LOCUS       gnlProkkaHIFHIOLO_24   13845 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HIFHIOLO_24.
ACCESSION   gnlProkkaHIFHIOLO_24
VERSION     gnlProkkaHIFHIOLO_24
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 13:51:16
            Original ID  :: gnl|Prokka|HIFHIOLO_24
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 105221
            Orig. end    :: 119066
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13845
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10345]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10345
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..13845
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13845
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             2131..3165
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg24_70"
                     /sec_met_domain="PF04055 (E-value: 8.4e-18, bitscore: 57.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKYPLLGMTLVELQSLTKRLGMPGFAAKQIASWLYEKKVASIDD
                     MTNLSLKHRELLKQNYEVGAEAPVDEMRSVDGTVKYLYKVGENHFVESVYIPDDDRATL
                     CVSSQVGCKMNCKFCMTGKQGYTANLTASQIMNQIHSLPERDKLTNVVMMGMGEPLDNL
                     DEVLKALELLTATYGYAWSPKRITLSTVGLRKGLQRFIEENDCHLAISLHSPLTVQRAE
                     LMPAEKAFSITEMVELLKNYDFSKQRRLSFEYIVFKGLNDSQVYAKELLKLLRGLDCRV
                     NLIRFHAIPGVDLEGADMDTMTRFRDYLTSHGLFTTIRSSRGEDIFAACGMLSTAKQEK
                     NNES"
     CDS             3184..4224
                     /locus_tag="ctg24_71"
                     /transl_table=11
                     /translation="MKKYSFILCIALVAFVVASCGLKGNHTSSGRAYELLVVVDHGVWD
                     RAAGRALHDALDADMPGLPQSEPSFRIMYTSPKDYDSTLKLIRNIIIVDIQDIYTKASF
                     KYAKDVYANPQMILTIQAPNEEEFEKFVEENKKTIVDFFTRAEMNRQITFLEGKHSNFI
                     SQKVDSLFGCNIWVDAELANSKTGDDFFWASTNTGTADRNFVMYSYPYTDKDTFTKEYF
                     VHKRDSVMKANIPGFKEGVYMSTDSLLTDVRPINVQNSYTMEARGLWRMKGDFMGGPYV
                     SHTRLDEKNQRIITAEIFVYSPDKMKRNLVRQMEASLYTLKLPNEVQQKQIPLGEASKE
                     AEQTNK"
     CDS             4229..5323
                     /locus_tag="ctg24_72"
                     /transl_table=11
                     /translation="MEDNKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPK
                     VAAYHRKALDIQTNFSIVNSATEAGYNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     RAIEEYREGLIDVIVTAPINKHTIQSEEFSFPGHTEYIEERLGNGDKSLMILMKNDFRV
                     ALVTTHIPVREIATTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLG
                     MEEQEVIIPAMKEMEEKGILCYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAM
                     EDGVNYTAGLPVVRTSPAHGTAYDIAGKGVACEDSFRQAIYVAIDVFRNRQREKVARAN
                     PLRKQYYEKRDDSDKLKLDTVDED"
     CDS             5333..6574
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 390.4; E-value:
                     2e-118)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg24_73"
                     /transl_table=11
                     /translation="MTKAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMSTQARLLRVLESGEFMKVGSSKVQKTDVRVVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQMGTVVTTPVVTAHQPSVPA
                     IIHTKQPTVCKDDDDIQDTEEYVEESPLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             6561..7088
                     /locus_tag="ctg24_74"
                     /transl_table=11
                     /translation="MNWIKKIIRPLLLFGLPLVVIACTVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPSQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSTQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             7094..7867
                     /locus_tag="ctg24_75"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSYLLEGTPATEQSAEETPKLKGYELIDDFIEK
                     SESDSPLCMKPLREEMPSSPTSSDELTEEETMKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             7874..8269
                     /locus_tag="ctg24_76"
                     /transl_table=11
                     /translation="MYLLFVILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSIATAYVVPRSAVAKDAVLEQAQKEQQTNPYNLPAGTAAP
                     QTEAPATNAPATETPAPATETPAPAAE"
     CDS             8517..9905
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 95.3; E-value: 4.9e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg24_77"
                     /transl_table=11
                     /translation="MTEHLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AISTTFPEGAMLFGFKTQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGYTDEGGAFHTNIPAPILFCLIMLCVGTIAFFLYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMVIGSLMLIFVHTMFAL
                     PILNIWWFATIIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMTIFALFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             10001..10345
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg24_78"
                     /sec_met_domain="PqqD_RRE (E-value: 6.3e-10, bitscore:
                     31.1, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.5e-16, bitscore: 52.2,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAKEKINLLEVIPCRSEHITAEREGETIVLSFPRFKYPWMQRFL
                     VPAGMSKELHVRLEEHGTAVWELIDGKRTVREIIEELADYFQNEAGYESRVSAYLSQMQ
                     KDGFIKLFIN"
     CDS             complement(10607..10891)
                     /locus_tag="ctg24_79"
                     /transl_table=11
                     /translation="MGGEGHMLDMIRRLSEGREASRLRRERANDKLKHLNRTNEPYPLP
                     NTTPEEMGRIIHDSEKKKEKDSNYFVWGTLIIMGVLIATAVIFWAIFLN"
     CDS             complement(10915..11982)
                     /locus_tag="ctg24_80"
                     /transl_table=11
                     /translation="MKKLIIAAGLLMTTSAYAQTEVLTGVTRGKDYGVVYSLPKTQIEL
                     EIKANKVNYTPGEFSKYADRYLRLTNVSADPEEYWELTSVKVKSVGVPNSETTYFVKLK
                     DKTVAPLMELTEDGIVKTINVPYSNSSSDKKTAPAPTVLSKIANPREFLTEEILMASST
                     AKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEEAMTQMFSGTRD
                     KEEKTFTVRLTPDREFNNEVAFRFSKKLGVVANNDLAGTPFYISLKDLKSVKIPQEDGK
                     KKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLFNKNSTIKVYFD
                     PNTGGLLKVDREEGK"
     CDS             complement(12055..13566)
                     /locus_tag="ctg24_81"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIENEPIASIDLMERAATVLTKAITDRWNT
                     ETPVTIFAGPGNNGGDALAVARMMAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEV
                     KFHEISTQFVPPVLTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPAMVVAIDIPSG
                     LMGEENTFNVKANIIRADVTFSLQLPKLAFLFAENTEFVGEWEVLDIQLSEDGIEEMET
                     NYEMLEIEEIRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPMCNNDILQTSIPEAIVETDINETCFTVPTDTDDYQAVGIGPGLGRNEETEAALLEQ
                     LEHCQTPVVVDADALNILANHRHALTHLPKGSILTPHPKELERLTGKCQDSYERLMKAC
                     ELARAAHVHIILKGAYSAIITPEGKCFFNPTGNPGMATGGSGDVLTGVILALLAQGYPT
                     EEAAKIGTYIHGLAGDVAQKKQGMIGMIASDIITCLPTAWRLVSE"
ORIGIN
        1 ggctacgccc atttccagct gaatggcttt tcacaggcgg atgccaagtc gttctcaaag
       61 caatatttgt ctacttactc caaggctttg tctgcacaac aggaagatat tcttgcttcg
      121 tgggtgctgg ctaaacaacc gcgctgttta agtgtattgc tcaacgagct ggtttcgttc
      181 ggtcagtacg atgctctcaa tgaatatatg cgtggatatt gccggctcaa tgaggttggg
      241 caattctatg acagtgtgct acggcgtttg tcggctgatt atggttccga agagattgga
      301 agaacgcttc tgatgctttc acttacttta gaaggattta ccgaagatga agtgaagagc
      361 atggcagaca ttaatcagat actttggtcg cagttgagag tggaaatgag cagctggctc
      421 accaacaaag gaggacgata ttgcattggt gacacacaaa tggtagaggc gatcgaacgc
      481 tatttcgctc aagatgacga atgtatagat gatagtcgcc atgaaattat ttccgctctg
      541 ctggatgagg aagaaatcct ttcccatccg ttgacttttg ccgattataa ctatcgcatg
      601 aaacagttct gctaccatga ttcgtatcgc tataaagtgg agattaccta tcaatgctat
      661 aagatgcaag aatgggatat attgaaggat tggatttgtg atgtggagat tttcgagatt
      721 ctgtatcgca cgaatcgttc tttgttggaa gatagctgga aagcgatcat gaacgacaat
      781 cctgaagtta cgcctgaagt ctatgccgaa ttggactttg atgagatcga ttctttttta
      841 attcctgtta ttgctaatga tatggctact ttcttgagca gttctttcca tctgacgaag
      901 gcggcagctg ctgtgagtga gaagagtatg gaaggtgctg ctatgccact cattgccaag
      961 tcggtattga agatgaatga gggatgccga tatgcccgta atgaagaata cgaaacggca
     1021 tgcgactgtt tcctgaaagc attggtgatg caggaaaaca ttgtaccgac tccggaactg
     1081 gagattgcca acacctgccg aaatctagct ctggcatatt actacaatga gcaatacaat
     1141 gaagcagtga tctatctgaa tagggcgctt gattatcatg cggcttctgc tgacgagaag
     1201 agtcaggcag aagtcattga actttccgaa tatctggctt attgtgatta ctataaggat
     1261 gaggaagaga gtgctgccga gaaattccgg aaagttgctg aaatgcacga gtcattgaat
     1321 ggcagactgt ccggtggagt ggctaaatgt ttgcgtatgc agggtaaatg tctttattat
     1381 atcaaacgat acgatgaagc atggatgctg atgaatcagg cgttggacat tgctatacag
     1441 atagataata aaaaacagat cgtcgcttgt cataaacagt tgtattatct atgcagggaa
     1501 ttcaaacgga tgatgaatga acgtggcgat gagcaggcgt ctactttatt cttccgtgag
     1561 tctcttctgc atgaaatgta tttcagcgaa aaaccgcgtc tggcggaact gactgtccga
     1621 tatgaggcat tgagatgtga tattatgcag cagtattaca tgaataaaga ctatgataac
     1681 gtgattcgta ttgcgacgtc tttggatatt cacgatgatg ctgaccctaa tgcttcctgt
     1741 ctggtatatt attacaaagc acaggcttat gtgaagttgg agaattatcc aatggcgaaa
     1801 gaggctttct tcagagagct tgaactgcga aagaaatatc tgggatggga ggatgaagat
     1861 acgattctgg cttgtcagaa cttaggggtt ttgcacagct tttgtaatga acgggaagag
     1921 gcgctggctt gtttccgtga ggcgtacggt tatgaagtga aaaagaatgg cgaggattct
     1981 gaaatggcgc aaaagctact tcaatatatc agcgtggttg aatcataacg gaggcatact
     2041 tccttttttg ttaactttta cattcctgct atacggaaat cgactttatt tccttacatt
     2101 tgcagatata aactatcaac agaaagaaga atgtctaaat atcccctttt aggaatgact
     2161 cttgtagagc ttcaatcatt gacaaaaaga ctgggtatgc ccggctttgc tgccaagcag
     2221 attgcatcct ggctttacga aaagaaggta gcctcgattg atgatatgac taatttgtca
     2281 ttgaaacacc gggagttgct caagcagaac tatgaggtgg gagcggaagc tccggtagat
     2341 gaaatgcgct ctgtagatgg tacggtgaag tatctttata aagtgggtga gaaccatttt
     2401 gtagagtcgg tttatatacc ggatgatgac cgggcaacgt tgtgcgtgtc gtcacaagta
     2461 ggttgcaaga tgaactgtaa gttctgtatg accggtaaac aggggtatac cgctaacctg
     2521 accgccagcc agatcatgaa ccagattcat tcgctgccgg aacgggacaa actgactaat
     2581 gtcgtaatga tgggaatggg cgagccgctc gataacctgg atgaggtatt gaaagcattg
     2641 gaactactga ccgctaccta cggttacgca tggagtccga agcgtatcac gctttctact
     2701 gtcgggctac ggaaaggatt gcagcgtttt atcgaagaaa atgactgcca ccttgccatc
     2761 agccttcact ctccgctgac cgttcagcgt gctgaattaa tgccggcgga aaaggcgttt
     2821 tcaatcaccg aaatggtgga actgttaaaa aactatgatt ttagtaaaca acgtcgactt
     2881 tcgtttgaat atattgtttt taaagggctc aatgattcgc aggtctatgc caaagagttg
     2941 ctgaaacttc ttcgcgggct ggattgcagg gtgaatctga ttcgttttca tgccataccg
     3001 ggggtagacc tcgagggagc ggacatggat acgatgaccc gttttcgtga ttatctgacg
     3061 tcacacggac ttttcaccac tatccgttca tccagaggcg aagatatttt tgccgcttgc
     3121 ggtatgctgt cgacagcgaa acaggagaaa aataatgaaa gttaatatat aaaaccgaac
     3181 atcatgaaaa agtactcttt tattttatgc atcgctttgg tagcctttgt cgttgcatct
     3241 tgtggtctga aaggaaatca cacctctagt ggtcgtgctt acgagctttt ggttgtagta
     3301 gatcacggtg tttgggatcg tgctgccgga agggctttac atgatgcgct cgatgctgat
     3361 atgcccggtt tgccgcagtc ggaaccttct ttccggatta tgtatacttc gccgaaagat
     3421 tatgattcta cgctgaagtt gatacgtaac attattattg tagatataca ggatatatat
     3481 acgaaagcct cgttcaaata tgcgaaggac gtgtatgcca atccgcagat gatattgact
     3541 attcaggctc cgaacgaaga agagtttgag aagtttgtgg aagagaacaa aaagacgatt
     3601 gtcgacttct ttacccgtgc ggagatgaat cgtcagatta cgttcctgga agggaaacac
     3661 agtaatttca tttcgcagaa agtggacagt ttgttcggat gcaacatctg ggtggatgcc
     3721 gaactggcta attcaaagac cggggatgat ttcttctggg cttctaccaa cacaggtact
     3781 gccgaccgta actttgtgat gtactcttat ccgtacactg acaaggatac gtttaccaaa
     3841 gaatattttg tgcacaaacg tgactccgtg atgaaagcta atatccccgg attcaaggaa
     3901 ggcgtttata tgtcgaccga tagtttgctg accgatgtcc gtccgatcaa tgtacaaaac
     3961 agctacacaa tggaagcacg tggcctatgg cgtatgaagg gcgactttat gggtggtccg
     4021 tatgtctctc acactcgtct ggacgagaaa aaccaacgaa ttattacagc agaaatattt
     4081 gtttattcac ctgataaaat gaaacgcaac ctggtacgcc agatggaagc atctctgtat
     4141 acactgaaac ttccgaatga agttcagcag aagcagattc cattgggaga agcatctaag
     4201 gaagcggaac aaactaataa ataaaaacat ggaagataac aagataagga taggtatcac
     4261 ccaaggagat attaacgggg tgggctatga ggtgattctt aagacttttt ccgaccctac
     4321 gatgttggaa ctatgtactc cgatcattta tggctcaccg aaagtagcgg cttatcatcg
     4381 caaagcgctg gatatacaga ccaatttcag cattgtcaac tctgctaccg aagcggggta
     4441 caaccgtttg agcgttgtga actgtacgga tgatgaggtg aaagtggaat tttccaaacc
     4501 cgatcccgaa gccggtaaag ctgcgttggg ggctttggaa cgtgccatcg aagaatatcg
     4561 cgaaggattg atagacgtta tcgtaacagc tccgatcaac aaacatacga ttcagtcgga
     4621 agagttctcc ttccccggac atacggaata tatcgaagaa cgtctgggca atggtgataa
     4681 gtcattgatg attttgatga agaatgactt ccgggtggct ttggtgacga cacatatccc
     4741 tgtcagagag attgcgacta cgattaccaa agaactgatt caggagaaac tgatgatatt
     4801 ccatcgttgt ctgaaacagg atttcggtat cggcgctccg cgtattgcgg tgctctctct
     4861 caatcctcat gccggagacg gtggtttgtt gggaatggaa gagcaggaag tgattatccc
     4921 tgccatgaaa gaaatggaag agaaaggaat cctttgctac ggtccttatg cggccgacgg
     4981 ctttatgggt tcgggcaatt atactcattt tgacggtatc ttggcgatgt atcacgatca
     5041 ggggctggct ccgttcaagg ccttggctat ggaagacggg gtgaactata cggcaggact
     5101 gccggtggta cgtacttctc cggctcatgg aacggcatac gatattgcag gcaagggagt
     5161 ggcttgtgaa gattctttcc gtcaggcaat ctatgttgcc atcgacgtgt tccgtaatcg
     5221 tcagcgggaa aaagtggctc gtgccaatcc gttgcgtaaa cagtattacg agaaacgtga
     5281 cgatagtgat aaactgaagc tggatacagt agacgaagat taaaaacgag tgatgacgaa
     5341 agcagagata caacaagtga aacagcgttt cggtattatt ggaaatactg aagcattgtc
     5401 gcgcgccata gatgttgcca ttcaggtagc tcctaccgat ttgtctgtgc tgattaccgg
     5461 agaaagtgga gtcggaaaag aaagttttcc gcagattatt catcaatata gccggaggaa
     5521 gcacgggcag tatattgctg tcaactgtgg cgctattccg gaaggtacga ttgattccga
     5581 actgttcgga catgagaaag gtgcgtttac cggtgcgatt ggcgaacgga aagggtactt
     5641 tggcgaagct gacggtggta ctatttttct tgatgaagta ggggagttgc cgatgtctac
     5701 ccaggcacgt ttgcttcgtg tactggagag tggcgagttt atgaaagtag gttcgtccaa
     5761 agtacaaaaa acggatgtgc gtgtggtggc agctaccaac gtcaatctta cacaagcgat
     5821 tgcagaagga cgtttccgtg aagatttata ttaccggttg aatacggtgc ctatccaaat
     5881 accgcctttg cgtgaacgtg gtgacgatgt acttttgttg ttccgtaagt tttccgcaga
     5941 ctttgcagag aaataccgga tgcctgctat tcagttgacg gaggatgcga agaaagagtt
     6001 attggcttac ccgtggcccg gaaacgtgcg tcagttgaag aacatcaccg agcaaatatc
     6061 tatcattgaa accaataggg agatctctgc tgctatcttg cagaattatc ttcccgcaca
     6121 aaatacgcaa cgtcttcccg cgttgatggg aacgcgtgag agtaaaggct ttgagagcga
     6181 acgggagatt ctttattctg ttctgttcga tatgcgccag gaagtggcgg agctgaagaa
     6241 gatggtgcac aacctgatgg cggaacgtgc cggacaggtg gggcaggtag gacaaatggg
     6301 aacggtggtt actactccgg tagtgacggc gcatcaacct tcggtacctg ctattattca
     6361 caccaagcag cctacggttt gcaaggatga tgatgacata caagacacgg aagaatatgt
     6421 agaagaatct cctttgtcac tggacgaagt ggagaaagaa atgatacgca aagcacttga
     6481 gaggcatcat ggaaagcgga agagtgcggc caaggacttg aatatttccg agcgtacact
     6541 ctatagaaaa ataaaagaat atgaattgga ttaagaaaat aatacgccct ttgttactgt
     6601 tcggcttgcc gttggtagtc attgcgtgca ctgtttccta taagtttaac ggatcgtcta
     6661 tcaattatga taaggtaaag accatttcga tagccgactt cccgatcaag tcggagtatg
     6721 tatatgctcc gttggcaacc aagtttaatg aggacctgaa agatatcttc atccggcaga
     6781 cccgtctgca actgctcaag ccgagtcaaa atgccgactt gcagattgac ggagaaatca
     6841 caggttacaa tcagtacaat caggcagtat ctgccgacgg ttattcttcg gagacgaagt
     6901 tgactatcac cgtcaatgta cgttttgtca acaataccaa tcatgccgaa gactttgaac
     6961 aacagttttc tgcgttccgt acctacgact ctacccagtt gctgactgcc gtacaggacg
     7021 gattgattgc tgaaatgtct aaagagatca ccgaccaaat ttttaatgca actgtagcaa
     7081 actggtaata taaatgactt ctgttaactt tcaacaatgg attcagcatc ccgagacgct
     7141 gaatagggat actttgtacg aattgcgcaa tcttcttgcg aggtatccgt attttcagtc
     7201 gcttcgtctg ctgtatctga agaatctgta tattctccat gatattagtt ttggtggaga
     7261 actgcggaaa gcagttcttt acattgcaga cagacggcag ttgttccggt tgattgaagg
     7321 tgaccgctat gatgtgcagg cacggaaaaa gggagtacct ctcacggagg tactgaaaga
     7381 cgaaccgtcc gtagaccgca cattagcatt gatcgacgct ttcttgtcca cagtacccga
     7441 agaggtgact gcccgcacca gcttcgacta ttcgatggat tacacctctt atcttttgga
     7501 ggggactccg gccacggaac agtcggccga agaaacgccc aaactcaaag gctacgaact
     7561 gattgacgac tttatagaaa agagcgagag cgactctccc ctctgcatga aacctttaag
     7621 agaagaaatg ccatcttcgc caacctcttc ggacgaactt accgaagaag aaacgatgaa
     7681 ggaagaagag gaagatgaca gctgttttac ggaaactttg gcaaaaatct atgttaaaca
     7741 gcaacgatat tcaaaagctc ttgaaataat taaaaaatta agcttgaaat atccaaaaaa
     7801 aaatgcttac tttgcagacc aaatcagatt tttggagaaa ttgattatta acgctaattc
     7861 aaaataacta aaaatgtact tattattcgt tatcttaatg gttattgcag ccttgttgat
     7921 gtgtttcatc gtgctgattc agaactcaaa aggaggcgga cttgcttctg gtttctcttc
     7981 atctaacgcc atcatgggcg tgcgcaagac tacagatttt ctggaaaaag caacatgggg
     8041 cttagctatc ttcatggtgg taatgagcat tgctactgct tatgtagttc ctcgctctgc
     8101 tgttgctaaa gacgcagtgt tggaacaggc acagaaagaa caacagacta acccgtataa
     8161 cttacccgca ggtacggctg cgccgcaaac tgaagctcct gctaccaatg cacctgctac
     8221 agaaactccg gcaccggcta ctgaaactcc tgctcctgca gcagagtaat tcactccgtc
     8281 gtcaggtaag actttggggt aaaaccatta atgggaaggt gcagacggat gctgcatttc
     8341 tttgatattt aagtgcggat tacgcagatt acacggattt tcaatgttcc gcgtggtcag
     8401 tgtaatccgc acttaacttt ttcttgtaaa aacaatctct ttgtgataga aacaaacgag
     8461 atttaactac ctttgttggc tgtataagat tattaactac ttttttaaat ataacaatga
     8521 cagaacattt gaaacagaaa ttgaatgact ccgccgtact ccgatggagt gttctagcat
     8581 tggtcgcatt tactatgcta tgcggctatt tcctcaccga cgtaatgtct cctctaaaac
     8641 ccatgcttga gaaagaacta ttatgggata gtcttgatta tggattcttc acaagcgctt
     8701 acggttggtt taacgtattc ttgttgatgc tgatcttcgg tggtatcatt ttggacaaaa
     8761 tgggagttcg tttcaccgga atgggagctt gcttattgat ggtgtttggt tgtggattga
     8821 aatactatgc gatttctact acttttccgg aaggtgccat gctcttcgga ttcaaaacac
     8881 aggtgacgtt ggctgcattg ggatatgcta tctttggtgt aggtgtggag attgctggta
     8941 tcactgtttc caagattata gtgaaatggt tcaagggcaa ggaaatggca ttggctatgg
     9001 gacttgaaat ggctacggca cgtattggga caactctggc gatggtgttg acagttcctt
     9061 tggcagactt cttcggatat acggacgagg gtggtgcatt ccataccaat attcctgctc
     9121 ctattctgtt ttgtctgatt atgctgtgtg taggtactat tgctttcttc ctttatactt
     9181 tctacgataa gaaattggat gcttctttgg atgcagaagg tttggaaccg gaagaaccgt
     9241 tccgtatgaa agatattgtg tatatcatta ccaataaggg attctggttg atcgcattgc
     9301 tgtgcgtatt gttctactcg gccgtcttcc cttttatcaa atatgctgcc gacttgatgg
     9361 tgcagaaata taatgtagat ccgaaactgg cgggaacgat tcccggattg ttgccgattg
     9421 gtgcaattat cctgactccg ttgttcggtt cgttatatga ccgtatcggt aaaggagcca
     9481 cattgatggt gatcggatca ttgatgctaa tttttgtaca taccatgttt gccctgccta
     9541 tactgaatat atggtggttt gctactatta taatgattat attgggattt gctttctcat
     9601 tggtgccttc ggctatgtgg ccttctgttc cgaagattat tccggaaaaa cagctgggta
     9661 ctgcttacgc tttgattttc tgggtacaga actggggact gatgggtgtt cctttgttaa
     9721 tcggatgggt attgaatact tattgcaaag gtccggtggt agacggtgca cagacttatg
     9781 attacacatt gccgatgact atttttgctc tctttggtgt acttgctctg attgttgctt
     9841 tgatgttgaa agcagagaac aagaagaaag gatatggttt ggaagaggca aatatccaga
     9901 agtaacagtt acaattcgaa gtaacgttat aaatccgaga gtataaggtt tgaaaataaa
     9961 agagggttag tattaatgct ctgaaataaa aaaaagaatt atggctgcca aagagaaaat
    10021 caacctgtta gaggtcattc cctgtcgcag tgaacatatt acagcagaaa gggaagggga
    10081 gacgattgtg ctctcctttc cccgttttaa atatccgtgg atgcaacgct tccttgtacc
    10141 ggcaggaatg tcgaaagaac ttcatgtgcg attggaagaa cacggtacgg ctgtatggga
    10201 actgatagat ggaaaacgta ctgttcgtga aatcatagaa gaactcgcag attattttca
    10261 aaatgaagcg ggatacgagt ctcgtgtatc ggcttatctt tctcaaatgc agaaagatgg
    10321 gtttataaaa ctttttatta attgacttta ttagatgata ggtgataaat gatagttact
    10381 atgcggcata atagctagtt atatgatagt gcagcctcct aaggaggttt atcaaatatc
    10441 ctgtttaaag atatgaaaaa aggcaactga ttcgtaatga tgtagttgcc tttttagtat
    10501 tttgagaata tctttagtta cttatatttc ttatttactg aatatccctt atcatttagg
    10561 aagcatctcc catctatcat ttatcaacta tcatctaata aattatctaa ttaaggaaaa
    10621 tagcccagaa tatcacggca gttgcaatga ggacccccat gataataagc gtcccccaaa
    10681 cgaaataatt gctgtccttt tctttctttt tctccgagtc gtggatgata cgtcccattt
    10741 cctcgggagt ggtgttgggc agtggataag gctcgttggt gcggtttaag tgcttcagtt
    10801 tgtcgttggc acgttcacgg cgtagacggg aagcctctcg cccttcgcta agccgacgta
    10861 tcatgtcgag catgtgtcct tcaccaccca tattctttgc cctttagaag tttactattt
    10921 gccttcttct ctatccactt ttaacaatcc tcccgtattc ggatcaaaat aaactttgat
    10981 tgtagaattc ttattgaata agacaggagc cagatattct atcacaccga attgagtaat
    11041 agggagttca ccttcgtaaa gtttcttttt accgtcggtc aatgtaacca ttgcttgtcc
    11101 gggcacgttg taggcgattc catccaaatc tttcttcttc ttaccgtctt cctgtgggat
    11161 cttgactgat ttcaggtctt tcaagctgat ataaaacgga gttcctgcta gatcattgtt
    11221 ggcaactaca cccagtttct tggagaagcg gaaagcaact tcgttgttga attccctgtc
    11281 tggagtaagg cggacggtga atgtcttctc ttccttatca cgagtgccgg agaacatttg
    11341 cgtcattgct tcttcctgtg cattcagatt atcaagcata attttaagct gtgctccgtc
    11401 tgaaggcata ttgtcagctt gtccgcgcaa taaggcattc ttgctttcgc ggatgttata
    11461 gatctcttta gccaccagtt cagccatctt cgcggtagag ctggccatca gaatttcttc
    11521 ggttaggaat tcgcggggat tcgctatttt tgagaggaca gtgggagcag gagctgtttt
    11581 cttgtctgaa ctgctgttgc tgtaaggaac attgatcgtt ttcacaatgc catcctctgt
    11641 cagttccatg agcggtgcta ctgtcttatc cttcaatttt acgaaatacg tcgtttcgct
    11701 gttgggcaca cctacggatt tcacttttac gctagtcagt tcccagtact cttcagggtc
    11761 ggcggagacg ttggtcagtc gcaggtaacg atcagcatat ttgctgaatt ctcccggagt
    11821 atagttgact ttgttggctt ttatttcaag ttctatttgg gttttgggaa gactgtaaac
    11881 cactccatag tcttttcctc gggtaacccc tgtcagtact tcggtttgtg cataggcgga
    11941 cgttgtcata agtagtcctg ctgctataat caactttttc atattcggtt ctttttaact
    12001 ggttttgaaa acaaagttaa tgaagttatt gaaaaaactg taagttctta acttttattc
    12061 gcttacaagt cgccatgctg tcggcagaca ggtgataata tcgcttgcga tcattccgat
    12121 cattccttgc ttcttttgag cgacatcgcc cgccaatccg tgaatgtaag tgccgatttt
    12181 agcggcttct tcggtgggat aaccttgggc aagcagcgcc aggattactc cggtcagtac
    12241 gtcaccgcta cctccggttg ccattcccgg atttccggtt gggttgaaga aacatttacc
    12301 ttcgggggtg atgatggcgg agtaggctcc ttttaaaata atgtggacat gggcggcacg
    12361 ggccagttcg caagccttca tcagacgttc gtaagagtcc tggcatttgc cggtcagacg
    12421 ttccagttct ttcggatgcg gggtgaggat ggaacccttc ggcagatggg taagggcatg
    12481 acggtggttg gcgaggatat taagagcgtc ggcatctact acaacaggag tctggcagtg
    12541 ttccagttgt tccaataagg cagcttccgt ttcctcgttt cgtcccagtc ccgggccgat
    12601 gccgactgct tgatagtcgt ccgtgtcggt aggtacggta aaacaggttt cgttgatgtc
    12661 ggtttctacg attgcttcgg gtatggaggt ctgcaagatg tcgttgttgc acattggcgc
    12721 atgaacagtc agcagcccta ctcccgaacg gaggcaggcg cgggcagcga gaacagaggc
    12781 tcctgccatt ccttttgaac cggcaatcaa tagtgcatgg ccgaagttcc ccttgtgggc
    12841 aaactgtttg cgtggcttga tgagtgaacg gatttcttct atttccaaca tttcgtagtt
    12901 agtctccatc tcttcaatac cgtcttcgct taattggata tccagcactt cccattctcc
    12961 gacaaattca gtgttctctg cgaaaagaaa ggcgagcttc ggcagttgca gactgaaagt
    13021 tacgtcggca cggataatat tagcttttac gttgaatgta ttttcttctc ccatcagtcc
    13081 ggaaggaatg tcgatggcta ctaccatggc aggggaggaa ttgatgtatt tcactacggc
    13141 agcgaatcca ccgctcaacg gtttgttcag gcctgaaccg aataatccgt cgattaccag
    13201 atgatcgggc gtcaggacgg gaggtacgaa ttgggtactg atttcgtgga attttacttc
    13261 ttccatcatt tctaccagtt ctttattggt ctggcagtcg ggtgaaagtt ctcctttcgt
    13321 gttgaagaga aatacctcga ttttatatcc tttttcagcc atcatgcggg ctacggcgag
    13381 agcgtctccg ccattattcc ccggtccggc aaagatagtg accggcgttt ccgtattcca
    13441 tctgtctgtg atggcttttg ttaatacggt tgctgcacgt tccatcagat cgattgatgc
    13501 aataggttcg ttctcaatgg tataagcgtc caatttcttg atactgctgc ttggaaatat
    13561 tttcattgcg atgttctttt agttttcgga ttacaaatgt acatgattct tctgactttt
    13621 cccgtttgtt gtgggaagaa aaccataatt gcaactttta attcatcatt agttctatct
    13681 tttggtcaaa gaaatatctg cttttgaact attaagtgtt agaataactc cgccaaaaaa
    13741 taattcaatg ctgcaccatt atgaacttac ttttatttct ccctgaaaaa gatttcaggt
    13801 tcttcgtcaa atttggtggt aatctctttt ttatttcgac ggttt
//
