LOCUS       c00217_gnlPro..        16925 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KOFLAKMA_217.
ACCESSION   c00217_gnlPro..
VERSION     c00217_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 13:20:05
            Original ID  :: gnl|Prokka|KOFLAKMA_217
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16925
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16925
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1139:6925]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1140..6925
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..16925
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16925
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             1140..2858
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg217_1"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.5e-49, bitscore:
                     157.9, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQISGNKLLVKALKEEGVEYLFGYPGACTIDISDELYKQDDVKI
                     ILPRHEQALVHEADAYARTTGKVGVCLVTSGPGATNLVTGLATANYDSVPLVCFTGQVA
                     RHLIGNDAFQEVDIVGITRSITKYGVTVRRREDLGRIIKEAFYIARTGRPGPVLIDLPK
                     DVMAELGSAEYPKNVNIRGYKPNTDVHIGQLKRAIKLLNKAKRPLFLAGGGVVISRAHE
                     IFREVVEKTKVPVVTTVMGKGSIPTDHPLYIGNLGMHGAYAANMAVSNCDVLFSIGTRF
                     NDRITGKLHEFAPHAQIIHIDIDTASISRNIQVDIPIVADAKEAITKMNEYVQECSTDK
                     WLNLIKNWKEEHPLKMRPNDLLSPMDILKEINEQFENSIIVTDVGQHQMLVSQYAEITE
                     GKQMIMSGGLGTMGYGLPGGIGAKIGNPDRPVIVISGDGGVQMNIQELATAVLEELPVI
                     LCIFNNEYLGMVRQWQKLFYGKRYAMTNLRAGALSRRTEGMEYPQYTPDFIKLAESYRA
                     KGIRVTKKEEIAAAFKEAKKNTKAPTVIEFIIDPEEMVYPMIKPGGTLEDMIMDC"
     CDS             2877..3563
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg217_2"
                     /sec_met_domain="ALS_ss_C (E-value: 7.6e-23, bitscore:
                     70.8, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKGMKKRWISLYVENQVGVLSKISGLFSGKSYNLDSLTVGTTED
                     PTVSRMTIATVSDDETFEQIKKQLNRMIEVIKVIDFTDVFVRMKEILYIKVFNCSREDK
                     AXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDFTDVFVRMKEILYIKVFNCSREDK
                     AELFQIAETFKAKVIDYGKDSLLLEFVQTATKNDAVVKLIKEEFHRIEVVRGGSVGIES
                     ISMMER"
     CDS             complement(3632..4888)
                     /locus_tag="ctg217_3"
                     /transl_table=11
                     /translation="VKSTERLIFHIDVNSAFLSWESARRVSQGLPDLREIPSCVGGDPK
                     KRTGIVVAKSIPAKKYGIQTGEPVAMALRKCPNLVIVPSDFELYDKCSRAFKAICASFA
                     PVMESFSIDEVFLDMTGTSLIYPDPVAAAHELKGKIHRELGFTVNVGISTNKLLAKMAS
                     DFQKPDRVHTLFPDEIPEKMWPLPIRNLLFLGKASEQKLLNQGIRTIGDLARERASNVQ
                     YWLGEKTGHQLWQYARGIDDSPVKAVPDEAKGFSVETTFNDDITSIEQVFPILLEQCDV
                     LATRMRRKDKKCNCISVTFRTLDFRNRSHQTKLENATDLTDEIYINATRLFKEFWKGQP
                     LRLIGVALTGLTDGTYEQMSLFEDTENKERHRKLDAAMDEIRMKFGNDKITRASIMNSN
                     ARIGRKAKAQMKNEKTEEP"
     CDS             5720..6364
                     /locus_tag="ctg217_4"
                     /transl_table=11
                     /translation="MAKAASKKGLKLLGISDHGPGTLASGTSSYFRSLPFYPRKRFGID
                     ILYGVELNILDSAGHTDLSDELLNNLDYAIISMHRQNYRSGSVSQNTEAYINAIKHPAV
                     KILGHCDDTHFPVDYETLARAALRENVIFEINEASLAPGGYRGDTRANAARILYLCQKY
                     QLPVILSSDSHGKEHVGDFTYAEEFVHQLMFPETLILNNQLPKLKVFLQTR"
     CDS             6629..6925
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg217_5"
                     /sec_met_domain="ALS_ss_C (E-value: 1e-23, bitscore: 73.6,
                     seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEVIKVIDFTDVFVRMKEILYIKVFNCSREDKAELFQIAETFQA
                     KVIDYGKDSLLLEFVQTATKNDAVVKLIKEEFHRIEVVRGGSVGIESISMMER"
     CDS             7357..7935
                     /locus_tag="ctg217_6"
                     /transl_table=11
                     /translation="MVELAMMIAIILLMSFTPLGYLRTPGLSITLLTIPVAVGAIILGP
                     KGGAVCGLAFGATSFYMAVTGSSAFAAALFNINPFGTFIVCIVARVLEGWITGLIFAAL
                     YKSPAKKFSYYVASLACPLLNTFFFMGFLCLFFYNTDYIQGIVSSLGVSNPVVFVAAFV
                     GVQGLIEAGFCFVVGSIVSKALSVALKRA"
     CDS             8297..9007
                     /locus_tag="ctg217_7"
                     /transl_table=11
                     /translation="MNYLESQNIGYNTGAALVPLVCQSCIYDLSYGDPKIRPTAKMGEE
                     ACRQAFAGTDARTGNIGAGTGATVGKLYGMKQSMKSGLGIAAVSVKNFQMAAIVVVNAL
                     GDIFSPQNGQKIAGLKTPDRSGFLDSVHELYRFMTPHDQFTGNTTIGAVITNGAFSKAE
                     LNKIASMTRCAYARCINPVATMADGDSIYAASIGDVSVDINMAGTLAAEVMAQAIQNAI
                     HTSRIQDEEFLKYV"
     CDS             complement(9420..10604)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1058:Major
                     facilitator family (Score: 78.7; E-value: 1.3e-24)"
                     /gene_kind="transport"
                     /locus_tag="ctg217_8"
                     /sec_met_domain="MFS_1 (E-value: 3.7e-25, bitscore: 78.7,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTNYNRTVQACFIGYVVQAIVNNFVPLLFLTFQGSYGISLQKIT
                     LLVTFNFGIQLLVDLASIGFVDRIGYRASMILAHAMAAAGLILLTVLPECLGDTFVGLI
                     IAVMIYAIGGGLLEVLVSPVVEACPTDNKEKAMSLLHSFYCWGHVGVVLLSTLFFRIFG
                     IANWKYMALVWALIPIANGILFTRVPIAPLLDEGEKGLTMGELFKKKIFWVLMLMMLCA
                     GASEQAVSQWASTLAEKSFGINKTIGDLAGPMAFAILMGSSRAFYGKFGDKINLERFMQ
                     YSAVLCMVSYLMIAFIPVPALGILGCAVCGLSVGIMWPGTFSMAAASVKRGGTALFALL
                     ALAGDVGCSSGPTYVGMISGALNDNLKLGIFAALIFPVLMILGIKMIGSLRKYD"
     CDS             complement(10944..11708)
                     /locus_tag="ctg217_9"
                     /transl_table=11
                     /translation="MLNQFSRTELLLGKEAMNKLENSRVAVFGIGGVGGYVCEALVRSG
                     VGTFDLIDDDKVCLTNLNRQIIATRKTVGQYKTEVMRDRILDINPKADVRIHNCFYLPE
                     NAADFDFSEYDYVVDAVDTVTAKIELIMRAKETGTPVISSMGAGNKLDASAFRVADIYK
                     TKVCPLAKVMRRELKKRGVKKLKVVYSEEQPIRPIEDMAISCRSHCICPPGAAHKCTER
                     RDIPGSVAFVPSVAGLIIAGEVIKDLTAEYRR"
     CDS             complement(12035..12742)
                     /locus_tag="ctg217_10"
                     /transl_table=11
                     /translation="VLEERIVMKTNEEEDSRHIFRGELALVIAVMINSLAVILMLYSGS
                     GISAISSVPYAFEKVFPVITLGTWTYIFQALLILSLMILRKKFVPAYLCSFLVGFAFSE
                     LLDVNEAWINILPKTIPLRVLYFVISYLLICIGIALSNRCGLPIIPTDLFPRELSEIIK
                     VKYSKIKVSFDVICLMITACMTGLILGHINGLGIGTVMAAFTMGKVIGLIGDEMDKHFR
                     FVNFTQHCSLHVQ"
     CDS             complement(12890..14308)
                     /locus_tag="ctg217_11"
                     /transl_table=11
                     /translation="MRKTKIICTMGPSTDKGDVMEQLVREGMDVARFNFSHGPHDEQRG
                     RIQKLRELRKKYDRPVAALLDTKGPEIRLGCFKDGKVSLEEGQIFTFTNKDIEGTNECV
                     SITYKELYKDVQPGGHILVDDGLVDLEVQDIAGKDIVCKVINAGVIGDKKGVNVPGANL
                     KMPFISKKDHDDLLFGIQEGFDFVAASFTRTANDIREVRKILKENGGEEIQIIAKIENQ
                     QGVDNIDEIIEAADGIMIARGDMGVEIPPEYVPVIQQKIIQKVYTAGKPVITATQMLDS
                     MISHPRPTRAEATDVANAIFQGTSATMLSGETAAGKYPVQALQMMSRIAEHMEQNIDYN
                     TIFKKTDRNENPDITNAIAHATCLTAIDLKASAILSVTKSGSTAHMMSKHRPGCLIGAC
                     TSSERVLRQLNLSWGVYPMLIKEEYSSEILCLRAIEAAQKHKLVKVGDTIVFAGGVPLG
                     IPGRTNLIRVCTVE"
     CDS             complement(14562..15092)
                     /locus_tag="ctg217_12"
                     /transl_table=11
                     /translation="MNYNRLETSLIDVIKEEQAKLGYMKEKISLYYPLSSLNHFFGNET
                     DAAGMMEILKDFPSYIEEKFGEVAVSHRGDRFCFTVSEKASEYVHNNMKENEFIKALIE
                     LVGRHGCTIEEIKELFHSYSDKIITEPMDNEEFDVMIRFDDGSDPYYYCFKDEGCHIIY
                     HRFLPEDYADFGF"
ORIGIN
        1 ctcctttcaa taatattcta ctctaatatc ttacaaaact caacatgtgc ttatatgatt
       61 ttataattta tatttaactg ttaataacct tccaaacagc tgtattattt attttttata
      121 tcagcaatat agaaatctgt caattacatt actgttcact ccgttctcag taacgtagcc
      181 aaaattcatt caggaacata aattttacag caattatcca aaacccggtt gacaatttcc
      241 tctctataaa tgtataatgt aacccaagaa aacatttgtc taccctattc ggacaatgaa
      301 tatccctata tcagccaaat gccatgacag ggaggagtac acaaccccgg gaagcacaga
      361 gagaaagcgg tcggtgcgag cttttgtgaa cgaattgtgg aagtagcccc cgagcagtga
      421 accaaaccgc atatcccgtc tgatccacaa gacctgaacg gacatgccaa gtaggcttca
      481 acgtcagttc cacgttacag gaacacagta tatcagtact gacaaagtgc agagccagac
      541 tctgaataca ggtggtaccg cggaaacatt ttcgccctgg gcaaacaagc ccagggcgtt
      601 ttttactata tttatatatc agggtcaaaa agtcgttcgt gcttgcttta atctgtcaca
      661 tcaaacccgc cgccccacac tcggcagaat cagcgcagcg ccattctgcc ccaccctgta
      721 ttggccaaca cacagctcgg aaatttattt gttttcgggt gcatttgcag gagtcgtagt
      781 aactcttagt gcctggaaat ctgcgttgtt cagaaaaatc tcactgtctg agccgcatct
      841 gcggcgagtt tgagattttt ctgaacggtt ttagcagatt ttcagacact tagagttcct
      901 agtacatcgt tttcgaaata actataccac tcacttgtct gcgaatccga ttgcacaggt
      961 ctaaaagcct cagcgtagcc cgctacgcct gcgtttttat accagcacac tcgaatccgc
     1021 atcctacgcg attggtatag ttatttacga aacgatgtac tagactccga aaccgcaccc
     1081 gaaaacaaat aaatttccga gcgtccccat ccacataccc aaaggaggtt tacccaaata
     1141 tgaaacaaat atccggcaac aaactcttag tcaaagcctt aaaagaagaa ggcgtagaat
     1201 acctcttcgg ctaccccgga gcctgtacca tcgacatcag tgacgaactc tacaaacagg
     1261 acgacgtcaa aatcatcctc ccccgtcacg aacaggccct tgtccacgaa gccgacgcct
     1321 acgccagaac caccggcaaa gtcggcgtat gtctggtaac cagcggcccc ggagcaacca
     1381 accttgtaac aggacttgca accgccaact atgacagcgt acctcttgta tgcttcaccg
     1441 gccaggtagc ccgccacctc atcggcaacg atgcatttca ggaagtagac atcgtaggaa
     1501 tcaccagaag catcaccaaa tacggcgtta ctgtccgcag acgtgaagac ctgggacgta
     1561 tcatcaaaga agccttctac attgcccgca ccggccgtcc gggacctgtc cttatcgacc
     1621 ttccaaagga cgtaatggca gaacttggta gcgctgagta tcctaaaaat gtaaacatcc
     1681 gcggatacaa gcccaacaca gatgtccata tcggccagct caaacgtgcc atcaaacttt
     1741 taaacaaggc aaaacgtcct ttattccttg caggcggcgg tgtagtaatc tcccgcgccc
     1801 acgaaatctt ccgggaagta gtagaaaaaa caaaagtacc ggttgtcaca accgtaatgg
     1861 gcaaaggttc cattcctact gaccatccgc tttatatcgg aaacctcggc atgcatggtg
     1921 cctatgcagc aaacatggca gtcagcaact gcgatgtgct gttctccatc ggaaccagat
     1981 tcaatgacag aatcaccgga aaacttcatg aatttgcacc acatgcccag attatccaca
     2041 ttgatattga tacagcatcc atttcccgaa acattcaggt ggatatcccc attgttgctg
     2101 atgcaaaaga ggctatcacc aaaatgaacg aatacgtcca ggaatgttca acggacaagt
     2161 ggcttaacct gatcaaaaac tggaaagaag agcatccgct taaaatgcgt ccaaatgatc
     2221 ttttaagtcc gatggatatc ctgaaagaga tcaacgaaca gtttgagaac agtattatcg
     2281 taacagatgt aggacagcat cagatgcttg tctcccagta tgcggaaatc acagagggca
     2341 aacagatgat catgtccggt ggtctgggaa caatgggcta tggtcttcca ggcggcatcg
     2401 gagccaaaat cggaaatccc gacagacctg tcatcgttat ctccggtgac ggcggtgtgc
     2461 agatgaacat tcaggagctt gcaactgcag ttctggaaga acttcctgtt atcctgtgca
     2521 tctttaacaa tgaatacctt ggaatggtac gccagtggca gaagcttttc tacggcaaac
     2581 gctatgctat gaccaatctg cgcgcaggag cactttcccg ccgcactgaa ggcatggaat
     2641 atccacagta cacaccagat ttcattaaac ttgcagaaag ctatcgcgca aagggaatcc
     2701 gcgttacaaa gaaagaagaa atcgcagccg ccttcaaaga agcaaagaaa aatacaaaag
     2761 cacctacagt aatcgaattt atcattgacc cagaagaaat ggtctacccg atgatcaaac
     2821 cgggcggaac tctggaagat atgatcatgg attgttaggc aggaggaaag attattatgg
     2881 ataaaggaat gaaaaaaaga tggatttctc tctatgttga gaaccaggta ggtgttctgt
     2941 ccaaaatctc cggacttttc tccggaaaaa gctacaatct ggacagtctt actgtaggaa
     3001 ctaccgagga ccccacagta tctcgaatga ctatcgcaac agtcagcgat gatgaaacct
     3061 ttgaacagat caaaaaacag ttaaaccgca tgatcgaggt tatcaaggta attgacttca
     3121 cagatgtatt tgtcagaatg aaagaaattc tctacatcaa ggttttcaac tgctccaggg
     3181 aagataaagc annnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3241 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnntt gacttcacag
     3301 atgtatttgt cagaatgaaa gaaattctct acatcaaggt tttcaactgc tccagggaag
     3361 ataaagcaga gctgtttcag attgcagaaa ccttcaaggc aaaagtcatt gactatggca
     3421 aagacagtct gcttctggaa tttgtccaga cagcaaccaa gaatgacgca gtagtgaaac
     3481 tgatcaagga agaatttcac agaattgaag tggtacgtgg aggaagtgta ggaatcgaat
     3541 ctatcagtat gatggaacga taaaactttt tctgaaattt ttataaaggg aggattgtcg
     3601 cattgttctt aatgctcagt cctctcttta cttacggttc ttccgtcttt tcgtttttca
     3661 tctgtgcttt cgcttttcgc ccaatccgtg cattgctgtt cataatactg gcacgggtga
     3721 tcttatcatt tccaaatttc atccggatct catccatagc tgcatccagc tttctgtggc
     3781 gttctttatt ttctgtatct tcaaacagag acatctgttc ataagtgcca tctgtaaggc
     3841 ctgtcagtgc cacaccaatc agacgcagcg gctgtccttt ccagaattct ttaaaaagtc
     3901 ttgtagcatt tatataaatt tcatctgtaa gatctgtagc attttccagc tttgtctggt
     3961 gtgaacggtt tctgaaatcc aaagtacgga aagtcacgga aatacagttg catttcttat
     4021 cttttctgcg cattctggtt gccagaacat cacactgctc caaaagtatg ggaaacacct
     4081 gctctatgga agtaatatca tcgttaaaag tagtttccac gctgaaacct tttgcctcat
     4141 caggcactgc ttttacaggg gaatcatcga tacctctggc atattgccat agctgatgtc
     4201 ccgttttttc cccaagccag tactgcacat tggatgctct ttctcttgcc agatcaccga
     4261 tggtacggat tccctgattc agaagcttct gctcggaagc ttttcccaga aacagcagat
     4321 tacggatagg aagaggccac attttctccg ggatttcatc cgggaacaga gtgtgtactc
     4381 tgtccggctt ttgaaaatct gatgccatct ttgccaaaag cttattggta gaaattccta
     4441 catttactgt aaatcccagc tctctgtgaa tcttgccttt cagctcatga gcagcagcta
     4501 cagggtcagg atagatcaga gaagtacctg tcatatccag aaatacctca tcaatggaaa
     4561 aagattccat cacaggtgca aaggaagcac agattgcttt aaatgcccgg gaacatttat
     4621 cgtataattc aaaatcactg ggaacgatca ccagattggg acatttccga agagccatgg
     4681 ctactggctc gccggtctgg atcccgtatt tttttgcagg gatagatttg gcaaccacga
     4741 tacctgtccg tttctttgga tctcctccta cacaggaagg aatttctctg agatccggca
     4801 gcccctggct cacccttctg gctgattccc aggaaagaaa tgcactgttg acatcaatat
     4861 gaaaaattaa tcgttccgta cttttcactg ttcttcctcc aatatatgaa ttgcgctctt
     4921 catatctgat gatttcattt taccctgatc tgctctccag ggtaagaacc tcgtttgtcc
     4981 aaaaaagtgt ctttatttac atcatcttgt ctgagctgtt actgtattta tatttgtttg
     5041 atttcactct gctatcagag ttttgaacaa caacgccgca cttgccatac ggcagtgcgg
     5101 cgtctgtatt tcgctaccgg tcacattgtt cccggtaact ttttttactt aattctgagg
     5161 attcatttcc tctcgatata tacttatcga ttagtcataa aggttgggag caatttcttc
     5221 gctgtccata tttgtggaat cataccagta tccagttcag cctccagcca ttcataagag
     5281 aattccggga atgtctgatg tttgaaattt ttccatgtta ctcctttctc atgaagtaac
     5341 tgtctacaca taagcaaaca gtgctatcgc tgtcattgat cagcaataag cccccgtgtt
     5401 ttcatatagt tccattatac cttctcattt tcccgaagtc aacataattt aacatgtatc
     5461 agccgtttat ttgtgttgct ttttatttga tttttgttgt atttcagttg tttttatttt
     5521 gtttcctcat tgacatttaa atcctcatct gtcatacttg aatataacga atgtaccatc
     5581 aaacagcagc tttgcatctt ccgtaaggct cttatcatat atagaaaccg ctctggaaag
     5641 gagacaaaca atgtatcttt ctgacatcca cacacattct atcgccagcg gtcacggaac
     5701 cacctgtacc atctctgaca tggcaaaagc agccagcaaa aaaggactga aactccttgg
     5761 gatttctgac cacggcccgg gaactctggc ttccggaact tcttcttatt tcagaagcct
     5821 tcctttttat cctagaaaaa gattcggcat agatattctt tacggagttg aactaaacat
     5881 cctggacagt gcaggacata cagatctgtc agatgaactg ctgaacaacc tggattacgc
     5941 tatcatcagt atgcatcggc agaactaccg ttcaggctct gtatctcaga atacagaagc
     6001 ttacatcaat gcaataaaac atcctgctgt aaaaatactc ggccactgcg acgatacaca
     6061 tttccctgta gattatgaaa cgctggcaag agcagcttta cgggaaaatg ttatttttga
     6121 aataaacgaa gcttccctcg cacccggagg atatcgggga gacacaagag ccaatgccgc
     6181 cagaatcctg tatctctgtc agaaatatca gcttcctgtt attttgtcca gcgacagcca
     6241 cggaaaagaa catgttggag atttcaccta tgccgaagaa ttcgttcacc agctcatgtt
     6301 tccggaaact cttatcctta acaaccagct tcccaaatta aaagttttcc ttcagacacg
     6361 ttaaaagaat gttcctcaaa gggacattct tttattttat gcattgtttt ttgcattgtg
     6421 ttattttgtt tgttttctat aatttcttgt caaaaaagac gacattttag tacattttaa
     6481 ttaacaaaac tcacttaacc atttacatat ctcgtgatag atcagtctta ctgtaggaac
     6541 caccgaggat cctacagtat cccgaatgac tatcgcaaca gtcagcgatg atgaaacctt
     6601 tgaacagatc aaaaaatagt taaaccgcat gatcgaggtt atcaaggtaa tcgacttcac
     6661 agatgtattt gtcagaatga aagaaattct ctacatcaag gttttcaact gctccaggga
     6721 agataaagca gaactgtttc agattgcaga aaccttccag gcaaaagtca ttgactacgg
     6781 caaagacagc ctgcttctgg aatttgtcca gacagccacc aagaatgatg cagttgttaa
     6841 actgatcaag gaagaattcc acagaattga agtggtccgc ggtggaagcg ttggaattga
     6901 atccatcagc atgatggaac gctaaatctc ataatcaata ttttttgcag gatatagaaa
     6961 cacctctata tcctgtattt attttcaaac atactataaa atattgcagt ttttaatcaa
     7021 atgtgttatt gtttacggga gcgttattcg aaagaaaatg catctgattt ccacatctga
     7081 cagtctggtg gataaagtca tccacttcac agtctggtta aatttgtgag gcgacctgta
     7141 aggcgtctac acaccggaaa cttttaccgg aagatatttc ttgtttcata tcttttgttc
     7201 tgatgtatat ttttcataac gcctgatccc catactctaa actgtctgaa aagcagggga
     7261 cgcattgcgc cgttttatca gaccaaaagg agaattcata tgaacacaac aactactact
     7321 acaacagctg ccacaaaaag aagcagcact ctttacatgg tagagctggc tatgatgatt
     7381 gccattattc tgctcatgtc ctttaccccg ctgggctacc ttcgtactcc cggcttatcc
     7441 atcactcttc tcaccatccc ggtagctgta ggagctatca tcctcggacc gaaaggtggt
     7501 gctgtatgcg gacttgcttt cggtgcaacc agcttctata tggctgtcac aggaagttca
     7561 gctttcgctg ccgcactttt taacattaat ccatttggca cttttattgt gtgtatcgtg
     7621 gcacgtgtgc tggaaggatg gatcacagga cttattttcg cagcattata taaatcaccg
     7681 gcgaagaaat tttcctatta cgttgcttca ctggcatgcc cgttactgaa tactttcttc
     7741 ttcatgggct ttttatgtct cttcttctac aacacagatt acattcaggg tattgtttcc
     7801 agtcttggag taagcaatcc tgttgtcttc gttgctgctt ttgtgggcgt tcagggactg
     7861 atcgaagcgg gcttctgctt tgtagtggga agcatcgttt ccaaggcact ttctgtggca
     7921 ctgaaacgtg cataatcttt aaaagaacag ccttttaatt ctgctgttcc ggaaggttca
     7981 ctaaaaatcc ctgactacat tgtcactgta gtcaggtttt ttttatcaaa aggagatttt
     8041 tatgtcatta ctaaaagaga tttctattac agagctttca aatttacgca tcggtcatac
     8101 ttctgaccat gatgcgaaga ccggtgtaac tgttctttat tttccaaatg gagcaaaagc
     8161 aggctgcgat ataagcggag gcggccctgc ttccagagaa actcctctca cctctcctgt
     8221 cactgccgac aatcctatca acgccattgt cttgtccgga ggttctgcct atggactggc
     8281 tgctgctgac ggtgtaatga actatctgga atcacaaaat atcggttata acaccggtgc
     8341 agcactggtt ccccttgtat gccagtcctg tatctatgac ctctcttacg gagatcctaa
     8401 aatacgtcca actgcaaaaa tgggcgagga agcctgccgt caggcatttg ccggaacaga
     8461 tgccagaacc gggaatatcg gcgcaggtac cggtgcaact gtgggaaaac tttacggtat
     8521 gaaacaatcc atgaagtcag gtcttggtat tgccgctgta tctgtgaaaa atttccagat
     8581 ggccgcaatt gtcgttgtca atgcactggg agatatcttc agtccacaaa atggtcagaa
     8641 aattgcaggg ctgaaaacac ctgacagaag cgggtttctg gacagtgtcc acgaattata
     8701 ccgctttatg acacctcatg accagtttac cggcaatacc accatcgggg ctgtgatcac
     8761 caatggggca ttttcaaagg ctgaactgaa taaaattgcc tctatgaccc gctgtgccta
     8821 tgccagatgc atcaatcctg tagcaactat ggctgacggc gattccatct atgctgccag
     8881 cattggcgat gtttctgtag atatcaatat ggcaggaact ctcgccgcag aagtcatggc
     8941 tcaggctatc caaaatgcca tccatacttc ccggatccag gatgaagaat ttctgaaata
     9001 tgtataacag tccgctataa aagcgcagag aaaaagtatc atctctgcgc ttttattctt
     9061 cctgtctgtc ttcatttttc atctgtgctc tggtttttct ccaagccaga gctgtacatt
     9121 tgcttcccgt tcccttgcca tatcaccaat agtacggatt ccctgattca gaagcttctg
     9181 ctcggaggct tttcccagaa ataacaggtt acggacagga agtggtcaca ttttctccga
     9241 tatttcgtcc gggaacagcg tgtgtactct gtccgtttct ttggatctcc tcccacacag
     9301 gagggaatct ccctgagatc cggcagcccc tggcttaccc ttctggctga ctcccaggaa
     9361 agaaatgcgc tgtttacatc aatatgaaaa attaatcgtt ccatactttt taatatatct
     9421 caatcatatt ttcgcagact tccaatcatc ttaatcccca gtatcatcaa cacagggaaa
     9481 atcagtgctg cgaagattcc aagtttcaga ttatcattca gtgctcctga aatcattccc
     9541 acataggttg gtccggatga gcatcctaca tctcccgcaa gagcaaggag ggcaaacagg
     9601 gctgttccgc cacgctttac cgaggcagcc gccatgctga aggttcccgg ccacataata
     9661 cctacagaca gaccgcaaac cgcacatcca agaattccca acgcaggtac cgggataaat
     9721 gcgatcatca gataggaaac catgcacaga actgcactgt attgcataaa gcgctccaga
     9781 ttgatcttat ccccaaattt cccataaaat gcccttgagc ttcccatgag aattgcaaac
     9841 gccatgggac ctgccagatc tcctatggtt ttattgattc caaagctttt ctcagccaga
     9901 gtagaagccc actggcttac cgcctgctca ctggctcctg cacagagcat cattaacatc
     9961 agaacccaga agattttttt cttaaaaagc tcccccatag tcagtccctt ttccccctca
    10021 tccaacagtg gagcaatggg aactctggta aaaaggattc catttgcaat gggaatcaat
    10081 gcccacacca gtgccatata tttccagttt gcaatcccga aaatacgaaa gaataatgta
    10141 gaaagaagta ccactcccac atgtccccag cagtaaaagg aatgaagaag actcattgct
    10201 ttttccttat tatctgtagg gcaggcttcc accacaggac ttaccagcac ctccagcaat
    10261 ccgcctccga tggcatagat cataactgca atgataagtc ccacaaacgt atctcccagg
    10321 cactccggca atactgtgag caaaatcaga cccgcagctg ccattgcatg tgccaggatc
    10381 atagatgcac gataaccgat tctgtccaca aatccaatcg atgccagatc taccagcaac
    10441 tggatcccga aattaaaggt aaccagaagt gtgatcttct gcagcgaaat cccataactg
    10501 ccctgaaatg tcagaaacag cagaggaaca aaattgttca caatggcctg cactacatat
    10561 ccgataaaac aggcctgcac tgttctgttg taatttgttt tcattcgaga tgatatcctc
    10621 caatctgaaa tttattagtt actgagaacg gagtgagcag taacatttat tatgcaaata
    10681 tcgttcaggc attctcattc atcaaattct gcaccttcac agttcaatct gtcaataatg
    10741 acagtgtatc acagattctt tcttttttct ttcattatat tttgaaaatc ctataaattt
    10801 ttatgttatt ttgacttttt ctcatataac aattctatac gatctaacag gtaatccaac
    10861 agtccgattc caaatatttc ccgcaaaaaa agatgtgtac catatcattt ctgacaccat
    10921 acacatctca aaataaacac ttcttatctt ctgtactccg cagtcaggtc tttaataacc
    10981 tctcctgcaa taatcagccc ggcgacagac ggcacaaacg ccacactccc cggaatatct
    11041 ctgcgctccg tacacttatg cgcggcaccc ggaggacaaa tacaatgcga cctgcagctg
    11101 attgccatat cttcaattgg tctgatcggc tgttcctctg aataaacaac cttcagtttc
    11161 ttcacaccac gcttcttcag ctctctgcgc ataaccttcg ccaacggaca cacctttgtc
    11221 ttatagatat ctgccacccg aaacgcactg gcatccagct tatttccggc acccatactg
    11281 ctgataacag gagtccctgt ctcctttgca cgcatgatca gttcaatctt cgcagtcact
    11341 gtgtccacag catctaccac ataatcatac tcactaaaat cgaaatcagc agcattctcc
    11401 ggaagataaa aacagttatg gattctcaca tctgctttcg gattaatgtc caggatcctg
    11461 tcccgcatca cctctgtttt atattgacca acagttttcc tggtggcaat aatctgtctg
    11521 ttaagattcg tcaggcatac tttgtcatca tcgatcagat caaaggtccc cacaccgctt
    11581 ctgaccaatg cttcacatac atatcctcca acccctccga ttccaaacac tgccacgcgg
    11641 gagttctcca gtttattcat tgcttctttt cccagaagaa gctctgttct tgaaaattga
    11701 ttcaacataa tatctccatt tcattcggta ttgaccgact atctgcctgc ctttcttcta
    11761 cttcattatt tctggtctgt tctgctttgc tgcctgtaat gtaagcagct ctgcatgcca
    11821 gaaacaaaaa aacaaggagc agaaaccaaa gccagagctt tcttttgttt tttatgagca
    11881 accgtttcat aatctgcatc actattcctt aatatattat tttcagatac cagagttgca
    11941 acatacttcc atcacagatt tcttatgata tctttacttc tataatgcgt caagtatatc
    12001 atagaaagaa aaatcctgca atgaagaaac tctgttactg tacatgaagt gaacagtgct
    12061 gagtgaaatt cacaaaccgg aagtgcttat ccatctcatc accaatcaat ccaattactt
    12121 ttcccatggt aaatgccgcc atcactgttc cgattcccag tccgttgata tgccccagga
    12181 tcagccctgt catacaggca gtaatcatca gacagatcac atcaaaagaa accttgatct
    12241 tagaatattt cacctttata atctctgaca gttcacgagg aaacagatct gtaggaataa
    12301 tcggcagacc gcatctgtta gaaagtgcga tccctataca gatcagcaga taactgatca
    12361 caaaatataa cactctgagt ggaattgtct ttggcaggat attgatccat gcctcattaa
    12421 catccaaaag ctcactgaat gcaaatccaa ccagaaaact gcacagataa gcaggtacaa
    12481 atttttttct cagtatcatc agacttaaga tcagaagtgc ctgaaaaata taagtccatg
    12541 ttcccagtgt aattaccgga aatacttttt caaatgcata aggaacactg gatatggcag
    12601 atattcctga accagaatac agcatcagaa taacagcaag actgttgatc atgactgcta
    12661 tcaccagtgc cagctctcct ctgaaaatat gtctcgaatc ttcttcctca tttgttttca
    12721 taacaattct ctcctctaac acaagcaagg gactgctgtc agaaaatatt ttctgtcata
    12781 cttttctgac ggcagacccc tgtgtctttt acatcttata ttttctgaaa atactatttt
    12841 ttatcgaatc aggcaagttt cccacttcaa ctactgatat tttcctgact tactcaaccg
    12901 tgcagacgcg gatcaggttt gttcttcccg gaattccaag cggtacacca ccggcaaata
    12961 caatagtgtc accaactttt acaagtttat gcttctgtgc tgcctcgatt gctctcaggc
    13021 aaaggatctc agaactgtat tcttctttga tcagcatcgg gtaaacaccc caggacagat
    13081 tcagctggcg aagaactctc tcagagcttg tacatgcacc gatcagacat cctggtctgt
    13141 gtttggacat catatgagct gtacttccgg attttgtcac tgaaaggatt gcactggcct
    13201 tcaggtcgat tgctgtcagg caggttgcat gtgcgattgc atttgtaata tccggattct
    13261 catttctgtc tgttttctta aagattgtat tgtaatcaat attctgttcc atatgttctg
    13321 caatgcggct catcatctga agtgcctgta ccggatattt acctgctgct gtttctccgg
    13381 aaagcatggt agcacttgtt ccctggaaaa tcgcattggc aacgtctgta gcctctgcac
    13441 gtgttggtct cggatgagag atcatggagt caagcatctg tgttgctgta ataaccggtt
    13501 ttcctgctgt gtaaactttc tggatgatct tctgctggat aacaggtaca tattccggcg
    13561 gaatctcaac acccatgtca cctctggcga tcatgatgcc atctgctgct tcaataatct
    13621 cgtcgatatt gtcaacgccc tgctggttct caatctttgc aatgatctgg atctcttcac
    13681 cgccgttttc tttcaggatt tttcttactt cgcggatatc gtttgcagta cgtgtaaagg
    13741 atgctgcaac gaaatcaaat ccttcctgga taccgaagag aagatcatca tgatctttct
    13801 tactgataaa tggcatcttc aggtttgcac ccggaacatt gacacccttc ttgtcgccaa
    13861 tcacacctgc attaataacc ttgcagacaa tgtcctttcc tgcgatgtcc tgaacctcca
    13921 ggtctacaag tccatcatca accagaatat gtccgcccgg ctgcacatcc ttataaagct
    13981 ctttataagt aatgcttacg cactcattag ttccttcaat atctttattt gtaaatgtaa
    14041 aaatctgtcc ttcttccaga gaaaccttgc catccttgaa gcatccaagt ctgatctccg
    14101 gtccctttgt atcaagaagt gctgcaacag gtctgtcata tttcttgcga agttctctca
    14161 gtttctggat acggcctctc tgctcatcgt gaggtccatg tgagaagttg aaacgtgcta
    14221 cgtccattcc ctctctcaca agctgctcca taacatcgcc cttatcagta gacggtccca
    14281 ttgtacagat aattttggtt tttctcattt aatctttccc tccaaactgt caactcaatt
    14341 ttatctattt tattcctgta aaataatgta ataaaatttt acctgtttct ataaatgaaa
    14401 acattaaatc aaataaaaat taccattatt gagactatct gtcaatatag aatttcgact
    14461 tatttttgtt gatatttgac aaaaaaataa catacttttg ttgcaaatat cacatatatt
    14521 tttgctgatc cgacagttgg aaaatttttc actcattctt atcagaatcc aaaatctgca
    14581 tagtcttccg gcagaaatct gtggtaaatg atatggcatc cttcatcttt aaaacaataa
    14641 taataaggat ctgatccatc atcaaagcgg atcatcacat caaactcctc gttatccatt
    14701 ggttcagtaa tgattttatc tgaataagaa tggaacagtt ctttaatttc ctctatcgta
    14761 catccatgtc tgccaaccag ttcgatcaat gccttgataa attcattctc tttcatatta
    14821 ttatgtacat attcggaagc tttttccgaa acagtgaagc agaaacgatc tcctctgtgt
    14881 gatactgcta cttcaccaaa tttctcttct atataagaag gaaaatcttt taaaatctcc
    14941 atcatgcctg cagcatccgt ctcattgcca aagaaatgat tcagggaact gagcggataa
    15001 taaaggctga tcttctcctt catatatcca agcttcgcct gttcctcttt gatcacatcg
    15061 atcagactgg tttctaatct gttatagttc atttattttc cctcctgaaa atctatcctt
    15121 ttgctttttc tggttaatat tttatcagac attgcccgaa aatcaatgca tttctttttc
    15181 aattgtacgc ccgccaaaac aattgcaatg ttttcttttt catacaaaaa taaagagctt
    15241 gcgaaactgt cctttttttc tccctctgac aaataactct gactggataa aacaaaacag
    15301 ataaaaccaa ccacttcgtt gcttttttaa ccaaataact gcttgattcg gttaaaaaaa
    15361 cagcgttccg aatattattt atatccgaaa cgctgtcatt attccaatta tttcattatg
    15421 tatttaatcc cagttcttac gtccgtaacg aagtgtcaca tcatatattt ccttctggag
    15481 tttctttgta agatctctct tcttgattct ccacttccag ttcgtaccaa ctgtagatgg
    15541 tttattcatt cggaatctgt tgtccagtcc catatagtcc tgcattggga taacgcagac
    15601 acgcgcagca ctgcgcatga tcagactgat gaaacattta tacagttctt cttccggtgt
    15661 tgcatgatca cacagataat ctctcgccag ttttctctca gctgctgtga tgctcttcca
    15721 ccatcccacg atagtttcat tatcatgggt tcctgtatat gccacgcagt tctccggata
    15781 attatgtggc agataatcac tggcacatcc agaatctctg gagtcaaacg caaattccag
    15841 aactttcatt cccgggaagc cactctcata taccagatga cgtacagaat ctgtcatata
    15901 tcctaagtcc tctgcgataa cctgcttcca tccaagcgcc tgttcaatct tacggaacag
    15961 atcaattccg ggaccctttt cccagtgtcc gcctcttgca tctttatctc cgtatggaat
    16021 agagaaatat tcatcaaatc cgcggaaatg atcgattctt acaacatcat acagtctgaa
    16081 gcagtaactc attctggaaa tccaccactg atatcctgta tttctgtgat aatcccagcg
    16141 atataacgga tttccccata actgaccggt tgcagaaaat ccatccggag ggcatcctgc
    16201 tactgccagt ggtacattat cctgatccag ctggaacagc tccggatgcg cccatgcatc
    16261 agcactgtcc attgcaacat aaatcggaat atctccaatg atctggattc cttttgaatt
    16321 tgcataggat ttcagtttca tccactgctc atagaactta aactgcatat actgctggaa
    16381 ttcaatatca aaatagagtt cttcacgata ataatccatg gcattgttcc agcggagtct
    16441 gatatcctca gcccatttgg tccattctac accttcgaaa cggtctttta ctgccataaa
    16501 cagagcataa tctgacagcc accagctgtt ctctgctacg aatttctgat agtcaggatt
    16561 cttgctgata tcactgttct cgtatgcttt tctcagaaga ggataacggc ctttgtagat
    16621 tttttcataa tctacctcat caggcttctt tccccagtta actttctcgc agtctttctt
    16681 atcaagaact ccttcttcca caagtgtatc cagatcaata aaatatggat tacctgcaaa
    16741 tgtagagaaa gactgatatg gagaatctcc atagctggtc ggtcccaatg gcagaatctg
    16801 ccagtaagtc tgtccggctt cctttaacca gtctacaaat tcatatgcac ttttggaaaa
    16861 acatccgatg ccatagtctg atggaaggct gctgatcggc attaatattc ctgctgctct
    16921 ttttc
//
