LOCUS       c00016_gnlPro..        12880 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PBDJBLMN_16.
ACCESSION   c00016_gnlPro..
VERSION     c00016_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 18:30:55
            Original ID  :: gnl|Prokka|PBDJBLMN_16
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12880
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..753)
                     /locus_tag="ctg16_1"
                     /transl_table=11
                     /translation="MKIDQLQTPCYVIDEKKMRENLEILKKVQEDTGCKILLAQKAFSG
                     FALYPMIGKYLAGTTASGLFEARLGYEEMGKENHVFSPAYRTEDIEELDRICDHIIFNS
                     TAQLKKFKEVCTGASLGLRINPECSTQGDHAIYDPCAPGSRLGVTRENFDGECLKWIDG
                     LHFHTLCEQNADDLEKTLQAVEEKFGEFLSEVSWLNMGGGHHITREDYDVKLLEKCIQH
                     MKETYDLDIYLEPGEAVALNAGYLVTEVM"
     protocluster    1..12880
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[742:2880]"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      743..2880
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
     cand_cluster    1..12880
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /kind="single"
                     /product="Putrescine2spermidine"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12880
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Putrescine2spermidine"
                     /region_number="1"
                     /rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /tool="gutsmash"
     CDS             complement(743..2023)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Sacchrp_dh_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Sacchrp_dh_NADP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_2"
                     /sec_met_domain="Sacchrp_dh_C (E-value: 2e-43, bitscore:
                     141.1, seeds: 375, tool: rule-based-clusters)"
                     /sec_met_domain="Sacchrp_dh_NADP (E-value: 2.1e-35,
                     bitscore: 113.6, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRLLVIGCGGVASVAIRKCCQNSDVFTEIMIASRTKEKCDALKE
                     KIESTTKTKIETAKIDADNAAEVAELIRAYKPDAVLNVALPYQDLTIMDACLEAGADYI
                     DTANYEAEDTEDPTWRAIYEKRCKEKGFTAYFDYSWQWAYDEKFKKAGLTALLGTGFDP
                     GVTSVFSAYALKHYFDEIHTIDILDCNGGDHGYPFATNFNPEINLREVSANGSYWEDGH
                     WVETEPMEFKSVYDFPEVGKKDMYLLHHEEIESLAKNIPGVQRIRFFMTFGQSYLTHMK
                     CLENVGMLSTAPVEFNGQEIVPIQFLKALLPDPASLGPRTVGKTNIGCIFTGVKDGKEK
                     SIYIYNVCDHQECYKEVESQAISYTTGVPAMIGSMMVVTGQWKKPGVFNVEEFDPDPYM
                     EALNKWGLPWKVCEDPELVKVWKANED"
     CDS             complement(2020..2880)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synth"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synt_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_3"
                     /sec_met_domain="Spermine_synth (E-value: 4.4e-53,
                     bitscore: 171.2, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Spermine_synt_N (E-value: 2.4e-15,
                     bitscore: 48.0, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELWYSEFHTGNVKLSVRINRQLFSGESEFQRIDVFESEEFGRFV
                     ALDGEIVFSDKDEFIYDEMVTHVPMTVHPNVKNVLIIGGGDGGVARELIHYPQIESIDV
                     VESDKMFVDVCAEMFPDIAQGLKDERVNIYYEDGLRFLRNKKARYDLIINDSTDPLGHT
                     EGLFTKEFYGSCYTALRDDGIMVYQHGSPFYDEDEVECRKMHRKVFRSFPVSRVYQAHI
                     PTCPSGYWLFGFASKKYHPLEDFRPERFDNLNIETWYYTTNLHRGAFMLPKYVEDLLEE
                     EENSL"
     CDS             complement(2883..4340)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_7_arginine"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_4"
                     /sec_met_domain="OKR_DC_1_C (E-value: 1.3e-13, bitscore:
                     43.2, seeds: 113, tool: rule-based-clusters)"
                     /sec_met_domain="OKR_DC_1_7_arginine (E-value: 2.9e-126,
                     bitscore: 413.0, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDYERQQHAPIYEALERFRKKRVVPFDVPGHKRGRGNPELAQLLG
                     EKCVGLDVNSMKPLDNLCHPVSVIREAEELAADAFGAAHAFLMVGGTTSAVQSMILSVC
                     KAGDKIILPRNVHKSAINALVLCGAIPVYVNPEVNAQLGISLGMEVSQVEKAMDENPDA
                     VAVLVNNPTYYGICSDLRTIVKKAHARGMKVLADEAHGTHLYFGRNLPVSGMAAGADMA
                     AVSMHKSGGSLTQSSLLLLNKSMNAEKVRQIINLTQTTSASYLLLSSLDISRRNLALRG
                     EESFEKVAGMAQYAREEINEIGGYYAYGMDLINGTSVFDFDVTKLSIYTLGNGLAGIEV
                     YDLLRDEYDIQIEFGDICNILAYISIGDRLQDIERLVGALADIERLYKKDSTGMLSGEY
                     IAPAVVASPQQAFYAEKESLPMEQAAGRISGEFVMCYPPGIPILAPGEMVTQEIVEYIL
                     YARDKGCSMQGMEDPKVEHLQVLKGGI"
     CDS             5628..7313
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FTHFS"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_5"
                     /sec_met_domain="FTHFS (E-value: 2.3e-275, bitscore: 905.7,
                     seeds: 408, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGFKSDIEIAQECEMLPITQIAEKAGIDDKYLEQYGKYKAKIDYN
                     LLKESDKKDGKLILVTAINPTPAGEGKTTTTVGLADGMQRLGKSVMVALREPSLGPVFG
                     VKGGAAGGGYAQVVPMEDINLHFTGDFHAIGAANNLLAAMIDNHIFQGNALNIDPRKIT
                     WRRCVDMNDRQLRNVVDGLGGKTNGMPREDGYDITVASEIMAVLCLASDIKDLKERLSK
                     IIIGYTYGKVSEQKPVTAGDLHAEGAMTALLKDALKPNLVQTLEHVPAIVHGGPFANIA
                     HGCNSVTATKMAMKLADYAITEAGFGADLGAEKFLDIKCRMAGLKPSAVVIVATVRALK
                     YNGGVAKADLNNENLEALEKGIPNLLKHVSNIKNVYKLPCVVAINAFPTDTKAELDFVE
                     AKCKELGVNVALSEVWAKGGEGGIKLAEEVIRLVEEPNDFSYAYELEGSIEDKLNQIVQ
                     KVYGGKKVVLTANAQKQAKQLEALGFGNCPICVAKTQYSLTDDQTKLGAPTDFEVTVRN
                     LKISAGAGFIVALTGEIMTMPGLPKVPAAERIDVDETGKITGLF"
     CDS             complement(7422..8846)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lyase_1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FumaraseC_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_6"
                     /sec_met_domain="Lyase_1 (E-value: 1.2e-94, bitscore:
                     308.9, seeds: 17, tool: rule-based-clusters)"
                     /sec_met_domain="FumaraseC_C (E-value: 4.6e-22, bitscore:
                     70.1, seeds: 737, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKTDYRVERDSIGVKDIPEDVYYGVQSLRAAENFHITGLNMHPE
                     IINSLAYIKKAAAITNCEVGLLEKKKAQAIVQACDEIVSGKFHNEFIVDPVQGGAGTSL
                     NMNANEVIANRAIEILGGKKGDYTIINPNDDVNCGQSTNDVIPTAGKMTSLRLLQNLKK
                     QLLRLYDALNEKATEFDHIIKMGRTQMQDAVPIRLGQEFKAYSVAIMRDIHRMDKAMDE
                     MRTLNMGGTAIGTGINADEGYLRRIVPNLTEISGMDFIQAFDLIDSTQNLDPFVAVSGA
                     VKACAVTLSKMSNDLRLMSSGPRTGFGEINLPAKQNGSSIMPGKVNPVIPEVVNQVAFN
                     IIGNDVTITMAAEAGQLELNAFEPIIFYCMFQSIDTLGYAVQTLVDNCIVGITANEERC
                     RYLVENSVGIITAISPHLGYQKAADIAKKAIKTGESVRSLILKEKLMDEDELNRILDPI
                     HMTEPGISGKDYLIKK"
     CDS             8962..9897
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     58; E-value: 2.3e-18)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg16_7"
                     /sec_met_domain="LysR_substrate (E-value: 1.7e-33,
                     bitscore: 107.5, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 1.9e-18, bitscore: 58.0,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFQGMEYIYEVYKEKSFSKAAAALFISQPSLSANVKRVENRIGYP
                     IFDRSTKPLQLTEVGKHYIQAVEKVMDIENNLENYLLDLGNLKTGTLNVGGSNFFSSWI
                     LPPLIADFSQKFPHVQISLVEESTAKLSQFLQAGKLDLVIDNCILDNQIFERYIYQKEQ
                     LLLAVPKNYSVNTRLQKYQIPIEEIRNGQFRSSHIPSVPLNKFENEPFIILRSDNDTGK
                     RALTICQENHFSPSVVFRLDQQMTAYNIACLGMGITFIGDLLLSRVPTNSELVFYKLPG
                     QSSKRTVFFYWKKGRYISRAMEEFLKLPFS"
     CDS             complement(10009..11466)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FGGY_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FGGY_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_8"
                     /sec_met_domain="FGGY_C (E-value: 3.5e-38, bitscore: 123.0,
                     seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="FGGY_N (E-value: 2.2e-80, bitscore: 261.4,
                     seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYYIGIDLGTSAVKLLLMEESGKICNIVSREYPLFFPHPGWSEQK
                     PEDWFAQSMEGMKELTKDIDRAQVAGIGFGGQMHGLVTLDKDDNVIRPAILWNDGRTGE
                     ETEYLNTVIGKDKLSQYTANIAFAGFTAPKILWMQKNEPENFKKVVKIMLPKDYLAYRL
                     SGSFCTDVSDASGMLLLDVKNRCWSKEMLEICGITEEQLPKLYESWEVVGTLKPEIAKE
                     LGFSENVKVVAGAGDNAAAAVGTGTVGDGQCNISLGTSGTVFISSKNFGVDENNALHSF
                     CHADGSYHLMGCMLSAASCNKWWAEEILQTKDFAAEQAPIQKLGENHVFFLPYLMGERS
                     PHNNPDARGVFFGMSMDSTRADMTQAVLEGVAFGLRDSLEVARNLGIKIERTKICGGGA
                     KSPLWKKIIANVMNLKVDVLENEEGPSMGGAMLAAVGCGAYPDVETIGKKFAKVVDTVE
                     PDPELVAKYEERYQKFRTLYPAMKPLF"
ORIGIN
        1 cataacctct gtcaccagat atccggcatt cagggcaaca gcctccccgg gctccagata
       61 aatatccaga tcataggttt ccttcatatg ctgaatacat ttttccagga gctttacatc
      121 ataatcctct ctggtaatat gatgtccgcc gcccatattc agccaggaaa cctcagacag
      181 aaattctcca aacttctcct ctaccgcctg caaggttttc tccagatcat ccgcattctg
      241 ttcgcagagc gtatgaaaat gcagtccgtc gatccatttc agacattccc cgtcaaagtt
      301 ctctctggta acccccagcc tggaacccgg cgcacaggga tcatagatcg catgatcccc
      361 ctgagtggag cattccggat taatacggag tcccagactg gctccggtac acacttcttt
      421 aaatttcttc agctgtgctg tggaattaaa gataatatgg tcacagatcc gatccagttc
      481 ctctatatct tctgtacggt aagcagggga aaaaacatga ttctctttcc ccatctcttc
      541 atatccaagc cttgcctcaa acagaccgct ggcagtggta cctgccagat attttccgat
      601 catgggatac agagcaaagc cggaaaacgc tttctgcgcc agaaggatct tacacccggt
      661 atcctcctgg acttttttca aaatctccag attctcccgc atcttcttct catcaatcac
      721 atagcaggga gtttgcagtt gatcaatctt cattggcttt ccagaccttt accagttcag
      781 gatcttcgca gactttccat ggaagtcccc atttgttcag tgcttccata tatggatccg
      841 gatcaaattc ttccacatta aatacacccg gcttcttcca ctgtccggtc actaccatca
      901 tggaaccgat catagccgga acacctgttg tataggagat tgcctgggat tccacctctt
      961 tatagcattc ctgatgatca catacattat aaatataaat acttttctct tttccgtcct
     1021 taacacctgt gaaaatacag ccgatatttg ttttacccac tgttctcgga cccagagatg
     1081 caggatccgg cagaagagct ttcaaaaact gaatcggcac gatctcctgt ccattaaatt
     1141 ccacaggtgc ggtggaaagc attcctacat tttccagaca tttcatatgt gtcagatagc
     1201 tctgtccgaa tgtcataaag aaacggatcc tctgtactcc cggaatattt tttgccagtg
     1261 attcaatctc ttcatgatga agaagataca tatccttctt tcctacctca gggaaatcgt
     1321 agacagattt aaattccata ggctctgttt ctacccaatg tccgtcttcc cagtaggaac
     1381 catttgcgga aacctctcga agattgatct ccgggttaaa gtttgtggca aaaggatatc
     1441 catgatcacc gccgttacag tccagaatat caatggtatg gatttcatca aaataatgct
     1501 tcagggcata ggcactgaat acactggtaa cacccggatc aaaaccggtt cccagaagag
     1561 cagtcagtcc tgctttctta aatttctcat cataagccca ctgccaggaa taatcgaaat
     1621 atgcagtaaa gcctttttct ttacatctct tttcgtagat tgcacgccat gtgggatctt
     1681 ctgtatcctc tgcttcataa ttggcagtat caatataatc cgcaccggct tccagacatg
     1741 catccatgat ggtaagatcc tgatatggaa gtgccacatt caggacagca tccggcttat
     1801 aggctctaat caattctgcg acctctgctg cattatccgc atctatcttt gctgtctcaa
     1861 tttttgtctt cgttgtactt tcaatcttct ctttgagtgc atcgcatttt tcctttgtcc
     1921 tgcttgcgat cataatctct gtaaaaacat cgctgttctg acagcatttg cgaattgcca
     1981 ctgaagctac cccaccacat ccgattacca ataatctgct cataaactgt tttcctcctc
     2041 ttccagtaaa tcttctacat attttggaag cataaatgct cctctgtgaa ggtttgttgt
     2101 ataataccat gtttctatat taagattatc aaacctctcc ggcctgaaat cttccagtgg
     2161 atgatatttc tttgatgcaa atccaaaaag ccagtatccc gagggacagg tagggatatg
     2221 tgcctgataa accctgctca ccggaaatga ccggaaaacc tttctgtgca tctttctgca
     2281 ttccacctca tcctcatcat aaaaaggact tccatgctga taaaccatga ttccgtcatc
     2341 tctgagagcc gtataacagc ttccgtagaa ttcctttgta aaaagtccct ctgtatgtcc
     2401 cagcggatct gtggaatcat tgatgatcag gtcatatctg gcctttttat tccgcaggaa
     2461 ccgaaggccg tcttcataat aaatgttgac tctctcatcc ttcagtccct gggcaatatc
     2521 cggaaacatc tccgcacata catccacaaa cattttatcg gattccacca catcaatgct
     2581 ctcaatctgt ggataatgga tcagttctct ggcaactcca ccgtcaccgc cgccgatgat
     2641 cagaacattt tttacattgg gatgtactgt cattggcaca tgcgtaacca tctcatcata
     2701 aataaattca tctttatcag agaatacgat ctcaccgtcc agagccacaa atcttccaaa
     2761 ttcttcagac tcaaacacat cgattctctg aaattcactt tcccctgaaa ataactgtcg
     2821 gttaatccgg acagaaagct ttacatttcc tgtatggaac tcggaatacc ataattccat
     2881 gatcagatac cccctttcag gacctgaaga tgttctacct tcggatcctc cattccctgc
     2941 atggaacagc ctttgtctct tgcataaaga atgtattcta caatttcctg tgtcaccatt
     3001 tctccaggag caagaatcgg gattcccgga ggataacaca taacaaattc accgctgatc
     3061 ctgcctgccg cctgttccat gggcagagat tctttctccg cataaaatgc ctgctgtgga
     3121 gacgccacca ctgcaggtgc gatatattcc ccggaaagca tacctgtact gtccttctta
     3181 tacagacgtt caatatcagc caatgcccct accagtctct caatatcctg aagcctgtct
     3241 ccgatggaaa tgtaagccag aatattacag atatctccaa actcgatctg aatatcatat
     3301 tcatctctga gaagatcata aacttcaata cctgccagcc catttcccag tgtataaatg
     3361 gagagttttg taacatcaaa atcaaaaaca ctggttccat tgatcagatc catgccatat
     3421 gcataataac cgccgatctc attgatctcc tctctggcat actgcgccat ccctgcaacc
     3481 ttttcaaagg attcctctcc cctaagtgcc agatttcttc tggagatatc cagactggac
     3541 aacagaagat aagaagcgct tgtggtctga gtcagattga tgatctggcg cactttctct
     3601 gcattcatac tcttattcaa aagcagcagc gaactctgtg tcagacttcc gccggatttg
     3661 tgcatggaaa ctgccgccat gtcagcacct gccgccattc cggatacagg aaggtttctg
     3721 ccgaaataaa gatgggttcc atgagcctca tctgccagca ccttcattcc tcttgcatga
     3781 gccttcttta cgatagtccg cagatccgaa cagattccat aataggtagg gttatttaca
     3841 agaactgcca ccgcatccgg attctcatcc atagccttct ccacctggct gacttccatg
     3901 ccaagggaaa tgcccagctg cgcattcacc tccgggttta cataaaccgg aattgcaccg
     3961 cacagtacca gggcattgat ggcactttta tgtacatttc gcggcagaat gatcttatcc
     4021 cctgccttgc agacagacag gatcatgctc tgcactgcag atgtggttcc tcctaccata
     4081 aggaatgcat gcgctgcgcc aaaagcatct gctgcaagct cctccgcttc tctgatcacc
     4141 gaaaccggat ggcagagatt gtccagcggc ttcatagaat taacatccag ccccacacat
     4201 ttctctccca gcaactgtgc aagctctgga tttcctcttc ctcttttatg tcccggcaca
     4261 tcaaagggaa cgactctctt ctttcggaaa cgttccagtg cttcatatat gggcgcatgc
     4321 tgttgtcttt cataatccat ttgacatgtt cctcttttcc tgtcgtcatg taccggcaaa
     4381 tacagttcta tcattcagca attgtatact gcctcaaacc ggcacaatga ttcaattatt
     4441 tctctatata ttcaagtcga acgcatgtga gacacatcct cgcaaagcgt ttatctccaa
     4501 ccatatcctt tatatttgct atatctgcac aaaaaagaag cagataagtt cattcaccat
     4561 ctgcttctct catgatctat agaatttctc aggctctgtc tctttatata ctgaccggat
     4621 ttcccgtata aatccgtctg tatcctgtgc ctgttcccgt attctgaaat attcatgact
     4681 gctgtcgtct tcaatcgctg gcaaatatat gctatgctct tattgaccgt ttcacaagat
     4741 gatgtgtgct tacgcactga ttattataaa gtaatcaact tataaaattt gagcttctaa
     4801 ctcaatcaat aatgtggtgt ctcccacccg gcaactgccc cgcctgtccg tatggcttaa
     4861 cattcagaaa ctgtctctga atgtgagcaa atatttgcat gaaaacgata gtgtcttttc
     4921 atactaaaga tgagaataac atatcttctg aactgttgtc aattccattt tccatatttt
     4981 gcactagagc gtgtctgaaa aaggctttct gcaagatgtg cgtcacaatt tgtgggatat
     5041 tttgcccgga tgagggcgcc gtagcgggct acggcaactg aattcgggtg aaatatcccg
     5101 caaagtgggg gcgtacagat tgcgggaatg atttttcaga cacgctctag ctttacccgc
     5161 tttttatatt ttcttcattt atcagggaaa actgtgttta ttttttaaca atttctttcc
     5221 ttgagaaaac gtattttctt tcatgaccag ggattacgat tctcttctct tatcaatttg
     5281 cacaactttt atccagttta ctcacatttt ttgacgtttc aacaaaattt tcttgacatt
     5341 tttttctcaa aatgatatat tgtattcatc aattgaaaga accttcgagt actgacggaa
     5401 agagtggagt gcaaaccacg tggagtcgga ggtttgtggg agccgaccgt ctgggcagta
     5461 tttgaaatat tcagatactg gccttttttt ataactttca gggcagaaat caggaatacc
     5521 aggcagaccg gccaatactt ctttcaatta ataattgttg ctgatcgcgg agtgaacagc
     5581 aacagaagtt tttcatgtta tgcggaaacg aaaggagaaa aacaattatg ggattcaaat
     5641 cagacattga aattgcacag gaatgcgaga tgcttccaat tactcagatc gcagagaaag
     5701 caggtattga cgacaaatat ctggagcagt acggaaaata caaagcaaaa atcgactaca
     5761 atcttctgaa agaaagtgat aagaaggatg gaaaattaat cctcgttaca gctatcaacc
     5821 caactccagc aggagaaggt aaaactacta ctactgtagg tcttgcagat ggtatgcaga
     5881 gacttggcaa gagtgttatg gtagctcttc gtgagccatc cttaggaccg gtattcggtg
     5941 taaaaggtgg tgcagcaggc ggcggatatg cacaggttgt tcctatggaa gatattaacc
     6001 ttcacttcac aggtgacttc catgccattg gcgcagctaa caacttactg gcagctatga
     6061 tcgataacca tatcttccag ggcaatgcat taaacatcga cccacgtaag atcacatgga
     6121 gaagatgtgt agatatgaac gaccgtcagc ttcgtaacgt agtagatggt cttggcggaa
     6181 agacaaacgg tatgcctcgt gaagacggat acgacatcac agttgcatct gaaatcatgg
     6241 cagttctctg tcttgcaagc gacatcaaag acctgaaaga aagattatcc aagatcatca
     6301 tcggatatac atacggaaaa gtttccgagc agaaacctgt aacagcaggt gaccttcacg
     6361 cagaaggcgc tatgacagcc ctgttaaaag atgctctgaa accaaacctt gtacagactc
     6421 tggaacacgt tcctgcaatc gtacatggcg gaccattcgc aaacatcgct catggatgta
     6481 actctgtaac agctacaaag atggctatga agcttgctga ttatgcaatc acagaagctg
     6541 gtttcggtgc tgaccttggt gctgagaaat tccttgatat caaatgccgt atggctggtt
     6601 taaaaccaag cgcagttgta atcgtagcta cagtacgtgc cctgaaatac aacggcggcg
     6661 ttgctaaagc tgaccttaac aatgaaaacc tggaagctct tgaaaaaggt atcccgaacc
     6721 tgttaaaaca cgtttccaac atcaaaaacg tatacaaact tccatgtgtt gttgctatca
     6781 acgcattccc tacagataca aaagcagagc ttgactttgt agaagctaaa tgtaaagaac
     6841 tgggcgttaa cgttgctctt tctgaagtat gggcaaaagg cggcgaaggc ggaatcaaac
     6901 ttgcagaaga agttatccgt cttgttgaag aaccaaacga cttctcctat gcatatgaac
     6961 tggaaggttc tatcgaagac aaactgaacc agatcgttca gaaagtatat ggcggtaaga
     7021 aagtagttct gacagctaac gctcagaaac aggcgaaaca gttagaagct cttggattcg
     7081 gcaactgccc gatctgtgta gctaagactc agtacagctt aacagatgac cagaccaaac
     7141 tgggtgctcc tactgacttt gaagttacag tacgtaacct gaagatttcc gctggtgcag
     7201 gattcatcgt agctcttaca ggcgagatca tgacaatgcc aggtcttcct aaagttccgg
     7261 ctgctgagag aatcgacgta gacgagacag gtaagatcac aggtctgttc taatccggtt
     7321 gaaatcaatc gaataattca aaaatataaa aatcatattt atatatgata tgtgtccaga
     7381 cgattttaca ggcgggaaga ttttcccgcc tgtttttttc tttatttttt tataagataa
     7441 tcttttccgg aaataccagg ttccgtcata tggatcggat ccagaatgcg attaagttca
     7501 tcctcgtcca taagcttttc tttcagaatc agacttctta cagattcgcc tgtcttaatt
     7561 gccttttttg caatatccgc agccttctga tatccaagat gggggctgat tgcagtgata
     7621 atacctacac tgttttctac cagataacgg catctttctt catttgccgt aattcctaca
     7681 atacaattat ccaccaatgt ctggactgca tagccaagag tatcgataga ctggaacatg
     7741 caatagaaaa taatcggctc aaacgcattt aattccagct gaccagcctc tgcagccatg
     7801 gtaatggtaa catcattacc aataatatta aaagcaacct gattcactac ttcaggaata
     7861 accggattaa ctttacctgg cataatagag gaaccattct gttttgccgg aagattaatc
     7921 tccccaaaac cagtacgtgg accggaggac atcagacgga gatcatttga cattttggaa
     7981 agagttaccg cacatgcttt cacagcaccg gaaacggcta caaatggatc cagattctga
     8041 gtggaatcaa tcagatcaaa agcctgtata aagtccattc ccgatatttc agtgagattt
     8101 ggaacaattc ttctcagata gccctcatct gcattaattc ctgttccaat agcagtacct
     8161 cccatattaa gagtccgcat ttcatccatt gctttatcca ttctgtggat atcacgcatg
     8221 attgctaccg aatatgcctt aaattcctgt cccagacgaa ttggtactgc atcctgcatc
     8281 tgtgtacgcc ccatttttat tatgtgatca aactctgtag ctttttcatt aagagcatca
     8341 tagaggcgaa gaagctgttt tttcagattc tgcaacaaac gaagagaagt cattttaccg
     8401 gcagtaggaa taacgtcatt ggtagactgt ccacaattca catcatcgtt aggatttata
     8461 attgtataat cgcccttttt tcctcccagt atctcaatcg cgcgatttgc aattacttca
     8521 ttggcattca tatttaaaga tgtgccagct cctccctgaa caggatccac aataaattca
     8581 ttatggaatt ttcctgaaac aatttcatca catgcctgga caatcgcctg tgcttttttc
     8641 ttctcaagaa gccccacctc acaattggtt atcgctgctg ctttttttat gtatgcaaga
     8701 ctgttaataa tttccggatg catattcagc cccgtaatgt ggaaattttc agccgcacgt
     8761 aaggattgta ctccataata tacatcttcc ggaatatcct ttacaccaat agaatccctt
     8821 tctacacgat agtctgtttt tttcatagtt attcgccctc ccatgtattt gccctcatta
     8881 tatatctctg ctataatata atcaaataca tatattttta taaaatatat agtgtttaaa
     8941 ttatatatcg gaggagttta tatgtttcag ggaatggaat acatctatga ggtctacaag
     9001 gaaaaaagct tttccaaagc tgctgctgct cttttcattt cgcagccttc tttaagcgcc
     9061 aatgtaaaac gtgtggaaaa ccgtattggc tatcctattt ttgatcgaag taccaaacct
     9121 ttgcagttaa ctgaagttgg aaaacattat atacaggctg ttgaaaaagt catggatatt
     9181 gaaaataatc tcgaaaacta cctactggat ctgggaaatc tcaaaacagg aactcttaat
     9241 gtaggtggca gtaacttttt ttcttcgtgg attctgcctc cccttattgc tgatttttcc
     9301 caaaaattcc cccatgttca aatttctctt gtagaagaaa gtacagcaaa actatcccag
     9361 tttctccagg ccggaaagtt agatctggtg attgataact gtattctgga taaccagatt
     9421 tttgaacgtt atatctacca gaaagaacaa cttcttcttg cagttcccaa aaattactca
     9481 gtaaatacca gactgcagaa atatcagatt cctattgagg aaatccggaa cgggcagttc
     9541 cgttcttctc atattccttc tgttccatta aacaaattcg agaacgaacc atttattatt
     9601 cttcgttcag ataatgatac cggtaagcgt gcacttacca tttgtcagga aaatcacttt
     9661 tcgccttctg tagtatttcg cctagatcag cagatgactg cctataatat tgcatgtttg
     9721 ggaatgggta tcactttcat cggggatctt ctgctctcca gagttccaac aaattcagaa
     9781 cttgtttttt ataagctgcc cggtcagagc agtaaacgca ctgtgttttt ttactggaag
     9841 aaaggccgct atatcagcag agccatggaa gaattcctga agctgccctt ttcctgatat
     9901 gtcataatca aataggctat ggtgattggt catcatcaga tgtacgtcaa aatggggttg
     9961 ttgtgctaaa taagcacaac aaccccagta tgtcaggcag atattcgatt agaacaatgg
    10021 cttcatcgcc ggatacagag ttctgaactt ctgatatctc tcttcatatt ttgcaaccag
    10081 ttcaggatcc ggttctaccg tatcaacaac tttggcaaat ttcttaccga tggtttctac
    10141 atccgggtaa gcaccacagc ctactgctgc cagcatagct ccacccatgg acggtccttc
    10201 ttcgttctcc agaacatcaa ccttcaggtt cataacgttt gcaatgatct tcttccacag
    10261 tgggctctta gctccaccac cgcagatctt ggttctctca atcttgattc caaggtttct
    10321 tgcaacttcc agggaatcac gaagaccaaa ggcaacacct tccagaacag cctgtgtcat
    10381 gtctgctctt gtgctgtcca tggacattcc gaagaataca cctcttgcat caggattatt
    10441 atgaggtgaa cgttctccca tcaaatatgg aaggaagaat acatgattct ctcccagctt
    10501 ctgaattgga gcctgctctg ctgcgaaatc ctttgtctga agaatctcct ctgcccacca
    10561 tttgttacag gaagctgcgc tgagcatgca tcccatcaga tgatagcttc catctgcatg
    10621 acagaaagaa tgaagtgcgt tattttcgtc cacaccaaag tttttactgg aaataaacac
    10681 agttccggat gttccaagag aaatattaca ctgaccgtca ccaactgtac ctgttcctac
    10741 agcagctgcc gcattgtcac ctgcacctgc aacaactttt acattctcac tgaatccaag
    10801 ttctttcgca atctcaggtt tcagagttcc tactacttcc caactctcat acagtttcgg
    10861 aagctgctct tctgtgattc cacagatctc caacatttct tttgaccagc agcggttctt
    10921 cacatcaaga agaagcatac cggaagcatc agaaacatct gtacaaaaag aaccagacag
    10981 acgatatgcc agataatcct taggaagcat aatctttact accttcttaa agttctcagg
    11041 ctcatttttc tgcatccaga ggatcttcgg tgctgtgaag cctgcgaaag caatatttgc
    11101 tgtatactgt gaaagtttgt cttttccgat cactgtattc agatattctg tctcttcgcc
    11161 tgtacgtccg tcattccaga ggattgcagg acggatcaca ttatcatcct tgtcaagtgt
    11221 taccagacca tgcatctggc cgccaaaacc aattcctgct acctgcgctc tgtcgatatc
    11281 ctttgtcagc tctttcatgc cttccatact ctgcgcaaac cagtcttccg gtttctgctc
    11341 agaccagccc ggatgtggga agaataaagg atattctctg gatacgatgt tacagatttt
    11401 tcctgattct tccataagaa gaagttttac agcggaagta ccaagatcaa taccaatata
    11461 atacataagt gctctccttt tctatttcta atctaataca tcccagagca aagccccggg
    11521 atgcctttaa tatagtgtca gtttatttat tctgtattca gattcattca cttcacatga
    11581 acattaataa tccgttttac tgatttctca ttaaccccat ggattttctg tcgggtatct
    11641 tacgcctgcc ggctggttat atccaatctt cttaacatcc agtccaagga atttcactac
    11701 ctcatagaat gcttttccgt aatgtccaaa cataactgct ccatgatgcg gatagttgcc
    11761 ctcgatcagt acgtgacggt agaatcttcc catttctttg attgcgaaaa taccgatacc
    11821 accgaatgat cttgtaggta catccagtac ttcaccttct gcaacataag aaaccagctc
    11881 gccctcggaa ttgcactgta aacgatagaa tgtaatgtca gatgcagcga tatcaccttc
    11941 aagagttcct cttgtgaagt ctggttcaga tcctgccggc tcaagaagtc tgtgctggat
    12001 cagctgatat ttaacagctc tggaatcaca catcttgcat gcaggagtat ttccacaatg
    12061 gaatcccata aatgtatcag taagcttata atcgtatttt cctttaatat cttcatcata
    12121 gatatactgt ggaacagagt tgttgatatc aagcagtgta actgcatcat tggaaatgca
    12181 aagtccgatg tactcgctga gtgctccgta gatatcaacc tcacaggata ccggaattcc
    12241 tctggaaacc agacggctat ttacatagca aggttcaaat ccaaactgtg acgggaatgc
    12301 aggccaacat ttgtcagcaa atgcaacgta ttttcttgct cccttatgag cctctgccca
    12361 gtcaagaagt gtaagctcaa actgtgccat tttcacatta aggtcagcat aatatttgcc
    12421 ttcgcccatc tcttttgcca tatctgcaca aacttccggg atacgaggat cattttcatg
    12481 ctctttgaaa gaaacaagaa gatcaagctc tgagttctct tcaatctcaa cacccagctc
    12541 atagaggcct ttaataggtg cgttgcatgc gaagaagtcc tgtggacgtg gtccgaaagt
    12601 aatgatctta agattgctga caccgatgac tgcacgtgca accggtacga aatcagcgat
    12661 catctttgca atatcatctg ctgttccaac aggatattcc ggaatatatg ctttcagatg
    12721 acgcattttt aagttgtagg agcagttaag cataccacag taagcatcac ctctgccgtt
    12781 gatcatatca ccgtcacctt ctgctgctgc tacatacata caaggtccgt caaatctctc
    12841 tgcgatcaga gtttcaggag tttcaggtcc gaagtttcca
//
