GCA_027947345.1 - 9 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

gnlProkkaFDAJCDNG_1 (original name was: gnl|Prokka|FDAJCDNG_1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1.1	T3PKS	1	25,081

gnlProkkaFDAJCDNG_3 (original name was: gnl|Prokka|FDAJCDNG_3)

Region	Type	From	To	Most similar known cluster		Similarity
Region 3.1	RiPP-like	1	6,433

gnlProkkaFDAJCDNG_14 (original name was: gnl|Prokka|FDAJCDNG_14)

Region	Type	From	To	Most similar known cluster		Similarity
Region 14.1	lanthipeptide-class-iv	1	12,231

gnlProkkaFDAJCDNG_42 (original name was: gnl|Prokka|FDAJCDNG_42)

Region	Type	From	To	Most similar known cluster		Similarity
Region 42.1	lanthipeptide-class-iv	1	10,111

gnlProkkaFDAJCDNG_49 (original name was: gnl|Prokka|FDAJCDNG_49)

Region	Type	From	To	Most similar known cluster		Similarity
Region 49.1	RiPP-like	1	8,437	ubericin K	Other	12%

gnlProkkaFDAJCDNG_57 (original name was: gnl|Prokka|FDAJCDNG_57)

Region	Type	From	To	Most similar known cluster		Similarity
Region 57.1	NRPS-like	1	6,636

gnlProkkaFDAJCDNG_59 (original name was: gnl|Prokka|FDAJCDNG_59)

Region	Type	From	To	Most similar known cluster		Similarity
Region 59.1	RaS-RiPP	1	4,931

gnlProkkaFDAJCDNG_67 (original name was: gnl|Prokka|FDAJCDNG_67)

Region	Type	From	To	Most similar known cluster		Similarity
Region 67.1	RaS-RiPP,lanthipeptide-class-iv	1	18,167

gnlProkkaFDAJCDNG_89 (original name was: gnl|Prokka|FDAJCDNG_89)

Region	Type	From	To	Most similar known cluster		Similarity
Region 86.1	RiPP-like	1	14,367

Region	Type	From	To	Most similar known cluster	Similarity
Region 1.1	T3PKS	1	25,081
Region 3.1	RiPP-like	1	6,433
Region 14.1	lanthipeptide-class-iv	1	12,231
Region 42.1	lanthipeptide-class-iv	1	10,111
Region 49.1	RiPP-like	1	8,437	ubericin K	Other	12%
Region 57.1	NRPS-like	1	6,636
Region 59.1	RaS-RiPP	1	4,931
Region 67.1	RaS-RiPP,lanthipeptide-class-iv	1	18,167
Region 86.1	RiPP-like	1	14,367

Compact view

gnlProkkaFDAJCDNG_1 - Region 1 - T3PKS

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Location: 1 - 25,081 nt. (total: 25,081 nt) Show pHMM detection rules used

Region on contig edge.

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

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core biosynthetic genes

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KnownClusterBlast

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
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Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaFDAJCDNG_3 - Region 1 - RiPP-like

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Location: 1 - 6,433 nt. (total: 6,433 nt) Show pHMM detection rules used

Region on contig edge.

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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resistance

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
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Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaFDAJCDNG_14 - Region 1 - lanthipeptide-class-iv

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Location: 1 - 12,231 nt. (total: 12,231 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-iv: (cds(LANC_like and Pkinase) and not micKC)

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core biosynthetic genes

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Lanthipeptides

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

Lanthipeptide predictions

Lanthipeptides - No core peptides found.

Lanthipeptides

Core peptide predictions

No core peptides found.

gnlProkkaFDAJCDNG_42 - Region 1 - lanthipeptide-class-iv

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Location: 1 - 10,111 nt. (total: 10,111 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-iv: (cds(LANC_like and Pkinase) and not micKC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

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resistance

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KnownClusterBlast

Lanthipeptides

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		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

Lanthipeptide predictions

Lanthipeptide(s) for ctg42_4

ctg42_6

Leader:

MSEEILMLQSMSVEEEINEVN

Core:

GQRFSTMSNYHCGGANFSLASNHYCRRK

Core with dehydrations:

GQRFDhaDhbMDhaNYHCysGGANFDhaLADhaNHYCysRRK

antiSMASH-DB 4.0 matches for ctg42_6

100.0% NZ_JADNKH010000035.1and 1 other:

NZ_OU540596.1 Lanthipeptides: JQ838_RS08065_lanthipeptide

Lanthipeptides: I2E19_RS11270_lanthipeptide

1

GQRFSTMSNYHCGGANFSLASNHYCRRK

28

GQRFSTMSNYHCGGANFSLASNHYCRRK

1

GQRFSTMSNYHCGGANFSLASNHYCRRK

28

42.9% NC_012470.1and 5 others:

NZ_CABY01000005.1 Lanthipeptides: SZBHS5_RS10335_lanthipeptideNZ_CP065058.1 Lanthipeptides: I2434_RS07250_lanthipeptideNZ_CP078012.1 Lanthipeptides: KV238_RS00510_lanthipeptideNZ_LS483328.1 Lanthipeptides: DQL47_RS07600_lanthipeptideNZ_LS483368.1 Lanthipeptides: DQM56_RS07295_lanthipeptide

Lanthipeptides: SZO_RS10195_lanthipeptide

1

GQRFSTMSNYHCGGANFSLASNHYC

25

G RFST S CG N+S S C

1

GMRFSTTSLSWCG--NWSAISAFGC

23

39.3% NZ_KB946328.1: Lanthipeptides: UC3_RS18350_lanthipeptide

1

GQRFSTMSNYHCGGANFSLASNHYC

25

G RFS++S CG N S S C

1

GARFSSLSGGSCG--NLSSVSIWDC

23

with 4 more sequence matches

35.7% NZ_MSKU01000037.1: Lanthipeptides: allorf_43371_43508_lanthipeptide

4

FSTMSNYHCGGANFSLASNHYC

25

ST+SN HC G S + YC

1

ISTISNEHCWGWP-SAVTTRYC

21

32.1% NZ_CP084108.1and 2 others:

NZ_CP102383.1 Lanthipeptides: NP781_RS20720_lanthipeptideNZ_JAASJR010000006.1 Lanthipeptides: HCH28_RS14710_lanthipeptide

Lanthipeptides: LCP48_RS21615_lanthipeptide

4

FSTMSNYHCGGANFSLASNHYCRR

27

+ST SN+ C G S+ S C +

2

YSTTSNFLCIGTP-SMMSQFTCSK

24

21.4% NZ_JACHIN010000025.1: Lassopeptides: allorf_47202_47381_lassopeptide

12

CGGANFSLASNHYCR

26

CGG ++ +YCR

3

CGGPHWEWIYPNYCR

17

14.3% NZ_LR134504.1and 1 other:

NZ_LR134504.1 Lanthipeptides: allorf_1623800_1623958_lanthipeptide

Lanthipeptides: allorf_1623800_1623958_lanthipeptide

1

GQRFSTMSNYHC

12

G RF T + Y C

1

GSRFETTAQYSC

12

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

ctg42_6 - Class III

Cleavage pHMM score: 1.30

RODEO score: 0

Monoisotopic mass: 3101.4 Da

Molecular weight: 3103.4 Da

Number of bridges: 2

Alternative weights: (assuming N unmodified Ser/Thr residues); 3121.4 Da N = 1; 3139.5 Da N = 2; 3157.5 Da N = 3

gnlProkkaFDAJCDNG_49 - Region 1 - RiPP-like

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Location: 1 - 8,437 nt. (total: 8,437 nt) Show pHMM detection rules used

Region on contig edge.

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

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core biosynthetic genes

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
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Similar known gene clusters from MIBiG 3.1

gnlProkkaFDAJCDNG_57 - Region 1 - NRPS-like

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Location: 1 - 6,636 nt. (total: 6,636 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

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core biosynthetic genes

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NRPS/PKS domains

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		NT	AA		NT	AA

Detailed domain annotation

Selected features only

Show module domains

Similar known gene clusters from MIBiG 3.1

No matches found.

NRPS/PKS substrates

NRPS/PKS substrate predictions

ctg57_1

Search NORINE for peptide: strict or relaxed

AMP-binding (6..388): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVTSCALIYK
Nearest Stachelhaus code(s):: Ala DVTNFALIYK (62% 8Å match)
Stachelhaus code match:: 80% (moderate)

gnlProkkaFDAJCDNG_59 - Region 1 - RaS-RiPP

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Location: 1 - 4,931 nt. (total: 4,931 nt) Show pHMM detection rules used

Region on contig edge.

RaS-RiPP: (PF04055 and TIGR01716)

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core biosynthetic genes

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
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Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaFDAJCDNG_67 - Region 1 - RaS-RiPP,lanthipeptide-class-iv

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Location: 1 - 18,167 nt. (total: 18,167 nt) Show pHMM detection rules used

Region on contig edge.

RaS-RiPP: (PF04055 and TIGR01716)
lanthipeptide-class-iv: (cds(LANC_like and Pkinase) and not micKC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

KnownClusterBlast

Lanthipeptides

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

Lanthipeptide predictions

Lanthipeptides - No core peptides found.

Lanthipeptides

Core peptide predictions

No core peptides found.

gnlProkkaFDAJCDNG_89 - Region 1 - RiPP-like

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Location: 1 - 14,367 nt. (total: 14,367 nt) Show pHMM detection rules used

Region on contig edge.

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

KnownClusterBlast

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.