LOCUS       gnlProkkaFEPJNGBC_1    13333 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FEPJNGBC_1.
ACCESSION   gnlProkkaFEPJNGBC_1
VERSION     gnlProkkaFEPJNGBC_1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 17:23:17
            Original ID  :: gnl|Prokka|FEPJNGBC_1
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 3828283
            Orig. end    :: 3841616
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13333
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:8333]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..8333
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..13333
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13333
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="9"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     CDS             complement(424..2304)
                     /locus_tag="ctg1_4029"
                     /transl_table=11
                     /translation="MAKKEFKAESKRLLDMMINSIYTQKEIFLRELISNSSDAIDKIYY
                     KALTDDALTFDKDSYYIKVAADKDARTLTISDTGIGMTKDELEQHLGTIAKSGSLAFKK
                     ENELKDGHDIIGQFGVGFYAAFMVADVVTVISKALGSEEAYKWESAGADGYTIEPCEKD
                     SVGTDIILKIKENTEDDSYDEFLEEYRLKAIIKKYSDFIRYPIKMDTTINKPKEGSENE
                     FEEVQEEQTVNSMVPIWRKNKSELTDEDYEKFYAEKHYGFDKPLTHVHISVDGAVRYNA
                     ILFIPENMPFDYYSKEYEKGLELYSNGVLIMNKCADLLPDHFSFVKGMVDSEDLSLNIS
                     REMLQHDRQLKLIAKNISKKIKSELQSLLKKDREKYETFYKSFGRQLKFGVYNDFGANK
                     DQLKDLLLFYSSKEKKLVSLDEYVSRMPEEQKYIYYATGDSYDRIEKLPQTEMVADKGY
                     EILYFTEDIDEFAIKMLASYQEKEFKSVSSGDLGIDTDEDQKQSEEEENKYKDLFKEMN
                     NILSDKVKNVRISKRLKSHPVCLAADGEVTIEMEKILNAMPDSQNVKAEKVLEINPNHE
                     VFQTLQDAFEQDKEKLSLYTNLLYNQALLIEGLPIQDPVEFTNNICKVMV"
     CDS             complement(2472..2723)
                     /locus_tag="ctg1_4030"
                     /transl_table=11
                     /translation="MKVQHKKELKFYCFITIPSAFVVLTVISFLLQEITFPVTASAFLN
                     ASWHNLLFLIPFGLFFYPVHIWMKREFGRWNDTEKKRG"
     CDS             2826..3026
                     /locus_tag="ctg1_4031"
                     /transl_table=11
                     /translation="MGRLENKTAVITGAATGIEQATAEVFANEGARVMIGDINTDQMEE
                     TVDAIRKKRRTGRILSPRCVR"
     CDS             2965..3648
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     183.3; E-value: 9.1e-56)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_4032"
                     /transl_table=11
                     /translation="MTQSEKNGGQAESFHLDVSDENSVKAFADQIKDACGTIDILFNNA
                     GVDQEGGKVHEYPVDLFDRIIAVDLRGTFLCSKYLIPLMLDNGGSIINTSSMSGRAADL
                     DRSGYNAAKGGITNLTKAMAIDYARNGIRVNSISPGTIETPLIDKLAGTKEQEMGEAFR
                     EANKWVTPLGRLGQPKEMATVALFLASDDSSYVTGEDITADGGIMAYTWPGKMLIDEKW
                     KEETK"
     CDS             3915..4115
                     /locus_tag="ctg1_4033"
                     /transl_table=11
                     /translation="MNNKVKIERLTLGLTQADLAKKLGITRQTVSLIEKGHYNPSLNLC
                     IRICNVFKKTLDDVFWPSDNL"
     CDS             4133..4534
                     /locus_tag="ctg1_4034"
                     /transl_table=11
                     /translation="MIDERIQQEQHKLSYYSFGLSIILFILSFFVSILTQNLFYTQLSI
                     IISFMVVSTYYSIFAIKRGLIIKRKNSNLKHFYIFILSGMFWIIISFLSKEINNMKELL
                     IQLLFFSLFYTVIFLSIRSIIKYSHKQSN"
     CDS             complement(4738..4956)
                     /locus_tag="ctg1_4035"
                     /transl_table=11
                     /translation="MLHNIENSNKMIELSEQEMLNTDGGGWRDLAGAAAGAAVMGGTAI
                     ALGAAAGPVGFAAGVGMAILTRPGHAR"
     CDS             complement(5001..5222)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_4036"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 2.5e-08,
                     bitscore: 32.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKQNTNFELLTVEEAEKIDGGGYGSYLIRGVGTGTAVGAALGGP
                     GGAVLGANVGAIWGSAAYGVDALISGHK"
     CDS             5732..5986
                     /locus_tag="ctg1_4037"
                     /transl_table=11
                     /translation="MEFLYILVESVIWILITTIPSKRNLKFRRNLKTLKKHAWFRNLMK
                     DYRPLFLMNSTIQNKIIEYNENIDSKTFKMELEQLAKNI"
     CDS             6150..8333
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="resistance (resist) ABC_efflux (Score:
                     248.8; E-value: 6.5e-76)"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 300.9; E-value:
                     3.1e-91)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_4038"
                     /sec_met_domain="Peptidase_C39 (E-value: 3.8e-43, bitscore:
                     144.5, seeds: 36, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR01193 (E-value: 1.1e-235, bitscore:
                     782.3, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MILKKYHCVKQMDDKDCGAACLATILKHYGSKISLAKIRNIAGTD
                     TQGTNVLGVIKAAETLGFSAKGVKADQTAFEQPFPLPAIAHVVLNGQLLHYMVIHKIKK
                     DKIIIADPGKGIITYRKDEFFKIWTGILIFMVPSDTYQQQTDIRSVKKDILNLILHQKS
                     LIIHTALASFIITIFGILSTFYFQTIIDQILPNGLKNSLHIISIGLIIMYLFKVLLTAF
                     RQYLMILLGQKLSISIMLGYFKHVLKLPMKFFSTRKDGEILARFNDTNKVIDAIVSASL
                     SAVLDTFMLIMVGIFLYIQNTSLFIVTLALIPFYILTVWVFMKPYESINDNEMENNAQL
                     TSKIVETLSSIETIKAYNAEYIMSFETEKRFVKYLQSSFKHGVIDNLQSSIKLFLDLIS
                     GALILWIGAWQVIKGNMTIGQLITYNALLAYFLNPLQNIISLQSKLQSASVASKRLGEI
                     LDEEPEIQTSEARVTDPAYIQGPIEINNVDFRYGTRRLILKDITLHIQKGEKVAFVGES
                     GSGKSTLTKLLMKFYTAESGEILINGYHINDIHTNALRESISYIPQESHFIQGSILENL
                     LLGNSGSFTFEEIIEVCKQTNVHDFVNDLPMRYDTLVEENGSNLSGGQKQRLAIARALL
                     RKPNILIMDESTSNLDTTTEQGISKMIYAQTVDVTTIIIAHRLSTIMNCDKIFVMENGE
                     IIEYGNHNDLLKKKGKYYELWENQMPSREMVTI"
     CDS             8334..9803
                     /gene_functions="transport (smcogs) SMCOG1029:RND family
                     efflux transporter MFP subunit (Score: 77.5; E-value:
                     1.5e-23)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_4039"
                     /transl_table=11
                     /translation="MKRNFFNLHDLKDSREFYESKPKPIGVFFTYILIALLIACIVFSF
                     YGKKEVILKTAADIQYTKPNSNVTNEVAGKVKTVDIKQVDKVKKGDTLLTLDNTEIQAQ
                     KKAVKADIKDVKEQAALNKTLKKSIENDKNLFSEDDHWGYQDQYLSYEKQSNLLESSKE
                     NAKTQQKKLKKQKKSIKNSLDKTKNKVKRKLQRISDLQDSIKNNKSFAKQDDKYSSYYN
                     SFQTNKQNVEQQLDDLRKMKDELDKNSFSQKKENLNGQLESLKQDMLVKLSEEKDELNQ
                     SFDEINSSMKSDDSDSDSDNSEETNYKLSIEQLKTNLLNQTSQKQTDLQTTLKSKEDDL
                     KMIDLQLEKYKIKATSDGYVNVLTNISPGDYLQAGTAILTIVPDKEKLKANIYIPSHEI
                     TNINEKDEVRFHIENTNQTVKGVITKISPDSISDQSGQKFYIAESTIESKEIEKNNGTK
                     IHLKNGMQTDVSIIVDSKRYIDYFLDVLHLR"
     CDS             9905..10093
                     /locus_tag="ctg1_4040"
                     /transl_table=11
                     /translation="MSQNKLLFLLFLFSSIVRLFFNTVLSPTVSWKSWTVNIVFILLFL
                     LFLNLTLKERKSKDQVL"
     CDS             complement(10212..11246)
                     /locus_tag="ctg1_4041"
                     /transl_table=11
                     /translation="MKTLCTHSLPKEKMPYLLRSGEGERYLFGRQVATVMANGRSTGDL
                     FEIVLLSGGKGDAFPLHVHKDTHEGILVLDGKLELTLDGERYLLISGDYANIPAGTPHS
                     YRMQSHRTRLVSYTMKGNVAHLYSVIGNPYDHAEHPPYASEEVSNERFAEAAAVADIVF
                     LDEGKPACSAKLAELTELPDGAVPYVLESGEGDRLLTGDQLHRIVAAQKNTDGQFIVVS
                     SEGPKGDRIVDHYHEHHTETFYCLEGQMTMWADGQEIQLNPGDFLHVPANTVHSYRLDS
                     HYTKMVGVLVPGLFEPFFRTLGDPYEGHIFPCEPQALHFDRVLQNIEALDLKVDYRADI
                     VSAR"
     CDS             complement(11340..11915)
                     /gene_functions="regulatory (smcogs) SMCOG1057:TetR family
                     transcriptional regulator (Score: 64.7; E-value: 2.4e-19)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_4042"
                     /transl_table=11
                     /translation="MTSRGDSREKILHTASRLFQLQGYHATGLNQIVKESGAPKGSLYH
                     FFPNGKEELAIEAVTYTGKIVEHLIQQSMDESSDPTEAIQLFIKKTASQFDNTESIKGI
                     PVGLLASETALISEPLRTVCMKVFKSWEAVFARKLMENGFADEEANQLGTLINSMIEGG
                     IMLSLTNKDKTPLLLIAEQIPVLVRKKG"
     CDS             12046..13116
                     /NRPS_PKS="Domain: PKS_KR (32-194). E-value: 5.4e-10.
                     Score: 31.3. Matches aSDomain:
                     nrpspksdomains_ctg1_4043_PKS_KR.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     181.7; E-value: 2.8e-55)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_4043"
                     /sec_met_domain="adh_short (E-value: 2.1e-30, bitscore:
                     104.0, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIDHSVTNTEQLERQNPAIKTKLKLKKLKDQVIVITGASSGIGL
                     VTARMAAEKGAKVVAAARNEDALKELTDELKEKGHDAIWVKADVGKEEDVNRIAETAIS
                     TFGRFDTWVNNAAVSTFGHAMDVTVEDMKRMFDTNFWGPVYGTRAAVKHYTGRGVPGAL
                     INVGSLFGDRGTVIQSTYASAKFALHGWTESIRMELEKEQAPVSVTLIHPGRIDTPYNE
                     HAHSYLDKQPAHYRSMIYPPEAVAEAILFAAEHPKRDMYIGSQAKAIAMLGALFPRLTD
                     RLMEKIMYHSQHAEKPSKPREESALYDAGCGMHDRGTNKGWMRSRSYYTNATKRPIVSA
                     AVVAGLVAWAAAKRCR"
     aSDomain        12142..12627
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg1_4043_PKS_KR.1"
                     /evalue="5.40E-10"
                     /label="ctg1_4043_PKS_KR.1"
                     /locus_tag="ctg1_4043"
                     /protein_end="194"
                     /protein_start="32"
                     /score="31.3"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VIVITGASSGIGLVTARMAAEKGAKVVAAARNEDALKELTDELKE
                     KGHDAIWVKADVGKEEDVNRIAETAISTFGRFDTWVNNAAVSTFGHAMDVTVEDMKRMF
                     DTNFWGPVYGTRAAVKHYTGRGVPGALINVGSLFGDRGTVIQSTYASAKFALHGWTES"
     CDS_motif       12145..12222
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg1_4043_0001"
                     /evalue="1.30E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg1_4043"
                     /protein_end="59"
                     /protein_start="33"
                     /score="17.8"
                     /tool="antismash"
                     /translation="IVITGASSGIGLVTARMAAEKGAKVV"
ORIGIN
        1 tcaacagcgt ggatgacagt agtctttcta ggtgtctata tcgtctttta ccaggcgaca
       61 tggggtccgg tagtgtgggt gctcatgcct gagctcttcc catccaaagc acgcggagcc
      121 gcgacagggt tcacgacttt ggtgttatcg gcggctaacc tgatcgtgtc gcttgtcttc
      181 ccgctgatgc taagcgcgat gggcatcgca tgggtcttta tggttttctc agtcatttgt
      241 cttctctcat ttttcttcgc gttctacatg gtaccggaaa ccaaagggaa aagcttggag
      301 gaaattgaag caagcctgaa aaaacggttt aaaaagaaga aaagcaccca aaaccaagtg
      361 ctgaatgagc gtactttata aaaaaaagga atcgtctcct taagggacga ttcctttttc
      421 tgtttacacc atgaccttgc aaatattgtt cgtaaattca acagggtcct gaatcggcag
      481 gccttcaatg agaagcgcct gattgtacag aaggtttgtg tacaggctca gcttctcttt
      541 atcttgttca aacgcgtcct gcagcgtttg gaatacctcg tgattcgggt tgatttccag
      601 cactttttcc gccttcacat tttggctgtc aggcattgcg tttaagattt tttccatctc
      661 aattgtcact tcgccgtcag cagcaaggca gactggatgt gatttaagcc gttttgagat
      721 tctgacgttt ttcactttgt ctgacagaat gttattcatt tccttaaaca gatccttata
      781 cttgttttcc tcttcctcgg actgcttttg atcctcatcc gtgtctatgc caaggtctcc
      841 gcttgatacg gacttgaatt ctttttcctg ataagaagcc agcattttaa ttgcaaactc
      901 atcgatgtcc tcagtaaagt agaggatttc atagcctttg tccgccacca tttccgtttg
      961 cggcagtttc tcaatgcggt cgtaagaatc accggtcgcg taataaatgt atttttgctc
     1021 ctctggcatt ctggaaacat actcgtctaa gctgaccagt tttttctctt ttgaagagta
     1081 gaataatagg agatccttca attgatcctt attcgcgcca aaatcattat acacgccgaa
     1141 tttcagctgt ctgccaaacg acttgtagaa cgtctcgtat ttctcgcggt cttttttcaa
     1201 caggctttgc agctcgcttt tgattttctt gctgatgttt ttcgcgatca gcttcagctg
     1261 gcggtcatgc tgcagcattt ctctggaaat attcagcgac agatcctcgg aatcgaccat
     1321 gcccttcaca aagctgaagt ggtccggtag caggtctgcg cacttattca tgatcagcac
     1381 gccattggaa tacagctcca agcctttctc atattccttg gaatagtagt caaacggcat
     1441 gttttcaggg atgaatagaa tcgcgttgta gcgaaccgct ccatccacac tgatatgaac
     1501 gtgtgtcagc ggtttatcaa acccgtaatg cttttcagca tagaattttt cataatcctc
     1561 atctgtcagc tcgcttttgt tttttctcca gatcggcacc atgctgttga ccgtctgctc
     1621 ttcctgcacc tcttcgaatt cattttcgct gccttccttc ggcttattaa tggtcgtatc
     1681 cattttgatc gggtagcgaa tgaagtcgga gtacttcttg atgatcgctt ttaaacgata
     1741 ttcttctaag aattcgtcat agctgtcatc ttctgtgttc tctttgattt tcaggataat
     1801 gtctgtaccg acagaatcct tttcacacgg ctcaattgta tagccgtctg cacccgcaga
     1861 ctcccattta taagcctctt cgctgccaag cgctttactg atgactgtca cgacatcggc
     1921 aaccataaat gccgcgtaaa aaccgacacc gaactgcccg ataatgtcat gtccgtcttt
     1981 cagctcgttt tcctttttaa acgcgaggga accgcttttt gcaattgttc caagatgctg
     2041 ttcaagctca tcctttgtca ttccgatccc cgtatcagag atggttaatg ttctcgcatc
     2101 tttgtcagct gcgaccttta tgtagtaact gtctttatca aacgtaagcg catcgtccgt
     2161 aagcgctttg taatagattt tgtcaatcgc atcactcgaa ttggagatta actcgcgcag
     2221 gaaaatttct ttttgggtat aaatggagtt aatcatcata tccagcaagc gtttagactc
     2281 tgctttaaac tcttttttcg ccactcttga tcgctccttt accattatgt aaaccctttt
     2341 tagcatctat ttatcacata agatgacaat tgtcaattag attgatagat gcatatatat
     2401 gtaaatttaa cattagttgg atttgttttc actctttttc tcactcattc tcataaaaaa
     2461 gagaggcttc atcatcctct ctttttttct gtgtcattcc agcggccaaa ctcccgcttc
     2521 atccatatat gcaccgggta gaaaaacaaa ccgaacggta tcaaaaacaa aagattatgc
     2581 catgaagcat tcagaaatgc gcttgcagtc accggaaacg taatctcttg caataaaaaa
     2641 gagatgacag tcagcacaac aaacgccgat ggaatcgtga taaagcaata aaacttgagc
     2701 tccttcttat gctgtacttt caaaacacac aaccctccca acaatttccc aatccatctt
     2761 aacatatgtt ggcagttctt tttcttcatg tttatcactg ccaaatagaa aaaggaggtc
     2821 tcgtcatggg aagacttgaa aacaaaaccg cagtgatcac aggcgccgcg acaggcattg
     2881 aacaagcgac ggcagaggtt tttgccaatg aaggcgcgcg tgtaatgatc ggagacatca
     2941 atacagatca aatggaagaa acagttgacg caatcagaaa aaaacggagg acaggccgaa
     3001 tcctttcacc tcgatgtgtc agatgaaaac agtgtgaaag cttttgctga ccaaatcaag
     3061 gatgcatgcg gaacgattga tattctgttt aataatgccg gcgttgatca ggagggcgga
     3121 aaggtgcacg aatatccggt tgacctgttt gaccgcatta tcgccgtcga cctgcgcggc
     3181 acgttccttt gcagcaaata tctgattccg ctcatgctcg acaatggagg ttctatcatc
     3241 aacacctcct ccatgtcagg ccgcgccgcg gatcttgacc gctccggcta taacgcggca
     3301 aaaggcggta tcaccaacct gacaaaggca atggcaatcg actacgcacg gaacggcatc
     3361 cgcgtcaatt ccatttcacc aggtacgatc gaaaccccgc tgattgacaa attagcaggc
     3421 accaaagaac aggaaatggg cgaagcattc cgcgaagcca acaaatgggt cacgccgctc
     3481 ggccgccttg gccagccgaa ggaaatggcg acagtagcgc tgttcctcgc gtcagacgac
     3541 agctcatacg tcacaggaga ggacatcacc gcagacggcg gcatcatggc atatacatgg
     3601 cctgggaaga tgctgattga tgagaaatgg aaggaagaaa cgaaataacg ttagctcaaa
     3661 gagggataaa acgccctctt tttttaattt ccgaatgcaa acgaaacaaa aaaaacactc
     3721 ctatttatga cttttttcaa tctaaaacct tgaacattga atattagtca ggctccgact
     3781 atctcagtaa tatgtttcat ttaagaatat ctccaaaaga ctcctttcag ttttaacaat
     3841 ttcatcctat caatgtaata tatattgtac ataaagtaat atatatgtta cgatcattaa
     3901 taaaggagga tgccatgaat aataaggtta aaattgaaag attaactctt ggtttaactc
     3961 aggctgattt agctaaaaaa cttgggataa caagacaaac tgttagctta atagaaaaag
     4021 gtcattacaa tcctagttta aatttatgta taagaatttg taacgttttt aaaaaaactt
     4081 tagatgatgt tttttggcct tcagataatt tatagaggag tgcatagtta gaatgattga
     4141 tgaaagaata cagcaggaac aacataaact gagttattac agttttggtc tgtctataat
     4201 tttatttatt cttagttttt ttgtttctat tctaacccag aacttatttt acacccagtt
     4261 aagtataatt atatcgttta tggttgttag cacttattat tcaatttttg ctataaaaag
     4321 gggcttaata ataaagagaa aaaacagcaa tttaaaacac ttttatattt ttatactgag
     4381 cggaatgttt tggataataa taagttttct ttctaaagaa ataaataata tgaaagaatt
     4441 actgattcag ttactatttt tttcactctt ctacactgtt atatttctaa gcatccgttc
     4501 tataattaag tattcacata aacaatctaa ttagtacata atttaaatta ggttataacc
     4561 ttttaaggaa agtgtttaac actaatagta ataggagtat attaacctac agattttttc
     4621 aaagtattaa cataacccct cactacaaaa ctgttggtaa aggtatgaag ttgagccctc
     4681 aaataattgt aaaagaaaaa gctgtcgtca tttatcgaca gctttctata agataagtta
     4741 tctagcatga cctgggcgag ttaagattgc cattcctact cctgcagcaa atccaactgg
     4801 cccagcagcc gctcctaaag caatggccgt tccacccatt actgcagctc ctgcggcagc
     4861 tcctgctaaa tctctccacc ctcctccgtc agtatttaac atttcttgtt cactcaattc
     4921 aatcatttta ttactatttt cgatattatg taacatgcta aacctcctgt ttttttacgt
     4981 ttatattagt gaaattttaa ttacttatgt ccagaaatca atgcatctac accgtacgct
     5041 gcagaacccc agatagcccc aacgttagca cctaaaacag ctccgccagg cccgcctaaa
     5101 gctgctccca cagcagtgcc tgttccaact cctcttatta aataagaacc ataaccccca
     5161 ccatctatct tttcagcttc ttctacagtt aataattcaa aattggtgtt ttgctttttc
     5221 atagtttact cctcctaagt ccgaacttgg taaattattg tcgacttata ttactataaa
     5281 tgtaatttga agttttttca acagttataa ccaaatttat attacttaat acatctaaaa
     5341 tgcctataat ttctttaatt acttaatatc ctagagtcgc tatgtaattg aatatttgac
     5401 taaattccac tagtgtcgca ttaaaataat tcaacgattt ataaaaatct aaattttcag
     5461 taattttatc tttgcataaa aaaagccttt ataatggtag ggggatgtta actacctcta
     5521 ttcaaatgtc tttgtttttc ttctcatgag caaaaacaag aaagcagaaa attcagtcaa
     5581 aatttatgca acactagtga ctaaattcat ataataacta actacttgaa actttaacca
     5641 aagttttttt tatgttaatc tagaaaagga ttttttatga aaaattaatt ttaatatcat
     5701 aatgttttat tagcataagg aggttaattt gatggagttt ttgtacatat tagttgagag
     5761 tgtgatatgg attttaatta ctaccatacc atcaaaaaga aacttgaaat ttagaagaaa
     5821 cttaaaaaca ttaaaaaaac atgcttggtt tcgcaattta atgaaagatt acaggcccct
     5881 gtttttaatg aactcaacta tccagaacaa aattattgaa tataacgaaa atattgattc
     5941 taaaactttt aagatggagt tagaacaact agcaaaaaac atataagtgt gaaaagtatg
     6001 tacaattaat aatctaaatt tcatcgtacc tttacacaaa aaagttatat ttcaccttaa
     6061 attatcgata tatgtattac tgttatatta tgattataaa gttccgcata attttacgga
     6121 ttaaattttt taactacgga gattagaaaa tgattttaaa aaaatatcac tgtgtaaaac
     6181 aaatggatga taaagattgc ggtgctgcgt gtttagcaac gattctaaag cactatggat
     6241 caaagatatc actagcgaaa attcgaaata ttgctggcac agatacacaa ggtactaatg
     6301 ttcttggtgt aataaaagca gcagagaccc ttgggttttc tgcaaaagga gttaaagctg
     6361 atcaaacagc tttcgaacaa ccgttccctc ttccagctat tgcacatgtg gttttaaatg
     6421 gtcaattatt gcattacatg gtcatacaca aaattaaaaa agataaaatt attattgctg
     6481 atccaggaaa aggtataatc acctatagga aagatgaatt ttttaagatt tggaccggaa
     6541 ttttaatttt tatggttcca agtgatactt atcagcaaca aacagacatt agaagtgtta
     6601 aaaaagacat tttaaattta atacttcatc aaaaatcttt aattatacat acagcattag
     6661 catcttttat tattacgatc ttcggtattc tgagcacttt ttattttcag acaatcattg
     6721 atcaaatttt gcccaacggt ttgaagaact ctttacatat tatttctatt ggacttataa
     6781 taatgtacct atttaaggtt cttttaacag cttttagaca atatttaatg attctattag
     6841 gtcaaaaatt aagtatatcc attatgctgg gttactttaa gcatgttctt aagctgccta
     6901 tgaaattctt tagcactaga aaagatggtg aaattttagc tagattcaat gatacaaata
     6961 aagttattga tgctattgtc agcgcatcct tgtccgcagt gctcgataca tttatgttaa
     7021 tcatggttgg gatcttttta tatattcaaa atacttcttt gtttatagta acattagctt
     7081 taatcccctt ttatattcta actgtttggg tttttatgaa gccctatgag agtattaatg
     7141 acaatgaaat ggaaaataat gctcaactca cttcaaaaat tgttgaaaca ttaagtagta
     7201 tagaaacaat aaaagcttac aatgctgaat atattatgtc atttgaaact gaaaagcgat
     7261 ttgtgaaata cttgcaatct tcttttaaac acggtgtaat tgataatctt caaagttcta
     7321 ttaagttgtt tctagattta ataagtggtg cattgatact atggatcggc gcttggcaag
     7381 tcataaaggg aaatatgaca attggccagt tgattacata taacgcacta ttggcatatt
     7441 ttttgaaccc tttacaaaat atcatctcac ttcaatccaa acttcagtca gcttcggttg
     7501 cttcaaagag attgggagaa attttagatg aagaacctga aatacaaaca tctgaagcaa
     7561 gggttaccga tccagcctat atacaaggcc ctattgaaat aaacaatgtt gattttcgat
     7621 acggaactcg aaggctcatc ttaaaagata ttacactgca tattcaaaaa ggagagaaag
     7681 ttgcctttgt tggagaaagc ggttcaggaa aatctacttt gactaagctt ttaatgaaat
     7741 tttatacagc tgaatcaggt gagattttaa tcaatggtta tcatataaat gatattcaca
     7801 ccaatgcgtt aagggaaagc ataagttata tacctcaaga atctcatttt atacaaggat
     7861 caattcttga aaaccttttg cttgggaact caggaagttt taccttcgaa gagattatag
     7921 aagtttgcaa acaaacaaat gtacatgatt ttgtcaatga tttaccaatg agatacgata
     7981 ctctcgtaga ggaaaacggg tctaatttat ctggaggcca gaagcaaaga cttgcaattg
     8041 ccagggcatt attaagaaaa cctaacattc ttataatgga tgaatcaaca agcaacctcg
     8101 atacgacgac cgaacaggga atatcaaaga tgatttacgc tcagactgtc gatgtaacta
     8161 caattataat tgctcatcgt ttaagtacaa ttatgaattg cgacaaaata tttgtcatgg
     8221 aaaatggaga aatcatagag tatgggaacc acaatgattt attgaagaaa aaaggaaagt
     8281 actatgagtt gtgggagaac caaatgccat cgagagagat ggtgacaatt tagatgaaac
     8341 gtaacttttt caatttacat gatttgaagg atagcagaga attctacgaa tcaaaaccca
     8401 aaccaattgg tgttttcttt acatatatac tgatagcttt acttattgca tgtattgttt
     8461 ttagtttcta tggaaagaaa gaagtgattc taaaaacggc agctgacatc caatatacga
     8521 aacctaacag caacgtaaca aacgaagtag ccggcaaagt aaaaacagtt gatattaaac
     8581 aggttgataa ggtgaaaaag ggggatactc tattaactct agacaatact gaaatccaag
     8641 cgcagaaaaa agctgttaaa gcagatatca aagatgtaaa agaacaagct gcgttaaaca
     8701 aaactctaaa aaaaagtatt gaaaatgaca aaaatttatt cagcgaggac gatcattggg
     8761 gttatcaaga tcaatatctc tcatacgaaa aacaaagcaa tttgttagag tcatcaaaag
     8821 aaaatgcaaa aactcaacag aaaaaactta agaagcagaa aaaaagcata aaaaatagtc
     8881 tcgataagac aaaaaacaaa gtgaaacgaa agcttcaaag aatttctgat ctgcaagact
     8941 ccattaaaaa caataaatcc tttgccaaac aggatgataa gtacagttct tactataata
     9001 gttttcaaac taacaaacaa aatgtagagc agcagcttga tgatctacgg aagatgaaag
     9061 atgagctcga taaaaacagt ttctcacaga agaaagagaa tctaaacgga cagcttgaaa
     9121 gtttaaaaca agatatgcta gtaaaactaa gcgaagaaaa agacgaatta aatcaatcat
     9181 ttgatgagat taacagttca atgaaaagtg acgattctga cagtgattcc gataactcag
     9241 aggaaacaaa ttataagctt tcaattgaac agcttaaaac aaatttgcta aatcaaacat
     9301 ctcaaaagca aacagatctt cagaccactc ttaaatcaaa agaagatgat ctaaagatga
     9361 tagatttaca attagaaaaa tataaaataa aagcaacaag tgacggctat gttaatgtat
     9421 taacaaatat atctccaggt gattatttac aagcaggcac cgccattttg actattgttc
     9481 ctgataaaga gaagcttaaa gctaacattt atattccgag tcatgagatc acaaatataa
     9541 atgaaaaaga tgaagtaaga ttccatattg aaaatacaaa tcaaaccgtt aaaggtgtca
     9601 ttacaaaaat aagtccagac agtataagtg atcaaagcgg gcaaaaattt tatattgctg
     9661 aaagcacaat agaaagtaaa gaaattgaaa aaaataacgg aacaaaaata cacttaaaaa
     9721 atggcatgca gactgatgta tcaattatcg ttgattccaa aagatatatt gattattttt
     9781 tagatgtatt acacttacgt taatttccat ctagagaaaa agtgcatata tgtctcaaaa
     9841 gcagatgagg atctgctttg aggcatttta ttttttataa gaaaggcaga ggacgtatag
     9901 aatcatgtct caaaacaaac tgttattttt actcttttta ttctcttcta tcgttcgcct
     9961 tttcttcaat acagtattgt cccccactgt aagctggaag tcttggacgg tgaatattgt
    10021 ttttattctt ttgtttcttc tatttctcaa tctcacctta aaagaaagaa aatcaaaaga
    10081 ccaagtatta taacgaccca aagcccggat caagtctccg ggcacttcaa agcaaaacaa
    10141 ccttatactt cttcacatcc aaaaactgca aaaactccct cgccagcact tccggcgcat
    10201 gcgccttccc ttcatcgagc cgatacaata tcagcccgat aatctacctt taaatctaat
    10261 gcttcgatat tctgcaaaac gcgatcaaag tgcaaagcct gaggctcaca tgggaagatg
    10321 tggccttcat acgggtcgcc taacgtccgg aaaaacggtt caaataaacc aggaaccaat
    10381 acgcccacca tctttgtata gtgagaatca aggcgatagg agtgaacggt atttgcaggg
    10441 acatgcagga aatctcccgg attcagctga atttcctggc catctgccca catcgtcatc
    10501 tgaccttcaa ggcaataaaa tgtttctgta tgatgttcat ggtagtgatc aacgattcgg
    10561 tcacctttag ggccttcaga ggatacgacg ataaactggc catctgtatt tttttgtgca
    10621 gccacaatgc ggtgaagctg atctccagtc aacaggcgat ctccttctcc agattcaaga
    10681 acgtatggaa ccgctccatc tggcagctct gtaagttccg ctaatttggc cgaacatgca
    10741 ggctttcctt catctagaaa tacaatgtcc gctacagcgg ctgcttctgc aaatcgctcg
    10801 tttgagactt cttcgcttgc gtacggcgga tgttcagcgt gatcatacgg attcccaata
    10861 acggaataca agtgcgctac gtttcctttc atcgtgtagg acaccagtct tgttctgtgg
    10921 ctctgcatcc ggtagctgtg cggtgttccc gccggaatgt tggcataatc acctgatatt
    10981 aataaatagc gttcaccgtc aagtgtcagt tccagtttcc cgtccaaaac gagaattcct
    11041 tcatgtgtgt ccttgtggac gtgaagcgga aaggcatctc cttttccccc ggaaagaagc
    11101 acgatctcaa acaaatcacc tgtgctcctc ccattcgcca tcaccgtggc aacctgtctg
    11161 ccgaacagat agcgctcgcc ttctccgctc cggagcaaat aaggcatttt ttctttaggc
    11221 aatgaatgtg tacataatgt tttcatatta tcgcttcctc caatttagac cagtctatat
    11281 attatcattt atttgtctag accgttctat ataattgtag gagaaaggat aacaaaatgc
    11341 tacccttttt ttctcaccag cactggtatt tgttcggcaa tgagaagaag aggcgttttg
    11401 tctttattcg ttaacgaaag catgatgccg ccctcaatca tcgaattaat cagcgttcca
    11461 agctgatttg cttcttcatc tgcaaatccg ttttccatta attttctggc aaaaaccgct
    11521 tcccagcttt taaacacctt catgcaaacc gtccgcagcg gttcactgat taacgctgtc
    11581 tcactcgcca gcaaaccgac tggaatacct ttaatgcttt ctgtgttatc aaattggctg
    11641 gctgtttttt tgataaaaag ctgaatcgct tctgttggat cagaggattc atccatgctt
    11701 tgctgtatca gatgttcaac gatcttacct gtatatgtaa ccgcttcaat tgctaattct
    11761 tctttgccat tcggaaaaaa gtgataaagc gatcccttag gagcaccgct ttcttttaca
    11821 atctggttca aacctgtcgc gtgatatcct tgcagctgga acagacgtga cgccgtgtga
    11881 aggatttttt cacgtgaatc tcctctgcta gtcattaaaa cattccctcc taggtatggt
    11941 agagcgactt atataatata aaaaagaacc ctgtgattgt caaaaggggt aagacccttc
    12001 cggatggggt aatgtacaaa aacagcgtct aggagggatc tctcaatgac aatcgatcat
    12061 tcagtcacaa atacagaaca gcttgaacga caaaaccccg ccataaaaac aaagctcaaa
    12121 ctgaaaaagc ttaaggatca ggtgatcgtc attaccggcg cttcaagcgg aatcggactt
    12181 gtcacggcac gaatggcagc tgaaaaaggc gcaaaggtcg tggcagcagc gcgaaatgaa
    12241 gacgcgctga aggagctcac tgatgaactt aaggaaaaag ggcacgacgc catatgggta
    12301 aaggcggatg tcggaaaaga agaggacgtc aaccgcatcg cagaaaccgc gatcagcaca
    12361 ttcggccgct ttgacacatg ggtcaacaat gcggccgtct cgactttcgg acatgccatg
    12421 gacgtcaccg tcgaagacat gaagcgcatg ttcgacacaa atttctgggg acctgtttac
    12481 ggaacaagag cggctgtcaa acactacacc ggcagaggtg tgccgggcgc actcattaat
    12541 gtaggaagcc tgttcggaga caggggaacg gtcattcaat ccacatatgc atctgccaaa
    12601 tttgcgcttc acggctggac ggaaagcatc cgaatggagc tcgaaaagga acaggcgccc
    12661 gtctcggtaa cgctcatcca cccgggcaga attgacacac cttataacga gcatgcgcac
    12721 agctacctcg acaaacagcc ggctcattac cgctccatga tctatccacc ggaagcagtc
    12781 gccgaagcga tcctgtttgc cgccgaacac cctaagcgcg acatgtacat cggctcacag
    12841 gccaaagcca tcgccatgct gggcgcgctt ttccctcgtc tgaccgacag actgatggaa
    12901 aaaatcatgt atcacagcca gcatgccgaa aaaccgtcca aaccgcgaga agaaagtgct
    12961 ctttatgatg cgggctgcgg tatgcatgac agaggcacaa ataaaggatg gatgaggtca
    13021 agaagctact acacgaatgc gacgaagcgc cccattgtat ctgcggctgt tgttgcagga
    13081 ctagtggctt gggctgccgc caaacgatgc agataatctc tgaccatgat agaaaaaccc
    13141 atgctgttcc agcgaaccat gggtttttta gctgttaatc gataaaagcc ttgttcatac
    13201 gctgcagcag ctcgccgaac atctcttttt cctgtgttga ccattctttc agcatctgtt
    13261 cataacgttc aaggcgcttt tgctgatcgg cttttaatag ttgtttgccg agttttgtaa
    13321 tggtaaacag gct
//
