LOCUS       c00011_gnlPro..        13339 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CGNAIPGD_11.
ACCESSION   c00011_gnlPro..
VERSION     c00011_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 17:43:09
            Original ID  :: gnl|Prokka|CGNAIPGD_11
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13339
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13339
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[296:6377]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      297..6377
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..13339
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13339
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             297..2099
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg11_1"
                     /sec_met_domain="ILVD_EDD (E-value: 2.5e-219, bitscore:
                     718.5, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKHQLRSSFSTQGRRMAGARALWTANGMKKEQMGKPIIAIVNSFT
                     QFVPGHVHLHEIGQFVKEEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNGQHLDLID
                     AMIKSADESVGDKEVAQIEQHACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATH
                     ENRKKLFEDAARLIVENAFRYYEEGDESVLPRSIATREAFLNAMTLDIAMGGSTNTVLH
                     LLAVAHEAGADFKMDDIDMLSRKTPCLCKVAPNTQKYHVQDVNRAGGIIAIMDELAKGG
                     LVDTNVHRVDGMTLAEAIDRYSITSSNVCKEAIKKYSSAAAGKFNLVLGSQNASYKELD
                     TDRATGCIRDLEHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFTGPAKVFDSQDA
                     ACDGILGGKVVSGDVVVITHEGPKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGG
                     TSGLSIGHVSPEAAAGGNIGKIKDGDIIEIDIPNRSINVKLTDEELAARPMTPVTRNRE
                     VSKALKAYASMVSSADKGAVRLID"
     CDS             2191..3942
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg11_2"
                     /sec_met_domain="TPP_enzyme_C (E-value: 8.5e-48, bitscore:
                     151.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADNNKKSNFSSLSQGEGRGEALITGAEALMRSLEHQGVKTIFGY
                     PGGSIMPVFDALYDHRKELNHILVRHEQGATHAAQGFARVSGEVGVCLVTSGPGATNTI
                     TGIADAMIDSTPIVVIAGQVGTNFLGTDAFQEVDLVGITQPITKWSYQIRRAEDVAWAV
                     ARAFYVAKSGRPGPVVLDFAKNAQVEKTEYAPTKVDYVRSYLPVPEMEPEAIRQAAELI
                     NGAERPLVLVGQGVELGEAQQELRAFIEKAGMPAGCTLLGLSALPTDHPLNKGMLGMHG
                     NLGPNINTNKCDVLIAVGMRFDDRVTGKLETYAKQAKIIHFDIDPAEIDKNVKTDVAVL
                     GDCKETLAAVTQLLEPANHQEWIDSFRQYEEVEEEKVIRPELHPAGKALSMGEVVRAVS
                     EATHNEAILVTDVGQNQMMSARYFKYSKERSIVTSGGLGTMGFGLPAAIGATFGRPDRT
                     VCVFMGDGGLQMNLQELGTIMEQKAPVKMILLNNNFLGNVRQWQAMFFNRRYSFTPMMN
                     PDYMKIASAYDIPARRVMTREELAKAIDEMIATDGPFLLEACVEEEGNVMPMTPPGGSV
                     NQMLLEC"
     CDS             3975..4535
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg11_3"
                     /sec_met_domain="ALS_ss_C (E-value: 6.1e-20, bitscore:
                     60.8, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKKLYTIIVHSENFAGLLNQVTAVFTRRQINIESLNVSASSIKG
                     VHKYTITAWTDKDTIEKVTKQITKKIDVLQAHYFTDDEIYQHEIALYKITTPTLEEKPE
                     VSKVIRKYNARIVEVNAVFAIVEKNGMSEEITNLYEELRQLDCVLQFVRSGRVAITTSC
                     FERVNEYLADREAKYRQSKHQES"
     CDS             4532..4987
                     /locus_tag="ctg11_4"
                     /transl_table=11
                     /translation="MMSENNKIGTYKFVAEPFHVDFTGRLTMGVLGNHLLNCAGFHASD
                     RGFGIATLNEDNYTWVLSRLAVELDEMPYQYEDFSIQTWVENVYRLFTDRNFAIIDKEG
                     KKIGYARSVWAMISMNTRKPADLLALHSGSIVDYVCDEPCPIEKPRG"
     CDS             4990..5283
                     /locus_tag="ctg11_5"
                     /transl_table=11
                     /translation="VASKEPVAALVAKYSDIDINGHVNSIRYIEHILDLFPIEMYKEKR
                     IRRFEMAYVAESYYGDELTLFMDDAGEGVYDVEVKKNGSEVVCRSKVIFTEK"
     CDS             5334..6377
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg11_6"
                     /sec_met_domain="IlvN (E-value: 1.9e-47, bitscore: 150.3,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 3.5e-41, bitscore: 130.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGVIENVMTREEFPLEKAREILKDETIAVIGYGVQGPGQ
                     ACNLRDNGFNVIVGQRPGKTYEKAVADGWVPGETLFGIEEACQKGTIVMCLLSDAAVMS
                     VWPTIKPYLTSGKALYFSHGFAITWNDRTGVVPPKDIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAVYQDATGKAFDKTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMT
                     PFHDAIKPVVQKLYASVKSGNEAQISIDSNSKPDYREKLNAELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(6439..8352)
                     /locus_tag="ctg11_7"
                     /transl_table=11
                     /translation="MITFATMKEQDSNSPIIHLQQQQLLLRMEYEYEKEEFKRQTENMG
                     IARKVKRGLCWYPATPGRSYYNSLNQLVIEITHTENTDIEHNFEFGRPVCFFRQSADGK
                     ITYMNFTATVSYADETRMVAIMPGAGAVMEVQETDNLGVQLYFDETSYRTMFEALEDTL
                     RSKGNRLAELRDILLGTSKAGFRELYPVRFPWLNSTQETAVNKVLCARDVAIVHGPPGT
                     GKTTTLVEAIYETLHREPQVLVCAQSNTAVDWISEKLVDRGVNVLRIGNPTRVNDKMLS
                     FTYERRFENHPLYPELWSIRKNLRELGSRARRGSYDEREGVRSRMSRLRDRATALEIQI
                     NAELFDGAHVIASTLVSSNHRLLNGRRFGTLFIDEAAQALEAACWIAIRKADRVVLAGD
                     HCQLPPTIKCHEAARGGLERTLMEKVVSNKPAVVSLLKVQYRMHEEIMKFPSQWFYNGE
                     LEAASEVRYRGILDWDTPIHWIDTSEMDFKEEFVGETFGRINKAEADLLLSELKIYINR
                     IGGSRILEEKIDFGIISPYKAQVQYLRNKIKADASLKPYRSLFTVNTVDGFQGQERDVI
                     FISLVRANEEGQIGFLNDLRRMNVAITRARMKLVILGEAETLKHHGFYRKLLEFIQNIG
                     NQ"
     CDS             8467..10710
                     /locus_tag="ctg11_8"
                     /transl_table=11
                     /translation="MVYDLTMLKTFYAAYSEKIERVRNVLRRPMTLAEKILYAHLYDGD
                     KVKNYRRGEDYVNFRPDRVAMQDATAQMALLQFMNAGREQVAVPSTVHCDHLIQAYKGA
                     KEDVATATKTNEEVYNFLRDVSSRYGIGFWQPGAGIIHQVVLENYAFPGGMMVGTDSHT
                     PNAGGLGMVAIGVGGADAVDVMTGMEWELKMPRLIGVHLKGKLSGWVAPKDVILKLAGI
                     LTVKGGTNAIIEYFGPGTASLSATGKATICNMGAEVGATTSLFPYDERMGTYLKATGRE
                     EVAKMAASVAVDLRADDEVLANPEKYYDRIIEIDLSLLEPYINGPFTPDAATPISKFAE
                     VVITNNYPRRMEVGLIGSCTNSSYQDLSRAASLARQVKEKNLKVASPLIVNPGSEQIRA
                     TAERDGMIAAFEDIGATIMANACGPCIGQWKRHTDDPERKNSIVTSFNRNFAKRADGNP
                     NTFAYVASPEITMALTIAGDLCFDPLRDTLVNAKGEVVKLSEPVGEELPAHGFIGGQKG
                     YIAPNKGQTEITVNPHSQRLQLLTPFPAWDGMDLLNMPLLIKVQGKCTTDHISMAGPWL
                     RFRGHLENISDNMLMGAVNAFNGETNKVWNRSTNTYGTVSGTAKLYKSEGIPSIVVAEE
                     NYGEGSSREHAAMEPRFLNVRAILAKSFARIHETNLKKQGMLALTFTDKADYDKIRERD
                     LISVMGLKDFASGRTLKVVLHHEDGSKESFEVQHTYNEQQIAWFRAGSALNAR"
     CDS             10714..11874
                     /locus_tag="ctg11_9"
                     /transl_table=11
                     /translation="MEKITVPFITGDGVGAEVTPSMQAVVNAAVKKSYGDRRGIEWKEV
                     LAGERAFHETGSWLPDETMEAFRTYKVGIKGPLTTPVGGGIRSLNVALRQTLDLYVCQR
                     PVRWYKGIVSPLKEPQKVDMCVFRENTEDIYAGIEWEAGTPEAEKFYRFLRDDMGVTKV
                     RFPETSSFGVKPVSREGTERLVRAACQYALEHHLPSVTLVHKGNIMKFTEGGFKKWGYE
                     LAEREFGKELAEGRLVIKDCIADAFLQNTLLIPEEYSVIATLNLNGDYVSDQLAAMVGG
                     IGIAPGANINYKTGHAIFEATHGTAPNIAGKDIVNPCSIILSAVMMLEYLGWKEAASLI
                     ENALEQSFTEARATADLARFMPGGVSLSTSAFTREIVRRIENGNNE"
     CDS             11887..13230
                     /locus_tag="ctg11_10"
                     /transl_table=11
                     /translation="MKKEYLIYKLSEDLKEATRIENELFRKFDVKRGLRNEDGTGVLVG
                     LTKIGNVVGYERIPGGGLKPIPGKLFYRGYDVDDLAHAIIKEKRFGFEEIAYLLLSGRL
                     PDKEELSSFRELINDNMPLEQKTKMNIIELEGNNIMNILARSVLEMYRFDPDADDTSRD
                     NLMRQSIELISKFPTIIAYAYNMLRHATHGRSLHIRHPQENLSIAENFLYMLKKDYTEL
                     DARTLDLLLVLQAEHGGGNNSTFTVRVTSSTGTDTYSSIAAGIGSLKGPLHGGANIQVA
                     DMFHHLQENIQDWTNVDEIDTYFTRMLNKEAYNKTGLIYGIGHAVYTISDPRAILLKEL
                     ARDLAREKGKEREFAFLELLEERAIDVFGRVKNNGKTVSSNVDFYSGFVYEMIGLPQEI
                     FTPLFAMARIVGWCAHRNEELNFEGKRIIRPAYKNVLDEVAYVPIKKR"
ORIGIN
        1 ggattttagg gcgatatttt cttacgatta tcatatttat cttatttttt tcttcaattt
       61 gtttggagat tataaaaaag cccttacctt tgcagcacgt ttgaaacaaa aaagaagaat
      121 taagttatga atttacatac atctattaac ctggcagtcc tgcatattat tcgcgtcgtg
      181 gtggtggcat caagagcgtg agaaaggtta tgtatgtatt cgtacgttag aagataattt
      241 attaagcctt tctcactata gtgggagagg ctttttcatt aaaaggagat ttgaaaatga
      301 agcatcagtt acgcagctcg ttcagcacac aaggtcgccg catggcggga gcccgtgcat
      361 tgtggacggc gaatggtatg aagaaggaac agatgggtaa gcccattatc gctatagtca
      421 attcatttac acaattcgtc cccgggcatg tacatctgca cgaaataggc cagtttgtaa
      481 aggaagagat tgaaaaactg gggtgttttg ctgcggagtt caatacgatt gccattgacg
      541 acggtatcgc tatgggacac gacggtatgc tttattccct gccttcaaga gatatcattg
      601 ccgatagtgt ggagtatatg gtaaatgccc ataaggcaga tgctatggtt tgcatcagta
      661 actgtgacaa gattactccg gggatgctga tggcggctat gaggctgaat ataccgactg
      721 tgtttgtttc aggcggtccg atggaagccg gggaatggaa cggacagcat ttggatttga
      781 ttgatgccat gattaaatct gctgatgaaa gtgtgggcga taaagaggtg gcacagattg
      841 agcaacatgc ctgccccact tgcggatgct gctcaggcat gtttaccgct aattccatga
      901 attgcttgaa tgaagcgatt ggattggcac tgcccggtaa cggcacgatt gtagccactc
      961 acgaaaatcg caagaaacta tttgaggatg cagccaggtt gattgtagag aatgccttta
     1021 gatattatga agaaggggat gagagtgtac tcccgcgcag tattgctacc cgcgaggcat
     1081 ttttgaatgc catgacgctg gatattgcga tgggcggttc cactaatacg gtacttcatt
     1141 tgttggctgt ggctcacgaa gccggagcgg attttaagat ggacgacatt gacatgctct
     1201 cccgcaagac cccctgctta tgcaaggtag ctcccaatac ccaaaagtat catgtacaag
     1261 acgttaaccg tgccggtggc atcattgcca tcatggatga gcttgccaag ggcggattgg
     1321 tcgatacgaa tgtccaccgt gtggatggaa tgacgttggc agaggcaatc gaccggtata
     1381 gtattaccag ctctaatgta tgtaaagagg caatcaagaa atactccagt gcggcagccg
     1441 gaaagttcaa tctggtactc ggctcacaaa atgcgtctta taaggaactc gatacggacc
     1501 gtgcgaccgg ttgtatccgt gatttggaac atgcatacag caaggatggc ggtctggcgg
     1561 ttttgaaggg aaatatagct caggacggtt gcgttgtcaa gactgcgggt gtagacgaga
     1621 gtatctggaa atttacgggg ccagcgaaag tcttcgactc acaagatgcg gcttgtgacg
     1681 gtattctggg tggaaaggtg gtcagtggag acgtcgtcgt catcactcac gaagggccga
     1741 aaggtggacc gggtatgcaa gagatgcttt atcctacttc ttatatcaaa tcccgccatc
     1801 tgggtaagga gtgtgcattg attaccgacg ggcgtttcag tggtggtact tccggactaa
     1861 gtatcggaca tgtttctccc gaagcggctg ccggtggtaa tatcggcaag attaaggatg
     1921 gggacattat cgaaattgat ataccgaacc gttctatcaa tgtgaagttg acggatgaag
     1981 agcttgcagc acgccctatg actccggtaa cccgcaaccg tgaagtctcc aaagcattga
     2041 aagcatatgc cagtatggtg agttccgctg acaaaggggc tgtgaggctg attgattaaa
     2101 agcccccctt tccgaaagcg aggggaggag agaatgaaac aaatttttca agctactatt
     2161 gagcttttaa atataatgaa tagataaagt atggctgata ataataaaaa gagtaacttt
     2221 tcctccctct cccaaggaga gggtcggggt gaggctctaa taacaggcgc agaagcattg
     2281 atgcgttctc tggagcatca gggagtaaag actattttcg gttatccggg agggagcatc
     2341 atgccggtat tcgatgcctt atacgaccac cggaaggaat tgaaccacat cttggttcgc
     2401 catgaacaag gagcaaccca tgcggcacaa ggctttgcac gtgtatcagg cgaggttggc
     2461 gtttgtctgg ttaccagtgg accgggtgct accaatacta tcacgggcat tgcagatgcc
     2521 atgattgaca gtacgcctat cgttgtcatt gccggccagg tagggacgaa cttcttgggt
     2581 acggatgcat ttcaggaagt ggacttggta ggcattactc agcctatcac gaaatggagt
     2641 taccagattc gtcgtgcaga agatgtggcc tgggcagtgg cacgtgcttt ctatgtggca
     2701 aagagcggac gtccgggacc ggtcgtgctg gattttgcta aaaacgccca agtggagaaa
     2761 acagaatatg cgcctactaa ggtggactat gtccgtagct atcttcccgt tcccgaaatg
     2821 gagccggagg ccatacggca ggctgctgaa ttaataaatg gtgcggaacg gcctttggtg
     2881 ctggtaggac aaggcgtgga gctgggagaa gcccagcaag agcttcgtgc tttcattgag
     2941 aaagccggaa tgcctgccgg atgcacttta ttgggacttt ctgccttgcc tacggaccat
     3001 ccgttgaaca aaggaatgct tggtatgcac ggtaacctgg ggcccaatat caataccaat
     3061 aaatgtgatg tccttatcgc cgtaggcatg cgctttgatg accgtgtgac gggtaaattg
     3121 gaaacatatg ccaagcaggc gaagattatc cactttgata ttgaccctgc cgaaatagat
     3181 aagaatgtaa agaccgatgt tgctgtcctg ggagattgca aagagacact ggctgccgtt
     3241 acccaattgc tggaacccgc caaccatcag gaatggattg acagtttccg gcaatacgag
     3301 gaagtggaag aggaaaaggt aatccgtccg gaattacatc cggcaggaaa agcgctaagc
     3361 atgggtgagg tggtgcgtgc tgtgagtgag gctacccata acgaggcgat attggtgact
     3421 gatgtcggcc agaatcagat gatgtccgcc cgttatttca aatacagcaa ggaacgtagc
     3481 attgttactt ccggtggcct gggtactatg ggcttcggcc ttccggcagc tatcggtgcc
     3541 acttttggac gtccggaccg cacggtatgc gtattcatgg gagacggcgg cttgcagatg
     3601 aacctgcagg aactgggtac catcatggaa caaaaggctc cggtgaagat gattctgttg
     3661 aacaataact tcttgggcaa tgttcgtcaa tggcaggcga tgtttttcaa tcgtcgttat
     3721 tcgtttactc cgatgatgaa tccggattat atgaagattg cttcggcata tgatattcct
     3781 gcacgcaggg taatgacccg cgaggagctg gcaaaagcga ttgacgagat gatagcaacc
     3841 gacggaccgt tcctgctcga agcttgtgtg gaggaagaag gaaatgtaat gccgatgaca
     3901 cctccgggcg gttcggtcaa tcagatgttg ttggaatgct gaagtcatgc gaaattaaag
     3961 aatttactct atctatggat aaaaaactat atacaatcat tgttcattcg gaaaactttg
     4021 ccggtttgct gaatcaagtg acggctgtgt ttacccgtcg gcagataaac atcgaaagtt
     4081 taaatgtatc ggcctcctcc atcaaggggg tacataaata taccattacc gcttggacgg
     4141 acaaggatac cattgaaaag gtgaccaagc agattaccaa gaaaatagat gtgctgcaag
     4201 cccattattt tacggatgat gaaatctatc agcacgagat tgctctctat aaaataacga
     4261 cccctacgct ggaagaaaaa ccggaggtgt ccaaagtaat ccgtaagtac aatgcccgta
     4321 ttgtggaggt gaatgctgta tttgccattg ttgagaagaa tggcatgagt gaggaaataa
     4381 ccaatcttta tgaggagttg cgccagttgg attgcgtact tcagttcgtc cgttcgggtc
     4441 gcgtagccat tacgaccagc tgctttgagc gtgtcaatga atatctggcg gaccgtgaag
     4501 caaaatatcg tcaaagtaaa caccaagaat catgatgagc gagaacaata agataggtac
     4561 ctacaagttt gttgccgaac cgtttcatgt cgactttacc ggacggctga caatgggagt
     4621 attgggcaac catttgttga attgtgcggg tttccatgcc agcgaccgcg gttttggcat
     4681 cgcgactcta aacgaggaca attatacttg ggtattgtcc cgtctggctg tcgaactgga
     4741 tgaaatgcct tatcagtacg aagatttctc cattcagact tgggtggaga atgtctatcg
     4801 cctttttaca gaccgtaatt tcgctatcat cgataaggag ggtaagaaga ttgggtatgc
     4861 acgttccgtt tgggcgatga ttagcatgaa tacccgtaag ccggcagatt tgctggctct
     4921 tcatagtggc agcattgtag attatgtttg cgatgagcct tgcccgatag aaaaacctcg
     4981 cggataaagg tggcctcaaa ggaaccggtt gctgctttgg tagccaaata cagtgatatt
     5041 gacattaacg ggcatgtgaa cagcatccgt tacatcgagc atatccttga tttgttcccg
     5101 atagagatgt ataaggagaa gcgcatccgt cgttttgaaa tggcatatgt agccgaaagc
     5161 tattatgggg atgagttgac tttgttcatg gatgatgccg gtgagggcgt ttacgatgtg
     5221 gaggtgaaaa agaatggcag cgaagtggtc tgtcgctcta aagtgatatt tacagagaaa
     5281 taaataaatt tatcaacgtt ggcgtaagcc acaaataaaa attaaaacaa aaaatggcac
     5341 aattgaattt tggcggtgtt attgagaatg taatgacccg cgaagaattt cctttggaaa
     5401 aagcacgtga gattttgaaa gatgaaacaa ttgcagtaat cggttatggc gtacaaggcc
     5461 cgggccaggc ttgcaacttg cgtgataacg gtttcaatgt gattgtagga caacgtccgg
     5521 gtaagacata cgaaaaggct gtggctgacg gatgggtacc gggtgagact ttgttcggca
     5581 tcgaagaggc ttgtcagaaa ggtactatcg tcatgtgtct gttgtctgac gcagctgtaa
     5641 tgtctgtatg gccgactatc aaaccttact tgacttccgg aaaggctctt tacttctctc
     5701 atggttttgc tattacctgg aacgaccgta ccggcgtggt tcctcctaaa gatattgatg
     5761 ttattatggt tgctcccaaa ggttccggta cttcacttcg taccatgttc ctcgaagggc
     5821 gtggcttgaa ctcatcatat gccgtctatc aagatgctac gggtaaggct tttgacaaga
     5881 cgattgcact gggtatcggt atcggttcgg gatatttgtt cgagacaact ttcatccgcg
     5941 aagccacttc cgacttgacc ggtgaacgcg gttcattgat gggtgctatc cagggattgc
     6001 tgttggctca gtatgaagta ttgcgcgaaa acggccatac tccttctgaa gcattcaatg
     6061 aaacagtgga agagttgact caatctttga tgccattgtt tgccaagaac ggtatggact
     6121 ggatgtatgc caactgttct actacggcac agcgtggtgc gctggattgg atgaccccgt
     6181 tccatgatgc catcaagccg gttgtacaga aattgtatgc aagtgtgaag tcgggcaacg
     6241 aagcccagat ttctatcgac agtaactcca aacccgatta tcgtgagaag ctgaatgcag
     6301 aattgaaagc cttgcgtgaa agcgaaatgt ggcagacagc tgttacagtt cgtaaacttc
     6361 gtccggaaaa caattaatca gctttatata aataggtgaa ataccctctt cggtgttacc
     6421 ggagggggta tttctttatt attgattccc tatattttga ataaactcca atagcttccg
     6481 gtaaaaaccg tgatgtttca gcgtctctgc ctctcccaat atcaccagct tcatacgtgc
     6541 ccgggtgatg gctacattca ttctccttaa atcattcagg aatcctatct gtccttcttc
     6601 gttggcacgg acaaggctga tgaagataac atcgcgctct tgcccttgga agccatccac
     6661 cgtatttaca gtgaacaagc tgcgataagg cttgagtgaa gcgtctgcct ttatcttgtt
     6721 gcggagatat tgcacttgtg ccttgtaagg ggagatgatg ccgaagtcta ttttttcttc
     6781 cagaatgcgg ctgccaccga tacggttgat gtagattttc agttctgata ggagcaggtc
     6841 cgcttccgcc ttattaatgc gtccgaaagt ctctcccaca aattcttctt tgaaatccat
     6901 ttcggaggtg tcaatccagt ggataggggt atcccagtcc aggatgcccc ggtaacgcac
     6961 ttcggaagcg gcttccaact cgccattata aaaccattgg gaaggaaatt tcatgatttc
     7021 ctcgtgcatg cggtattgca ctttcagcaa agagacaacg gcaggtttgt tggacaccac
     7081 tttctccatc aatgttcgtt ccagacctcc acgggcggct tcgtggcatt ttatggtggg
     7141 cggaagttgg cagtggtcac ccgccaatac cacgcggtct gcttttcgga tagctatcca
     7201 gcaggcagct tctaaggcct gggctgcttc atcaatgaaa agggtgccga aacggcgtcc
     7261 gttcagcagc cggtgattgc tgcttactag cgtggaggct atgacatgtg ccccatcaaa
     7321 aagctctgca ttgatttgta tttccaatgc ggtggcgcgg tcgcgcaggc ggctcatacg
     7381 gctgcgtact ccttcgcgtt cgtcatagct gccacggcgg gcacggctgc ccagttcacg
     7441 gagatttttc cggatgctcc acagctccgg ataaagcgga tggttctcga aacgacgctc
     7501 gtaggtaaag gaaagcatct tgtcgttgac acgggtcgga ttgccgatac gcaggacatt
     7561 gacgccacgg tccacaagtt tttccgaaat ccagtcgacg gcagtattgc tttgggcaca
     7621 taccagtacc tgcggttccc gatgcagggt ttcgtagatg gcttccacta aggtggtcgt
     7681 ttttccggtt cccggaggac catgtacaat ggccacgtcg cgggcacaca gcactttgtt
     7741 tacagctgtc tcctgcgtgg agttcagcca gggaaaccgt acggggtaga gctctcggaa
     7801 accggctttc gaggttccca gcaatatgtc ccgcaattcg gccaggcggt tgcctttgga
     7861 gcgtaacgta tcttccaagg cttcgaacat ggtccgatag gatgtttcgt cgaaataaag
     7921 ttgcacgccg aggttgtccg tttcctgcac ttccatcacg gcaccggctc cgggcattat
     7981 cgctaccatc cgtgtctcgt cggcatagct tacggtagcg gtgaagttca tataggttat
     8041 ttttccatcg gcagactggc ggaaaaaaca tacgggacgg ccgaactcaa aattatgttc
     8101 tatatcggta ttttctgtgt gtgtaatttc tattactaat tgattcagtg aattatagta
     8161 acttcgtccc ggagtggcag gataccagca aagtccccgt ttcactttcc gggcaatccc
     8221 catgttttcg gtttggcgtt tgaattcctc tttttcgtat tcgtattcca tgcgcagcaa
     8281 aagttgctgc tgttggaggt gaataatagg actatttgaa tcttgttcct tcatggttgc
     8341 aaaggtaatc attcttcgct tccgacggaa aaaatgcttt attttgttaa actattcagc
     8401 ctttttattt gtttatgata ttaatttgta atctttacaa taatgaaaaa ctaaaaaata
     8461 gtggttatgg tatatgattt aacgatgctc aaaacgtttt atgccgctta ttcggagaag
     8521 atagaacgcg tacggaacgt actgcggcgt ccgatgactt tagcggagaa aattttgtat
     8581 gctcatttgt atgatgggga taaagtgaag aactacagac ggggagaaga ctatgtgaat
     8641 ttccgtcccg accgtgtggc catgcaggat gcaacggctc aaatggcctt attgcaattt
     8701 atgaatgcag gccgtgagca ggttgccgtg ccttccactg tgcattgtga ccatttgatt
     8761 caagcatata aaggtgcaaa agaagatgtt gcgactgcta cgaagaccaa cgaggaggtc
     8821 tataattttc tccgtgatgt ttcttcccgc tatggtatag gtttttggca gccgggggca
     8881 ggcattattc accaggtggt attggagaac tacgcatttc cgggtggaat gatggtaggc
     8941 acggactctc atacgcccaa tgccggaggt ttgggcatgg tggccattgg tgtgggtggt
     9001 gccgatgcgg tggatgtgat gaccggcatg gaatgggaac tgaaaatgcc gcgtctgata
     9061 ggcgtacact tgaagggtaa attgagtggc tgggtagctc ccaaagacgt tattctgaag
     9121 ttggcgggta ttcttactgt aaaaggggga accaatgcca tcattgaata ttttggaccg
     9181 ggaaccgctt cattgtctgc cactggaaag gctaccatct gcaatatggg ggcagaggtg
     9241 ggggcgacta cctccctttt cccttacgat gagcgcatgg gtacttattt gaaggctacc
     9301 ggacgtgaag aagtggcaaa aatggctgct tccgtagctg tcgaccttcg cgccgacgac
     9361 gaagtgctgg caaatccgga aaaatattac gaccgcatca ttgaaataga cctctcgctg
     9421 ttggaaccgt atatcaacgg gccctttacg ccggatgcag caacaccgat atcgaaattt
     9481 gccgaggtag tgataaccaa taactatccc cgccggatgg aagtcggcct gatagggtcg
     9541 tgcaccaatt cgtcctatca ggatttgagc cgtgcggcct cccttgcccg gcaggtaaag
     9601 gaaaagaatt tgaaggttgc ttccccgctg attgtcaatc ccggctcgga gcagatacgt
     9661 gctactgctg aacgcgacgg catgattgcc gctttcgaag atattggcgc aacgataatg
     9721 gcgaatgcct gcggaccttg tattggccag tggaagcgcc atactgatga ccccgaacgc
     9781 aaaaattcca tcgtcacctc ttttaaccgt aattttgcca aacgtgccga cggcaatccc
     9841 aatacttttg cttatgtggc ttctcccgaa attaccatgg cgctgaccat tgcaggcgac
     9901 ctctgtttcg accccttgcg ggatacgctg gtcaatgcca aaggagaggt tgtgaaactg
     9961 tccgaaccag tcggtgagga attgccggca cacggattca tcggaggaca aaaaggatat
    10021 attgctccaa acaagggaca gacggaaatt acggtcaatc ctcattcaca gcgcttgcaa
    10081 ctgctgactc ccttccctgc ctgggatggc atggacttgc tgaatatgcc tttattgatt
    10141 aaagtgcaag ggaaatgtac caccgaccac atctctatgg cggggccatg gctccgtttc
    10201 cggggacatt tggagaatat ttcggacaat atgctgatgg gggctgtcaa tgctttcaat
    10261 ggagagacga acaaggtttg gaaccgctcc accaatacct atggaacagt gtcaggcact
    10321 gcgaagctgt ataaatcaga aggcatccct tccattgtcg ttgccgaaga gaattatggt
    10381 gaaggttcca gccgtgagca tgctgccatg gaaccacgct tcctgaatgt acgcgccatt
    10441 ttggcgaaaa gctttgcccg tatccatgag acgaatttaa agaaacaagg catgttggcg
    10501 ctgaccttta cggataaggc cgattatgac aagattcggg aacgcgacct gatttctgtc
    10561 atggggttga aagattttgc ttcgggacgt acgttgaagg tggttcttca tcacgaggac
    10621 gggagtaaag aaagttttga agtacaacat acgtataacg aacagcagat agcctggttc
    10681 cgggccggtt ctgcacttaa tgcaagatag aatatggaaa aaattactgt accttttatt
    10741 accggcgatg gagtgggagc agaagtgacc ccatccatgc aggctgtcgt gaatgccgct
    10801 gtcaagaaat cctatggtga ccggcgtggc attgaatgga aagaagtgct ggcaggagaa
    10861 cgtgctttcc acgaaaccgg ctcctggttg ccggacgaaa ccatggaagc cttccgcacc
    10921 tataaggtgg gcatcaaagg tcctttgaca actcccgtcg gtggaggtat ccgttctttg
    10981 aacgtagcct tgcgtcagac gctcgatttg tatgtctgcc aacgtccggt acgttggtat
    11041 aagggcattg tttctccact caaagagcca cagaaggtgg atatgtgcgt attccgtgag
    11101 aataccgagg atatttatgc aggcatcgaa tgggaagccg gaactccgga ggctgaaaag
    11161 ttctatcgtt ttctccgtga tgacatgggg gtgacaaaag tccgttttcc cgaaacctcc
    11221 tcgtttggcg tgaagcccgt ttcaagagaa ggaacagagc gcttggtgcg tgccgcctgc
    11281 caatacgccc ttgagcatca tctgccttcc gtgaccttgg tacacaaagg aaacatcatg
    11341 aaatttacgg aaggcggctt caagaagtgg gggtacgaac tggcagaacg tgagtttggt
    11401 aaagaactgg cagaagggcg tctggtcatc aaggactgca ttgccgatgc attcttgcag
    11461 aacacgttgc ttatccccga agaatattcc gtgattgcca cgttgaatct gaacggcgat
    11521 tatgtgtccg accaactggc tgccatggta ggcggcatcg gcattgcacc gggtgcgaat
    11581 atcaactata aaacggggca tgccattttt gaggctactc acgggacggc tccgaacatt
    11641 gccgggaaag acattgtgaa tccctgttcc atcatccttt ccgctgtgat gatgcttgaa
    11701 tatctgggtt ggaaggaagc agcctctctt atagagaacg ccttggagca aagtttcaca
    11761 gaagcccgtg ctactgccga cttggcccgt tttatgccgg gtggcgtctc gctgtccact
    11821 tcggctttca cccgggagat tgtaaggaga atagaaaatg ggaataacga ataaaacgaa
    11881 acgattatga agaaggagta tctgatttac aagctttccg aagatttgaa ggaagctacc
    11941 cggattgaga atgaactgtt caggaagttt gatgtgaagc gcggtttgcg taatgaggac
    12001 ggcacgggag tcttggtggg gttgaccaaa ataggcaatg tggtcggcta tgaacgcatc
    12061 cccggtggag ggctgaagcc tattcccggc aaattgttct accgcggtta tgatgtggat
    12121 gacttggcac acgccatcat caaagagaag cgtttcggtt ttgaggaaat tgcctacttg
    12181 ttgctttccg gtcgcctgcc cgacaaggaa gaactctctt ctttccgtga actcatcaac
    12241 gacaacatgc cgctggagca gaagaccaag atgaatatca ttgaactcga aggaaacaac
    12301 attatgaaca tcctggcgcg cagcgtgctc gagatgtatc gttttgaccc tgatgcagat
    12361 gacacttccc gcgataatct gatgcggcag agcattgagc ttatttcgaa attcccgacc
    12421 atcattgcgt atgcctataa catgcttcgc catgccaccc atggccgttc actgcatatc
    12481 cgccatccgc aggaaaacct ttccattgcc gagaatttcc tctatatgct gaagaaggac
    12541 tacacggagc tggatgcccg cacgctcgac ctgctgctgg ttcttcaggc cgagcacggt
    12601 ggtggtaaca actccacttt taccgtacgt gtcacttctt ctaccgggac ggatacttac
    12661 tcttcgatag cggcaggtat cggttccttg aaagggccgc ttcatggagg tgccaatatc
    12721 caggttgccg atatgttcca ccatctgcag gaaaacattc aggactggac gaatgtggat
    12781 gagattgata cttacttcac ccgcatgctc aacaaggaag cctataacaa gaccggcttg
    12841 atatatggta tcggacatgc cgtctatacc atttccgacc cgcgcgccat tctgctgaaa
    12901 gagcttgccc gcgaccttgc ccgcgaaaaa gggaaagaac gcgagttcgc tttccttgaa
    12961 ctgctcgagg agcgcgccat tgatgtgttt ggccgtgtga agaataatgg caagacggtt
    13021 tcgagtaatg tggatttcta ttcgggcttt gtctacgaga tgattgggct gccgcaggaa
    13081 atcttcacgc ctttgtttgc catggcacgt attgtcggtt ggtgtgcaca tcgcaatgaa
    13141 gaattgaact ttgaaggtaa gcgtattatc cgtcctgcct ataagaatgt tttggatgag
    13201 gtggcttatg tgcccattaa gaaacggtaa ggattagact tgtatctttt taaatcgttc
    13261 catcacgggg aaaaaaatcg ttccaccatg gtggaacgat ttttttctca tggtggaatg
    13321 aaattttact ccatgatgg
//
