LOCUS       c00041_gnlPro..        16770 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PGJDPBJI_44.
ACCESSION   c00041_gnlPro..
VERSION     c00041_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 13:07:28
            Original ID  :: gnl|Prokka|PGJDPBJI_44
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 80894
            Orig. end    :: 97664
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16770
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[90894:95451]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14557
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..16770
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16770
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="2"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             435..629
                     /locus_tag="ctg41_52"
                     /transl_table=11
                     /translation="MKKTELALLYMPYASADVARRHLNKCIRRNRELLEALEATGWAFW
                     IHWLTPLQVELIEKYLGEP"
     CDS             complement(626..826)
                     /locus_tag="ctg41_53"
                     /transl_table=11
                     /translation="LDCTLEEMAVLKYLQEKPNATQKEIAQHIGKSERTVKTMTVNLSE
                     RGIIERKNGRRNGFWEIKNRD"
     CDS             complement(920..2719)
                     /locus_tag="ctg41_54"
                     /transl_table=11
                     /translation="MDRFKELGIDTHGRTSGKMKTKCPWCHAQRTDKRDKSLSVNLDTK
                     LYLCHYCGAHGSAAIYAGKGRKLGDPLVKFPTATGSNSSCPPTEKPHGDPEQGALTQKQ
                     IEWCRDVRHIPPEVLVEAGVAFASISMPISGKEKGWEKRDCLCFNFFENGELVNTKFRD
                     SQKHFKLLQGARTIPYNIDAIRDTPECILVEGEFDALSYMAVGRTDVISVPNGANSQLD
                     WLDELSESHFEQKQVIYLSVDTDRKGRELCRELSRRLGVDRCRIVTYGEAYKDANELLV
                     AEGPNALLKALEDAPIPRLEGTFTAEDLREGLHQLFEEGYTSGVELGIPNLDEIMRLET
                     GRVLTVTGIPGHGKSDFVDEIVLRLCTRQDWRAGYFSPENTPIEYHHAKLAEKLLGHRF
                     RKDFSTEEEFARVVDYLSQRVWHILPDGDFTLGNVLSKARELVHRHGIRVFVIDPYNYI
                     NHQIPAGMTETGYIGSFMNSLARFARLNSCLVILVAHPRKMNKQYGTQKTEVPTMYDIN
                     GSANFFNMTDYGIVVDRQDEMGIVYIHVEKTRFRNFGTKGNAAFCYDVTNGRYSPCTPP
                     PEPGMQVQPWKGAKDLFSSEGWI"
     CDS             complement(2748..4052)
                     /locus_tag="ctg41_55"
                     /transl_table=11
                     /translation="MTTSNSANTKQSNNASQKRKPIHNGYFNHPTSSSSNIPMSILIRE
                     QGLEIYGLYWVMLEEAHAQLKCCVNIQTMEIIANIFHAQPEHLELLYHHYFRRPGKGYN
                     SHILYADFCEESAIRSYFPHPLLAYTDNELLRMIMQDGLKAYGLYWLVMEKLYQQPQHF
                     LAPQTASFIQNLYDVSDELMESVLYNYGLFYLDEKMNLHSKAIDDYREALDNMEDEKKR
                     NTKPHVNNSLKANGNAEDFNTREMKKTSNIQKNPSPIINKEINKKNSSSEENGKEKEEE
                     NGLKVTDLNAVTPDMRPNAWEENLQEAMNDTSWYEVVAIQSGIPRLMMEEKEWFFNYLR
                     EQIILRGNESSMNSLHEIKNYFANLTRQGSHVSSTTQVALKRFLKNRQEQQQCSPYETI
                     TNGIRTYDGHPIPAYAKPRPSAAHIWNPVTNEWTR"
     CDS             4457..4801
                     /locus_tag="ctg41_56"
                     /transl_table=11
                     /translation="MHVIVWEKPVGGVFVVGAAEIVFIFCQCPCNGKAGSVCSLQAEIG
                     VVPSHPVYQFFYLVCTAHRFSQCQQCAVILFRILADNSCPTGNRQATVILHRFFHTDFF
                     VLKCSHFSSC"
     CDS             4857..5015
                     /locus_tag="ctg41_57"
                     /transl_table=11
                     /translation="MDDWLNKWNKIFCIFHCLNIGFKELMEEFKESCGGNGNRLQRAKD
                     GPLYPLW"
     CDS             complement(5064..5495)
                     /locus_tag="ctg41_58"
                     /transl_table=11
                     /translation="MPKWISVEKAVIKYHIEKEAILLWVEMGQFPMLYIDNVPNVDEEC
                     ILELFRRSKAGITAEYIDTLEQLCIDKTMVCEKYAHIIQLKEKEIQLQKEINTLINEIQ
                     AAMKRQNERIRDLKKAIGENNNVIRSDSWIKRLRKRFQW"
     CDS             complement(6228..6635)
                     /locus_tag="ctg41_59"
                     /transl_table=11
                     /translation="MEITDLKQMTKEEVFNFIRQRLSFSKELQEQFRHVNKDDLAKEHR
                     RFEMSGNESKTGQCTIFNTAILNEFADLGIYDYTSYLFLDFHNGTPTVYLKYFSENENL
                     EYTFTGYTTTEIIFAILELTIFSGKPKRNRS"
     CDS             6829..8043
                     /locus_tag="ctg41_60"
                     /transl_table=11
                     /translation="MINREQYMEQIVPFIDKPFVKVITGIRRSGKSVVLRLIRDELLRR
                     GVREERIIYLNFESFQWIDLKEAKALYAYIRGQAGDAGKYYILLDEIQEVDGWEKVVNS
                     LLVDLDTDIYVTGSNSRMLSSELATYLTGRYVAFHVMTLSFREYLTFHDLQANDPTLNR
                     KEEFQKYLRMGGFPAIHTADYGYEAIYKIVYDIYSSVILRDTVQRHNIRNVELLERVVK
                     FVFDNIGNKLNAKNIADYFKSQQRKVDMNTIYNYLNALESAFIIQRIPRYDIKGKEILQ
                     TNEKYFVSDLSLIYSVMGYRDRLIAGMLENLVCLELKRRGYEVYVGKQDDKEVDFVAIR
                     REEKIYVQVTYQLASQATVEREFASLLAINDHYPKYVVSMDSLWQDNVEGVRHRHIADF
                     LLDDA"
     CDS             complement(8124..8378)
                     /locus_tag="ctg41_61"
                     /transl_table=11
                     /translation="MKKGLHPESYRPVVFKDMSNGDMFLSRSTVATKETIEFEGETYPL
                     LKIEISNTSHPFYTGKSTLVDTAGRVDKFMSRYGDRKKK"
     CDS             8812..9816
                     /locus_tag="ctg41_62"
                     /transl_table=11
                     /translation="MVNYKDLGLVNTREMFAKAIKGGYAIPAFNFNNMEQMQAIIKAAV
                     ETKSPVILQVSKGARQYANATLLRYMAQGAVEYAKELGCAHPEIVLHLDHGDTFETCKS
                     CIDSGFSSVMIDGSHLPYEENVALTKKVVEYAHQFDVTVEGELGVLAGVEDEVSADHHT
                     YTDPEEVIDFATRTGCDSLAISIGTSHGAYKFTPEQCHIDPVTGVMVPPPLAFEVLDAV
                     MEKLPGFPIVLHGSSSVPQEEVATINQYGGALKAAIGIPEEWLRKAAKSAVCKINIDSD
                     SRLAMTAAIRKTFAEKPAEFDPRKYLGPARDNMEKLYKHKIINVLGSDNKLAQ"
     CDS             complement(10001..11161)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg41_63"
                     /sec_met_domain="OAD_beta (E-value: 3.9e-153, bitscore:
                     501.6, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDFINFLGNNLADFWTYTGFANATVGHVVMILVGLVFIYLAIAK
                     EFEPMLLIPIGFGILIGNIPFNMDAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYMIALEMGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRLLTTKNERVIRMKPPRAVSHTEKVIFP
                     IIGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDTITILLGLTVGAS
                     TQASEFLTLDSIKIFALGALSFVIATASGVIFVKIFNIFLKKGNKINPLIGNAGVSAVP
                     DSARISQVIGLEYDSTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             complement(11163..11594)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 67.7; E-value:
                     2e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg41_64"
                     /sec_met_domain="Biotin_lipoyl (E-value: 2.3e-21, bitscore:
                     67.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNSYKVTIGDIEDNIAHVEVNGTHYKVEMEKQPKPV
                     AKPVTVRPMPNAPAAPTQVVKPTAPSTGKSGVKSPLPGVILDIKVNVGDTVKKGQTIII
                     LEAMKMENNINADKDGKITAINVNKGDSVLEGNDLVIIE"
     CDS             complement(11619..12539)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg41_65"
                     /sec_met_domain="OAD_gamma (E-value: 3.8e-15, bitscore:
                     48.5, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKIGIFLSLLLLIGLTSCGEQKSNNKLVLNEILIDNQSNFQD
                     DYGLHSAWIEIFNKSFGSADLAACLLKVSSQPGDTVTYFIPKGDILTLVKPRQHALFWA
                     DGEPNRGTFHTSFKLNPETANWVGLFDSGKKLLDQIVVPAGTLGPNQSYARVSDGAAEW
                     EVKSGSGDKYVTPSTNNKTLDSNSKMEKFEEHDADGVGMSISAMSVVFCGLILLFIAFK
                     IVGKVAVNLSKRNAMKSKGIDKHEAKELSQAPGEVYAAISMALHEMQDEVHDVEETVLT
                     ITRVKRSYSPWSSKIYTLRETPPRK"
     CDS             complement(12571..14124)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg41_66"
                     /sec_met_domain="CT_Btheta (E-value: 1.1e-289, bitscore:
                     952.9, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIERRAVARIGGGEKAIAKQHEKGKYTARERLAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYVFAQDFTVSAGSLS
                     ETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAKTEEEGFELIRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDSPT
                     KPYDMYEVIGAIVDNGEFLEIQKDYAKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKDQENPAQFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRVIRALQQLQTKKLSNPAKKHGNIPL
                     "
     CDS             complement(14153..14557)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg41_67"
                     /sec_met_domain="Glyoxalase_4 (E-value: 1.8e-23, bitscore:
                     75.1, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVRTA
                     FLKVGETKIELLEPTCPESTIAKFIENKGAGVHHVAFAVEDGVANALAEAEGKEIRLID
                     KAPRKGAEGLNIAFLHPKSTLGVLTELCEH"
     CDS             complement(14733..15731)
                     /locus_tag="ctg41_68"
                     /transl_table=11
                     /translation="MPLKLTTYYHGKDIPELPGKNAFHSKELFQIYEATPGYTPLLIVA
                     TEDGRPMARLLAAIRKAKKWLPSSLVKHCVVYSEGEFLDESLSTNKEKAEEVFGDMLEH
                     LTQEASRSCVLIEFRNLNNSMFGYRVFRANDYFPVNWLRVRNSLHSMKKTEDRFSPSRI
                     RQIKKGLKNGAKVEEAHTVEEIHDFSRMLHKVYSSRIRRYFPANDFFRHMNNMLIKGQQ
                     AKIFVVKYKEKIIGGSVCIYSGDDAYLWFSGGMRKTYALQYPGVLAVWKALEDAHQRGF
                     RHMEFMDVGLPFRKHGYRDFVLRFGGKQSSTRRWFRINWSWLNKLLVKFYV"
     CDS             15971..16768
                     /locus_tag="ctg41_69"
                     /transl_table=11
                     /translation="MRCNAFVEAWKNHHRRASMILGLSLLSAPLSYSVYAEDGVSNTMV
                     QVVTQTKTVKGTIIDESGEPLIGVSIVVKGTSTGTITDFNGNFSIDLPAGRKELVISYI
                     GYKEQTVTVTGNGPVNVKMVSDTQALDEVVVVGYGTMKKRDLTGAITSVKSEDVVMNPS
                     SNPMQALQGKVAGLDITRESGQAGSGVKMQLRGNRSFQKDSGNPLFIIDGMPGDYSTLN
                     PNDIESIEVLKDASSTAIYGSSGANGVILTSNPQLSSSASFLRL"
ORIGIN
        1 gagcaactgc tcgcgcatca ctgccatcag gtttcggatc acgttgtgca cgtcaccggc
       61 cgtcagtgat gaccgttcgg caatcgtttc gccaatcatt tgcgtatcca ctacgtttcc
      121 cattttaatc aggcagggat gccatttctt ctttttgtcc ttcgatgcga tattggactg
      181 aaccgctttg taaatcaaca tactgatttc ctccttttta agtgaataaa taagatttta
      241 ttgagtcagt aaacgaacgt tttctgtctc ttttacagta gcaaagatac cccaaccggc
      301 aggggaggaa acatgaaacg gtatctgccg gtaagtgaag gcaaacgctt gaatatctgt
      361 gtatttgctt gcatttctac gcaaaaaaca gtatctttac atgacgtaaa taataaatta
      421 aaagaagaaa atctatgaag aaaacggaat tggcattact ctatatgccg tatgcaagtg
      481 ccgatgtggc aagaagacat ttaaataaat gcatccgccg aaaccgggag ctgctggagg
      541 ctctcgaagc taccggctgg gcgttttgga tacattggct cacaccgttg caggtggagc
      601 tgattgagaa gtatttggga gagccttaat ccctattttt gatctcccaa aaaccattac
      661 gacgaccgtt tttacgctct atgatgcccc tttcgctcaa gttgacagtc atggttttaa
      721 cggttctttc agactttcct atatgctggg caatttcttt ttgtgttgca ttaggttttt
      781 cttgaaggta tttcagtacg gccatttctt ccaaagtgca atccaaagtg caatttttgc
      841 actttggatt ttctgtctct gtttgttttg cactttgagt agcttgcttt tcaagttatt
      901 cttgtagcag ccttaatccc taaatccatc cctctgacga gaataagtct ttggctccct
      961 tccacggttg cacctgcatg cccggttcgg gtggtggcgt acaaggggaa tatcttccgt
     1021 tggtcacatc gtagcagaac gctgcgtttc cctttgttcc gaaattacgg aaacgggttt
     1081 tctcgacgtg tatatacacg atccccattt catcctgacg gtctaccact attccgtagt
     1141 ccgtcatgtt gaaaaagttg gccgagccgt tgatgtcata catggtggga acttccgttt
     1201 tctgcgtgcc gtattgcttg ttcatctttc tcggatgcgc caccagaatg acgaggcagg
     1261 agttgagccg ggcaaaacgt gccagactat tcatgaatga accgatatac cctgtctccg
     1321 tcatgcctgc cgggatctga tggttgatgt aattgtacgg gtcgatgaca aacacacgga
     1381 tgccgtgacg gtgtaccagt tcgcgtgcct tcgacaagac gttgcccagt gtgaaatccc
     1441 cgtccgggag aatgtgccag acgcgttgcg aaagataatc cactacgcgg gcgaattcct
     1501 cctccgtaga gaaatctttg cggaaacggt gtcccagcag tttctccgcc agtttggcat
     1561 gatgatactc gattggcgtg ttctccggac tgaaatatcc cgctcgccaa tcttggcggg
     1621 tgcagagccg gagcactatc tcatccacaa agtccgattt gccgtgtccg ggaataccgg
     1681 tgacggtgag cacccgcccc gtttccagcc tcatgatttc gtccagattc ggtattccca
     1741 attccacgcc cgaagtatac ccctcttcaa acagttggtg caatccctcc cgtaagtctt
     1801 ctgccgtaaa cgtaccttcc aggcggggga tgggcgcgtc ctccagtgcc ttcagtagtg
     1861 cgttcgggcc ttccgccacg agcagttcgt tggcgtcctt gtatgcttcg ccgtaggtga
     1921 cgatacggca gcggtctacc cccagccgtc gggagagttc ccggcatagt tcccgtccct
     1981 tgcggtcggt gtccaccgac agataaatca cttgtttctg ctcgaaatga gattccgaca
     2041 attcgtccag ccagtccagt tgactgttgg caccgttcgg cacggaaatg acatccgtcc
     2101 ggccgacagc catgtaggag agggcatcaa attccccttc cacgaggatg cactccggcg
     2161 tgtcgcggat ggcgtcgatg ttgtaaggga tggtgcgcgc tccttgcagt aatttgaaat
     2221 gcttttgtga gtcgcggaac tttgtgttca ccaattcccc gttttcgaaa aagttgaagc
     2281 agagacagtc cctcttttcc cagcctttct cctttccgga tataggcatc gagatggagg
     2341 cgaaagccac gccagcttcc accaatactt ccggcggaat gtggcggacg tcacgacacc
     2401 attcaatttg cttctgtgtg agtgcccctt gctctgggtc gccgtgcggc ttttcagtgg
     2461 gcggacaact ggagttgcta cctgttgccg ttggaaattt gaccaacgga tcacccagct
     2521 ttctgccttt tccggcatat atggctgccg aaccgtgtgc gccgcagtag tggcacaaat
     2581 acagtttggt atcgaggttg acacttagtg atttatcacg cttatccgtc cgttgggcat
     2641 gacaccaggg acattttgtt ttcattttgc cgcttgtgcg accgtgggta tcaataccca
     2701 gttctttgaa tctatccata tttagtaaat gattgagaga taatatgcta tcgtgtccat
     2761 tcgttcgtca ccggattcca gatatgtgcc gccgaaggtc gcggcttggc ataagcgggg
     2821 atgggatgcc cgtcgtaggt acgtattccg ttggtgatgg tttcgtaggg cgaacattgc
     2881 tgttgctctt gccggttttt gagaaacctc ttcagtgcca cctgcgttgt ggatgacaca
     2941 tggcttccct gccgggtgag attggcgaaa tagtttttta tttcgtgcag gctgttcatc
     3001 gagctttcat tcccccgtaa gatgatttgc tcccgtaaat agttgaagaa ccattctttt
     3061 tcttccatca tcagccgggg gatgcccgac tgaatggcta cgacttcata ccaggatgtg
     3121 tcgttcattg cctcctgtag attttcttcc catgcgttgg ggcgcatatc gggtgtcaca
     3181 gcgttcaagt ccgtcacctt caaaccattt tcttcttctt tttcttttcc gttttcttca
     3241 gaagaagaat tttttttgtt tatttcttta tttataatgg gggatggatt tttctgtata
     3301 tttgacgttt ttttcatttc ccgagtgtta aaatcctctg catttccgtt ggctttcaga
     3361 gagttattga cgtgcggttt cgtgttgcgc tttttttcat cttccatgtt gtcaagtgct
     3421 tccctataat cgtctattgc tttagaatgg aggttcattt tctcatccag ataaaagagt
     3481 ccgtaattgt ataatacact ttccatcagt tcgtcgctca catcataaag gttctggatg
     3541 aaggaagcag tttgcggtgc cagaaaatgt tgtggctgtt gatagagctt ttccatcaca
     3601 agccaatata gtccgtaggc tttcagtccg tcttgcataa tcatccgcag cagttcgttg
     3661 tcggtgtatg ccagtagggg gtgcgggaaa taacttctga tggcagattc ttcgcaaaag
     3721 tcggcataga gtatatgcga gttgtatcct ttaccgggac gccggaaata atggtggtag
     3781 aggagctcaa gatgttcggg ttgggcatgg aatatattgg cgatgatttc cattgtctgg
     3841 atattgacgc agcatttaag ctgtgcatga gcttcttcga gcatcaccca gtatagtccg
     3901 tatatttcca gtccttgttc ccgtatcaaa atactcatgg gtatattgct ggaagaagaa
     3961 gtgggatgat tgaagtaacc gttatgaatc ggttttctct tttgtgatgc gttgttcgat
     4021 tgtttggtat ttgctgaatt agatgttgtc ataataaaat atattagttt ctgttttaaa
     4081 ttctattttt ctgaaaatac agatacgaag aatccggcca cttctttgga aagcagcaaa
     4141 tatcgtactc attcttcatg atggaatcgg agtattctct tcgtgtatgt aatctgtaat
     4201 atagggaatt ttcggagcag gggagattta attccgaagt tctgaaaaag caatgcagga
     4261 aaaacagata actgcctctg tcaaaaaaca aggaagcagc attgacatga ttttttctct
     4321 tacttgcggt tgcaaagtaa ctactttatt tcgtatatgt cctacaactt tccttattta
     4381 atccatgaaa ttaatttttt ttcacagaag agccgaatac aatccctgcc actcgacacg
     4441 taagccattt tctacaatgc acgtcatagt atgggagaaa cctgttggag gggttttcgt
     4501 agtaggggcg gccgaaatag tgttcatatt ctgtcagtgt ccctgtaatg gaaaggcagg
     4561 ttccgtctgt tcgttgcagg cagaaatcgg cgttgtccca tctcatccgg tctatcagtt
     4621 cttctacttg gtatgcacgg cgcatagatt ctcccagtgt caacagtgtg ccgtaattct
     4681 cttccgcatc ttggcggata atagctgccc gacgggaaac cgtcaggcaa ctgtcattct
     4741 tcatcgtttt tttcatacag atttctttgt gctgaaatgc tcacatttca gttcttgtta
     4801 gtggtgtaaa tgtagtgaat ttacttgact ttacaaagga taaaattact tatataatgg
     4861 atgattggtt aaataaatgg aataaaatat tttgtatttt tcattgtttg aatataggct
     4921 ttaaagagct tatggaggag tttaaagaaa gctgtggagg gaatgggaat aggctgcaaa
     4981 gggcaaagga cggccctctt tatcctctgt ggtgaaaacc gtgcaataat gtcccacatg
     5041 gtaattggta cactgataat tattcaccat tgaaaccttt tgcgcagcct ttttatccaa
     5101 ctgtcactac gtataacgtt gttattctct ccaatcgctt ttttcaaatc ccggatccgt
     5161 tcattttgtc tcttcattgc tgcctgtatt tcgtttatca acgtatttat ttccttctgc
     5221 agctgaattt ccttttcttt caattgaata atgtgggcgt atttctcgca gaccattgtt
     5281 ttatctatgc acagttgttc cagtgtatca atatattctg ctgtaatgcc ggctttactt
     5341 cggcgaaaga gttccagaat acattcttcg tcaacgttcg gaacattgtc tatgtataac
     5401 ataggaaatt gtcccatttc cacccaaagc aggatcgctt ctttttcgat gtgatactta
     5461 atcactgctt tttctacact aatccatttt ggcatattgc ttttgtttta atgtgttata
     5521 aaaaaaggag taaataacgt attgtccgga gaggtgcaac gaacacccac gatttttatg
     5581 atttcggtcg ggtggggaat tggttggggt ataaggattg ttgaaaccga ccggatacaa
     5641 taaaagcgtg agtgctgttg taccattatc taaacttgag gcttagcaac acccttgtag
     5701 aagacaatga taacaacaga cacccacgcc aaacgtttat atataacaca tctctaatcg
     5761 atatgttgat atacgaccat ctacgtggag tatctgctgt atcatctctc tctacaaaga
     5821 actgctaatt ttcaagtttg agagacaata cgttatttac tccattaagg aataaaaacc
     5881 gcttttgcct gtttcatcac gctgatgggc agaaagcgta tgacaaagat atatgttttt
     5941 ttcggaatag gatggaaaag aggaaataaa tgcaggaaat atggtatgag aatagagagt
     6001 atggtataaa gatggtaaat atgctatacg ggtggcaaat ataatgtgat gataaaaagg
     6061 agggagccaa aagtaaaacc atctccaaga ttgatattat ttaggcacgg attacacgag
     6121 tttcacggtt ttagtctaat ggaaccgtga aatccgtgta atccgtgcct aaatgaaagc
     6181 cataaaagtc ttttgacctc gcattgtctt tccgtgcaat tcttttttta gctgcgattt
     6241 cttttgggct ttccggagaa gatagtcagt tcaagaattg caaagatgat ttccgttgtg
     6301 gtatatccgg taaatgtata ttccaaattt tcattttcgg agaagtattt gagataaacg
     6361 gttggagtgc cattgtggaa gtcgagaaaa aggtaagaag tataatcata gatgccaaga
     6421 tcggcaaact cgttcagaat cgctgtgttg aaaatcgtgc attggcctgt ctttgattca
     6481 tttccggaca tttcgaatct gcgatgttct tttgcgagat cgtctttatt cacatgcctg
     6541 aattgttctt gcagttcttt actgaaagaa aggcgttgtc tgatgaaatt aaaaacttct
     6601 tcctttgtca tttgttttaa atcggttatt tccatttttt attaattagt cgggtaaagg
     6661 tactttcttt atttggtaat aaatcggatt tagtcatatt tcttttattt atttttcggc
     6721 ttataaccct aaaagaatct gaatttatgg aattatttag ggttataacc ctaaaaactt
     6781 tccgaaaata gtatatcttt gtgcttataa ccctaaaaac ttttgaatat gattaatcgt
     6841 gaacagtata tggaacaaat tgttcctttt atagacaagc cgtttgtaaa agtgataacg
     6901 ggtattcgtc gcagtggaaa gtcggtagtg ctgcgtctga ttcgtgacga actgttgagg
     6961 agaggagttc gtgaagaacg tatcatctat ctgaattttg aaagttttca gtggatagat
     7021 ctgaaagagg cgaaggcttt gtatgcttat attcggggac aggcgggaga tgcgggtaaa
     7081 tattatattc tcttggatga aattcaggaa gtggacggtt gggaaaaagt ggtcaactca
     7141 cttctggtag atttggatac ggatatttat gtgaccggct ccaactcacg tatgttatcg
     7201 tccgaactgg caacttattt aacgggacgg tatgtcgctt tccatgtcat gaccttgtct
     7261 tttagagaat atctgacttt ccatgacttg caggccaatg atccgacgct caatcggaag
     7321 gaggaatttc agaaatatct ccgtatggga ggattcccgg ccatacatac tgccgattat
     7381 ggatatgagg ctatctataa aattgtctac gacatctatt cttctgtcat tcttcgtgac
     7441 acggtgcagc gtcacaatat ccggaatgtg gaattgctcg aacgggtagt gaagtttgtt
     7501 tttgataata taggcaataa gctgaacgct aaaaatatag ctgattactt caaaagtcag
     7561 caacggaagg tggatatgaa taccatctat aattatctga atgcattgga aagtgctttt
     7621 atcattcaac gtattccccg atatgatatt aaaggaaagg aaattctgca gacgaatgag
     7681 aagtattttg taagcgacct ttctttgatt tattccgtga tgggctatcg tgaccggttg
     7741 attgcaggta tgttggagaa tctggtctgt ctggagttga aaagaagggg ttatgaagtg
     7801 tatgtaggca aacaggatga taaagaagtg gattttgtag ccatccgtcg ggaagaaaag
     7861 atttatgtgc aagtaacgta tcagttagct tcacaggcca ctgttgagag ggagtttgct
     7921 tctttgctcg ccattaacga ccattatcct aaatatgtag ttagcatgga cagcttgtgg
     7981 caggataatg tggaaggtgt caggcatcgt catatagccg atttcttgtt ggatgatgct
     8041 tgacgttaag gaatatagaa aacgaaaaag aggaaattct ctgcgagaat ctcctctttt
     8101 ttcatctttc acgaaagatc gaattatttc ttcttacggt caccgtaacg gctcatgaac
     8161 ttgtcaacac gacctgcagt atctaccaat gtagatttac ctgtatagaa cgggtgagaa
     8221 gtgtttgaga tttcaatctt cagcaacgga taagtttcac cttcgaattc gatggtttct
     8281 ttagttgcta cagttgatct agacaaaaac atgtcaccat ttgacatatc tttaaatact
     8341 accggacggt atgattctgg atgaaggcct tttttcattt cagtatctgt ttttttaatt
     8401 tatattctgt tactattttg gtaagaaata gtgtaatggt cattttcaga gcgcaaagat
     8461 aatgcttttc tgtgaaatag aaaaaggttt tctaaaattt ctgatttcta atttatgatt
     8521 tctgatttgc tatgcagatt ttggtgatta aatgaatgaa aaatgaggta taaataaggt
     8581 ataaataagg agatataaat ccgaaggcat caatcagaat tcagaaatca taaatcccaa
     8641 agtttgcaag gtggacatta caatctaatg tcacactcgt attcctgcta aattttgcag
     8701 tctgatttaa acctttttct actatatttt tctttccgat gttcgttatt cgatggataa
     8761 tgcttacttt tgcgtagaat ttttattcac taacaataaa ctttaaacaa aatggtaaat
     8821 tacaaagatt taggattggt aaacacaaga gaaatgtttg ctaaggctat caaaggtgga
     8881 tatgctatcc cagcattcaa cttcaataat atggaacaaa tgcaggctat catcaaggct
     8941 gctgttgaaa ctaaatctcc tgtgattctt caggtttcta aaggtgctcg tcagtatgct
     9001 aacgctactt tgttgcgtta catggcacag ggtgctgtag aatatgctaa agaattaggc
     9061 tgcgcacatc cggaaatcgt tcttcacctt gaccacggag atacattcga aacttgcaaa
     9121 tcttgtatcg attctggttt ctcttcagta atgatcgatg gttctcacct tccttacgaa
     9181 gaaaacgtag cattgactaa gaaagttgtt gaatacgctc accagttcga cgtaactgta
     9241 gaaggtgaac ttggcgtatt ggctggtgta gaagatgaag tttctgctga ccaccacaca
     9301 tatactgacc ctgaagaagt aatcgacttc gctactcgca ctggttgcga ctctttggct
     9361 atctcaatcg gtacttctca cggtgcttac aagtttactc cggaacaatg ccacatcgac
     9421 ccggttacag gcgtaatggt tcctcctcca ttggcattcg aagtattgga cgctgtaatg
     9481 gaaaaacttc cgggattccc tatcgttctt cacggttcat cttcagttcc acaggaagaa
     9541 gtggcaacta tcaaccaata cggtggtgca ttgaaggctg ctatcggtat tcccgaagaa
     9601 tggttgcgta aggctgctaa gtctgctgtt tgcaaaatca acatcgactc tgactcacgt
     9661 ctggctatga ctgctgctat ccgtaagact ttcgctgaaa aaccagctga attcgaccca
     9721 cgtaagtatc ttggcccggc tcgtgacaac atggaaaaac tgtacaagca caaaatcatc
     9781 aacgtgctcg gttctgacaa caaattggca cagtaataat ctccggatta ttccataaat
     9841 aaaagaaaga ggctgctccg gtttgaacac tggtagcagc cttttttatg acgtttaatc
     9901 gtttcagaac ggagagaaga taacactatg gctgtaataa agaacacccg tgtcacaact
     9961 gaatgtaaca cgggtgttct tatctattat ataatgtttc ttacatcaag aatccaagca
    10021 gaataccggc agcaacagct gaaccgatca ctccggcaac gttcggaccc atagcgtgca
    10081 tcagcaaata gttggtcgaa tcgtattcca aaccaatcac ttgtgagata cgtgcagagt
    10141 cgggaacagc agagacacct gcattaccga tcaacggatt gatcttatta cccttcttca
    10201 ggaagatatt gaagatctta acgaagatga caccggatgc cgttgcaata acaaatgaca
    10261 atgcaccgag ggcaaagatc ttgatagagt cgagcgtcag gaattcggat gcttgtgtag
    10321 aagcacctac tgtcagaccc aacaggatag tgattgtatc aatcaacgga ccactggcag
    10381 tattagccaa acggcgggtt acaccacttt ctttcaacag gttaccgaag aacagcatac
    10441 ccagcaaagg cagaccggaa ggaaccagga aacaagtcag caacaaaccg atgatcggga
    10501 aaatcacttt ctccgtgtga gaaacggcac gcggcggttt catgcggatg acacgttcgt
    10561 tcttggtggt gagcagacgc atgataggcg gctgtatcac cggaaccaac gccatatagg
    10621 agtaggcgga caccgcaatg gctcccatca ggttaggtgc tagcttggaa gaaaggaaga
    10681 tggccgtcgg gccgtctgct ccaccaatga taccgatagc accggcttgc atcggatcga
    10741 agcccatttc tagcgcgatc atataagcac cgaagatacc gaattgtgca gctgcaccga
    10801 tcagcatcaa ttttggatta gagataagtg ccgagaagtc cgtcatggca ccgataccca
    10861 aaaagatgag tggcggatac cagccggagg tcactccctg atacaatata ttcaatacag
    10921 aaccttcttc ataaataccg actttcagcc cggcatccat attaaaaggt atattaccga
    10981 tcaatatacc gaaaccgata ggaatcagca gcatcggttc gaactctttg gctattgcca
    11041 aatagatgaa taccaagcca acgagaatca tgactacatg ccctaccgta gcattggcaa
    11101 agcctgtgta tgtccagaag tcggctaggt tatttcctaa aaagtttata aagtctccca
    11161 tattattcaa taattacgag gtcattacct tcaagaacag agtctccctt gttgacgttg
    11221 atggcagtaa tcttaccgtc cttatccgca ttgatattgt tttccatctt catggcttcc
    11281 aatatgataa tggtctgtcc tttctttaca gtatcgccta cattcacttt gatgtcgagg
    11341 atcacacccg gcagcggaga ttttactcct gattttccgg tagatggagc ggtcggtttc
    11401 actacttgag taggagcagc aggagcatta ggcatcgggc gtactgtcac gggtttcgca
    11461 acaggcttcg gctgtttctc catttctact ttatagtgtg taccgttcac ttctacatga
    11521 gcgatgttgt cttcaatatc tccgatggtt actttatatg agttaccgtt gattttatat
    11581 ttatattctt tcatcgtttt tactttttaa aaggtgactt actttctggg aggagtttca
    11641 cgcaaagtgt aaatcttcga actccatggt gagtagctgc gttttacgcg ggtgatggtc
    11701 agcaccgttt cttctacgtc gtgcacctca tcctgcattt cgtgtaatgc catagaaata
    11761 gcagcgtata cttcgcccgg agcctgtgac agttccttag cttcatgctt gtcaattcct
    11821 ttagatttca tagcgttgcg cttgctcaaa ttaacagcta cttttcctac aatcttgaaa
    11881 gcaataaaga gaagaatcaa tccgcagaat actacgctca tggcagaaat ggacattcca
    11941 acgccatcag catcgtgttc ttcaaacttt tccatcttgg aattgctgtc aagagtcttg
    12001 ttgttggtgc tcggagtcac gtatttgtca ccgcttccac tttttacttc ccattcagct
    12061 gccccgtcgc ttacacgagc gtatgattga ttgggaccga gagtgcctgc gggcactaca
    12121 atctggtcga gcaacttctt gccggagtcg aacagaccaa cccaattagc tgtttccgga
    12181 ttcagcttga agctggtatg gaaagtacca cggttaggtt cgccatctgc ccagaatagt
    12241 gcatgttggc ggggtttcac taaggtaagt atatcacctt tcgggataaa ataagtaact
    12301 gtatcgcccg gttggctgct tactttcagc aagcaagctg ccaggtcggc gctaccgaat
    12361 gatttattga atatttcaat ccatgcgctg tgcaatccgt aatcgtcctg aaaattactc
    12421 tgattgtcta tcaggatttc gtttagcacc agcttattgt tcgacttttg ctctccacaa
    12481 gaagtcagac caatcagcaa cagcaaagaa aggaatattc cgattttggt tttgttcata
    12541 atcgttcttg ttttaatgtg aaaagtagga ttacaacgga atattaccat gcttcttagc
    12601 cggattgctc aatttcttag tctgcaactg ctgcaaagca cggatcacac ggaaacgtgt
    12661 gttgcgcggt tcaatcacat cgtcgatgta gccatattta gctgcattgt aaggattggc
    12721 gaacaatttc gtgtattctg cttctttctc tgcaaggaat tgagcagggt tttcctgatc
    12781 tttggcttcg cgtgcgtaca atacttctac tgctcctgct ccacccatta ctgcgatttc
    12841 agcagtcggc catgcgtagt tcatgtcacc gcgaagttgc ttacagctca ttacgatgtg
    12901 agaaccaccg taggatttac gcaatgtaat cgtaacctta ggcacagtag cttcaccgta
    12961 agcatacaac agtttagcac catgaaggat aacgccattg tattcctgac ctgttcccgg
    13021 aaggaatccc ggtacgtcta ccaacgatac gataggaata ttgaatgcat cgcagaaacg
    13081 aacgaaacgt gcacccttac gagatgcgtt gctatcgagc acaccagcca gatacttagg
    13141 ctgattagca acgataccta ccgattgtcc gttgaaacgg gcgaaaccga tgatgatatt
    13201 ctttgcataa tctttctgga tttcaaggaa ttcaccgttg tccacaatag cgccgatcac
    13261 ttcgtacatg tcatacggtt tagtagggct gtcggggata atatcgttca aagaatcttc
    13321 cagacggtcg attgggtctg tgcaatctac ataaggagct tcttcgaggt tgttttgagg
    13381 aatataactc aacagtttac gaatcagctc gaaaccttct tcttctgttt tagcggtgaa
    13441 atgagtcaca cctgatttag tggagtgaac gcttgcgcca ccgaggtttt cctggctaac
    13501 gtcttcacct gttacggtct tcacaacttt tggtccggta aggaacatat aagaagtacc
    13561 ttccatcatt agcgtgaagt cggtcagagc cggagaataa acagcaccgc cggcacaagg
    13621 accgaagata cctgaaatct gtgggataac accggaagca aggatattgc gttggaagat
    13681 ttctgcataa cctgccaaag cgttgatacc ttcctgaata cgtgcaccac ccgagtcgtt
    13741 gataccgata cagggagcgc ccatcttcat ggcttgatcc atgattttac aaattttcaa
    13801 tgacatcgtt tctgacagtg aaccggcaga aacagtgaag tcttgtgcga acacatatac
    13861 cagacgtcct tcgatcgtac cgcagccggt tactacaccg tctcccgggt aatgtttttt
    13921 ctccatgccg aagttcgtgc atctgtgctc aacgaacatg tccatttctt cgaagctacc
    13981 ctcgtcaagc agcatagcca gacgctcgcg tgctgtgtat ttcccttttt cgtgttgctt
    14041 cgcaattgct ttttcaccgc ctccgatacg tgctacggca cggcgttcaa taagctcttt
    14101 aattttttca agttgattac tcatgagttc ttgttggttt tagagtttat gattaatgtt
    14161 cgcagagttc tgttaacaca cccaaagttg atttcgggtg aaggaaagcg atattcaaac
    14221 cttcagcacc tttgcgggga gctttgtcga taaggcggat ttctttgcct tctgcctctg
    14281 ccagcgcatt ggctacgcca tcttctacag caaatgcgac gtggtgaacg cctgcacctt
    14341 tgttttcaat gaatttggca atagtactct ccgggcaagt aggctccaac agttcaattt
    14401 ttgtttcgcc cacttttaaa aaagcagttc ttactttctg atcttccact gtttcaatgt
    14461 tgtaacactt cagacctaat acattttcgt agtaaggaag ggcttcttcg atgcttttta
    14521 cagcaatgcc cagatgttca atgtgtgaaa tcttcataac tatacttttt ttatttggtt
    14581 ttaaatctgt gcttataagg cataaaacag cacaaagaaa gacatttctt atctaataaa
    14641 gaaatatttc tgcatttaat tattggatta ttaaacagaa aaaatggtgg gaaaggagca
    14701 taaaacattg ttttgtaatc ttgagattac atttagacat aaaacttgac taagagtttg
    14761 ttcagccaac tccaattgat gcggaaccaa cggcgggtac tgctttgttt tcctccgaag
    14821 cgaagaacga aatcacgata accgtgttta cggaacggaa gtcctacatc cataaattcc
    14881 atgtggcgga atccccgttg gtgtgcgtct tccaatgctt tccaaacggc tagcacaccc
    14941 ggatattgaa gtgcgtatgt ctttctcatt cctccggaaa accaaaggta tgcgtcgtct
    15001 cccgaataga tacagacaga accgccaatg attttctctt tgtatttcac aacgaatatt
    15061 tttgcctgtt gtcctttgat taacatattg ttcatgtggc ggaaaaagtc gttggcaggg
    15121 aaatatctgc gtatgcggga ggaataaacc ttgtgcagca tccgtgagaa atcgtgtatt
    15181 tcttccacgg tatgtgcctc ctctactttg gctccattct tgagtccttt ttttatctga
    15241 cggatgcgcg acgggctgaa ccggtcttcc gtctttttca tactgtgcag cgaattgcgt
    15301 acccgcagcc agttgacagg gaaataatca ttggcacgga aaacccggta accgaacatc
    15361 gaattattga ggttccggaa ttcgatcagg acacagctac gcgatgcttc ttgtgtgaga
    15421 tgttcgagca tatcgccaaa gacttcttct gccttttctt tgttggtcga aagcgactca
    15481 tccagaaatt caccttcgct atatactacg caatgtttca ctaaagagga gggaagccac
    15541 tttttcgctt tgcggatggc ggcaagcagg cgtgccatag gtctgccgtc ttctgttgcc
    15601 actattaata aaggagtata gcccggagtc gcttcataaa tctgaaataa ctctttggaa
    15661 tggaaggcgt tttttcctgg taattcagga atgtccttcc catgataata tgtggttagt
    15721 ttaagtggca tctaggtaca aatttacact ttttattctt tattcaacaa caaaacaaag
    15781 aatttgttgg agctgcttga agtaaagtat aatatatagt tgcgtattta atggagaaaa
    15841 tatattttat aggagaaata tggtatgaaa agtgagtacg tattaaaatt agattcgtct
    15901 ttaattaaga ttataatcga atagtttttg caaaacaacg agaattaata ttaactttaa
    15961 attagaacga atgagatgta atgcatttgt tgaagcatgg aagaatcatc atagacgcgc
    16021 ttccatgatt ttagggctgt ctttattgtc tgcccctctg tcatattctg tgtatgcaga
    16081 agatggagtt tctaatacta tggtgcaagt tgtcacacaa acgaaaactg tgaaaggaac
    16141 tatcattgat gaaagcgggg agccgctgat tggagtttct atcgttgtga aaggaacaag
    16201 tacaggtacg attaccgatt ttaacggtaa cttctctatc gatcttccgg cgggaagaaa
    16261 agaactggtc atttcttata tcggttacaa agaacaaacg gtgacagtga caggcaacgg
    16321 accggtcaat gtgaaaatgg tttcggacac acaggcattg gatgaagtgg ttgttgtggg
    16381 ttacggtacg atgaaaaaac gcgatttgac aggagctatc acttctgtaa aaagtgaaga
    16441 tgtagtgatg aatccaagtt caaatccgat gcaggcttta caaggtaagg tggcaggatt
    16501 ggatattacg cgtgaatcgg gacaggccgg ttcgggagta aagatgcagt tgcgtggtaa
    16561 ccggtcattc cagaaggatt ccggaaatcc tttatttata attgatggta tgccggggga
    16621 ttattctaca ttgaatccga atgatattga aagcattgaa gttttaaaag atgcttcttc
    16681 gacagctatt tatggttcaa gtggtgcgaa cggtgttatt ttaacctcaa atccgcaact
    16741 aagctcttca gcgtccttct tgcgtctaaa
//
