LOCUS       c00135_gnlPro..        13075 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|AKHLEHJM_135.
ACCESSION   c00135_gnlPro..
VERSION     c00135_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 12:56:48
            Original ID  :: gnl|Prokka|AKHLEHJM_135
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 22196
            Orig. end    :: 35271
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13075
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[32196:35040]"
                     /cutoff="5000"
                     /detection_rule="(Fer4_7 and TPP_enzyme_C and POR and POR_N
                     and PFOR_II and not (EKR or Fer4_16))"
                     /neighbourhood="10000"
                     /product="porA"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..12844
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="(Fer4_7 and TPP_enzyme_C and POR and POR_N
                     and PFOR_II and not (EKR or Fer4_16))"
                     /neighbourhood="10000"
                     /product="porA"
                     /protocluster_number="1"
     cand_cluster    1..13075
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Fer4_7 and TPP_enzyme_C and POR and
                     POR_N and PFOR_II and not (EKR or Fer4_16))"
                     /kind="single"
                     /product="porA"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13075
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="porA"
                     /region_number="1"
                     /rules="(Fer4_7 and TPP_enzyme_C and POR and POR_N and
                     PFOR_II and not (EKR or Fer4_16))"
                     /tool="gutsmash"
     CDS             563..1240
                     /locus_tag="ctg135_32"
                     /transl_table=11
                     /translation="MSNYYSSNPKLYVGIDCIIFGFNEGELNLLLLKRNFEPAMGEWSL
                     MGGFVQEDESVDDAAKRVLNELTGLEDVYMEQVQAFGAIDRDPGERVVSIVYYALININ
                     EYDKESVQQHNAFWVNINELPALIFDHPQMVEKARKLMQQKASTEPIGFNLLPKLFTLS
                     QLQSLYEAIYGESIDKRNFRKRIAEMDYIEKTDKIDKTGSKRGAALYQFNEKAYRKAPK
                     FKL"
     CDS             1283..1969
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldolase_II"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg135_33"
                     /sec_met_domain="Aldolase_II (E-value: 3.7e-53, bitscore:
                     171.8, seeds: 389, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLEALKDKVFHANLELVKHGLVIFTWGNVSGIDRESGLVVIKPSG
                     VSYDEMKAEDMVVVNLDGKVVEGRLKPSSDTPTHLVLYKAFPEIGGVVHTHSTYATAWA
                     QAGCDIPNIGTTHADYFHDAIPCTADMTKEEVEGAYELETGNVIVKRFEGLNPVHTPGV
                     LVKNHGPFSWGKDAHEAVHNAVVMEQVAKMASIAYAVNPNLTMNPLLIEKHFSRKHGPN
                     AYYGQK"
     CDS             2107..3375
                     /locus_tag="ctg135_34"
                     /transl_table=11
                     /translation="MVKGLNDSGKLPVKVVYKGTVNSSKEVTAAFKAANNDEKCIGVIT
                     WMHTFSPAKMWIHGLQELKKPLLHFHTQFNKEIPWETMDMDFMNLNQSAHGDREFGHIV
                     TRMRKNRKVVVGHWQDEKAQNQIAAWMRVAAAWADAQDMLIIRFGDQMNNVAVTDGDKV
                     SAEQVLGYHVDYYPINDVMTYYNAVSDEDVKALVAEYFKLYDHAPELEDARTEAYTKVW
                     NSAKAEIAIRRVLKDTGAKGFTTNFNDLGDFDQIPGLASQRLMAEGYGFGAEGDWKTAA
                     LYRTTWVMSQGMPKGCSFLEDYTLNFDGEKSAILQAHMLEVCPLIAEQKPKLEVHRLSI
                     GIDSETARLVFTSKQGEGVAATIVDLGNRFRLIVNKVECIKSKPLPKLPVASALWIPMP
                     NLEVALQPGFWPEVHIIPASPTT"
     CDS             3372..3515
                     /locus_tag="ctg135_35"
                     /transl_table=11
                     /translation="LTVEYWEDFAEMAGIEMVVIDENTTISEFKKELRMNEVYYMLNKA
                     LC"
     CDS             complement(3658..3801)
                     /locus_tag="ctg135_36"
                     /transl_table=11
                     /translation="MSTVRRLTDSPKYGFPGDGFVFLVNQNRLDSCGTEFYTKDGLTCL
                     NG"
     CDS             3828..5237
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FGGY_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FGGY_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg135_37"
                     /sec_met_domain="FGGY_C (E-value: 3e-29, bitscore: 93.8,
                     seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="FGGY_N (E-value: 6.8e-13, bitscore: 40.3,
                     seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LQDCYADLRTNVKSLYDTEIETLAAIGVSAMMHGYMAFNEKEEIL
                     VPFRTWRNTNTSQAAAALSELFVYNIPLRWSISHLYQAILDNEEHVPSINYLTTLAGFV
                     HWQITGQKVLGIGDASGMLPIDPITKNYSSEMVDKFDKLIAPKGYDWKLRDILPKVLSA
                     GENAGFLTPEGASRLDVSGHLKAGIPVCPPEGDAGTGMVATNAVKQRTGNVSAGTSSFS
                     MIVLEKELSKPYEMIDMVTTPDGSLVAMVHCNNCTSDLNAWINIFKEYQELMGIPVDMD
                     EIYGKLYNHALTGNADCGGLISYNYISGEPITGLAAGRPLFVRSANDKFNLANFMRTHL
                     YASVGVLKIGNDILFNEEKIRVDRITGHGGLFKTKGVGQRILAAAINSPISVMETAGEG
                     GAWGIALLASYLANNGNDQSLADFLDKHVFTGNAGIEISPTAEDVSGFNTYIESYKAGL
                     PIEEAAVRFKN"
     CDS             complement(5342..5557)
                     /locus_tag="ctg135_38"
                     /transl_table=11
                     /translation="VVFIGKAASRPAKDGYTELLQCIEYVGAITVDVGNIGVFTYPKST
                     IDTSSQMLCKLAVDFFGNDLPALVCV"
     CDS             5561..6805
                     /locus_tag="ctg135_39"
                     /transl_table=11
                     /translation="MDGIGPKENRPKMVNNNWGGTIEDNSFGTHEFLNLCEMLGCEPYI
                     SGNVGSGTVEELAKWVEYMTSEGDSPMARLRRQNGRDKAWKVKYLGVGNESWGCGGSMR
                     PEYYADLYRRYSTYCRNYDGNSLFKIASGASDYDYNWTKVLMDRVGGRMHGLSLHYYTV
                     SGWNGSKGAATQFSKDDYYWTLGKCREIEDVIKKHCTIMDEYDPQKNVALMLDEWGTWW
                     DTEPGTNPGHLYQQNTLRDAFVASLSFDIFHKYTDRLKMANIAQIVNVLQSMILTSGKN
                     MVLTPTYYVFKMYNVHQDATYIPLELNCDMMDVRDNRRIPMVSATASKDPNGKIHISMS
                     NVDADNAQEVTINLSGTKAKKAVGEILTSTNLTDYNSFENPDNVKPVPFKEVKINKDIL
                     KIKLPAKSIVTIELQ"
     CDS             6996..8846
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Transket_pyr"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Transketolase_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg135_40"
                     /sec_met_domain="Transket_pyr (E-value: 3.6e-35, bitscore:
                     112.9, seeds: 81, tool: rule-based-clusters)"
                     /sec_met_domain="Transketolase_N (E-value: 1.1e-93,
                     bitscore: 305.4, seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDNKLMNRAADNIRILAASMVEKANSGHPGGAMGGADFVNVLFS
                     EFLVYDPENPAWEGRDRFFLDPGHMSPMLYSTLALTGKFTLDELKEFRQWGSPTPGHPE
                     RDIMRGIENTSGPLGQGHTFAVGAAIAAKFMKARFEEVMPQTIYAYISDGGIQEEISQG
                     SGRIAGALGLDNLIMFYDANDIQLSTETKDVTIEDTGKKYEAWGWKVIKINGNDPDAIR
                     GALNEAKAEKECPTLIIGHTVMGKGARKADGSSYEADCATHGAPLGGDAYINTIKNLGG
                     DPTNPFVIFPEVAELYAKRATELKKIMAEKYAAKAVWAKANPEKAAKLEMFFSGKAPEV
                     NWAAIEQKAGVATRAASATVLSALATQVENMIVASADLSNSDKTDGFLKKTHAFKKGDF
                     SGAFFQAGVAELTMACCCIGMALHGGVIPACGTFFVFSDYMKPAVRMAALMEVPVKFIW
                     THDAFRVGEDGPTHEPVEQEAQIRLMEKLKNHKGHNSMLVLRPADAEETTVAWKLAMEN
                     TTTPTGLIFSRQNIANLPEGNDYEQAAKGAYIVAGSDENPNIILVASGSEVATLVAGTE
                     LLRKDGIKVRIVSVPSEGLFRSQAPGYQEGIIRVVPRYSA"
     CDS             9096..9533
                     /locus_tag="ctg135_41"
                     /transl_table=11
                     /translation="MKTIGICSDHAGFELKEYVRGWLEAKGWAYKDFGTYSTESCDYPD
                     FAHPLALAVEAGECYPGIAICGSGEGISITLNKHQGIRAALCWTAEIAHLARQHNDANV
                     LVMPGRFISTEEADMIMREFFSTPFEGGRHQRRVDKIPVHL"
     CDS             complement(9703..9981)
                     /locus_tag="ctg135_42"
                     /transl_table=11
                     /translation="LIVHILVVEVQDVHSHLIGMLCRAFGVQVDGILIVVQCLLPVALF
                     PIGISPQVVSFVFAGKVCLQYFVKLLDGLLYISLVDKLFYGIQSFHI"
     CDS             10001..10228
                     /gene_functions="biosynthetic (rule-based-clusters) porA:
                     Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg135_43"
                     /sec_met_domain="Fer4_7 (E-value: 4.8e-13, bitscore: 41.2,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_2 (E-value: 1.1e-08, bitscore: 26.5,
                     seeds: 214, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 1.8e-08, bitscore: 25.9,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 4.2e-06, bitscore: 18.8,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKIKGAIVVDTERCKGCNLCVVACPLNVIALTKEVNVKGYNYAH
                     QILEDTCNGCASCATVCPDGCISVYKIKVE"
     CDS             10248..11333
                     /gene_functions="biosynthetic (rule-based-clusters) porA:
                     PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters) porA:
                     POR_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg135_44"
                     /sec_met_domain="PFOR_II (E-value: 6.6e-28, bitscore: 88.7,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 6.6e-49, bitscore: 158.3,
                     seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEEVVLMKGNEAIAHAAIRCGADGYFGYPITPQSEVLETLAELK
                     PWETTGMVVLQAESEVAAINMVYGGAGSGKMVMTSSSSPGVSLKQEGISYLAGAELPCL
                     IVNVMRGGPGLGTIQPSQADYFQTVKGGGHGDYRLIALAPASVQEMADFVGLAFELAFK
                     YRNPAIILADGVIGQMMEKVVLPVQKPRRTDAEVIEQCPWATTGRTNGRKPNVITSLEL
                     KPEEMEKNNIRFQAKYKQIEENEVRFEEIHCDDADYLIVAFGSMARIGQKAMELAREEG
                     IKVGMLRPITLWPFPTKVIAAYADKVKGMLVTELNAGQMVEDVRLAVNGKVKVEHFGRL
                     GGIVPDPDEIVDALKEKLIKK"
     CDS             11330..11503
                     /locus_tag="ctg135_45"
                     /transl_table=11
                     /translation="MNPDKIRNVLNILFMVLALAAIIIYFAAKDDFKLFIYVCGAAIFV
                     KLMEFFIRFTNR"
     CDS             11572..12276
                     /gene_functions="biosynthetic (rule-based-clusters) porA:
                     TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg135_46"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.9e-26, bitscore:
                     83.7, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDNPMHYCPGCSHGVVHKLVAEVIEEMGLEDKAIGISPVGCAVF
                     IYNYIDIDWQEAAHGRAPALATAIKRLWPDRLVFTYQGDGDLACIGTAETIHALNRGEN
                     ITIIFINNAIYGMTGGQMAPTTLVGMKTSTSPYGRDVHLHGYPLKMADIAAQLEGTAYV
                     TRQSVQSVPAIRKAKKAIRKAFENSMAGKGSNLVEIVSTCNSGWKMSPAKSNEWMVENM
                     FPFYPLGDLKDK"
     CDS             12299..12844
                     /gene_functions="biosynthetic (rule-based-clusters) porA:
                     POR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg135_47"
                     /sec_met_domain="POR (E-value: 3.7e-36, bitscore: 116.4,
                     seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEEIIIAGFGGQGVLSMGKILAYSGLMEGKEVTWMPAYGPEQRG
                     GTANVTVIVSDEKISSPILSKYDAAIILNQPSLEKFESKVKPGGVLIYDGYGIINSPTR
                     KDIHVYRINAMDAANEMNNAKAFNMIVLGGLLKIKPMVTLDSVLRGLKKTLPERHHHLI
                     PMNEEAIKKGMELIQEMK"
     CDS             complement(12949..13074)
                     /locus_tag="ctg135_48"
                     /transl_table=11
                     /translation="FKRRIIRLHPMVIMGSLVFCFALYCFRFSALESMLWGLEMK"
ORIGIN
        1 gcgattgtga tattgggtat actctggatt cccattatgc gcagtgtagg cgatgtactt
       61 tacacctact tacaagatgt acaatctgta ttagcaccag gcattgccgc agccttcctc
      121 ttggggatct gctggaaacg cacctctgca caaggcggta tgtggggact gattgccgga
      181 atgattatcg gtttaacccg tctgggggca aaagtatatt acagcaatgt aggagatgtg
      241 tcaagcagta ccttcaagta tctgttctat gatatgaact ggctgttttt ctgcggatgg
      301 atgttcttgt tctgcatcgt agtggttatc gcagtcagca tgtttacagc tgccccaagc
      361 gctgaaaaga ttcaaggctg gtattcggaa cttcaactcc tgaacaaaaa gcagctacac
      421 gtgcgagttg gaataaatgg gatatcattc atacccttat catcctgggt attactgctg
      481 ctttttattg gtatttctgg taaatcggta tgttgctatg atatatatcc atgcagcata
      541 ccccttaaac aaaaattaag atatgagtaa ttactatagt tcaaatccga aactttatgt
      601 aggtatcgac tgcattattt tcggtttcaa tgaaggagaa ttgaacctgc tgttgctgaa
      661 gcgtaacttc gaaccggcaa tgggcgaatg gtcgctgatg ggtggattcg tgcaggaaga
      721 cgaaagcgtg gatgatgcag ccaaacgagt cctgaatgaa ctaaccggac tggaagatgt
      781 atatatggaa caagtccaag ctttcggagc catagatcgt gacccaggag aacgcgtagt
      841 ctccattgtt tactatgcgc tcatcaacat caacgaatac gacaaagaat ccgtacagca
      901 acacaatgct ttctgggtaa atatcaatga actgccagcg ctaatctttg atcatccgca
      961 aatggtggag aaagctcgga agttgatgca acaaaaagcg tccaccgaac caatcggctt
     1021 taatctacta cctaaactgt tcacgctgtc acaactgcaa agcttatacg aagctatata
     1081 cggcgagagc attgacaaac ggaacttccg aaaacgcata gcagaaatgg actatataga
     1141 aaaaactgac aaaatagaca aaacggggtc caaacgtgga gctgctttat atcagtttaa
     1201 tgagaaggca taccgcaaag ctccgaaatt taagctctga gaacctaata ttcaacaact
     1261 tgtaattagt aatttaaata atatgctgga agcactgaaa gacaaagtat tccatgctaa
     1321 ccttgaactg gtgaagcacg gattggttat cttcacatgg ggcaatgtat cgggcattga
     1381 ccgcgaatct ggtctggtag tcatcaagcc cagtggggtg agttacgatg aaatgaaagc
     1441 agaggatatg gtggtagtga atcttgacgg caaggtcgtg gaaggacggt taaagccctc
     1501 ttcagacacg ccgacccacc tggttctcta taaagcattc cccgaaatcg gcggtgtggt
     1561 gcacacgcac tctacttacg ccacagcctg ggcacaagcc ggatgtgaca taccgaatat
     1621 cgggacaaca catgccgatt acttccacga cgccataccc tgcacagcag acatgacgaa
     1681 ggaggaagtg gaaggagcgt atgaactgga aacgggaaat gtcatcgtaa aacgctttga
     1741 ggggctgaac ccggtacata ctcccggagt attggtaaag aaccacggtc ctttctcgtg
     1801 gggaaaagac gcacacgaag cggtacataa tgccgtagtg atggagcagg tggcaaaaat
     1861 ggcaagtata gcctatgccg tgaaccccaa tctgaccatg aatccgttac tgatagaaaa
     1921 gcatttcagc cgcaagcacg gtcctaacgc ttattatgga cagaaataac tatcattctt
     1981 taaatataaa ctataaaaat aaattgtatg aacgcatttg aacaatatga agtatggttc
     2041 gtaaccggag cacagctctt gtacggaggt gacgcagtta tcgcggtaga cgcacatagc
     2101 aatgaaatgg tgaaaggtct gaatgattcc gggaaactgc ccgtaaaggt agtatataaa
     2161 ggtacggtca attcatccaa agaagtaact gctgccttca aggccgccaa caacgacgaa
     2221 aagtgtatcg gggtcatcac ctggatgcac accttctctc ctgccaaaat gtggattcac
     2281 ggtttgcagg aactgaagaa gccattacta cacttccata cacagttcaa caaggaaatt
     2341 ccctgggaga cgatggacat ggattttatg aacctgaacc aatcggctca cggcgaccgc
     2401 gagttcggac acattgtgac acgtatgcga aagaaccgca aagtggtagt aggccactgg
     2461 caggacgaaa aagcccaaaa ccagattgcc gcatggatgc gcgtagctgc cgcatgggct
     2521 gatgcgcagg atatgctcat catccgcttc ggcgaccaga tgaacaacgt ggctgtgaca
     2581 gacggtgaca aggtcagcgc cgaacaggta ttgggctatc atgtggacta ctatcccatc
     2641 aatgatgtga tgacatacta caatgctgtc agcgacgagg acgtgaaggc actcgtagca
     2701 gaatacttca agctctacga ccacgctccc gaactggaag acgcacgtac ggaagcctac
     2761 accaaagtat ggaactccgc caaggccgaa atcgccattc gccgcgtgct gaaagacacg
     2821 ggtgccaaag gcttcaccac caacttcaac gatttgggcg actttgacca aatccccgga
     2881 ctggcctcac agcgactgat ggcagaaggt tacggcttcg gtgccgaagg cgactggaaa
     2941 actgcagcac tgtaccgtac cacttgggtg atgagtcaag gtatgccgaa ggggtgctcc
     3001 ttccttgaag actatacgct gaacttcgac ggagaaaaga gcgccatcct gcaagcacat
     3061 atgttggaag tctgtccact gattgccgaa cagaagccga aactggaagt gcaccgtctg
     3121 agcatcggta tcgacagcga aacagcccgc ctggtattta ccagcaagca aggtgaaggt
     3181 gtagccgcta ccatcgtaga cctgggcaac cgcttccgcc tcattgtgaa caaagtagaa
     3241 tgcatcaaga gcaagcctct gcccaagttg cccgttgcca gtgcactgtg gattccaatg
     3301 cccaacctcg aggtggcgct gcagcctgga ttctggccgg aggtacacat cataccagct
     3361 tctcctacga cttgacggtg gaatattggg aagactttgc cgaaatggcc ggcatcgaaa
     3421 tggtggttat cgatgaaaat accaccatta gcgagttcaa aaaagaattg cgtatgaatg
     3481 aagtctacta tatgctgaac aaggcacttt gctgataatc attacagatt accgattgcg
     3541 gactactaat tacacgtacc acaaacgtaa ctagtagttt gcaatcagta atccgtagtt
     3601 tataatcgta ctataaatcc gtaatttatc attaatacca tgaaattaga tgcaaaatca
     3661 accattgagg caggtaaggc catccttggt atagaactcg gttccacacg aatcaaggcg
     3721 gttttgattg accaggaaaa caaacccatc gccagggaag ccatacttgg gagaatcagt
     3781 tagtcgacgg actgtggaca tatagcgtcg aggctgtctg gtatgggttg caggattgct
     3841 acgcagacct tcgtaccaat gtaaagagcc tctacgatac agagatagaa accctggcag
     3901 ccatcggtgt cagtgccatg atgcacggct atatggcatt caatgaaaaa gaagaaatcc
     3961 ttgtaccctt ccgtacctgg agaaatacta ataccagcca ggctgccgca gccctatccg
     4021 aactatttgt ctacaacatc cctctgcgtt ggagtatctc ccacctctac caagccatcc
     4081 tggataatga agagcacgtt ccatccatca attacctgac cacccttgca ggttttgtcc
     4141 actggcaaat aaccggccaa aaggtactgg gcataggaga tgcctccggt atgctcccca
     4201 tcgatcccat caccaaaaac tattcttctg aaatggtgga taagttcgac aaacttattg
     4261 ctccgaaagg atacgactgg aaacttcggg atattctgcc gaaggtattg tcggccggtg
     4321 aaaacgcagg cttccttact cccgaaggag ccagtcgcct cgacgtatcg ggacatctga
     4381 aagcaggaat tcccgtctgt ccacccgaag gtgacgctgg aaccggcatg gttgccacca
     4441 acgccgtaaa gcagcgcact ggaaacgtat cggcaggcac ctcctctttc tcaatgattg
     4501 tattggaaaa agaattgtcc aagccctacg aaatgattga catggtaacc acccccgacg
     4561 gaagcctcgt agctatggtg cattgcaaca actgcacttc cgacctcaat gcctggatca
     4621 atattttcaa agaataccag gaactgatgg gtatccccgt agatatggac gaaatctacg
     4681 gaaaactcta taaccacgcc ctgacaggca atgcagattg cggaggcctc atctcttaca
     4741 actacatatc aggcgagcct ataacgggac tggcagccgg acgtccactg tttgtacgtt
     4801 cggcaaacga caagttcaac cttgccaact tcatgcgcac ccatctgtat gcttcagtgg
     4861 gagttctcaa aatcggcaac gacatccttt tcaatgaaga gaaaatcaga gtagacagaa
     4921 tcaccggtca cggaggactc ttcaaaacca aaggagtagg ccagagaata ctggcagctg
     4981 ccatcaattc acccatttcc gttatggaaa cagccggcga aggtggtgcc tggggtattg
     5041 ccctcctcgc ttcctacctt gcaaacaacg gaaacgacca atcccttgcc gacttcctgg
     5101 acaagcatgt attcaccgga aatgccggta ttgaaatctc accgacagcc gaagatgtaa
     5161 gcggattcaa cacctacatc gaaagctata aagctggttt gcccatcgaa gaagcagcag
     5221 taagattcaa gaactaagta tttaataaca ctaaaaaact atgaacacaa agttatttat
     5281 cagtagcata tttctctcca cctcgttgtc actcttcgca cagaaaagtg ccactatcac
     5341 tttacacaca gaccagagcg ggcaaatcat tcccaaagaa atctacggcc aatttgcaga
     5401 gcatttggga acttgtatct atggtggact ttgggtaggt gaaaactccg atattcccaa
     5461 catcaacggt tatcgcaccg acgtattcaa tgcactgaag gagctccgtg tacccgtcct
     5521 tcgctggccg ggaggctgct ttgccgatga ataccactgg atggacggta tcggccctaa
     5581 agaaaaccgc cccaaaatgg tgaacaacaa ctggggaggc actatcgaag acaacagttt
     5641 cggaacccat gagttcctca atctctgcga aatgctggga tgtgaaccct atatcagtgg
     5701 aaacgtaggc agtggtaccg tagaagaact tgccaaatgg gtggaataca tgacctccga
     5761 aggagactcc cccatggcac gcctgcgccg ccagaacggt cgcgacaaag cctggaaagt
     5821 aaaatacctc ggcgtgggta acgaaagctg gggttgcggt ggaagcatgc gtcccgaata
     5881 ttatgccgac ctctaccgcc gctattccac ctactgccgc aactatgacg gcaatagtct
     5941 tttcaagata gccagcggtg ccagcgacta cgactataac tggaccaaag tgctgatgga
     6001 ccgcgtaggc ggccgtatgc acggtctttc cttgcactac tataccgtca gcggatggaa
     6061 cggcagtaaa ggcgccgcca cccaattcag taaagacgac tattactgga cactgggcaa
     6121 atgccgcgaa atagaagatg tcatcaagaa gcattgcacc attatggatg aatacgaccc
     6181 tcaaaagaac gtggctctta tgcttgacga atggggaacc tggtgggaca ctgaaccggg
     6241 taccaatccc ggacatctgt accaacagaa tacattgcgt gatgcttttg tcgcttccct
     6301 cagcttcgac atcttccata aatataccga ccgtctgaaa atggcaaaca ttgcccaaat
     6361 cgtcaatgta ttgcaatcca tgattctgac cagcggaaaa aacatggtac tcacccccac
     6421 ttattatgta ttcaaaatgt acaatgtaca ccaggatgcc acctacattc ctcttgagct
     6481 gaactgcgac atgatggatg tacgcgacaa ccgcagaata ccaatggtca gcgctaccgc
     6541 ctccaaagac ccaaacggca agatacacat ttccatgtcc aacgtagatg cagacaatgc
     6601 acaggaagtg accatcaatc tgtctggaac gaaagccaag aaagcagttg gtgaaatatt
     6661 gacttccacc aatctgacgg actacaattc atttgaaaat cccgacaatg tgaaacccgt
     6721 tccgttcaaa gaggtaaaaa tcaataaaga tattctcaag attaaacttc cggccaaatc
     6781 aatcgttact attgagttac agtaaaacta ccgtgcaccg cacaaaatca gctaaatacg
     6841 tttagtatca ttttagcagc aaaaaggcag taatactgat aaaaaagaca ctcttcgagt
     6901 gttgtgaatt acgcataaag agttatcttt gcccttggaa aacctacaag gaccaaataa
     6961 cctattgata atattcaaaa ttaattagat tcaatatgaa cgacaacaaa cttatgaacc
     7021 gtgcggcgga caatatccgt atccttgctg catccatggt tgagaaagcc aactccgggc
     7081 atccgggcgg tgccatgggt ggtgctgact ttgtaaatgt actcttctca gagttcctgg
     7141 tatatgaccc tgaaaatccg gcttgggaag gtcgtgaccg tttcttcctc gacccgggac
     7201 acatgtcacc gatgctttac tctacattgg ccctgaccgg caagttcacg ctggacgaac
     7261 tgaaagagtt ccgccaatgg ggaagcccta ctccgggaca tcccgaacgt gacatcatgc
     7321 gcggcatcga aaacacttcc ggaccgctcg gccagggaca cacatttgca gtcggtgcag
     7381 ccatcgcagc caagttcatg aaggcacgtt tcgaagaagt aatgccacag accatctacg
     7441 cttatatttc tgacggtggc atccaggaag aaatctccca aggctcaggc cgtatcgccg
     7501 gagcattagg gttggataat ctcatcatgt tctatgatgc caacgacatt cagctttcta
     7561 ccgagacaaa ggatgtgacc atcgaagata ccggcaagaa atacgaagct tggggctgga
     7621 aagtcattaa aatcaatggt aacgatcccg atgccatccg cggtgcactg aacgaagcca
     7681 aagctgagaa agagtgtccg acgctgatta tcggccatac cgtaatgggt aaaggtgccc
     7741 gcaaggcaga cggcagcagc tacgaagctg attgtgccac gcacggtgct cctctgggcg
     7801 gcgacgctta tataaacact atcaagaatt tgggtggtga cccgacaaat ccgtttgtca
     7861 tcttccccga agtggccgaa ctatatgcca agcgtgcaac tgagctgaag aaaatcatgg
     7921 ctgaaaagta tgcagccaaa gccgtatggg caaaagccaa tccggaaaag gctgccaaac
     7981 tggaaatgtt cttctccggc aaggctcccg aagtgaattg ggccgccatc gaacagaaag
     8041 caggcgttgc cacccgcgca gcatctgcca ctgtgctcag tgctctcgcc actcaagtag
     8101 aaaatatgat tgttgcttct gccgaccttt ccaattccga caagacagac ggattcctca
     8161 agaaaacaca tgccttcaag aaaggtgact tcagcggtgc attcttccag gccggtgttg
     8221 ccgagctgac tatggcatgt tgctgtatcg gtatggcact gcatggcggt gtaatccccg
     8281 cttgcggaac tttcttcgta ttctccgact acatgaaacc tgccgtacgt atggcagccc
     8341 tgatggaagt tcccgtgaag ttcatctgga cacacgatgc cttccgtgta ggtgaagacg
     8401 gtcctaccca tgaaccggta gagcaggaag cccaaatccg cctgatggaa aaactgaaaa
     8461 accacaaggg acataattcc atgttggtac tccgcccggc agatgcagaa gaaacaactg
     8521 tggcatggaa actggcaatg gaaaatacca caaccccaac cggtttgatt ttctcccgcc
     8581 agaacatcgc caacctgccc gaaggcaacg attacgaaca agctgccaaa ggcgcttata
     8641 ttgtagccgg ctccgatgaa aatccaaata taatcctcgt tgcttcaggc tcggaagttg
     8701 ccacattggt agccggtact gaattgctgc gcaaggatgg catcaaggtg cgtatcgtgt
     8761 ccgttccttc cgaaggtctg ttccgtagcc aagctccggg atatcaagaa ggcattatcc
     8821 gtgtggtgcc aaggtattcg gcctgacagc cggtctgccc gtcacactgc aagggctggt
     8881 aggtccccgc ggtaaagtat ggggattgga atcattcgga ttctcggcac cttataaagt
     8941 gctggacgaa aagctcggtt tcaccgcaga gaacgtttac aaacaagtaa aagcaatgtt
     9001 ataatcatta tccaatgtgc tgatgtgctg attgcccgcg ccctacaagc tgcaggcatc
     9061 agcacattgg cacattggta tattaactga ccatcatgaa aacaatagga atctgttccg
     9121 accatgcagg cttcgaattg aaggaatatg ttcgcggctg gttggaagcc aaaggctggg
     9181 cttacaagga cttcgggacc tactcaaccg agagttgcga ctatcccgac tttgcacatc
     9241 ctttggcact ggccgttgaa gccggagagt gctatccggg aattgccatc tgcggaagcg
     9301 gtgaaggtat cagcataacg ctgaacaagc atcagggtat ccgcgcagcc ctctgctgga
     9361 cggcagaaat agcccatttg gcacgccagc acaatgatgc caatgtgctt gtcatgccag
     9421 ggcgattcat cagtaccgaa gaagccgaca tgattatgag ggaattcttc agtacaccat
     9481 tcgaaggcgg acgccaccaa cgaagagtgg acaagatacc ggtacacttg taaagcaata
     9541 gaatcacctt ctttatgata tccgcccgaa gctctgacat tctgatagaa tcgtgagaaa
     9601 cttcgggctt tttatttgcc cctttttctt atttttcaca gtgaagatgc tcattgtctt
     9661 caaataaaaa ctatctttgt ggttcgataa cccggatatt ttttagatat ggaacgactg
     9721 aataccataa aagagcttat caaccaggga aatgtagagc aagccatcca gcagcttgac
     9781 gaaatactgc aaacagactt tcccggcaaa gacgaagctt actacctgcg gggaaatgcc
     9841 tatcggaaac aaggcaactg gcaacaagca ctgaacaact atcagtatgc catcgacctg
     9901 aaccccgaaa gcccggcaca acatgcctat caaatggcta tggacatcct gaacttctac
     9961 aacaaggata tgtacaatca ataaataaag aacgtaaatt atggcaaaaa tcaaaggagc
    10021 aatcgtagta gacaccgaac gttgcaaagg ctgcaacttg tgtgtggtag cgtgtccgct
    10081 caacgtaata gccctcacca aggaggtgaa tgtgaaaggg tataactatg cccaccaaat
    10141 attggaagat acttgtaacg gctgcgcctc gtgcgccaca gtatgtccgg acggatgtat
    10201 ctcagtatat aaaataaaag tagaataaat ctgtaaatca gtagaatatg gcagaagaag
    10261 ttgtattaat gaaaggaaac gaagccatcg cccacgcagc catccgttgc ggtgcagacg
    10321 gttacttcgg atatcccatt actccgcaat cggaggtatt ggaaactctt gccgaactga
    10381 aaccctggga gacgaccggc atggtggttc ttcaggcaga aagtgaagtg gcagctatca
    10441 atatggtgta cggcggtgcc ggaagtggta aaatggtcat gacctcctcc tccagccccg
    10501 gtgtcagcct aaagcaggaa ggtatctctt atctggcagg tgccgagctg ccttgcttga
    10561 ttgtaaacgt tatgcgcggc ggtcccggtc tgggaaccat ccaaccgagc caggccgact
    10621 atttccagac agtaaaagga ggcggccacg gtgactatcg tctgattgcc cttgctccgg
    10681 cttccgtaca agaaatggca gatttcgtag gactggcatt cgaacttgcc ttcaaatacc
    10741 gtaatccggc aatcatcctt gccgacggtg tcatcggcca gatgatggaa aaagtggtgc
    10801 tcccggtaca aaagccacgc cgcaccgatg cggaagtcat cgaacaatgc ccatgggcca
    10861 ctaccggcag aaccaatggc cgcaaaccca acgtcatcac ctcattggaa ctgaaaccgg
    10921 aagaaatgga aaagaacaac atccgtttcc aggccaaata caagcagata gaagagaatg
    10981 aggttcgctt cgaggaaatt cattgcgatg atgccgacta cctgattgta gccttcggct
    11041 ctatggcacg catcggacag aaagcaatgg agctggcacg cgaagaagga ataaaggtag
    11101 gtatgctccg ccccatcacg ttgtggccgt tcccgaccaa agtcattgcc gcgtatgccg
    11161 acaaggtgaa aggtatgctc gttacagaat tgaatgccgg acagatggtg gaagatgtcc
    11221 gccttgccgt gaacggtaaa gtgaaagtgg aacatttcgg acgcctcggc ggcattgttc
    11281 ccgatccgga tgagatagta gatgcattga aagaaaaact gattaagaaa tgaatcctga
    11341 taaaataaga aacgtactga acattctctt catggtactt gccctggcag ctatcattat
    11401 atattttgct gcaaaagatg acttcaagct gttcatctac gtctgcggcg cggcgatatt
    11461 cgtcaagttg atggagtttt tcatacggtt caccaacaga taggagaagt gattatgaca
    11521 aaagaagata ttataaagcc cgagaatctg gttgccaaga aaccgactct gatgaacgac
    11581 aatcccatgc actactgccc gggatgcagt cacggcgtag ttcataaact cgtagccgaa
    11641 gttatcgaag aaatgggact ggaagacaaa gcaataggca tctcccccgt gggatgtgcc
    11701 gtgttcatct ataattatat agacatcgac tggcaggaag ccgcccatgg acgtgcgccc
    11761 gcacttgcca ctgccatcaa gcgcctttgg ccagaccgcc tggtgttcac ttaccaagga
    11821 gacggcgacc tggcttgtat cggtactgcc gaaaccatcc acgccttgaa ccgcggcgaa
    11881 aacatcacca tcatcttcat caacaatgcc atctatggta tgaccggggg acaaatggct
    11941 cccactaccc ttgtaggcat gaagacatcg accagccctt acggacgtga cgtgcatctg
    12001 cacggctatc cgctgaagat ggccgatatt gctgcacaat tggaaggaac cgcttacgtg
    12061 acacgccaaa gcgtacagtc cgttcccgcc atccgcaaag cgaaaaaggc tatccgcaaa
    12121 gcattcgaga actctatggc aggcaaaggt tccaaccttg tggaaatcgt ttccacctgt
    12181 aactccggct ggaagatgtc tcctgcgaaa tccaatgaat ggatggtaga gaacatgttc
    12241 cccttctatc cgctgggcga cctgaaagat aaataatcat gctaaagaca gaagaacaat
    12301 gaaagaagaa atcattatag caggcttcgg tggacaaggt gtattgtcca tgggaaagat
    12361 tttggcatat tccggattga tggaaggcaa agaggtgact tggatgccgg cttacggacc
    12421 ggaacaacgt ggtggtacag ccaacgtaac agtcatcgta agtgacgaga aaatatcctc
    12481 acccatctta agcaagtacg atgccgccat catcctgaac cagccgtcat tggagaaatt
    12541 cgaaagcaag gtaaaacccg gaggcgtact tatctacgac ggttacggca tcatcaactc
    12601 gccgacgcgt aaggacatcc acgtttaccg catcaacgcc atggatgccg ccaatgaaat
    12661 gaacaatgcc aaggcgttca acatgattgt attgggtgga ttattgaaaa tcaagccgat
    12721 ggttacactg gacagtgtac tcagaggatt gaagaagaca ctgcccgaac gccaccatca
    12781 cttgataccg atgaacgaag aagctatcaa gaaaggaatg gaacttattc aggaaatgaa
    12841 atgaaaggct gtgtaaagcc actcccccat aagaggagaa actttacgcc agaataagag
    12901 ataaaggaaa gcggataagc cctttgtgat attgatttat tgcaaggctt atttcatttc
    12961 aagcccccaa agcatggatt caagggcaga gaaccggaag cagtataggg caaaacagaa
    13021 aacaaggctt cccataatca ccataggatg caggcgaatg atacggcgtt tgaaa
//
