LOCUS       c00046_gnlPro..        16928 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IFNKLFLK_46.
ACCESSION   c00046_gnlPro..
VERSION     c00046_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 18:27:59
            Original ID  :: gnl|Prokka|IFNKLFLK_46
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16928
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16928
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3955:6928]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3956..6928
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..16928
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16928
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="1"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             complement(2..118)
                     /locus_tag="ctg46_1"
                     /transl_table=11
                     /translation="MSISYRVQGLSLKPWGIALKWLSLKPWGIALKFLFLHHE"
     CDS             683..3802
                     /locus_tag="ctg46_2"
                     /transl_table=11
                     /translation="MRSIFKVSILFLCLLTHSFLSAGNLPEKNIKHILIISAYADSNPW
                     SNSFITPIVTMASQDSTIGVYTINLKMFAVQKNSVNVEKFEEGICEKLPQYTPKMVVFI
                     GNASFVFCDNLNKIWPDIPMLLCGERDYTGPDSLIIEAHPLTPQQRIPISDLQKTMNLT
                     MMHAKLYMEENLQLMKQLIPQMKKVIYIADGTYMCQQNNYDLSTIIKEKYPELDYQLIS
                     AEDTSTDSLFAILNQQNPRTTGLIFSSWLRRKDYEDNLVMTTNSHRIIATSPVPLFSFR
                     KVGIQEEGGIVGGYIYNEKKYIDRMLKTIKDILHGQQPRYTPIYHAEDATPIFNYQSLI
                     QRNLDPKRCPGNTIFYNAPPTFWEKYEYTIIGIACLVILLLLFFQYHRVRVLEKMKRIQ
                     HKELESTGKYYNIINNMPILYMVEELIKNDDGRIVDTMYVDVNKHFEKKFFEKHQIIGK
                     RGSEIFPESLPQFLHFMNIALKEKRSITFSYYYKEIDTFYDVVVNASSDGRFMDVFCMD
                     STELHHAQMQMRSINHKLSMALDIANIIPWKWDLKTHTIHYDVNKALSNENQEINDEQL
                     SMSDEQYFAKIHAEDLSKVKEICTNFITGHCKKAKLEYRVLNNVNGAKRIDWIETQIAI
                     DSYDENGQPETLIGSSLTITDRKNMEIDLISAKNRAEESNRLKSAFLANMSHEIRTPLN
                     AIVGFSGILASTEEEEEKREYVSIIENNNTLLLQLISDILDLSKIEAGTMDFLYTDFEL
                     NKVMEELEQSLRLKLSPDREVTLTLTTPQPECYIHAERNRISQIIINLVTNAIKFTETG
                     SIHFGYEIREKEILYFYVTDTGCGISEDKQESVFGRFVKLNSFVQGTGLGLSICQTLIQ
                     QMGGEIGVHSKTGKGSTFWFTLPYHPTLQAPQQEVAEEPVKIKKQKICILVAEDHSSNY
                     RLIESILKKDYNLVHAWNGEEAVTLFKEHNPQLILMDINMPVMDGYEATKEIRKYSQRV
                     PIIAVTAFAYASDEQRVMENGFDAYMPKPINANQLKGQISSILMKHITFM"
     CDS             complement(3813..3953)
                     /locus_tag="ctg46_3"
                     /transl_table=11
                     /translation="MIKLEVVVILFFRAYKVTTFFHIISINMLYFMLFNIKYLDIAILW
                     K"
     CDS             3956..6184
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg46_4"
                     /sec_met_domain="Gly_radical (E-value: 4.2e-46, bitscore:
                     148.6, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate1 (E-value: 0.0, bitscore:
                     1172.7, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELNKIFKDGLWSTEINVRDFVSHNITPYYGDASFLEGPTERTKA
                     VWNRCLEALAEERANNGVRSLDNVTVSTITSHKAGYIDKENELIVGLQTDELLKRAIKP
                     FGGINVVSKACHENGVEVDDRVKDIFTHYRKTHNDGVFDVYTEEIRSFRSLGFLTGLPD
                     NYARGRIIGDYRRMALYGIDRLIEAKKEDLRNLTGPMTEARIRLREEVAEQIKALKDMK
                     VMGEYYGLDLSRPAYTAQEAVQWVYMAYLAAVKEQDGAAMSLGNVSSFLDIYMEYELSK
                     GTITESFAQELIDQFVIKLRMVRHLRMQSYNDIFAGDPTWVTESLGGRLNDGRTKVTKT
                     SFRFLQTLYNLGPSPEPNLTVLWSPELPEGFKEFCAKVSIDTSSIQYENDDLMREVRQS
                     DDYGIACCVSYQEIGKQIQFFGARCNLAKALLLAINGGRCENTGTVMVKNIPVLTSDTL
                     NFEEVMSNYKKVLTEIARVYNEAMNIIHYMHDKYYYEKAQMALVDTNPRINLAYGVAGL
                     SIALDSLSAIKYAKVTARRNDIGLTEGFDIQGEFPCFGNDNDKVDHLGVDLVYFFSEEL
                     KKLPVYKNARPTLSLLTITSNVMYGKKTGATPDGRAKGVAFAPGANPMHGRDKNGAIAS
                     LSSVAKLRYRDSQDGISNTFSIVPKSLGATEEDRVENLVTMMDGYFTKGAHHLNVNVLN
                     REMLYDAMEHPEKYPQLTIRVSGYAVNFVKLSREHQLEVISRSFHERM"
     CDS             6200..6928
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 74.1;
                     E-value: 4.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg46_5"
                     /sec_met_domain="Radical_SAM (E-value: 4.9e-28, bitscore:
                     91.2, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTINVHSYESMGTFDGPGLRLVVFLQGCNFRCLYCANPDTIAGKG
                     GTPTPPEEIVRMAMSQRPFFGKRGGVTFSGGEPTFQAKALVPIVRELKEKGIHVCIDSN
                     GGIWNEEVEELFKMTDLVLLDIKEFNPARHQALTGRSNEQTIHTAAWLEENEKPFWLRY
                     VLVPGYSDFEEDIRRLGEALGKYKMVQRVEILPYHTLGVHKYEAMEQEYKLKDVKENTP
                     EQLEKAAEVFKEYFTTVVVN"
     CDS             complement(6956..7399)
                     /locus_tag="ctg46_6"
                     /transl_table=11
                     /translation="MRKISLIVIHCSATRADRDFTAKDVDTAHRFRGFSCWGYHYYIRK
                     SGQIEPMRDEDTVGAHARGFNAISLGVCYEGGLDENGKAADTRTSRQKEAMHRLVSELL
                     QRYPDAKVVGHRDLSPDTNYNGIVDPWERIKECPCFEVKAETW"
     CDS             complement(7386..7577)
                     /locus_tag="ctg46_7"
                     /transl_table=11
                     /translation="MITLILDQMKEIVTKILDVIMFLVPFFGKRKRNRIVREVRFNATH
                     KEVCNVKTTEREKDDEKD"
     CDS             complement(7574..8077)
                     /locus_tag="ctg46_8"
                     /transl_table=11
                     /translation="MAMTVTYSVVPRKNPAKKDESAKYYAQAQASGELDFEELCEGITS
                     RSTCTETDVRAAISGILYEAKRALKAGRIVRLGDLGSLQIGLNSEGAVSVKEFSSSLIT
                     AAHIIFRPGKTLADITKILSYQQVTTRAVAQTGGSGNEGEDDDKGSGGGSDGGGSGEAP
                     DPAA"
     CDS             8271..8501
                     /locus_tag="ctg46_9"
                     /transl_table=11
                     /translation="MYYPDQPFHIRTYKKSELAHLYNPNVCLKVALQILRRWIVYNLPL
                     LQELEQEGYRARNRLLSPRQVATIIRYLGEP"
     CDS             8589..10706
                     /locus_tag="ctg46_10"
                     /transl_table=11
                     /translation="MEHFTIFQDFYRVIAEMTEEEIVSAISNGTYRETVEDVRRIFAEQ
                     GEKAANEKKIELPEITFSANYRGGRSNATLVKYLGYIVVDIDHQTQEALARILALAKKC
                     AHTRIAFISPKGMGLKIVVRVCRTDGTLPETIQEIEDFHHAAYHKIASFYAQLCGVEVD
                     TSGQDVSRTCLFSYDPDIYFNPDATAVIVEQPPMFFKSQKKKRASGKKKKTTAPDNNPL
                     TEQVALNYHSSHASLMVTLNYYHNKSEKYVTGNRNNYLHCLACMYNRYGVPQEEAAAFI
                     KSQFTDLPADEMDALIGSAYGHNEEFDTRKLNSTQKRILQIEQHIKENYDTRYNEVLHI
                     MEYRRRKTDTEQPEPFHILDEMMENSIWMEMNELGYSCTVKTIQNLIYSDFSSTYHPIR
                     EYLDSLPEWDGTDYIGILANSVHTSHQKFWVECLERYLVGMCAAATQDDVVNHTVLLLC
                     SEIQNIGKTTFINNLLPPELRAYLSTGLINPNNKDDLAKIAQAMLINLDEFEGMNGREL
                     NIFKDLVTRKVISIRLPYARRSQNFPHTASFAGTCNYQEVLHDTTGNRRFLCFHVNSME
                     FIKINYAQLYAQIKYLLNKPGYQYWFTQSENSRIEENNEDFIFHSPEEELVLTHIRKPE
                     RFEKVHYLTVTEIAELIRERTGYQYSHGTKAQLGKVMSKHGFEFHKGKNGRRYTVFIID
                     TEQVKSNRLYE"
     CDS             complement(10795..10926)
                     /locus_tag="ctg46_11"
                     /transl_table=11
                     /translation="MVGNLKKITVFFKFPTVFLRKKKEKVRVGEGKFLTFVFFFRRK"
     CDS             complement(10945..11247)
                     /locus_tag="ctg46_12"
                     /transl_table=11
                     /translation="MQINNHQIVDYDAVLDAKFGAEGTPERAEAEEKAYAFYTGQIIED
                     ARKKAKITQAELARRIGSDRSYISRVESGQTEPKVSTFYRIMNALGCRIEFSMSL"
     CDS             complement(11213..11575)
                     /locus_tag="ctg46_13"
                     /transl_table=11
                     /translation="LQYGKPQRNLRTYGGYVEAFMETLTEKEQDKIQYGLLLLKTQERL
                     STKFVKFVQDGVFELRTEYNGNIYRVFFIFDDGNIVVLFNGFQKKSQKTPGSEIDKALK
                     IKEEYYADKQSSNSRL"
     CDS             complement(11625..11870)
                     /locus_tag="ctg46_14"
                     /transl_table=11
                     /translation="MSHLTPVIIEYRGNPKQYVSVVLDAINLGRLTYDGVANCEQTFRA
                     LASVVDVISPKNGKTLSVETLVSYEKKKRAGEFEEK"
     CDS             complement(11879..12013)
                     /locus_tag="ctg46_15"
                     /transl_table=11
                     /translation="MENSLNDELLCSLKDELREVTAQINVHSEKLMDLLDQKKESSVN"
     CDS             complement(12140..13495)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1058:Major
                     facilitator family (Score: 157.1; E-value: 1.9e-48)"
                     /gene_kind="transport"
                     /locus_tag="ctg46_16"
                     /sec_met_domain="MFS_1 (E-value: 3e-48, bitscore: 157.1,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFKILDFYKISSPLAGGETDSEDSSRFKRIRWATFLSATTGYGI
                     YYVCRLSMNVVRKPIVEEGVFSETQLGIIGSCLFFVYAVGKLTNGFLADRSNVRRFMST
                     GLLCSALINLCLGFTSSFYAFALLWGLNGWFQSMGAASGVVSLTRWYSSKERGTFYGFW
                     SASHNLGEALTFISIALLVSWMGWRYGMIGAGIIGILGFFMMLVFMRDTPQSQGFLLNK
                     NSSSVDSHSLSGKQTEDFNKAQKAVLKNPAIWILALSSAFMYISRYAVNSWGVFYLEAQ
                     KGYSTLDASFIISISSICGIIGTVFSGIISDKMFSGSRNIPALVFGLMNVIALCLFLLV
                     PGVHFWIDVLAMVLFGLGIGVLICFLGGLMAVDIAPRNASGAALGVVGIASYIGAGLQD
                     VMSGILIEGQKTVQNGVDVYDFTYINWFWIGAALLSVLFALLVWNAKSKEVD"
     CDS             complement(13512..14432)
                     /locus_tag="ctg46_17"
                     /transl_table=11
                     /translation="MKNYLIIGIILLFPFRLFADEPVKAIYAKITNPDNKEVTVVAHRA
                     DWRFAPENSLAAIESSIRLGADVVELDVQKTKDGQLILMHDKTLDRTTTGKGKVAEWTL
                     DSIRTLRLKNGAALRTKHRVPTLEEALLTAKGRVMVNLDKAYPIFDEIFPILEKTGTVE
                     QIIMKGSKPVAEVKKDLGKYLDRIIYMPIVHLDRPGAMQQIDDFMKELHPVAFELLFES
                     DTCQLPQQVRTKLEGKSKIWYNTLWDTMAGGHDDDKSLENPDEGYGYLIDKLGATIIQT
                     DRTAYLLEYLQVRKKRNEHKIDVFH"
ORIGIN
        1 tttcatgatg caaaaataag aattttaacg caatccccca aggtttcaga ctgagccatt
       61 ttaacgcaat cccccaaggt ttcagactga gcccttgcac ccggtagcta atactcatgc
      121 cgagcgtact aaaaagcggc tactttgaaa aaccaaggca gccgctttca aacatttttt
      181 taacaacaaa caaaaaagcg gagagaacga gattcgaact cgtgataccc tttaggggta
      241 tacacgcttt ccaggcgtgc ctcttcaacc actcgagcac ctctccttat aattaccaac
      301 tagagaacaa ctctctataa aaacagaaag cagcaaaaag ctgctttcta gcggagagac
      361 agggattcga accccgggta cctcgcagta caacggtttt caagaccgcc gcaatcgacc
      421 actctgccac ctctccaaaa cttctttatc agaagtgctt tttgttaaaa gcggtgcaaa
      481 gatacaactc ttttttttaa tacgcaaata tttttaagac aaaaaattcg gaaatatttt
      541 ctgcataaac gatgaagacc gtgaaagtag tctatttacc gctcgcaaat ttattctcat
      601 atttcttttg tatatttgct ttttatgcat atcttcgccc tgttttcacg gcaaaataaa
      661 catattataa gcgaaaaaca acatgagaag tatatttaag gtaagtattc tttttctttg
      721 cctgctcaca cattcctttt tatcggctgg caacctgccc gaaaaaaata taaaacatat
      781 tctgattatt agtgcttatg ctgattctaa cccatggagt aacagtttca ttactcccat
      841 cgttacgatg gcctcacaag acagcaccat aggagtttat accatcaact tgaaaatgtt
      901 tgcagtgcag aagaattcgg taaatgtaga gaagtttgaa gaaggtatat gtgagaagct
      961 tccccaatac actcctaaaa tggtggtatt tataggaaat gccagtttcg tattttgcga
     1021 taacctgaat aagatatggc cggacattcc catgttgtta tgtggtgaac gagactacac
     1081 ggggcccgac agtctcatca ttgaggctca cccactcact ccacaacagc ggattccaat
     1141 cagcgacctg caaaagacaa tgaacctgac catgatgcat gcaaaactct acatggagga
     1201 aaacctgcaa cttatgaaac aactcattcc tcaaatgaag aaggtgattt atatagctga
     1261 cggtacctat atgtgccagc aaaacaatta tgacctctca actattatca aagaaaaata
     1321 cccggaactg gattatcagc ttatctcggc agaagacact tccaccgaca gtctcttcgc
     1381 aattcttaat caacagaatc cacgtactac cggacttata ttttcttcct ggctacgtag
     1441 aaaagactat gaagacaacc ttgtgatgac caccaactca caccgcatca tagccacttc
     1501 gcctgtccct ttgttctcat tcagaaaagt aggaatacag gaagaagggg gaatcgtagg
     1561 cggctatatc tataatgaaa agaagtatat cgaccggatg ctaaagacca tcaaggatat
     1621 actccacgga cagcaaccac gttacacccc aatctatcat gccgaggatg caacacccat
     1681 atttaattat caatccttaa ttcagcgcaa cctcgacccg aaacgttgtc ccggtaatac
     1741 gatcttctat aacgctcctc ccaccttttg ggagaaatac gaatacacaa ttattggaat
     1801 cgcctgccta gttattctat tattactatt tttccagtac catcgcgtgc gtgtactcga
     1861 aaagatgaag cgtatccaac acaaagaact ggaaagcacc ggtaaatatt ataacattat
     1921 caacaacatg cctatcctct acatggtgga agaacttata aagaatgatg acgggcggat
     1981 tgtagacacg atgtatgtag acgtaaacaa gcatttcgaa aagaaattct tcgaaaagca
     2041 ccaaattatc ggtaagcggg gaagtgaaat attcccggaa tcactgccac aatttctgca
     2101 tttcatgaat atcgctttaa aggaaaaacg ttccattacc ttttcttatt attataaaga
     2161 gatagacact ttctacgacg tagtagtaaa tgccagtagt gacggacgct tcatggacgt
     2221 attctgcatg gacagtacag agttgcatca tgcccaaatg caaatgcgtt ccatcaatca
     2281 caaactgtct atggcactcg acatagccaa tatcatccct tggaaatggg atttaaagac
     2341 acataccatc cattatgatg taaacaaggc actaagtaac gagaatcaag aaataaacga
     2401 cgaacaacta tccatgtccg acgaacagta tttcgcaaaa atacacgcag aagacctctc
     2461 taaagtgaaa gaaatatgca ccaatttcat aacgggacac tgcaaaaaag ccaaattgga
     2521 atatcgcgtt ctcaataatg tgaatggagc gaaacgaata gactggatag agacccagat
     2581 cgcaatagac agttatgacg aaaacggaca gccggaaact ctgataggtt cttctctaac
     2641 catcaccgac cggaagaata tggaaattga tttgatttcc gccaagaacc gggcagaaga
     2701 atccaaccgt ttgaaatctg ctttccttgc caacatgagc cacgaaatcc gcacaccgct
     2761 caacgccatt gtcggatttt ccggaatatt ggcatccacc gaagaggagg aggaaaaacg
     2821 agagtatgtc agcatcatcg aaaacaataa caccttgctt ttacaactca tcagcgatat
     2881 tctcgacctc tcgaagattg aagccggtac tatggacttt ctctatacag acttcgaact
     2941 gaacaaggta atggaagagc tggaacagtc gttacgccta aaactatccc ccgacagaga
     3001 agtcacgctt acactcacaa ctccgcaacc ggaatgttat attcatgccg aacgtaaccg
     3061 aatttcacaa atcatcatca atttggtaac aaacgccatc aaattcacag aaacaggtag
     3121 catacatttc ggctatgaaa tacgcgaaaa agagatactt tatttctatg tgaccgatac
     3181 cggatgcggt atttcagaag acaagcaaga aagtgttttc ggacgcttcg tcaagctgaa
     3241 cagctttgta caaggcacag gcctgggact ttccatttgc caaaccctca tccagcagat
     3301 gggaggtgaa atcggcgtac attcaaaaac aggcaaagga tctacattct ggttcactct
     3361 cccttaccat cctacgcttc aagcaccgca acaggaagta gcagaagaac ctgttaaaat
     3421 caagaagcag aaaatctgta ttctggtggc cgaagaccat agcagcaact accgtttgat
     3481 agagtccatc ctcaagaaag actacaactt agtacatgcc tggaatggag aagaagcagt
     3541 aaccttgttt aaagagcaca atccgcagct tatcctgatg gacatcaaca tgccagtgat
     3601 ggacggatac gaggctacca aagaaatacg caaatactcc caacgggttc ccatcatagc
     3661 cgtcacggct tttgcctatg cctcggacga gcagagagtg atggaaaacg gatttgacgc
     3721 ttatatgcct aagccaatta acgccaatca actgaaagga caaatttcat ccatactgat
     3781 gaaacatatc acttttatgt agccataaga agtcatttcc aaagaatagc aatatctagg
     3841 tattttatgt tgaaaagcat aaaatagagc atatttatgc tgattatatg aaaaaacgtt
     3901 gtaactttgt acgctctaaa gaaaaggata actacaacct ctaattttat catttatgga
     3961 attaaataag atctttaaag acggtctttg gagcacagaa atcaacgtaa gagatttcgt
     4021 tagtcacaac atcactccgt attatggaga tgcttctttc ctcgaaggac ctaccgaacg
     4081 cacaaaagct gtatggaacc gctgcctcga agcactggca gaagaaagag ccaataacgg
     4141 agtacgctca ctggataatg tcaccgtctc aaccatcact tctcataaag ccggatatat
     4201 cgacaaagaa aacgaactga tcgtcggtct gcaaacagac gaacttctga aacgtgcaat
     4261 caaacctttc ggaggtatca acgtggtgag caaagcctgc cacgaaaacg gcgtggaagt
     4321 ggacgaccgt gtaaaagata tattcactca ctaccgcaag acgcacaacg acggagtatt
     4381 tgacgtatat accgaagaaa tccgttcgtt ccgttctctg ggattcctca ccggacttcc
     4441 tgacaactat gcccgcggac gtatcatcgg cgactaccgc cgtatggctc tctatggtat
     4501 cgaccgactg attgaggcaa aaaaagaaga tttgcgtaac cttaccggtc cgatgaccga
     4561 agcccgcatc cgcctgcgcg aagaagtggc agagcaaatc aaggcattga aggacatgaa
     4621 ggtaatgggc gaatactacg gactcgactt gagccgtcct gcctacaccg cacaagaagc
     4681 agtacaatgg gtgtacatgg cttaccttgc tgccgtaaaa gaacaagacg gtgctgccat
     4741 gtcactgggt aacgtctctt cgttcctcga catttatatg gaatatgaat tgagcaaagg
     4801 aaccatcaca gaatctttcg cacaggagct gatcgaccag tttgtcatca aactgcgtat
     4861 ggtgcgccac ctgcgtatgc aatcttacaa cgacatcttt gccggcgacc cgacatgggt
     4921 aaccgaatct ctgggcggac gcctcaacga cggacgcacc aaggtgacaa agacttcttt
     4981 ccgcttcctg caaacactct acaacctcgg cccttcaccg gaaccgaacc tgactgtatt
     5041 gtggagcccg gaactgccgg aaggattcaa agaattctgc gcaaaagtat ctatcgacac
     5101 ttcttccatc caatatgaaa acgacgacct gatgcgtgaa gtgcgccagt ctgacgacta
     5161 cggaatcgcg tgctgcgtat cttatcagga aatcggaaaa caaatccaat tcttcggcgc
     5221 acgttgcaac ctggcaaaag ccctgctgct tgccatcaac ggcggacgtt gcgaaaacac
     5281 cggtacggta atggtgaaaa atatccccgt actaaccagc gacacactga acttcgaaga
     5341 agtaatgagc aactacaaga aggtattgac agaaatcgcc cgtgtttaca acgaagcgat
     5401 gaacatcatc cattatatgc atgataagta ttactacgaa aaagcccaaa tggctcttgt
     5461 agataccaac ccacgcatca accttgctta cggtgtagcc ggactttcta tcgccctcga
     5521 ttcactgtcg gccatcaaat atgccaaagt aaccgcacgc cgcaacgaca tcggtctgac
     5581 agaaggtttc gatattcaag gcgaattccc ttgcttcggt aatgacaacg acaaggtaga
     5641 ccacctgggt gttgacctgg tctatttctt cagcgaagaa ttgaagaaac ttccggttta
     5701 caaaaatgcc cgtcctactc tgtctttgct caccatcact tccaacgtga tgtatggcaa
     5761 gaaaacaggt gctactcccg acggacgcgc caaaggtgtc gcttttgctc cgggagccaa
     5821 cccgatgcac ggacgtgaca agaacggtgc catcgcctct ttgagttccg tagcgaaatt
     5881 acgttaccgc gactcacagg acggtatcag caacaccttc tccatcgttc cgaaatcact
     5941 gggagctact gaagaagatc gcgtagaaaa tctggtgaca atgatggatg gttacttcac
     6001 caaaggcgct caccacctga acgtgaacgt actgaaccgt gaaatgcttt acgacgccat
     6061 ggaacatccg gaaaaatatc cgcaactcac catccgtgtt tccggttatg ccgtaaactt
     6121 cgtgaagttg agccgcgaac atcaattgga agttatcagc cgtagcttcc acgaacgtat
     6181 gtaatcagat ctactcaata tgacgataaa cgtacattca tacgaaagta tgggaacatt
     6241 cgacgggccg ggcttacggc tcgtcgtttt tcttcaagga tgcaatttcc gctgcctata
     6301 ttgcgccaac cccgacacaa tagccggaaa aggaggcaca cctactccac cggaagaaat
     6361 cgtccgcatg gctatgagcc aacgtccttt tttcgggaaa cgcggaggag tcactttctc
     6421 cggaggagaa cctacgtttc aggccaaagc actagtccct atagtgcgtg aactgaaaga
     6481 aaagggaata catgtatgca tagacagcaa cggcggtatc tggaacgaag aagtagaaga
     6541 acttttcaaa atgacggatc ttgtattgct ggatattaaa gagttcaatc cggcacgcca
     6601 tcaggcactg accggaagaa gtaacgagca aaccatccac acggcagcat ggctggaaga
     6661 aaacgagaaa cctttctggc tgcgttatgt attagtgccc ggatacagcg atttcgaaga
     6721 ggatatccgc cgcttgggag aggctctggg aaaatataag atggtgcaac gagtggaaat
     6781 cctgccttat catacattag gcgtacataa gtatgaagcg atggagcagg aatacaagct
     6841 gaaagacgta aaagaaaata cccccgaaca acttgaaaaa gccgcggagg tatttaaaga
     6901 gtatttcact actgtggtgg tcaattaacc accacagtaa taaataggat aaaaatcacc
     6961 atgtctctgc tttcacttca aaacagggac actctttgat ccgttcccag gggtctacaa
     7021 ttccattata attagtgtca gggctcaagt cccggtgacc gaccaccttt gcatccggat
     7081 aacgctgcaa caactcgctt accagacgat gcatcgcctc tttctggcgg gaagtacgtg
     7141 tatccgctgc ctttccgttc tcatccagcc cgccttcata gcacacccct aaactaatcg
     7201 cattaaaacc gcgtgcatga gcacccaccg tatcttcatc cctcatcggt tctatctgtc
     7261 ccgacttgcg gatataataa tgataccccc aacaagaaaa gccccgaaag cgatgggcag
     7321 tgtccacatc cttcgccgtg aagtcgcgat cagcacgggt agcagagcag tgaatcacaa
     7381 tcagactaat ctttctcatc gtccttttcc ctttccgttg ttttcacatt acacacttcc
     7441 ttatgggtag cattgaagcg cacctctctc acaattctgt tccgctttct ttttccgaag
     7501 aaaggcacaa ggaacatgat tacatccaaa atcttagtta caatttcttt catttgatct
     7561 aatattaaag ttatcatgct gccggatccg gagcttctcc gcttccacca ccgtctgaac
     7621 cgccaccgga acctttgtca tcgtcttctc cttcattgcc gctaccgccc gtttgggcca
     7681 ccgcacgcgt cgttacctgt tggtagctaa gaatcttcgt gatgtccgcc aacgtctttc
     7741 cgggacggaa aataatatgg gcagccgtaa tcagcgaact tgaaaactcc ttgaccgaca
     7801 cagctccttc actgttcaac ccgatctgca aactgcccaa atcacccagc cggactattc
     7861 ttcccgcttt caacgcacgc ttcgcctcat aaagaatacc cgaaatggcg gcacgcacat
     7921 ctgtctccgt acaggtagac cgactcgtga ttccctcgca caactcttca aaatccaact
     7981 ctcccgaagc ctgtgcctgc gcgtaatact ttgccgactc atcctttttg gcaggattct
     8041 tgcgcggcac tactgaataa gttactgtca ttgccataat aaaataattt taagatttca
     8101 cacatttcga acgcgttcct tatttgttaa cgacataaag ataacacatt tttcaccctc
     8161 cggattcccc aacgaagttt cctgatattc tatgaataat aatgacgtta ttcttttaat
     8221 aaaccattaa ttttcagtaa ctttatagca taaaccaaat atcattcatc atgtattatc
     8281 cggatcagcc gtttcatatc cgcacttata aaaagtcgga actagctcat ctttacaacc
     8341 ccaacgtatg tctcaaagta gccttacaaa tactacgtcg ttggattgtc tacaaccttc
     8401 cgctcctgca agaactcgaa caagaaggct atcgtgcccg caaccgcctt ctctctcccc
     8461 ggcaagtggc aacgatcata cgctatttgg gagaacccta ggaacttaat caaaaaaacg
     8521 aaaagttcca ttctattatt ttacaaacaa atttctttgc aaccgcaaat taaaaagaac
     8581 aaaccaacat ggagcatttt accatctttc aagactttta ccgcgtcata gccgaaatga
     8641 cagaagaaga aatcgtatcg gccatcagca acggcacata ccgggaaaca gtggaggacg
     8701 tgcgccgaat cttcgcggaa caaggcgaga aagcagcaaa cgaaaagaaa atagaactac
     8761 cggaaatcac cttttcagcc aactaccggg gaggacgttc aaacgcaact ctcgtcaagt
     8821 atctgggata catcgtggta gacatcgacc atcagacaca ggaagcattg gcacgcatcc
     8881 tcgcactggc aaaaaagtgt gcccacaccc gcatcgcttt catcagtccc aaaggaatgg
     8941 gactgaaaat cgtggtacgt gtatgccgga cggacgggac attgcccgaa acgattcagg
     9001 aaattgaaga tttccatcat gccgcttatc acaaaatcgc ttccttttat gcccagctct
     9061 gcggagttga ggtcgacact tccggacaag atgtcagccg cacttgcctg ttctcttacg
     9121 atccggatat ttatttcaat cccgatgcca cagctgtcat cgtggaacag ccaccgatgt
     9181 tcttcaagtc tcaaaagaag aaaagggcat ccggcaaaaa gaaaaagacg acagcaccag
     9241 acaacaatcc cctcaccgaa caagtggcac tcaactacca ttcctcgcac gcttccttaa
     9301 tggtgactct gaactattat cacaataaat ccgaaaagta cgtcaccggc aaccggaaca
     9361 actacctgca ttgcctggct tgtatgtaca atcgctacgg cgtcccccag gaagaggcgg
     9421 cagcttttat caagagccag ttcaccgatc ttcccgcgga tgaaatggac gcactgatcg
     9481 ggagtgctta cggacacaat gaggaattcg acacccgcaa gctgaatagt acgcagaagc
     9541 gaatattaca gattgagcaa catatcaaag aaaattacga tacacgctac aacgaagtgc
     9601 ttcatatcat ggaatatcgc agaaggaaaa cggacacgga gcaaccggaa cctttccata
     9661 ttctcgacga aatgatggaa aacagcattt ggatggagat gaacgaacta ggctattcgt
     9721 gcaccgtcaa aacaattcaa aatctgatct actccgactt cagcagcact taccatccta
     9781 ttcgcgaata tttagactcg ctgcctgaat gggacggaac ggattatatc ggtatccttg
     9841 ccaacagcgt gcatactagt caccagaaat tttgggtaga atgtctggaa cgttatctgg
     9901 tgggaatgtg cgctgccgcc acacaagacg atgtggtgaa ccacactgtt ttgttgcttt
     9961 gcagcgaaat acagaacatc ggaaagacta cgtttatcaa caacctgctg ccgcccgaat
    10021 tgcgcgccta tctttctacc ggtcttatca acccgaacaa caaggatgat ctggccaaaa
    10081 tagcgcaggc gatgcttatc aatctggatg agtttgaagg gatgaacgga cgggaactga
    10141 atatcttcaa ggatttggtt acccgcaaag taatcagcat ccgcctgcca tacgcgcggc
    10201 gttcacagaa cttccctcac acggcttctt ttgccggcac atgcaattat caggaagtgc
    10261 ttcacgacac cacaggtaac cgccgttttc tctgctttca tgtcaactcg atggagttta
    10321 tcaaaataaa ctacgcgcag ttgtatgcac aaatcaagta tctgctcaac aagccggggt
    10381 atcagtattg gttcacccag tcggaaaact cacggattga agagaacaac gaggatttca
    10441 ttttccactc accggaagaa gaactggtgt tgacacatat ccgcaaaccg gaacgtttcg
    10501 aaaaggtgca ttatctgacg gtcactgaaa ttgcggaatt gattcgcgaa cggacggggt
    10561 atcaatattc tcatggaacc aaagcccaac tgggaaaagt gatgtccaaa catggcttcg
    10621 aatttcataa gggaaaaaac gggagaagat acactgtatt cattattgat acggaacagg
    10681 tgaaatcaaa caggctatat gaataagatt tcatctcctt cgcacgcaaa aaggtgaggg
    10741 ttggtgaggg tacttttgca acttttcatt tttatatttc ttatttctat tcttctattt
    10801 tcttctaaaa aaaaatacga atgttagaaa tttaccctca cctaccctca ccttttcctt
    10861 tttcttcctc aaaaaaacgg tgggaaattt gaaaaagaca gttatctttt tcaaatttcc
    10921 caccatgttt tttttaatcg ctttttataa agacatcgaa aattcgatcc tacaacctaa
    10981 cgcattcatg atgcgataga aggtagaaac cttaggttct gtctgaccac tttccactct
    11041 tgaaatataa gaacggtcgg aaccgatacg ccgagctaat tctgcttgag taatcttagc
    11101 ctttttcctt gcgtcttcga taatttgccc ggtgtagaaa gcatacgctt tttcttctgc
    11161 ttccgcacgt tcgggagtac cttctgctcc aaatttcgca tcaagaacag cgtcataatc
    11221 tactatttga tgattgttta tctgcataat attcctcctt tatttttaat gctttatcta
    11281 tttcactacc cggtgttttt tgcgacttct tttgaaagcc attaaacaac actacaatat
    11341 ttccatcatc aaaaatgaaa aatacccggt atatattacc attatattct gtacgaagtt
    11401 caaaaactcc gtcctgaaca aattttacaa atttagtgga gagtctttct tgtgttttca
    11461 acaagagtag tccatactgg attttatctt gttccttttc ggttaaagtc tccatgaaag
    11521 cctcaacgta acctccgtat gtacggaggt tacgttgagg ctttccatac tgcaaatatg
    11581 cgaattgttg ttcaactata caacaatcgt ctttttattt tatattattt ttcctcaaat
    11641 tctccagcac gctttttctt ctcataagac accagcgtct ctacactaag cgttttccca
    11701 ttcttaggac ttatcacatc tacaacgctt gctaacgcac gaaaagtctg ttcgcaattt
    11761 gctactccgt catacgtcaa cctacccaga ttgatggcat cgagcacaac agagacatat
    11821 tgcttcggat ttccccgata ctcgatgatg acaggcgtga gatgcgacat ctctcgagtc
    11881 aattgactga cgattctttt ttttggtcga gcagatccat taatttttca ctatgcacat
    11941 tgatttgtgc ggttacttca cgaagttcat ctttcaatga acacaataat tcatcattca
    12001 atgaattttc cataaaactt tctatttaat tgattataaa aaagccattc cagaaagata
    12061 agcaatcatt acttacttcc cggaatggtg tctaatacct cgaaaacaaa gacttatatt
    12121 ctaacctaat gtactcactt taatccactt cttttgattt tgcattccat accagcaaag
    12181 caaacaacac cgaaagcaaa gcagcaccaa tccaaaacca attgatatag gtgaagtcat
    12241 aaacatctac tccattctga acggtctttt gcccttctat cagtataccg ctcatcacgt
    12301 cctgcaatcc ggcaccgatg taactggcaa tgccgactac tcccaatgca gcacccgaag
    12361 cattacgggg agcaatatcc actgccatca aaccacccag aaaacagatc aaaactccga
    12421 tacctaaacc gaaaagtacc attgccaaca cgtctatcca aaaatgtacg cccggaacca
    12481 agagaaacag acaaagtgct attacattca tcaacccaaa tactaaagct ggaatattac
    12541 gactgccgga aaacatttta tcggaaatga taccggaaaa caccgttcca atgatcccac
    12601 agatagaact gattgatatt ataaaactgg catccagcgt agaatatccc ttttgagctt
    12661 ccagatagaa aacaccccaa ctatttaccg catagcggct aatatacata aatgcactgg
    12721 acagagccaa aatccaaatt gcaggattct tcaagacagc cttttgtgct ttgttgaaat
    12781 cttccgtttg tttaccagac aaagaatggg aatccacaga tgaagaattt ttgttcaaca
    12841 agaatccctg actctgtggc gtatcacgca taaagacaag catcataaag aaacctaata
    12901 tcccaataat gccagctcca atcatcccat acctccatcc catccaactg actaacaagg
    12961 ctatggaaat aaaggttaat gcttcaccca aattatgact agcagaccaa aagccgtaaa
    13021 aagttccccg ttctttacta ctgtaccacc gagtgagcga aaccactccg gatgctgctc
    13081 ccatcgactg aaaccaacca ttcaatcccc aaagtaaagc aaaagcataa aaggagctag
    13141 tgaaacctaa acataaattt atcaaagcgg aacacaataa cccggtagac ataaaacgcc
    13201 gaacattact acggtcagca agaaaaccat tcgtcaactt acccactgca tacacaaaaa
    13261 acagacagga accgatgatt cctaattgcg tttcggaaaa tactccctcc tctacaattg
    13321 gcttgcgcac tacattcatg ctaagacgac aaacatagta aatgccatat ccggtagtag
    13381 ccgacaaaaa tgtagcccaa cggatgcgct taaagcggga agaatcttct gaatcagtct
    13441 ctcccccggc tagcggggaa gagattttat aaaaatccaa tattttaaat gacataaccg
    13501 aagtttacat attaatgaaa gacgtctatc ttatgctcat tacgtttctt acggacttgc
    13561 aagtattcca gtaaataagc ggtacgatca gtctggataa tcgttgctcc aagtttatct
    13621 atcaaatatc catatccttc atccgggttt tccaatgatt tgtcgtcatc atgtccgcct
    13681 gccatcgtat cccaaagggt attataccag attttacttt ttccttccag cttcgtcctc
    13741 acttgttggg ggagttgaca agtatccgat tcgaacaaca attcgaaggc taccggatga
    13801 agttctttca tgaaatcatc tatttgctgc atagctcccg gtcgatccaa atgtacgatt
    13861 ggcatatata tgatccggtc taaatatttt cccaaatcct ttttcacttc tgcaacaggc
    13921 tttgacccct tcatgatgat ctgttcaacg gttccggttt tctccagaat ggggaaaatc
    13981 tcatcgaata tcggataagc cttatccaaa tttaccataa cgcgcccttt agccgtcaat
    14041 aatgcttcct ctaatgtagg cacacgatgt ttggttctca aagcagcgcc attcttcaga
    14101 cggagtgtac ggatagaatc cagtgtccac tcggcaacct taccttttcc ggtggtcgtt
    14161 ctatccaaag tcttatcatg cataaggatc aactgtccgt ctttggtttt ctgaacgtcc
    14221 aactccacga catcggctcc caaccggata gaactctcta ttgctgccag cgaattttca
    14281 ggtgcaaagc gccaatccgc ccgatgggcg actacggtta cttctttatt atcaggattc
    14341 gtaatctttg cgtaaattgc cttcaccggt tcatctgcaa acaagcggaa aggaaacagc
    14401 aaaataattc ctattatcag atagtttttc atattcattt ttatcatcta tactttgggg
    14461 gattatctat actttttgga ttttaaatac ttggcagcta attcggcata atcagtctgt
    14521 acgacattaa tacgtttgtt tatcatgcct accaaccccg aatagttgtc cgacaacatg
    14581 ttcgtatcat tcgctcctac gatattggag aataaaagcc aacctttgga tttaatgtct
    14641 tccgtcatcg ctcccgcaag agcatccgag gtggaaagtt gcatcatctg cacattgtcc
    14701 gtgtaagatg aagcaaaata ggtaatatca tctgaagctt ttgccatcgg atgcagtaac
    14761 agagtgctgt tcgccgcttt caaatcgtat gcataattac ggttgtttga aacataaagc
    14821 aggacttcgt tttccatgtc gagtttttta agtaatgcca ccattgtcgc tacggcaacg
    14881 tttttgttga ctatatccaa gttaaaataa acctttcctt tgcctttctt caatgcgtcc
    14941 tctaaagtgg ggattcgttc gtttgtcaga ttccctgctg catctttaag atagagttgc
    15001 tgtaattgct gataagaata atctcctacc gcaccgcttc cgttagtggt tctgtcgatc
    15061 gtattatcgt gcatcagcac caatattccg tcagaggtgg gacgtgcatc aagttcgatc
    15121 atttctactc ctgcattgat tgcatactct atggaagtta atgaattctc cggtatgcca
    15181 tcggctatac ctttctgcgt gttcgcccga tgggcacaaa gccagacctt ataggaacta
    15241 tcatcaaata aattctttaa atcggtcttc agatttcctg taataggcaa ttgtccgccc
    15301 ggttcgcctc ccggattctc tcccgagcct cccaactgtg cactggtgtg gcggctgtct
    15361 ttccctttca tcggccatgc cgaagctgca catccggtta taccttcatc ttccaaagct
    15421 accaggacac tcttcgacgg atctaccgtg tgagtaacgc caatatagat cgttccatcc
    15481 ggtccgattg taggcgaact ccagattttt ccgatacccg cttcccagtt atcttttaaa
    15541 ggagaatcgc tctcgctaat cagtgcagcc aagtcttttt tcaagattag ctgttcttcc
    15601 gaggattcgg gtttaatgat ataataatta ccggattgcg ttccaaaatg aatatttccg
    15661 gcctgatcga ttgccgcaca tccactgacg tcttccggca caccgtaatg ccattgaaca
    15721 actccattag gagataatgc aacgattcct cctgtggctt cacccggagc acgttttacc
    15781 gttacaatga tacttccgtc caagcctatc acaacacccc cttggtctag tgttcctaca
    15841 tttcctaacg aagtacgcca tttctcaacc ccgtcgcttc caatagcaaa cgcactgctt
    15901 cctatactcg ggaaggtggc aattccgtat atagtgccgg ttgcgtccac agctacggaa
    15961 gcattcatgt tttctgaagg cttatcattt cccgaactat atatttgcca tgcccacatc
    16021 acattaccac ctgtattcag tgcagacgcc gacgcgccga ataagccgtt ctttccacca
    16081 gcccaaatta atgtgttgtt cgccaatgct attccggcag atactccccc cgacgggcct
    16141 ccggaattgt ctgcgtttgc cacataacct actctgtaac cggtattctt atcgacagca
    16201 agcacagatc ccgtagagcc gccgttaccc atatagatat gattctctcc aatcgcacaa
    16261 gtcagataat taatacgagg ctttgaagcc tgtcctttat tccaaaatcc tttttcagca
    16321 tctccggcaa cgacccattt ctttgttcca tcgggattga tggcatatac gcgccctatt
    16381 ttgccacttg tgtcgcctgt tcctacatac acagtaccgt ccgtatcaat gctcggagtg
    16441 gtatgcgtat taccggacgg agaatcaccg tcagccgatg tccataagtc gaactcccac
    16501 aattgttcac cggtaacggc tgaaaatttc cgcaaataat ggtcattgga agtcatatat
    16561 acattattat catcactgac tgccggagcc gtagaacgta tttcgcccaa cacgtgggca
    16621 cctacccatt tcagtttcac attgccgact tcgggcagag gttcagcttc aatcgtcaat
    16681 aatttatgag ccattgcata atttccttta ctgtctttca catgcaaagt cactgtatat
    16741 gctccattcg tttcgtaagt cactttagga gcaacttctg ttgaagtctc tccattccct
    16801 aaatcccatt ggcaggtata attaccttct ccgcctactg tctcattcgt gatactgact
    16861 tcttcgccta catagtaggt tgtcttgtca aaagtaaatt tagctgtcag cgcattttct
    16921 ttccaatc
//
