LOCUS       c00038_gnlPro..        16286 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PGINHKKM_38.
ACCESSION   c00038_gnlPro..
VERSION     c00038_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 14:14:39
            Original ID  :: gnl|Prokka|PGINHKKM_38
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16286
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16286
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2734:6286](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2735..6286
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16286
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16286
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             complement(2..67)
                     /locus_tag="ctg38_1"
                     /transl_table=11
                     /translation="MKQVITCHVCTVLDLVDNFACY"
     CDS             complement(162..1289)
                     /locus_tag="ctg38_2"
                     /transl_table=11
                     /translation="MAPASARQMASELALLPMWYAEEGSVVLAPSAYNLDYVKKIQELL
                     GLSVDLMTEPELASERNLDIRPWGWDIAIRKRLLDLGVEESELPSIEQLDKLRFCSHRS
                     CAVGLLPQLQLGACFCGESFYLTFPEEWKSFVESHDTCLLKAPLSGSGKGLNWCKGVYT
                     PSISGWCSRIGNQQGGVIGEPLYNKVEDFAMEFRSSGNGRFGFAGYSQFRTGGSGAYEG
                     NLLISDAAIERNLSEYIPVEEIYKLRDRLEQELSLRFGTIYNGYLGVDMMICRFPESPV
                     YRIHPCVEINLRMNMGVVARHIYDHYIYPTSTGAFQISYYPTEGTAWRAHKEMEEAYPL
                     EIEQGRIKSGYLSLVPAHKKSSYRAWVFISKSVFL"
     CDS             1524..2702
                     /locus_tag="ctg38_3"
                     /transl_table=11
                     /translation="MESFYRTHAYLVEHTNAPVRRDLMDEIDWSDRLIGIKGTRGVGKT
                     TFLLQYAKEKFGNDRSCLFINMNNFYFSGHSIVDFANEFQKRGGKVLLIDQVFKHPEWS
                     RELRMCYDRFPNLKIVFTGSSVMRLKEENLELRDIAKSYNLRGFSFREYLNLQTGMKFR
                     AYSLEEILSTHEQIAKGVLSKVRPLDYFQDYLHHGFYPFFLEKRNFSENLLKTMNMMVE
                     VDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDIQTSRATVMNYIKYLADAR
                     LINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVLDTFFANSLWKDHKVHKGD
                     KNVSFMVDEVMPFKICQEGAKIKNNLNVTYALHKAEIGRGNQIPLWMFGFLY"
     CDS             2735..6286
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg38_4"
                     /sec_met_domain="PFOR_II (E-value: 1.4e-18, bitscore: 57.9,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 1.7e-82, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 1.7e-31, bitscore: 100.4,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.7e-12, bitscore:
                     38.2, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 5.8e-12, bitscore: 37.3,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 9.2e-09, bitscore: 26.0,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 4.6e-05, bitscore: 14.8,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 2.8e-25, bitscore: 78.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMNPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDHLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKTIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQILSVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDTPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIALEIGLGNRTNTILQSAFFRITGVIPV
                     DQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLAVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTSKYEKRGVAAFVPEWNPENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKVFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAEADNWTYCAENVKTKQHLVDIKSNVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTTNENGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARIVKLFNQILEGDNAPAEAKEVLKAWIENMYDADKTKE
                     LAPQIEAIIEQGIAAGCPVSKELKGLTQYLVKRSQWIIGGDGASYDIGYGGLDHVIASG
                     KDVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQI
                     AMGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLW
                     RYNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPTEAEELFKAAEENAK
                     WRYNSYKRLARENWGAE"
     CDS             complement(6439..7305)
                     /locus_tag="ctg38_5"
                     /transl_table=11
                     /translation="MRIYKIVGIVLSAMLLLASCTNSDLEKKKVKIAYANWLEGIAMSH
                     LAKVVLEEHGYEVELQNADLAPIFVSMSGKKSDVFLDAWLPITMKDYMDQYGDSIEFLG
                     EVYGEARVGLVVPQYVTIQSISELEANKDRFSSEIVGIDAGAGIMKTTDKAIAAYGLDG
                     YTLMTSSSSTMLASLKKAMDKGEWMVITGWTPHWMFDLFYLKFLDDPKKVYGDLEEIHA
                     IAWKGFSEKDPFAAEFFGNIKLTTEELSSFMTAMKDARMDEEEIARKWRDEHRLLVDSW
                     IPKSENK"
     CDS             complement(7326..8150)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 92.9; E-value: 6.9e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg38_6"
                     /sec_met_domain="BPD_transp_1 (E-value: 2.9e-29, bitscore:
                     92.9, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIEMAINWMMIHFSTFFDAVNAGIGSFIIGFQHILFGIP
                     FYITILVLAALAWMKAGRGTAIFTALGLLLIYGMGFWEATMQTLALVFSSTCLALIVGV
                     PLGVWTANSSRAEKILRPVLDLMQTMPAFVYLIPAVLFFGLGAVPGVFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATRWQLLYKVQLPLALPTILTGVNQTIMMSLSMVVIA
                     AMIAAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIILDRITQGMAGRKNKN"
     CDS             complement(8147..9373)
                     /locus_tag="ctg38_7"
                     /transl_table=11
                     /translation="MSKIEIKDLYLIFGNEKQKALKMLKKDKSKEEILKDTGCTVGVKD
                     ANLSINEGEFFVIMGLSGSGKSTLLRCINRLIRPTTGQVLVNGVDISKISEKELLQVRR
                     KELAMVFQNFGLLPHRSVLSNIAFGLELQGVKKEEREKKAMESMKLVGLKGYENQMVGE
                     LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLALQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEVVQVGTSEEILTEPANDYVARFVENVDRSKIITASSLMID
                     KPLVARLKKEGPEVLIRKMRAKNITVLPVIDADDKLVGEVRLNDLLKLRSKQEKSIETI
                     VRTEVHSVLEDTVLEDILPLMTKSNSPVWVIDETREFLGTIPLSSLIIEVTGKDKEEIN
                     EIIQNAIDL"
     CDS             complement(9672..10010)
                     /locus_tag="ctg38_8"
                     /transl_table=11
                     /translation="MKDYKVDKASLSASFCQEVYQVVREIPVGKVSTYGGIAALLGMSQ
                     CSRMVGRALKQIPDDLSAPCHRVVNASGRLVPGWTEQKQLLLEEGISFKQNGCVDLKKH
                     LWNYSVPE"
     CDS             10094..11389
                     /locus_tag="ctg38_9"
                     /transl_table=11
                     /translation="MQLYLLYLQIIPTFVPIKSNPIINKTSTAVMKKKTILFASCLLGA
                     LAFSSCEKNLYDESKQPEKEKKMTDLEVPADFDWKGSQNAKVKIASQSTATISVFLEEN
                     CNEEALMLRMDVDANTSKLELPIEIPAYIKNVYVKYGNGSEIQTVPVESNGTISIVVPA
                     NATALSRVTTRANKEVETNNIFNYPGYGNGTIMFEDMYPALGDYDFNDFVAWYNFQIDG
                     FYWSHNQCYAEYLMIGFQIRAIGGIYDYNLYIRLAEVQYNELDLEETQMYLERNNPEEA
                     ENIKILKGPKGELIISLKKPAIPNGYKYYNTEVNEKTKPKKMMAIYLVFNSPVNVKSLQ
                     DSKMDFYIAKTNKGQEIHLKGYSPVYYNSNESYVNEDNFIWGLKVPASLHHAREEVNFL
                     EAYPDFEQWVTSGGQENQRWWNKPKTNKLIMN"
     CDS             complement(11531..14413)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 62.8; E-value: 1.2e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg38_10"
                     /sec_met_domain="Peripla_BP_1 (E-value: 5e-20, bitscore:
                     62.8, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEAMKYMKWITVLFCLLGLAACRQDAPRFRIGVAQCSDDSWRHK
                     MNDEILREAMFYDGVSVEIRSAADDNRKQAEDVHYFIDKGVDLLIISANEAAPMTPIVE
                     EAYQKGIPVILVDRKILSDKYTAYIGADNYEIGRAVGNYIASSLKGKGNVVELTGLGGS
                     TPAMERHQGFMAAISNYPDIKLIDKADAAWEREPAEVEMDSMLRRHPKIDAVYAHNDRI
                     APGAYQAAKKAGREKEMIFVGIDALPGKGNGLELVLDNVLDATFIYPTNGDKVMQLAMN
                     ILEKKSYPRETVMNTAVVDRTNAHVMQLQTTHISELDQKIETLNGRIGGYLSRVATQQV
                     VMYGGLVILLLVAGLLLVVYKSLRSKNRLNKELSEQKKQVEQQRDKLEEQRDILEEQRD
                     KLEEQRDQLIQLSHQLEEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADSSLSEDQR
                     RMLLLVQRNVNILLRLVNQILDFRKYENGKMEYTPISLDILSSFEGWNESFMAAARKKH
                     IHFSFDYMPDTDYRTLADVEKLERIYFNLLSNAFKFTPENGKVTVRLSSLTKDDHCWIR
                     FTVANTGSMISAEHIRNIFDRFYKIDMHHAGSGIGLALVKAFVELHKGTITVESDEKQG
                     TIFTVDLPVQTCETVVSENSPAFSVPATSVTSTDAATSAVAGAPVTPATSGYSGSSSLN
                     DALTYEEEELEKSYDSSKPCVLIIDDNADIRLYVHGLLHTDYTVIEAAYGSEGIRKAMK
                     YVPDLIISDVMMPGMDGIECCRRLKSELQTCHIPVILLTACSLDEQRIQGYDGGADSYI
                     SKPFSSQLLLARVRNLIDSHRRLKQFFGDGQTLAKEDVCDMDKDFVEKFKALIEAKMGD
                     SNLNVEDLGKDMGLSRVQLYRKIKSLTNYSPNELLRIARLKKAASLLASSDMTVAEIGY
                     EVGFSSPSYFTKCYREQFGESPTDLLKRKG"
ORIGIN
        1 tataacaagc gaagttgtca actaaatcca gtacagtaca cacatggcat gtgattactt
       61 gtttcatgca ataaaacttt ttgtttctcg gtgtggaacc aatggtttca ctacatgaaa
      121 ctatcagttt cacaccgaga aaccataact tcgatataat atcacaaaaa cacgcttttt
      181 gagataaaca cccacgcccg ataactactc tttttatgag ccggcaccaa tgacaaatag
      241 cctgatttta ttcttccttg ttctatttcc aaaggataag cctcctccat ttctttgtgt
      301 gctctccagg ctgttccttc cgtagggtaa tagcttattt gaaaagctcc tgttgaagta
      361 ggatagatat aatggtcata aatatgacgc gctactactc ccatattcat cctcaagttg
      421 atttccacgc aaggatgaat ccgataaaca ggagattctg gaaagcgaca gatcatcata
      481 tccactccca aataaccatt ataaatggtt ccgaaacgga gggataattc ttgttcaagg
      541 cggtcgcgca atttataaat ttcttcgaca gggatatatt ccgaaagatt ccgttcgatg
      601 gctgcatctg aaatcagcag attaccttcg tacgccccac ttccacccgt acggaattga
      661 gagtatccgg caaaaccaaa tcgaccatta cccgaagaac gaaattccat agcaaaatct
      721 tccaccttat tatatagagg ttcgccaata acacctcctt gctggttgcc aatgcgtgag
      781 caccaaccgg aaatggaagg agtatataca cctttgcacc aattcaaccc ttttccgcta
      841 ccggataaag gagctttcag taaacaagta tcatgtgatt ctacaaatga cttccattct
      901 tcgggaaacg tcaggtaaaa agactctcca caaaaacagg ctcccagttg tagctgtggt
      961 aataatccca cagcacagga acgatgggaa cagaaacgca gtttatccaa ttgctcaata
     1021 gaaggaagct cgctttcttc cactcccaaa tccaacagtc gttttcttat tgctatatcc
     1081 cagccccaag gacgaatatc caaattccgc tccgaagcaa gttcaggttc tgtcatcaaa
     1141 tcaaccgaaa gtcctaataa ttcctgtatc ttcttcacat agtcgagatt ataagcggaa
     1201 ggagccaata caacacttcc ctcttctgca taccacatcg gcaacaaagc caattcggat
     1261 gccatctgcc gggcggaagc cggtgccata tagtttgttt caccgctggc taacgccaaa
     1321 tcatgttccg gattgaatat ataaagagcc ttttttgtca ttttaaacga attcaaaact
     1381 ttattctgca aatatataca ggaaatagtc aggaatggct acaataaaca gaaagttcta
     1441 attaaactca caattttgcc atctctactt tgcaaatcct aaaaaaagca gtatatttgc
     1501 cacccgaaaa acaaagaact gaaatggaat cattctatcg cacacacgcc tacctcgttg
     1561 agcacaccaa tgcccccgtt cgccgcgatc ttatggacga gatcgactgg agcgaccgcc
     1621 tgattggtat caaagggaca cgtggcgtag gaaaaaccac tttccttctc caatacgcca
     1681 aagaaaaatt tgggaacgac cgctcctgcc tgttcatcaa catgaacaac ttctacttct
     1741 ctggccacag cattgtagac tttgctaacg aattccagaa acgtggtgga aaagtattgt
     1801 tgatcgacca agtgttcaaa cacccggaat ggagcagaga gttgcgcatg tgttacgacc
     1861 gttttcctaa tttgaaaatt gtctttaccg gctcatctgt aatgcgactg aaagaggaaa
     1921 atcttgaatt gcgtgatatt gcaaaaagct ataacctgcg cggattttct ttccgcgaat
     1981 acctgaactt acaaacaggc atgaaattca gggcctacag tctcgaagaa attcttagca
     2041 ctcacgaaca gattgccaaa ggagtactct ctaaagttcg tccgctggat tacttccagg
     2101 attacctgca tcatgggttc tatccattct tcctcgagaa gcgtaacttt tcggagaatt
     2161 tgctgaaaac gatgaacatg atggtggaag tagatatcct gctcatcaaa caaattgaac
     2221 tgaaatatct ttcaaagata aaaaaattac tatatttgct cgctgtcgac ggaccgaagg
     2281 ctcccaatgt gagtcaactg gcaagcgaca tacagacatc tcgcgccacg gtgatgaact
     2341 atatcaagta tctggcagat gcgcgactca ttaatctggt ttatccgaaa ggagaagaat
     2401 ttcctaaaaa accttccaag ataatgatgc acaactccaa cctgatgtat tccatctatc
     2461 ctgtgaaagt ggaggagcag gatgtactcg acacattctt tgcaaattct ttatggaaag
     2521 accataaggt acataaagga gataaaaacg tctcttttat ggtggacgaa gtaatgccgt
     2581 tcaaaatttg ccaggaagga gcaaagatca agaacaatct gaatgtgacg tacgcgttgc
     2641 ataaggctga aataggtcgg ggcaaccaga tacctctctg gatgttcggc tttttatatt
     2701 aaaagattta tttacttaaa tatttaattt agttatgact aaacagaaga aattcatcac
     2761 ttgtgatggt aaccaggctg cagcgcatat ctcgtatatg ttctctgaag tagctgctat
     2821 ctaccccatc actccttctt cgactatggc tgagtacgta gacgaatggg ctgccgcagg
     2881 acgtaagaac atcttcggcg aaacagtatt ggtacaggaa atgcaatctg aaggtggtgc
     2941 tgccggtgca gttcacggtt ctcttcaggc tggtgcgttg actactactt acactgcttc
     3001 tcaggggctt ctcctgatga tccctaatat gtacaaaatt gccggtgagt tcttgccttg
     3061 cgtattccat gtatctgctc gtacattggc ttctcacgca ttgtgtatct tcggtgacca
     3121 ccaagacgta atgtcagctc gtcagactgg ctttgcgatg ttggctgaag gctctgtaca
     3181 ggaagttatg gatttggctg gtgttgctca cttggctacc atcaaatctc gcgttccgtt
     3241 catgaacttc ttcgatggtt tccgtacatc tcacgaaatc cagaagattg aaatgttgga
     3301 aaatgatgat cttgctccgc tgatcgatca ggaagctttg gctgaattcc gtgcccgcgc
     3361 actgaatccg atgaatccgg ttgctcgtgg tatggctgaa aaccccgacc acttcttcca
     3421 acatcgtgaa tcatgtaaca actactatga agcagttcct gctatcgtag aagaatacat
     3481 gaatgaaatt tctaagatta caggtcgtaa atacggtttg ttcgattatt atggtgcaga
     3541 agatgcagaa cgcgtaatta tcgctatggg ttctgtaaca gaagctgccc gcgaagctat
     3601 cgaccacttg gtagcaaatg gcgaaaaagt gggtatggtt gccgtacacc tgtatcgtcc
     3661 gttctctgct aaacacttcc tggctgctgt acctaagact gccaagacta tcgcagttct
     3721 tgaccgtact aaagaaccgg gcgctaacgg cgaacctctt taccttgacg ttaaagactg
     3781 cttctacggc gcagaaaatg ctccggttat cgttggcggt cgctacggtt tgggttcaaa
     3841 agatactact cctgctcaaa ttctttcagt attcgaaaac ttggccatgc caatgccgaa
     3901 gaatcacttc actatcggta tcgtagacga cgttactttc acttctcttc ctcaaaaaga
     3961 agaaatcgct ttaggcggtg aaggaatgtt cgaagctaaa ttctacggtt tgggtgctga
     4021 cggtacagta ggtgctaaca agaactctgt aaagattatc ggtgacaaca ctgacaaaca
     4081 ctgccaggct tacttctctt atgactctaa gaagtcaggt ggtttcactt gttctcactt
     4141 gcgtttcggt gatactccga tccgttccac ttatttggta aatactccga acttcgttgc
     4201 ttgtcacgtt caggcttacc tgcacatgta cgatgtaact cgtggtttgc gtaagaacgg
     4261 ttctttcttg ctgaacacta tctgggaagg tgaagaactg gctaagaacc tgcctaacaa
     4321 ggttaagaaa tattttgcac agaacaacat ttccgtatac tatatcaacg caacacagat
     4381 tgcattggaa attggtttgg gtaatcgtac caacactatc cttcaatctg cattcttccg
     4441 tatcacaggt gttattcctg tagaccaggc tgttgaacag atgaagaaat tcatcgttaa
     4501 gtcttacggt aagaagggtg aagacgttgt taacaagaac tatgctgccg ttgaccgtgg
     4561 tggtgaatac aagactttag ctgttgatcc tgcttgggct aacctgccgg atgatgcaaa
     4621 agctgaaaac aacgatcctg cattcatcaa cgaagtagtt cgtccgatca atgcacaaga
     4681 tggtgacttg ctgcctgtat ctgcattcaa gggtatcgaa gacggtactt ggtatcaagg
     4741 tacttctaaa tacgaaaaac gtggtgtagc cgcattcgtt cctgaatgga atccagaaaa
     4801 ctgtatccag tgtaacaagt gtgcatacgt ttgtcctcac gcttctatcc gtccgttcgt
     4861 actcgatgct gaagagcaga agggtgctaa gttcgaacaa ttgaaagcag taggtaaagt
     4921 attcgacggt atgacattcc gtatccaggt tgacgttctc gactgtctgg gttgcggtaa
     4981 ctgtgctgac atctgtccgg gtaatccgaa gaagggtggc aaagcattga caatgaaaca
     5041 cctcgaaagc caattggctg aagctgacaa ctggacttac tgtgctgaaa acgtgaagac
     5101 taaacaacat cttgttgata tcaagtctaa cgtgaagaac tcacagttcg ctactccgtt
     5161 gtttgagttc tctggtgctt gctctggttg tggtgaaact ccgtatgtga aattgatttc
     5221 tcaattgttc ggtgaccgtg aaatggttgc taacgctacc ggatgttctt ctatctactc
     5281 tggttcagtt ccttctactc cgtatactac gaacgaaaac ggtcacggtc ctgcttgggc
     5341 taactcactg ttcgaagact tctgtgaatt cggtctgggt atggaattgg ctaacgaaaa
     5401 gatgcgtgct cgtatcgtga agttattcaa ccagattttg gaaggcgata acgctcctgc
     5461 tgaagctaaa gaagtattga aggcatggat tgaaaacatg tacgatgctg acaagacaaa
     5521 agaattggct cctcaaatcg aagctatcat cgaacaaggt atcgctgccg gatgtcctgt
     5581 tagcaaagaa ctgaaaggtc tgactcaata tcttgtaaaa cgcagccagt ggatcattgg
     5641 tggtgacggt gcttcttacg atatcggtta cggtggtctt gaccatgtaa tcgcttccgg
     5701 taaggacgtt aacattctcg ttctggatac tgaagtttac tctaacacag gtggtcagtc
     5761 ttctaaagct actccggtag gtgctatcgc taagttcgct gctgctggta agcgcgtacg
     5821 taagaaagac ctcggtctga tggctactac ttacggttat gtatatgttg cacagatcgc
     5881 tatgggtgct gaccaagctc aaactctgaa agctatccgt gaagctgaag catatccggg
     5941 accatctttg attatcgctt acgctccatg tatcaaccac ggtctgaaag caggtatggg
     6001 taagagccag gaagaagaag aaaaagctgt taagtgcggt tactggcact tgtggcgtta
     6061 caacccagct ttggaagaag aaggcaagaa cccattccaa ttggatagca aagaaccgaa
     6121 ctgggaagat ttccaaggtt tcttgaaggg tgaagttcgt tacgcttctg taatgaaaca
     6181 atatcctact gaagctgaag aactgtttaa agctgctgaa gaaaacgcta aatggcgtta
     6241 caacagctac aaacgtttgg ctagagaaaa ctggggtgct gaataatagt aataccctat
     6301 aaatataaag cggtaatctt tgataagatt accgcttttt tattgtatga actctgtcca
     6361 acataaacag tactcccttt ttcccactag agttcatgtc tattttatat ttaaaattaa
     6421 aaataacaat gctccaatct atttattctc tgacttcgga atccaactat ccaccaacag
     6481 ccgatgctca tccctccatt tgcgggctat ttcttcttca tccatccggg catccttcat
     6541 agctgtcata aaagagctaa gttcttctgt cgttagtttg atgttgccaa agaattcggc
     6601 agcaaacgga tctttctcac tgaatccttt ccatgcaata gcatgtattt cttccaagtc
     6661 tccatatact ttcttcggat catccaagaa tttcaaataa aacaggtcaa acatccaatg
     6721 tggtgtccac cccgtgatga ccatccattc tcctttatcc atcgcttttt tcaaagaagc
     6781 cagcatggtg gaactacttg aagtcatgag ggtataccca tcaagtccgt aagcagcaat
     6841 ggccttatcg gtcgtcttca ttatccctgc tcccgcatca attcctacta tttcagaaga
     6901 gaaacggtct ttattagctt ccagctcact aatagactgg atcgtaacat attgaggaac
     6961 aactagtcct acacgggcct ctccatatac ctcacccaga aattcgatac tgtctccata
     7021 ctgatccata taatctttca tcgttattgg taaccatgca tccagaaaca catctgattt
     7081 ctttcctgac atagatacaa aaataggggc aagatcagca ttttgcaatt caacctcata
     7141 tccatgctct tccaatacca ccttagccaa atgactcatg gcaatacctt ccagccaatt
     7201 ggcataggct atttttactt tctttttctc taagtctgaa ttagtacagg aagctagcaa
     7261 aagcatagct gacaatacta ttcctactat tttatatatt ctcatacgta ttttatcctt
     7321 tccgtttagt tcttattttt tcgtcctgcc attccttgcg tgatacggtc taagatgata
     7381 gctaaaataa caactgctat accaccttca aacccaagtc cgattttcat ttgggtaata
     7441 cctttcaata caatttctcc cagaccaccg gcagcaatca tggcagcaat tacaaccata
     7501 gaaagcgaca tcattattgt ctggttgaca ccagtcagaa tggtgggcaa cgccaaagga
     7561 agctgcactt tatacaataa ctgccaacgg gtagctccga acgaacggga agcttccact
     7621 acatttttag gaacttgccg gattcccaat ccggtaaggc ggaccacagg aggcatagca
     7681 aagataatgg tggcaaacac tcctggcact gctcccaatc cgaaaaacaa aacagcagga
     7741 atcagataaa caaaagcagg catcgtctgc atcaagtcga gaacaggacg gagtattttc
     7801 tctgcacgcg aactgtttgc cgtccatact cctaaaggta caccaacaat cagggccaga
     7861 caggtagatg aaaaaacgag agctagagtt tgcatggtag cctcccagaa tcccattcca
     7921 tagatcagta ataatcccaa tgcggtgaaa attgccgtac cgcgtcctgc tttcatccat
     7981 gcgagtgcag caagtaccaa aatggttata taaaaaggta ttccgaaaag tatgtgttgg
     8041 aatcctataa taaaactacc gatgcccgca ttcacggcat caaagaaagt ggaaaaatgt
     8101 atcatcatcc aattgatggc catctctata tattgtccta tatttatcat aaatctattg
     8161 cgttttgaat tatttcgttt atttcttctt tatctttccc ggtcacttcg atgattaagg
     8221 atgaaagcgg gattgttcct aaaaactcgc gcgtctcatc aatcacccat accggcgaat
     8281 tgctctttgt cattagagga agtatatcct ccaacaccgt atcctccaac acagaatgta
     8341 cttctgtacg cacaatcgtt tcaatggatt tttcctgttt gctacgtaac ttaagcaagt
     8401 cgttcagacg tacttctccg accagtttat catcggcgtc tatgacaggt aatacggtga
     8461 tattcttcgc acgcatctta cgaatcaata cttcgggacc ttctttcttc agacgggcca
     8521 ccaacggttt gtcaatcatt aaagaagagg cggtaataat tttgctccta tccacgtttt
     8581 caacaaaacg ggctacataa tcgttagccg gttcagtcag gatttcctcc gaagtaccta
     8641 cctgcaccac ttctccgtct ttcatgatgg caatacggtc acctagctta attgcttcac
     8701 tcaagtcgtg ggtaataaaa acaatcgtct ttttcatctt tgattgcaag gccagtagtt
     8761 catcctgcat ctgtacgcga atcagaggat cgagagcaga gaaagcctca tccattaaaa
     8821 gcacttcagg attattagcc agagcgcgag ccagtccgac acgctgttgc attccaccgg
     8881 aaagctcgcc taccatctga ttttcatatc ctttcaatcc gacaagcttc atgctttcca
     8941 tcgctttctt ctcacgttcc tctttcttca ctccctgaag ttcgaggccg aacgcgatat
     9001 tgctcaatac ggaacggtga ggtaacagac cgaaattctg gaaaaccatc gccagctctt
     9061 tccgacgaac ctgcaataat tctttttcgg aaattttaga tatatctact ccgtttacaa
     9121 gcacttgccc ggtagtagga cgtatcagac gattgataca acgcagtaat gtcgattttc
     9181 cacttcccga gagtcccatt atcacgaaaa actctccttc attaattgaa agattggcat
     9241 ctttcactcc taccgtacaa ccggtatctt tcagaatttc ctctttactc ttatcttttt
     9301 tcaacatctt gagggctttc tgcttctcgt taccaaagat aaggtacaaa tcctttattt
     9361 ctattttact catataatat attggtttag attataatat ttgttttgtt ttcaactgcc
     9421 gcattcctta ttctcactta cgataaacaa gttgaatgtt cgcatggttc agtcatgtca
     9481 catgataaca tgacggtccg acgtttttta aatggttaaa aaaaacagac agagtagttt
     9541 aaaaggaata gaatttgata agattatcct cttaatgaac agtagaaaac agtattttca
     9601 taaataaata acagtctgtt cttgcatatt gttggcacaa aggtaaggaa aatagattaa
     9661 atatgcaaat ttcattcagg tacggagtaa ttccaaagat gctttttcaa gtctacgcat
     9721 ccattttgtt tgaaagagat cccttcttcc aacaagagtt gtttctgctc tgtccaaccc
     9781 ggaacaagcc gtcccgacgc attgacaacc cgatgacaag gcgcagataa atcatccgga
     9841 atctgtttca aagcacgccc caccatacgg gaacattgag acattcccaa taatgcggca
     9901 attcccccat aggtagaaac tttacctacc ggaatttctc ggacaacctg atacacctct
     9961 tgacaaaagg atgcggaaag gctcgcctta tctactttat aatctttcat cactcaaaca
    10021 ttactttatt tcagttccaa aactagataa aaagaaaaga atttgcaaat aataaaagca
    10081 tttcaaataa aatatgcaac tttatttgct ttatttacaa ataatcccga cctttgtacc
    10141 cattaaaagc aaccctatta ttaacaaaac aagcactgct gttatgaaaa agaaaactat
    10201 cctgttcgct tcttgtttat tgggagcact ggctttcagc tcctgtgaga agaaccttta
    10261 tgatgaaagt aaacaacccg agaaagaaaa gaagatgact gacttggaag tacctgccga
    10321 tttcgactgg aaaggttctc aaaatgccaa agtgaaaatt gccagtcaat caactgctac
    10381 tatttctgta tttctagaag aaaattgcaa tgaagaggct ttgatgcttc gaatggatgt
    10441 cgatgccaac acatcaaaat tggaactccc aattgaaatt cctgcatata taaaaaatgt
    10501 gtatgtaaaa tatggtaatg gctctgaaat acaaactgtt cctgttgaaa gtaatggtac
    10561 tatttctata gtagtacctg ctaacgctac ggcattatcc agagttacca caagagctaa
    10621 taaagaagtt gaaacgaaca acatcttcaa ttatccggga tatggcaacg gaactattat
    10681 gttcgaagat atgtatccag ctttaggcga ttatgatttt aatgattttg ttgcatggta
    10741 taatttccaa attgacggtt tttattggag tcacaatcaa tgttatgcag aatacttaat
    10801 gataggattc caaatcagag ctataggagg tatatatgac tacaatcttt atatccgctt
    10861 ggcagaagta caatataatg aacttgattt agaagaaact caaatgtatc ttgagcgtaa
    10921 caatcctgaa gaggctgaaa atatcaaaat cctaaaaggc ccaaaagggg aattgattat
    10981 ttcactaaag aaaccggcca ttcctaacgg atacaagtat tataatacgg aggtaaatga
    11041 aaaaacaaag cctaaaaaaa tgatggccat ttacttggtg ttcaactcac ctgttaacgt
    11101 taaaagccta caagacagta aaatggactt ttatattgca aaaactaata aaggacaaga
    11161 aatccactta aaaggttata gcccggttta ttataacagc aacgaaagtt atgtaaatga
    11221 agacaacttt atatggggat taaaagtacc tgcatcttta catcatgcca gagaagaagt
    11281 aaacttcttg gaagcatatc cagactttga acaatgggta acatcgggag gtcaagagaa
    11341 ccaaagatgg tggaataagc caaaaacgaa taagttgatt atgaattaat aaatatacag
    11401 taaatcatat actgaattaa ataagaggta aggtatgtca atagatttcc ttacctctta
    11461 tttttatcat atgaattcca tagaagtata aacagataaa tgctcaccac caaattttgc
    11521 agattctatc ctatcctttc ctcttcaaca aatctgtcgg actctctcca aactgttctc
    11581 tataacattt agtaaaataa gaaggagaac taaaaccaac ttcataaccg atctctgcca
    11641 ctgtcatatc cgacgaggca agcagagagg cagctttctt caaacgagct atacgaagca
    11701 gttcattcgg agaataatta gtcagagatt taatcttgcg gtaaagttgc acacgactta
    11761 atcccatatc cttacccaaa tcttctacat tcaaatttga atctcccatc tttgcctcaa
    11821 tcagagcttt gaatttttcc acaaagtctt tatccatatc acagacatcc tctttcgcca
    11881 acgtttgtcc gtcaccaaaa aactgtttca ggcggcggtg tgaatctatc agattacgaa
    11941 cgcgtgccaa tagtaattgc gaactgaaag gcttggagat ataagaatct gcaccaccat
    12001 catacccttg aattcgttgt tcatccaaag aacaagctgt caataggata acaggaatat
    12061 gacaggtttg taattcgctt ttcaagcgac gacaacattc aattccatcc attccgggca
    12121 tcattacatc ggagataatc aagtccggga catatttcat agctttacga ataccttccg
    12181 agccgtatgc agcttctata acagtataat cagtgtgaag caatccatgc acatataagc
    12241 gaatatcagc gttatcatca ataatcagaa cgcaaggttt ggaagagtcg taactttttt
    12301 ccaattcctc ttcttcgtaa gttaaagcat cattcaagct cgaagaaccg gaataaccag
    12361 aagttgcagg agttacggga gccccagcaa cggcagaggt tgcagcatcg gtagaggtta
    12421 cagaagtagc aggcacagag aatgccggag agttttctga aacaacagtc tcgcaagtct
    12481 gtacaggcaa atcaacggta aagatagttc cttgcttttc atcactttcc accgtgatgg
    12541 tacctttatg caattccaca aaagccttta ccaatgccag tccaataccc gaaccggcat
    12601 ggtgcatatc tatcttatag aaacggtcga aaatattccg gatatgctcc gcagaaatca
    12661 ttgagccggt attggcaaca gtaaagcgaa tccaacaatg atcgtcttta gtcagggaag
    12721 ataagcgtac agttactttt ccattctctg gagtaaattt gaaagcgttg gaaaggaggt
    12781 tgaaatagat gcgttccaac ttttctacat ctgccaatgt gcggtaatcc gtatccggca
    12841 tataatcgaa tgagaaatga atatgtttct tccgggctgc tgccatgaaa gactcgttcc
    12901 atccctcaaa agaagaaaga atgtctaacg aaataggagt atattccatt tttccattct
    12961 cgtatttacg aaaatccaga atctgattga caagacgcaa gaggatattc acgtttcgct
    13021 gaactaacaa taacattcgg cgctgatctt cactcaaaga cgaatcagcc agtaaatgct
    13081 ctaccgggtc ggcaactaat gtcagtggag tacgaaaatc gtgagatata tttgtgaaga
    13141 aaaccagctt ggcatgagtc gcttcttcca gttgatgaga aagctggata agctgatccc
    13201 gctgttcttc gagtttgtca cgctgttctt caagaatatc ccgttgctct tcgagtttat
    13261 cgcgctgttg ctctacttgt ttcttctgtt cggacaactc tttattcagg cgattcttgg
    13321 aacggaggga tttatagact accaacaaca atcccgctac taataaaaga ataaccaagc
    13381 cgccatacat cacgacctgc tgcgtagcta cacgcgacag atacccaccg atacgtccgt
    13441 tcaatgtttc aatcttctga tccagttccg agatatgggt agtctgaagt tgcataacgt
    13501 gcgcgttcgt gcggtctaca acggcagtat tcatgaccgt ttcgcgagga taagacttct
    13561 tctcaagaat attcatggcc agttgcatca ctttgtcccc attagtcgga taaataaaag
    13621 ttgcatccag cacattgtca agcaccaatt caagcccgtt tcctttgccg ggcagggcat
    13681 caatgccaac aaaaatcatt tccttttcac gtccggcttt cttcgcagct tgataggctc
    13741 ccggagcgat acggtcgtta tgtgcatata ccgcatcaat cttcggatga cggcgaagca
    13801 tactatccat ttccacttct gccggttcac gttcccaggc agcatccgct ttatcaatca
    13861 gtttgatatc cggataattg ctgatagcag ccataaatcc ctgatggcgt tccatggcag
    13921 gggtggaacc acccagtccg gtaagctcca ctacattccc tttccctttc agacttgatg
    13981 cgatataatt tcctaccgca cgacctattt cataattatc ggcaccgata taggcagtat
    14041 atttatcaga aagtatcttc cggtctacaa gaatgacagg tattcctttc tgataggcct
    14101 cctccacaat tggagtcatg ggagccgctt cattggcgga aattatcagt aaatcaactc
    14161 ctttatctat aaaataatga acatcttccg cctgcttacg gttatcatcc gccgccgagc
    14221 ggatttcaac cgacactcca tcataaaaca tcgcttcgcg aagaatctca tcattcatct
    14281 tgtgccgcca agagtcatca ctacattggg ccaccccaat acggaaacga ggcgcatcct
    14341 gacgacaggc cgccaagccc aaaagacaaa acaagactgt tatccacttc atatatttca
    14401 tcgcttcaat cattcccttt ctttcgtata tcttttgtat ttctttctgt aatccaaatt
    14461 tctctccccg cattatttgc attcaccacc gggaaataca tcagttccac tttcacaggg
    14521 ttcagcgtgt attttccagt aaagcgtgaa agcaaaggaa ccgtaaactg ataagtacct
    14581 accggtaatt tttcgctaaa gataacagtt ttctctttaa aatactcacg atatacttca
    14641 gaacgggaga aattaacagg ttttgaggca taactacaac ctgccggaac aggaacttcg
    14701 agcatcacat attgcgcacc ctcctgtttc acctgcaagg taactgtcaa tgtaacaggt
    14761 acacccgcca ccaaagagtc tttttccaaa gtcgcctcca ccttgaaagc atcactctga
    14821 cgagcattca tcacacgctt cattgaatag acactataca ataaaggctc ttttcccgtt
    14881 tttgaaataa gcagactgtc gcctgctatc agccgggcat gataaggaaa ttccgtaatt
    14941 cgttgatgat ccttaccgct cacagacacc gacgttcctg acatccctcc ggaacctgcc
    15001 agcaaatcgg tcagaacagt tgccacagcc gaagaagcct gatacgtatt ccatccgcgc
    15061 tccttagtcc gcaaaatata caattgcata ttttctttca acttacacag ggaagggtca
    15121 tttttaataa tccggtaggc tatcaatgta tttatcatct gatttccctc ccaataataa
    15181 gtacgccgtc cgtcgtcaca gtaaacacct tccagcatat cctttttcag ataaggacgt
    15241 acgctatcac ccacattcac cgaatccacc tgttgcttga tttcccagag aagcagcttc
    15301 tctttcaagt atgaaagagg acgataatac ttgtttctat ttgccaacga gtcttctttc
    15361 tgttccaatt gccggacgaa aggttccaat aatctgactg ccgaagaata atccgcctct
    15421 actttccact catgcagagc atgaagtatt tctatatctt ccagtttcat tcctcgataa
    15481 ggacgcgtat gagcatactc cactttcaaa ccattcagat tcaactccac aggataacct
    15541 gcatcttgcg ccatcttcaa agcccgcaga atatgcgcag acatccagaa agaagtattt
    15601 tcagagttcc cccaccacga ccataactga tgtttgttct gatgattcgt cagtcgatgg
    15661 atgataggtc gaattgcttt atctactttc accttttcac ccttactctg catatactgt
    15721 tggtaagcca acaaaccgat taacttggat gccagctgct cattgcacaa atatttgtat
    15781 cctgtcaagt aattcactga ttctttatag atgtccaact gattgtcagt gatactcacc
    15841 atcacttctt catcctcgcc ggattgcact ttgaccgtct ttgcatcgga cagaataccc
    15901 aatgtgccct ccgccaattc agttccctgt ggcagtatcg gaatcgtata ttcctctcca
    15961 tcctgatagc catcgtcgcg agtgaaaaga tagctgatgg tcacgctatc ggcatgaact
    16021 gcctgcatcg gcactgtttc atgaaatccc tccatgaaac tcacttcctg ccgtttcaac
    16081 gtatccgttc cgacgcagaa ctgtgtcttt ccggctatgt gctgcccatc cagataattg
    16141 cggatagtcc caaccaccgt actctgatcc ccctccacca ggaagcgggg agttttcaac
    16201 tccgccatca acggtttgta agagcggatg gaacgtcgga aagtacccgt ctgcaaacga
    16261 cggttcatgc cataaacgac agtttc
//
