LOCUS       gnlProkkaBHDKMDBO_62   15585 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BHDKMDBO_62.
ACCESSION   gnlProkkaBHDKMDBO_62
VERSION     gnlProkkaBHDKMDBO_62
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 16:26:35
            Original ID  :: gnl|Prokka|BHDKMDBO_62
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 1868
            Orig. end    :: 17453
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15585
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:11134]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11134
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..15585
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15585
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             complement(1624..1962)
                     /locus_tag="ctg61_4"
                     /transl_table=11
                     /translation="MRPSSVIVNVAVDQGGVVETVNRVTSHDKPVYETHGVLHYAVANI
                     PVAVARTSTIALTNVTIPYIEALAGVGFKQAIENDEGLRQGVTTYQVHITSQPVPEGLN
                     RSCTAIDE"
     CDS             complement(1937..2074)
                     /locus_tag="ctg61_5"
                     /transl_table=11
                     /translation="MLIGIPKEIKNNENRVALTPAGVQSLLAKGHVVLIETNASKFCYC
                     "
     CDS             complement(2507..3652)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1244:amidohydrolase (Score: 359.1; E-value: 4e-109)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg61_6"
                     /transl_table=11
                     /translation="MTEVFYDHLAKTRHQIHQHPEVSGEEHETTVFLKAYLKNLGVEPL
                     NYPLKTGLIAEIGSGHPIIALRADIDALPIKEKTGLPYASDNGAMHACGHDFHQTSLLG
                     AAQLLKEREAELKGTVRLIFQLAEENFQGAYQVIEAGGIEGVSAIIGYHNNPHLKPGQI
                     GLRSGAILAGVEQFRVDVKGVSSHAARPDLGVDTVLVTTTIINNLQQIVARTVSPFESA
                     VLSVTHIEVGNTWNVLPAAGFFEGTIRTFEPKVREDVIARFEKVVQATADQFGAQVDIT
                     WGNSPYVTYNDQTLTPLIFENSKAFAEVIETLPSTGGEDFAAYQKEIPGVFAFVGTNGE
                     EDAPGWHHDDFLVKDEALPVAVNYYVENALFLLDYFKEQDD"
     CDS             complement(3888..4607)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1154:Pseudouridine synthase (Score: 201.2; E-value:
                     2.1e-61)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg61_7"
                     /transl_table=11
                     /translation="MRLDKLLGQSGYGSRNQVKKLIRSRQVYVDGVLADRDNLNVDASL
                     QTIMVSGKELEHAPEVYYLMNKPSGVVSARKDKEHQTVIDLIRPEDQREGLYPVGRLDR
                     DTEGLVLITNNGPLGFAMLHPRYHVAKTYYVEVNDILGPDAPAFFESGVVFEDGTVCQS
                     AQLEVLSSASDKSCARVTISEGKFHQVKKMFLAYGVKVTYLKRISFGEFKLDEGMAVGS
                     YRTLTEAEKTILRTYLG"
     CDS             complement(4687..5373)
                     /locus_tag="ctg61_8"
                     /transl_table=11
                     /translation="MLEDKNFAERLNILRAGVLGANDGIISIAGVVIGVASATSNIWFI
                     LISALSAIFAGAFSMAGGEYVSVSTQKDTEEAAVAKEQALLDRSPESARESLYQTFLSQ
                     GDCETEAEVKVNQAFSKNPIKVLVEEKYGVDMEEITNPWHAAVSSFLSFSVGSLPPTLA
                     ILLFPDPYRIPITAVVVALTLILTGYVSAKLGKAPVKQAMLRNLAVGLLTMLVTYVVGQ
                     VFHVNV"
     CDS             complement(5464..6234)
                     /locus_tag="ctg61_9"
                     /transl_table=11
                     /translation="MLLTEFDANRQAIINPEALHEPLEGFPKIAVSCFSRLTFQRMLEM
                     FPHELIYEISMANVAIPIYKLVIDDNELAIFNAPVGASACVGILEDIFALGADKLVLFG
                     TCGVLDEDIKETSIIIPSHALRDEGTSFHYVEASDEIAVNVGVLDHFRSYLNERQISHK
                     EGKVWTTDGIYRETNGKLKARKSAGAICVDMECSAVAALAKFRGVDICHFFYAADHLSE
                     GNWDARNLMNHMDLDEKDKIALLALEFACDWIKP"
     CDS             complement(6313..6807)
                     /locus_tag="ctg61_10"
                     /transl_table=11
                     /translation="MMKFKLVNNKVTDEREKALNNKVGAECFYIMIAGTLACLVYSSFF
                     NKGVITSNYLAFPLFIAWIWSIYRSERLSVNTFGGSGMTVLGCLLVTALITLMIMSANY
                     QFNHNVYHNNPLDPRYLMAWPLTYILYIPFVFFMNWALTALGRYERRRLEKQLDDLENE
                     E"
     CDS             complement(6821..7018)
                     /locus_tag="ctg61_11"
                     /transl_table=11
                     /translation="MAKNLRLKAARAEHDMTQGDLAEAVGATRQTIGLIEAGKYNPSLA
                     LCIAICKTLDRTLDQLFWEI"
     CDS             complement(7197..8180)
                     /locus_tag="ctg61_12"
                     /transl_table=11
                     /translation="MAKPIRVLLYYKYVPIENAEQFAADHLAFCKSIGLKGRILVADEG
                     INGTVSGDYETTQKYMDYVHSLPGMEDLWFKIDEEEEQAFKKMFVRYKKEIVHLGLEDN
                     NFDSDINPLETTGAYLSPKEFKDALLDEDTVVLDTRNDYEYDLGHFRGAIRPDIRNFRE
                     LPQWVRDHKEEFMDKRVVVYCTGGVRCEKFSGWLVREGYKDVGQLHGGIVTYGKDPEVQ
                     GELWDGKLYVFDERIAVDVNRVDPIVVGKDWFDGTPCERYVNCGNPFCNRRILTSEENE
                     DKYLRGCSHECRVHPRNRYVSENDLSQEEVVERLAAIGEGLDVTPA"
     CDS             complement(8369..9091)
                     /locus_tag="ctg61_13"
                     /transl_table=11
                     /translation="MTQFFYLLRWNYLRQKNLFILFTLAQVLLSVSLLFGYPLVIGKMD
                     TTTAYYLASGSVLMGVISIGCTISSPVIANAKSEGHVDYIRALPIPRILISLADLCIWL
                     IAILPGVFFTFLLGCLRFSVQLNLSILSVFVMLLICLTMISLGFSIAYIFSQNIVTLMS
                     QLILMIGLMFSPIMYPAGRLPDWLDQLYFLLPFVPSANLLRASFYRHGTVSLVDIGVLI
                     FWIFLTQLLILGTLQKEL"
     CDS             complement(9093..10004)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 171; E-value:
                     5.6e-52)"
                     /gene_kind="transport"
                     /locus_tag="ctg61_14"
                     /transl_table=11
                     /translation="MTFETLTIENLTKSFDKQHFANNHIFLELEAAKITALIGHNGAGK
                     STLLKQMIGFIKPDQGDVHYGDISFIHNRKQARTMMSYMSQQYAPLEKLTVEQNLEMIG
                     RMRGLSTSELQKEIEHLLADLEIVEYRDKKGKNLSGGLKRLTSFAMALIGSADIMLLDE
                     PTNDVDPVRREKQWRLLQKLAYKGHTIIIVTHNLLEVEKYADNFALFNHGKLLKSGPVH
                     QMSYKNHYQISFNFVSKEFLSLFEHFTMVNGCVCQMEIEESELTRILIQVKEGIEKGLI
                     SNLSVKMKTLSISDIYKEELVN"
     CDS             complement(10001..11134)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Pantocin_Microcin_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ThiF"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg61_15"
                     /sec_met_domain="Pantocin_Microcin_RRE (E-value: 3.1e-13,
                     bitscore: 40.1, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="ThiF (E-value: 2.7e-48, bitscore: 154.7,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSHCPRIKEIYPIYKLHDNLFRVGSQIGITTEISDEDDKMWSLV
                     NILDGRTINDVVDIMLTKYPDLTEQDIIGAIELLDKEGVIEEGATINCIKERYHSNIYY
                     FSRYLNSFKDSIDIQKRLNETTVLLLGLGGGGSNILTLLSGLGPKKIKIVDFDIIEKSN
                     LGRQFLYKEEDVGALKTQIAHQEVSKMNSDIEVETHNLRITCVNDLLPLLDNVDIVICV
                     IDEPQYDIQRIVNKAVVTKNIPCVFGASQVSRRRVYSVVPHQTGCFDCLNIHYTKIDSL
                     FLEQFRGIRTVTKKIPTIAYGPAMFQLTSAIVDEAVRLITKYAEPMSLNRQYEINYENG
                     ASFTHKPWGHYPDECPTCGNGKEENWEIFSQYGEIKL"
     CDS             11467..12177
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 57.6; E-value: 2.2e-17)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg61_16"
                     /transl_table=11
                     /translation="MLKVAICDDSDRDASQLEHYLLSYDKFPLETKLYTNPQKLLNQRT
                     PDIHCVFLDINMPGINGIDVAQKIRKFNPFIPIIFVTSYRDYMEQVFEVQTFDYIVKPI
                     EPQKLMKVLDRILRFLDIGQALFTFSFGKHNYSVPSSDIVFFEKDKRSVFIYTKTGTYK
                     SLLKTKEILEKLPNYFIQIHASYILNPKYIKDFDSKTVTILLNGTEEHLLPISRKFQFS
                     FKEKYYSYLSERHF"
     CDS             12177..13472
                     /locus_tag="ctg61_17"
                     /transl_table=11
                     /translation="MLVGLRIISILYDLFLASMLFYRPLSKINMKKKPLVALFFILIFH
                     GELVFLFSESRIFLVSNLLLNILEYYLIGLNFDYPIRQSSFWILLQTSLSLLAGAVLNQ
                     GIQLILPLGELSKNLEAISLYLGISFFLSTGITLILRKLLLSHQRLRIATSKGNWLYQF
                     IVPLLSIFFAFTISAIQGGVFGADYLSIISLSSLIVLTLSSLYFNLYLARQQQQYYQNQ
                     LEKEQLQFQVREIQQSQEEYQRLQSLRHDLKNKHLTLLSLLEKNPEEAKDYLYSLTDSI
                     VGEQTFYSKNQTINFLLNQKLHHLKDEIEMEIDCFVPQELSIQPDILAVILGNCLDNSI
                     AACLRLPNKERNLSLNIRYFQQNLFINIRNNFDEKEKSTRKSRQKDGWGLRNIDALVQE
                     YQGNIKHFIKDGQYQIEILLPIKIGTIPTKEF"
     CDS             complement(13638..14339)
                     /locus_tag="ctg61_18"
                     /transl_table=11
                     /translation="MKKILVKNQVEGGKVAFELLKESLTAGAQTLGLATGSSPIALYQE
                     MVESDVDFSELYSVNLDEYVGLSPEHEQSYHAFMKAQLFDAKPFKESFLPDGMAEDLEK
                     AAKDYDDVLAQHVIDLQILGIGSNGHIGFNEPGTPFDSQTHVVDLTDSTIEANSRFFAS
                     RDQVPTKAISMGIASIMAAKKIILFAYGDKKADAIFKMVKGPVTEEVPASVLQHHPDVT
                     LILDEAAAAKL"
     CDS             14489..15532
                     /locus_tag="ctg61_19"
                     /transl_table=11
                     /translation="MNTNDFDFELPEELIAQTPLEQRDASKLLVIDPVTREMTDTHFDH
                     IIDQLNPGDALVMNNTRVLPARLYGEKTDTHGHVEFLLLKNTQGDQWEVLAKPAKRLKV
                     GAKVSFGDGRLTATITKELDHGGRIVEFSYDGIFLEVLESLGEMPLPPYIHEKLEDRDR
                     YQTVYAKENGSAAAPTAGLHFTPELLQKIEAKGVKLVYLTLHVGLGTFRPVSVDNVDEH
                     EMHSEFYTLSQEAADTLNSVKAAGGRIVAVGTTSIRTLETIGNKYDGQLQADSGWTNIF
                     IKPGYQFTVVDAFSTNFHLPKSTLVMLVSAFAGREFVLEAYKHAVQERYRFFSFGDAMF
                     VTRPSEK"
ORIGIN
        1 cgtgtttcaa ggttatagct accatcacca gttaggtaat taaagacaat gcggaaatca
       61 tctagtgaga tataagtgaa ttgaagtcca ccattaacat cacccaccgc aaagacacct
      121 ggaacacttg tttccaaatg cttattaacc tggataccac cacgttcagt caaggcaata
      181 tcagtatttt ccaagtgaag gggttcaata ttaggcttgc gtcctgtcgc atagaggagc
      241 gcatcaaaac ggaagtcccc tttgtcagta acaacgacaa cttcatcacc gtcattctta
      301 acttcagatg ttctaacacc ttgctcaaag acaatgccgt cctcttccat gtattgcttg
      361 gccaacttag caatagatgg ctctacacgt ggcaagaagc tagtcgctgc atccaagaca
      421 gtcacttgac tacccaaacg gttataaagg ccagcaaatt caagaccgat attaccacca
      481 cctaggatac ccaagcgttt tggcaaagct tcaagagttt gaatgccagt tgagtcgtaa
      541 acatgcttag ttgttgtcaa gccaggaata ggcaagatat tagacacagc gcctgtattg
      601 ataacaatag tctcagctgt aagctcttga cggtcatcac cagccaccac ttcaatgacc
      661 ttatttgaca caaaatgtgc ttctgcatca atgacatcaa cgccattgtc tgccaacatt
      721 ttataattct tagcattaag acgactagtc actgcaccac gttctttcat ggtgtcgtca
      781 aatgaccagc ccttctcagc cgcaacaatc atagtcttag ttgggataca cgcaatatta
      841 atgcaagtac caccatacat cgctttactg cgctcgatga cagcaacttt cttaccagcc
      901 gcattcatct tagcagccaa cgttttaccg gctttaccga aaccgataac aatcaaatca
      961 tagttcaaca tttctgtatc ctcctattca tcggcattat atcatttaat ctttcagact
     1021 gcacatatat gaactggaaa ataaaaaggc tacagttttt gatataaccg atttcatatc
     1081 ttatgttaat ggagatatat gcaccctttg aaaattatgt ggtaaaaaac taaaaaaaaa
     1141 agaagaacac aacatttttt ctaaagagtt gtccacagtt tctccaaaaa gcttcgaaag
     1201 aaatatttgc tcctatcttc gagcaagtat cacatggtaa agcatttcaa gcagcgctgc
     1261 cacacctact gtaattagaa gcttggtcaa tgatacatcg atttttacac caaaataaaa
     1321 gacgacaaga taagagaaaa taatttctgt gagaacacga atatgattgg ctatggtaaa
     1381 acctctttat gagcgcattt tttaagtaaa aacagaaaga gtcataggtg ctcattacta
     1441 atgttgagat gtctgctcat tatagcataa aacaatacct agattagaaa aaataagcag
     1501 atttaagctt tatagacact tgacgatcaa ctaccaaaca cacgattacc tcttatccta
     1561 actaaaacac accaattcat ggcgcgactt atctttcatt ctgatagaat tataaactta
     1621 tagtcactcg tcaatagctg tacagcttct attcaatcct tctggaacag gttggctagt
     1681 aatgtgaact tgataagtcg ttacaccttg gcgaaggcct tcgtcatttt caatagcctg
     1741 tttaaagcct actcctgcaa gagcttcgat ataaggaatg gtaacattgg taagagcaat
     1801 ggttgatgta cgtgctactg caactggaat attagcaaca gcatagtgaa ggacaccgtg
     1861 tgtttcataa acaggcttat cgtgacttgt cacacgattc acagtctcaa caaccccacc
     1921 ttggtcaacg gcaacgttaa caataacaga acttggacgc atttgtttcg attaatacta
     1981 cgtgtccctt agccaaaaga ctttggacac ctgcaggtgt aagagctaca cggttttcgt
     2041 tgtttttgat ttcttttgga ataccaatta acatattttc tcctcattcg gaggtcataa
     2101 ggtaaaggat tgtgcaaatc gcttaaccac ttcctatcta tctttctgta atgatagcgc
     2161 tttcatttta actaaaatca agagaaaaaa atctccgcta ttttaagacc ttagaatcat
     2221 actcccctaa ctatctaaac aattcacaaa agaacccaac caatcggctg ggctcttaag
     2281 ttgtaaacta aatgatcaaa agagtatttt ttcttatgca catcctcctt tttattttca
     2341 aaagcagcac caatttaaaa tccttaagct tcatggaaaa ctcttaataa aataatcaaa
     2401 gagtccttgg tctgctaatt gcttatgacc caagagaaac tctggatgat tggacttctt
     2461 tccgcaacag ttttttcatt actagtgatt ccaattaagg aaatagtcag tcgtcttgct
     2521 ccttaaaata atcaaggagg aaaagagcgt tttccacata gtaattaacg gctacaggca
     2581 aggcttcatc tttcacaagg aaatcatcat gatgccagcc tggggcatcc tcctcaccat
     2641 tagtgccgac aaaggcaaag actcctggta tttccttttg ataagccgca aagtcttctc
     2701 cgcctgttga tggcagcgtt tcaatcactt ctgcgaaggc tttagaattt tcaaagatga
     2761 ggggtgtgag agtctggtca ttgtaggtca cgtaaggtga attaccccaa gtaatgtcaa
     2821 cttgagcacc aaactgatcc gctgtcgcct gaacaacttt ttcaaagcga gcaatgacat
     2881 cttcccgaac cttaggctcg aaagtccgaa tcgttccttc gaagaagccg gctgctggaa
     2941 gaacattcca ggtatttcca acttcgatat gagtaactga caatacagct gactcaaagg
     3001 gagataccgt ccgagccaca atttgctgta aattattaat gatagtcgta gtaaccaaga
     3061 ccgtatccac acccaaatca ggacgggctg catgggacga aacacccttg acatcaaccc
     3121 taaactgctc cacgcctgcc aaaatagcac ctgaacgaag gccaatctga ccaggtttca
     3181 agtgaggatt attgtgataa ccgatgatag ctgacacacc ctcaataccg cccgcttcaa
     3241 tgacctgata ggccccttgg aaattttcct cagccagttg aaaaattaat cgaacagtcc
     3301 ccttaagctc tgcttctctt tcttttaaaa gctgagcagc accaagcaga gaggtctggt
     3361 gaaaatcatg accacaagca tgcatggcac cattgtcgct agcataagga agacctgtct
     3421 tttccttaat cggtagggca tcaatatcag cacgcaaggc aataatagga tgacctgacc
     3481 caatctcagc gatgagtcct gtcttcaagg gataatttaa aggctcaaca cctagatttt
     3541 tcaaataagc tttcaaaaag actgtcgtct catgctcctc cccagaaacc tctggatgtt
     3601 ggtgaatctg atgacgcgtc tttgctaaat gatcgtaaaa tacttctgtc ataatgaacc
     3661 tccctctctg atcagttttg gattgtcaat ctatttgtga aactctcaat cgaattgatt
     3721 tcatcatacc accagaagcg atacttgaga aataaaaaat atttatagta ttccataagt
     3781 atttcttata cctctaaaaa atactgtcat tataggtgtt atcgtattaa gactagcgat
     3841 aagatagtct tatcagctga ttgaaagttc ctatcgcacc ttagctacta acccaaataa
     3901 gtacgcaaga ttgttttttc cgcttcagtc aaggttcggt aggaacctac tgccatccct
     3961 tcatcaagtt taaactctcc gaaagagata cgcttgagat aggtcacctt gaccccataa
     4021 gccaaaaaca tcttttttac ttgatgaaac ttaccttctg aaatcgtgac tcgagcgcaa
     4081 cttttatcac ttgcagaact taaaacttcc agctgagctg attgacaaac agtcccatcc
     4141 tcaaagacca caccagactc aaaaaatgca ggtgcatcag gccccagaat atcattaacc
     4201 tcaacataat atgtcttagc cacatgatag cgtgggtgaa gcatggcaaa gcccaaggga
     4261 ccattattgg taatcaacac caaaccttcc gtatctctat ccaaacgtcc cacaggataa
     4321 aggccctctc gctgatcctc aggcctaatc aaatcaataa ctgtttggtg ttccttgtcc
     4381 tttctggctg acaccactcc tgacggctta ttcataaggt agtagacttc tggcgcatgc
     4441 tccagttctt taccagaaac catgatggtt tgaagactag catccacatt aagattatct
     4501 cgatccgcca ggacaccatc tacatatacc tgacgactac gaatgagctt cttgacctga
     4561 ttgcgagaac catagcccga ctgtcctaat aatttatcta aacgcatagc cctattgtac
     4621 catggataag tctggtctag tagacaaaaa aagcctacct aaaaggtaga ctcatactac
     4681 taacaattac acattcacat gaaagacttg cccaactaca taggtcacga gcatggtcaa
     4741 gagtcctact gccaagtttc gcaacatcgc ttgtttaaca ggtgctttcc caagtttagc
     4801 actaacatag ccagtcaaga ttaaggtcag tgcaaccaca accgctgtta taggaatacg
     4861 ataaggatct gggaaaagca ggatagctag cgttggaggc aaagatccca ctgaaaagga
     4921 cagaaaacta gatacggcag catgccatgg attggtgatt tcttccatat ccaccccata
     4981 tttttcctca actaagacct tgataggatt tttactgaag gcttgattga ccttaacttc
     5041 cgcttctgtt tcgcaatccc cttgactgag gaaggtttga tataaacttt ctctagctga
     5101 ctcaggagag cgatccaaaa gggcttgttc cttagcgaca gccgcttctt cggtatcttt
     5161 ttgcgttgac acactgacat attcaccacc tgccatcgaa aaggcaccgg caaaaatcgc
     5221 tgacaaggct gaaatcaaga taaaccagat attagatgtc gcactagcca caccgataac
     5281 cactcccgca atggaaatga tgccatcatt ggcacccaac acaccagctc tcaaaatatt
     5341 taaacgttct gcaaaattct tatcttccaa caattgttcg ctccttattt agaatcatta
     5401 taaaaaagta ttataatagt tatttagatt gattacaaat aataaatcta aaaagtagaa
     5461 tttttaaggt ttaatccagt cacacgcaaa ctccaaagct aataaagcta tcttatcctt
     5521 ttcatccaag tccatatgat tcatcaagtt acgggcgtcc caattacctt cagaaaggtg
     5581 gtccgcagca tagaagaagt ggcagatgtc aacacctcta aactttgcta aagctgcaac
     5641 agcagaacac tccatatcca cacaaatggc tcctgctgac tttctagctt tgagtttacc
     5701 attcgtctca cggtaaatgc catcagttgt ccaaaccttg ccttccttat gagaaatctg
     5761 acgttcattg agataggaac gaaaatggtc taaaacaccc acatttaccg caatctcatc
     5821 gctggcttcc acatagtgaa aactcgtccc ttcatctcta agggcatgac taggaataat
     5881 aatagaagtc tctttaatat cttcatcaag caccccacaa gtaccaaaaa gtacaagttt
     5941 atcagctccc aaggcaaaaa tatcctctaa aatacccaca caggcagagg cgcctacagg
     6001 tgcattaaaa atggccaact cattatcatc aataacaagc ttataaatcg gaatagccac
     6061 attcgccatg gatatttcat agataagttc atggggaaac atctcaagca ttcgttgaaa
     6121 ggtcaaacga gaaaaacagg atacagctat tttaggaaaa ccttcaagag gctcatgtaa
     6181 ggcctcggga tttataatcg cttgtctatt cgcatcaaat tcagttagta gcatacgtga
     6241 cctccttagt tttaggaccc attataacac aaaaaaatca gaccaaaaag aacggtctga
     6301 ttctatcact atttattctt cattctccaa atcgtccagc tgtttttcaa gacgtcttct
     6361 ctcatatctt cccagtgctg tgagagccca attcataaaa aagacaaagg gaatatacaa
     6421 aatataagta agtggccaag ccatgagata tctaggatcc aggggattat tatgatagac
     6481 attgtggtta aactgatagt tagctgacat tatcataaga gtgataagcg cagtcaccag
     6541 taaacaacct aagactgtca ttccggaacc cccaaatgtg ttaacactaa gtcgttcaga
     6601 tctataaata gaccaaatcc atgctataaa taatggaaag gccaagtaat tagaggtaat
     6661 aacccccttg ttaaagaagg aactatagac caagcacgca agcgtcccag caatcattat
     6721 gtaaaaacat tctgcaccaa ctttattatt tagagctttt tctcgttcat ctgtaacttt
     6781 attattaaca agcttaaatt tcatcatctt tacttccttc ctaaatctcc caaaacagtt
     6841 gatccaaagt cctgtccagt gttttgcaaa tggcaataca tagggctaga ctgggattgt
     6901 actttccagc ttcaatcaac cctatggttt gtcttgttgc acctaccgct tctgccaagt
     6961 caccctgggt catatcatgc tctgctcgag ctgcttttaa gcgtaaattc tttgccacat
     7021 gccccctcct tttcatctta tctgatatta tcgtcgacat tgattaggtt caccatctgt
     7081 tttcatctta attatacact atatatttct aattgcaata tatatgtgtc gtaattttag
     7141 aaataaattg caaaataaaa aaccgagatt gctctcagct tcttctctat ttaaacttag
     7201 gctggtgtta catccaagcc ctcaccaatt gccgcaaggc gttcaacaac ctcttcttgg
     7261 ctcaaatcat tttcagagac ataacggttg cgtgggtgaa cacggcattc gtgtgagcag
     7321 ccacggaggt atttgtcttc attttcctct gaagtaagga tacggcgatt acagaatggg
     7381 ttgccacagt tgacatagcg ttcacaaggt gtgccatcga accagtcctt accgacaacg
     7441 ataggatcta cacggttgac atcaacggca atacgctcgt caaagacata caacttacca
     7501 tcccaaagtt ccccttgaac ctctgggtct tttccgtaag tcacgatacc accatgcaat
     7561 tggccaacat ctttatagcc ttcacggacc aaccaacctg agaatttctc acagcggaca
     7621 ccaccagtac agtaaacaac cacgcgctta tccatgaact cttctttatg atcgcggacc
     7681 cattgtggca attcacggaa gttgcgaatg tcaggacgaa tggcaccacg gaagtgacca
     7741 aggtcatatt catagtcgtt acgtgtatca aggacaacag tatcctcatc caaaagagcg
     7801 tctttaaact ctttgggtga caagtaagca cctgtagttt caagtggatt gatgtcgcta
     7861 tcaaagttat tatcctctaa gccaaggtga acaatctcct tcttgtagcg aacaaacatc
     7921 ttcttgaaag cttgttcttc ttcctcatca atcttgaacc aaaggtcctc catccctgga
     7981 aggctatgaa cgtagtccat gtatttttga gtggtttcat agtctccaga aaccgttcca
     8041 ttaatcccct cgtcagcgac caagatacga ccttttagac cgattgactt acaaaaagcc
     8101 aagtggtcag ccgcaaattg ctcagcgttt tcgatgggaa cgtatttata ataaagcaat
     8161 actcgaatag gttttgccat tgtacttcct ctttctttat gaaatatcta tatttgttgt
     8221 ttgataataa aatcaactta actattatac cgctatcaaa gaggactagg caattgattt
     8281 gtttggagga gaattgtcac aaaagaaaaa ggctgagtac cagatgtcta aacctgagtt
     8341 tcgtaagatt gttttccata agatagtatt acaactcttt ctgtagtgtc cctaagataa
     8401 gcagttgtgt cagaaaaatc cagaaaataa gaactcctat atctacaagc gaaacagttc
     8461 catgtctata aaagctagct ctaagaagat tcgcagaagg gacaaatgga agtagaaaat
     8521 aaagttgatc taaccaatct ggaagacgac ctgccggata catgattggt gaaaacataa
     8581 gaccaatcat taaaataagc tgagacatta gcgtgacaat attttgggaa aatatataag
     8641 caattgaaaa tcctagacta atcattgtta ggcaaataag taacatcaca aaaacagaca
     8701 aaattgacaa atttaattgg acagaaaagc gaagacagcc taataaaaaa gtgaagaata
     8761 cacctggtaa aatagcaatt aaccatatac ataggtcagc taaagaaatt agaattctag
     8821 gaataggtaa agctcgaata tagtccacat gaccttctga cttggcattg gctataacag
     8881 gagatgaaat cgtacagcca atagaaataa ctcccattaa aactgatcca gaggcaagat
     8941 agtaagcagt tgttgtgtcc atcttaccaa ttaccaacgg atacccaaaa agaagtgaaa
     9001 cggacaaaag cacttgagct agtgtgaata gaatgaatag atttttttgt cgaagatagt
     9061 tccaacgaag taagtaaaaa aattgagtca tatcagttaa caagctcctc tttataaata
     9121 tcggaaatag ataatgtttt catcttaact gaaaggtttg aaataagccc tttttctata
     9181 ccttccttaa cttgaatgag tattcgggtt aattcacttt cttcaatttc catctgacaa
     9241 acacaaccat tgaccatcgt aaaatgttcg aatagactta aaaattcttt actaacaaaa
     9301 ttgaaagaaa tttgataatg atttttataa gacatttggt gtactggacc agattttaat
     9361 aatttaccat ggttaaaaag agcaaaatta tccgcatatt tttcaacttc tagtagattg
     9421 tgggtaacaa tgataatagt gtgtccttta taagccagtt tttgtaataa tcgccactgt
     9481 ttttcacgac gtacaggatc aacatcgttg gttggttcgt caagaagcat gatatcagca
     9541 gagccaatta atgccatggc aaaagatgta agccgtttta agcctcctga aagattcttc
     9601 ccttttttat cacggtattc tactatttcc agatctgcta gaaggtgctc aatttctttt
     9661 tggagttctg aggtacttaa ccctctcatt cttccaatca tctctaaatt ttgctcaaca
     9721 gttaactttt caagaggtgc atactgttgt gacatataac tcatcattgt tcgagcttgt
     9781 ttacggttat gtataaaaga aatatctccg tagtgaacat ctccctgatc aggcttaata
     9841 aaaccaatca tttgctttaa aagagttgat ttaccagcac cattatgtcc tataagagct
     9901 gtgatttttg cagcttctag ctctaagaag atatggttat tagcaaaatg ttgtttatca
     9961 aatgattttg ttaaattttc aatggtgagc gtttcaaaag tcataatttt atttctccgt
    10021 attgagaaaa gatttcccaa ttttcctcct taccgttacc acatgtagga cactcatcag
    10081 gataatgtcc ccaaggtttg tgtgtgaacg acgctccgtt ttcataatta atctcgtatt
    10141 ggcgattaag actcattggt tctgcatatt tagttattaa tcgaacagcc tcatcaacaa
    10201 tagcagatgt caattgaaac atagccggac cataagcaat tgtaggaatt ttcttagtaa
    10261 cagtacgaat accccgaaat tgttccaaga atagactatc aattttcgtg taatgaatgt
    10321 ttaaacaatc aaaacatcct gtttgatggg gtactacaga ataaacacgt ctgcgactaa
    10381 cttgacttgc accgaaaaca cacggaatat tttttgtaac tacagcttta tttacaatac
    10441 gctgaatatc atattgtggt tcatcaataa cacaaataac aatgtcaaca ttgtctaata
    10501 atggcaacaa gtcgtttaca catgttatac gtaaattatg agtttcaact tcgatatcag
    10561 aattcatttt tgacacttct tgatgggcaa tctgtgtttt aagagcccct acgtcttcct
    10621 ccttatataa aaattgccta cctagattac ttttttcaat gatatcaaag tccacaattt
    10681 ttattttttt aggtcctaga ccagatagca aagttagtat attggaccct cctccgccaa
    10741 gtcctaataa aagaactgtc gtttcattaa gtctcttttg aatatctata ctatctttaa
    10801 aactatttaa atagcgacta aaatagtaga tatttgaatg atatctttcc ttaatacaat
    10861 ttattgtagc accttcttca ataaccccct ccttatccaa tagttcaata gcacctatta
    10921 tatcttgttc cgtcaaatct ggatacttag ttaacataat atctacaacg tcattaatag
    10981 tccttccatc taaaatatta actaaactcc acattttatc gtcctcatca ctgatttcag
    11041 tagttatacc aatttgggag cctaccctaa acaaattatc gtgaagttta taaataggat
    11101 atatttcttt tattcttgga caatgggatt tcattttttc ctcactgttt ttcaaaaaga
    11161 aagatgaggt gattctataa tttcccctcg ccttattgta gtaattctat caaaaatttt
    11221 ccgtgataga atcgaaggta acatttgctt atatgtttat ttaacatttt taagcaatta
    11281 aataataccc cagctaattt cggtttgagc tacggcctta cgtacttgaa tgtttttcat
    11341 ttggaattct cctttcatct ttaataagaa tattgtatac taaacttaca tttttcttac
    11401 aattatgtca taattgacca ttttaacgtt ataactaaca tacagaaatg agtgaggagg
    11461 ttttcaatgt taaaagttgc tatttgtgat gactctgata gagatgctag ccaattagaa
    11521 cattatttac tttcttatga taaatttcct ctagaaacaa aactttatac aaatccacaa
    11581 aaactcttaa atcagcggac gccagacatc cactgtgtct ttttggatat caatatgcca
    11641 ggaatcaatg gaattgacgt agcacaaaag attagaaaat ttaatccttt cattcctatt
    11701 atttttgtga caagttatcg tgattatatg gaacaagtct tcgaagttca gacttttgac
    11761 tatatcgtaa aaccgataga acctcaaaag ttaatgaaag tattggatcg tattttgcgt
    11821 tttttggata taggccaagc actttttacc ttctcatttg gtaaacacaa ttattctgtc
    11881 ccttcgagcg atattgtatt ttttgagaaa gataaacgtt cagtatttat atacacaaag
    11941 acaggtacct acaagtctct actaaaaaca aaagagattt tggaaaaact ccctaattat
    12001 tttattcaaa ttcatgcttc ctatatttta aaccccaaat acatcaaaga ctttgattca
    12061 aaaacagtta ctattttact aaatgggact gaagaacacc tactcccaat tagtagaaag
    12121 tttcagtttt cttttaaaga aaagtattac agctatctaa gtgaaaggca tttttaatgt
    12181 tagtaggatt acgaataatc agtatcttgt acgatttatt tctagcaagt atgttatttt
    12241 atagaccatt gtctaaaatc aatatgaaaa agaagccttt agtagccctt tttttcatat
    12301 tgatttttca tggggaactc gtgttcctat tctctgaaag tcgtattttt ttggtcagta
    12361 atctccttct aaacatttta gaatactatc taatcggtct caattttgat tatcctattc
    12421 gccagtcttc cttttggatt cttttacaaa ctagtctaag tttgttagca ggagctgtcc
    12481 taaaccaagg aatccaacta attttacctt taggggaact atcaaaaaat ttagaagcta
    12541 ttagtttgta tctcggaata agtttcttct tatctacagg aataactctt atcttacgaa
    12601 agcttctcct atcccatcaa aggcttcgta ttgctacttc taagggaaac tggctttatc
    12661 agtttatcgt gcctctttta tctattttct ttgcttttac aatatctgcc attcaaggag
    12721 gggtatttgg agcagattac ctgtcaatca tttctctctc atctctcatt gtattaactc
    12781 tctcctctct ttattttaat ctgtaccttg ctcgtcaaca gcagcaatat taccaaaacc
    12841 aattggaaaa agaacaatta cagttccaag ttcgagaaat acaacaatct caagaagaat
    12901 atcaacgtct ccaaagcctt cggcatgact taaaaaataa acatttaact cttttatcgc
    12961 ttttagagaa aaatcctgaa gaggcaaaag attatcttta ttcattaaca gatagtatag
    13021 taggtgaaca aactttctac tctaaaaatc aaactattaa ttttttactt aatcaaaaac
    13081 tacatcattt aaaagatgag atagaaatgg aaattgattg ctttgtacca caagaattat
    13141 ctattcaacc agatatttta gctgttatat taggaaactg cctagacaat agtattgcag
    13201 cttgtctcag actaccaaat aaagaaagaa acttatcact taatatccga tactttcaac
    13261 aaaatctttt tatcaatatt agaaataatt ttgatgagaa agaaaaatct actcgtaaat
    13321 cccgtcaaaa agatggctgg gggttgcgaa atattgatgc tcttgttcaa gaatatcaag
    13381 gtaatatcaa acactttata aaagatggac aatatcaaat agagatttta ttaccaataa
    13441 aaatagggac tattccgact aaagaatttt aggtaattga tgaaaaatga gtaataatta
    13501 ggtaacgtaa atatttgaag tcaaaatcta tattatgttt attcattaat aaacaggttg
    13561 agtagcacta gctcaacctg tttttttcta taactttctg attacctaac tcgcatctgc
    13621 tcgactcatg ttttctccta caatttcgca gcagcagcct catctaagat aagagtcacg
    13681 tctggatgat gttgcaagac actagctggc acttcctctg tcactggccc cttgaccatc
    13741 ttgaaaatgg catctgcctt cttgtcacca taggcaaaca agataatctt cttagcagcc
    13801 ataatagaag caattcccat tgaaatagcc tttgtaggga cttggtcacg actggcaaag
    13861 aaacggctat ttgcttcaat ggtgctatcc gtcaagtcga ccacatgggt ttgactatca
    13921 aaaggcgtac ctggctcatt aaaaccaata tgcccattac ttccgattcc taagatttgc
    13981 agatcaatga catgttgtgc caagacgtca tcgtaatcct tagccgcctt ctccaaatct
    14041 tcagccatac cgtcaggtaa gaagctttcc ttaaatggct tggcatcaaa gagttgagcc
    14101 ttcataaagg catgatagct ctgctcatgc tctggtgata gtccgacgta ttcatccaaa
    14161 ttgacgctgt aaagttccga aaaatccacg tcactctcaa ccatctcttg gtaaagggcg
    14221 ataggggaac tacctgtcgc caatcccaat gtttgagcac ccgctgtaag gctctctttt
    14281 agaagttcaa aggcaacttt gcctccctca acttgattct taactaaaat ctttttcatt
    14341 ctattcacct caatattggt atataccatt ttctttatta tctctttttt aaccttcctg
    14401 tcaagcgttt tcacttgata agtttaatga ctgtcgccct atatcgtgct ataataaaaa
    14461 ggctgaaaat ttttaaacga ggaaacaaat gaatacaaac gattttgatt ttgaactacc
    14521 agaagaacta attgcccaaa ccccattgga acaacgtgac gcctctaaac tcttagtcat
    14581 tgatcctgta actagggaaa tgactgatac ccacttcgac cacatcattg atcagcttaa
    14641 ccctggagat gccttggtca tgaacaatac gcgcgtgctt cctgcccgcc tctacggtga
    14701 aaaaactgat acacacggcc atgtagaatt tctccttttg aaaaataccc aaggtgacca
    14761 atgggaagtt ttggccaaac cagccaaacg ccttaaagta ggtgctaaag tcagttttgg
    14821 tgatggtcgc ttgactgcca ctatcactaa ggaactggat cacggcggac gtatcgtaga
    14881 atttagctac gacggtatct tccttgaggt tttggaaagc ttaggcgaga tgccactgcc
    14941 accttatatc catgaaaaat tggaagaccg cgatcgttat caaacggtct atgccaagga
    15001 aaatggctct gccgctgctc caacagctgg actccatttc acacctgagt tacttcaaaa
    15061 aattgaagct aaaggcgtaa aattggtcta cctcaccctc cacgttggac taggaacctt
    15121 ccgacctgtt tctgtcgata atgtcgacga gcatgaaatg cactcagaat tttacaccct
    15181 cagccaagaa gcggccgata ccctcaatag tgtcaaagct gctggaggtc gcattgttgc
    15241 agtagggaca acctcaatcc gaacactgga aacaattgga aataaatatg atggccaact
    15301 ccaagccgac tcgggctgga ccaatatctt tatcaaacca ggttatcaat tcacagtcgt
    15361 agatgccttt tcaaccaact tccaccttcc aaagtcaacc ttggtgatgt tggtttcagc
    15421 ctttgctggt cgtgaattcg tcctagaggc ctacaaacac gccgtccaag aacgctaccg
    15481 cttcttcagt ttcggagatg ccatgttcgt aacacgacct tcggaaaaat aaatagtgat
    15541 gttgagactt ctcttacagg ggaagtctct cttactgcac atcac
//
