LOCUS       gnlProkkaIBOLCLPD_169  10791 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IBOLCLPD_169.
ACCESSION   gnlProkkaIBOLCLPD_169
VERSION     gnlProkkaIBOLCLPD_169
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 16:28:21
            Original ID  :: gnl|Prokka|IBOLCLPD_169
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10791
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10791
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[7470:7653]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      7471..7653
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..10791
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10791
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             3..1175
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 268.2; E-value:
                     2.5e-81)"
                     /gene_kind="transport"
                     /locus_tag="ctg169_1"
                     /transl_table=11
                     /translation="MKINQYARENLTGLRVIRAFAREDFQEKKFASENAVYADNSSKLF
                     KLTGLTEPLFVQIIIAMIVAIVWFALEPLGSGTLAIGDLVAFIEYSFHALLSFLFLANL
                     FTMYPRTAVSSERLQEIMDMPISINPNEDGVTETETRGYLEFDNVTFAYPGETESPVLH
                     NISFKARPGETIAFIGSTGSGKSSLVQLIPRFYDVTLGRILVDGVDVRDYNLKALRRKI
                     GFIPQKALLFTGTIGENIRYGKENASHEELNQATDVAQAKEFIESKEERYDSHLAEGGS
                     NLSGGQKQRLSIARAVVKRPDLYIFDDSFSALDYKTDATLRRRLKEVTQDATVLIVAQR
                     VGTIMDADQIIVLDKGEIVGRGRHEELMESNEIYREIANSQFNQKSLTED"
     CDS             1188..2975
                     /gene_functions="resistance (resist) ABC_efflux (Score:
                     283.6; E-value: 1.9e-86)"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 326.3; E-value: 6e-99)"
                     /gene_kind="transport"
                     /locus_tag="ctg169_2"
                     /transl_table=11
                     /translation="MKDNKKKTTHSSSFGRLWSYLQVYRFPLYLAIFLKIISVIMSVIE
                     PVVIGLAITELTKNTLDIIKGVAGAHINVSYVGLVLVFYLLRGLIYELASYYSNYFMTN
                     AVQATVQDMRNEMIEKINRTSVSYFDKQQFGDLLGRFTSDVETVSNALQQSFLQVVNAI
                     FTLALVIGTVLYLNLQLGAVFVITIPISYFGARFIMSKSQPYFKQQADALGTLNGFVQE
                     NLTGFNVIKLFGREGRSLDDFKEITEDLQKVGFKANFISGLMMPFLNGLSDLTYLIVAV
                     LGGLQVLAGRLTIGNMQAFVQYVWQINQPIQNLTQLAGQLQSAKSSLDRIFQLMNEPDE
                     ANDATEVLEGDLTGQVIFNHVDFQYVADKPLIRDFNLEVNPGEMVAIVGPTGAGKSTII
                     NLLMRFYDVTAGSISVDGHDIRNLSRKDYRKQFGMVLQDAWLFEGTIKENLRFGNLEAT
                     DEEIVEAAKAANVDHFIRTLPGGYNMEINQESSNISLGQKQLLTIARALLADPKILILD
                     EATSSVDTRLELLIQKAMKTLMQGRTSFVIAHRLSTIQEADKILVLKDGQIIEQGNHES
                     LLADKGFYYDLYNSQFAEK"
     CDS             complement(3073..4116)
                     /locus_tag="ctg169_3"
                     /transl_table=11
                     /translation="MNTNDFDFELPEELIAQTPLEQRDASKLLVIDPVTREMTDTHFDH
                     IIDQLNPGDALVMNNTRVLPARLYGEKTDTHGHVEFLLLKNTQGDQWEVLAKPAKRLKV
                     GAKVSFGDGRLTATVTKELDHGGRIVEFSYDGIFLEVLESLGEMPLPPYIHEKLEDRDR
                     YQTVYAKENGSAAAPTAGLHFTPELLQKIEAKGVKLVYLTLHVGLGTFRPVSVDNVDEH
                     EMHSEFYTLSQEAADTLNSVKAAGGRIVAVGTTSIRTLETIGNKYDGQLQADSGWTNIF
                     IKPGYQFTVVDAFSTNFHLPKSTLVMLVSAFAGREFVLEAYKHAVQERYRFFSFGDAMF
                     VTRPSEK"
     CDS             4266..4967
                     /locus_tag="ctg169_4"
                     /transl_table=11
                     /translation="MKKILVKNQVEGGKVAFELLKESLTAGAQTLGLATGSSPIALYQE
                     MVESDVDFSELYSVNLDEYVGLSPEHEQSYHAFMKAQLFDAKPFKESFLPDGMAEDLEK
                     AAKDYDDVLAQHVIDLQILGIGSNGHIGFNEPGTPFDSQTHVVDLTDSTIEANSRFFAS
                     RDQVPTKAISMGIASIMAAKKIILFAYGDKKADAIFKMVKGPVTEEVPASVLQHHPDVT
                     LILDEAAAAKL"
     CDS             complement(5133..6428)
                     /locus_tag="ctg169_5"
                     /transl_table=11
                     /translation="MLVGLRIISILYDLFLASMLFYRPLSKINMKKKPLVALFFILIFH
                     GELVFLFSESRIFLVSNLLLNILEYYLIGLNFDYPIRQSSFWILLQTSLSLLAGAVLNQ
                     GIQLILPLGELSKNLEAISLYLGISFFLSTGITLILRKLLLSHQRLRIATSKGNWLYQF
                     IVPLLSIFFAFTISAIQGGVFGADYLSIISLSSLIVLTLSSLYFNLYLARQQQQYYQNQ
                     LEKEQLQFQVREIQQSQEEYQRLQSLRHDLKNKHLTLLSLLEKNPEEAKDYLYSLTDSI
                     VGEQTFYSKNQTINFLLNQKLHHLKDEIEMEIDCFVPQELSIQPDILAVILGNCLDNSI
                     TACLRLPNKERNLSLNIRYFQQNLFINIRNNFDEKEKSTRKSRQKDGWGLRNIDALVQE
                     YQGNIKHFIKDGQYQIEILLPIKIGTIPTKEF"
     CDS             complement(6428..7138)
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 58.5; E-value: 1.2e-17)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg169_6"
                     /transl_table=11
                     /translation="MLKVAICDDSDRDASQLEHYLLSYDKFPLETKLYTNPQKLLNQLT
                     PDIHCVFLDINMPGINGIDVAQKIRKFNPFIPIIFVTSYRDYMEQVFEVQTFDYIVKPI
                     EPQKLMKVLDRILRFLDIGQALFTFSFGKHNYSVPSSDIVFFEKDKRSVFIYTKTGTYK
                     SLLKTKEILEKLPNYFIQIHASYILNPKYIKDFDSKTVTILLNGTEEHLLPISRKFQFS
                     FKEKYYSYLSERHF"
     CDS             7471..7653
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Pantocin_Microcin_RRE"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg169_7"
                     /sec_met_domain="Pantocin_Microcin_RRE (E-value: 8.2e-10,
                     bitscore: 28.4, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFHCPRIKEIYPIYKLHDNLFRVGSQIGITTEISDEDDKMWSLV
                     NILDGRTINDVVDII"
     CDS             7668..8603
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ThiF"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg169_8"
                     /sec_met_domain="ThiF (E-value: 7.4e-50, bitscore: 159.1,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEQDIIGAIELLDKEGVIEEGATINCIKERYHSNIYYFSRYLNS
                     FKDSIDIQKRLNETTVLLLGLGGGGSNILTLLSGLGPKKIKIVDFDIIEKSNLGRQFLY
                     KEEDVGALKTQIAHQEVSKMNSDIEVETHNLRITCVNDLLPLLDNVDIVICVIDEPQYD
                     IQRIVNKAVVTKNIPCVFGASQVSRGRVYSVVPHQTGCFDCLNIHYTKIDSLFLEQFRG
                     IRTVTKKIPTIAYGPAMFQLTSAIVDEAVRLITKYAEPMSLNRQYEINYENGASFTHKP
                     WGHYPDECPTCGNGKEENWEIFSQYGEIKL"
     CDS             8600..9511
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 171; E-value:
                     5.6e-52)"
                     /gene_kind="transport"
                     /locus_tag="ctg169_9"
                     /transl_table=11
                     /translation="MTFETLTIENLTKSFDKQHFANNHIFLELEAAKITALIGHNGAGK
                     STLLKQMIGFIKPDQGDVHYGDISFIHNRKQARTMMSYMSQQYAPLEKLTVEQNLEMIG
                     RMRGLSTSELQKEIEHLLADLEIVEYRDKKGKNLSGGLKRLTSFAMALIGSADIMLLDE
                     PTNDVDPVRREKQWRLLQKLAYKGHTIIIVTHNLLEVEKYADNFALFNHGKLLKSGPVH
                     QMSYKNHYQISFNFVSKEFLSLFEHFTMVNGCVCQMEIEESELTRILIQVKEGIEKGLI
                     SNLSVKMKTLSISDLYKEELVN"
     CDS             9513..10235
                     /locus_tag="ctg169_10"
                     /transl_table=11
                     /translation="MTQFFYLLRWNYLRQKNLFILFTLAQVLLSVSLLFGYPLVIGKMD
                     TTTAYYLASGSVLMGVISIGCTISSPVIANAKSEGHVDYIRALPIPRILISLADLCIWL
                     IAILPGVFFTFLLGCLRFSVQLNLSILSVFVMLLICLTMISLGFSIAYIFSQNIVTLMS
                     QLILMIGLMFSPIMYPAGRLPDWLDQLYFLLPFVPSANLLRASFYRHGTVSLVDIGVLI
                     FWIFLTQLLILGTLQKEL"
     CDS             10425..10790
                     /locus_tag="ctg169_11"
                     /transl_table=11
                     /translation="MAKPIRVLLYYKYVPIENAEQFAADHLAFCKSIGLKGRILVADEG
                     INGTVSGDYETTQKYMDYVHSLPGMEDLWFKIDEEEEQAFKKMFVRYKKEIVHLGLEDD
                     NFDSDINPLETTGAYLSP"
ORIGIN
        1 tcgacaagat taaccagtat gctcgtgaaa atctgactgg acttcgtgtc atccgagctt
       61 tcgctagaga agattttcaa gagaagaagt tcgcttctga aaatgctgtc tatgcggata
      121 attcaagcaa acttttcaaa ttgactggtt tgaccgagcc actttttgta caaatcatta
      181 tcgctatgat tgtggctatt gtttggtttg ctcttgagcc attaggttct gggactttag
      241 caatcggtga cttggttgcc tttattgagt acagcttcca tgcactattg tccttccttt
      301 tcctagccaa tctctttacc atgtatcctc gtacggcggt gtctagtgaa cgtctgcagg
      361 aaattatgga catgccgatt tctatcaatc caaatgaaga tggcgtgaca gaaaccgaga
      421 ctaggggata tttggaattt gacaatgtga cctttgccta tcccggtgaa actgaaagtc
      481 ctgtcctaca caacatttct ttcaaggcta gaccaggtga aaccattgcc tttatcggat
      541 ctacgggttc aggaaaatca tcacttgtac agttgattcc acgcttttat gatgtaacac
      601 ttggacgcat tcttgttgat ggtgtagatg tccgtgacta caatcttaag gctcttcgtc
      661 gtaagattgg ctttatccca caaaaagccc tactctttac agggactatc ggtgaaaata
      721 tccgttatgg taaggaaaat gccagtcatg aagaattgaa tcaagccact gatgtggctc
      781 aagccaagga atttatcgaa agtaaggaag aacgctatga ttctcacttg gctgagggtg
      841 gtagcaacct ttctggtgga cagaagcagc gtttgtcaat tgcacgtgct gtggttaaac
      901 gtcctgacct ttacatcttt gatgattcct tctctgcctt ggactacaag actgatgcga
      961 ccttgcgccg tcgtctaaaa gaagtgaccc aggatgcgac agtcttgatt gtggctcaac
     1021 gtgtgggaac cattatggat gcagatcaga ttatcgttct tgataagggt gaaattgttg
     1081 gtcgtggccg tcacgaagag ctcatggaaa gtaatgagat ttaccgtgag attgctaatt
     1141 cacaatttaa tcaaaagagt cttacggaag actagaagga ggtgaaaatg aaggataata
     1201 aaaagaaaac aactcattcc tcaagttttg gccgcctttg gtcatacttg caggtttatc
     1261 gtttcccact ttacttagct attttcctga aaattattag tgtcatcatg agtgttattg
     1321 agccggtggt cattggttta gccattacgg aactgactaa aaatacactg gacatcatta
     1381 agggggtagc aggtgctcat atcaacgtgt cctacgttgg tttagttttg gtcttttacc
     1441 tcttgcgtgg tctcatctat gagttggctt cttactattc caactatttt atgaccaatg
     1501 ccgtgcaagc aacggttcag gatatgcgaa atgagatgat tgagaaaatc aatcgtacct
     1561 cagtgtcata ctttgataag caacaatttg gagacctttt gggtcgcttt actagtgacg
     1621 tcgagacagt ttcaaatgcc ttgcagcagt cattcttgca ggttgtcaac gccatcttta
     1681 ctctagcctt ggttattggg acagtgcttt accttaatct tcagttggga gctgtgtttg
     1741 ttatcactat tccgatttct tactttggtg ctcgcttcat tatgagtaag tctcaacctt
     1801 actttaagca gcaggctgat gccctaggta ctcttaacgg ttttgttcag gaaaatctga
     1861 ctggtttcaa tgtgattaaa ctttttgggc gtgagggtag atcattagac gactttaaag
     1921 aaattacgga agaccttcaa aaggtaggtt ttaaggccaa tttcatttca ggcctcatga
     1981 tgcctttcct taatggttta tctgacttga cctatctaat tgttgccgtc ctaggtggtt
     2041 tgcaagtctt ggctggtcgc ttgacgattg gtaatatgca ggctttcgtt cagtacgttt
     2101 ggcagattaa tcaacctatt cagaacttga ctcagctggc tggacaattg cagagtgcta
     2161 aatcttcctt ggaccgtatt ttccaactga tgaatgaacc agacgaggct aatgatgcta
     2221 ctgaggtgct tgaaggagat ttaactggtc aagttatctt taatcatgtg gacttccagt
     2281 atgtagctga taaacctttg attcgtgact ttaatcttga ggttaatcct ggtgaaatgg
     2341 tggctattgt cggtcctacc ggtgctggaa aatcaactat tatcaatctt ctcatgcgtt
     2401 tctatgatgt tactgcaggt tctatctcgg ttgatggtca tgatatacgc aacttgtcgc
     2461 gtaaagatta tcgtaaacag tttggtatgg tgcttcagga tgcttggctc tttgaaggaa
     2521 ctatcaagga aaatcttcgt tttggtaatc ttgaggcaac tgatgaagaa attgttgaag
     2581 cagcgaaggc tgccaatgtg gatcacttta tccgtacgct gcctggtggc tacaacatgg
     2641 aaataaacca ggaatcaagt aacatttcac tgggacaaaa gcaacttttg accatagccc
     2701 gtgcactttt ggctgaccct aaaatcttga ttttggacga ggcaacctca tcagttgata
     2761 cccgtctgga actcttgatt caaaaagcca tgaagacact tatgcaaggt cgaacaagtt
     2821 ttgtcatcgc tcaccgttta tcaacaatcc aagaagcaga caagattttg gtccttaaag
     2881 atggacaaat catcgaacaa gggaaccatg aatccctcct tgcagataaa ggtttctatt
     2941 acgatttgta taatagtcaa tttgcagaga aataaacaaa aaaatccacc agttcataac
     3001 tggtggattt tttctgaatg tgatgtgcag taagagagac ttcccctgta agagaagtct
     3061 caacatcact atttattttt ccgaaggtcg tgttacgaac atggcatctc cgaaactgaa
     3121 gaagcggtag cgttcttgga cggcgtgttt gtaggcctct aggacgaatt cacgaccagc
     3181 aaaggctgaa accaacatca ccaaggttga ctttggaagg tggaagttgg ttgaaaaggc
     3241 atctacgact gtgaattgat aacctggttt gataaagata ttggtccagc ccgagtcggc
     3301 ttggagttgg ccatcatatt tatttccaat tgtttccagt gttcggattg aggttgtccc
     3361 tactgcaaca atgcgacctc cagcagcttt gacactattg agggtatcgg ccgcttcttg
     3421 gctgagggtg taaaattctg agtgcatttc atgctcgtcg acattatcga cagaaacagg
     3481 tcggaaggtt cctagtccaa cgtggagggt gaggtagacc aattttacgc ctttagcttc
     3541 aattttttga agtaactcag gtgtgaaatg gagtccagct gttggagcag cggcagagcc
     3601 attttccttg gcatagaccg tttgataacg atcgcggtct tccaattttt catggatata
     3661 aggtggcagt ggcatctcgc ctaagctttc caaaacctca aggaagatac cgtcgtagct
     3721 aaattctacg atacgtccgc cgtgatccag ttccttagtg acagtggcag tcaagcgacc
     3781 atcaccaaaa ctgactttag cacctacttt aaggcgtttg gctggtttgg ccaaaacttc
     3841 ccattggtca ccttgggtat ttttcaaaag gagaaattct acatggccgt gtgtatcagt
     3901 tttttcaccg tagaggcggg caggaagcac gcgcgtattg ttcatgacca aggcatctcc
     3961 agggttaagc tgatcaatga tgtggtcgaa gtgggtatca gtcatttccc tagttacagg
     4021 atcaatgact aagagtttag aggcgtcacg ttgttccaat ggggtttggg caattagttc
     4081 ttctggtagt tcaaaatcaa aatcgtttgt attcatttgt ttcctcgttt aaaaattttc
     4141 agccttttta ttatagcacg atatagggcg acagtcatta aacttatcaa gtgaaaacgc
     4201 ttgacaggaa ggttaaaaaa gagataataa agaaaatggt atataccaat attgaggtga
     4261 atagaatgaa aaagatttta gttaagaatc aagttgaggg aggcaaagtt gcctttgaac
     4321 ttctaaaaga gagccttaca gcgggtgctc aaacattggg attggcgaca ggtagttccc
     4381 ctatcgccct ttaccaagag atggttgaga gtgacgtgga tttttcggaa ctttacagcg
     4441 tcaatttgga tgaatacgtc ggactatcac cagagcatga gcagagctat catgccttta
     4501 tgaaggctca actctttgat gccaagccat ttaaggaaag cttcttacct gacggtatgg
     4561 ctgaagattt ggagaaggcg gctaaggatt acgatgacgt cttggcacaa catgtcattg
     4621 atctgcaaat cttaggaatc ggaagtaatg ggcatattgg ttttaatgag ccaggtacgc
     4681 cttttgatag tcaaacccat gtggtcgact tgacggatag caccattgaa gcaaatagcc
     4741 gtttctttgc cagtcgtgac caagtcccta caaaggctat ttcgatggga attgcttcta
     4801 ttatggctgc caagaagatt atcttgtttg cctatggtga caagaaggca gatgccattt
     4861 tcaagatggt caaggggcca gtgacagagg aagtgccagc tagtgtcttg caacatcatc
     4921 cagacgtgac tcttatctta gatgaggctg ctgctgcgaa attgtaggag aaaacatgag
     4981 tcgagcagat gcgagttagg taatcagaaa gttatagaaa aaaacaggtt gagctagtgc
     5041 tactcaacct gtttattaat gaataaacat aatatagatt ttgacttcaa atatttacgt
     5101 tacctaatta ttactcattt ttcatcaatt acctaaaatt ctttagtcgg aatagtccct
     5161 atttttattg gtaataaaat ctctatttga tattgtccat cttttataaa gtgtttgata
     5221 ttaccttgat attcttgaac aagagcatca atatttcgca acccccagcc atctttttga
     5281 cgggatttac gagtagattt ttctttctca tcaaaattat ttctaatatt gataaaaaga
     5341 ttttgttgaa agtatcggat attaagtgat aagtttcttt ctttatttgg tagtctgaga
     5401 caagctgtaa tactattgtc taggcagttt cctaatataa cagctaaaat atctggttga
     5461 atagataatt cttgtggtac aaagcaatca atttccattt ctatctcatc ttttaaatga
     5521 tgtagttttt gattaagtaa aaaattaata gtttgatttt tagagtagaa agtttgttca
     5581 cctactatac tatctgttaa tgaataaaga taatcttttg cctcttcagg atttttctct
     5641 aaaagcgata aaagagttaa atgtttattt tttaagtcat gccgaaggct ttggagacgt
     5701 tgatattctt cttgagattg ttgtatttct cgaacttgga actgtaattg ttctttttcc
     5761 aattggtttt ggtaatattg ctgctgttga cgagcaaggt acagattaaa ataaagagag
     5821 gagagagtta atacaatgag agatgagaga gaaatgattg acaggtaatc tgctccaaat
     5881 acccctcctt gaatggcaga tattgtaaaa gcaaagaaaa tagataaaag aggcacgata
     5941 aactgataaa gccagtttcc cttagaagta gcaatacgaa gcctttgatg ggataggaga
     6001 agctttcgta agataagagt tattcctgta gataagaaga aacttattcc gagatacaaa
     6061 ctaatagctt ctaaattttt tgatagttcc cctaaaggta aaattagttg gattccttgg
     6121 tttaggacag ctcctgctaa caaacttaga ctagtttgta aaagaatcca aaaggaagac
     6181 tggcgaatag gataatcaaa attgagaccg attagatagt attctaaaat gtttagaagg
     6241 agattactga ccaaaaaaat acgactttca gagaatagga acacgagttc cccatgaaaa
     6301 atcaatatga aaaaaagggc tactaaaggc ttctttttca tattgatttt agacaatggt
     6361 ctataaaata acatacttgc tagaaataaa tcgtacaaga tactgattat tcgtaatcct
     6421 actaacatta aaaatgcctt tcacttagat agctgtaata cttttcttta aaagaaaact
     6481 gaaactttct actaattggg agtaggtgtt cttcagtccc atttagtaaa atagtaactg
     6541 tttttgaatc aaagtctttg atgtatttgg ggtttaaaat ataggaagca tgaatttgaa
     6601 taaaataatt agggagtttt tccaaaatct cttttgtttt tagtagagac ttgtaggtac
     6661 ctgtctttgt gtatataaat actgaacgtt tatctttctc aaaaaataca atatcgctcg
     6721 aagggacaga ataattgtgt ttaccaaatg agaaggtaaa aagtgcttgg cctatatcca
     6781 aaaaacgcaa aatacgatcc aatactttca ttaacttttg aggttctatc ggttttacga
     6841 tatagtcaaa agtctgaact tcgaagactt gttccatata atcacgataa cttgtcacaa
     6901 aaataatagg aatgaaagga ttaaattttc taatcttttg tgctacgtca attccattga
     6961 ttcctggcat attgatatcc aaaaagacac agtggatgtc tggcgtcagc tgatttaaga
     7021 gtttttgtgg atttgtataa agttttgttt ctagaggaaa tttatcataa gaaagtaaat
     7081 aatgttctaa ttggctagca tctctatcag agtcatcaca aatagcaact tttaacattg
     7141 aaaacctcct cactcatttc tgtatgttag ttataacgtt aaaatggtca attatgacat
     7201 aattgtaaga aaaatgtaag tttagtatac aatattctta ttaaagatga aaggagaatt
     7261 ccaaatgaaa aacattcaag tacgtaaggc cgtagctcaa accgaaatta gctggggtat
     7321 tatttaattg cttaaaaatg ttaaataaac atataagcaa atgttacctt cgattctatc
     7381 acggaaaatt tttgatagaa ttactacaat aaggcaaggg gaaattatag aatcacctcg
     7441 tctttctttt tgaaaaatag tgaggaaaaa atgaaattcc attgtccaag aataaaagaa
     7501 atatatccta tttataaact tcacgataat ttgtttaggg taggctccca aattggtata
     7561 actactgaaa tcagtgatga ggacgataaa atgtggagtt tagttaatat tttagatgga
     7621 aggactatta atgacgttgt agatattatt taactaagta tccagatttg acggaacaag
     7681 atataatagg tgctattgaa ctattggata aggagggggt tattgaagaa ggtgctacaa
     7741 taaattgtat taaggaaaga tatcattcaa atatctacta ttttagtcgc tatttaaata
     7801 gttttaaaga tagtatagat attcaaaaga gacttaatga aacgacagtt cttttattag
     7861 gacttggcgg aggagggtcc aatatactaa ctttgctatc tggtctagga cctaaaaaaa
     7921 taaaaattgt ggactttgat atcattgaaa aaagtaatct aggtaggcaa tttttatata
     7981 aggaggaaga cgtaggggct cttaaaacac agattgccca tcaagaagtg tcaaaaatga
     8041 attctgatat cgaagttgaa actcataatt tacgtataac atgtgtaaac gacttgttgc
     8101 cattattaga caatgttgac attgttattt gtgttattga tgaaccacaa tatgatattc
     8161 agcgtattgt aaataaagct gtagttacaa aaaatattcc gtgtgttttt ggtgcaagtc
     8221 aagttagtcg cggacgtgtt tattctgtag taccccatca aacaggatgt tttgattgtt
     8281 taaacattca ttacacgaaa attgatagtc tattcttgga acaatttcgg ggtattcgta
     8341 ctgttactaa gaaaattcct acaattgctt atggtccggc tatgtttcaa ttgacatctg
     8401 ctattgttga tgaggctgtt cgattaataa ctaaatatgc agaaccaatg agtcttaatc
     8461 gccaatacga gattaattat gaaaacggag cgtcgttcac acacaaacct tggggacatt
     8521 atcctgatga gtgtcctaca tgtggtaacg gtaaggagga aaattgggaa atcttttctc
     8581 aatacggaga aataaaatta tgacttttga aacgctcacc attgaaaatt taacaaaatc
     8641 atttgataaa caacattttg ctaataacca tatcttctta gagctagaag ctgcaaaaat
     8701 cacagctctt ataggacata atggtgctgg taaatcaact cttttaaagc aaatgattgg
     8761 ttttattaag cctgatcagg gagatgttca ctacggagat atttctttta tacataaccg
     8821 taaacaagct cgaacaatga tgagttatat gtcacaacag tatgcacctc ttgaaaagtt
     8881 aactgttgag caaaatttag agatgattgg aagaatgaga gggttaagta cctcagaact
     8941 ccaaaaagaa attgagcacc ttctagcaga tctggaaata gtagaatacc gtgataaaaa
     9001 agggaagaat ctttcaggag gcttaaaacg gcttacatct tttgccatgg cattaattgg
     9061 ctctgctgat atcatgcttc ttgacgaacc aaccaacgat gttgatcctg tacgtcgtga
     9121 aaaacagtgg cgattattac aaaaactggc ttataaagga cacactatta tcattgttac
     9181 ccacaatcta ctagaagttg aaaaatatgc ggataatttt gctcttttta accatggtaa
     9241 attattaaaa tctggtccag tacaccaaat gtcttataaa aatcattatc aaatttcttt
     9301 caattttgtt agtaaagaat ttttaagtct attcgaacat tttacgatgg tcaatggttg
     9361 tgtttgtcag atggaaattg aagaaagtga attaacccga atactcattc aagttaagga
     9421 aggtatagaa aaagggctta tttcaaacct ttcagttaag atgaaaacat tatctatttc
     9481 cgatctttat aaagaggagc ttgttaactg atatgactca atttttttac ttacttcgtt
     9541 ggaactatct tcgacaaaaa aatctattca ttctattcac actagctcaa gtgcttttgt
     9601 ccgtttcact tctttttggg tatccgttgg taattggtaa gatggacaca acaactgctt
     9661 actatcttgc ctctggatca gttttaatgg gagttatttc tattggctgt acgatttcat
     9721 ctcctgttat agccaatgcc aagtcagaag gtcatgtgga ctatattcga gctttaccta
     9781 ttcctagaat tctaatttct ttagctgacc tatgtatatg gttaattgct attttaccag
     9841 gtgtattctt cactttttta ttaggctgtc ttcgcttttc tgtccaatta aatttgtcaa
     9901 ttttgtctgt ttttgtgatg ttacttattt gcctaacaat gattagtcta ggattttcaa
     9961 ttgcttatat attttcccaa aatattgtca cgctaatgtc tcagcttatt ttaatgattg
    10021 gtcttatgtt ttcaccaatc atgtatccgg caggtcgtct tccagattgg ttagatcaac
    10081 tttattttct acttccattt gtcccttctg cgaatcttct tagagctagc ttttatagac
    10141 atggaactgt ttcgcttgta gatataggag ttcttatttt ctggattttt ctgacacaac
    10201 tgcttatctt agggacacta cagaaagagt tgtaatacta tcttgtgaaa aaataatccc
    10261 ataaaactta ggttgaggca tttggcactt agcctttttc tgttgtgaaa attcttctcc
    10321 aaacaaatca attgcctagt cctctttgat aacggtataa tagttaagtt gattttatta
    10381 tcaaacaaca aatatagata tttcataaag aaagaggaag tacaatggca aaacctattc
    10441 gagtattgct ttattataaa tacgttccca tcgaaaacgc tgagcaattt gcggctgacc
    10501 acttggcttt ttgtaagtca atcggtctaa aaggtcgtat cttggtcgct gacgagggga
    10561 ttaatggaac ggtttctgga gactatgaaa ccactcaaaa atatatggac tacgtccaca
    10621 gccttccagg gatggaggac ctttggttca agattgatga ggaagaagag caagccttca
    10681 agaagatgtt tgtgcgttac aagaaggaaa tcgttcacct tggtttagag gacgataact
    10741 ttgatagcga catcaatcca cttgaaacta caggtgctta cttgtcaccc a
//
