LOCUS       c00029_gnlPro..        14390 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NHEHCBFB_29.
ACCESSION   c00029_gnlPro..
VERSION     c00029_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 14:20:15
            Original ID  :: gnl|Prokka|NHEHCBFB_29
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 23589
            Orig. end    :: 37979
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14390
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[33589:37834](-)"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      complement(10001..14245)
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..14390
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14390
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             422..946
                     /locus_tag="ctg29_23"
                     /transl_table=11
                     /translation="MNHIVIIGFMGSGKTRVGKRLAKDFNLPFVDVDRVVSKKMNLTMK
                     EIFDRFGEPFYRALETTVIKALIDDPEQKIISLGSGLPMQEQNAKYIKKLGTVVYLKGS
                     YATLKKRLENSSSNPLIEGEDKEDKIRKLLKQRDPVYTKFADVEMITGDKPFEDLIGQL
                     EEKLKTCVKNS"
     CDS             1090..1647
                     /locus_tag="ctg29_24"
                     /transl_table=11
                     /translation="MISAGDFKNGITLEIDGNVCQIVEFQHVKPGKGAAFVRTKYKNII
                     TGAVLEKSFRPTEKFPAARIERVDMQYLYDDGDLYYFMNVETYDQVGLTKDQVGDSLKF
                     VKENEMVKICSHNGNVFAIEPPLFVELEVTETEPGFAGNTAQGATKPATVETGAQVQVP
                     LFVNQGDKLKIDTRTGEYLSRV"
     CDS             1760..2767
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_17"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg29_25"
                     /sec_met_domain="Fer4_17 (E-value: 1.5e-12, bitscore: 39.1,
                     seeds: 82, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 0.00036, bitscore: 12.3,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYVTLGKTGLRVSRMGLGGIPIQKIDAEGTKTLLHKLADRGVNY
                     IDTARGYTVSEEYLGYALEGIRDRFIIATKSMARTKEAMAEDIEKSLHNLRTDHIELYQ
                     VHNPSMEQLDQVQAAGGALEALQEARAAGKIGHIGLTAHSVEVFARALELDWVETIMFP
                     YNIVESQGEELISKCEEKNIGFIDMKPLAGGAIENGTLALRYVCSNKNVTIVIPGMAEE
                     REIEENIKACLDDSPLSEKELEEVQTVRNQLGTNFCRRCNYCAPCSVGIDISGVFLFAG
                     YLNRYGLGDWARNRYSSLAVKASACIECGKCETRCPYHLPIREMLKECAQQFGE"
     CDS             2796..3041
                     /locus_tag="ctg29_26"
                     /transl_table=11
                     /translation="MFFMDLAGIEPASESLFIEASPITVAVLTFPWMYAHRQAYNLSSF
                     MIHLPGQSLPGKVSHMVDVRFLKCECIRADEQQLGC"
     CDS             3558..4238
                     /locus_tag="ctg29_27"
                     /transl_table=11
                     /translation="MDTLKILVVDDESRMRKLVKDFLTKKNFQVLEAGNGEEAMDIFYE
                     EKDIALIILDVMMPKMDGWEVCREIRKNSKVPIIMLTARSDERDELLGFDLGVDEYISK
                     PFSPKILVARVEAILRRTGQNNPEDVISAGGIVIDKAAHLATVDGKPMELSFKEFELLT
                     YFLENQGIALSREKILNSVWNYDYFGDARTIDTHVKKLRSKMGDKGEYIKTVWGMGYKF
                     EVDE"
     CDS             4235..5779
                     /locus_tag="ctg29_28"
                     /transl_table=11
                     /translation="MTGNGKTDKKFHTLQHQISVVFICLLLLSIFTITLINGLFLEKYY
                     VSKKVEVLEEAKEVLSQMNLDDILQYDTDIEEDKKGATDEISDEIERSSSRNNLTWIIV
                     NEENSGYYYWGENNMAKMLRSKLFGYINNLDQDMQHSRVLKKTDTCTMWQVHDRFAGME
                     YVECWGQFDNGYYFLIRSPLESIKESASISNSFYFIVGIIIIVVSGIVILVMTNRITRP
                     ISELTKLSEKMSDLDFDARYQSRAGNEIDVLGDNFNKMSRKLESTISELKSANNKLQKD
                     IEDKIKIDEMRKEFLDNVSHELKTPIALIQGYAEGLNENISDDPESREFYCEVIMDEAS
                     KMNKLVKNLLTLNQLESGKDAPVMERFDIVSLIRGVLGSMHIMIEQKEATVIFEETEPV
                     YVWADEFKIEEVVTNYTSNALNHLEGERKVEIKVLQEEDCVKVTVFNTGTPIPEEDIPN
                     LWNKFYKVDKARTREYGGSGIGLSIVKAIIESMNQKYGVCNYDNGVEFWFTLDCRQ"
     CDS             5999..6637
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg29_29"
                     /sec_met_domain="GATase (E-value: 2.5e-30, bitscore: 96.7,
                     seeds: 97, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIAIIDYDAGNIKSVEKALHYLGEETTVTRDPQTLLNADKVILPG
                     VGSFGQAMENLHTYGLVPVIHEIVEKKTPFLGICLGLQLLFESSEETPGVEGLGILKGK
                     IVKIPPAPGLKIPHMGWNSLHFQNNGRLFQGISEQTYVYFVHSYYLQAEEPEIVKATTE
                     YSTCIHASVEKDNVFACQFHPEKSSKWGLKILENFAAVGKDGNTEKEGK"
     CDS             6639..7397
                     /locus_tag="ctg29_30"
                     /transl_table=11
                     /translation="MFTKRIIPCLDVNNGRVVKGVNFVQLRDAGDPVEIAKAYDAAGAD
                     ELVFLDITASCEQRDTVVDMVRRVAANVFIPFTVGGGIRTVDDFKKLLREGADKISVNS
                     AAIDRPELISEAADKFGSQCVVVAIDAKRREDGGWNIYKHGGRLDTGIDAIEWAKKVEA
                     LGAGEILLTSMDCDGTKAGYDLALTRAIADAVSIPVIASGGAGTLEHFYDALTEGGADA
                     ALAASLFHYKELEISQVKDYLSDRGISVRR"
     CDS             7430..8104
                     /locus_tag="ctg29_31"
                     /transl_table=11
                     /translation="MSAISGDWLEALKGEFHQPYYAKLYKTVMTEYQTRKIFPPADDLF
                     NAFHFTPLNEVKVVILGQDPYHNDGQAHGLCFSVKRGVETPPSLVNIYQELHDDCGCYI
                     PNNGYLEKWAKQGVLLLNTVLTVRAHQANSHRGIGWEQFTDAAIQVLNEQDRPIVFLLW
                     GRPAQMKKSMLNNPKHLILEAPHPSPLSAYRGFFGCKHFSKTNEFLVANGLEPIDWQIE
                     NI"
     CDS             8150..9778
                     /locus_tag="ctg29_32"
                     /transl_table=11
                     /translation="MNQKNNLVKNASFLMIAAMISKVIGLLYKSPLSNIIGSLGMGYTS
                     LAQNAYMILLMIASFSIPQAVSKLISERIALKDYRNAHKFFKGAMIYAMVIGGVVGLFC
                     LFGAGLIIPQNQKDAIPALQILAPTIFLSGILGVFRGYFQAYRNMMPTSISQIIEQVFN
                     AAVSLLAAWGFINAFSDGIENSIAKWGAAGSTVGTGAGVVTALAFMLLVYGVNRRKILH
                     RVEKDHRHQEESYKEIFRVIILVVSPIILSAFVYNVNAYINGYLFSDILGRRGGDAAQI
                     GILYAEYATYFMTIINIPLTLSSTAPTSMIPEVSALYATGDIEATRECIDQTVQLSMVV
                     SAPCAMGLAVLAQPIVFLLYGNSTGLAANLLILGSFSILLNGMSNISNGVLQAIGQQRI
                     PVITAAIALVVDIVVVVVLLFTTNLGVYALLIAMVIYSVVVCVLNDRAMKKYLQYKNPW
                     KEGYLYPVLASVPMGIVAGCICYGLNIFVKSNFICLIVSIPVAAVVYLFAYLIISKPSE
                     SQLRRIPGGSYLIRIAEKLPFWQNN"
     CDS             complement(10001..14245)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg29_33"
                     /sec_met_domain="HGD-D (E-value: 1.2e-63, bitscore: 206.9,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 2.7e-37, bitscore:
                     119.7, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNYKTLGIDIGSTTVKIAILDENENLIFADYKRHFANIQETLADL
                     LQEAFDQYGEMTLHPVITGSGGLTLANHLGVPFTQEVIAVSTSLQKLAPKTDVAIELGG
                     EDAKIIYFENGNVEQRMNGICAGGTGSFIDQMASLLQTDATGLNEYAKDYKALYPIAAR
                     CGVFAKTDIQPLINDGATKPDLSASIFQAVVNQTISGLACGKPIRGHVAFLGGPLHFLS
                     ELRESFIRTLKLDEEHTIIPENSHLFAAIGSALNAKEDNSISLTEMKDRLRNSIKLDFE
                     VERMEPLFASQEEYDTFAKRQSSYKVKTGDLATYKGNCYLGIDAGSTTTKTALVGEDGT
                     LLYSFYSSNNGNPLKTTIRSIKEIYELLPENAKIAYSCSTGYGEALIKAALILDEGEVE
                     TVSHYYAAAFFDPEVDCILDIGGQDMKCIKIRNKTVDSVQLNEACSSGCGSFIETFAKS
                     LNYTVQDFAKAAVFAQHPIDLGTRCTVFMNSKVKQAQKEGAEVSDISAGLAYSVIKNAL
                     YKVIKVSDASELGKHIVVQGGTFYNDAVLRSFEKIAGCEAIRPDIAGIMGAFGAALIAR
                     ERHQEGAETTMLSIDKINELKYTTSMANCRGCTNNCRLTINKFSGGRQYVSGNRCERGI
                     GKEKNKDHIPNLYEYKYKRIFSYAPLTADKATRGKVGIPRVLNMFENYPFWYTFFTELK
                     YEVVLSPTSTRKIYELGIESIPSESECYPAKLAHGHVTWLIRNGVKFIFYPCIPYERNE
                     FPDAVNHYNCPIVTSYAENIKNNVDELNDPSITFRNPFLAFTSEEILANRLVEEFKDIP
                     AGEVKAAVHKGWEEMAAARRDVQKKGEETLKYLEDTGRHGIVLAGRPYHIDPEIHHGIP
                     DLINSYGIAVLTEDSISHLAPVERPIRVNDQWMYHSRLYAAANYVKTRDDLDLIQLNSF
                     GCGLDAVTTDEVYEILDGSDKIYTCLKIDEVNNLGAARIRIRSLIAAIRAKKAQGQKRT
                     VKPASIDKVSFTKEMRKEYTILCPQMSPFHFSLLQAAFNSCGYNLEVLPNDNKHAVDVG
                     LKYVNNDACYPSLIVVGQIMDALLSGKYDLNKTAVVMSQTGGGCRASNYIAFIRRALKK
                     AGMEQIPVISVNLSGLESNPGFKLTLPLVKKVAYGAVFGDILMKCVYRMRPYELEEGIV
                     NRKHKIWEQRVISFLSGSSISHSQFKKMCCEMVHEFDTIPISDVKKPRVGIVGEILVKF
                     LPAANNHLAELLESEGAEAVVPDLIDFMCYCFYNQNFKVENLGFKKSKATMANWGIKAI
                     EWVRKPASEALAQSRHFAPPADIRDLAKMASPIVSTGNQTGEGWFLTGEMMELIHGDVP
                     NIVCIQPFGCLPNHIVGKGVIKEIRREYPTANIVAIDYDPGASEVNQLNRIKLMLSTAQ
                     KNLKKVEEKMHK"
ORIGIN
        1 acagaggact tctgtttgat atagataata ctctggtacc tcatggtgca ccggcagatg
       61 agagagcatg tgcgttgttt gcacatctga aggaacttgg atttaaatgc tgttttctgt
      121 caaacaacca gtacgagaga gtttcttctt ttaatgatgc gataggagcg cagtttatcg
      181 agaatgcaca caagccttca acaaaaaatt atatcagggc aatggaactt cttgggacag
      241 acagaagtaa tacagttttt ataggagatc agctctttac tgatatatat ggtgcgaaac
      301 gcacaggaat ccggaatatt ctggtgaaac cactcaatcc gaaagaagag attcagattg
      361 tactgaaacg atatcttgaa agaattgtac tatattttta ccgcaaagag gaggggaatt
      421 catgaaccat attgttatca taggatttat gggttcaggt aagacaagag taggaaaacg
      481 gctggcaaaa gatttcaatc ttccttttgt agacgttgac cgcgtagtat caaagaagat
      541 gaaccttaca atgaaagaaa tctttgacag attcggagaa ccattttaca gagctcttga
      601 gacaactgtg atcaaggcac tgatcgatga tccggaacag aagatcattt ctctggggtc
      661 cggtcttccg atgcaggaac agaatgcaaa atatattaaa aaactgggaa ctgtagtata
      721 tttgaaggga tcttatgcaa cgttgaagaa gagactggaa aattccagca gcaatcctct
      781 gatcgaggga gaagacaaag aagataagat cagaaaactt cttaaacagc gcgatccggt
      841 ttatacaaag tttgcagatg ttgagatgat cacaggagac aagccatttg aggatctgat
      901 tggtcagctt gaagaaaaat taaaaacatg tgtaaaaaat agttgaaaaa aacagcagaa
      961 tattataaaa ttaaataaga gtgtgtcaca aaactgagaa aagcatgaga gggacacaca
     1021 ctttgaacgg ctgttgttgt caaaagacac agcattgctg aactgtacta ttaaggagga
     1081 aatataacta tgatttcagc aggtgatttc aaaaacggta tcacacttga aattgacgga
     1141 aacgtatgtc agattgttga attccagcac gtaaaaccag gaaagggtgc tgctttcgta
     1201 agaacaaaat acaaaaacat tattacagga gcagttcttg agaaatcttt ccgtccaaca
     1261 gagaaattcc cggctgcacg tattgagcgt gtagatatgc agtatctgta tgatgatggt
     1321 gatctgtact actttatgaa cgtagagaca tacgatcagg ttggtcttac aaaagatcag
     1381 gttggagatt ctcttaaatt cgttaaagag aacgagatgg ttaagatctg ttcccacaac
     1441 ggaaatgtat ttgctattga gcctcctctg ttcgtagaac ttgaagttac tgagacagag
     1501 ccgggattcg ccggaaatac agcacagggt gccacaaaac cggctactgt agagacaggt
     1561 gcacaggttc aggttccgct gtttgttaac cagggcgata aactgaaaat tgatacaaga
     1621 acaggagaat atctttctcg agtataatca ggatgaaacc agttgttttt tctgattaac
     1681 agttgtaaag agataatcag actgccatcg gtaagatccg gtggcagttt ttatctttga
     1741 ttggaatagg agaaaaaata tggaatacgt aacacttgga aaaaccggtc tcagggtttc
     1801 cagaatgggc cttggcggga taccgatcca gaaaattgat gcggaaggaa caaagacact
     1861 gctgcataag ctagcagacc ggggagtaaa ttatattgat acagccagag gatatacggt
     1921 cagtgaagaa tatctgggat atgcactgga aggtatcagg gacagattta taattgccac
     1981 aaagtccatg gcacgtacaa aggaagccat ggctgaagat attgagaaga gtcttcataa
     2041 tcttcgtaca gatcatattg aattatacca ggtgcataat ccgagtatgg aacagcttga
     2101 tcaggtgcag gcggccggtg gtgcccttga agcactgcag gaggcaagag cagcaggaaa
     2161 aatcggacat attggtctga ccgctcattc tgtggaggtt tttgcccggg ctctggagct
     2221 tgactgggtg gaaactatta tgtttccata taatattgta gagagtcagg gggaagagct
     2281 gatctcaaaa tgtgaggaga aaaacatcgg ctttattgat atgaaacctc tggccggtgg
     2341 tgcaattgaa aatggaacgc tggcattgcg ttatgtctgt tcgaataaga acgttactat
     2401 tgtgatcccg ggaatggcgg aagagaggga aatcgaggag aatataaagg cctgtcttga
     2461 tgattctccg ttaagcgaga aagaactgga ggaagttcag acagtacgga atcagcttgg
     2521 aacaaatttc tgccgcagat gtaattactg tgctccatgc agtgtgggaa tcgatatttc
     2581 gggtgtgttc ctgttcgcag gctatcttaa ccgttacggg ctgggagact gggcaagaaa
     2641 ccgttacagt tctcttgcgg tgaaggcttc cgcctgtata gaatgcggca aatgtgaaac
     2701 cagatgtccg taccatctgc caatccgcga aatgctgaaa gaatgtgcac aacagtttgg
     2761 tgaataaaaa acatccacag ggaattaccc tgtggatgtt ttttatggac ctggcgggaa
     2821 ttgaacccgc gtccgaaagc ctattcattg aggcatctcc catcacagtc gctgttttaa
     2881 cattcccttg gatgtacgcc caccgacagg cttacaacct tagtagcttc atgatacatc
     2941 taccggggca aagcttaccc ggcaaggttt ctcacatggt cgacgtcaga ttcctgaagt
     3001 gtgagtgcat cagggctgac gagcagcaat taggctgcta acgcgtactg ttcgtctgcg
     3061 tttatattta gtttcccggt tggtacgcag tctgggagtc tgcggatggc ttccccaact
     3121 tcaaagcccc cgtcgaaacc agtacaagcc ctgaaaatga gtctgcaacg ctgttttttc
     3181 ataaaatagc actggtgatg agacgaaagc actttttaat attgatatat cattcattat
     3241 ataagatata tcgactgatt aacagtatag aaataaaaac agaatttgtc aagaagattt
     3301 ttatatttgg gcctgcttgg tgttgtgaac agcaatactt ataatttttc tgtcatatgt
     3361 tcacaaatct tacataaatc tctgttatag taaccatatg aaagataaaa tctgttgctg
     3421 agggcgattt tcccggattt tgcgctgtgg ctgtaaaggc gctgaacagt cgtggatttt
     3481 aacaatactc ggaaaacagt ataaataaaa agtaaaaact gtttcggaaa ataatgaaga
     3541 aaaacggagg ggatcaaatg gatacattaa aaatcctggt ggtggatgat gagagccgca
     3601 tgagaaagct ggtaaaggat ttcctgacaa agaagaattt ccaggtactg gaagccggta
     3661 atggtgaaga agccatggat atcttttatg aggagaagga catcgcactg atcattttgg
     3721 atgtcatgat gccgaagatg gatggatggg aagtttgccg tgagattcgc aagaactcaa
     3781 aagttccgat tattatgctg actgcaagaa gtgatgagag agatgagctt cttggatttg
     3841 atctgggggt agatgaatac atctctaaac cattcagtcc gaaaatcctt gttgcaagag
     3901 tggaggcaat tctgagacgt acaggtcaga ataatccgga agatgtgatt tcagcaggcg
     3961 gcattgttat agataaagca gcacatctgg ctactgtgga tggtaagcct atggaactga
     4021 gctttaagga atttgaactt ctgacatatt ttctggagaa tcagggaatc gcactttcca
     4081 gagaaaagat cctgaattct gtatggaatt atgactactt tggagatgcc cgtacgattg
     4141 atacccatgt taagaagctc agaagtaaaa tgggagataa aggtgaatat ataaagactg
     4201 tatggggtat gggatacaag tttgaggtag acgaatgaca ggaaacggaa aaacagataa
     4261 aaaatttcat actctgcaac atcagatttc agtagtgttt atatgtctgt tactgctttc
     4321 gatctttacc attactctga tcaatggtct ttttcttgaa aaatattatg tatccaaaaa
     4381 agtagaagtg ctggaggagg caaaagaagt gttgtctcag atgaatctgg atgacatcct
     4441 gcagtatgat acagatatag aagaggacaa aaaaggggca acagatgaga tttcggatga
     4501 gattgagagg agcagttcca gaaataacct tacctggatc atagtaaatg aggaaaacag
     4561 tggttattat tactggggag agaataatat ggcaaaaatg ctccgcagta agctgtttgg
     4621 gtatattaat aatctggatc aggatatgca gcacagtcgt gtgctcaaaa agacagatac
     4681 ctgtaccatg tggcaggtgc atgatcgctt tgcaggcatg gaatatgtgg aatgctgggg
     4741 acagtttgat aatggttact atttcctgat tcgttctcct ctggaaagta ttaaggaaag
     4801 tgcatctatt tccaacagtt tttacttcat tgtaggaata atcataattg tggtcagcgg
     4861 tattgtgatt cttgtgatga caaatcgtat tacccgcccg atcagtgaac tgaccaaatt
     4921 atcagagaag atgtctgatc tggattttga tgccagatat caaagcaggg caggtaatga
     4981 gattgatgta cttggcgata actttaacaa aatgtccaga aaacttgaga gcacgatctc
     5041 agagttgaaa tcggctaata acaagcttca gaaagacata gaagataaga ttaaaattga
     5101 tgagatgcgt aaggaatttc ttgataatgt ttctcatgag ctgaaaactc ctattgcatt
     5161 gatccaggga tatgcagagg ggctgaatga aaatatttcc gatgatccgg aaagcaggga
     5221 attttactgt gaagttatta tggatgaggc ttcaaagatg aacaagctgg tcaaaaacct
     5281 gctgacgctg aatcagctgg agtccggtaa agatgccccg gtgatggaaa gatttgacat
     5341 tgtatccctg atcaggggtg tacttggttc tatgcatatt atgatcgaac agaaagaagc
     5401 aactgtgatt tttgaagaaa cagaacctgt atatgtatgg gcggatgagt ttaagattga
     5461 agaggttgtg accaattata caagcaatgc actgaaccat ctggaaggag aacgaaaagt
     5521 agaaattaag gttcttcagg aagaggactg tgtgaaagta accgtattta atacaggtac
     5581 tccgattccg gaagaggata tcccaaatct ctggaataaa ttctacaaag tagataaggc
     5641 ccggacaaga gaatatggcg gaagtggtat cggactttca attgttaagg caatcattga
     5701 gagtatgaac cagaaatatg gggtatgcaa ttatgataat ggcgtggagt tctggttcac
     5761 tctggattgc aggcagtgat aagatatccg ggtattgtga acggagtgaa cagtaaccgg
     5821 tagtatgacc ggaataaaaa cagacagaag caaagaaagc actttgcaac tgtctgtttt
     5881 tgggttatac tgtattggag cgttttgatc ggatatttta ttccggtctg acatgtgatc
     5941 cggaaaacct ttggattacc ataatgagga aaacagataa tgacatcagg aggataacat
     6001 gattgcaata attgactatg atgccggaaa tattaaaagt gtagaaaaag cacttcatta
     6061 tcttggggaa gaaacaacag taacccgcga tccgcagact ttgttaaatg cggataaagt
     6121 aatcctgccg ggcgtgggaa gctttggaca ggcgatggag aatcttcata catacggact
     6181 tgtacctgtg atccatgaga ttgtagagaa gaagacgcca tttcttggaa tctgcctggg
     6241 acttcagctc ctttttgaaa gcagcgagga gacaccgggg gtggaaggcc ttggaatcct
     6301 gaaagggaaa attgttaaga ttcctcctgc gccggggctt aagattccac atatgggatg
     6361 gaattccctg cattttcaga ataatggcag actgtttcag ggaatctcgg aacagaccta
     6421 tgtatatttt gtgcattcct attatctgca ggcagaggag cctgagattg taaaggctac
     6481 tacagaatac agcacctgta ttcatgcttc cgtagaaaag gacaatgtat ttgcctgcca
     6541 gttccatccg gaaaagagca gcaaatgggg actgaagata cttgaaaatt ttgctgctgt
     6601 gggaaaagac ggcaatactg agaaggaggg aaaataaaat gtttacaaag agaattattc
     6661 cctgcctgga tgtaaataac ggacgtgtgg taaagggcgt aaattttgtg cagcttcgcg
     6721 atgcgggtga tccggtggag attgccaaag cctatgatgc agcaggagca gatgaactgg
     6781 tgtttctcga tattacagca tcctgcgaac agagagatac ggtagttgac atggtaagac
     6841 gggttgctgc caatgtattt atcccgttta cagtaggcgg cggtatccgt actgtagatg
     6901 atttcaagaa actgctgaga gaaggagcag ataagatttc cgtaaattct gcagcaattg
     6961 acagaccgga actgatcagt gaggcggctg acaagtttgg aagccagtgc gtagttgtgg
     7021 ctattgatgc caagcgcaga gaagacggcg gatggaatat ttacaaacat ggcggaagac
     7081 tggatacagg gattgatgcc atagagtggg caaagaaagt ggaagctttg ggcgcagggg
     7141 aaatccttct taccagtatg gactgtgacg gtacaaaagc aggatatgat ctggctctta
     7201 ccagagcaat cgctgatgct gtctccattc ctgtgatcgc atcaggcggt gcaggtacac
     7261 tggagcattt ttatgatgca ctgaccgaag ggggagcaga tgctgcactg gctgcgtctt
     7321 tgtttcatta taaagaactg gagatttctc aggtgaagga ttatctgtct gacaggggaa
     7381 tttctgtcag acgatgacca cgaagaatat aagaggtgaa ggataaggta tgtcagcaat
     7441 ttcaggtgac tggctggaag ccctgaaggg ggagtttcac cagccgtatt atgcgaaatt
     7501 atataaaacg gtgatgacag aatatcagac taggaagatt tttcctcctg cggatgatct
     7561 gtttaatgca tttcatttta caccgttaaa tgaagtgaag gtagtgatcc tgggtcagga
     7621 tccctatcat aatgacgggc aggctcatgg gctttgtttt tccgtaaaga gaggagtgga
     7681 gactccgccg tccctggtga atatttatca ggagcttcat gatgactgtg gatgctatat
     7741 ccccaataac ggctatctgg agaagtgggc gaagcagggg gtgcttcttc tgaacacagt
     7801 tctgactgta cgcgcccatc aggcaaattc acacaggggg atcggctggg agcagtttac
     7861 ggatgctgcg atccaggttc tgaatgagca ggaccgtcct attgtatttc tgctctgggg
     7921 acgtccggcg cagatgaaaa aatccatgtt gaataatccg aagcatctga ttctggaggc
     7981 accgcatcca agtcctctgt ctgcttacag gggatttttc ggatgtaaac atttcagtaa
     8041 aacaaacgaa tttcttgttg ccaatggtct ggaaccaatc gactggcaga tagaaaatat
     8101 ataagaaaag aggtaatgtg tagtcaggta aaagacacac agtgataaca tgaatcagaa
     8161 aaacaattta gtaaaaaatg catcctttct gatgattgca gctatgatct ccaaggtgat
     8221 cggtcttctg tacaagagtc ccctttccaa tattatcgga agccttggaa tgggctatac
     8281 aagtcttgca cagaatgcct atatgatcct tctgatgatc gcatccttta gtattccaca
     8341 ggcggtatcc aagctgatct ccgagcgtat tgctctgaag gattacagaa atgcacataa
     8401 gttctttaag ggtgccatga tctatgccat ggtgattggc ggagtggtcg gtttattctg
     8461 tctctttgga gcagggttga tcatccctca gaatcagaag gatgcaattc cggcacttca
     8521 gatcctggct ccgacgattt ttttgtccgg tattcttggg gtattcagag gatattttca
     8581 ggcatacaga aatatgatgc caacatctat ctcccagatc attgagcagg tatttaatgc
     8641 ggcagtcagt cttctggcag cctggggatt catcaatgca ttctcagatg gaatagagaa
     8701 cagcattgca aaatgggggg cagcaggttc cacagtagga accggagccg gagtggtgac
     8761 tgcattggca ttcatgcttc tggtgtatgg tgtaaaccgc agaaaaatcc tgcaccgggt
     8821 agagaaagac cacagacatc aggaagagtc ctacaaagag atttttcgtg tgattatcct
     8881 ggttgtttcg ccgatcattc tcagcgcctt tgtttataat gtaaatgctt atatcaatgg
     8941 gtatcttttc tcggatattc tgggaagaag aggtggagat gcggcacaga ttggtatttt
     9001 atatgcagag tatgctactt actttatgac aattattaat attcctctga cgctgtccag
     9061 tacggcacct acttccatga ttccggaagt ttccgccctg tatgccaccg gagacattga
     9121 agcgactaga gagtgcattg accagaccgt acagctttct atggtagttt ctgccccatg
     9181 tgccatggga ctggcagtgc ttgcacagcc gattgtattt ttgctttacg gaaattccac
     9241 aggactggca gccaacctgc tgatccttgg ttctttttcg atcctgctca atggaatgtc
     9301 aaatatttcc aatggagttc tgcaggcaat cggacagcag aggattccgg tgattacggc
     9361 tgcaatcgca ctggttgtgg atattgtggt agtggtagtg ctgctgttta ctacaaacct
     9421 tggagtttat gcactgctga tcgcaatggt gatctattct gtggttgtat gtgtgttaaa
     9481 tgacagagcc atgaagaaat atctgcagta taagaatcca tggaaagaag gatatctgta
     9541 tcctgttctt gcatctgttc ccatgggaat tgttgcaggc tgtatctgct atggactgaa
     9601 catttttgta aaatccaatt tcatttgtct gatcgtttcc attcctgttg ctgcggttgt
     9661 ttatctgttt gcttacctga ttatcagcaa gccgtcagaa tcacagctta gaagaattcc
     9721 gggtggaagc tatctgataa gaattgcaga gaaacttccg ttctggcaga ataattaaac
     9781 actgaaattg taaaaaacaa aagagttata tttcatggtt taaatgtagt tctgaaatag
     9841 aaacacattt aaaatttctg aaatataact ctttttttga gcgcgtttga aaaatgcttt
     9901 tcgcaaagca ggatatgtag attgcgggaa agcctttttc agacacgctc taaggcggac
     9961 atattgcaag gtaaaataca ttgcaatata tccattacgg ttatttatgc attttttctt
    10021 ctactttttt cagattcttc tgggctgtgg agagcatcag tttgattcgg ttgagctgat
    10081 tgacttcact tgcacccgga tcatagtcga tggctacaat attggctgtc ggatattctc
    10141 tgcggatctc tttgataaca cccttaccta caatgtggtt cggcagacat ccgaaaggct
    10201 ggatacaaac aatattcgga acatctccat ggatcagttc catcatctca cctgtcagga
    10261 accatccctc acctgtctgg tttccggtgg aaacgatcgg agatgccatt tttgccagat
    10321 ctctgatatc agcaggcggt gcaaaatggc ggctctgtgc aagagcttcg cttgcaggct
    10381 ttctcaccca ttcgattgct ttgattcccc agtttgccat ggttgccttg gacttcttga
    10441 atccaagatt ttctacctta aagttctgat tatagaagca gtagcacatg aaatcgatca
    10501 gatccggtac aactgcctca gcaccttcag attccagaag ctctgccaga tgattatttg
    10561 cagcaggcag gaacttgaca aggatctcac ctacgatgcc gacacgaggc tttttcacat
    10621 cactgatcgg aatggtatca aattcatgaa ccatttcgca gcacattttc ttaaactggc
    10681 tgtggctgat actgcttccg cttaagaaag agatcacacg ctgttcccag attttatgtt
    10741 tcctgtttac gattccctct tccagttcat aaggacgcat acgatatacg catttcatca
    10801 ggatatctcc gaatacggca ccgtaagcaa ctttcttcac taatggaagc gtaagtttga
    10861 atccgggatt gctttccaga ccgcttaagt taacagagat aaccggaatc tgttccatac
    10921 cggctttctt taatgcgcgt cgtataaatg caatatagtt ggaagcacga catccgccac
    10981 ctgtctgtga catgacaacg gccgttttgt tcaggtcata tttaccggaa agtagagcat
    11041 ccatgatctg tcccacaacg atcagagacg gatagcaggc gtcattgttt acatacttca
    11101 gaccaacatc cactgcatgc ttattgtcat tcggaagcac ctccaggttg tatccgcagg
    11161 aattgaatgc tgcctgcagg aggctgaaat ggaacggtga catctgcggg cagaggatgg
    11221 tatattcctt tctcatttcc tttgtaaagg atactttatc aatggaagca ggtttgacag
    11281 tacgtttctg tccttgtgct ttcttcgcgc ggatcgctgc gatcagggaa cggatacgga
    11341 ttcttgcagc accaaggtta tttacctcgt caatctttaa gcaggtatag attttgtcac
    11401 ttccgtcaag gatttcataa acctcgtctg tagtaactgc atccagacca catccaaaag
    11461 agttgagctg gatcagatcc aggtcatcgc gtgtctttac atagtttgcg gcagcataca
    11521 gtctggagtg gtacatccac tggtcgttga cgcggatcgg gcgttccaca ggtgccagat
    11581 gagagatgga atcctcagta agtacggcaa taccatagct gttgatcaga tccgggatac
    11641 catgatggat ttccgggtca atatggtatg ggcgtcctgc aaggacaata ccatggcgtc
    11701 ctgtatcttc cagatatttc agggtttctt cccctttttt ctgtacatcg cggcgtgcag
    11761 cagccatttc ctcccagccc ttatgcacag cagctttgac ttctcctgcc gggatatcct
    11821 taaattcctc taccagacga tttgccagaa tttcctcaga agtaaatgca aggaagggat
    11881 tgcggaaggt aatagacgga tcatttaatt cgtctacgtt atttttgata ttttcggcat
    11941 aagaggtaac gatcgggcag ttatagtgat tgactgcatc cgggaactcg ttacgttcat
    12001 atgggataca tgggtagaaa ataaatttca cgccattgcg gatcagccag gttacatggc
    12061 catgggcaag tttggcagga tagcattcag attcacttgg aatggactca atacccagct
    12121 cataaatctt tctggtggaa gtaggagaga gcacaacctc atacttcagt tctgtaaaga
    12181 aagtatacca gaaaggataa ttctcaaaca tgttcagaac acgggggata cctactttac
    12241 ctcgcgttgc cttatcagca gtaagcggtg cgtaggagaa aatacgctta tatttatatt
    12301 cataaagatt cggaatatga tctttgttct tttccttacc gataccgcgt tcacagcggt
    12361 taccgcttac atactggcgg ccgccggaga atttgttgat agtcagacgg cagttattgg
    12421 tacatccacg acagtttgcc atagaagttg tatatttcag ctcgttgatc ttatcaatgg
    12481 agagcatagt cgtttctgcg ccttcctgat ggcgttcacg ggcaatcagt gcggcaccga
    12541 aagcacccat gattccggca atatccggac ggatggcttc gcagcctgca atcttttcga
    12601 agcttcgaag aaccgcatca ttgtagaagg taccaccctg tacaacgatg tgcttgccaa
    12661 gttcggaagc gtcagaaacc ttgataacct tatacagagc atttttgata acagagtaag
    12721 caagacctgc ggaaatatca gaaacctcag ctccctcttt ctgtgcctgc tttaccttgg
    12781 aattcatgaa aacagtacat ctggtaccaa gatctatagg atgctgtgcg aaaacagcag
    12841 cttttgcgaa atcctgcact gtataattca gggatttggc aaaggtttca ataaaggaac
    12901 cgcatccgga ggagcatgct tcatttaact gtacgctgtc aacggtctta ttgcggattt
    12961 tgatacattt catatcctgt ccgccgatat ccaggataca gtctacctct gggtcaaaga
    13021 atgcagctgc atagtaatgg gatacggtct caacctcgcc ctcatccagg atcagagcag
    13081 ccttaatcag agcctcgccg taacctgtag aacaggaata agcaatcttt gcattctcgg
    13141 gaagcagctc gtaaatctct ttaatagaac ggatggtagt ttttaacggg tttccgttgt
    13201 tgctgctgta gaaagagtag agaagtgttc cgtcttcacc taccagtgca gttttggttg
    13261 tggtggaacc tgcatcaata cccagatagc agtttccttt atatgtagcc agatctcctg
    13321 tttttacttt gtaggaactc tgacgtttcg caaatgtatc gtattcttcc tgagaagcga
    13381 aaagtggttc catacgttct acttcaaaat ccagcttaat ggaattgcgg agtctgtctt
    13441 tcatttctgt cagggaaatg gagttgtctt cttttgcatt taatgcagaa ccgatggctg
    13501 caaaaagatg ggagttctcc ggaatgatgg tgtgttcctc atccagcttc aaagtacgga
    13561 taaaggactc tctcagctcg gacaggaagt gaagcggacc acccaggaat gcaacatgtc
    13621 cacgaatggg ttttccacag gcaagaccgg aaatagtctg gtttacaact gcctggaaaa
    13681 tagaagctga cagatccggt ttggttgcac cgtcattgat cagtggctgg atatccgttt
    13741 tggcgaaaac accgcagcgt gcagcaatcg ggtagagcgc tttgtaatct ttggcatatt
    13801 cattcagacc tgtggcatct gtctggagaa gagaagccat ctggtcgatg aaagaaccgg
    13861 taccgcctgc acagataccg ttcatacgct gttctacgtt tccgttttcg aaataaatga
    13921 tcttggcatc ctcaccgcca agctcgatgg caacatctgt ctttggtgcc agcttctgca
    13981 gagaagtaga aactgcaata acctcctggg taaaaggaac gcccagatgg ttggcaaggg
    14041 tcagaccgcc ggaacctgtg atcacaggat ggagagtcat ctcgccatac tggtcaaagg
    14101 cctcctgaag aaggtctgca agggtttcct gaatgttcgc aaaatgacgc ttgtaatccg
    14161 cgaaaatgag attttcattc tcatctaaga tcgcgatctt tacagtagtg gaaccaatgt
    14221 caattccaag tgttttgtaa ttcataaagt aaattcaagc ctcctcgtat tgtatataaa
    14281 caaaattgaa attttcctgt tactgttcac acaccactat cccgcgaggt gttttggcat
    14341 gaatatgcca aaatcccgag acatacaagc caaaattcca ttgccgcagg
//
