LOCUS       c00346_gnlPro..        14097 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|AKHLEHJM_346.
ACCESSION   c00346_gnlPro..
VERSION     c00346_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 12:56:48
            Original ID  :: gnl|Prokka|AKHLEHJM_346
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 13064
            Orig. end    :: 27161
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14097
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[23064:26535]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13471
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..14097
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14097
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             complement(1630..1803)
                     /locus_tag="ctg346_19"
                     /transl_table=11
                     /translation="METFGNGCGTVCQAIGTQKNEEQSSDKKQYIHRYVNFEYKDNANR
                     IQNFHVCMKKLC"
     CDS             1918..2688
                     /locus_tag="ctg346_20"
                     /transl_table=11
                     /translation="VVGSNTFNTLMIVGCTALFAPIAITRNTLKREIPLCILSSFALLI
                     CANDVLLDSSGENILSITDGLLLLCFFTIFLSYTFAIAKRDGSMKEPEKKHLQEEDEIR
                     LLPAWKSALYILGGLAGLIIGGNFFVDGASGIARGLGVSESIIGLTLVAGGTSLPELAT
                     SIVAALKKNPEIAIGNVIGSNLFNIFFVLGCSASITPLRLTGITNFDLWVLVGSSILLW
                     LFGIFFGKRIITRVEGSILILCYIAYTAVLIYNL"
     CDS             complement(2908..3561)
                     /locus_tag="ctg346_21"
                     /transl_table=11
                     /translation="LVNLPLAQCRIAIEWLIGFVHQFEDGLTVVLGNLLGRCVFLYLEV
                     ILALDEVGDALVLVGYGVGNVDFVLHPIGILLKAHAFQMLRIVGIVINGGHGAELVESF
                     DEHTFGIEICESQRALYMCHSPFFSPFFHGANQGIGDFRIIDEVYPAEADFLFVPGLVC
                     LVVDDGSYTSYDFTFPISQEIVGFTKFECSVFLLVEGVEHVIEKVGDGIRVVFV"
     CDS             3571..3975
                     /locus_tag="ctg346_22"
                     /transl_table=11
                     /translation="MYLPILDLRMVTLITDADDQLLAVGISMPSLAEALQKAHGRLLPM
                     GWYHLAKTIFLKKYPKMLDLLLVAVKPEYQNKGVNALLFSDLIPVYQQLGFEYAESNPE
                     LELNGKVQAQWEYFKTEQHKRRRCFVKGIK"
     CDS             4111..5790
                     /locus_tag="ctg346_23"
                     /transl_table=11
                     /translation="MTLPLEEADNNITESPVSSVEYTDDNIRHLDDMEHIRVRSGMYIG
                     RLGDGSQNDDGIYVLLKEVMDNSIDEFKMGAGKRIEVTIEDSLRVSVRDYGRGIPQGKL
                     VEAVSKLNTGGKYDSKAFKKSVGLNGVGIKAVNALSSRFEVRSYRDGKVRIAIFEKGTL
                     LSDVTEDSTEESGTYIFFEPDATLFLNYSFQNQFVETLLRNYTYLNTGLTFIYNGQRIV
                     SRHGLEDLLKDNMTSEGLYDIIHLKGEDIEIAFTHTNQYGEEYYSFVNGQHTTQGGTHQ
                     TALKEHIARTIKEFYNKNQEYADIRNGLVAAIAIDVEEPMFESQTKTKLGSNNMWPAAP
                     QEHKPAGPTVNKYVGDFIKTEVDNYLHKNPLVAEVMLQKIQDSEKERKAIAGVTKLARE
                     RAKKANLHNRKLRDCRYHLSDGKGKDQETESCIFITEGDSASGSITKSRDVNTQAVFSL
                     RGKPLNSYGLTKKVVYENEEFNLLQAALNIEDGIETLRYNKVIVATDADVDGMHIRLLI
                     ITFFLQFFPDLIKKGMYISCKPLSSACATKRRQVIAIQRRNV"
     CDS             5787..6026
                     /locus_tag="ctg346_24"
                     /transl_table=11
                     /translation="VKAIEELGPNPEITRFKGLGEISPDEFKHFIGKDMRLEQVSLRKT
                     DLVKELLEFYMGKNTMERQNFIINNLVIEEDLAS"
     CDS             6023..6481
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CTP_transf_like"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg346_25"
                     /sec_met_domain="CTP_transf_like (E-value: 1.6e-18,
                     bitscore: 58.6, seeds: 65, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRAIFPGTFDPFTIGHSSVVSRALTFIDEIVIGIGINENKNTYF
                     PLEKREQMIRDYYRNEPRIIVQSYDCLTIDFARQVDASLIIRGIRTVKDFEYEETIADI
                     NRKLTGIETILLFTEPELTCVSSTTVRELLQYGKDISMFIPEGMEIRD"
     CDS             6525..8147
                     /locus_tag="ctg346_26"
                     /transl_table=11
                     /translation="MEMMKKLFTIIICICAVTAQAQKPNNEALRKLQMAEFAITNLYVD
                     KVDEDKLVEEAIIKMLAQLDPHSTYNNAEEVKKMNEPLQGNFEGIGVQFQMIEDTLLVI
                     QPVSNGPSEKVGILAGDRIVAVNDSAIAGVKMSTEDIMSRLRGPKDSEVKLTIVRRGVD
                     DQLYFTVKRDKIPILSLDASYMIQPKTGYIRINRFGATTAEEFAEALKSLQKKGMKDLI
                     LDLQGNGGGYLNAAIDLANEFLKQKELIVYTEGRAARRSDFFAKGTGNFKNGRLIILVD
                     EYSASASEIVTGAIQDWDRGVVVGRRTFGKGLVQRPIDLPDGSMIRLTIARYYTPSGRC
                     IQKPYDSTANLDGRLTGENSQDKYNQELIDRFNHGEMIHADSIHFADSLKAQTKRMGRT
                     VYGGGGIMPDFFVPIDTTQYTDYHRNLVAKGVVIKATTGYIEKHRKELQNKYKKFEAFN
                     EKFEIDDNFLAEIRTLADKEKIKFDEKQYNQSLPLIKTQLKALIARDLWDMNEYFQVMN
                     STNQSVQQALKVLNEGIYSTIIQ"
     CDS             complement(8126..8233)
                     /locus_tag="ctg346_27"
                     /transl_table=11
                     /translation="MILGANYAEYAELDKLNPHNPRLSLFQVGYWIIVL"
     CDS             complement(8230..8403)
                     /locus_tag="ctg346_28"
                     /transl_table=11
                     /translation="MVCDSSVCLWACSVGVSRMNEGVHYPSDVLAGAAIGAGCAVVNIY
                     VNKWLNKWLFGE"
     CDS             8454..8693
                     /locus_tag="ctg346_29"
                     /transl_table=11
                     /translation="MSGRKRRAAFMAICMHSVGIFIIRTLTVHQIFHSISHNKSPRYTC
                     TYVDRIFQQTLIMFYPSGNRHRHRNTDSNIGLRT"
     CDS             9069..9329
                     /locus_tag="ctg346_30"
                     /transl_table=11
                     /translation="MIFMLKGELLVNSDEYPGTTLQSRQLILQAIGSKVELLALTEVEY
                     IVYWFTELPLICEERYKEILKRSEAPLTYTPLSAISMLEGS"
     CDS             9386..9838
                     /locus_tag="ctg346_31"
                     /transl_table=11
                     /translation="MKCQELVYILTCYYPLHQISTFFYPISTYTESFQYFVMQNYDKVK
                     NVEEFAHLGGYTTTTFRRLFKNMYGVPVYEWILDKKREGILNDLQYTKQRISVISARYG
                     FDSLSHFAHFCKDSFGDTPRALRKRSANGEKISIICKEQGKDQEDE"
     CDS             10001..10699
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg346_32"
                     /sec_met_domain="SucD_FumR (E-value: 2.6e-129, bitscore:
                     419.9, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWLSNSSVGRKVVMSVTGIALVLFLTFHMAMNLVALVSANGYNMV
                     CEFLGANWYALVATVGLAALFIIHIIYAFWLTMQNRKARGSERYAVTEKPKTVEWASQN
                     MLVLGIIVIVGLGLHLVNFWAKMQLPELMHNMGMHADTLTLAYAANGVYHIQNTFSNPV
                     FVVLYLVWLGALWFHLTHGFWSSMQSLGWNNKVWINRWKCISNIYSTIVVLCFALVVVV
                     FFAKSLCGAC"
     CDS             complement(10811..11875)
                     /locus_tag="ctg346_33"
                     /transl_table=11
                     /translation="LCNDIFTQTVDSFGEVKEYGKTGVVHAEALVAAFFGSAAGNVTRN
                     EVTECRITAFQVVVAVFLGNIFSLQCTFLQFLGIFQLLRNPDTTIVTQRFGHQSQLRLL
                     VAVNRDTSGVNLYVSRVGKPGTFTVASHCCRAVTCHCIGRKEVGIAVTTGSDYHSVGGK
                     TFQFTGNEVLCNDTAGTSVNEDNVFHFVAGIQFHSAYVHLAAQCRVCTQQQLLSGLTLG
                     IESTGYLSTTERTVVQCTAVFAGERNTLCNALVDNIVGYFSQTVNVSFAGTVVATLYCI
                     VEQTVYRVTVVLVILSSIDTTLCSDGVCTARRVLDAEVEYSETHFAQRGGSTGTGKSGS
                     YYDDVQTTLVGRVH"
     CDS             11897..12682
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg346_34"
                     /sec_met_domain="FAD_binding_2 (E-value: 5.8e-14, bitscore:
                     43.2, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 4.6e-38,
                     bitscore: 121.5, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYEEITDVSPYENPMMIYPAIHYTMGGIWVDYELMTSIKGLFAIG
                     ECNFSDHGANRLGASALMQGLADGYFVLPYTIQNYLADQITVPRFSTDLPEFAAAEKAV
                     QEKIDWMMNIKGKKSVDSIHKELGHIMWEYVGMGRTAEGLKEGLKKLKEVRKEFEKELF
                     IPGDKEGMNVELDKAIRLYDFITMGELVAYDALNRNESCGGHFREEYQTEEGEAKRDDE
                     NYFYVACWEYQGSDEKEPVLLKEPLVYEAIKVQTRNYKS"
     CDS             12716..13471
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg346_35"
                     /sec_met_domain="Fer4_7 (E-value: 3.3e-12, bitscore: 38.3,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer2_3 (E-value: 1.1e-25, bitscore: 81.2,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 1.3e-06, bitscore: 20.2,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKNISFTLKVWRQKGPKAKGAFETYQMKDIPGDTSFLEMLDILN
                     EQLISEGKEPVVFDHDCREGICGMCSLYINGHPHGPATGATTCQIYMRRFNDGDTITVE
                     PWRSAGFPVIKDLMVDRTAYDKIMQAGGYVSVRTGAPQDANAILIPKPIADEAMDAASC
                     IGCGACVAACKNGSAMLFVSAKVSQLNLLPQGKPEALRRAKAMLSKMDELGFGNCTNTR
                     ACEAECPKNVSISNIARLNRDFIIAKLKD"
     CDS             13518..13700
                     /locus_tag="ctg346_36"
                     /transl_table=11
                     /translation="LSKLRFITQLSLYLINITRDSSAGKPPEEFFYDMPFTSDKLPARK
                     LRGEAPKFFLQKLEK"
     CDS             complement(13610..13798)
                     /locus_tag="ctg346_37"
                     /transl_table=11
                     /translation="MMERRKESVVYELRYTDASISEICYKYGFESLPHFSNFCKKNFGA
                     SPRSLRAGNLSEVNGMS"
     CDS             13817..14035
                     /locus_tag="ctg346_38"
                     /transl_table=11
                     /translation="MKNRIEYTPESSYCISSQLGKFLYRLDFGMILQDKVVEGISILGK
                     RMYQHGKLIVGVDPPNWASSSTVLTLA"
     CDS             14032..14097
                     /locus_tag="ctg346_39"
                     /transl_table=11
                     /translation="MILQDKVVEGISILGKRMYQHG"
ORIGIN
        1 ctctatcaac agctgatgtg tcttccgcca cggaacatcg tagccaatac tgacctccga
       61 atggataatc aatccatact cacgggcaga ctggctgtaa ttgaccgtat gggaagacat
      121 gatgaaagag ttcggaatgg tcaccacctc attcttcgga gtacggatgc gggtgacgag
      181 cggtgttttc tcaatgatgt tgcccgtagt atcgttcagc ttgatgcggt cacccagctt
      241 gaaaggccgc atgtaggtta tgaccagtcc tgcaatgata ttgccgataa ccgtactgga
      301 accgagcgaa acaatcaagc cgacaaacac ggagattccc tggaagactc ccgacttgga
      361 acccggcaga taagggtaaa tcatggcaat cataaacgca taaagcaaga agcgcacaat
      421 atgataggta ggaatggccc aatccggata gaagccgttt atcttcagcc gttcagcctg
      481 cacctcattg gcaagataac gcaccagtct gaccagatac ttcaccgcat agcatatcac
      541 aaagatagtg aacagattgg gtatatagtc ggctattcca ttcaagatga cctttatagg
      601 attccaaatg taggagaata atgtataagc caagctcttg gtctgaggga aaatggagaa
      661 taataacgga accgtcagca gcaactgcaa cagcatgact acataacgca ccaggttggc
      721 aacaaacacc agcaggttga cctgcttctg cgtatccagc aattcataat cctgaataga
      781 gatcggtttc agcttggtat ccttcagctt ctgaatgcgt agtttgagtt ttctgaacag
      841 ccagttggta aacttgaaca agaagaactg tcccacaagc accaggataa agtacaagat
      901 acgcttaccc aactgccaca agctatgctc cttctgcatg gctttcagtt tgtccaccac
      961 gacatgcctc ttgctggcgg ccagctggtc gcgggtacag ttttcccaca aagcatcctg
     1021 atcggtaaag gaaatgatga ccttttcgcc atacatcaag tccgtaacaa tatccgtact
     1081 ctctaaataa acagagtccg gacgcagatt gaaacgcgtg cccaatgctt cgatgacgtt
     1141 gcttacatct ttggctcgct gttggggcgt atgccctcca cgcttggcat acagatagaa
     1201 caaagtgtcc ttctccacca ccaccggaat acccggtgtc accgtccgca acgaatcaat
     1261 gcgttgtttc tgcaatgcca gcttcaccga atcggccgca tagcccgcca acttcatctg
     1321 ctccatttcc atccgcaggt tcgcctcatt cagccgggct gtttccaact cctgccggac
     1381 aagcgacaac tgaatcgaat cggagtcagt ccttgccact gtgacactcc ccacactatc
     1441 ctcacctaaa acactgagca ctttatctac caactgagct gacactccgt ctgccagcat
     1501 caacagccaa caaagacaga aagcacggat aaccttcata tataaacttc ttgatttgat
     1561 tctttaatta tgcaaatata cccaataaat gcttcaaaca tacggaatgt ttttaacttc
     1621 ctatcctaat caacataact ttttcatgca aacatgaaag ttctgtatcc ggtttgcatt
     1681 atctttgtac tcaaaattga catacctatg gatatattgt ttcttgtcgg aggactgctc
     1741 ctcattcttc tgggtgccaa tggcttgaca gacggtgccg catccgttgc caaacgtttc
     1801 catataccgt ccatcgtcat cgggcttacc attgtcgcct tcggtacttc cgcaccggaa
     1861 ctcaccgtca gcatatcctc tgccctaaaa ggcagtgcag acattgccat cggcaatgtg
     1921 gtgggaagca atacgttcaa taccctgatg attgtgggtt gtacggccct ttttgccccg
     1981 atagccatta cccgtaacac actgaaacgc gaaatacccc tttgcatcct ttcatccttc
     2041 gccctgctga tttgtgccaa cgacgtctta ctggacagca gtggggagaa catactcagc
     2101 atcaccgacg gcctattgct gctatgcttc tttaccattt ttctgagtta tacttttgcc
     2161 attgcaaaaa gggatggaag tatgaaggaa ccggaaaaga agcacttaca ggaagaagac
     2221 gaaatcaggc tgttacccgc gtggaaatcc gccctataca ttctcggcgg acttgccggc
     2281 ctcatcatcg gaggtaattt ctttgtagac ggtgccagcg gcatagcccg cggattgggt
     2341 gtcagcgaat ccatcatcgg tctcacgctc gtagcaggcg gcacttcatt acccgaactc
     2401 gccacctcca tcgtagccgc cttgaagaaa aaccccgaaa tagccatcgg aaacgtcatc
     2461 ggaagtaatc tcttcaatat attcttcgta ctgggttgtt cggcctccat cactccactg
     2521 cgtctgacgg gcatcaccaa tttcgatttg tgggtactcg tagggtccag catcctgctt
     2581 tggctgttcg gtatcttttt cgggaaacgc atcatcaccc gggtggaagg aagcattctg
     2641 attctctgct acattgccta cacagcggta ctgatataca acctctaaca gcaaatttac
     2701 aaacacccta cgcggtattt taaagattat cacgtatttt taaataaggc aagctgtacc
     2761 tcggcataaa aaataagcaa gcttattttg ttctgctctc agtttgcatt acctttgtgg
     2821 tctcaatatt gaacaactat ggcaattaca atcaagaaag taaccacaag acgggaactg
     2881 gagcgcttta tccgtttcaa ctacctgcta tacaaaaaca acccttattc cgtccccgac
     2941 cttttcgatg acatgctcaa caccttcaac aagaagaaaa acgctgcatt cgaattttgt
     3001 gaagccgact atttcctggc ttatcgggaa ggtaaaatcg taggacgtgt agctgccatc
     3061 atcaaccaca aggcaaacca aacctggaac aaaaaggaag tccgcttcgg ctggatagac
     3121 ttcatcgatg atgcggaagt ctccgatgcc ctgattcgca ccgtggaaga atggggaaaa
     3181 gaacggggaa tgacacatat acaaggcccg ctgggattca cagatttcga tgccgaaggt
     3241 atgctcatcg aaggattcga ccagctcagc accatggcca ccatttataa ctatccctac
     3301 tatccgcaac atctggaacg catgggcttt gagaaggatg ccgattgggt ggagtacaaa
     3361 atctacattc ccgacgccat acccgacaag cacaagcgca tctccgacct catccagcgc
     3421 aagtataacc tcaaggtaaa gaaatacaca tctgccaaga agattgccca agactacggt
     3481 caggccatct tcgaactgat gaacgaagcc tatcagccac tctatggcta ttctgcactg
     3541 agccaacggc agattgacca atacgtcaag atgtacctgc ccatcctcga cctacgcatg
     3601 gtgacattga ttaccgatgc cgatgaccag ctgcttgccg taggcatttc catgccgtca
     3661 ctcgccgaag cgttgcaaaa agcccacggg cgcctgcttc ctatgggttg gtatcacctg
     3721 gccaagacca tcttcttgaa gaaatatccc aagatgctcg atttgctgct ggttgccgtg
     3781 aaaccggagt atcagaacaa gggggtaaat gcattgttgt tctccgacct tatccccgtc
     3841 tatcagcaac ttggtttcga gtatgccgag agtaatccgg agctggagct gaacggcaag
     3901 gtgcaagcgc agtgggagta cttcaagacg gaacagcata aacggagaag atgctttgtg
     3961 aaaggaataa aataagttct aaatccagaa tataagcttg tcagaagtcc ataaaagaca
     4021 ttattttttt gcgaaccccc gaatttctca ttacctttgt cgcaatgcgc aatatgaagg
     4081 aataacgtac ttatggaaga taacaacaat atgaccctgc cgctggaaga agcagacaac
     4141 aatatcacag agagccccgt ttccagcgtg gaatataccg acgacaacat ccgccacctg
     4201 gacgacatgg agcatatccg tgtccgttcc ggtatgtaca taggccgtct gggcgacggc
     4261 tcacagaacg atgacggcat ctatgtgttg ctgaaagaag tgatggacaa cagcatcgac
     4321 gagttcaaga tgggtgccgg aaagcgtata gaagtgacta tagaagacag tctgcgtgtc
     4381 agcgtacgcg actatggacg aggcattccg caaggcaaac tggtagaggc ggtcagcaaa
     4441 ctgaataccg ggggtaaata tgactcgaag gctttcaaga aaagtgtcgg actgaacggc
     4501 gtaggtatca aggcagtcaa tgcgctgagc agccgcttcg aagtacgcag ctaccgcgac
     4561 ggcaaggtac gtatcgccat ctttgaaaaa ggaacgctgt tgagtgatgt gaccgaagac
     4621 tcgacagaag aaagcggaac ctatatcttc ttcgaaccgg acgccacact cttcttgaac
     4681 tattccttcc agaaccagtt cgtagaaacc ctgctgcgca actacaccta cctgaatacg
     4741 ggcctcacct tcatttacaa cggccagcgc atcgtttccc gccacgggct ggaggacttg
     4801 ctgaaagaca acatgaccag cgaaggcctt tacgacatca tccacctgaa aggagaggac
     4861 atcgagattg ccttcacaca caccaaccaa tacggcgaag agtactactc ctttgtcaac
     4921 gggcaacaca ccacccaagg cggcacacac cagactgcct tgaaggaaca cattgcccgt
     4981 accatcaagg agttctacaa caagaaccag gaatatgccg acatccgcaa cggactggta
     5041 gccgccattg ccatcgacgt ggaggaaccc atgttcgaga gccagaccaa aacgaaactg
     5101 ggcagcaaca acatgtggcc tgccgcgccg caggaacaca agcccgccgg ccccacggtg
     5161 aacaaatacg taggagactt catcaagacg gaagtggaca actacctcca caagaacccg
     5221 cttgtggccg aagtgatgct gcaaaagata caagactccg agaaagagcg caaagccatt
     5281 gccggcgtca ccaagctggc acgcgaacgc gccaagaaag ccaacctgca caaccgcaag
     5341 ctgcgcgact gccgctacca cttgagtgac ggtaaaggca aagaccagga aaccgaatcc
     5401 tgcatcttca ttaccgaggg agactccgcc agcggttcca tcaccaagag ccgcgacgtg
     5461 aatacccaag cagtattcag cctgcgtggt aaaccgctaa attcctacgg actcaccaag
     5521 aaagtagttt atgaaaacga agaattcaac ttgcttcaag cagccttgaa tatagaagac
     5581 ggcatagaga cactgcgcta caacaaagtc atcgtagcta ccgatgccga tgtggacggc
     5641 atgcacatcc gcctgctcat catcaccttc ttcctgcagt tcttccccga cctgataaag
     5701 aaaggcatgt atatatcctg caaacccctc tcttccgcgt gcgcaacaaa aagaagacaa
     5761 gttattgcta tacagaggag gaacgtgtga aagccattga agaactgggt cccaaccccg
     5821 aaatcacccg attcaaaggt ctgggagaaa tctcgcccga cgagttcaag cattttatcg
     5881 gcaaggatat gcgtctggaa caagtgtccc tgcgcaagac agacctcgta aaagagctgc
     5941 tggaattcta catgggtaag aataccatgg aacgacaaaa ctttattatc aacaacttgg
     6001 ttatagaaga agatttggca tcatgagaag agctatcttt ccgggaacat tcgacccgtt
     6061 tactatcgga cactcttcgg tagtgagccg tgcactgact tttatagacg aaatcgtcat
     6121 aggcatcggc atcaatgaaa ataagaatac gtatttcccc ttggaaaagc gcgaacaaat
     6181 gatacgagac tactaccgga acgagccgcg catcattgtg cagtcctatg actgcctgac
     6241 tatcgacttt gcccggcagg tagatgccag tctgataata cgcggcatac gcaccgtgaa
     6301 ggatttcgaa tacgaggaaa ccattgccga catcaaccgc aaactgaccg gcatagaaac
     6361 catcctgctc ttcaccgagc cggaacttac ctgcgtcagt tccaccaccg tgcgcgaact
     6421 gctgcaatac ggcaaggaca taagcatgtt cataccggag ggaatggaga ttagggatta
     6481 aggataaagg attagggatt aaggataaag gattagggat taaaatggaa atgatgaaaa
     6541 aactatttac tattataata tgtatatgcg cggtgacggc acaagcgcaa aagccgaaca
     6601 atgaagccct gcgcaaactg caaatggcag agtttgccat caccaacctt tatgtggaca
     6661 aggtggatga agacaagctg gtggaagaag ccatcatcaa gatgctggca caactcgacc
     6721 cgcactccac ctacaacaac gccgaagaag tgaagaagat gaacgagccg ttgcaaggca
     6781 atttcgaggg catcggcgta cagtttcaga tgatagaaga taccctgctt gtgatacaac
     6841 ccgtgagcaa cggaccttcc gagaaggtgg gcatccttgc cggcgaccgt atcgtagccg
     6901 tcaatgacag cgccattgcc ggagtaaaaa tgagcacgga agatattatg agccgcctgc
     6961 gcggaccgaa agactcggaa gtgaaactca ccatcgtgcg ccgtggcgtg gacgaccagc
     7021 tgtacttcac cgtgaagcgt gacaaaattc ccatcctcag cctggacgca tcttacatga
     7081 tacaacccaa aaccggctat atccgtatca accgcttcgg ggcaaccacc gccgaagagt
     7141 ttgcagaagc cctgaaaagc ctgcaaaaga aaggaatgaa agacctcatc ctcgacctgc
     7201 aaggaaatgg aggagggtat ctgaatgccg ccatcgacct tgccaacgaa tttctgaagc
     7261 aaaaagaact catcgtctac accgaaggaa gggccgcacg ccgcagtgat ttctttgcca
     7321 aaggtacggg caacttcaag aacggccgtc tcatcatatt ggtggacgag tactccgctt
     7381 ctgccagtga aatcgtgacc ggagccatcc aggactggga cagaggcgtg gtagtaggac
     7441 gccgcacctt cggcaaggga ttagtacagc gtcctatcga cctgccggac ggttccatga
     7501 ttcgcctcac tatcgcccgc tactatactc cttcgggccg ttgtatccag aagccttacg
     7561 acagcaccgc caacctcgac ggccgcctaa ccggcgagaa cagtcaggat aagtataacc
     7621 aggaactgat agaccgcttc aatcatggag aaatgattca tgcggacagt atccattttg
     7681 ccgactccct gaaagcacag accaagcgta tgggacgtac cgtttacgga ggtggaggta
     7741 tcatgcccga cttcttcgtc cccatcgaca ctacccagta cacagactat caccgcaacc
     7801 tcgtagccaa aggcgtggtt atcaaagcca ctaccggcta catcgagaag caccggaagg
     7861 agttgcagaa caaatacaag aaattcgaag ccttcaacga gaagttcgag atagacgata
     7921 acttccttgc cgaaatacgt acgcttgccg acaaagagaa aatcaagttt gacgagaaac
     7981 agtacaacca atccctaccg ctcatcaaga cacaacttaa agccttgata gcccgtgacc
     8041 tatgggacat gaacgaatac ttccaggtga tgaacagcac gaaccagagc gtgcagcaag
     8101 ctctaaaagt gttgaacgaa ggcatctaca gcactattat ccaatagccg acttgaaaca
     8161 aacttaggcg cggattatgc ggatttagtt tatctaactc cgcgtattcc gcgtaattcg
     8221 cgcctaaaat cattctccga acagccactt attcagccac ttgttgacgt agatgttgac
     8281 cacagcacat ccagcaccga ttgcagcccc cgccaacaca tccgacggat aatgcactcc
     8341 ctcgttcata cgggaaactc ccacggaaca agcccacagg cagacggagc tatcacatac
     8401 catttaggat actttacact gagcgaggtg gcaagggcaa aagccgtcgc cgtatgtccg
     8461 gaaggaaaag acgggctgcc ttcatggcta tatgcatgca ctctgtcggg atatttatca
     8521 taaggacgct cacggtccac cagatatttc attccataag tcacaacaaa agcccccgct
     8581 acacttgtac ctacgtagac cgcatctttc agcaaaccct tatcatgttt tatccaagcg
     8641 gcaaccgcca tcgccaccgg aacaccgaca gcaacatagg gctccgaacg tgaaattatc
     8701 ttattatagt tacggacaaa cttgccatcc caactgttaa cccggtgcaa agtgttaata
     8761 tcccaattct gtgccgaaag accggataca acaaggcaga taaaatatac aaaaaaaata
     8821 gcctttttca taagtccttt atattagttt gacgcaaaga taggacaaat agatagagtt
     8881 ttcacaaaaa aattctatct ttgttgccac atttataata attcgctaat catttcatga
     8941 gactggaaac ttgctgcaac cgacagattg attgtatggt atgtccccaa aaatcagaag
     9001 gagtattggt ttaccgccac taccccaagg gacaacattt ctctgctgaa aagtgcacac
     9061 agaactgcat gatatttatg ctgaaaggtg aattacttgt aaacagtgac gaatatccgg
     9121 gcaccactct ccaaagccgc cagctcatct tgcaagccat cggctccaaa gtagaactcc
     9181 tggctttgac cgaagtggaa tatattgtct attggttcac cgagcttcct ctgatttgcg
     9241 aagagcgcta caaggagata ctgaaacgct cggaagcccc cttgacttat accccgctta
     9301 gcgcgatttc catgctcgaa ggctcctgaa aagccttgcc tgctacctca acgagcaacc
     9361 ctatgcgtgc agcaaataca ttgaaatgaa atgccaggaa ttggtataca tattgacatg
     9421 ctactatccg ctacaccaaa tcagtacatt cttctacccc atcagcactt atacggaaag
     9481 cttccaatat ttcgtcatgc agaactacga caaggtgaag aatgtggaag agtttgccca
     9541 cctcggtgga tataccacca ccacattccg ccgtctgttt aaaaatatgt atggggtccc
     9601 ggtctatgaa tggattctgg acaagaaacg tgaaggaatt ctgaacgacc tgcaatacac
     9661 caaacaacgc atttcagtca tcagcgcccg ctatggcttt gattccctat cccactttgc
     9721 ccacttctgc aaagactctt tcggagacac gccccgcgcc ctgagaaaac gttcagcaaa
     9781 cggagaaaag atttccatta tctgcaaaga gcaaggcaaa gaccaggagg acgagtaaac
     9841 cttttacttg tccgtaaact tcgcattctg ccggattacg gaattatttc tttaatcgct
     9901 tgctttatcg ctggatttct cctatttttg cgaaacattt acagaagtat cctgatagaa
     9961 caaattttca aactattaaa taacttaaat tcaatcattt atgtggttaa gtaattcatc
    10021 tgtaggaagg aaagtggtga tgagcgttac cggtatcgcc cttgtcctgt ttctgacatt
    10081 tcacatggcg atgaacctgg ttgcattagt ctcggctaat ggctacaaca tggtttgtga
    10141 gttcctggga gcaaactggt acgcattggt ggctacggta ggtctggctg ccttattcat
    10201 catccacatc atctacgctt tctggctgac tatgcagaac cgtaaggcac gtggtagcga
    10261 acgttatgcc gttacggaaa agcccaagac tgtggaatgg gcttctcaga acatgctcgt
    10321 actgggtatc atcgtaatcg tgggtttggg cctgcacctg gtaaacttct gggctaaaat
    10381 gcagcttccc gagttgatgc acaacatggg catgcatgcc gacaccctca cgctggcata
    10441 tgcagccaac ggtgtctatc acattcaaaa caccttcagc aatccggtat tcgtagtgct
    10501 ttacctcgtt tggctgggcg cattgtggtt ccacctcact cacggtttct ggagctccat
    10561 gcagtctttg ggctggaaca acaaagtatg gattaaccgt tggaaatgta tctccaacat
    10621 ctattctact atcgttgtcc tctgcttcgc tctggtagtt gtcgtattct ttgcaaaatc
    10681 attgtgcggc gcttgctaaa ttcaaattgt aaatgactaa attgtaaatt gcattatgac
    10741 taagatagat tctaaaatac cggaaggacc ggtggctgag aaatggacca attataaagc
    10801 tcaccaaaaa ttagtgaacc ctgccaacaa gcgtcgtctg gacatcatcg tagtaggaac
    10861 cggacttgcc ggtgccagtg ctgccgcctc tctgggcgaa atgggtttca gagtattcaa
    10921 cttctgcatc caggactctc cgcgccgtgc acactccatc gctgcacaag gtggtatcaa
    10981 tgctgctaag aattaccaaa acgacggtga ctctgtatac cgtctgttct acgatacagt
    11041 aaagggtggc gactaccgtg cccgcgaagc taacgtttac cgtctggctg aagtatccaa
    11101 caatattatc gaccaatgcg ttgcacaagg tgttcctttc gcccgcgaat acggcggtac
    11161 actggacaac cgttctttcg gtggtgctca ggtatcccgt actttctatg ccaagggtca
    11221 gaccggacag cagctgttgc tgggtgcata ctctgcattg agccgccagg tgaacgtagg
    11281 cactgtgaaa ctgtataccc gctacgaaat ggaagacgtt gtcctcattg acggacgtgc
    11341 ccgcggtatc attgcaaaga acctcgttac cggtaaattg gaacgttttg ccgcccacgc
    11401 tgtggtaatc gctaccggtg gttacggcaa tgcctacttc ctttctacca atgcaatggc
    11461 atgtaactgc tctgcagcaa tggcttgcta ccgtaaaggt gcctggtttg ccaaccctgc
    11521 ttacgtacag attcacccca cttgtatccc ggttcacggc gacaagcagt ctaagctgac
    11581 tttgatgtcc gaatctctgc gtaacgatgg tcgtatctgg gttccgaaga agctggaaga
    11641 tgccaagaaa ctgcaggaag gtacactgca aggaaaagat attcccgagg aagaccgcga
    11701 ctactacctg gaacgccgtt atccggcatt cggtaacctc gttccgcgtg acgttgccag
    11761 ccgcgctgcc aaagaacgct gcgacaaggg cttcggcgtg aacaacaccg gtcttgccgt
    11821 attccttgac ttctccgaag ctatcaaccg tctgggtaaa gatgtcgttg cacaacgtta
    11881 cggcaacctc ttcgatatgt atgaagaaat cactgatgtc agcccatacg aaaacccgat
    11941 gatgatttat ccggctatcc actataccat gggtggtatc tgggttgact acgaactgat
    12001 gacctccatc aagggactgt tcgccatcgg tgaatgtaac ttctccgacc acggtgcaaa
    12061 ccgcctcggt gcttccgccc tgatgcaagg tctggccgat ggttacttcg tattgcctta
    12121 cactatccag aactatctgg ccgaccagat tacagttccc cgtttctcta ccgacctgcc
    12181 cgaatttgca gctgcagaaa aggccgttca ggagaagatt gactggatga tgaacatcaa
    12241 gggtaagaag tctgtagact ctatccacaa ggaactgggc cacattatgt gggaatatgt
    12301 aggtatggga cgtacggccg aaggcttgaa ggaaggtctg aagaagctga aagaagtccg
    12361 caaggagttc gagaaagaac tgttcatccc gggtgacaag gaaggtatga atgtagaact
    12421 cgacaaggct atccgtctgt acgacttcat cactatgggc gagctggttg cttacgatgc
    12481 actgaaccgt aacgaaagct gcggcggtca cttccgtgaa gaatatcaga ctgaagaagg
    12541 cgaagccaag cgtgacgatg aaaactactt ctacgtggct tgctgggaat atcagggttc
    12601 tgacgaaaag gaaccggtat tgctgaaaga gccgctggtt tacgaagcaa tcaaggtaca
    12661 gactcgtaac tacaagagct aatcgggaag ttgaacattt aaagaattaa agaaaatgga
    12721 taaaaatata tcatttacgc tcaaggtatg gcgccagaag ggtccgaaag caaaaggcgc
    12781 ttttgaaaca taccaaatga aagatatccc gggcgatact tcattcctcg aaatgctgga
    12841 tatcttgaac gaacagctga tttctgaagg taaagaaccg gttgtattcg accacgactg
    12901 ccgcgaaggt atctgcggta tgtgttcgct ctacatcaac ggacatcccc acggtcctgc
    12961 aaccggcgct acgacttgcc agatttatat gcgtcgtttc aacgacggcg ataccatcac
    13021 tgttgaaccg tggcgctctg ccggtttccc ggttatcaag gacttgatgg tcgaccgtac
    13081 ggcctacgac aagattatgc aggcaggcgg ctacgtcagc gtacgtaccg gtgctcccca
    13141 ggatgccaac gctatcctga ttccgaagcc catcgctgac gaggctatgg atgctgccag
    13201 ctgtatcggt tgtggtgctt gtgtggctgc ttgtaagaac ggttctgcta tgctgttcgt
    13261 ttctgccaag gtgagccagc tgaacctgtt gccccaaggc aaaccggaag cattgcgccg
    13321 tgccaaggct atgttgagca agatggacga actcggtttc ggtaactgta caaacactcg
    13381 tgcgtgcgaa gctgaatgcc cgaagaatgt ttccatcagc aacattgctc gcctgaaccg
    13441 cgactttatc attgcgaaac tgaaagacta atccggtctt tctgcaaata atataggatg
    13501 cgcttcggat aaaccttttg agcaagctca gatttatcac tcagctttca ctatatttga
    13561 ttaatatcac aagagactcc tctgccggga aaccgccgga ggagtttttt tatgacatgc
    13621 cgtttacttc agataaattg ccggcacgca agctacgggg agaagccccg aaattctttt
    13681 tgcagaaatt ggaaaaatga ggcagcgatt caaagccata tttatagcaa atctctgata
    13741 tagaagcatc cgtataacga agttcataaa ccacgctttc cttcctccgt tccatcatcc
    13801 actcgtacac cggttgatga aaaacagaat tgaatatacg ccggaaagta gctactgtat
    13861 atcctcccaa ctgggcaagt tcctctaccg tcttgacttt ggcatgattc tgcaagacaa
    13921 agtagtggaa ggaattagta tactgggcaa gaggatgtat cagcatggaa agctcatagt
    13981 cggagtagat cctcccaact gggcaagttc ctctaccgtc ttgactttgg catgattctg
    14041 caagacaaag tagtggaagg aattagtata ctgggcaaga ggatgtatca gcatgga
//
