LOCUS       c00042_gnlPro..        15329 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ADMMJENN_69.
ACCESSION   c00042_gnlPro..
VERSION     c00042_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 18:05:27
            Original ID  :: gnl|Prokka|ADMMJENN_69
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15329
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15329
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[469:5329]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      470..5329
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..15329
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15329
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             23..385
                     /locus_tag="ctg42_1"
                     /transl_table=11
                     /translation="MIQVRIKRVYEDFSETDGYRVLVDKLWPRGMKKEWLKYDYWAKDI
                     TPSSTLRRWFHEDIPGHWEDFVIQYQKELDASSSMADFLTLIKPHPVITLLYASKEPVY
                     NHARILRDYLEMRLKE"
     CDS             470..1702
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg42_2"
                     /sec_met_domain="HBT (E-value: 2.8e-17, bitscore: 56.5,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYKLLVLDVDGTLLNDAKEISKRTLAALLKVQQMGVRIVLASGR
                     PTYGLMPLAKMLELGNYGGFILSYNGCQIINAQNGEILFERRINPEMLPYLEKKARKNG
                     FALFTYHDDTIITDSPENEHIQNEARLNNLQIIKEEEFSAAVDFAPCKCMLVSDDEEAL
                     VGLEDHWKRRLNGALDVFRSEPYFLEVVPCAIDKANSLGALLEVLDMKREEVIAVGDGV
                     CDVTMIQLAGLGVAMGHSQDSVKACADYVTASNEEDGVAVAVEKAIIAEVRAAEIPLDQ
                     LNAQARHALMGNLGIQYTYADEDRVEATMPVDHRTRQPFGILHGGATLALAETVAGLGS
                     MILCQPDEIVVGMQVSGNHISSAHEGDTVRAVGTVVHKGRSSHVWNVDVFTSTNKLVSS
                     IRVVNSVMKKR"
     CDS             1699..2814
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg42_3"
                     /sec_met_domain="Chorismate_bind (E-value: 7.7e-57,
                     bitscore: 186.3, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDEEISNLTTIDAFIQRKQPFAVYRIPGEKVPRLLTQAEGAVRL
                     IYDLKELNGQRGFVIAPFQVSESCPVVLIQPDQWGQPLPVDDDTEEDREIALRLQGQES
                     FLTSSTEEYAACFHTFINALRDRTFDKLVLSRHLTVDKVADFSPLSIFRAACKRYIHSY
                     IYLCYTPQTGIWLGSTPEIILSGEKDEWHTVALAGTQPLQDGRLPQVWDEKNRKEQDYV
                     ASYIRRQLLSLDIHSTENGPYPAYAGALSHLKTDFRFSLKDNKGLGDLLKVLHPTPAVC
                     GLPKEEAYQFILQNEGYDRRYYSGFIGWLDPEGRTDIYVNLRCMHIEDKQLTLYAGGGL
                     LASSELNDEWLETEKKLQTIKRLIAVPPLKS"
     CDS             2834..4501
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg42_4"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.9e-06, bitscore:
                     21.3, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYTDKKNILQLVALLEAHGITKVVLCPGSRNTPIVHTLSNHPNFT
                     CYPVTDERSAGYFAIGLALNGGKPAAVCCTSGTALLNLHPAVAEAFYQNVPLVIISADR
                     PAAWIGQMDGQTVPQPGVFQTLVKKSVNLPEIHTEEDEWYCNRLVNEALLETNHHGKGP
                     VHINVPISEPLFQFTVDSLPEVRVITRYQGLNVYDRDYNDLVDRMNKYQKRMIIIGQMN
                     LIYLFEKRYIKLLYKHFAWLTEHIGNQTVPGIPVKNFDAALYAMPEEKVGQMVPELLIT
                     YGGHVVSKRLKKFLRQHPPKEHWHVSPDGEVVDLYGSLTTVIEMDPFEFLEKIASLLDN
                     RTPEYPRVWENYCKIIPEPEFAYSEMSAIGTLLKALPESCALHLANSSVVRYAQLYSIP
                     STIEVCCNRGTNGIEGSLSTAVGYAAASDKLNFIAIGDLSFFYDMNALWNVNVRSNLRI
                     LLLNNGGGEIFHTLPGLDMSGTSHKFIAAVHKTSAKGWAEERGFLYLQAQNDEELAEAM
                     KTFTQPEAMEQPVLLEVFTNKNKDARMLKNYYHQLKQK"
     CDS             4505..5329
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg42_5"
                     /sec_met_domain="ECH_1 (E-value: 1.7e-81, bitscore: 266.7,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTQREWTTIREYDDILFDYYNGIARITINRERYRNAFTPTTTAE
                     MSDALRICREEADIDVIVITGAGDKAFCSGGDQNVKGRGGYIGKDGVPRLSVLDVQKQI
                     RSIPKPVIAAVNGFAIGGGHVLHVVCDLSIASENAIFGQTGPRVGSFDAGFGASYLARV
                     VGQKKAREIWFLCRKYNAQEALDMGLVNKVVPLEQLEDEYVQWAEEMMLLSPLALRMIK
                     AGLNAELDGQAGIQELAGDATLLYYLTDEAQEGKNAFLEKRKPNFKQYPKFP"
     CDS             5502..6527
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MR_MLE_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg42_6"
                     /sec_met_domain="MR_MLE_C (E-value: 3.1e-27, bitscore:
                     89.1, seeds: 401, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNCKIEIIPRLLHFKQPAGTSRGTYTTRKVWYLHFTSPDFPGRVG
                     IGECAPLPALSCDDLPDYEDILVKVCRKVEREQGRLDMDGLCDYPSILFGLETAIRHFF
                     AGNWALCDTAFSRGEVGIPINGLIWMGDFQNMLSQIEKKMEAGFRCIKLKIGAINFEEE
                     LTLLRHIRTHFSSKEIELRVDANGAFSPVDAMEKLKRLSEFDLHSIEQPICAGQWEEMA
                     RLAAESPLAIALDEELIGCNTLERKQELLSTIRPQYIVIKPSLHGGICGGDEWITEAEK
                     QQIGWWITSALESNIGLNAIAQWCATFSNPLPQGLGTGALFTDNVEVPLEIRKDCLWFC
                     K"
     CDS             6579..10613
                     /locus_tag="ctg42_7"
                     /transl_table=11
                     /translation="MAILAADKDKEIKTLFLKYMAWNMLPLLYNDALKKLCKMGFSPAK
                     ATKLLKSMQENGEIEIVSNLHYFGNKRCRLLPGIHLRYLWLMRNESFEEFEKEQSLPGY
                     IELQARTLCNAMLQWAATKELDNDIITHWPVDELTLPLFREMAYSTEWRDLYSKLSVGV
                     LYCIIDGYANRWNYWLEEIDELFVENLYLRNQSMPTSVKAYFREVYSFYEYVLSGRINE
                     IPENVTSRSVDGLCAHALYAQYHGNYSEALKIYRQALKDIESTYLFDTPFYSLTYVIAL
                     MREGSEASKKKMSGLVTKKRIREERQWLPAYLMLLIALGRDTKELVLWIERNYDLQSNM
                     VKALLYLLLEHYKLNEKIYIDNRPIEKLLENDRFKALQLEYSCDFQAFISKNAQLREEM
                     GVAPLLPSYAKQEPWEIALDRLAELVRNQETREVAKGAADNIARSRIVYHITNYGQIIP
                     RLQKSKDGITWTGGRNIALATFQQNAVEGMSELDKSLAACVKYFNAGYSIGDIYELSGP
                     KALSLLAGYPFVYMERNPDIPIVITKEELQLVVTQLKDGYQVSSNVKQLGSSNTILNKE
                     NDQLYRIVELTSEQRAILELFKQSSRFPLKAKDQLADVLGKLGRNVTIHSDLVRNKENL
                     KQIKGDSLITVQLLPVGDGIKVELFVKPFIEQPPYCKAGEGVGSVIGTMKGERVQAVRN
                     LKKEKENYVIVNQLLQRVSGDFMATDTAYFADYYQCLDLIEELRELSDVSRTEWPEGAK
                     LSIKGIADFPQLKLSMKGVGYWFEIDGELEIEDGVRMKISELLRKTRESRGRFIALNDS
                     DFIALSNQLRRKLQELDSILLNDKSLKVSSFNATLLADMEQQGILLKKDHKFKELQQKI
                     EQAENVRFIVPATLQAELRDYQMDGFRWLSRLAYWGAGACLADDMGLGKTIQAIALMLS
                     RGKKGASLVVAPASVLLNWQSEINRFAPSLTCRVLHDSCGDREQMIQETGDYDILLTTY
                     GLLNAEVVLLSKKQWNVILLDEAHTIKNKDTKMSKAAMQLNGEFRLLLTGTPIQNHLSE
                     IWNLFQFANPGLLGTFPHFNEKFILPIEKNGDKQRQKQLKRVLQPFLLRRTKNEVLDEL
                     PQKTEIVQKVELSSEEMALYENLRQQAVANIEESSLGAMQALAEITRLRQAACHPALIN
                     DKLKIDSSKTKVFMDLVDELIGNQHRALVFSQFTSHLALIRKELDLQGISYLYLDGTMS
                     VNEREKQVSRFQQGEGHLFLISLKAGGTGLNLTAADYVIHLDPWWNPAVEDQASDRVYR
                     IGQTRPVTIYRLIASNTIEEKIVTLHQSKKSLADSLLDGSNMAHKLTKEEMLELLRGGI
                     Q"
     CDS             10615..11706
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 55.9; E-value:
                     9.4e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg42_8"
                     /sec_met_domain="AMP-binding (E-value: 2.8e-17, bitscore:
                     55.9, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFEREKQSLLLEGVRYTANDLHLLKTKAVGASDSSTGQMLYDFL
                     QEWFTESPWMTVHTSGSTGKPKKIRISKDKMMQSARLTCEFLNLQIGDTALLCMNLRYI
                     GAMMVVVRSLVAGLNLIIRPASGHPLADMKQPLRFAAMVPLQVYNTLQVPEEKERLRQT
                     DVLIIGGGAIDEALEAEIRNLPGAIYSTYGMTETLSHIALRRLNGVLASERYYPFASVE
                     LSLSSENTLVIKAPLVCDDILQTNDIAHIYPDGSFTILGRKDNVINSGGIKIQAEEIEK
                     ILRPYIPVPFVITSVPDQRLGQAVTLLLEGQPDIEEIEDKLQSILEPYHRPKYVLYTDC
                     IPQAGNGKMNRAGCRDLAERLLS"
     CDS             complement(12475..13038)
                     /locus_tag="ctg42_9"
                     /transl_table=11
                     /translation="MKISFSKQTKERTFKQLYEEYYAPFCLYAKRFVDDKETREDIVSD
                     VFTSLWDKFETESFDLQSDTALGYIKMCVKNSCLNFLKHQEYEWSYAENIQKKAPIYET
                     EPDSVYTLDELYRMLYETLNKLPENYRTVFMKSFFEGKTHAEIAEEMNLSVKSINRYKQ
                     KTMELLRNELKDYMPLLLLLLPYQ"
     CDS             13212..15203
                     /locus_tag="ctg42_10"
                     /transl_table=11
                     /translation="MKNKFFLLAITFCLPIHPQEVSKSFIPMVEIPAGSFYMGSDGLGE
                     DFDEAPIHQVVISRPFRMGITEITNAQYESFRPEHRALRGKNGVSLEDDEAVVNVSYSD
                     AVAFCEWLSRKEGKNYRLPTEAEWEYACRAGTYTLFSTGDGLPAVYHRNQKVVRDFDPV
                     SLKVAQTPPNTFGLYDMHGNVEEWCLDWYASYSAEKQKDPAGPLAGEFRVTRGGSHHTP
                     EKYLRSANRLAMLPEDKHSQTGFRIVEADTRLNVSGTSAPVPFNQESVKNTSIKWKKVS
                     AITPMFLPPIPFVVRPACDSNTPFYLHNHQPAVTWCDNGDLLAIWFSANEENGRGMVVL
                     GSRLRAGHTDWDVASLFFKVPDRNMTGSALLNDGKGKLYHINGMEASGDWQNLAMVLRT
                     STDNGASWSTPKLIAPEHTKRHQVIAGTIRTREGWLVQACDAGPGSHDGAAVQISKDGG
                     KTWCDPWDGAPLPDFKEGGTGSTIAGIHAGIVQLGNGSLMAMGRGNSIRNKEGKLRMPM
                     SISDDMGKTWKYVASELPPIDGGQRLVLMRLNEGPLLLVSFTDHPQRTPLEERGLEFKD
                     KNGNVKKGYGMYAALSYDEGKTWPVRKLLTDGEYRFLNGGAWTGYFEMDENHAEPRGYL
                     AGTQTPDNVVHILSSRLHYRFNLAWLEK"
ORIGIN
        1 ttataattaa ctataaatag aaatgataca ggttaggata aagcgggttt acgaagattt
       61 ttcagaaaca gatggctacc gggtactggt agataaatta tggccacgtg gaatgaagaa
      121 agaatggctt aagtacgatt attgggcaaa agacatcaca ccgtcttcca cattgcgtag
      181 atggtttcac gaagatattc ccggacactg ggaagacttc gtcatacagt atcagaaaga
      241 acttgacgct tcttcctcaa tggctgattt tctgactctt atcaagccgc atccggtgat
      301 aacattgctt tacgcttcca aagaaccggt gtataatcat gcccgtatcc tccgcgatta
      361 tctggaaatg cgtttgaaag agtgaaatta aagtaatttt tatctgttta cgctttctgt
      421 cgttcactca atttcctacc tttgtaatct aaatcaaaat cgtgtaatca tgaagtataa
      481 attattggtt cttgatgtag acggaacact cctcaatgat gcgaaagaaa ttagtaagcg
      541 tacattggct gccctgttga aggttcagca aatgggagta cgtattgtgc tggcatccgg
      601 cagaccgact tatggcctga tgccgttggc caagatgctc gaacttggaa actatggagg
      661 ttttatcctt tcctataatg gctgtcagat tatcaatgca caaaacgggg aaattctgtt
      721 tgaacgtcgg attaatcccg aaatgttgcc gtatctggaa aagaaagccc gtaaaaacgg
      781 ttttgcctta ttcacttatc atgatgatac gattataacg gattctcctg aaaatgaaca
      841 tatccaaaat gaagcccggt tgaataacct gcaaataatt aaagaagaag aattttctgc
      901 tgccgttgat tttgctcctt gtaagtgtat gctggtgagc gatgacgaag aagcactggt
      961 tggtttggaa gatcactgga agagacgact gaacggagcg ttggacgtat tccgttcgga
     1021 gccatatttt ctggaagtag ttccctgcgc catcgacaaa gccaactctt tgggcgcttt
     1081 gctggaggtg ctggatatga agcgtgagga agtgattgct gtaggcgatg gtgtgtgtga
     1141 cgtaacaatg attcaattgg ccgggctggg cgtagctatg ggacattcac aagactcggt
     1201 gaaagcctgt gccgactatg tgaccgcttc gaatgaggaa gacggagtgg ccgttgcagt
     1261 ggagaaggct attatagctg aagtgcgtgc tgctgaaatt ccccttgacc aactgaatgc
     1321 gcaggcacgc cacgcattaa tgggaaactt gggaattcaa tatacatacg ccgacgaaga
     1381 ccgtgtggaa gcaacgatgc cggtagacca tcgtacccgt cagcctttcg gcattttgca
     1441 tgggggagct actcttgcgt tggcggaaac agttgccgga ctcggttcga tgattctttg
     1501 ccagccggac gagattgtag taggaatgca ggtcagcgga aaccatatat cttctgcaca
     1561 tgaaggagat acagtgcgtg cggtaggaac agttgtacat aagggacgtt cctcccacgt
     1621 atggaatgta gacgtgttta cttcaacaaa caaactggtg tcttccatac gggtagtcaa
     1681 cagtgtgatg aaaaagagat gaccgacgaa gaaataagta acttgacaac tattgatgca
     1741 tttattcagc ggaagcagcc gtttgctgtt taccgtattc ccggagagaa agttccccgt
     1801 ctgttgacgc aggcggaagg agcggtccgt ttgatatacg atttgaaaga actgaatgga
     1861 cagagaggat ttgtaattgc tccgtttcag gtgagtgagt catgtccggt tgtgttgatt
     1921 caacccgatc agtgggggca gcctttaccc gtggatgatg atacggaaga agaccgggag
     1981 atagccttgc gcctgcaagg acaagaatca tttctgactt cttctacgga agaatatgcg
     2041 gcatgctttc atacctttat aaatgcgtta cgtgacagga cgtttgataa actagtgctt
     2101 tcccgtcatc ttacagttga taaagttgcg gatttttctc ctttgtccat ctttcgggcg
     2161 gcttgtaaac gttatattca ttcgtatatt tacttatgtt atactccgca gacgggcatc
     2221 tggctgggaa gtactcccga aatcatttta tcaggtgaga aagacgaatg gcatacggtt
     2281 gcactagccg gaacacagcc tttgcaagat ggcagattgc cgcaagtatg ggatgaaaag
     2341 aaccggaaag aacaagatta tgttgcttct tatatccgtc ggcagcttct ttcactggat
     2401 attcattcta cggaaaacgg gccatatcct gcttatgccg gtgctttgtc acatttaaaa
     2461 actgatttcc gtttttcttt gaaagataat aaaggtttgg gagaccttct gaaagttttg
     2521 catccgacac ctgccgtatg cggcttgccg aaggaagaag cctatcagtt tattttgcag
     2581 aatgaaggtt acgaccgccg ctattactcc ggctttatcg gatggctcga tccggaagga
     2641 cgaacagaca tctatgtaaa cttacgctgt atgcatatcg aagataaaca acttactctt
     2701 tatgccggcg gtggattatt ggcctcttcg gaattgaatg acgaatggct ggaaacggag
     2761 aagaagttgc aaaccatcaa acggctgatt gcagtgcctc ctttaaaatc ataaactact
     2821 aataattatc atcatgtata cagacaagaa gaacatactc cagttggttg cgttgctcga
     2881 ggcgcatggg attactaagg ttgtattgtg tccgggtagt cgtaatacgc ccatagtaca
     2941 tactttgtct aaccatccga attttacctg ctatccggtg acggatgaac ggagtgccgg
     3001 ctattttgcc atcggtcttg cgttgaatgg tggtaagccc gcagctgtct gttgcacttc
     3061 cggtactgca ttattaaacc ttcatccggc tgtggcagaa gcattttatc aaaatgttcc
     3121 tctggtcatt atttctgcgg atcgtcccgc tgcctggatc gggcagatgg atggacagac
     3181 agtaccacaa ccaggcgtat ttcagacatt ggttaagaag tcagtaaacc ttccggagat
     3241 tcatacggaa gaagatgaat ggtattgcaa tcgtctggtg aatgaagctt tgctggaaac
     3301 gaaccatcat ggaaaaggac cggtacatat taatgtccct atttctgaac cgttgttcca
     3361 gtttacggtt gattcgcttc ctgaagtgcg tgtcattacc cgttatcagg ggttgaacgt
     3421 ctacgatcgt gattataatg atttggtcga tcggatgaat aaataccaga agcgaatgat
     3481 tatcatcggt cagatgaatc ttatctacct gtttgaaaaa agatatatca agttattata
     3541 taaacatttt gcctggttga ctgaacatat cggcaaccag acagttcccg gtattccggt
     3601 aaagaacttt gatgcggcgc tttatgccat gcccgaagag aaggtcggcc agatggttcc
     3661 ggagttgttg attacttatg gaggacatgt cgtttccaaa cggctgaaga agtttctccg
     3721 tcagcatccg cctaaagaac attggcacgt atcgccggat ggtgaggtgg tcgatttgta
     3781 cggctcatta actacggtga tcgaaatgga cccgttcgag tttctggaga agatagccag
     3841 tttgttggac aatcggactc ctgaatatcc ccgtgtgtgg gaaaactatt gcaagatcat
     3901 tcccgaaccg gagtttgctt attcggaaat gtctgccatc ggtacgttgt tgaaagcctt
     3961 gccggagtca tgtgcgttgc atctggctaa cagttcggtg gtgcgctatg cacaattata
     4021 ctctattcct tctacgattg aagtttgttg caaccgggga acaaacggta ttgaaggctc
     4081 gctgtctacg gctgtcggtt atgcggcagc ttccgacaaa ctgaacttta tagctatcgg
     4141 agatttgagc ttcttttatg atatgaatgc gttgtggaat gtcaacgttc gctccaatct
     4201 gcgtatcctt ctgttaaata atggaggagg agagattttc cataccttgc cggggttgga
     4261 tatgtcgggt acttcgcata aatttattgc ggcagtccat aaaacgtccg ccaaaggttg
     4321 ggcagaagag cgtgggtttc tttatctgca agcgcaaaat gacgaagaac tggctgaagc
     4381 gatgaaaact ttcactcaac cggaagctat ggagcagcct gtgctcttgg aggtgtttac
     4441 caacaaaaac aaggacgcgc gcatgttgaa aaattattat catcaattaa aacaaaaata
     4501 gattatgtca acacaaagag agtggacaac catcagagaa tacgacgata ttctttttga
     4561 ttattataat ggaattgccc gtatcacgat caaccgtgaa cgctatcgga atgcgtttac
     4621 tccgacaact actgctgaaa tgagtgacgc attgcgcatc tgccgtgaag aagcggatat
     4681 tgatgtgatt gtgattaccg gagccggtga taaggcattt tgttcgggcg gcgaccagaa
     4741 tgtgaaagga cgtggcggat atatcggaaa agacggtgtg cctcgtctta gtgtattgga
     4801 tgtgcaaaag cagattcgca gcatcccgaa accggtgatt gctgccgtga acggttttgc
     4861 tattggtggc ggacatgtgc ttcatgtggt atgtgatttg tccattgcgt cggaaaatgc
     4921 tattttcggt cagacgggtc ctcgtgtagg tagctttgat gccggattcg gtgcgtctta
     4981 tctggcacgt gtggtcggtc agaagaaagc acgcgaaatc tggttccttt gccggaagta
     5041 taatgcacaa gaagcattgg atatgggatt agtgaataaa gtagttccct tggagcagtt
     5101 ggaggacgaa tatgtacagt gggcggaaga aatgatgttg cttagtccgt tggctttgcg
     5161 catgattaaa gcaggattga atgccgaact ggatggtcag gcaggtattc aggaattggc
     5221 aggtgacgca acgttgctct attacctgac tgatgaagca caggaaggca agaatgcgtt
     5281 tctggagaaa cgtaaaccga acttcaaaca atatccgaaa ttcccttaaa atcggctttg
     5341 ccacagagta ccacagagtt tgcttttcct gcgtttaagc ccgattttct gcaaagcaag
     5401 actgtggagg agagaatggt aggagaactg caagagatat aacttattaa aacttcgtga
     5461 ggctctgtgt tattctgtgg tgaattgaaa aattattcac gatgaattgt aaaatagaaa
     5521 ttattccccg attgctccat ttcaagcaac ctgccgggac ttccagagga acatatacta
     5581 cgcgtaaagt ttggtatctt cattttacct ctcctgactt ccctggcaga gtgggaatag
     5641 gggagtgtgc acctttgccc gctttaagtt gtgacgatct tcctgattac gaagatatat
     5701 tagtgaaagt ctgccggaaa gtagagaggg aacaaggcag attggatatg gatggcttgt
     5761 gtgactatcc ttcaatttta tttggtctgg aaacggccat ccggcatttc tttgcaggaa
     5821 actgggcttt atgtgatacg gctttctcac gtggagaagt tggtattccg attaacggcc
     5881 ttatttggat gggagatttt cagaacatgt tatcccagat tgagaaaaag atggaagccg
     5941 gatttcgttg tatcaagtta aagataggtg ccatcaattt cgaagaagaa ctgacattgt
     6001 tgcgccatat tcgtacgcat ttctcttcta aagaaataga gttgcgtgta gatgcaaatg
     6061 gtgctttctc acccgtggac gcaatggaaa aactgaaacg tctgtccgag tttgatttac
     6121 attctatcga acagccaatc tgtgccggac aatgggagga aatggctcgg cttgctgccg
     6181 aatctccatt agcgattgct ttggatgaag aactgatagg atgcaatacg ctggaaagga
     6241 aacaggagct gctttcaaca attcgtccgc aatatatcgt tattaaacct tctcttcatg
     6301 gaggaatatg cggaggagac gaatggatta ccgaagctga aaaacaacag atcggctggt
     6361 ggataacttc cgctctggaa tcaaacattg ggctaaacgc cattgcccag tggtgtgcaa
     6421 cattcagcaa tccgttgcca cagggactgg gaacaggggc gctctttaca gacaacgtgg
     6481 aagtgcctct tgaaataaga aaagattgcc tgtggttttg taaatgatgg tgttaaagga
     6541 taatcgactg gtaacgacaa aacatagaac taaaaaagat ggcaatatta gctgctgata
     6601 aagacaaaga gattaaaacc cttttcttaa aatatatggc ttggaacatg cttccattgc
     6661 tatataacga tgcattgaag aaactctgta agatgggatt tagccctgcc aaggctacta
     6721 agttgctgaa gtcaatgcaa gagaatggcg agatagaaat cgtttcaaac ctgcattatt
     6781 tcgggaataa aagatgtcgg ttgctgcccg gcatccatct ccggtattta tggctgatgc
     6841 gaaatgaatc gtttgaagaa tttgaaaaag aacaatctct ccccggatat attgagctgc
     6901 aagcgagaac attgtgtaat gcgatgttac aatgggctgc gacgaaggaa ttggataatg
     6961 atataataac gcattggccg gtagacgaat tgacactgcc tctatttcgt gaaatggcat
     7021 attctaccga atggcgagat ttatacagta aactttctgt cggtgtttta tattgtatta
     7081 tcgatggata tgccaatcgt tggaattact ggctggaaga aatagacgag ctttttgttg
     7141 aaaatctata tctaaggaat caatcaatgc ctacttccgt taaagcgtat tttcgggaag
     7201 tttattcatt ttatgaatat gtattgtctg gtcgtatcaa tgaaatcccg gagaatgtaa
     7261 cgtcccgctc tgtggatggt ttatgcgccc atgcgcttta tgcccaatat catggaaatt
     7321 attcagaggc acttaaaata tatcggcaag ctctcaaaga tatagaaagt acctatcttt
     7381 ttgatacgcc tttctattcg ttaacgtatg tcatagcatt aatgcgcgag ggtagtgagg
     7441 cttcaaagaa aaagatgagc ggattagtga caaagaaacg gattcgtgaa gaaaggcaat
     7501 ggctgccggc ttatctgatg cttttgattg ctttaggaag agatactaaa gaattagtct
     7561 tatggataga gcggaactat gacctgcaat cgaatatggt aaaagcatta ttgtatttac
     7621 ttctcgaaca ttataagctg aatgagaaaa tctatataga caatcgccct attgagaaac
     7681 tgcttgaaaa cgatcgtttt aaagcattgc agttagaata ttcatgcgac tttcaggctt
     7741 ttatttctaa aaatgcgcaa ttgagggaag agatgggagt ggctcccctg cttccttctt
     7801 atgctaaaca ggaaccttgg gaaattgcgt tggacagatt agcggagctg gttcggaatc
     7861 aggaaaccag agaagtagcg aaaggagccg ctgataacat agctcggtca cgcattgtat
     7921 atcatataac gaattatggt cagatcattc cccgacttca aaagtcgaaa gacggaataa
     7981 cctggacggg agggaggaat atagctttgg ctactttcca gcagaacgca gtagaaggga
     8041 tgagcgaact agacaagagc cttgcggcat gtgtcaagta ctttaatgcc ggatattcta
     8101 taggagacat ttatgagttg agcggaccca aggcgttatc tcttttggcg ggttatccat
     8161 ttgtgtatat ggagagaaat ccggatattc ctattgtaat tacgaaagaa gaactacagt
     8221 tggtggttac tcaactgaaa gacggttatc aggtgagcag taatgtgaaa cagttgggaa
     8281 gttcgaatac tattttaaat aaggagaatg atcagctcta tcggattgta gaactgacct
     8341 cggaacagcg tgccatattg gaactcttca aacaatcctc ccgctttccg ttaaaagcta
     8401 aagaccagtt ggcggacgtg ttggggaaat tgggaagaaa cgtgacgata cattcggact
     8461 tggtacgcaa taaagaaaac ctcaagcaaa taaaaggaga ttcattgata accgttcagc
     8521 tgttgcccgt aggagacgga atcaaggtgg aactttttgt aaaacctttc atcgaacagc
     8581 cgccttattg caaagccggt gagggagtgg gaagcgtgat tggaacaatg aagggcgaac
     8641 gtgtgcaggc ggtacgcaat ttgaagaaag aaaaagaaaa ttatgtgata gtcaaccagc
     8701 tacttcaacg ggtcagcgga gactttatgg ctacggatac ggcttacttt gcagattact
     8761 atcaatgtct ggatctgata gaagagcttc gcgagctgtc agatgtgtcg cgtaccgagt
     8821 ggccggaggg tgctaaattg tctataaagg gcattgcgga ttttccacaa ctgaagcttt
     8881 ctatgaaagg ggtaggatac tggttcgaga tagatggaga gttggagata gaagacggag
     8941 tccggatgaa gatttccgaa cttttgcgga aaacccgtga aagcaggggg cgttttatag
     9001 cgttgaatga ctctgatttc atcgcattaa gcaatcagtt acgtcggaag ttgcaagaac
     9061 ttgattctat cctgctgaat gataaaagtc tgaaagtttc cagctttaat gccactttgc
     9121 ttgctgatat ggaacaacag ggaatcctgc tgaaaaaaga ccataagttt aaggaactac
     9181 agcaaaaaat agaacaggca gaaaatgtcc ggttcatcgt acctgccacg ttacaggctg
     9241 aattgcgtga ttatcagatg gatggattcc ggtggttatc acgattggcg tattggggag
     9301 ccggtgcttg tctggcggat gatatgggat tgggaaaaac gatacaagcc attgctctga
     9361 tgctcagcag agggaagaaa ggtgcttctt tggttgtcgc tcctgcatcc gtattgctta
     9421 actggcagag tgaaatcaac cgttttgctc cttcgcttac ttgccgggtg ctacatgaca
     9481 gctgcggtga tcgggagcaa atgatacagg agacaggtga ttatgatata ttgcttacta
     9541 cttatggatt gctgaatgcg gaggttgtat tgttgagcaa gaagcagtgg aatgtcatcc
     9601 tgctggacga agcccataca attaagaata aagacaccaa aatgtccaag gcggcgatgc
     9661 aactcaacgg tgaattccgt ttgttgttga ccggaactcc catacagaac catctaagtg
     9721 aaatctggaa cttatttcag tttgccaatc ccggtttact ggggacattt ccgcatttta
     9781 atgaaaagtt tattctgccc attgagaaaa acggagataa gcaacggcaa aaacaattaa
     9841 agagagtgct gcaacctttt ctgcttcgac gtaccaaaaa tgaggttttg gacgaactgc
     9901 cgcagaaaac agaaatagtg cagaaggtag aactgtcttc cgaggaaatg gctttgtatg
     9961 agaatctccg tcagcaggct gttgctaata tcgaggaaag ttcgttgggg gctatgcagg
    10021 cattggcgga aatcactcgt ttacgtcagg cggcctgtca tccggctttg atcaatgata
    10081 agctgaaaat tgactcatcc aagacaaaag tatttatgga tttggtagat gaacttatcg
    10141 gcaatcagca ccgtgcgtta gtattcagcc agttcacgtc tcatctggct ttgattcgca
    10201 aagaacttga tttgcagggt atttcctatc tttatttgga tggaacgatg tctgtaaatg
    10261 agcgtgaaaa acaggtcagt cggtttcaac aaggagaggg acacctgttt ttgattagtc
    10321 tcaaagcggg aggtacaggg ctgaacctga cagccgccga ttatgtgatt catttggatc
    10381 catggtggaa tcctgctgtc gaagaccaag cttcagaccg tgtttaccgt atcggtcaaa
    10441 ctcgccctgt caccatctat cggctgatag cttccaatac gattgaagag aagattgtca
    10501 cgctgcatca aagtaagaaa tcattggcgg attctctact ggatggaagc aatatggcgc
    10561 ataaattgac taaagaagaa atgttggaac tgttgcgagg aggcattcaa taaaatggaa
    10621 tttgagagag aaaagcaatc gcttctgctt gaaggggtac gatatacagc caatgatttg
    10681 catttgttga aaacaaaggc ggtaggagca tccgattctt ctacagggca gatgttgtat
    10741 gacttcctgc aagagtggtt taccgaatct ccttggatga cagttcatac ttcgggatct
    10801 accggaaaac cgaaaaagat aaggattagc aaggataaaa tgatgcaaag cgcacgtctg
    10861 acctgcgaat ttctgaattt gcaaatagga gacactgctt tgttatgcat gaatctccgt
    10921 tatatcggag ctatgatggt agtcgtacgc tctttggttg caggtttgaa tctgattata
    10981 cgtcccgctt ccggtcatcc gttagcggat atgaaacagc ctttgagatt tgcggcaatg
    11041 gttcctctgc aagtttataa taccctgcag gtgcctgaag aaaaagaacg gttgcgacaa
    11101 acggatgttc tgataatcgg tggtggagca atcgatgagg ctttggaagc agaaatcaga
    11161 aatcttccgg gtgctatcta ttctacttat ggcatgaccg aaacgttgtc tcatattgct
    11221 ctccgccgtc tgaatggggt attagcttcc gaacgctatt acccttttgc ttctgtggaa
    11281 ctgtctttat cttctgaaaa tacattggtc attaaagccc ctttggtatg cgatgatatt
    11341 ttgcaaacca atgacattgc gcatatctat cccgatggaa gttttactat tctcggtcgg
    11401 aaagacaatg tcatcaatag cggcggaata aaaatccagg cagaggaaat agaaaaaatc
    11461 cttcgcccgt atattcccgt gccgtttgtc atcacttccg taccggatca acgtttgggg
    11521 caggcggtga ctttgttgct ggaagggcag ccggacatag aagaaataga agacaaacta
    11581 cagagtatat tagaacctta tcatcgtcct aaatacgttt tatatacaga ctgtataccg
    11641 caggcgggta atgggaagat gaatcgtgcg ggttgccgtg atttggcgga acggttatta
    11701 tcgtagtttg aaagtgaatg ttataccgtc gaccaccgca aattggtaaa gataggtgtg
    11761 gacttcgaca aagaaacccg taatatcggt cgctggttgg ttcaataaga gagccggggc
    11821 tcatctcata cttcttctaa acgcatcaaa caccattttc cagtttgttg agaacaacat
    11881 aactatgatg ctcatatcga aggttcatag gtttcacact tgtttgaatt gttataaatc
    11941 agacgactac ggtgatagaa atctgtgaat ctaggataaa taatccttca ccccttcacc
    12001 tcattataag ctatcaagat attgggtaag tttattcagg ttcatacaca ttcagatgtc
    12061 agataccttc atcttaagaa atccggaggt gacctacttt tatctgttaa tttgaagttt
    12121 aacgaactat tgtagatgct ccctcataat atactaatag ataaactcta ggctattaat
    12181 agaaaacttc cactctgtta cgcctaaact tcttttgtat ggcttgcaaa cttatattct
    12241 gcttattata aactataaac gaagctttca tttttataaa tgtaaccttt gtttttataa
    12301 ttgcaacttg cgtttataaa aacaaagctt gcatttatag tttgttgtta ggcaaatata
    12361 actttgtaac taatgcaaag aaagtttggt cttaatagga aggaagttat ctattaatag
    12421 tttggagttt acttactaat agacaatatg acaattgaca ataaaaaaat aaacttattg
    12481 ataaggtaat aatagaagga gtaatggcat atagtctttc aattcattcc tcaaaagttc
    12541 catcgtcttt tgtttgtatc ggttgataga tttcacgcta agattcattt cttctgcgat
    12601 ctctgcatgt gttttacctt caaagaaact tttcataaaa acagtgcgat agttttcggg
    12661 taacttattc agtgtctcgt acaacattct gtatagttca tcgagagtat acacactatc
    12721 tggctctgtc tcatagatag gcgctttctt ttgaatgttt tcggcataac tccattcata
    12781 ttcttggtgt ttcaggaaat tcagacaact gttttttaca cacatcttga tgtatcccaa
    12841 tgccgtgtcc gattgcaagt caaaggattc agtttcaaac ttatcccata atgaagtaaa
    12901 tacatctgaa acgatatctt cacgtgtttc tttatcatca acaaaccttt ttgcatacag
    12961 acaaaatggg gcgtaatatt cctcataaag ttgtttgaaa gtccgttctt tagtttgttt
    13021 ggaaaaagat attttcatta tttagagatt ctgtagtttt tcattttgct gcaaatatat
    13081 aataagataa ttatcagagc ctaattttcg attctttttt ttgctttcac ccctaatgaa
    13141 tggaaaataa tcagataaga ctgtcctttt gtatataggt tgattgtatt atatataaac
    13201 aggattaaaa tatgaaaaac aagttttttt tattggctat aaccttttgt ttgccaatac
    13261 atcctcaaga agtttccaag tcttttattc cgatggttga aatacctgcc ggaagttttt
    13321 atatgggaag tgacggatta ggcgaagatt ttgatgaggc tcctatccat caggtagtaa
    13381 tctctcgccc gtttcgtatg ggaatcactg aaataacgaa tgcgcaatat gagtcattcc
    13441 gtccggaaca tcgggcatta cgaggaaaaa acggtgtttc gctggaagat gatgaagcag
    13501 tcgtcaatgt gagttattcc gatgctgttg ccttttgtga atggcttagc cggaaagaag
    13561 gcaaaaacta tcgtttgcca acagaagcgg aatgggaata tgcttgtcgg gcaggcacat
    13621 acacactatt ttccacagga gacgggttac ctgcagttta tcatcggaat caaaaagtgg
    13681 ttcgtgactt tgatccggta tctttaaaag tagctcagac tcctcctaat acattcgggc
    13741 tttatgatat gcatggaaat gtggaagaat ggtgcttgga ttggtatgct tcttattccg
    13801 cagaaaagca gaaagacccg gcaggaccat tggcaggaga gtttcgggtc actagaggag
    13861 ggagtcatca caccccggag aaatacttgc gaagtgccaa tcgactggct atgctcccgg
    13921 aagataaaca ttcccaaacc ggatttagaa ttgtggaagc agatactcgt ttgaatgtat
    13981 cgggaacatc tgcccctgtc ccgttcaatc aggaatctgt aaaaaataca tctataaaat
    14041 ggaaaaaagt atctgctatc acaccgatgt ttctgcctcc gataccattt gtggtacgtc
    14101 cggcatgtga ttcgaatacc ccattttatc tgcataatca tcagcctgca gttacgtggt
    14161 gtgataatgg agatttgctg gcaatatggt tttctgcaaa tgaagagaat gggagaggga
    14221 tggtagtact cggttcccgc ttgcgtgccg ggcatactga ttgggatgtg gcttctttat
    14281 tctttaaagt tccggatcgg aatatgacag gaagcgcttt gctcaatgac ggaaaaggaa
    14341 aattgtatca tatcaatgga atggaagcat cgggtgactg gcagaatctc gcaatggtac
    14401 tacgtaccag cacagataac ggtgcttcat ggagcactcc taaactgata gctcccgaac
    14461 ataccaaacg tcatcaggta atagctggta cgattcgcac acgtgaggga tggctggttc
    14521 aagcctgtga tgcgggtccc ggcagtcatg acggggcagc tgttcaaatc agtaaagatg
    14581 gaggaaaaac atggtgcgat ccttgggatg gcgctccttt gccggatttc aaagaaggag
    14641 gaacgggaag tacaatcgca ggtatccatg cgggaattgt acaattaggg aacggaagtt
    14701 tgatggctat gggacgtggt aatagcatac ggaataaaga aggaaaactc cgaatgccaa
    14761 tgagcatatc agatgatatg ggaaagacct ggaaatatgt agcaagcgaa ctccctccta
    14821 ttgacggagg tcagcgtctt gttttaatga gactgaatga aggcccttta ttattggtgt
    14881 cttttacaga ccatccgcaa cgtacgcctt tggaagaacg tggtctggaa tttaaagata
    14941 aaaatggaaa tgtgaagaaa ggatatggca tgtatgcggc tctttcctac gatgagggaa
    15001 aaacatggcc ggtaagaaaa ctactgacgg acggtgaata tcgcttttta aacggtggag
    15061 catggacggg atatttcgaa atggatgaaa atcatgctga accacgtggc tatcttgcag
    15121 gaacacaaac tcctgataat gtggttcata tccttagtag ccgattgcat taccgcttca
    15181 atttggcatg gctcgaaaaa taaaataaaa aaagtttgtt tttgctgtcc ttttccaatt
    15241 acttcagttg tattataagt gtaattacaa ttaaaagata agattttgaa agaaaatatg
    15301 gaaaatatga gtccggaatc attgctccg
//
