LOCUS       c00045_gnlPro..        15204 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JHBHHDBH_45.
ACCESSION   c00045_gnlPro..
VERSION     c00045_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 12:25:28
            Original ID  :: gnl|Prokka|JHBHHDBH_45
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15204
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15204
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1690:5204]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1691..5204
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..15204
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15204
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             complement(32..157)
                     /locus_tag="ctg45_1"
                     /transl_table=11
                     /translation="MKYVKPNQVSHLSDDEIEKLIKDYYDGVKIKDIIEIYKINR"
     CDS             610..1479
                     /locus_tag="ctg45_2"
                     /transl_table=11
                     /translation="MPGDSFCIQYTNCTGCPKNVENILVYRNLPKGEHIPKDKCTQNCM
                     LFMIKGELLINSEEHPGITLRERQIVLQAIGSKVEILALTDVEYVVYWFNELPLLCEER
                     YKEMMEQAEAPLTYTPLIMSERLYHLVTSMPEFLAEENPCSKYIDLKCKELVFLITNFY
                     PLPQLGSFFYPISTYTESFHYFVIQNYSNVKNVEEFAHLGGYTTTTFRRLFKNLYGMPV
                     YEWILEKKREGILEDLQHTKMRITEICNRYGFDSLSHFAHFCKDSFGDTPRALRKKAAS
                     GEKIGKVQ"
     CDS             1691..2395
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_3"
                     /sec_met_domain="SucD_FumR (E-value: 1e-130, bitscore:
                     426.9, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWLSNSSVGRKVVMSVTGIALVLFLTFHMAMNLVAIISADGYNMI
                     CEFLGANWYALVATAGLAALFVIHIIYAFWLTMQNRKARGSERYAVTDKPKTVEWASQN
                     MLVLGLIVIVGLGLHLFNFWAKMQLPELMHNMGMHADTLTLAYAANGAYHIQQTFSCPV
                     YVVLYLVWLFALWFHLTHGFWSSMQSLGWNNKVWIDRWKCISNIYSTIVVLGFALVVVV
                     FFVKTLICGGAC"
     CDS             2433..4412
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 201.7; E-value:
                     7e-62)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_4"
                     /sec_met_domain="FAD_binding_2 (E-value: 2.4e-61, bitscore:
                     201.7, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 3.8e-36,
                     bitscore: 117.7, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKIDSKIPEGPVAEKWTNYKAHQKLVNPANKRRLDIIVVGTGLA
                     GASAAASLGEMGFRVFNFCIQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTVKG
                     GDYRAREANVYRLAEVSNAIIDQCVAQGVPFAREYGGTLDNRSFGGAQVSRTFYAKGQT
                     GQQLLLGAYSALSRQVNVGTVKLYTRYEMQDVVIVDGRARGIIAKNLVTGELERFAAHA
                     VVIATGGYGNAYFLSTNAMGCNCTAAISCYRKGAVFANPAYVQIHPTCIPVHGDKQSKL
                     TLMSESLRNDGRIWVPKKKEDAVKLQKGEIKGSDIPEEDRDYYLERRYPAFGNLVPRDV
                     ASRAAKERCDAGFGVNNTGLAVFLDFSEAINRLGIDIVLQRYGNLFDMYEEITDVNPGE
                     LAKEINGVKYYNPMMIYPAIHYTMGGIWVDYELQTTIKGLFAIGECNFSDHGANRLGAS
                     ALMQGLADGYFVLPYTIQNYLADQITVPRFSTDLPEFAEAEKAVQAKIDKFMSIQGKES
                     VDSIHKKLGHVMWEYVGMGRTAEGLKKGIAELKEIRKEFETNLFIPGSKEGMNVELDKA
                     IRLYDFITMGELVAYDALNRNESCGGHFREEYQTEEGEAKRDDENFFYVACWEYQGDDE
                     KAPVLYKEPLVYEAIKVQTRNYKS"
     CDS             4449..5204
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer4_7"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_5"
                     /sec_met_domain="Fer4_7 (E-value: 1.6e-11, bitscore: 38.5,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer2_3 (E-value: 1.1e-24, bitscore: 80.3,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 6.9e-06, bitscore: 20.2,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKNISFTLKVWRQAGPKAKGAFETYQMKDIPGDTSFLEMLDILN
                     EQLISERKEPVVFDHDCREGICGMCSLYINGHPHGPATGATTCQIYMRRFQDGDTITVE
                     PWRSAGFPVIKDLMVDRTAYDKIMQAGGYVSVRTGAPQDANAILIPKPIADEAMDAASC
                     IGCGACVAACKNGSAMLFVSAKVSQLNLLPQGKPEALRRAKAMLSKMDELGFGNCTNTR
                     ACEAECPKNISISNIARLNRDFIIAKLKD"
     CDS             complement(5326..6165)
                     /locus_tag="ctg45_6"
                     /transl_table=11
                     /translation="MPSICQGTWDCQICPKAVSNAITHVIYQRGFHKPAQRCEENFILF
                     LIKGEMLVNSKEYAGTMLKEGEFILQAIDSTFEMLAMLECECIYYRFIQPELFCDSRFN
                     HIMKDVSPPLIYSPIKIVPELQYFLQGSITYLKGNKVCRDLLSLKRKELAFVLGYYYSD
                     YDLSSLVHPLSKYINSFHYFVIQNYKKVKTVEELAQLGGYTLSTFRRIFNNVFHEPVYE
                     WMLARRKEGILDDLNNSAYSISEICYKYGFESLPHFSNFCKKSFGASPRNLRGQNRS"
     CDS             complement(6464..7462)
                     /locus_tag="ctg45_7"
                     /transl_table=11
                     /translation="MKKILLAVTAALAIMSCSQNEEFEAPNQQTKIDFTSVVRKATRAT
                     DTNSNNFLGFTVSSYITDGDYNGTDALGAAYMDGISYTKDNAAAPWTTTDKGTYYWPSI
                     SSGKKVQFFAYPTTDPTSYSLPDASYPTISFTVDGTPADQKDLVVAHATNVTSESSKVA
                     DGTLTLDFKHVLTRINFAFIPDDPLLTYAVTAVSIADVKGGTGKYSFNADNGEWNLAAA
                     ATSSYSYAVKQSADKVENKNYYSLADTNASWMLFPQEVNGKVISITYSTKQGAMEVFSG
                     TKKVTLPSDAKWTVGQNVLYVLTLPAGAAKVGLNTEVSEWNTADEKEETAK"
     CDS             complement(7518..8501)
                     /locus_tag="ctg45_8"
                     /transl_table=11
                     /translation="MLLVLLSSLLVLNGCSRRDILDDYPVSGVEISLNWDGVTDKLPEG
                     IRVIFYPKDGEGKKVDRYLSVRGGEMKVPPGRYSVVAYNYNTESIRIRGEESYETIEAY
                     TGNCNGLGITGTEKMVWSPDSLYVLNIDELKIDKSEEVLSLDWKLESVVKKYSFAIEVK
                     GLEYVTAIVGCINGLSDCYHIGKGYGASSSQPIYFEVKKDGNKVVAYFTAFKQAKEMSV
                     PTRISESRSATSRGVGDIKLILRFIKTDNTVQEAAIDVTEIIETLEDTGTGDDGKQDPP
                     PEIELPSDDKIEVDKPELPPNPDGGGGMDGNVDGWGPEDNVELPVI"
     CDS             complement(8529..9806)
                     /locus_tag="ctg45_9"
                     /transl_table=11
                     /translation="MKHGIFILAILMALLSLPESGYAAVPFFTVINDTIRRVVIYFDAN
                     ETNVNHCYRSNKEAIITLDSLLSGNSDTKYITALNVVSFVSPDGDESYNKSLVTKRNNS
                     IKEFLRRYELVNNVDKIHFCSKGEDWLEFRKLVASDTNLPDREEVLMLIDYHKDDIAKR
                     KQLLRKLNRGAAYRYMVRNVFPELRRSVITIVGETGIIDREAFEPVSSVSGLFVSNQEE
                     ALPKNQPDKPVGESEDKQTCEVDMSEAEEPVKSKTVLAVKNNLLYDLALAPNIEVEIPI
                     GKRWSLNTEYKCPWWLNSKHDFCYQLLSGGMEGRFWLGNRQKRDRLTGHFIGLYAEGGI
                     YDFQLRGDGYQGKYYGAAGVTYGYAKQLAQHFSLEFSLGIGYLTTEYKKYTPYEGDIVW
                     TNSGRYNFIGPTKAKVSLVWLITTKR"
     CDS             complement(10040..10528)
                     /locus_tag="ctg45_10"
                     /transl_table=11
                     /translation="MGLEYVVTKRVFGFDKDKNEKYVAKSVRSGKVNFAKMCRKVSELC
                     GVHRKVVDLVVSGLVDKMAEDIDDGKSVQMGEFGIFTPTIRAKSTDDEKEVSSKSIVQR
                     KILFYPGKIFKNTLEDMSITRRAEIETDYTDGSSNGGNNGGNPDSGDDGKGEAPDPAA"
     CDS             10742..10885
                     /locus_tag="ctg45_11"
                     /transl_table=11
                     /translation="MFNTLTYQWIAIEILTAKSLPVTFTLNVYKQRRLQPHHRLQPDLF
                     IK"
     CDS             complement(10912..12759)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HMGL-like"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PYC_OADA"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg45_12"
                     /sec_met_domain="HMGL-like (E-value: 1.1e-17, bitscore:
                     58.2, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 6.4e-18, bitscore:
                     58.9, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKQTFIFVYVKLTKEKNHLLLAMMKKEIKFSLVYRDMWQSSGKY
                     QPRVDQLVRIAPLIVEMGCFTRVETNGGAFEQVNLLYGENPNKAVRAFTAPFREAGIQT
                     HMLDRGLNALRMYPVPADVRKLMYKVKHAQGVDITRIFCGLNETRNIIPSIKYALEAGM
                     IPQATLCITYSPVHTVEYYARIADQLIEAGAPEICLKDMAGIGRPGMLGQLVRTIKEKH
                     PDVLIQYHGHSGPGLSMASILEVCENGADIIDVAMEPMSWGKVHPDVISVQAMLKDLGF
                     QVPDINMKAYMKARAMTQEFIDDFLGYFMDPTNKYMSSLLLKCGLPGGMMGSMMADLKG
                     VHSGINMILRSKNEPELSLDDLLVMLFDEVEYVWPKLGYPPLVTPFSQYVKNVALMNLM
                     QLVKGEERWTMIDNHTWDMILGKSGRLPGTLAPEIIELAKSKGYEFVDTDPQLNYPDAL
                     DDYRKEMDENGWEYGEDDEELFELAMHDRQYRDYKSGVAKKRFEDELQHAKDASMAKSG
                     YSEEDIKKLKRAKADPVIAPDNGQVLWEVSVEGPSIAPFIGRKYQHDEVFCYLSTPWGE
                     YEKILTGFTGRVVEICAQQGATVRKGDVIGYILRSDIFA"
     CDS             complement(12921..13313)
                     /locus_tag="ctg45_13"
                     /transl_table=11
                     /translation="MDTLKLHSHFENLLYVGRSVLTNTSSRIQRLFFKKEMCIYEYLFK
                     EEASKGIEIVVDNAVLVCVFENDICNKSILYLNDSTNVTSYINYCNSTFEYDKLRDRWI
                     MPDGYLTLFMPNDDFEKRFAFVQTLV"
     CDS             complement(13808..14029)
                     /locus_tag="ctg45_14"
                     /transl_table=11
                     /translation="MRRILSFAVLAALYFPGCTTSKNAVRCLSRWIKDCNPLTKELVPT
                     GYMPYNHRYLTMKQYKIITKHLGDPYED"
ORIGIN
        1 tcgctacgct tttctcaaat ttacttttta gctatctgtt tattttatat atttctatta
       61 tatcctttat cttaacgccg tcatagtagt cttttattag tttttctatt tcatcatcgg
      121 acagatgact tacctggttg ggttttacat atttcatgat aattttatat ttgtcgcctt
      181 attttttatt tacggcaaag ataatgcttt ctttaagatt acgggtgcaa aaataaaaga
      241 gaatggacga aaaatatccg gagatgcagg aattacccga aaagtgctat aatagctacc
      301 atactctttt taaaagcctt tcaaattact tttcaactcc ttattttctc aaagtattct
      361 caccgtgatg agaattattc cccgctgtac ttccctgata atgtgaaaat aatcttaccg
      421 atcatgatca ataagacctt tttgtttttc acaataaagt tgcaatattt agttataaat
      481 tcattccact atatttaaag acgaccatac aaaggcttct accaaaacat aaatagaaga
      541 aagagttcca ttttccgcaa aaaaagccta tctttgttcc gttaagataa taaatcacgc
      601 ataagactca tgccaggaga ttcattttgc atacaatata ctaactgtac aggatgtcca
      661 aaaaatgttg agaatatcct tgtatataga aacttaccta aaggagagca tatccccaag
      721 gataagtgta cgcagaattg catgcttttt atgataaagg gcgaattact tatcaatagc
      781 gaagagcatc ccggaataac gttacgcgag agacaaattg ttttgcaagc tattggctcc
      841 aaagtcgaaa tactggcact gacagatgtt gaatacgttg tctactggtt caacgaactg
      901 cctttgctct gcgaagaacg gtataaggaa atgatggaac aggcggaagc tcctttgacc
      961 tacactccac tgattatgag tgaaaggctt taccaccttg tcactagtat gcccgaattc
     1021 ctcgctgaag aaaacccttg cagcaagtat atcgatttaa aatgcaaaga actggttttc
     1081 ttgattacca acttctatcc gctgccccag ctaggttcat tcttctatcc aatcagcact
     1141 tatacggaaa gtttccacta tttcgtcata cagaattaca gcaacgtgaa gaacgtagaa
     1201 gaatttgcac atctgggagg atacacgacc actactttcc gccgcctttt caaaaaccta
     1261 tatggtatgc ccgtatatga atggatactg gaaaagaaac gggaaggaat cctggaagac
     1321 ctgcaacaca ccaaaatgcg aatcactgaa atctgtaaca gatacggatt cgactccctg
     1381 tcgcatttcg cacacttctg taaagactct ttcggcgata ccccacgcgc tttacgcaaa
     1441 aaagcagcca gcggtgagaa aatcggaaag gtacaataaa cagtcccatc ctacgaatgt
     1501 gccaatcagt tgcaccatgc atatatactg gctggcatat tgacacattg gcgtattgat
     1561 ccattattaa ggaattattt ctttaattcc ttgctcaatc aatctatttc ccctattttt
     1621 gcagtccgta agaggtgtaa aacgtcgaaa ttttagttct aacaattaaa taatttaaat
     1681 tcaatcattt atgtggttaa gtaattcatc tgtaggaagg aaagtggtga tgagcgttac
     1741 cggtatcgcc cttgtcctgt ttctaacatt tcacatggcg atgaacttgg ttgcgatcat
     1801 ctcggctgat ggttacaaca tgatttgtga gttcctggga gcaaactggt atgcattagt
     1861 ggctaccgca ggactggctg ctcttttcgt aattcacatt atctacgcat tctggctgac
     1921 aatgcagaat cgcaaagcgc gtggtagcga acgctatgca gtgacagaca aaccgaaaac
     1981 tgtagaatgg gcatctcaaa acatgttggt gctgggtctt atcgttatcg taggtcttgg
     2041 tttgcacctc ttcaacttct gggcaaaaat gcagttgccg gaactgatgc acaacatggg
     2101 catgcacgct gatacattga cattggctta tgctgctaac ggtgcatatc acattcagca
     2161 gactttctct tgtccggttt acgtagttct ttaccttgtt tggctgtttg ctttgtggtt
     2221 ccacctgact cacggtttct ggagttcaat gcaatcactg ggatggaaca acaaagtatg
     2281 gattgatcgt tggaaatgta tttctaacat ctattctaca atcgttgtac tcggtttcgc
     2341 actggtagta gtggtattct ttgtgaaaac acttatttgt ggtggtgctt gctaaatagt
     2401 aaattgtaaa tgattaaatt gtaaataata ttatgatcaa gatagattca aaaattccag
     2461 aaggcccggt ggctgagaaa tggaccaact ataaagctca ccagaaattg gtgaaccccg
     2521 ctaataaacg ccgtttggac atcatcgttg tgggtacggg tctggcaggt gcttctgccg
     2581 ctgcttcact cggtgaaatg ggtttcagag tattcaattt ctgtattcag gattctcccc
     2641 gtcgtgcaca ctctatcgct gcacagggtg gtatcaatgc tgcaaagaat tatcaaaatg
     2701 acggtgactc cgtttaccgt ctgttctacg atactgtaaa aggtggtgac tatcgtgccc
     2761 gtgaagctaa cgtatatcgt ctggctgaag tgtctaacgc tatcatcgac caatgtgtag
     2821 cacaaggtgt tcctttcgct cgcgaatatg gtggtacact ggacaaccgt tctttcggtg
     2881 gtgcacaggt atcccgtact ttctacgcta aaggccagac cggtcagcag ttgttgctgg
     2941 gtgcttactc tgcattgagc cgtcaggtaa acgtaggtac tgtaaaactg tacactcgtt
     3001 atgaaatgca agatgtggtg atcgttgacg gacgtgctcg cggtatcatc gctaaaaatc
     3061 ttgtaacagg tgaactggaa cgctttgccg ctcacgctgt agttatcgct accggtggtt
     3121 atggtaatgc ttacttcctg tctaccaacg ctatgggatg taactgtaca gctgctatct
     3181 cttgctaccg caagggtgct gtattcgcta accctgctta cgttcagatt cacccgactt
     3241 gtatcccggt acacggtgac aagcagtcta aactgacttt gatgtctgaa tctctccgta
     3301 acgacggtcg tatctgggtt ccgaagaaga aagaagatgc tgtgaaactt caaaaaggcg
     3361 aaatcaaagg aagtgatatt cctgaagaag accgcgacta ttacttggaa cgccgctatc
     3421 cggcattcgg taacctggtt ccgcgtgacg ttgccagccg tgctgctaaa gaacgttgcg
     3481 acgcaggttt cggtgtaaac aacactggtt tagccgtatt ccttgacttc tctgaagcta
     3541 tcaaccgctt gggtatcgac atcgttctcc aacgttatgg taacctcttc gatatgtatg
     3601 aagaaatcac tgacgttaat ccgggagaac tggcaaaaga aattaatggc gtaaaatatt
     3661 ataatccgat gatgatttat ccggctatcc actatacaat gggtggtatc tgggtagact
     3721 acgaactgca aaccactatc aagggtctgt tcgctatcgg tgaatgtaac ttctccgacc
     3781 acggtgcaaa ccgcctcggt gcttctgcat tgatgcaagg tttggctgac ggttacttcg
     3841 tattgcctta tacaatccag aattatctgg cagatcaaat cactgttcct cgtttctcta
     3901 ctgatcttcc tgaatttgct gaagcagaaa aggcagttca agctaagatc gacaagttca
     3961 tgagcatcca gggtaaagaa tctgttgatt ctatccacaa gaaactgggt catgttatgt
     4021 gggaatatgt aggtatggga cgtacggcag aaggcttgaa gaaaggtatt gccgaactga
     4081 aagaaatccg caaggaattc gaaacgaatc tgtttatccc cggttctaaa gaaggtatga
     4141 acgtagagct tgacaaagca atccgtctgt acgacttcat cacaatgggt gagcttgttg
     4201 cttacgatgc attgaaccgt aacgaaagtt gtggtggtca cttccgtgaa gaataccaga
     4261 ctgaagaagg agaagctaaa cgtgatgacg aaaacttctt ctatgtagca tgctgggaat
     4321 atcaaggtga cgatgaaaaa gctccggtgt tgtacaaaga accgctggta tacgaagcta
     4381 tcaaggttca aacccgtaac tacaagagct aatcggtgaa gttaaacatt taaaagaatt
     4441 agaagaaaat ggataaaaat atatcattta cactgaaggt atggcgccaa gctggtccga
     4501 aggctaaagg tgcttttgaa acctaccaaa tgaaagatat ccccggcgat acttccttcc
     4561 tcgaaatgct ggatattctg aacgaacagc tcatcagcga aagaaaagaa ccggtagtat
     4621 tcgaccacga ttgccgcgaa ggtatctgcg gtatgtgttc tctttacatc aatggacacc
     4681 cgcacggtcc tgcaacaggt gctactactt gtcagatcta tatgcgtcgt ttccaggatg
     4741 gtgatacgat tactgttgaa ccttggcgtt cggccggttt ccctgtaatc aaggacttga
     4801 tggtagaccg tactgcttat gacaagatta tgcaagctgg tggttacgtg agcgtacgta
     4861 caggtgctcc gcaggatgct aacgctatcc tgattccgaa gcctatcgct gacgaagcta
     4921 tggatgctgc ttcttgtatc ggttgtggtg cttgtgtagc tgcatgtaag aatggttctg
     4981 ctatgttgtt cgtttctgca aaagttagcc agttgaactt gctgccgcaa ggtaaaccgg
     5041 aagctttgcg tcgtgcaaaa gctatgttgt caaagatgga tgaactggga ttcggtaact
     5101 gtacaaacac tcgtgcttgt gaggctgaat gtccgaagaa catctctatc agcaacatcg
     5161 cccgcttgaa ccgtgacttc atcatcgcaa aattaaaaga ctagaaattg ctagatttcg
     5221 agagcgagag cttaatttga ttaatgacag aatcccctgc cggctagtcc gacaggggat
     5281 ttctttatat atgaatggat catgattatt attaataatc agttatcatg aacggttttg
     5341 tccacgcaaa ttacgtggag aagcgccgaa agatttctta cagaaattag agaaatgggg
     5401 taaggactca aaaccatatt tatagcatat ctcggaaata ctataagcag aattattcaa
     5461 gtcatcgaga ataccctctt tacggcgtgc cagcatccat tcataaactg gttcatgaaa
     5521 gacattattg aaaatacgac ggaatgtgct aagggtatat cctcctaatt gggctagttc
     5581 ttctacagtc tttactttct tatagttttg aataacaaag tagtggaaac tattgatgta
     5641 cttagagagc ggatgcacca gactcgagag gtcataatca gaataataat accccaacac
     5701 aaatgccaac tctttccgct tgagagacaa caaatcccgg cagactttat ttccttttaa
     5761 ataagtgatg gaaccctgca aaaaatattg tagttcagga actatcttta ttggggaata
     5821 gataagtgga ggcgatacat ctttcattat atgattgaaa cgagaatcac aaaacaattc
     5881 cggttgaata aaacggtaat agatgcactc acattcgagc atggcaagca tctcaaatgt
     5941 agaatcaata gcttgaagta taaattcacc ttctttgagc atggtaccgg catattcctt
     6001 actattaacc agcatttctc ctttaatcaa gaaaagaata aaattttcct cacacctctg
     6061 agctggttta tgaaaaccac gctgataaat aacatgagta atagcattgc tcactgcttt
     6121 cggacatatt tgacaatccc aagttccttg acaaatagat ggcataagct ggctgtgttt
     6181 gtatttgttt atgctgccaa caaaaatata tgaaagattt catattgcca taaaaaaagg
     6241 gaagaaaagt gaaaaagaag ttgcacgaag aatctaaaac atatctagtt ttgaaaactg
     6301 aactaaatct ccatataaaa gataaataac ctcacaagat ctcatacaaa gttctgtgtt
     6361 aataaagaaa ccctagctcc tcgaaaagaa gagctaggat ttaaaatatg cttaacctag
     6421 aaataattct catttatgct aaatcatgga cagtgccatt ttatcattta gcagtctcct
     6481 ctttttcgtc tgcagtattc cattcgctaa cctctgtatt aagcccaact ttagcagcac
     6541 cggcaggtaa tgttaataca tatagcacat tttgaccaac tgtccatttg gcatcactag
     6601 gaagagttac ttttttagtt cctgaaaaga cttccatcgc accctgtttc gttgaatatg
     6661 ttattgatat aaccttacca tttacttctt gaggaaatag catccaagat gcattagtat
     6721 cagccaaaga ataataattc ttattttcaa ccttatctgc tgattgttta acagcataac
     6781 tatatgatga agtagcagca gcagccaaat tccattcacc attatctgca ttaaaactat
     6841 atttacctgt tccaccttta acatcagcta tactaacagc agtcactgca taagtaagca
     6901 aaggatcatc aggaataaac gcaaaattta tacgggttag aacatgttta aaatctaggg
     6961 tcagtgtacc atcagctact ttactcgact ctgaagtaac attagttgca tgtgcaacaa
     7021 ccaaatcttt ttgatccgca ggagtgccat caacagtgaa agatattgta gggtagctag
     7081 cgtcaggaag agaataggac gtaggatctg tcgttgggta tgcaaagaat tgtacttttt
     7141 ttcctgaact tattgatggc caataatacg ttcctttatc ggtagtagtc caaggtgcag
     7201 cagcattatc tttcgtatat gagattccat ccatgtatgc agctcctaaa gcatctgttc
     7261 cattatagtc accatctgta atataagaac ttacagtgaa ccctaaaaag ttattactat
     7321 ttgtatctgt agctcttgta gctttcctta ctactgaagt aaaatcaatc tttgtttgtt
     7381 gattcggcgc ctcaaattcc tcattttgtg agcaactcat aattgctaaa gcagctgtta
     7441 ctgccaataa aattttcttc ataactgtat tttttaaaag tttataatat tgttctattt
     7501 tgtttataac atctatttta aatcacaggt aattcaacat tatcttccgg tccccaccca
     7561 tcaacattgc catccattcc tccaccccca tcaggattcg gcggtaactc tggcttatca
     7621 acctcaatct tatcatcaga cggtaactca atctccggtg gagggtcctg ttttccatca
     7681 tctcctgttc cagtatcttc aagtgtctct attatttcag taacatcaat tgctgcttct
     7741 tgcaccgtat tatccgtttt gataaatctc aagatcaact ttatatcgcc tacaccacgg
     7801 gaagttgcgc tccttgattc tgatattcgt gtcgggactg acatttcctt tgcctgcttg
     7861 aaagctgtga aatacgccac taccttatta ccatctttct ttacctcaaa atagataggc
     7921 tgcgaggaag atgctccata acctttacca atgtggtaac aatcagatag tccgttaata
     7981 caccctacga ttgctgttac gtactccaaa cccttgacct ctatcgcaaa agaatacttc
     8041 ttcactaccg attccagttt ccaatccaaa gaaagcacct cttcactctt atctattttc
     8101 agttcatcaa tattcagcac atacagtgag tccggtgacc aaaccatctt ttccgttcct
     8161 gtaatcccta aaccattgca gtttcctgta taagcctcta tcgtttcata ggactcttct
     8221 cctcggatac gtatggactc cgtattatag ttgtaagcta caaccgaata tcgtcccgga
     8281 ggaactttca tttctccacc tcgtaccgaa aggtacctgt ccactttttt accctcacca
     8341 tctttcggat aaaatataac ccggatacct tctggtaatt tatctgttac tccatcccag
     8401 tttaatgaaa tttctacccc acttacagga taatcatcca atatatcgcg acggctacac
     8461 ccgtttagca ccagcagcga ggacagaagc acaagaagca tgaatcttgc atttcgcata
     8521 acgccctcct atctctttgt tgttatcaac cataccaaag aaacttttgc tttggtagga
     8581 ccaataaagt tataacgccc actatttgtc catacaatat ccccctcata aggagtatat
     8641 ttcttatatt ctgttgtcaa ataccctatg ccaagactga attcaaggga aaagtgctgt
     8701 gctaattgct ttgcatatcc ataagtcact ccagcagctc catagtactt accctgatac
     8761 ccatctccac gtaactggaa atcgtatatt ccaccttcag cataaagtcc aataaaatgt
     8821 ccagtcaatc ggtcgcgctt ctgccggttt cccagccaaa aacgtccttc catgcctcca
     8881 gaaaggagct gatagcagaa atcgtgttta ctattcaacc accacggaca tttatattca
     8941 gtattcaaag accacctctt acctatcgga atttctactt ctatattcgg tgccaatgcc
     9001 aaatcatata atagattgtt ctttactgca agcactgttt tgcttttcac cggctcttct
     9061 gcctccgaca tatcgacctc acaggtctgt ttatcttcac tttctcccac aggcttatca
     9121 ggttgattct tcggaagcgc ctcttcctga ttcgaaacaa acaacccgga gacagaagat
     9181 accggttcaa aagcctctct atctattatc ccagtttctc cgacaatcgt tataacagac
     9241 cgcctcaatt ccggaaatac attacgaacc atatatcggt aggcggctcc ccgatttagc
     9301 ttacgcaaca gttgctttct tttggcgata tcatccttat gatagtcaat caacatcagc
     9361 acttcttccc ggtcgggtaa gttggtgtca gatgccacca acttacgaaa ctccaaccaa
     9421 tcctctccct ttgaacagaa atgaatctta tcaacattat taactaattc atatcgcctc
     9481 aagaattcct ttatcgagtt atttctctta gtaaccaaac ttttattata agattcgtca
     9541 ccatcaggag aaacaaaact cactacattt aacgctgtta tatatttcgt atccgaattt
     9601 ccggacaaca aggaatctaa tgttataatt gcctctttat tactcctata acaatgattc
     9661 acattcgttt cattcgcatc gaaatatatc accacccgtc ggattgtatc attaataaca
     9721 gtaaaaaatg gtaccgcagc atacccactt tctggaaggc ttaacaaagc cataagaata
     9781 gccaagataa agataccatg tttcattgtc gttcgtttct gttgacaaat atagaagtta
     9841 gaaaataaat caaatcatac tttcaggaga aaatacaggc cctgaaaggt tctgtgaaac
     9901 gattgaaacg attttgcaag tttgaggagt ataaaaggca gaaaatcata taaaaagaat
     9961 gcacagataa ccaatctatc gatcgattct ctgtgcattc actaattaaa ggcttgcttt
    10021 aatacaaagt tcagtccaat tatgcagccg ggtccggtgc ttcccctttg ccatcatcgc
    10081 ccgaatcagg gttaccccca ttattccccc cattactact tccgtccgta taatccgttt
    10141 caatttccgc acggcgggta atactcatat cttccagcgt atttttgaag atttttcccg
    10201 gatagaataa gatctttctc tgaacgatcg acttggatga gacctccttt tcgtcatccg
    10261 tactcttagc acggatagta ggagtgaaga taccaaactc acccatctgc acgctctttc
    10321 catcatcaat atcctccgcc atcttatcca ccagaccact gacgaccaaa tctaccacct
    10381 tacgatggac accacaaagc tcacttactt tccgacacat ctttgcaaaa ttcaccttac
    10441 cggaacgaac cgattttgcc acatactttt cgtttttgtc cttgtcaaaa ccgaacactc
    10501 tttttgttac tacgtactct aaacccataa ttgttaaagt ttaattggtt aaaaaataaa
    10561 ggttatctgt ttgtcattct ctttgtttga atgactctgc aaaggtatat caaccgtaaa
    10621 acgtccggtc cccttttgtc tcctttcatc gtttggaatc aattattatc ggaagagaat
    10681 attgctagtt atcaacagga tatatcaaag aattattttt ttcataaaat gcgtattttc
    10741 catgttcaac actctaactt atcaatggat agccattgaa attctaacag ctaaaagcct
    10801 tcctgtaact tttacattga atgtctacaa acaaagaagg ctgcaacctc atcacagatt
    10861 gcagcctgac ctttttataa agtaacctat agtctaactc tcatagaaat ctcacgcaaa
    10921 gatatcgctc cgcagaatat aaccgataac atctccctta cgtacggtag cgccttgttg
    10981 tgcacatatt tccaccacac gtccggtaaa tccggtcaga atcttttcat attctcccca
    11041 tggagtagaa aggtagcaaa agacttcgtc atgctgatat ttacgtccga tgaatggcgc
    11101 aatggatggt ccctctacgg aaacttccca aagtacctgc ccgttgtcgg gagcaataac
    11161 cggatccgcc ttggcacgtt tcaatttctt gatatcttcc tcggaataac cactctttgc
    11221 catggatgca tccttagcat gttgtaattc atcctcaaaa cgtttcttgg caacaccgga
    11281 cttataatcg cgatactgac gatcgtgcat agccagttca aaaagttctt cgtcatcctc
    11341 tccatactcc cagccattct catccatttc cttgcgataa tcatccaaag catccggata
    11401 attcaactgc ggatcagtat cgacaaactc atatccttta gacttcgcca attctataat
    11461 ctccggagca agcgtacccg gcagacgtcc actcttaccc agaatcatat cccaggtatg
    11521 gttgtctatc attgtccagc gctcttcccc ttttaccaat tgcataagat tcatcaatgc
    11581 aacattcttc acatactgac tgaaaggagt caccaaagga ggataaccca acttaggcca
    11641 cacatattcc acttcgtcga aaagcattac cagcaaatcg tcaagactaa gttcaggttc
    11701 gttcttactc cgtaatatca tattgatacc ggaatgtacc cctttcaaat ctgccatcat
    11761 agaacccatc ataccacccg gcaaaccaca tttcaataaa agcgaagaca tatatttgtt
    11821 ggtaggatcc atgaagtaac ccaaaaagtc atctatgaat tcctgcgtca tcgcacgagc
    11881 cttcatatat gctttcatat taatatcggg aacctgaaaa cctaaatctt tcaacattgc
    11941 ctgtaccgag atcacgtccg gatgcacttt accccaagac atgggctcca tagccacatc
    12001 aataatatcc gcaccattct cgcaaacctc gagaatagat gccatagaca atcccggtcc
    12061 gctatgacca tgatattgta tcaatacatc cggatgtttt tccttgatag tcctgaccaa
    12121 ttgccccaac atacccgggc gaccgatacc tgccatatct ttcaaacata tttcaggtgc
    12181 accggcctca atcagttgat cggcaattcg ggcataatac tcaacggtat gcaccggaga
    12241 atatgtgatg caaagagtcg cctgcggaat catacccgct tccagagcat atttaatgga
    12301 gggaattatg tttctcgtct cattcagtcc acagaagata cgggtgatat ccaccccttg
    12361 tgcatgcttg actttataca tcaatttacg cacatctgcc ggaaccggat acatacgcaa
    12421 tgcattcaaa ccacgatcga gcatatgcgt ttgaatgccc gcttctctaa aaggtgcggt
    12481 aaaagcacgg acggctttat taggattttc gccgtacaat agattcactt gctcaaaagc
    12541 acctccattc gtttcaactc ttgtaaaaca gcccatctca acaatcaatg gagctatacg
    12601 tacaagctgg tcaacccgag gttgatactt accggaagat tgccacatat cccgataaac
    12661 aagactgaat ttgatttcct ttttcatcat agccaataat aagtgatttt tttctttggt
    12721 taacttcaca tatacaaata taaaggtttg ttttgacata tagtcaaaaa tagcctttaa
    12781 aaaatgggta aatagagatg ttttacatca taatgaaagc aaacaatgcc tacactcttc
    12841 caattataat aaataacaaa tcaaattgtc taatgttcag atatatcccc ttaagaatcc
    12901 aaaggcttca cgaagtttat tcatactaag gtttgcacga atgcaaatcg cttttcaaag
    12961 tcatcattcg gcataaaaag ggtaagataa ccatcaggca taatccatct atcacgaagt
    13021 ttatcatatt caaaagtact attgcaataa ttaatataag atgttacatt agtggagtca
    13081 ttaagataaa gaatagattt attacagata tcattttcaa aaacacaaac taagacagca
    13141 ttgtccacta caatttcaat gcctttactt gcttcctctt taaacaagta ttcatatata
    13201 cacatctctt ttttaaaaaa caatctttga atgcggctac ttgtattagt gagcacgctt
    13261 cttcccacat acagcaaatt ttcaaagtgt gaatgcaatt taagagtatc catttcatca
    13321 tttttttatt gttattactt tgctaaatat tttatgactg atctctctca tttaagattc
    13381 ttgatttgcc agacataatt tattctccaa agtaacatat tcacattcat atactcacaa
    13441 tcatatatga ttgtatgata agtttcaatt aaaataaaga attacaagaa gaaacatcta
    13501 cccattcaag gttacacaaa taaagatgaa atgagactgt ctttaataat gtagtgatta
    13561 ttaaccaaac acacaaggat ttcgtatatt tctcatttca gtacaccgaa aaaagtttat
    13621 cttttctgta taaacgactt ttgagtttct aataaattct caaggagttt attagaaacg
    13681 gtatccaagt ttattaaaaa cccgaatgta gctttcagaa gggtatacat tgaatttatg
    13741 caacaaaaaa ggctgcaaat cctataaaag gttgcagcct caagcttttt atcgggtcgt
    13801 ctatacccta atcctcataa ggatctccta gatgttttgt tataatctta tactgtttca
    13861 tcgtcagata acgatgatta tacggcatat aaccggtcgg tacaagttct ttggtcaacg
    13921 ggttacagtc tttaatccat cggcttagac aacgcactgc atttttactg gtcgtacatc
    13981 cggggaagta caatgcagct aatacagcaa aagataagat tcgtctcatt tcgtttttaa
    14041 agttttaatt tgtcgtttca ttgtttcttt cgttatacaa atatacaaca tcaaaaagcg
    14101 tttgtcaagt cttttgggct tttgccgtta atataaagga ttatttatcc atacaaagct
    14161 gattttcaat caattaagct atcattttat tttttcaata tttgacatta aaattattgc
    14221 aaagcactta aaataaagca atatctttcc tttaaaagga acaccccatt ggttttaaag
    14281 gaacgatgcc ttggttttaa accaacgggg cgttcctttt aaaccaagaa aacacttata
    14341 ttcagacctt attttctaat tttcctagaa gctgcaatag tattcaggaa gacttacttt
    14401 cctccccatt acttacccca aaagcattct actttagcca ttaagagtgc atcgtgtacg
    14461 ataacagtga aaatcagtga aagaatttaa aagagaaaca aatacaacag aattatttgg
    14521 aggttagttt gcaaagacat acatttgtca tgtgattttt ttcatagtat tagatttaag
    14581 gttaacaaag gttggagcaa ggcgttgctc ctttttttat atccatatat gaggttagtt
    14641 tatacgagtt aattcaataa ctgatacatt cctcctgcca atacacgaac tactcctttc
    14701 atttccagtt caaaaagaat agcatttatt ttatgtacgg gaatatctgc ttctactacc
    14761 agagaattaa tctgtaaatt cccctgtttc tccaggatag agacaatctt ctgttcttct
    14821 tcggacaagt cgagaaaaag actacgttgc acatttactt tctcggaaga agttgccggt
    14881 atattccatc ccattgcctg tacaagatct tcagccgata atagtaagga agccttatta
    14941 tccctaatca atcgattaca tccctttgaa tattcatcat ttatccggcc gggaaaagca
    15001 aaacaatcac ggtgataact ttcagcaagt tcagcagtga ttaatgagcc tcctttttct
    15061 gccgattcaa tgacaactgt agcatcacac atacctgcga caatacggtt acgactgacg
    15121 aaattatgtt tgtcgggatt cgtaccggac agaaattcag tcaatagtcc tcctttttcg
    15181 agcatatcaa tggctgtttt tcga
//
