LOCUS       gnlProkkaCIFKKMLO_121  11844 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CIFKKMLO_121.
ACCESSION   gnlProkkaCIFKKMLO_121
VERSION     gnlProkkaCIFKKMLO_121
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 13:54:53
            Original ID  :: gnl|Prokka|CIFKKMLO_121
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11844
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11844
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[8815:11797]"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      8816..11797
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     cand_cluster    1..11844
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11844
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX))"
                     /tool="antismash"
     CDS             663..827
                     /locus_tag="ctg121_1"
                     /transl_table=11
                     /translation="MEIDFIQELKKRDELLDGYLRQIEIQEEFIQKQKELIEYLEDHIS
                     KITDIVGSV"
     CDS             852..1772
                     /locus_tag="ctg121_2"
                     /transl_table=11
                     /translation="MPDTYDHITLMCRLKAAQRRNKELESGERYIQLEELHQKEYNVYE
                     HKIEKLKKELADAHKETIRVRNYWFQVLEDMLREFEKAQKRSAQELRKMEIRALNAEKQ
                     REDALDKAAVFRHQFYEAASRLEEEQGKNLKLRAQINRDYENSSIPSSKAVRRKKITNN
                     REKTGRRPGGQPGHKGHCWKRQEPTQPVILLPPPEEVLEDCAFKKTARTIVKQMVSIRM
                     VLNVTEYHADVYYNSHTGERAHAAFPDGVIDDVNYDGSIRAFLFLLNNDCCTSIDKSRT
                     FLSDLTGGKLNISKGMISRLNRSLL"
     CDS             2311..2967
                     /NRPS_PKS="Domain: ACPS (101-164). E-value: 1.2e-09. Score:
                     30.0. Matches aSDomain: nrpspksdomains_ctg121_3_ACPS.1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1012:4'-phosphopantetheinyl transferase (Score: 104.8;
                     E-value: 6.7e-32)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg121_3"
                     /transl_table=11
                     /translation="MIPEYTSCQEGCSGIPFFTVLMTVYRVTQRQATKSLYCHLKLPST
                     LLVRMEISKLSGIPSADLCFHSQYMHKPILLSAPQYHFNYSHTRNMILCGISATEPVGV
                     DIERIDTNITIGNMENVFHPIEFLYINNGSSAPIRSYRFYKIWTQKEAYIKYLGTGFSE
                     KIQDFNTLDSSFSFHLHTWIVNDYLCSMFLPSLSNPTIQLVNESDVQHYFLNTFI"
     aSDomain        2614..2802
                     /aSDomain="ACPS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg121_3_ACPS.1"
                     /evalue="1.20E-09"
                     /label="ctg121_3_ACPS.1"
                     /locus_tag="ctg121_3"
                     /protein_end="164"
                     /protein_start="101"
                     /score="30.0"
                     /tool="antismash"
                     /translation="VGVDIERIDTNITIGNMENVFHPIEFLYINNGSSAPIRSYRFYKI
                     WTQKEAYIKYLGTGFSEK"
     CDS             complement(3077..4651)
                     /NRPS_PKS="Domain: AMP-binding (29-427). E-value: 1.5e-79.
                     Score: 259.4. Matches aSDomain:
                     nrpspksdomains_ctg121_4_AMP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     344.1; E-value: 1.9e-104)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg121_4"
                     /sec_met_domain="AMP-binding (E-value: 5.5e-83, bitscore:
                     268.4, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDRKVTKRELIDYEQFGCYQHCTIDQYFKNIVDHYKDRIALVDGI
                     HRYTYSELDIEIQKCVMYCLKNGISQGDNVLIQLPNSDSFIIFCFALFRIGAVPVAALP
                     AHRKNEIEGIIEATHPVAYILKEIYQGFNYYKFAQDIRKHTAFKFNIISDNSYKDTSYD
                     GEEIINTRDYKDIAYLMLSSGTTGKPKIVPVSHAMLMSMSLEATKKLRIDQNSVYLDIL
                     PISHKFAFSEPGILGTLLNGGKVVICKFMSWDEAFPLIEDEKVTFTAVVPSLVKILNEM
                     FEITESYDLTSLKFIQIGGAAIEYNSVKLLNKIFDCAVVPFYGATEGAVTCTSLDDTLE
                     VMGNTCGKPLALYDEIVIVDEKGYEVKEGDVGEVWVRGPYTITSYFDKKDNEGRFTSNY
                     FYKMGDLARYREDGNIQIVGRKSEMINRAGEKIVPAEIEFILKENSKIKDAAVIAVPDE
                     MLGERICAFIVANSYMSVKDIGSHMIQKGIALYKIPDQIIFVEQLPLTANYKVDKKKLL
                     CMVLNTE"
     aSDomain        complement(3371..4564)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg121_4_AMP-binding.1"
                     /evalue="1.50E-79"
                     /label="ctg121_4_AMP-binding.1"
                     /locus_tag="ctg121_4"
                     /protein_end="427"
                     /protein_start="29"
                     /score="259.4"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="NIVDHYKDRIALVDGIHRYTYSELDIEIQKCVMYCLKNGISQGDN
                     VLIQLPNSDSFIIFCFALFRIGAVPVAALPAHRKNEIEGIIEATHPVAYILKEIYQGFN
                     YYKFAQDIRKHTAFKFNIISDNSYKDTSYDGEEIINTRDYKDIAYLMLSSGTTGKPKIV
                     PVSHAMLMSMSLEATKKLRIDQNSVYLDILPISHKFAFSEPGILGTLLNGGKVVICKFM
                     SWDEAFPLIEDEKVTFTAVVPSLVKILNEMFEITESYDLTSLKFIQIGGAAIEYNSVKL
                     LNKIFDCAVVPFYGATEGAVTCTSLDDTLEVMGNTCGKPLALYDEIVIVDEKGYEVKEG
                     DVGEVWVRGPYTITSYFDKKDNEGRFTSNYFYKMGDLARYREDGNIQIVGRKSEMINR"
     CDS_motif       complement(4064..4123)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg121_4_0001"
                     /evalue="1.40E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg121_4"
                     /protein_end="196"
                     /protein_start="176"
                     /score="20.8"
                     /tool="antismash"
                     /translation="AYLMLSSGTTGKPKIVPVSH"
     CDS             complement(4644..5054)
                     /locus_tag="ctg121_5"
                     /transl_table=11
                     /translation="MEKSAEIKSVISCSGFNSTKELFESYMQAVWLKGISLCVSLYEYI
                     IFGKRSTYKGTDGINKSNVKVLVLHSLYDDVLPFESGIVARKCMITNKRAICVECNKKG
                     HNILRRVDDESKLDEEQMVKLLDFMRGENNNG"
     CDS             complement(5169..6332)
                     /gene_functions="other (smcogs) SMCOG1229:transposase
                     (Score: 329; E-value: 4.8e-100)"
                     /gene_kind="other"
                     /locus_tag="ctg121_6"
                     /transl_table=11
                     /translation="MPALPYSITISDEERAYLKSLIKTRTIQAQVVDRARMLLWKSEAQ
                     TDKAIADGLGVSVNTVRRCIDRYLNSGINLAVFDDERSGRPAEITDDAKSWIVSIACQK
                     PCDLGYAAELWTLAALHKHIQAHAEKAGYPRLKTVTKPWLQKYLKKMEMKPFKIKYYLE
                     RKDPDFENKMHDVLLVYKQVEMQFDDNGNITIPDNGHLTHTISYDEKPGIQAVANKYPD
                     HNPTEDNGYIRRDYEYVRLGTLSLLAGIDLLTSEAIPLVSQTHKSSDFIQFLKILDAKY
                     PEGDTIRLILDNHSAHTSKETRQFLAALPEDRLVFVFTPTHTSWLNMIESFFSKMTKQM
                     LKGIRVNSKEELSERIYRYFDEINADPIVYHWTYKMDEIDPDEAATI"
     CDS             complement(6406..6537)
                     /locus_tag="ctg121_7"
                     /transl_table=11
                     /translation="MRFVQFLFFRHALGLDITGCGKSSGKCMKGFTQWVIDLYEVLV"
     CDS             6587..6985
                     /gene_functions="other (smcogs) SMCOG1097:transposase
                     (Score: 114.8; E-value: 7.1e-35)"
                     /gene_kind="other"
                     /locus_tag="ctg121_8"
                     /transl_table=11
                     /translation="MLRRYELTDEEWLRIEPLLPPENTGKQGRPRKDNRIIMNGIVWLA
                     RSGAPWRDLPERYGSWKTVYSRFRKWIDDGILDNIFRILSLEAELEELSIDASIIQAHQ
                     HSAGAKKGDLQMKSGIAVEEPAPKSMRQ"
     CDS             7012..7350
                     /gene_functions="other (smcogs) SMCOG1097:transposase
                     (Score: 93.8; E-value: 1.9e-28)"
                     /gene_kind="other"
                     /locus_tag="ctg121_9"
                     /transl_table=11
                     /translation="MISEGQRNDINYAIPLLDQIEINGSNVLADRGYDSNKLLDYVYAR
                     GGEPTIPSRKGAKFERHCDWWLYKERHLVEKYFLKLKAFRRIATRYDKLAATYLGFICI
                     ASILIWLK"
     CDS             complement(7368..7697)
                     /locus_tag="ctg121_10"
                     /transl_table=11
                     /translation="MWVLYFLSFLVIIHILIARLFYHKRFGHRIECSEEKMLEVALKYP
                     QLKYVSIKVKSGISVLNCSMYYHSELRKADELVIIVHGYGNTHVDYMDEIYYFCRMGYD
                     VLERV"
     CDS             complement(7699..8802)
                     /locus_tag="ctg121_11"
                     /transl_table=11
                     /translation="MQNERFTIEETRQMVEKMEDVVLDSIIYTVQQRGVLNDAATIYNF
                     KEILDRLNCQQQYCHIINRWIKALVQRGRIKPASGDGYYGTSHVTEELVEQKWDEARKM
                     WDYRFGSPLVMEYWYMNFRNLLDLIKGKTQAVFLLFPQGEDKYAKALYSDTKIAQYINL
                     KMVDIIEGHFRAFCKESTDKLKILEIGGGTAATTEMVLKALEVNSDITKIEYNFSDISK
                     FFLIRAKKIFEKYDFVKYRILDVDCVKKGLLFDKEKFDIVIAAGVLNNAYSIEATLAAL
                     YDILEEGGLFIFSEPIQESLEILISQAFMITKPKDIRMDCEETFMTKEQWEKVISNSGF
                     MIKTIYPQEDEPMAVFGQRVFAVIKEN"
     CDS             complement(8816..11797)
                     /NRPS_PKS="Domain: cMT (326-473). E-value: 3.4e-30. Score:
                     96.1. Matches aSDomain: nrpspksdomains_ctg121_12_cMT.1"
                     /NRPS_PKS="Domain: PP-binding (610-681). E-value: 1.8e-07.
                     Score: 23.5. Matches aSDomain:
                     nrpspksdomains_ctg121_12_PP-binding.1"
                     /NRPS_PKS="Domain: Thioesterase (714-986). E-value:
                     1.5e-12. Score: 40.3. Matches aSDomain:
                     nrpspksdomains_ctg121_12_Thioesterase.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score: 90.7;
                     E-value: 1.2e-27)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg121_12"
                     /sec_met_domain="AMP-binding (E-value: 4.3e-34, bitscore:
                     107.3, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 3.9e-08, bitscore:
                     23.5, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLVAFRKRLSNYYLCEEIDDSLGSVPYGKPLSNQYFKILDKKMR
                     MCPLYVSGELYIGGQSLADCYYNDTYTTSSHFIDYTENERLYKTGDYGYYKESGDIIFQ
                     GRRDEQVKLRGYRIELGEVEAALQKNPLVKQAAVVINKAGAEATLNAFIKLQDDAESIN
                     TFQLSNITQTQIKELYNDIFAEYEAEKIALANSILEEYVLYSILEYLKENHLTQNKKID
                     FSLMKQKESIKSEYHWLIKRWLDKLCECGKLVSTNEDVYELKSDNINEKVKIYRESLYS
                     TWNNEIMPETFILYIEENLKQISGLLSGKVNPVDILYPYGEWKIVRDLYINSKVSHYIN
                     SCIEELIQNMLSYNNERTIRILEIGAGTGAVLEKISGILEKSNIEYYFSDVSSFFITTA
                     KAKYQHPNIKFGIYNIDEDYRKQGLLPNMFDMIIAVEVVENAKNIPYTMQMLKELIAPK
                     GWLVLSESVIEPAWILASQAFLMQEPQDDLRKNTSYLGQSDWIKLLMEIGEGDMYSWPE
                     QGSSIDSFGIRLFAKQVKKQMPHYDLDEIKDGLKKELAGYMIPSNMQVIDSLPLTANRK
                     IDRRVLERWSDIGQFGSNSQQEEIISDERSEEQKKIEKIFKDSLGVDAIEWNRSFYEYG
                     ADSLIIAQIAGKIMQFLNEEQGMDIPYDVILRQLLNQSTLEKFEEFVDTYGTKNADDGD
                     DKKNNYEVIRYIESEEETACVLFHGGLGTLDNYRNLVKYLQCGEQIEVIGFAIKDSFKY
                     CKISPENLYQAISLEYAAYIQKRGIKKVQLVGHCIGGRIAVEVARILSEKGIKIVDVVL
                     IDSVPLMSNVPDDSYLELMFPAFLNISFKDMGLTDLSTTEIMNEMILLLEGDDKADNRL
                     KKLLDKLKTLDETKKISMYADTLLRLYGKRIPNDMVKSMLNAFIHSSKGAKYEPEPYIG
                     DIRLLLAKEQYFPVRNLTEKAIQFWKDICIGNLQTMTILGNHFTCIEDEKNAAMVANLI
                     LKHI"
     aSDomain        complement(8840..9655)
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg121_12_Thioesterase.1"
                     /evalue="1.50E-12"
                     /label="ctg121_12_Thioesterase.1"
                     /locus_tag="ctg121_12"
                     /protein_end="986"
                     /protein_start="714"
                     /score="40.3"
                     /tool="antismash"
                     /translation="VLFHGGLGTLDNYRNLVKYLQCGEQIEVIGFAIKDSFKYCKISPE
                     NLYQAISLEYAAYIQKRGIKKVQLVGHCIGGRIAVEVARILSEKGIKIVDVVLIDSVPL
                     MSNVPDDSYLELMFPAFLNISFKDMGLTDLSTTEIMNEMILLLEGDDKADNRLKKLLDK
                     LKTLDETKKISMYADTLLRLYGKRIPNDMVKSMLNAFIHSSKGAKYEPEPYIGDIRLLL
                     AKEQYFPVRNLTEKAIQFWKDICIGNLQTMTILGNHFTCIEDEKNAAMVA"
     aSModule        complement(8840..10819)
                     /domains="nrpspksdomains_ctg121_12_cMT.1"
                     /domains="nrpspksdomains_ctg121_12_PP-binding.1"
                     /domains="nrpspksdomains_ctg121_12_Thioesterase.1"
                     /final_module
                     /incomplete
                     /locus_tags="ctg121_12"
                     /tool="antismash"
                     /type="unknown"
     CDS_motif       complement(9398..9454)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg121_12_0003"
                     /evalue="2.80E-05"
                     /label="NRPS-te1"
                     /locus_tag="ctg121_12"
                     /protein_end="800"
                     /protein_start="781"
                     /score="16.7"
                     /tool="antismash"
                     /translation="QLVGHCIGGRIAVEVARIL"
     aSDomain        complement(9755..9967)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg121_12_PP-binding.1"
                     /evalue="1.80E-07"
                     /label="ctg121_12_PP-binding.1"
                     /locus_tag="ctg121_12"
                     /protein_end="681"
                     /protein_start="610"
                     /score="23.5"
                     /tool="antismash"
                     /translation="KIEKIFKDSLGVDAIEWNRSFYEYGADSLIIAQIAGKIMQFLNEE
                     QGMDIPYDVILRQLLNQSTLEKFEEF"
     aSDomain        complement(10379..10819)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg121_12_cMT.1"
                     /domain_subtypes="cMT"
                     /evalue="3.40E-30"
                     /label="ctg121_12_cMT.1"
                     /locus_tag="ctg121_12"
                     /protein_end="473"
                     /protein_start="326"
                     /score="96.1"
                     /tool="antismash"
                     /translation="RDLYINSKVSHYINSCIEELIQNMLSYNNERTIRILEIGAGTGAV
                     LEKISGILEKSNIEYYFSDVSSFFITTAKAKYQHPNIKFGIYNIDEDYRKQGLLPNMFD
                     MIIAVEVVENAKNIPYTMQMLKELIAPKGWLVLSESVIEPAWI"
     CDS_motif       complement(11426..11491)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg121_12_0002"
                     /evalue="9.70E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg121_12"
                     /protein_end="124"
                     /protein_start="102"
                     /score="33.7"
                     /tool="antismash"
                     /translation="FQGRRDEQVKLRGYRIELGEVE"
     CDS_motif       complement(11573..11656)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg121_12_0001"
                     /evalue="3.20E-07"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg121_12"
                     /protein_end="75"
                     /protein_start="47"
                     /score="22.7"
                     /tool="antismash"
                     /translation="PLYVSGELYIGGQSLADCYYNDTYTTSS"
ORIGIN
        1 aacattttat aaaaaaagaa atgttttcca ttcccttatt tgcttacgga aaacgtttct
       61 tttcatttac tcttcatgaa gatttccgtt ctcatcgatc caggttccgt ctccgttatt
      121 gtaaaggact ctggattctt catcaccttc acctgctgct acaatttcca ttctgttcat
      181 cggaggtgta ttattccaaa gaacaagcat aatatccagt tctgattctg gaagtctctg
      241 atatgttttt ttcacgctct cattctccct ctttctacaa atgtaggaac gattttatta
      301 tatcatatca gtctatttct gtatagctgt ttccattctc atcagagatt tcgcttttag
      361 tttgttactg ttcaaaggta tgtataagtc attgtaaaaa gtgacgaaat tattttctct
      421 attttgtgga taattatctt cagcagaaaa aactgtattt atagtttttt ctgctgtttt
      481 ttttcacaaa agttatacac cgaatcctat ccattctttc agacagaggc cttatatctg
      541 ctcatttcca atcttataat ggagatttat ccacagtcag attgcccaat gggtcatttc
      601 cggaaattcg cttttttcct gcatttctgc tatacttttt tcaagaaaga gaggttgttt
      661 ttatggagat tgattttata caggaactaa aaaaacgtga tgaacttctt gacggctatc
      721 tcaggcagat cgagatccag gaggaattca tccagaaaca gaaagagctg atcgaatatc
      781 tcgaggatca tatctcaaag atcacagata tcgtcggcag tgtttagcag gactgtaccg
      841 gaggaaaacg tatgcctgat acttatgatc atatcactct catgtgtcgg ctgaaagctg
      901 cacaacgcag aaacaaagaa ctggaatctg gtgaaagata tatccagtta gaagaacttc
      961 atcagaaaga gtacaacgtt tatgaacata agattgagaa gctgaaaaaa gaacttgcag
     1021 atgcgcacaa agaaacgatc cgtgtgcgca attactggtt tcaggtactg gaggatatgc
     1081 tccgggagtt tgaaaaggca caaaaaaggt ccgcgcagga actccgaaaa atggagatcc
     1141 gtgcactgaa tgcagaaaag caaagagagg atgcactgga taaagcagcc gttttcagac
     1201 atcagtttta tgaagcggca tccagactgg aagaagaaca gggaaagaat ctgaaactac
     1261 gggcacagat caaccgtgat tatgaaaact cttctattcc ttcttcaaaa gcagtacgac
     1321 gtaaaaagat cacaaacaac agggaaaaaa caggcagaag accaggcggg cagcccggcc
     1381 acaaagggca ctgctggaaa agacaggagc ctacacagcc agttattctt cttcctccac
     1441 ctgaagaagt gctcgaagac tgtgctttta aaaagactgc caggaccatc gtaaagcaga
     1501 tggtaagtat ccgtatggtc ctgaatgtaa cggaatatca tgcagatgtt tattataaca
     1561 gtcatacggg agaacgtgca catgcagcat ttccagacgg agttatcgat gatgtgaatt
     1621 atgatggcag catacgggca tttctgttcc ttctgaacaa tgactgctgt acatccattg
     1681 ataagagcag gacatttctg tccgacctga cgggtggaaa actgaatatt tccaaaggca
     1741 tgataagcag actaaaccgg agtttgcttt aaaaactgag cctgaacgca ggtctgccta
     1801 tgcagatatg ctgctttccc ctgttatgca tacagattgt acaaatgcca gggaaaacgg
     1861 aaagagctgc caggtatatg tctgtgcaac accggacgga aaagccctgt actttgcctg
     1921 cgagaacatg cacaaccatc tgttgttcct gcatgatatc cgggtacctg ccacgaataa
     1981 tgaagccgaa aggcttctaa ggaattataa gcggaaacag gcgcaggccg tgacattcag
     2041 aagtttcgaa aacatcgatt atctctgcca atgcatgagc atgcttgttt tgatgcgcct
     2101 tgaagatccg gcaaatatat atgacagagt gttcagaata tttggataaa gaaaaccgat
     2161 ggttttgact gttatcagtc tacaccatcg gttttctcaa gtccagctaa cccttgaaca
     2221 gtaactatgg cgctgctttt aattaaaaat atcgtcttcc tcattgtacg aaacggaata
     2281 atctgatata ataatcatgg tttcaaaatc atgatcccag agtatacgtc ttgtcaggaa
     2341 ggatgctctg ggatcccttt ctttactgta ttaatgacag tatacagggt aactcagaga
     2401 caggcaacaa agtctttgta ttgccatcta aagttgccat caacactttt ggttcgtatg
     2461 gaaatcagca aattatccgg aattccatct gctgatctat gctttcatag tcagtacatg
     2521 cataaaccta tactactctc cgctccacaa tatcatttta attattcgca tacccgaaat
     2581 atgattttgt gcggtatttc tgccactgag ccagtaggcg tagatattga gcgtatagac
     2641 acaaatataa ccattgggaa tatggagaat gtatttcatc cgatagaatt tctatacata
     2701 aacaacgggt cctctgctcc tatacgctca taccgttttt ataagatttg gactcaaaaa
     2761 gaagcttata taaaatatct aggcacaggt ttttctgaaa aaatccaaga ttttaatacc
     2821 ttagattctt cattctcatt tcatcttcat acttggatcg taaatgatta tttgtgttct
     2881 atgtttctac catcattatc caatcctact atccaattag taaatgagtc tgacgttcaa
     2941 cattattttc ttaacacctt catataattt acagtcccaa aactccttct gagaaattat
     3001 gaggatttag aatacgttga acataataac ctatacaata aagaaggctt ccttcccaaa
     3061 atactttata tattttctac tctgtgttta aaaccatgca aagaagtttc tttttatcaa
     3121 ctttataatt tgcagtaagc ggcaattgtt caacaaatat aatttgatcc ggtattttat
     3181 ataaagcaat tcccttctgg atcatatgtg agccaatatc ttttacactc atataactat
     3241 tagccacaat aaaagcgcat attctttcac ctaacatttc atctggaaca gcaataactg
     3301 ctgcatcctt tattttagaa ttttccttta aaataaactc aatttccgca ggtactattt
     3361 tttctcctgc acgattaatc atttcagatt tcctacctac aatctgtata tttccatcct
     3421 ctctatatcg agctaaatct cccattttat aaaaatagtt tgatgtaaac cgtccctcgt
     3481 tatccttttt atcaaaataa cttgttattg tatagggacc tcttacccac acttctccaa
     3541 catcgccttc tttgacttca taccctttct catctactat tacaatttca tcatatagag
     3601 ccaaaggctt accgcaggta tttcccataa cttctaaagt gtcatcaaga gaggtacacg
     3661 taactgcgcc ttcagtcgcg ccataaaatg gcactacggc acaatcaaat attttgttaa
     3721 gtaatttcac cgaattgtat tcaatagctg caccccctat ctgaataaat ttcaatgaag
     3781 tcagatcgta agattccgtt atctcaaaca tttcattcaa aattttaacc aatgaaggaa
     3841 caacagcggt aaaggttacc ttctcatctt ctataagagg aaacgcctca tcccaactca
     3901 taaacttaca tatcacaacc ttgcctccat taagcagtgt tcctaaaatc cccggttcgg
     3961 aaaaagcaaa tttatgagaa ataggtaaaa tatctaaata cacactattt tgatcaattc
     4021 ttaatttttt agtggcttct aatgacatgc tcatcaacat tgcatgtgac actggaacta
     4081 tcttgggctt tcctgtagtg ccactcgaca acattaagta agcaatatct ttgtaatcac
     4141 gtgtatttat tatctcctca ccatcataac ttgtatcttt ataagaattg tcactaatta
     4201 tattaaattt aaaagcagta tgtttcctta tatcctgtgc aaacttataa tagttaaatc
     4261 cttggtaaat ttcttttaaa atgtacgcaa caggatgtgt agcctcaatt attccttcta
     4321 tctcattttt tctatgcgct ggtaacgcag ctacaggaac ggcacctatt cggaataatg
     4381 caaaacaaaa aataataaaa gaatcactat tcggcaattg aataagtacg ttatctcctt
     4441 gagaaattcc gtttttcaaa caatacataa cacatttttg aatttctatg tctaactctg
     4501 aatatgtata tctatgtatg ccatcaacaa gggctattct atccttataa tggtcaacga
     4561 tatttttaaa atattgatct attgtacaat gctgatagca tccaaattgc tcataatcaa
     4621 tcagttcacg ttttgtaact tttctatcca ttgttatttt ctcctctcat aaaatccaat
     4681 aacttaacca tttgttcttc atcaagttta ctttcatcat ccactcttct caaaatattg
     4741 tgcccttttt tattgcattc aacacatatt gctcttttat ttgttatcat acattttctg
     4801 gcgactattc cactttcaaa aggtaataca tcatcatata aactgtgtaa taccaatact
     4861 tttacattac ttttattaat accatcagtg cctttatatg ttgagcgttt accaaatatt
     4921 atatattcgt acaacgaaac acacaaactt atacccttta accacactgc ctgcatgtat
     4981 gattcaaaca attctttagt ggaattaaat cccgaacaag aaatcactga ttttatttca
     5041 gcactttttt ccatcagtac tgctgtaact gtatatccgc caacgctatg tccaattaaa
     5101 tgaatttttc cattatacct tttgacaacg ctgctatcta gtacaacgaa tattaaattg
     5161 ttgatagttt aaattgtcgc tgcttcatct ggatctattt catccatttt atatgtccaa
     5221 tgatagacta tcggatcagc attgatctca tcgaagtagc ggtatattcg ttctgatagt
     5281 tcctcctttg aattaacacg aatgcccttt aacatctgct ttgtcatttt gctaaagaag
     5341 ctttcaatca tgttcagcca cgaggtatgt gtcggagtaa atacaaacac caaacgatct
     5401 tctggcaatg ctgcaagaaa ctgacgtgtt tcctttgaag tatgcgctga gtgattgtcc
     5461 aatatcaacc ggattgtgtc accctctgga tattttgcat cgagaatctt taaaaactga
     5521 ataaaatcag aacttttgtg tgtctggcta accaatggaa ttgcctcgct tgtcaggaga
     5581 tcaatacctg caagcaagga cagcgttcca agccgtacat actcataatc ccgacggata
     5641 taaccgttgt cctctgttgg attatggtcg gggtatttgt tggcaacggc ctgaatgccc
     5701 ggtttttcat catacgaaat cgtatgtgtc aaatgcccgt tgtccggtat ggtgatattt
     5761 ccattatcat caaactgcat ttccacctgc ttataaacca agaggacatc atgcattttg
     5821 ttctcaaaat cagggtcttt gcgctcaaga taatacttga ttttgaacgg tttcatctcc
     5881 atttttttga gatatttttg aagccatggt tttgtaactg tttttaagcg tggatagccg
     5941 gctttttccg catgtgcctg tatgtgtttg tgcagtgctg ccaatgtcca taattctgcg
     6001 gcataaccga gatcacaggg tttttggcag gctatactga caatccatga ttttgcatcg
     6061 tcggtaatct cagccgggcg gccggaacgt tcatcatcaa atacagcaag gttaatacca
     6121 ctgttgagat aacggtcaat acagcggcgg acagtattca cgctaacacc aagaccatca
     6181 gcaatcgctt tgtctgtttg ggcttcagac ttccatagca gcatacgggc acggtcaaca
     6241 acctgtgctt ggatagttct ggttttaatc aatgatttca gataggcacg ttcctcatct
     6301 gatattgtta tactataagg taatgctggc ataattgacc tccataaaat atattgacta
     6361 agtccattgt accagatatt gaaactatca acaacttaat ttatattata ctagtacttc
     6421 atataaatct ataacccatt gagtaaatcc tttcatacat ttccctgaac tcttaccaca
     6481 tcctgttatg tccaatccta gagcgtgtct gaaaaataaa aattgcacaa aacgcatgtt
     6541 ttatttccct ttttcatgat aaaataaaga aaaaggggtg ttcactatgt tgagacgata
     6601 tgagttgact gatgaagaat ggcttcgcat tgaaccttta ttacctcctg aaaatactgg
     6661 aaaacaagga cgtccaagga aagacaatcg tatcattatg aatggaattg tatggcttgc
     6721 acgtagtggg gcaccttggc gcgatcttcc tgaacgttat ggttcatgga aaactgtcta
     6781 tagccgattc cgaaaatgga tcgatgatgg tatccttgat aatattttcc gtattttaag
     6841 tcttgaagca gaattggaag aattatccat tgatgcttct attatccagg cgcaccagca
     6901 tagtgctggt gcaaaaaaag gggaccttca aatgaaatcg ggcatagccg tggaggagcc
     6961 agcaccaaaa tccatgcggc agtagatgcc tatggatatc cagtttattt aatgatcagt
     7021 gagggacagc gtaatgatat caattatgca atccctttgc tcgatcaaat tgaaataaac
     7081 ggaagcaatg tgttagctga ccgaggatat gacagtaata aattacttga ttatgtgtac
     7141 gcccgcggtg gagagccaac cattccatcc cgaaagggag ctaaatttga acgtcattgt
     7201 gattggtggt tatacaaaga acgccattta gtagaaaagt attttctgaa attaaaagca
     7261 ttccgacgaa tcgccacacg ttatgacaaa ttagctgcaa cttacttggg atttatttgt
     7321 atcgcctcaa tattaatttg gttaaaataa acaatttaaa atgtttttca gacacgctct
     7381 agaacatcat atcccattct gcaaaaataa tatatttcat ccatataatc tacatgtgta
     7441 ttgccatatc catgtacaat aattacaagt tcatcggctt ttcgtaactc tgagtgataa
     7501 tacatagaac aatttaaaac actaataccg cttttaactt taatacttac atactttagt
     7561 tgaggatatt ttaaagcaac ttccaacatt ttttcttctg aacactcaat acgatgtcca
     7621 aaccgtttat gataaaataa ccttgcaatc aaaatatgga taataactaa aaaagacaga
     7681 aaatatagta cccacatatt aattctcctt tatgaccgca aaaacacgtt gtccaaaaac
     7741 tgccattggc tcatcttcct gtggataaat tgttttaatc ataaaacccg aattagaaat
     7801 cactttttcc cattgctctt tagtcataaa agtttcttca caatccattc taatgtcttt
     7861 tggctttgtt atcataaacg cttgggatat taaaatctct aaagactctt gaattggttc
     7921 cgaaaagata aacagacctc cttcttctaa aatatcatag agagcagcca gtgtcgcttc
     7981 gatactatac gcattattta gtactcccgc cgcaatgaca atatcaaact tctctttatc
     8041 aaaaagcaat ccttttttta cacaatcaac atctaatatt ctatacttta caaaatcgta
     8101 tttttcaaaa attttttttg ctcttattaa aaagaatttt gatatgtcag aaaaattata
     8161 ttctatcttg gtaatatcgc tatttacctc aagtgctttt agaaccattt ctgttgttgc
     8221 cgccgtacct cctccaattt ctaaaatttt tagtttatca gtagattctt tgcaaaatgc
     8281 cctaaaatgc ccttcgataa tatcaaccat ctttaaatta atatactgcg caattttagt
     8341 atcactatat aaagcttttg cgtatttatc ttctccttgt ggaaaaagca aaaaaaccgc
     8401 ttgtgttttg ccttttatta gatctaaaag gttacgaaaa ttcatatacc aatattccat
     8461 aaccaacgga gaaccaaatc tataatccca cattttcctt gcttcatccc atttttgttc
     8521 tactaactct tcagtcacat gacttgttcc atagtatccg tccccagagg caggtttaat
     8581 cctgcccctt tgaactaacg cctttatcca gcgattgata atatgacaat actgctgctg
     8641 gcaatttaat ctatccaata tctctttaaa attatatatt gtagcagcat cattaagcac
     8701 tcctctctgc tggacagtat atattataga atctaatacc acatcctcca ttttttcaac
     8761 catttgcctt gtctcttcaa ttgtaaatct ttcattttgc atttcttttc tcctgttata
     8821 tatgttttaa tataagatta gcgaccatag ctgcattttt ttcatcttcg atacaagtaa
     8881 aatgatttcc caatatagtc atagtttgaa gattcccaat acatatatct ttccaaaact
     8941 gtattgcttt ctccgtcaaa tttctgacag gaaaatactg ttctttagca agcagcaaac
     9001 gaatgtcacc aatatacggc tcaggctcgt atttagcacc ttttgaacta tgtataaatg
     9061 cattcaacat actttttacc atatcattag gtattctctt gccatataat cgtaacaaag
     9121 tatccgcata catacttatt tttttagttt catctaatgt ttttaattta tctagtaact
     9181 tctttaatct attatccgct ttatcatctc cctctaataa aagtatcatt tcattcataa
     9241 tttcagttgt tgaaaggtct gtaagtccca tatctttaaa actaatatta agaaaggccg
     9301 gaaacattaa ctccaaatac gaatcatctg gcacattgga catcagcggt acgctatcaa
     9361 ttaaaaccac atctacaatc ttaatcccct tttcacttaa tatacgtgca acctcaactg
     9421 caatccttcc gccaatacaa tgaccaacca attgtacctt ctttattcct cgcttttgaa
     9481 tataagctgc atactctaat gaaattgctt gataaagatt ttccggggag attttacagt
     9541 atttaaagga atcctttatt gcaaaaccaa taacttctat ttgttcccca cactgaagat
     9601 actttactaa atttctgtaa ttgtccaatg tgcctaaccc accatgaaat agaacacacg
     9661 ctgtttcttc ttctgattct atatatcgga tcacttcata attattcttt ttatcatctc
     9721 catcatccgc attctttgtt ccatatgtat ctacaaattc ttcaaatttt tctaaagttg
     9781 attgatttaa caactgacgt aaaattacat cataaggaat atccatcccc tgttcttcat
     9841 ttaaaaactg cataattttc ccagctattt gagcaataat caacgaatcg gctccatact
     9901 cataaaaact acgattccat tctatagcat caactcccaa actatcttta aatatctttt
     9961 caattttttt ctgttcttca cttcgttcat cacttataat ttcttcttgt tgagagttac
    10021 ttccaaattg tccaatatca ctccaccttt ctaaaactct cctatctatt tttcgatttg
    10081 cagtcagggg caaactatca atgacttgca tgttggaagg gatcatatat cctgcaagtt
    10141 ccttttttaa cccatcttta atttcatcta aatcataatg tggcatttgc ttttttactt
    10201 gtttggcaaa taagcgaatt ccaaacgagt cgattgaact cccttgttct ggccatgaat
    10261 acatatcccc ctctcctatt tccattaaaa gttttatcca atcactttgt ccaagataac
    10321 tggtattttt ccgcaaatca tcttgtggtt cctgcatcaa aaatgcttga gacgcaagta
    10381 tccatgctgg ttcaatcaca gattcactta ataccagcca tcctttgggg gcaatcagtt
    10441 cctttagcat ctgcatggta tatggaatat tttttgcatt ttcgactact tccacagcta
    10501 taatcatgtc aaacatattt ggaagtaagc cctgctttct ataatcttca tcaatattgt
    10561 atataccaaa tttaatattc ggatgctgat atttcgcctt tgctgttgta ataaaaaatg
    10621 aggaaacatc actaaaataa tattctatat tagatttttc taatatacct gatatttttt
    10681 ctaatacagc gcctgttcct gcaccaatct ctaaaatacg gattgtcctt tcattattgt
    10741 aggaaagcat attttgaatt aattcctcaa tacatgaatt aatataatgt gatactttac
    10801 tattgatata aaggtctctt acaatcttcc attctccata aggatacaaa atatcaactg
    10861 gatttacctt tccagaaagc aatccactaa tttgctttaa attttcctcg atataaagga
    10921 tgaaggtttc aggcattatc tcgttattcc aagtcgaata caaagactct ctataaatct
    10981 ttactttctc attaatatta tcagatttaa gttcataaac atcttcattc gttgaaacta
    11041 attttccaca ctcgcacagc ttgtctaacc atcttttaat aagccagtga tattcggatt
    11101 ttattgactc tttttgtttc ataagcgaaa aatcaatctt tttattctgt gtaagatgat
    11161 tttctttcaa atattcaagt atagaataca aaacatactc ctctaaaatt gagtttgcca
    11221 gagcaatctt ttctgcttcg tattctgcaa aaatatcatt atacaattcc ttgatctgcg
    11281 tttgtgttat attactcaat tgaaatgtat ttatgctttc tgcatcatcc tgcaatttta
    11341 taaaagcatt aagtgtagcc tccgcgcctg ctttatttat aaccactgcc gcttgtttga
    11401 ctaatggatt cttttgcaga gctgcttcta cctctcctaa ttcaatacgg tatcctcgca
    11461 attttacctg ctcatctctt cgaccttgaa aaataatatc tccagattct ttataatacc
    11521 catagtcacc agtcttatat aatcgctcat tttctgtata atcaataaaa tgagaactag
    11581 ttgtatatgt atcattataa taacagtccg ctagactttg accaccaata tacagttcac
    11641 cacttacata taacggacac atacgcattt tcttatcaag aattttgaag tactgattac
    11701 tcaaaggttt tccataagga acacttccca aactatcatc aatctcctca cataagtaat
    11761 aattagatag gcgtttgcga aacgccacaa gccgcataaa tacggcattt tttgttacct
    11821 ataaacaaat aactcctcac cgga
//
