LOCUS       gnlProkkaIBOLCLPD_159  13426 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IBOLCLPD_159.
ACCESSION   gnlProkkaIBOLCLPD_159
VERSION     gnlProkkaIBOLCLPD_159
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 16:28:21
            Original ID  :: gnl|Prokka|IBOLCLPD_159
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13426
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13426
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4658:7384]"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4659..7384
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
     cand_cluster    1..13426
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PF04055 and TIGR01716)"
                     /kind="single"
                     /product="RaS-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13426
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RaS-RiPP"
                     /region_number="1"
                     /rules="(PF04055 and TIGR01716)"
                     /tool="antismash"
     CDS             complement(76..795)
                     /locus_tag="ctg159_1"
                     /transl_table=11
                     /translation="MSEAIKLFQYNTLGALMAGLYGGTLTVGELLEHGDLGLGTLDSID
                     GELIVLDGKAYQAKGSEGKVEVVEVSPDEKVPYAAVVPHQAEVIFRQRFEMTDKELEDR
                     IESYYDGVNLFRSIKIKGHFKHMHVRMIPKSTPDTKFAEVATHQPEYESDNISGTIVGI
                     WTPEMFHGVSVAGYHLHFISDDLTFGGHVMDFVIENGIIEVGPVDQLDQRFPVQDRQYL
                     FAKFNVDEMRKDITKAE"
     CDS             complement(811..2487)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 503.4;
                     E-value: 1.4e-152)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg159_2"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.3e-52, bitscore:
                     168.1, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 7.3e-47, bitscore:
                     149.2, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEEKQLYGADLVVDSLINHDVEYVFGIPGAKIDRVFDTLEDKGP
                     ELIVARHEQNAAFMAQGVGRITGKPGVVLVTSGPGVSNLATGLVTATDEGDPVLAIGGQ
                     VKRADLLKRAHQSMNNVAMLEPITKYAAEVHDANTLSETVANAYRHAKSGKPGASFISI
                     PQDVTDAPVSVKAIKPMTDPKLGSASVSDINYLAQAIKNAVLPVFLLGNGASSEAVTYS
                     IRQILKHVKLPVVETFQGAGIVSRDLEEDTFFGRVGLFRNQPGDMLLKKSDLVIAIGYD
                     PIEYEARNWNAEISARIIVIDVEPAEVDTYFQPERELIGNVEASLNLLLPAIQGYKLPE
                     GSVEYLKGLKNNVVEDVKFDRQPDEGTVHPLDLIEVLQEQTDDDMTVTVDVGSHYIWMA
                     RYFKSYEPRHLLFSNGMQTLGVALPWAISAALVRPKTKVISVSGDGGFLFSAQELETAV
                     RLKLPIVHIIWNDGHYNMVEFQEEMKYGRSSGVDFGPVDFVKYAESFGAKGYRATSKAA
                     FASLLQEALTQAVDGPVLIDVPIDYKDNIKLGETILPDEFY"
     CDS             complement(2740..3912)
                     /gene_functions="transport (smcogs) SMCOG1020:major
                     facilitator transporter (Score: 61.4; E-value: 1.2e-18)"
                     /gene_kind="transport"
                     /locus_tag="ctg159_3"
                     /transl_table=11
                     /translation="MKIKKYAALSIYFNRFSSLISEYGYTILINILLSRISVQLVMYFW
                     VVKCLAAIVTNRINISNSKLSRKYLLILLEITKAILLFLLGFGLNHIIVLLVVFIIEVV
                     NVLFSSLLYSCVPIIIDKDSLIKFNARYTSIGSVSYFLAPLFVGLFINKSHFLLFAVYA
                     LLLIVGATSLLFLPNISTLNLKEERKKQNLNITLFNILRSKKIALVLLSGVIVGSIGVV
                     YDTYEVVYLTKYLGISDSMYSFSLSFLAVSFLVMSFLLSFVKQISSHMKAFALGLSFYV
                     LYLLLFSTSSNIYTVLMSYVFLAIGQTMMGIIETNYFQLSLNMKELQKLYIYSETLHSV
                     FSGIAVLVIGSFAFLSSHLVLVFRSLAVFALFILLCYCVFVNLKKLSIDK"
     CDS             complement(3919..4662)
                     /locus_tag="ctg159_4"
                     /transl_table=11
                     /translation="MKILSIIYDGGSRIPGARFAPTKYYQEAMLYDRKDSDIITINLGN
                     QDLFSIDLESLSRTIAESKVQIALGGDHSVTYLLAKATVREGAYLIVLDAHLDYFKDFE
                     SVVKNWNFLSFLTDIFEKIIIIGERNFEFPSSFDNKIIILSMEEYWLNKSRVLKKLDSY
                     IDESKDIYLSIDIDVLDPSVFDSVSYPIIGGFQMNDFLGIISKILCSDKVYFCDIVEYN
                     PMVGSDNAHIFYQMIQFVKSKLRRI"
     CDS             complement(4659..5876)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Streptide_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg159_5"
                     /sec_met_domain="Streptide_RRE (E-value: 5.2e-17, bitscore:
                     52.4, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2.3e-22, bitscore: 70.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 7.4e-11, bitscore: 32.7,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 2.4e-12, bitscore:
                     37.3, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 6.4e-10, bitscore: 29.7,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSNVYSIFFNWYNKQGILRNNRNNKLFSLNLATFLALKFMYQFS
                     LKKFSDSKSQVIKNVIDFLNNNEISLSKTNTKIVEFSTKIPLKVIQIEVTNKCNLRCMH
                     CYLPDYSKELDRKKISSIVYEAKQLGVMDVDFTGGEPLLLQGLSEIIEEVLKEGMCTTI
                     FTNAVYIPEDFKILIQRYDGIRLKVSLDGWNETIHDSIRGRGTFKRTIKNIEYFRSLGV
                     PVTVNVVLNNKNISGVKYFLELFDRLDVKYAFDRFLPFERNNRLSISDEEFNNAILCIP
                     NIQANCNNISESTFESFYCGAGNSYVFINSSGDVGFCPTLSSTKFCGGNINEKTLNDIW
                     INSKFFNHIRNVRCKYYNECPANYVCQGGCRSRAQFFGGSIGSPDIQECKLAYNLTGIK
                     PKSMSL"
     CDS             complement(5959..6108)
                     /locus_tag="ctg159_6"
                     /transl_table=11
                     /translation="MQVSDAIAQIELEEEEVVSSGLSIDIMEIKPSVATELIDGLKGRC
                     PPSV"
     CDS             complement(6168..6968)
                     /locus_tag="ctg159_7"
                     /transl_table=11
                     /translation="MRIIKFPEQISEDIIHYTFLDDIISYNCEKCRGSCCHVNNSLLLD
                     AKTASFLKRTYLKDFIVSDDSVSLLSCGKKCWFHSELGCTINDLGLNKPLTCELYPFHI
                     KKIQNFYIVSFTPCPTFQLNLGEGQRYKDIEDVVLRYIKTGVPVFSPSLHVSEERLKYE
                     IEYQNNFKNTLSEYYRTKTADGTTEFKEYEKWYIYYLDFRWGSIPLSYTSSQANQFWNL
                     YKRVCEDVYKKISYIRTDNIYFIIANQFNKIISKHFQLNFIDKE"
     CDS             complement(7028..7384)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: TIGR01716"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg159_8"
                     /sec_met_domain="TIGR01716 (E-value: 8.7e-21, bitscore:
                     64.6, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMLLSREMCKRSEFYKDLPNYRRLHSTMLLNCYIISIERDEYIDA
                     LYFEKQLNHSCFTETEIYEKLVFYYSKNLYELKKNRSNKAILEMKKCIAAMKLANSENL
                     AIKFENHLSGVLKM"
     CDS             complement(7520..7885)
                     /locus_tag="ctg159_9"
                     /transl_table=11
                     /translation="MKDYGKLFKKFRESRGLVLKDIAKLGVSVSHISRFERENTDLTIS
                     KFMSALNAINMPIDEFMYAANDFQRDEFNEILEKISLFVSARNVSGMEKLLISQVEKIE
                     KRETFYTLNTILIKIRL"
     CDS             complement(8219..8548)
                     /locus_tag="ctg159_10"
                     /transl_table=11
                     /translation="MKEIKLTPLDKVDRNGFLASYLAERSKKEPEILQHYNNEIECIKL
                     SHKIKQLRENINLTQQELADRMGKSQASIGRIENGTTNPTYKTLEEIAAATNTRLVVDF
                     VPIKN"
     CDS             complement(8663..8908)
                     /locus_tag="ctg159_11"
                     /transl_table=11
                     /translation="MALKLVRKVDRKKDIFELRINTEGIFARSLFFRLEKANEEEDNVA
                     SPTYIITNSFKKKTNKTPSKELKKAIKRKSNYKNKR"
     CDS             9179..9577
                     /locus_tag="ctg159_12"
                     /transl_table=11
                     /translation="MILKVNIGQSIRKEKVMKHKKMKQKRHKLAKERKNVSGEPGELIA
                     KRYFMYLKRFQAVGFLNPLQIRLIAETFAHIPTSYFFDENRNDWWNYYQMEVDYCEFLH
                     FKPKKKHLIAIRCLTIFYLCKFSIEIIL"
     CDS             complement(9530..9871)
                     /locus_tag="ctg159_13"
                     /transl_table=11
                     /translation="MDITNFIPSQRQAMLERFQQVDALGIGAVRIELKVANPVGIIYAC
                     YIIAGDNYFSDQAVVSFRILYEKDLDRISLDVVDIPGRSSLSNYLKLFEIFEGLQNYLN
                     REFAKVKNS"
     CDS             complement(10279..12111)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1190:GTP-binding protein LepA (Score: 550.5; E-value:
                     8.6e-167)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg159_14"
                     /transl_table=11
                     /translation="MPNIEELKQRQEKIRNFSIIAHIDHGKSTLADRILEKTETVSSRE
                     MQAQLLDSMDLERERGITIKLNAIELNYKAKDGETYIFHLIDTPGHVDFTYEVSRSLAA
                     CEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPAADPERVRTEIEDVIGL
                     DASEAVLASAKAGIGIEEILEQIVEKVPAPQGDVEAPLQALIFDSVYDAYRGVILQVRV
                     VNGMVKTGDKIQMMSNGKTFDVTEVGIFTPKAVGRDYLATGDVGYVAASIKTVADTRVG
                     DTVTLADNPAAEPLHGYKQMNPMVFAGLYPIESNKYNDLREALEKLQLNDASLQFEPET
                     SQALGFGFRCGFLGLLHMDVIQERLEREFNIDLIMTAPSVVYHVNTTDGEMLEVSNPSE
                     FPDPTRIDTIEEPYVKAQIMVPQEYVGAVMELAQRKRGDFETMEYIDDNRVNVIYQIPL
                     AEIVFDFFDKLKSSTRGYASFDYELSEYRRSQLVKMDILLNGDKVDALSFIVHREFAYE
                     RGKLIVDKLKKIIPRQQFEVPIQAAIGQKIVARTDIKALRKNVLAKCYGGDVSRKRKLL
                     EKQKAGKKRMKAIGSVEVPQEAFLSVLSMDEDEK"
     CDS             complement(12233..12397)
                     /locus_tag="ctg159_15"
                     /transl_table=11
                     /translation="MSDILHYIAEHPFFSLILLGIIVLAFGLAPFSSSSIENKRSAIIS
                     KHYNDNFKK"
     CDS             complement(12498..12761)
                     /locus_tag="ctg159_16"
                     /transl_table=11
                     /translation="MADSGITVNAYAPGIVKTPMMFDIAHEVGKNAGKDDEWGMQTFAK
                     DITLKRLSEPEDVAAAASFLAGPDSNYITGQTIIVDGGMQFH"
     CDS             complement(12921..13262)
                     /NRPS_PKS="Domain: PKS_KR (3-112). E-value: 1.5e-11. Score:
                     36.4. Matches aSDomain: nrpspksdomains_ctg159_17_PKS_KR.1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     116.1; E-value: 3.2e-35)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg159_17"
                     /transl_table=11
                     /translation="MSKVAIITGAGQGIGFAIAKRLVEDGFRVGLLDYNAETAEKAVAE
                     LSADKAFAVVADVSKQAEVAAAFQKVVDHFGDLNVVVNNAGVAPTKPLDTITEEQFQLT
                     FNINVGGVI"
     aSDomain        complement(12927..13253)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg159_17_PKS_KR.1"
                     /evalue="1.50E-11"
                     /label="ctg159_17_PKS_KR.1"
                     /locus_tag="ctg159_17"
                     /protein_end="112"
                     /protein_start="3"
                     /score="36.4"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VAIITGAGQGIGFAIAKRLVEDGFRVGLLDYNAETAEKAVAELSA
                     DKAFAVVADVSKQAEVAAAFQKVVDHFGDLNVVVNNAGVAPTKPLDTITEEQFQLTFNI
                     NVGGV"
     CDS_motif       complement(13185..13247)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg159_17_0001"
                     /evalue="1.90E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg159_17"
                     /protein_end="26"
                     /protein_start="5"
                     /score="14.1"
                     /tool="antismash"
                     /translation="IITGAGQGIGFAIAKRLVEDG"
ORIGIN
        1 tatccggtcc tctctagatg ttagcttttc gtcacccact acagttgaca aagagacagt
       61 atcttattta tatgcttatt cagccttagt aatatcttta cgcatttcat caacattgaa
      121 tttagcaaag agatattgac ggtcttgaac tgggaagcgt tgatcgagtt ggtcaactgg
      181 tccaacttca ataataccat tctcgataac aaaatccata acgtgaccac cgaatgtcaa
      241 gtcatctgaa ataaaatgga gatggtaacc agcaacactc acaccgtgga acatttcagg
      301 tgtccagata ccaacgattg tacctgaaat attatcagat tcatactctg gttgatgagt
      361 cgcaacttca gcaaatttcg tatcaggagt agacttaggt atcatgcgga catgcatgtg
      421 cttaaaatgc cctttaatct tgatggaacg gaagagatta accccatcat agtatgattc
      481 aatacgatcc tcaagttctt tatcagtcat ttcaaaacgt tgacggaaga taacttcagc
      541 ttggtgaggt acgactgctg catagggaac tttttcatct ggagaaactt ctaccacttc
      601 gactttacct tcagagcctt tagcttgata ggctttaccg tcaagaacaa tcaactcacc
      661 atcgatagaa tctaatgttc cgagacccaa gtctccatgc tctaacaact ctccaacggt
      721 taaagtacct ccataaagcc cagccatcaa ggctcccaaa gtattatatt gaaataattt
      781 tatggcttca gacatgtcta caccctcttt ttagtaaaat tcatctggca aaatagtttc
      841 gccgagttta atgttatctt tatagtcaat tggaacatca ataaggactg gtccatctac
      901 agcctgagtc aaagcctctt gaagcaagct agcaaacgct gctttacttg ttgcacgata
      961 acctttggct ccaaagctct cagcatattt tacaaaatct acaggaccaa agtcaacccc
     1021 agatgaacga ccgtacttca tttcttcctg gaattccacc atattgtaat gaccatcgtt
     1081 ccagataata tggacaattg gcaatttcaa acgaactgct gtttccaatt cttgtgctga
     1141 gaagaggaaa ccaccatcac cagaaacaga aatcactttt gtcttaggac gaaccaaagc
     1201 tgcagagata gcccatggaa gagcaacacc tagcgtttgc atcccatttg agaaaagcaa
     1261 atgacgtggt tcatacgatt tgaaataacg tgccatccaa atatagtgac taccaacatc
     1321 aaccgtaaca gtcatatcat catctgtttg ttcttgcaaa acttcgatta aatctagcgg
     1381 atgcaccgta ccttcatcag gctgacggtc aaacttaaca tcctcaacaa cattgttttt
     1441 caaaccttta agatattcaa ccgaaccttc aggcaattta taaccttgaa tagcgggcaa
     1501 aagcaagttt aagctcgctt ctacattacc aatcaattca cgttccggtt ggaagtaagt
     1561 gtccacctcg gccggctcaa catcaataac gatgatacgt gctgaaattt cagcattcca
     1621 gttacgtgct tcatattcga ttgggtcata accaatggca ataactaagt cggatttttt
     1681 aagcaacatg tctccgggtt ggttacggaa aagacctaca cgaccaaaga aagtatcttc
     1741 ttcaaggtca cgtgacacga taccggcacc ttggaaagtt tcaacaactg gcaatttaac
     1801 atgcttcaaa atttggcgaa tagagtaagt tacggcttct gatgaggcac cattccccaa
     1861 aagaaagact ggcaacactg catttttaat ggcttgtgct agatagttaa tatcagaaac
     1921 agatgctgaa ccaagttttg gatctgtcat aggcttaata gccttaacac tgaccggagc
     1981 atccgtcacg tcttgaggaa ttgaaatgaa gcttgcacct ggtttccctg acttagcgtg
     2041 acgataggca ttagcaaccg tttcagaaag ggtgttagca tcatgtactt cagcagcata
     2101 tttggtaatt ggctcaagca tagcaacgtt attcattgat tggtgggcac gtttcaagag
     2161 atctgcacgc ttaacctgac caccaatagc aagaacaggg tctccttcat ccgtcgctgt
     2221 taccaaacca gtagccaaat tggagacacc tggaccagat gttaccaata ctacacctgg
     2281 tttcccagta atacgtccaa caccttgagc cataaaagca gcattttgct catgacgggc
     2341 aacaatcaat tcaggtccct tatcttccaa ggtatcaaaa accctatcga tttttgcgcc
     2401 tggaatccca aagacatact caacatcatg gttgatcaaa ctatcaacca ctaaatctgc
     2461 accatacaat tgcttttctt ctgacatgaa cacagtcctt ctagccctaa aatggtagag
     2521 ccaactttcc tttcaagtat aagtcacaaa gtgtcaaagt ctgctcgttt tttcacaaac
     2581 tttcatcaat tcacaattct gttatcatta tagcacagtt ttcagacaat cttgtgaaaa
     2641 aaggcagact aggtgactaa aaaagacaaa cactcaaaat agcgtttgtc tactttataa
     2701 attaactatc tcatttgctt gttttctgat ttataaatat tacttatcaa tgcttagttt
     2761 tttgaggttt acaaacacac aataacacag aagaataaac agagcaaaaa cagcaagact
     2821 tctgaaaact aaaacaagat gactacttaa aaaggcaaaa cttcctatta ctaaaacagc
     2881 aatgcctgaa aatacagaat gtaaggtctc cgagtaaata tatagtttct gtaattcttt
     2941 catgttaagt gacaactgaa aataattggt ttcgattatc cccatcattg tctgacctat
     3001 cgctagaaaa acataactca ttagtactgt ataaatgttc gaagatgtac taaataaaag
     3061 tagatataga acataaaatg aaagacctaa ggcgaaagct ttcatatgag aacttatttg
     3121 tttcacgaag ctaagaagga agctcattac taagaatgaa actgctaaaa atgataagga
     3181 aaaggaatac atagaatcac taataccgag atactttgtt aaataaacaa cttcataagt
     3241 atcataaaca actccaattg atcccacaat aactccagat aatagaacta atgcaatttt
     3301 tttggatctc agaatgttaa ataatgtaat gtttaaattt tgtttttttc tttcttcttt
     3361 caaatttaaa gtcgaaatat ttggtaaaaa taaaagacta gtagctccca ctatcaaaag
     3421 aagagcataa actgcaaaca ataaaaagtg acttttatta ataaataaac caacaaacaa
     3481 cggtgctaaa aaataagata ctgaaccaat gcttgtatac ctagcgttaa acttaatcaa
     3541 tgaatccttg tctataataa ttggtacaca actatataat aaactggaaa acaatacatt
     3601 gacaacctca attatgaata caactaatag gacaattata tggtttaatc caaaacctag
     3661 taagaaaagt aagattgcct ttgtaatttc taacagaata agcaggtatt ttctgctcag
     3721 tttactattt gagatattaa tcctatttgt aactattgca gctaaacact ttaccaccca
     3781 aaaatacata actaattgca cagaaattct agacaataga atgttgatca agatagtata
     3841 accatactct gagattaacg atgagaaacg attaaaataa atactcaatg ctgcatattt
     3901 ttttattttc aatatttcct atatcctcct taattttgat ttaacaaatt gaatcatttg
     3961 gtaaaaaatg tgagcattat cacttccaac catcggattg tactcaacta tatcacaaaa
     4021 atatacctta tcagaacata aaattttgga aattattcca agaaaatcgt tcatttgaaa
     4081 tcctccaata ataggatatg atactgaatc aaaaacagat ggatccaaaa catcaatgtc
     4141 tattgataag taaatatctt ttgactcatc aatataacta tctaactttt tcaaaactct
     4201 actcttattt aaccaatact cctccattga gaggatgatt attttattat caaatgaact
     4261 aggaaactca aaattccttt ccccaatgat aattattttt tcaaaaatat cggttaaaaa
     4321 acttaaaaaa ttccaatttt ttacaacact ttcaaagtct ttgaagtaat ctaaatgagc
     4381 atctaaaaca attaaatatg ctccctctcg aacagtggcc tttgctaata gataagtaac
     4441 tgaatgatct cctcctaaag caatctgaac tttagattca gcaatagttc gacttagact
     4501 ttctaaatca atagaaaata aatcttgatt acctaaatta attgtaatta tatcagaatc
     4561 tttcctatca tataacatcg cttcttgata atattttgtg ggagcaaatc tcgctcctgg
     4621 aattctactt ccaccatcat aaataataga taatattttc ataaactcat tgactttggc
     4681 ttaatcccag ttaaattata tgctaacttg cactcctgta tatcgggact cccaatagaa
     4741 cctccgaaaa actgagctcg acttctacac ccaccttgac aaacataatt tgcagggcat
     4801 tcattataat acttacatcg tacatttcga atatgattga agaacttcga attaatccaa
     4861 atatcattta aagtcttttc attaatgtta cctccacaaa atttagtgga ggataatgtc
     4921 ggacaaaatc caacatcacc tgacgaattt ataaacacat aagaattgcc agcaccacaa
     4981 taaaatgatt caaatgtgga ttcggatata ttattacaat ttgcttgaat attgggaata
     5041 cacaaaatag cattattgaa ttcttcatca ctaattgata gtcgattatt cctttcaaaa
     5101 ggtaaaaacc tatcaaaagc atatttcaca tctaatcgat caaacaactc caaaaaatac
     5161 ttcactccac taatattctt gttattcaaa acaacattaa cagtaacagg tactcctaaa
     5221 ctcctaaaat attcaatatt cttaattgtt ctcttaaatg tacctcttcc tctaattgaa
     5281 tcatgtattg tttcattcca accatctaaa ctaactttta gtcttatacc atcatatctt
     5341 tgaatcaata ttttaaaatc ttcaggaata tatacagcat ttgtaaaaat tgttgtacac
     5401 attccctctt ttaatacttc ctcgataatt tcacttaatc cctgtaataa taatggttcg
     5461 cctccagtga aatcaacatc cattactcct agctgcttag cttcatatac tatacttgaa
     5521 attttctttc tatcgagctc ctttgaataa tcaggtaaat aacaatgcat acatcttagg
     5581 ttacatttgt tcgtgacctc aatctgtatc acttttaatg gtattttcgt tgaaaattca
     5641 acaattttag tgttggtctt agagagtgat atttcattgt tatttagaaa atctataaca
     5701 ttttttatta cctgactctt tgaatcagaa aactttttca atgaaaattg gtacataaat
     5761 tttaaagcta aaaatgtagc taaatttaat gaaaatagtt tattattcct attattcctg
     5821 agtattcctt gcttattgta ccaattaaaa aaaatcgagt aaacattgct cgtcatatta
     5881 attccctgca atcttccaaa aatattaata taaaaaccaa aggattagaa atagactcta
     5941 atcctacaat cagttctatt agacagacgg tgggcaacga cctttgagtc catcaatcaa
     6001 ctctgtagca acagaaggtt taatttccat aatgtcaata gatagaccgc tagaaacaac
     6061 ttcttcttct tctaattcaa tttgtgcaat agcatcacta acttgcatcg taatatcctc
     6121 cattatttat ttaagaatca ataagtaccc ataacaaatc atagaaatca ttctttatct
     6181 ataaaattta gctgaaaatg ctttgaaatt atcttattaa actgatttgc aataataaag
     6241 tatatgttat ctgttcgtat atatgatatt tttttataaa catcttcaca aactctcttg
     6301 taaagattcc aaaattgatt tgcttgtgaa cttgtataag ataagggtat acttccccat
     6361 ctaaaatcta aataatatat ataccatttt tcatattctt taaactctgt agtgccatcg
     6421 gcagtctttg ttcgataata ctctgataaa gtgtttttaa aattgttttg atactcaatc
     6481 tcatatttca gcctttcctc tgaaacatgc aaagacggac taaaaactgg caccccagtt
     6541 ttaatatatc gtaaaactac atcctctata tccttgtacc tctgcccctc accaaggttc
     6601 agttgaaatg tcggacaagg agtaaaagaa acaatataga agttctgaat tttcttaata
     6661 tgaaaaggat ataattcaca agttaatggc ttgttcaagc ctaaatcatt tatcgtacaa
     6721 cccaattcag aatgaaacca gcacttttta ccacaactca acaatgaaac actatcatca
     6781 ctaacaataa aatctttaag atacgtgcgt tttagaaaac ttgctgtctt tgcatcaagt
     6841 aataaagaat tattcacatg acaacaagat cctctacact tttcacaatt ataagagata
     6901 atatcatcta gaaacgtata atgaatgata tcttctgaaa tctgttcagg aaatttaata
     6961 attctcatat caataatata tcatttaatt ttgacactga taatttatac catatacaca
     7021 aatccaacta catttttaac actccagata aatgattttc aaattttata gctaaattct
     7081 cactattagc cagcttcatt gcagcaatac acttcttcat ttctagaata gctttattgc
     7141 tcctattctt ctttaattca tataaatttt ttgaataata aaacactaat ttctcgtaaa
     7201 tctcagtttc cgtaaaacaa ctatgattta actgtttttc aaaatacaac gcatcaatat
     7261 actcatctct ttcaatactt atgatataac aatttaatag cattgttgag tgtaaccttc
     7321 ggtagtttgg taaatccttg taaaattctg aacgtttaca catttctctt gataaaagca
     7381 tcattgtttg atgattcaat acatctacag tattcgcaaa taacagtagt tcgtaacaac
     7441 cccaatattc tacagagaat aggtagtctg ataaatattg gatatcagat tcatcatagt
     7501 aacttttgtc tgataagtcc tataaacgaa tttttattaa aatagtattt agagtataaa
     7561 aagtctcacg cttttcgatt ttttctactt gagagattaa taacttttcc atacctgaca
     7621 cgttccttgc tgaaacaaat aaactaatct tttctaagat ttcattaaac tcatctctct
     7681 gaaagtcgtt tgctgcatac ataaactcat caataggcat atttatcgca tttaaagctg
     7741 acataaactt actaattgtc aaatctgtat tttcacgttc aaagcgggaa atatgagata
     7801 ctgatacgcc taactttgcg atatctttta agactaatcc cctagactct ctaaatttct
     7861 taaataattt tccataatct ttcataaaaa gcacctcttt tgcatatacg agaatttccc
     7921 agataaactt aaaagtatta tatcatatag tgagatagga ggttaatttc tatgaataaa
     7981 gaaagttttt tagctatctt acttctaatt tttgaaagca ttattgtaat tgctgttggc
     8041 taaacaaata gaaaataaag acaccacaaa agttagactt tcgatgtcta acttttgtgg
     8101 tgtagttaag gtatgatgtt gttctctaat aagggtataa tataaaaaag actctatgat
     8161 ttctgtaata ggtaaaacca ctatagagat tatagagctt tttgagtgta tacaaaaact
     8221 agttctttat tggaacaaag tcaacaacta atctagtatt ggttgcagcg gcaatttctt
     8281 ccaatgtttt atatgttgga ttagtggtgc cattctctat acgtccgata ctagcctgac
     8341 tttttcccat acgatcagca agttcttgct gagttaaatt gatattctct cttaattgtt
     8401 taattttatg cgatagcttt atacactcga tttcattgtt atagtgctgt agaatttcag
     8461 gttccttttt actcctttct gccaagtatg aagcaagaaa cccgtttcta tccactttat
     8521 caagtggtgt aagtttgatt tccttcatgt gcatctctcc ttaataaaat atagtcaata
     8581 tccatactaa actttacagt ccagttttaa aggttgaatc tttttcagcc cttaaaactg
     8641 gattgcgaga atccagtttg tgtcatcgct tgttcttata gttcgatttt cgtttgatag
     8701 ctttcttcaa ttccttagat ggtgttttat ttgttttttt cttaaaggag tttgtgatga
     8761 tataagtagg tgaagccaca ttgtcttctt cttcgttagc tttttctaaa cggaaaaata
     8821 atgaacgggc gaaaatgcct tccgtattaa ttctaagctc aaagatatct ttttttctat
     8881 ctacttttct gactaacttt agagccatgg cttctgctat accgatagca gaaacctctc
     8941 gtatccttgc gataaccttt gacgctacag ttaaggggag ggaatctaaa aacgctgcaa
     9001 attcgtcttc gtcataataa ataaaggtta gtttagaggg ggctttatta cttgctgttt
     9061 atggatttga gagatcctta gtattgtcca ttggacacca ttacctttcc gacgagcgga
     9121 aggcctttct ttcatttatt tcccttttga gggattattt gatataatta tagcatatat
     9181 gatattaaaa gtcaatatag gtcagtcaat taggaaggaa aaagttatga aacataaaaa
     9241 aatgaagcaa aaaaggcata aactagccaa agaacgtaag aatgtatcag gtgagccagg
     9301 agaactaatc gctaaacgat attttatgta tttaaagcgg ttccaagcag ttggtttttt
     9361 gaaccctttg caaattcggt taattgctga gacgtttgca catattccta ctagttactt
     9421 cttcgacgaa aatcgtaacg attggtggaa ttattatcaa atggaggttg actattgtga
     9481 atttttgcac ttcaaaccta aaaagaaaca cctgattgct atcagatgtt taactatttt
     9541 ttacctttgc aaattctcga ttgagataat tttgtaagcc ttcaaaaatt tcaaataact
     9601 ttaggtaatt tgacaaactt gatcgcccag ggatgtccac tacgtccaaa gaaatcctat
     9661 ccaagtcctt ttcgtataga atacggaaag acaccacagc ttgatcagaa aaataattat
     9721 cgccagctat aatgtagcac gcataaataa taccaacagg attagcaacc ttcaactcaa
     9781 tacgaactgc acctattcct aaggcatcca cttgctgaaa acgttccaac atagcctgtc
     9841 gctgactagg aataaaattt gtgatatcca tagtggccct cccaactttc cttttgtata
     9901 ttatagccta aagctgagaa aaatgcttgc gaagggattc ctgataagac tacctcccat
     9961 gaatccttat ctagcttctt tatattctct aaagtctgat tttatagtgt ttatcgtaat
    10021 gtagtaagtg tgttctacat gactaagtac aacatattgt tgacgactac caaaaatctc
    10081 attggaagtt accttatctg cttttaggtc agtctataat tctgctacat gctttgtatc
    10141 gtcatttccc taaaaagaaa agtatttagt ataatcgtag cataaatcct tccacacttt
    10201 gagaaggtaa attttaaaat cttctttatc ataacttttt acaaaaatag ccagaacatc
    10261 acattctgac tatcattctt atttctcatc ttcgtccatt gaaagcacag acaagaaggc
    10321 ttcttgtggt acctccaccg aaccaatggc tttcatacgt ttcttaccag ctttttgttt
    10381 ttcgaggagt ttacgtttac gtgaaacgtc accaccgtaa catttagcca agacgttttt
    10441 acgaagagct ttgatatctg tacgggcaac aattttttga ccaatagccg cttggatagg
    10501 aacttcaaat tgttgacgtg gaataatttt cttaagttta tcaacgataa gttttccacg
    10561 ttcgtaggca aattctctat ggacaataaa gctaagggca tcgaccttat caccattaag
    10621 gagaatatcc attttcacca attgtgaacg acggtactct gacaattcat agtcaaaact
    10681 tgcataacca cgagttgatg acttcaattt atcaaagaag tcaaagacga tttcagcaag
    10741 tggaatttga tagataacgt taacacgatt atcatcaata tattccatgg tttcaaaatc
    10801 accacgttta cgttgcgcca actccataac agcaccaaca tactcttgag gaaccataat
    10861 ttgagctttg acataaggct cttcaatggt atcaatacgt gtaggatctg gaaattcaga
    10921 tgggttggac acttcaagca tttcaccgtc agtagtgtta acatggtaaa ctactgatgg
    10981 tgcagtcatg atgagatcga tgttaaactc acgttccaaa cgctcttgga taacatccat
    11041 gtgaagaagg cccaagaaac cacaacggaa accaaaacca agggcttgag acgtttcagg
    11101 ctcaaattga agactggcat cattcaattg gagcttttca agagcctcac gcaagtcgtt
    11161 atatttattt gactcaattg gataaagacc agcaaagacc attgggttca tttgcttata
    11221 accatgaagt ggttctgcgg ctggattatc cgcaagtgtc actgtatcac cgacacgagt
    11281 atccgcaact gtcttaattg aagctgctac ataaccaaca tctccagtcg caaggtagtc
    11341 acggccaaca gctttaggag tgaaaatacc aacctcagta acgtcaaagg tcttgccatt
    11401 agacatcatt tgaatcttat cgcccgtttt aaccattccg ttaaccacac gcacttggag
    11461 tatgacgcca cgatacgcat cataaacaga gtcaaagata agggcttgga gaggtgcttc
    11521 cacatcacct tggggcgcag gaactttctc aacaatttgt tcgagaatct cttcgatacc
    11581 aatgccagcc ttagctgatg caagcacagc ttccgaggca tctaatccga taacatcttc
    11641 aatctctgta cgtacacgct caggatctgc cgctggaagg tcgattttat tgataactgg
    11701 taagatttcc aagtcattat caagtgccaa gtaaacattg gcaagtgttt gtgcttcaat
    11761 cccttgagct gcatctacca ccaagatagc accctcacag gcggcaaggg aacgtgacac
    11821 ctcataagta aagtccacat gtcccggtgt gtcgataagg tggaaaatat aagtctcgcc
    11881 gtctttagct ttgtagttaa gctcaatggc attcagtttg atagtgatac cacgttcgcg
    11941 ctcaagatcc atactatcaa ggagttgtgc ctgcatctca cgacttgata cagtttcagt
    12001 cttttccaag atacggtcag caagcgttga tttaccatgg tcaatatgag caataatcga
    12061 gaagttgcga atcttctcct gtctttgttt taattcttca atatttggca ttttattctt
    12121 tcctagttct tacttgtgat tgttaaaaaa cgaaccgtca cctcctatta tacaaaaaag
    12181 acagacattt gcctatctct aatatctgct ttatgactgc atttagtcct tcttatttct
    12241 taaaattatc attgtagtgc ttactaataa tagctgaacg cttgttctct attgaactac
    12301 ttgaaaatgg agctaaacca aaggctagta caataattcc caatagaata agactaaaaa
    12361 acgggtgctc agcaatatag tgtaagatgt ctgacatggg aatccacctt taaaaacata
    12421 attatttata actatattat cagaaacatt atgttttatc aagcaaaaaa gagagccatt
    12481 cgctctccct tttaacctta atggaattgc ataccaccat caacgatgat tgtttgacct
    12541 gtaatgtagt ttgagtcagg tccagctagg aagctagctg ctgctgcaac atcttcaggt
    12601 tctgacaaac gtttgagggt aatatcttta gcaaaagttt gcatacccca ctcatcatct
    12661 ttaccagcat ttttaccaac ttcgtgggca atgtcaaaca tcattggagt cttaacgata
    12721 cctggtgcat aagcatttac agttatacct gaatcagcca agtcacgcgc caaagtttga
    12781 gtaataccac gaactacgaa tttagttcta ccatatacag ttaagttaga gttccctacg
    12841 acacctgctt gtgaagttgc attgataatt ttaccaccat gaccaagtga tttaaattgt
    12901 gcttgggcag cttgtgcacc tcagataact ccaccaacat taatgttaaa tgtaagttga
    12961 aactgttctt cagtaatagt gtcaaggggt tttgttggtg ccacaccagc attattaaca
    13021 acaacattca agtcgccaaa gtgatcaact actttttgga aagcagctgc tacttcagct
    13081 tgtttagata catcagctac aactgcaaat gctttatctg ctgacaattc agcaacagct
    13141 ttttctgcag tttcagcgtt gtagtccaat aatccgactc taaaaccatc ttcaaccaaa
    13201 cgttttgcaa tcgcaaaacc aataccttga cctgcacctg taataatagc aacttttgac
    13261 atacgaaatc cccctctacc aattggagtc acaagcttag taagaagcct tatctcaatt
    13321 ggaatacgct aagttagtca agttctggca aagtcatttt cataggcttt gtcttaactc
    13381 atttagaatc ttaccacttt atgaaagcgt tgttaataat ttgtca
//
