LOCUS       gnlProkkaPGJDPBJI_90   13785 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PGJDPBJI_90.
ACCESSION   gnlProkkaPGJDPBJI_90
VERSION     gnlProkkaPGJDPBJI_90
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 14:16:04
            Original ID  :: gnl|Prokka|PGJDPBJI_90
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 163941
            Orig. end    :: 177726
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13785
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10351]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10351
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..13785
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13785
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             2109..3143
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg87_125"
                     /sec_met_domain="PF04055 (E-value: 1.9e-17, bitscore: 57.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKYPLLGMTLVELQSLTKRLGMPGFAAKQIASWLYEKKVASIDD
                     MTNLSLKHRELLKQNYEVGAEAPVDEMRSVDGTVKYLYKVGENHFVESVYIPDDDRATL
                     CVSSQVGCKMNCKFCMTGKQGYTANLTASQIINQIHSLPERDKLTNVVMMGMGEPLDNL
                     DEVLKALELLTATYGYAWSPKRITLSTVGLRKGLQRFIEENDCHLAISLHSPLTVQRAE
                     LMPAEKAFSITEMVELLKNYDFSKQRRLSFEYIVFKGLNDSQVYAKELLKLLRGLDCRV
                     NLIRFHAIPGVDLEGADMDTMTRFRDYLTSHGLFTTIRSSRGEDIFAACGMLSTAKQEK
                     NNES"
     CDS             3162..4202
                     /locus_tag="ctg87_126"
                     /transl_table=11
                     /translation="MKKYSFILCIALVAFVVASCGLKGNHTSSGRAYELLVVVDHGVWD
                     RAAGRALHDALDADMPGLPQSEPSFRIMYTSPKDYDSTLKLIRNIIIVDIQDIYTKASF
                     KYAKDVYANPQMILTIQAPNEEEFEKFVEENKKTIVDFFTRAEMNRQITFLEGKHSNFI
                     SQKVDSLFGCDIWVDAELANSKTGDDFFWASTNTGTADRNFVMYSYPYTDKDTFTKEYF
                     VHKRDSVMKANIPGFKEGVYMSTDSLLTDVRPINVQNSYTMEARGLWRMKGDFMGGPYV
                     SHTRLDEKNQRIITAEIFVYSPDKMKRNLVRQMEASLYTLKLPNEVQQKQIPLGEASKE
                     AEQTNK"
     CDS             4207..5301
                     /locus_tag="ctg87_127"
                     /transl_table=11
                     /translation="MEDNKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPK
                     VAAYHRKALDIQANFSIVNSATEAGYNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     RAIEEYREGLIDVIVTAPINKHTIQSEEFSFPGHTEYIEERLGNGDKSLMILMKNDFRV
                     ALVTTHIPVREIATTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLG
                     MEEQEVIIPAMKEMEEKGILCYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAM
                     EDGVNYTAGLPVVRTSPAHGTAYDIAGKGLACEDSFRQAIYVAIDVFRNRQREKVARAN
                     PLRKQYYEKRDDSDKLKLDTVDED"
     CDS             5311..6552
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 385.8; E-value:
                     4.8e-117)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg87_128"
                     /transl_table=11
                     /translation="MTRAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMPTQARLLRVLESGEFIKVGSSKVQKTDVRIVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQVGTVVTTPVVTTHQPSVPA
                     IIHTMQPAVCKDDDDIQDTEEYVEEPPLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             6539..7066
                     /locus_tag="ctg87_129"
                     /transl_table=11
                     /translation="MNWIKKIIRPLLLFGLPLVVIACTVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPSQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSTQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             7072..7845
                     /locus_tag="ctg87_130"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGIPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSYLLEETPATEQPAEETPKLKGFELIDDFIEK
                     SESDSPLCMKPLREEMPSSPTSSDELTEEETMKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             7852..8268
                     /locus_tag="ctg87_131"
                     /transl_table=11
                     /translation="MYLLFVILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSIATAYVVPRSAVAKDAVLEQAQKEQQTNPYNLPAGTAAP
                     QTEAPATNAPATETPAPATETPAPATETPAPAAE"
     CDS             8515..9903
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 95.3; E-value: 4.9e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg87_132"
                     /transl_table=11
                     /translation="MTEHLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AISTTFPEGAMLFGFKTQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGYTDEGGAFHTNIPAPILFCLIMLCVGTIAFFLYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMVIGSLMLIFVHTMFAL
                     PILNIWWFATIIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMTIFALFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             10001..10351
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg87_133"
                     /sec_met_domain="PqqD_RRE (E-value: 2.5e-11, bitscore:
                     36.3, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.1e-17, bitscore: 56.3,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAKEKINLLEVIPCRSEHITAEREGETIVLSFPRFKYPWMQRFL
                     VPKGMSKELHVKLEEHGTAVWELIDGKRNVSEIIEKLADHFQNEEGYESRVSAYLSQMQ
                     KDGFIKLVIPVA"
     CDS             complement(10534..10818)
                     /locus_tag="ctg87_134"
                     /transl_table=11
                     /translation="MVGEGHAFDMIRRIKEGREASRLRRERANDKLKHLNRANEPYPLP
                     NTTPEEMERIIHDSEKKKEKDSNYFVWGTLIIMGVLIAIAVILWAVFIK"
     CDS             complement(10855..11922)
                     /locus_tag="ctg87_135"
                     /transl_table=11
                     /translation="MKKLIIAAGLLMTTSAYAQTEVLTGVTRGKDYGVVYSLPKTQIEL
                     EIKANKVNYTPGEFSKYADRYLRLTNVSADPEEYWELTSVKVKSVGVPNSETTYFVKLK
                     DKTVAPLMELTEDGIVKTINVPYSNSSVGKKAAPAPTVLQKKANPREFLTEEILMASST
                     AKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEEAMTQMFSGTCN
                     KEERTFTVRLTPDKEFNNEVAFRFSKKLGVVANNDLAGTPFYISLKDLKSVKIPQEDGK
                     KKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLFNKNSTIKVYFD
                     PNTGGLLKVDREEGK"
     CDS             complement(11995..13506)
                     /locus_tag="ctg87_136"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIENEPIASIDLMERAATVLTKAITDRWNT
                     ETPVTIFAGPGNNGGDALAVARMMAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEV
                     KFHEISTQFVPPVLTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPAMVVAIDIPSG
                     LMGEENTFNVKANIIRADVTFSLQLPKLAFLFAENTEFVGEWEVLDIQLSEDGIEEMET
                     NYEMLEIEEIRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPMCNNDILQTSIPEAIVETDINETCFTVPTDTDDYQAVGIGPGLGRNEETEAALLEQ
                     LEHCQTPVVVDADALNILANHRHALTHLPKGSILTPHPKELERLTGKCQDSYERLMKAC
                     ELARAAHVHIILKGAYSAIITPEGKCFFNPTGNPGMATGGSGDVLTGVILALLAQGYPT
                     KEAAKIGTYIHGLAGDVAQKKQGMIGMIASDIITCLPTAWRLVSE"
ORIGIN
        1 tggtttttca caggcggatg ccaagtcgtt ctcaaagcaa tatttgtcta cttactccaa
       61 ggctttgtct gcacaacagg aagatattct tgcttcgtgg gtgctggcta aacaaccgcg
      121 ctgtttaagt gtattgctca acgagctggt ttcgttcggt cagtacgatg ctctcaatga
      181 atatatgagt ggatattgcc ggctcaatga ggttgggcaa ttctatgaca gtgtgctacg
      241 gcgtttgtcg gctgattatg gtttcgaaga gattggaaga acgcttctga tgctttcact
      301 tactttagaa ggatttaccg aagatgaagt gaagagcatg gcagacatta atcagatact
      361 ttggtcgcag ttgagagtgg aaatgagcag ctggcttacc aacaaaggag gacgatattg
      421 cattggtgac acacaaatgg tagaggcaat cgaacgctat ttcgctcaag atgacgaatg
      481 tatagatgat agtcgccatg aaattatttc cgctttgctg gatgaggaag aggtcctttc
      541 ccatccgttg acttttgccg attataacta tcgcatgaaa cagttctgct accatgattc
      601 gtatcgctat aaagtggaga ttacctatca atgctataag atgcaagaat gggatatatt
      661 gaaggattgg atttgtgatg tggagatttt cgagattttg tatcgcacga atcgttctct
      721 gttggaagat agctggaagg cgatcatgaa cgacaatcct gaagttacgc ctgaagtcta
      781 tgccgaattg gactttgatg agatcgattc ttttttaatt cctgtcattg ctaatgatat
      841 ggctactttc ttgagcagtt ctttccatct gacgaaggcg gcagctgctg tgagtgagaa
      901 gagtatggaa ggtgctgcca tgccactcat tgccaagtcg gtattgaaga tgaatgaggg
      961 atgccgctat gcccgtaatg aagagtacga aacggcatgc gactgtttct tgaaagcatt
     1021 ggtgatgcag gaaaacattg tacctactcc ggaactggag attgccaaca cctgccgaaa
     1081 tctagctctg gcatattact acaatgagca atacaatgaa gcagtgatct atctgaatag
     1141 ggcgcttgat tatcatgcgg cttctgctga cgagaagagt caggcagaag tcattgaact
     1201 ttccgaatat ctggcttatt gtgattacta taaggatgag gaagagagtg ctgccgagaa
     1261 attccggaaa gtagctgaaa tgcatgagtc gttgaatggc agactgtccg gtggagtggc
     1321 taaatgtttg cgtatgcagg gtaaatgtct ttattatatc aaacgatacg atgaagcatg
     1381 gatgctgatg aatcaggcgt tggacattgc tatacagata gatagtaaaa aacagatcgt
     1441 cgcttgtcat aaacagttgt attatctgtg cagggaattc aaacggatga tgaatgaacg
     1501 tggcgatgag caggcatcta ctttattctt ccgtgagtct cttctgcatg aaatgtattt
     1561 cagcgaaaaa ccgcgtctgg cggaactgac tgtccgctac gaggcattga gatgtgatat
     1621 tatgcagcag tattacatga ataaagacta tgataacgtg attcgtattg caacgtcttt
     1681 ggattttcac gatgatactg accctaatgc ttcctgtctg gtatattatt acaaagcaca
     1741 ggcttatgtg aagttggaga attatccaat ggcgaaagag gctttcttca gagagttcga
     1801 actgcgaaag aagtatttgg gatgggagga agaagatacg attctggctt gtcagaactt
     1861 aggggttttg cacagctttt gtaatgaacg ggaagaggcg ctggcttgtt tccgtgaggc
     1921 gtacggtcat gaagtgaaaa agaatggcga ggattctgaa atggcgcaaa agctacttca
     1981 atatatcagc gtggttgaat cataacggag gcatacttcc cttttttgtt aacttttaca
     2041 ttcctgctat acggaaatcg actttatttc cttacatttg cagatataaa ctatcaacag
     2101 aaagaagaat gtctaaatat ccccttttag gaatgactct tgtagagctt caatcattga
     2161 caaaaagact gggtatgccc ggctttgctg ccaagcagat tgcatcctgg ctttacgaaa
     2221 agaaggtagc ctcgattgat gatatgacta atttgtcatt gaaacaccgg gagttgctca
     2281 agcagaacta tgaggtggga gcggaagctc cggtagatga aatgcgctct gtagatggta
     2341 cggtgaagta tctttataaa gtgggtgaga accattttgt agagtcggtt tatataccgg
     2401 atgatgaccg ggcaacgttg tgcgtgtcgt cacaagtagg ttgcaagatg aactgtaagt
     2461 tctgtatgac cggtaaacag gggtatacgg ctaacctgac cgccagccag atcataaacc
     2521 agattcattc gctgccggaa cgggacaaac tgactaatgt cgtaatgatg ggaatgggcg
     2581 agccgctcga taacctggat gaggtattga aggcattgga actactgacc gctacctacg
     2641 gttacgcatg gagtccgaag cgtatcacgc tttctacagt cgggctacgg aaaggattgc
     2701 agcgttttat tgaagaaaat gactgccacc ttgccatcag ccttcactct ccgctgaccg
     2761 ttcagcgtgc tgaattaatg ccggcggaaa aggcgttttc aatcaccgaa atggtggaac
     2821 tgttaaaaaa ctatgatttt agtaaacaac gtcgactttc gtttgaatat attgttttta
     2881 aagggctcaa tgattcgcag gtctatgcca aagagttgct gaaacttctt cgcgggctgg
     2941 attgcagggt gaatctgatt cgttttcatg ccataccggg ggtagacctc gagggggcgg
     3001 atatggatac gatgacccgt tttcgtgatt atctgacgtc acacggactt ttcaccacta
     3061 tccgttcatc caggggcgaa gatatttttg ccgcttgcgg tatgctgtcg acagcgaaac
     3121 aggagaaaaa taatgaaagt taatatataa aaccgaacat catgaaaaag tactctttta
     3181 ttttatgcat cgctttggta gcctttgtcg ttgcatcttg tggtctgaaa ggaaatcaca
     3241 cctctagtgg tcgtgcttac gagcttttgg ttgtagtaga tcacggtgtt tgggatcgtg
     3301 ctgccggaag ggctttacat gatgcgctcg atgctgatat gcccggtttg ccgcagtcgg
     3361 aaccttcttt ccggattatg tatacttcgc cgaaagatta tgattctacg ctgaagttga
     3421 tacgtaacat tattattgta gatatacagg atatatatac gaaagcctcg ttcaaatatg
     3481 cgaaggacgt gtatgccaat ccgcagatga tattgactat ccaggctccg aacgaagaag
     3541 agttcgagaa gtttgtggaa gagaacaaaa agacgattgt cgacttcttt acccgtgcgg
     3601 aaatgaaccg tcagattacg tttctagaag ggaaacacag taatttcatt tcgcagaaag
     3661 tggacagttt gttcggatgc gacatctggg tggatgccga actggctaat tcaaagaccg
     3721 gggatgattt cttctgggct tctaccaaca caggtactgc cgaccgtaac tttgtgatgt
     3781 actcttatcc gtacactgac aaggatacgt ttaccaaaga atattttgtg cacaaacgtg
     3841 actccgtgat gaaagccaat attcccggat tcaaggaggg cgtttatatg tcgaccgata
     3901 gtttgctgac cgatgtccgt ccgatcaatg tgcagaacag ctacacaatg gaagcacgtg
     3961 gcctgtggcg tatgaagggc gactttatgg gtggtccgta tgtgtctcat actcgtctgg
     4021 acgagaaaaa ccaacgaatt attacagcag aaatatttgt ttattcacct gataaaatga
     4081 aacgcaacct ggtacgccag atggaagcat ctctgtatac actgaaactt ccgaatgaag
     4141 ttcagcagaa gcagattcca ttgggagaag catctaagga agcggaacaa actaataaat
     4201 aaaaacatgg aagataacaa gataaggata ggtatcaccc aaggagatat taacggggtg
     4261 ggctatgagg tgattcttaa gacattttcc gaccctacaa tgttggaact atgtactccg
     4321 atcatttatg gctcaccgaa agtagcggct tatcatcgca aagcgctgga tatacaggcc
     4381 aatttcagca ttgtcaactc tgctaccgaa gcggggtaca accgtttgag tgtggtgaac
     4441 tgtacggatg atgaggtgaa agtggaattt tccaaacccg accccgaagc cggtaaagct
     4501 gcgctggggg ctttggaacg tgccattgaa gaatatcgcg aagggttgat agacgttatc
     4561 gtaacagctc cgatcaacaa acatacgatt cagtcggaag agttctcttt ccccggacat
     4621 acggaatata tcgaagaacg tctgggcaat ggtgataagt cattgatgat tttgatgaag
     4681 aatgacttcc gggtggcttt ggtgacgaca catatccctg tcagagagat cgcgactacg
     4741 attaccaaag aactgattca ggagaaactg atgatattcc atcgttgcct gaaacaggat
     4801 ttcggtatcg gcgctccgcg tattgcggtg ctctctctca atcctcatgc cggagacggt
     4861 ggtttgttgg gaatggaaga gcaggaagtg attatccctg ccatgaaaga aatggaagag
     4921 aaaggaatcc tttgctacgg tccttatgcg gccgacggct ttatgggttc aggcaattat
     4981 actcattttg acggtatcct ggcgatgtat cacgatcagg ggctggctcc gttcaaggcc
     5041 ttggctatgg aagacggggt gaactatacg gcaggcctgc cggtagtacg tacttctccg
     5101 gctcatggaa cggcatacga tattgcaggc aagggattgg cttgtgaaga ttctttccgt
     5161 caggcaatct atgttgccat cgatgtgttc cgtaatcgtc agcgggaaaa agtggctcgt
     5221 gccaatccgt tgcgtaaaca gtattacgag aaacgtgacg atagtgataa actgaagctg
     5281 gatacagtag acgaagatta aaaacgagtg atgacgagag cagagataca acaagtgaaa
     5341 cagcgtttcg gtattattgg aaatactgaa gcattgtcgc gcgccataga tgttgccatt
     5401 caggtagctc ctaccgattt gtctgtgctg attaccggag aaagtggagt cggaaaagaa
     5461 agttttccgc agattattca tcaatatagc cggaggaagc atggacagta tattgctgtc
     5521 aactgtggtg ctattccgga gggcacgatt gattccgaac tgttcgggca tgagaagggt
     5581 gcgtttaccg gtgcgattgg cgaacggaaa gggtactttg gcgaagccga cggtggtact
     5641 attttccttg atgaagtagg ggagttgccg atgcctaccc aggcgcgttt gctccgtgtg
     5701 ttggagagtg gcgagtttat aaaagtaggt tcgtccaaag tgcaaaagac ggatgttcgt
     5761 attgtggcag ctaccaatgt caatctgaca caagcgattg cagaaggacg tttccgtgaa
     5821 gatttatatt accggttgaa tacggtacct atccaaatac cgcctttgcg tgaacgtggt
     5881 gacgatgtac ttttgttgtt ccgtaagttt tccgcagact ttgcagagaa ataccggatg
     5941 cctgctatcc agttgacgga ggatgcgaag aaagagttat tggcttaccc gtggcccggc
     6001 aacgttcgtc agttgaagaa catcaccgag caaatatcta tcattgaaac caacagggag
     6061 atctctgctg ctatcttgca gaattatctt cctgcacaaa atacgcaacg tcttcccgcg
     6121 ctgatgggaa cgcgtgagag taaaggcttt gagagcgaac gggagattct ttattctgtt
     6181 ctgttcgata tgcgccagga agtggcggag ctgaagaaga tggtgcacaa cctgatggcg
     6241 gaacgtgccg gacaggtggg gcaggtagga caagtgggaa cggtggttac tactccggta
     6301 gtgacgacac accagccttc ggtacctgcg atcattcata ccatgcagcc tgcggtttgc
     6361 aaggatgacg atgacataca agacacggaa gaatatgtag aagaacctcc tttgtcactg
     6421 gacgaagtgg aaaaagaaat gatacgcaaa gcacttgaaa ggcatcacgg aaagcggaag
     6481 agtgcggcca aggacttgaa tatttccgag cgtacacttt atagaaaaat aaaagaatat
     6541 gaattggatt aagaaaataa tacgcccttt gctactgttc ggcttgccgt tggtagtcat
     6601 tgcgtgcact gtttcctata agtttaacgg atcgtctatc aattatgata aggtaaagac
     6661 catttcgata gccgacttcc cgatcaagtc ggagtatgta tatgctccgt tggcaaccaa
     6721 attcaatgag gacctgaaag atatcttcat ccggcagacc cgtctgcaac tgctcaagcc
     6781 gagtcaaaat gccgacttgc agattgacgg agaaatcaca gggtacaatc agtacaacca
     6841 ggcagtatct gccgacggtt attcttcgga gacgaagttg actatcaccg tcaatgtgcg
     6901 ttttgtcaac aacaccaatc atgccgaaga ctttgaacaa cagttttctg cgttccgtac
     6961 ctacgactct acccagttgt tgactgccgt acaggacgga ttgattgctg aaatgtctaa
     7021 agagatcacc gaccaaattt ttaatgcaac tgtagcaaac tggtaatata aatgacttct
     7081 gttaactttc aacaatggat tcagcatccc gagacgctga atagggatac tttgtacgaa
     7141 ctgcgcaatc ttcttgcgag gtatccgtat tttcagtcac ttcgtctgct gtatctgaag
     7201 aatctgtata ttctccatga tattagtttc ggtggagaac tgcggaaagc agttctttac
     7261 attgcagaca gacggcagtt gttccggttg attgaaggtg accgctatga tgtgcaggca
     7321 cggaaaaagg gaatacctct tacggaggtg ctgaaagacg aaccgtccgt agaccgcaca
     7381 ttagcattga tcgacgcttt cttgtccaca gtacccgaag aggtgactgc ccggaccagt
     7441 ttcgactatt cgatggatta cacttcttat cttttggagg agactccggc cacggaacag
     7501 ccggccgaag aaacgcccaa actcaaaggc ttcgaactga ttgacgactt tatagaaaag
     7561 agcgagagcg actctcccct ctgcatgaaa cctttaagag aagaaatgcc atcttcgcca
     7621 acctcttcgg acgaacttac cgaagaagaa acgatgaagg aagaagagga agatgacagc
     7681 tgttttacgg aaactttggc aaaaatctat gttaaacagc aacgatattc aaaagctctt
     7741 gaaataatta aaaaattaag cttgaaatat ccaaaaaaaa atgcttactt tgcagaccaa
     7801 atcagatttt tggagaaatt gattattaac gctaattcaa aataactaaa aatgtactta
     7861 ttattcgtta tcttaatggt tattgcagcc ttgttgatgt gtttcatcgt gctgattcag
     7921 aactcaaaag gaggcggact tgcttctggt ttctcttcat ctaacgccat catgggcgtg
     7981 cgcaagacta cagactttct ggaaaaagca acatggggcc tggccatctt tatggttgta
     8041 atgagcattg ctactgctta tgtagttcct cgctctgctg ttgctaaaga cgcagtgttg
     8101 gaacaggcac agaaagaaca acagactaac ccgtataact tacccgcagg tacggctgcg
     8161 ccgcaaactg aagctcctgc taccaatgca cctgctacag aaactccggc accggctaca
     8221 gaaactccgg caccggctac tgaaactcct gctcctgcag cagagtaatt cactccgtcg
     8281 tcaggtaaga ctttggggta aaaccattaa tgggaaggtg cagacggatg ctgcatttct
     8341 ttgatattta agtgcggatt acgcagatta cacggatttt caatgttccg cgtggtcagt
     8401 gtaatccgca cttaactttt tcttgtaaaa acaatctctt tgtgatagaa acaaacgaga
     8461 tttaactacc tttgttggct gtataagatt attaactact ttttaaatat aacaatgaca
     8521 gaacatttga aacagaaatt gaatgactcc gccgtactcc gatggagtgt tctagcattg
     8581 gtcgcattta ctatgctatg cggctatttc ctcaccgacg taatgtctcc tctaaaaccc
     8641 atgcttgaga aagaactatt atgggatagt cttgattatg gattcttcac aagcgcttac
     8701 ggttggttta acgtattctt gttgatgctg atcttcggtg gtatcatttt ggacaaaatg
     8761 ggagttcgtt tcaccggaat gggagcttgc ttattgatgg tgtttggttg tggattgaaa
     8821 tactatgcga tttctactac ttttccggaa ggtgccatgc tcttcggatt caaaacacag
     8881 gtgacgttgg ctgcattggg atatgctatc tttggtgtag gtgtggagat tgctggtatc
     8941 actgtttcca agattatagt gaaatggttc aagggcaagg aaatggcatt ggctatggga
     9001 cttgaaatgg ctacggcacg tattgggaca actctggcga tggtgttgac agttcctttg
     9061 gcagacttct tcggatatac ggacgagggt ggtgcattcc ataccaatat tcctgctcct
     9121 attctgtttt gtctgattat gctgtgtgta ggtactattg ctttcttcct ttatactttc
     9181 tacgataaga aattggatgc ttctttggat gcagaaggtt tggaaccgga agaaccgttc
     9241 cgtatgaaag atattgtgta tatcattacc aataagggat tctggttgat cgcattgctg
     9301 tgcgtattgt tctactcggc cgtcttccct tttatcaaat atgctgccga cttgatggtg
     9361 cagaaatata atgtagatcc gaaactggcg ggaacgattc ccggattgtt gccgattggt
     9421 gcaattatcc tgactccgtt gttcggttcg ttatatgacc gtatcggtaa aggagccaca
     9481 ttgatggtga tcggatcatt gatgctaatt tttgtacata ccatgtttgc cctgcctata
     9541 ctgaatatat ggtggtttgc tactattata atgattatat tgggatttgc tttctcattg
     9601 gtgccttcgg ctatgtggcc ttctgttccg aagattattc cggaaaaaca gctgggtact
     9661 gcttacgctt tgattttctg ggtacagaac tggggactga tgggtgttcc tttgttaatc
     9721 ggatgggtat tgaatactta ttgcaaaggt ccggtggtag acggtgcaca gacttatgat
     9781 tacacattgc cgatgactat ttttgctctc tttggtgtac ttgctctgat tgtggctttg
     9841 atgttgaagg cagagaacaa gaagaaggga tacggtctgg aagaggcgaa tatccaaaag
     9901 taactgggaa attcaatacc taaagtaaca aaggaatttt gtatcaaggt gtaaacaaaa
     9961 gggtatcagt atgaatactc tgaaataaaa aataagaagt atggctgcca aagagaaaat
    10021 caacctgtta gaggtcattc cctgtcgcag tgaacatatt acagcagaaa gggaagggga
    10081 gacaattgtg ctctcctttc cccgttttaa atatccgtgg atgcaacgct tccttgtgcc
    10141 gaaaggaatg tcgaaagaac ttcatgtgaa attggaagaa cacggtacgg ctgtatggga
    10201 actgatagat ggaaaacgca atgttagtga gattatagaa aaactcgcag accattttca
    10261 aaatgaagag ggctacgagt cgcgtgtatc ggcttatctt tctcaaatgc agaaagatgg
    10321 atttataaaa ctggtgatac cagtcgcata aataggaatt tatatttcac cacagaggac
    10381 acggaggaca cagagttctt ctctctcttt ccgcaagtaa aacagagcga taaatacgat
    10441 tctcaatacg tgagactctg tgttactcta tagtgaataa aaaagattaa acctctgtgt
    10501 cctgcgtgtc ctctgtggtg aatttattat tatttatttg ataaatacag cccaaagtat
    10561 gacggcaatt gctatcagga ctcccatgat aataagcgtt ccccaaacaa aataattgct
    10621 gtctttctct ttctttttct ccgagtcgtg gatgatacgt tccatttctt cgggagtggt
    10681 attgggtagt ggataaggtt cgtttgcacg gtttaaatgc ttcaacttgt cgttagcacg
    10741 ttcacgacgt aggcgggaag cttcccgtcc ctcttttatt cggcgtatca tgtcgaatgc
    10801 atgtccttca ccaaccatat tctttgtttt ttagaagttc actttctcgt ttttctattt
    10861 cccttcttct ctgtccactt tgagcaatcc tcccgtattc ggatcaaaat aaactttgat
    10921 ggtagaattc ttgttgaaca aaaccggagc cagatattct atcacaccaa attgagtaat
    10981 aggaagttca ccttcgtaaa gtttcttttt gccgtcggtc aatgtaacca tagcttgtcc
    11041 gggtacgttg taggcgattc catccaaatc tttcttcttc ttaccatctt cctgtggtat
    11101 cttgaccgat ttcaggtctt tcagactgat ataaaacgga gttcctgcca aatcattgtt
    11161 ggcaactaca cctaacttct tcgagaagcg gaaagcaact tcattgttaa attccttgtc
    11221 aggggtaagg cggacagtga atgttctctc ttccttgttg caggtgccgg agaacatttg
    11281 cgtcatggct tcttcctgtg cattcagatt gtcgagcata atcttaagct gtgctccgtc
    11341 tgaaggcata ttgtcagcct gtccgcgcaa taaggcattt ttgctttcgc ggatgttata
    11401 gatttcttta gccaccagtt cggccatctt ggcggtagag ctagccatca gaatctcttc
    11461 ggtcaggaat tcacgaggat ttgctttctt ttggaggact gtgggagcgg gagcggcttt
    11521 tttgcctaca ctgctgttgc tgtaaggaac attgatcgtt ttcacaatgc catcctctgt
    11581 cagttccatg agcggtgcta ctgtcttatc cttcaatttt acgaaatacg tcgtttcgct
    11641 gttgggcaca cctacggatt tcacttttac gctagtcagt tcccagtact cttcagggtc
    11701 ggcggagacg ttggtcagtc gcaggtaacg atcagcatat ttgctgaatt ctcccggagt
    11761 atagttgact ttgttggctt ttatttcaag ttctatttgg gttttgggaa gactgtaaac
    11821 cactccatag tcttttcctc gggtaacccc tgtcagtact tcggtttgtg cataggcgga
    11881 cgttgtcata agtagtcctg ctgctataat caactttttc atattcggtt ctttttaact
    11941 ggttttgaaa acaaagttaa tgaagttatt gaaaaaactg taagttctta acttttattc
    12001 gcttacaagt cgccatgctg tcggcagaca ggtgataata tcgcttgcga tcattccgat
    12061 cattccttgc ttcttttgag cgacatcgcc cgccaatccg tgaatgtaag tgccgatttt
    12121 agcggcttct ttggtgggat aaccttgggc aagcagcgcc aggattactc cggtcagtac
    12181 gtcaccgcta cctccggttg ccattcccgg atttccggtt gggttgaaga aacatttacc
    12241 ttcgggggtg atgatggcgg agtaggctcc ttttaaaata atgtggacat gggcggcacg
    12301 ggccagttcg caagccttca tcagacgttc gtaagagtcc tggcatttgc cggtcagacg
    12361 ttccagttct ttcggatgcg gggtgaggat ggaacccttc ggcagatggg taagggcatg
    12421 acggtggttg gcgaggatat taagagcgtc ggcatctact acaacaggag tctggcagtg
    12481 ttccagttgt tccaataagg cagcttccgt ttcctcgttt cgtcccagtc ccgggccgat
    12541 gccgactgct tgatagtcgt ccgtgtcggt aggtacggta aaacaggttt cgttgatgtc
    12601 ggtttctacg attgcttcgg gtatggaggt ctgcaagatg tcgttgttgc acattggcgc
    12661 atgaacagtc agcagcccta ctcccgaacg gaggcaggcg cgggcagcga gaacagaggc
    12721 tcctgccatt ccttttgaac cggcaatcaa tagtgcatgg ccgaagttcc ccttgtgggc
    12781 aaactgtttg cgtggcttga tgagtgaacg gatttcttct atttccaaca tttcgtagtt
    12841 agtctccatc tcttcaatac cgtcttcgct taattggata tccagcactt cccattctcc
    12901 gacaaattca gtgttctctg cgaaaagaaa ggcgagcttc ggcagttgca gactgaaagt
    12961 tacgtcggca cggataatat tagcttttac gttgaatgta ttttcttctc ccatcagtcc
    13021 ggaaggaatg tcgatggcta ctaccatggc aggggaggaa ttgatgtatt tcactacggc
    13081 agcgaatcca ccgctcaacg gtttgttcag gcctgaaccg aataatccgt cgattaccag
    13141 atgatcgggc gtcaggacgg gaggtacgaa ttgggtactg atttcgtgga attttacttc
    13201 ttccatcatt tctaccagtt ctttattggt ctggcagtcg ggtgaaagtt ctcctttcgt
    13261 gttgaagaga aatacctcga ttttatatcc tttttcagcc atcatgcggg ctacggcgag
    13321 agcgtctccg ccattattcc ccggtccggc aaagatagtg accggcgttt ccgtattcca
    13381 tctgtctgtg atggcttttg ttaatacggt tgctgcacgt tccatcagat cgattgatgc
    13441 aataggttcg ttctcaatgg tataagcgtc caatttcttg atactgctgc ttggaaatat
    13501 tttcattgcg atgttctttt agttttcgga ttacaaatgt acatgattct tctgactttt
    13561 cccgtttgtt gtgggaagaa aaccataatt gcaactttta attcatcatt agttctatct
    13621 tttggtcaaa gaaatatctg cttttgaact attaagtgtt agaataactc cgccaaaaaa
    13681 taattcaatg ctgcaccatt atgaacttac ttttatttct ccctgaaaaa gatttctggt
    13741 tcttcgtcaa atttggtggt acttcttcta ttgtgaataa agaat
//
