag ttttcaacat cagcatactc cgcaccacgc tcaatgcgat agatatttgc
     1681 ctgtaaaagg tcaccgcata tgcgaagatg ctcacggtct gcacagcgtt caagctcact
     1741 cttctgcttt gcaatttttc gtgcaagcct ttcaagtgtg ttgttcaaaa gctttgtaag
     1801 gctttgtgat ttcaccctca ttctgtcacg actgtcacga gcttcataga atccgtcaag
     1861 caaatcggag aagctttcct tactctcaac ctttgcaaaa tcgccgtact gctcaacatt
     1921 cataaagcag aagtccatag gcttgccgtc ctcacgataa accacaacag gcttgcccga
     1981 acaatcgctg caaacgcttt tcagcttttc aatttcaact gcgagtcggt caaaaagcac
     2041 accctcaatt ctgtttgttg cgccctccat aaccttgtat tcaatctcac ggcatacaat
     2101 cggagaaacg ccctcaattg tcctcaacag cgccttgtta agtggcattt ccgtgtcaag
     2161 attttttacg gctgtacaca catcaagtgc agtacattca agcagattca gcttgttctg
     2221 cgattcggga agttcgtatt ttatattcgg cagtacaagt cttttactgc tcattgtaag
     2281 atctacacgc ttgagtgaat cgatgatgac gccgtttgaa tcgacaataa ttatgttgct
     2341 gtacataccc ataatttcgc atacaacagt tatcatcaca gtatcgccaa gctcgttcac
     2401 gcactcgaaa tcgagcataa gaacacggtc gcaaccgttc tggcgaagtc ccacaagctt
     2461 tccgccgccg attctttttc gcaaaagcat acagaacatc ggaggttgtg caggattttc
     2521 gggtgttgac gaacagaagt tcactctcgg tgaatttgct cgtgcagaaa gcaacagctt
     2581 tttgttgccg gaaaatgttc tcaacccgaa cacaagctcc tctctgttcg gctgataaat
     2641 ctgcgacacc cttgcaccga gagcctcttt ttctatttca cttttaatat gtcttaaaaa
     2701 aattccgtca agcgccatag taactccgta aattatttgt gatatttacc gtttgatgaa
     2761 atctcaaacg cacggtaaat ctgttcgctt aaaatcattc ttgccatttg gtgaggaaag
     2821 gtcattctgc tcattgaaag acggacatcc gcccgttttt taaccgattc gtcaagtccg
     2881 tagctgccgc cgataataaa atcaacagtg ctttttccgc ttacggacgc attgtcaatc
     2941 agctttgaaa gctcctcact cgacatagac tttccctcaa tacacattgc aacaacataa
     3001 tccgaaggcg aaattttctg catgattcgt tttccctcag agaaaataac ctcatcaatc
     3061 tgcgacctat tcggtatgtt gctcttaatg cgttcttccg aaagctcaat aatattgaat
     3121 ttacaaaatg cggtcaagcg ttttgcatac tctgcaattg cgtcggtaaa atatttttct
     3181 ttgattttgc cgatacaaat tatgttaatc ttaatcatat ttctcttgtt tgtttaaggt
     3241 taaaagatga tggcttttgt tgtgcttaca ctcggggcaa catcaagcga ataatcgctt
     3301 ttgtacttca ttccgtttga tgtgagcagg tctacggatg ttgacattgc aagcggaacg
     3361 gtattatttt cttcgctgag atgaccgagc ataagtctta aagttccctt ttcaacaagg
     3421 ttaacaagtt cttttgcaca tgcctcattt gaaagatgcc ctctgtttga aaggattctc
     3481 tgctttagcg gataaggata aaatccgttt ttgagcatat tgatatcgtg atttgactca
     3541 agcacaacaa agtcgctctg ctctgcggca gttctgacat cgggcagcat aacacccata
     3601 tcggttgcta taagtgcgga ttttccgtcc ggagcagtaa cacggtaaca acagctttcc
     3661 gccgcatcgt ggggggtgtc aattcgctga acacgcatat tgccgattac aacctcgtca
     3721 gttataacat ctgcatccgt gtttggatca agcttattac ctgccctcaa agcattgagc
     3781 gtaccaaggc ttgaatacac cttaaagccg taacgctttg caagcacacg caacgcactg
     3841 caatggtcag tgtgttcgtg agttataaaa accgccccga tactgcccat atcaagtccg
     3901 tttgcaagca tggcattttc aatctgcttg catgaacggc ctgcgtcaat cagtacgcct
     3961 tcgcttgccg aacctatgta gtagctgtta cccttacttc cgctgaacag cggtactgct
     4021 cttgccaaaa caatcaatcc ttatctttag tataacgaat atgataacac aaattttaaa
     4081 atttgtaaat tatctcacaa aaaagccgtt ctcacaaaga aaacggcttt gatttctaat
     4141 taaattttag tcaggcaccg agttcctgct cgttgtctcc tgtaaaatac acctttttga
     4201 tatctgcacc gagtgctctg aacttttcaa caacatcttc atatccacgc tcaatgaact
     4261 gaatatttga aatctccgtt gtaccgttaa tttcaagagc ggcaataatc atagccgcac
     4321 ctgcacgaag gtcggttgcc ttaacaggag ccgctgtgag cggaacaccg ccctcaatga
     4381 ttgcaagtct accctcaaca gaaatctgcg cacccattct gataagctcg ctgacatact
     4441 gatagcgatt atcccaaaca ttctcgttga tgatgcttgt tccgggaacg ctcataagca
     4501 atgcggcaaa ctgcggctga cagtctgtcg gaaagccggg atgcggcatt gtcttgatgt
     4561 tacagcgctt tagcggagca gatgacgcat caaccttgag agcctcatca tattccgtaa
     4621 tcttaacacc catctcacgc agctttgcgc tgattgattc aagatgcttc ggtgtaatat
     4681 tctttaccgt aatacaacct cttgttgcgg cggcagcaca catatatgtt cctgcctcaa
     4741 tctggtcggg aataatcgaa taagtaatgc cgtgaagata ctcaacgcca cggattttga
     4801 taacatccgt acctgcaccc ctgacatccg cacccattga attaaggaag ttcgcaaggt
     4861 caacaatatg cggctctctt gcggcatttt cgataatggt ctgtcccttt gcctttgatg
     4921 cggcaagcat aatgttcatt gttgcaccaa cggacacaac atcaaggtac acatgtgtac
     4981 cgacaaggct gtcgcattct gcctctataa tcgcaccgtc aacaagctga gttgtcgcac
     5041 cgagagcctc aaagccttta agatgctggt caatcggacg cacgccaaag ttacagccgc
     5101 ccggaagagc caccttagcc ttgccgtact tgcccaaaag tgcgccgagg agataatatg
     5161 atgctctcat acctcttaca aggtcggtca cagcattgca tgtgcggatt tttgtaggat
     5221 caatatataa ggacgaacgg ttgattcgtc ttacattagc acccatctgc tgaagaattc
     5281 tgctgataag tgatacatcg ctgatgttag gaatattttc aatctggcat ggctcatcac
     5341 aaagaataac tgccggaata attgcaacgg ctgcattttt cgcaccgctg attgtcactt
     5401 cacccgataa tggctttccg ccggtaacta cgaacttctc caattgttac accccaatta
     5461 atgtgtagaa gatactttta actaaataag ctaaatatcc gaaaatgtat atctatatag
     5521 tgtataagta aaaatcaaaa attatacgaa tctaaaattc ataatgagaa ctaatttgtt
     5581 acattttatt aaaaacgaaa ccactcggtt acgcagatgt aatttaacaa ttctcttaca
     5641 gaaaatgata ctacaaaatt gtagtaaagt caacggaata ataaaactgt aatctatttt
     5701 tgggcaagtt gtactcaaat tattaatttg ttgctttttt tgtttttaat ataaccaacc
     5761 atgcttttta aaaccgtttt ttcctaaaaa gaagtaatta attaaagcaa ttttttgtaa
     5821 aataattaca aattgaaaca gttattatat tttcctaatt gaaaatttgc aggcaaatct
     5881 atcgtatata tttattcttt gcaaatcaaa cgaataaaac aaaaatatct aaaggtaaat
     5941 ttttttaaaa atcacagaca aaatgattat tatgccgaaa aaaagacttt actgccactt
     6001 gcattgaatt taaaactttt atcaattatg attgaaacag aatcagtcgg caagtgtcct
     6061 tttacaatat aataacgaca aaattaaggc attgcggcaa atttttaatt aacgggggat
     6121 tcagaatgag cgaaacagca aaagaaccga aaaaaataag taaaagaagc agtgaagaaa
     6181 aaattgaaat tattgttgcg atttttctcg gaataaccgc actcgccaca gcatgggcat
     6241 cgtggatagg ttcacttcac ggcggaaatc aggcgactaa ctacacaaaa agcaacaacc
     6301 tctcatcaga gggcaactcg atgtggaatg aggcttctca aaatcttatg caggatatga
     6361 tcacatggaa tgacatcaat gaggcaaacc ttaattacca atatgcggaa tctaaaaacg
     6421 ataaagcgga aatggaaaaa tatcagtacc aaattgatca gcttatgagt gataactgta
     6481 cagaagaatt tcttgaggca attaattggg caatggatca aaaggaaaat gtaactccgt
     6541 ttatgaagga cggttacacc gaaagttatt ttgcagaggc acaagctaca attgaagagt
     6601 cggacaaact tcttgaacaa ggtaagaaag ataacgcaaa cggtgacgca ttcggtcttg
     6661 taagcgtaat ttactcggtt gtactcttta tgctcggtat cgtaggcaca ttcaagaatc
     6721 ttccgaacag aagaattgtg ctcggtgttg cagttgcagg ttttattctt gccactatat
     6781 atatgtttac aattccgatg ccgacaggat tcaatattct cagttatttc ggaatggcat
     6841 aaaacaaaat attctgtact cacagcggtg aaagcaaatg cttttgccgc tgtttttttg
     6901 taaaaaatca aaaaaacatt acattttttc gtgtgtgtct attgactttt taaaaaggga
     6961 atgctatatt ataattaaca tatgagcata tcttcatatg ttcaagcata actattaacc
     7021 tgagagaaat ttaaagagga cgcctatgga aaacaaagaa aaaacaacca ctcccgaaat
     7081 gcccgacatt gatgtgctgt ttgagcttgc agaccttttt aaggttttcg gtgattcaac
     7141 ccgacttcgc attatgtaca ccatttcgga aaatgaaatg tcggtgctca acattgctga
     7201 agctctcagc atggagcaaa gcacaatttc ccaccaactg cgtgtgttaa ggcagaacaa
     7261 gctggtgcgt gttcgccgtg aaggaaagca gatttattac agccttgacg atgaccatgt
     7321 gaaacgaatc atagaaatgg gacttgacca tgttcttgaa taaggaggga gacatatgag
     7381 gtacaaatat cagcttgaca atctcaactg cgctcattgt gcaggcaaga ttgaggctaa
     7441 aattgcagaa acaaacggct ttgaggatgt gagcttcaat tttgcgacaa aacttctcaa
     7501 tttcaaaagt gaaaagcaga atcctgtttc cgaaattcag gcaatttgcg acagcattga
     7561 ggacggtgta accgttgttg acaaaactcc gaaaaccaat ctcaaaaaat acacctacac
     7621 tttagacaat ctcaattgtg ctcattgtgc gggcaaaatt gaggctaaaa ttgcagaaac
     7681 agacggcttt gaggatgtaa gccttaattt tgcgacaaaa cttctcaact tcaaaagcga
     7741 aaagcagaat cctgtttccg aaattcaggc aatttgcgac agcattgagg acggtgtaac
     7801 cgttgttgac aaaactccga aaaatgatat cacaacaaag gcagaacccg aaatcacgaa
     7861 aaagaaaatc aaccatgaca caatcttcct tgcaatttca attgtacttg ctgtagtgtc
     7921 cgaaattctc caccttacac ttgacggtgt tgcggctgtt cattatgttg tactcgcagc
     7981 gtgttttgtt gcaacacttc tttcgggtta caaggtattt atcaagggtg caaaaaacat
     8041 tctaaagctg agaattgacg aaacaacgct tatgtctgtt gcggtaattg cggcattctg
     8101 tcttggagat tttgttgagg cggcaatggt aacaatcctc ttttctatcg gtgaaatttt
     8161 tgaggatcga gcagttgacg catcccgccg tgacattgaa aagcttgcaa acattcgtcc
     8221 cgatacagca acaattattg ttgacggtgc ggaacaggtt gttcctgccg aaagcgttga
     8281 aatcggaagt atcattgaag tcaagccata cgaaagagtt ccgcttgacg gcattattat
     8341 taaaggtaaa acgactctcg acacatcggc tctcacaggc gaaagccttc ctgttgatgc
     8401 aggcgagggc agtgaggtac tcagcggcgc aatcaacggc agtaacctta ttactgtcaa
     8461 aaccacaaaa catttcggcg acagtaccgc aacaagaatt cttcagcttg ttgaagatgc
     8521 cgccgctcaa aagggcaaca gcgaaaagct tatttcaaga tttgcctctg tttacacacc
     8581 tgttgttgta ctcattgcgg ttgcaatcgc agtaattcct ccgctttgcg gactcggagc
     8641 attcagcgaa tggctctacc gtgcgcttgt ttgtcttgta gcgtcatgtc cgtgtgctat
     8701 tgttatttcc gtacctctct cctactattc gggtatcggt gcggcatccg aaatcggtgt
     8761 actcatcaag ggcggaaaat atattgaggc tcttgcaaaa gcagacacat tcgtattcga
     8821 taaaacaggc acgctcacaa gcggcaagct cagcgtaaac aaggttaata ctgtcggttc
     8881 atacagtgct gacgaagttc ttgctcttgc cgctgcaagc gaaaaatatt ctgctcatcc
     8941 gattgcctcc gcaatcagag aaaaggcaaa cggtcttgaa cttcccgagc tttccgacta
     9001 cagcgaaagt gccggtcacg gaacaagtgc agtttataac ggcaaaacta ttcagtgcgg
     9061 cggttcaaag attctttcgg acgaacagaa gaagattgca aataaagacg attctgtttt
     9121 cgtaatttat gacggtcagc ttatcggttc gctcaatgtc agcgatacga taagacctga
     9181 ggcaaaagag gttatctcac agcttaaagc gctcggtgtc aagaacacgg taatgctcac
     9241 gggcgacaga caacagcctg ccgaaaatgt taaaaacgaa ctcggacttt ccgaatgtca
     9301 tgcagagctt ctccctgctc aaaagcttga acttttcaag ggcttgaaat caaaatgcaa
     9361 gggtgcttgc tttgtgggcg acggcatcaa tgatgcccct gttctttcgg caagcgactg
     9421 cggtatcgca atgggattcg gcagtgaagc cgctattgaa gcgtcagacg cagttctcgc
     9481 atcaggcaca ctcaaacagc ttccaaaggc aattaaaatt gcaagaagtg ttatcaacac
     9541 tgtcaagggc aacatcatct ttgccctctc aatcaaggct cttgtaatta tccttgccgc
     9601 attcggtctt gcacaaatct ggatgtccgt tatcgccgac acaggcgtaa gcgtagtctg
     9661 cgtcctcata gctgcaagac tcctcaaaaa gaaatattga ttttctcaac aatcattact
     9721 gttcccgagc aggtaaaact gttcgggaat tttcttgtta ttactcttat acagatgctt
     9781 ttttggtcag cattttgctt ttgttgttaa tcatttatta tatctttttc aggcgatgac
     9841 agaataattt aaaatcctgc aaaaaattta atttatgggc aatactgctc tttacttttt
     9901 aaggtattta ttgtataatt agcggtaaag taaaagggta tatttaatgt tacaaaacac
     9961 cttttgctca caataaaaag gataggaggg acaaaacata atgatcagcg gtgctgaaat
    10021 tatggtaaaa tgtttggaag ccgagggcgt tgacatagtc tttggttatc ccggtgcggc
    10081 tatttgccca ttttacgata aagtttacga ctcgagcatt acccacattc ttgttcgtca
    10141 ggaacagaac gctgctcatg cggcaagcgg ctatgcaaga tgcagtaatc gtcccggtgt
    10201 ttgcgtggca acttccggtc ccggtgcaac caacctcatc acaggcattg caaccgccta
    10261 tacggactct attccgattg ttgccattac aggtcaggtt cgttccgacc ttctcggcag
    10321 agatgtcttt caggaagctg acatcacggg agcttgtgaa ccgtttgtaa agcacagtta
    10381 tctcgtcagc aaaacagaag accttccgag agttttcaaa gaggctttcc atattgcctc
    10441 aaccggcaga cccggtcctg tacttatcga cattcccgtt gatattcagg aaaatgaaat
    10501 tgaaagtttt gaatatcccg aaagcgtaaa cattatcggt tacaagccga acactaaggg
    10561 acacgcaatt caggttaaaa aggctgttga ggccatcaac gcaagcaagc gtcctgttat
    10621 cgtatcaggc ggtggcgtgc tgagttcggg tatcaagctt aaacttcaaa aatttgcaga
    10681 aactacgggt atccccgtta tttcaactat gatgggcatc ggtgttatgc ccagcgagca
    10741 tgagctttat ctcggaatgc tcggcactca cggcaaggct gttgccaacc gtgctcttca
    10801 cgaagccgac cttgtaatcg tatgcggtgc aagactcggt gacagagctg ttgcggctcc
    10861 cgaccagatg agtgaaaaca caaaggtaat tcacattgac attgaccctg ctgaaatcgg
    10921 taaaaatgtt aaaacagaaa ttccgattgt aggcgatatg aaaaatgtca tcaatatgct
    10981 gcttgacagc atcggcgatt acaaggttac aacaatgtgg agcgaaaccg taaagaactg
    11041 gaaaaaagac ctttaccgtg aacctcccgt atttgacggc tttgttgagc cgagaacact
    11101 tgtcggtcat ctcagtgcaa tgttccgctc aaaggcaatt cttgttgccg atgtaggaca
    11161 aaatcaaatc tggtgtgcaa acaacttccg tattcgtgag ggcagattcc tcacaacagg
    11221 cggtatgggt acaatgggtt actcaattcc cgctgcaatc ggtgcaaagt ttgcaagacc
    11281 cgaccgtgat gttattgtaa tctgcggtga cggcagtttt cagatggggc ttaatgagct
    11341 tgcgactatt gcaggcaatc agctcggaat taaaatcatc attatgaaaa acgcacgact
    11401 cggaatggtt cgtgaacttc aggacaaaca ctacggcggc agacactccg caacaattct
    11461 caacggtgat cccgacttct tgaagattgc cgatgcttac ggcattgacc atgcagaggc
    11521 tcattcaaac aaggaagccg aaaacatcat caagggtatt gttgattcgg aaaaaccgtt
    11581 cattcttgtt tgcgatgttc accccgacac tccgtcaatt taatgaggtg ataaaatgca
    11641 gtatacatta tcaatacttg ttgaaaatca ggcgggcgtt ctttcaaaaa tttcgggact
    11701 tttctctcgc cgaggtttta acatcgactc acttgcagta ggtgttactc aggaaccgtc
    11761 ggtttcccga atcacaatcg ttgcaaacgg tgacgagtac attgttgaac agcttgaaaa
    11821 acagctcaac aagctcattc ccgttattaa ggtaaaaagg cttaacgagg gcgaatttat
    11881 cagccgtgag cttgtattaa tcaaggttca ctgcgccgcc tcaaaaagag ccgaaattgt
    11941 caaaacggtt gaaattatgc aggcgaaaat cgttgatgta tccccttcgt cagttaccgt
    12001 tgagtactgc gaatgtgcaa gccgcatcaa cacgcttgtt gacttactca agccttatgg
    12061 tatccgtgag attgtaagaa caggtactgt tgccattgac agaggcacag cttcggtttc
    12121 cgtttaatct tacagttagc atatatttta atttatatgc cgcgtttgcg gtaaggagga
    12181 ctttaatatg aaagactaca caaaaaacat gacagcacca atctactatc agtcagattg
    12241 taaccttgac cttctcaagg gtaagaaaat tgctattatc ggttacggca gccagggtca
    12301 tgcacacgct ctcaacctca aggattcagg ttgcgatgta atcatcggtc tttacaaagg
    12361 cagcaagagc tgggcaaagg ctgaggcaca gggctttaag gtatatacat cggcagaggc
    12421 tgcaaagcag gctgacatca tcatgattct tatcaacgat gaaaagcagg cagctcttta
    12481 caagaacgac atcgagccaa acctcgaagc aggcaatatg cttatgttcg ctcacggctt
    12541 taacattcac ttcggttgca tcaagcctcc aaaggatgtt gatgttacaa tggtagctcc
    12601 taagggacct ggtcacacag ttcgttcaga gtatcaggtt ggtaagggtg taccttgcct
    12661 cgttgctgtt gagcaggatg ctacaggtca ggctaaggat ctcgcacttg catatgcact
    12721 cggtatcggc ggtgcaagag ccggcgttct tgaaacaaca ttcagaacag aaacagaaac
    12781 agacctcttc ggtgaacagg ctgttctttg cggcggtgtt tgcgcactta tgcaggcagg
    12841 ttttgaaaca ctttgcgatg ccggttacga cccaagaaac gcttactttg agtgtattca
    12901 tgagatgaag ctcatcgttg accttatcta tcagtcaggt tttgcaggca tgagatattc
    12961 aatctctaac acagctgagt acggtgacta catcacaggt ccaaagatca tcacagagga
    13021 tactaagaag gctatgagaa aggttctttc tgacattcag gacggtacat ttgctaagga
    13081 cttcctcctt gacatgagcg atgccggttc acaggttcac ttcaaggcta tgagaaagat
    13141 cgctgccgaa gctcctgccg aagtattcgg taaggaagtt agaaagctct acagctggtc
    13201 tgacgaagat aagctcatca acaactaatg ttttttagtt cgtgaagtta gtttgatata
    13261 ttcaaatttc tgtcacccga gcattacata gtacgaattt agggtagctt gattttcaag
    13321 ctaccctttt tgcgagtacc tcgctcttag ttcgtgtagg tagtttgtga taatttacaa
    13381 ctacttattc ccgagcttaa catagttata attttcggct ctatgtcaat agttggggta
    13441 gcattaaaac agaataattg aaatt
//
