Select genomic region:
Overview
18.1
40.1
44.1
44.2
55.1
60.1
77.1
77.2
88.1
99.1
109.1
109.2

### Identified primary metabolite regions

c00018_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_18)

Region | Type | Class | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | --- | ---
Region 18.1 | Acetyl-CoA_pathway | SCFA | 15,662 | 49,805 | Acetyl-CoA pathway B. hydrogenotrophica | Acetate | 61%

c00040_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_40)

Region | Type | Class | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | --- | ---
Region 40.1 | Rnf_complex | E-MGC | 24,621 | 49,632 | Rnf complex C. sporogenes | RNF | 100%

c00044_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_44)

Region | Type | Class | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | --- | ---
Region 44.1 | Others_HGD_unassigned | Putative | 52,913 | 73,238 |
Region 44.2 | Others_HGD_unassigned,TPP_AA_metabolism | Putative | 101,203 | 134,421 |

c00055_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_55)

Region | Type | Class | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | --- | ---
Region 55.1 | TPP_AA_metabolism | Putative | 41,688 | 70,423 |

c00060_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_60)

Region | Type | Class | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | --- | ---
Region 60.1 | Fumarate2succinate | SCFA | 5,653 | 24,186 |

c00077_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_77)

Region | Type | Class | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | --- | ---
Region 77.1 | GR_AA_metabolism,Pyruvate2acetate-formate | SCFA | 84,816 | 122,583 | Pyruvate to acetate-formate E. coli | PFL_acetate | 100%
Region 77.2 | PFOR_II_pathway | SCFA | 126,975 | 150,511 | PFOR II pathway B. thetaiotaomicron | PFORII | 100%

c00088_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_88)

Region | Type | Class | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | --- | ---
Region 88.1 | GR_eut-pdu-related | Putative | 14,421 | 50,679 | Propanediol degradation S. enterica | PDU | 37%

c00099_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_99)

Region | Type | Class | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | --- | ---
Region 99.1 | succinate2propionate | SCFA | 83,031 | 108,353 | Succinate to propionate B. theta | PRO | 33%

c00109_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_109)

Region | Type | Class | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | --- | ---
Region 109.1 | Rnf_complex | E-MGC | 1 | 25,902 | Acetyl-CoA pathway B. hydrogenotrophica | Acetate | 14%
Region 109.2 | Putrescine2spermidine | Aliphatic_amine | 66,602 | 89,850 | Putrescine2spermidine E. rectale | SPRM | 100%

Region | Type | Class | From | To | Most similar known cluster | Similarity
--- | --- | --- | --- | --- | --- | ---
Region 18.1 | Acetyl-CoA_pathway | SCFA | 15,662 | 49,805 | Acetyl-CoA pathway B. hydrogenotrophica | Acetate | 61%
Region 40.1 | Rnf_complex | E-MGC | 24,621 | 49,632 | Rnf complex C. sporogenes | RNF | 100%
Region 44.1 | Others_HGD_unassigned | Putative | 52,913 | 73,238 |
Region 44.2 | Others_HGD_unassigned,TPP_AA_metabolism | Putative | 101,203 | 134,421 |
Region 55.1 | TPP_AA_metabolism | Putative | 41,688 | 70,423 |
Region 60.1 | Fumarate2succinate | SCFA | 5,653 | 24,186 |
Region 77.1 | GR_AA_metabolism,Pyruvate2acetate-formate | SCFA | 84,816 | 122,583 | Pyruvate to acetate-formate E. coli | PFL_acetate | 100%
Region 77.2 | PFOR_II_pathway | SCFA | 126,975 | 150,511 | PFOR II pathway B. thetaiotaomicron | PFORII | 100%
Region 88.1 | GR_eut-pdu-related | Putative | 14,421 | 50,679 | Propanediol degradation S. enterica | PDU | 37%
Region 99.1 | succinate2propionate | SCFA | 83,031 | 108,353 | Succinate to propionate B. theta | PRO | 33%
Region 109.1 | Rnf_complex | E-MGC | 1 | 25,902 | Acetyl-CoA pathway B. hydrogenotrophica | Acetate | 14%
Region 109.2 | Putrescine2spermidine | Aliphatic_amine | 66,602 | 89,850 | Putrescine2spermidine E. rectale | SPRM | 100%

No primary metabolite regions were found in these records:
  c00001_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_1)
  c00002_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_2)
  c00003_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_3)
  c00004_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_4)
  c00005_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_5)
  c00006_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_6)
  c00007_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_7)
  c00008_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_8)
  c00009_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_9)
  c00010_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_10)
  c00011_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_11)
  c00012_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_12)
  c00013_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_13)
  c00014_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_14)
  c00015_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_15)
  c00016_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_16)
  c00017_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_17)
  c00019_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_19)
  c00020_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_20)
  c00021_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_21)
  c00022_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_22)
  c00023_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_23)
  c00024_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_24)
  c00025_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_25)
  c00026_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_26)
  c00027_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_27)
  c00028_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_28)
  c00029_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_29)
  c00030_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_30)
  c00031_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_31)
  c00032_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_32)
  c00033_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_33)
  c00034_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_34)
  c00035_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_35)
  c00036_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_36)
  c00037_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_37)
  c00038_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_38)
  c00039_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_39)
  c00041_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_41)
  c00042_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_42)
  c00043_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_43)
  c00045_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_45)
  c00046_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_46)
  c00047_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_47)
  c00048_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_48)
  c00049_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_49)
  c00050_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_50)
  c00051_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_51)
  c00052_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_52)
  c00053_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_53)
  c00054_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_54)
  c00056_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_56)
  c00057_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_57)
  c00058_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_58)
  c00059_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_59)
  c00061_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_61)
  c00062_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_62)
  c00063_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_63)
  c00064_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_64)
  c00065_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_65)
  c00066_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_66)
  c00067_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_67)
  c00068_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_68)
  c00069_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_69)
  c00070_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_70)
  c00071_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_71)
  c00072_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_72)
  c00073_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_73)
  c00074_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_74)
  c00075_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_75)
  c00076_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_76)
  c00078_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_78)
  c00079_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_79)
  c00080_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_80)
  c00081_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_81)
  c00082_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_82)
  c00083_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_83)
  c00084_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_84)
  c00085_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_85)
  c00086_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_86)
  c00087_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_87)
  c00089_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_89)
  c00090_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_90)
  c00091_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_91)
  c00092_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_92)
  c00093_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_93)
  c00094_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_94)
  c00095_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_95)
  c00096_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_96)
  c00097_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_97)
  c00098_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_98)
  c00100_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_100)
  c00101_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_101)
  c00102_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_102)
  c00103_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_103)
  c00104_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_104)
  c00105_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_105)
  c00106_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_106)
  c00107_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_107)
  c00108_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_108)
  c00110_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_110)
  c00111_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_111)
  c00112_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_112)
  c00113_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_113)
  c00114_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_114)
  c00115_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_115)
  c00116_gnlPro.. (original name was: gnl|Prokka|OHHHLHLN_116)

Compact view
c00018_gnlPro.. - Region 1 - Acetyl-CoA_pathway
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Download region GenBank file
Location: 15,662 - 49,805 nt. (total: 34,144 nt) Show pHMM detection rules used
Acetyl-CoA_pathway: (CdhC and CdhD and minimum(8, [CbiA, FTCD_C, FTHFS, FeS, Fer2, GCV_H, MTHFR, MTHFR_C, Prismane, Pterin_bind, Pyr_redox_2, Pyr_redox_dim, RACo_C_ter, THF_DHG_CYH, THF_DHG_CYH_C]))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
resistance genes
encapsulation genes
electron transport genes
other genes
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
KnownClusterBlast
Similar known gene clusters
Shows clusters from the gutSMASH KnownClusterBlast database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
c00040_gnlPro.. - Region 1 - Rnf_complex
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Download region GenBank file
Location: 24,621 - 49,632 nt. (total: 25,012 nt) Show pHMM detection rules used
Rnf_complex: (Complex1_51K and minimum(5, [FMN_bind, FeS, Fer4, Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N, SLBB]))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
resistance genes
encapsulation genes
electron transport genes
other genes
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
KnownClusterBlast
Similar known gene clusters
Shows clusters from the gutSMASH KnownClusterBlast database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
c00044_gnlPro.. - Region 1 - Others_HGD_unassigned
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Download region GenBank file
Location: 52,913 - 73,238 nt. (total: 20,326 nt) Show pHMM detection rules used
Others_HGD_unassigned: (minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl, Carboxyl_trans, CoA_trans, CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans, CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III, ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C, BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C, Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
resistance genes
encapsulation genes
electron transport genes
other genes
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
KnownClusterBlast
Similar known gene clusters
Shows clusters from the gutSMASH KnownClusterBlast database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.

No matches found.

c00044_gnlPro.. - Region 2 - Others_HGD_unassigned,TPP_AA_metabolism
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Download region GenBank file
Location: 101,203 - 134,421 nt. (total: 33,219 nt) Show pHMM detection rules used
Others_HGD_unassigned: (minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl, Carboxyl_trans, CoA_trans, CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans, CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III, ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C, BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C, Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))
TPP_AA_metabolism: (TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or PFOR_II))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
resistance genes
encapsulation genes
electron transport genes
other genes
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
KnownClusterBlast
Similar known gene clusters
Shows clusters from the gutSMASH KnownClusterBlast database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.

No matches found.

c00055_gnlPro.. - Region 1 - TPP_AA_metabolism
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Download region GenBank file
Location: 41,688 - 70,423 nt. (total: 28,736 nt) Show pHMM detection rules used
TPP_AA_metabolism: (TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or PFOR_II))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
resistance genes
encapsulation genes
electron transport genes
other genes
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
KnownClusterBlast
Similar known gene clusters
Shows clusters from the gutSMASH KnownClusterBlast database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.

No matches found.

c00060_gnlPro.. - Region 1 - Fumarate2succinate
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Download region GenBank file
Location: 5,653 - 24,186 nt. (total: 18,534 nt) Show pHMM detection rules used
Region on contig edge.
Fumarate2succinate: (Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or Fer4_7 or SucD_FumR))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
resistance genes
encapsulation genes
electron transport genes
other genes
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
KnownClusterBlast
Similar known gene clusters
Shows clusters from the gutSMASH KnownClusterBlast database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.

No matches found.

c00077_gnlPro.. - Region 1 - GR_AA_metabolism,Pyruvate2acetate-formate
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Download region GenBank file
Location: 84,816 - 122,583 nt. (total: 37,768 nt) Show pHMM detection rules used
GR_AA_metabolism: (minimum(1, [Gly_430_pcre, Gly_8-9_TMA, Gly_radical, Gly_radical_scatole, PFL-like, PFL_6_pcresol, PFL_9_tma, PFL_acetate1, PFL_acetate2, PFL_proline, PFL_toluene]) and not NRDD and minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or PFOR_II))
Pyruvate2acetate-formate: ((PFL_acetate1 or PFL_acetate2) and Radical_SAM)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
resistance genes
encapsulation genes
electron transport genes
other genes
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
KnownClusterBlast
Similar known gene clusters
Shows clusters from the gutSMASH KnownClusterBlast database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
c00077_gnlPro.. - Region 2 - PFOR_II_pathway
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Download region GenBank file
Location: 126,975 - 150,511 nt. (total: 23,537 nt) Show pHMM detection rules used
PFOR_II_pathway: cds(POR and POR_N and PFOR_II and EKR and Fer4_16 and TPP_enzyme_C)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
resistance genes
encapsulation genes
electron transport genes
other genes
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
KnownClusterBlast
Similar known gene clusters
Shows clusters from the gutSMASH KnownClusterBlast database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
c00088_gnlPro.. - Region 1 - GR_eut-pdu-related
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Download region GenBank file
Location: 14,421 - 50,679 nt. (total: 36,259 nt) Show pHMM detection rules used
GR_eut-pdu-related: (minimum(1, [Gly_430_pcre, Gly_radical, Gly_radical_scatole, PFL-like, PFL_6_pcresol, PFL_acetate1, PFL_acetate2, PFL_proline, PFL_toluene]) and minimum(2, [Aldedh, EutN_CcmL, EutQ, PTAC, PduV-EutP]) and not (PFL_9_tma or Gly_8-9_TMA or NRDD) and not EutB and not EutC and not (POR or POR_N or PFOR_II))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
resistance genes
encapsulation genes
electron transport genes
other genes
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
KnownClusterBlast
Similar known gene clusters
Shows clusters from the gutSMASH KnownClusterBlast database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
c00099_gnlPro.. - Region 1 - succinate2propionate
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Download region GenBank file
Location: 83,031 - 108,353 nt. (total: 25,323 nt) Show pHMM detection rules used
succinate2propionate: (minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not Cytidylate_kin)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
resistance genes
encapsulation genes
electron transport genes
other genes
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
KnownClusterBlast
Similar known gene clusters
Shows clusters from the gutSMASH KnownClusterBlast database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
c00109_gnlPro.. - Region 1 - Rnf_complex
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Download region GenBank file
Location: 1 - 25,902 nt. (total: 25,902 nt) Show pHMM detection rules used
Region on contig edge.
Rnf_complex: (Complex1_51K and minimum(5, [FMN_bind, FeS, Fer4, Fer4_9, NQR2_RnfD_RnfE, Rnf-Nqr, RnfC_N, SLBB]))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
resistance genes
encapsulation genes
electron transport genes
other genes
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
KnownClusterBlast
Similar known gene clusters
Shows clusters from the gutSMASH KnownClusterBlast database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
c00109_gnlPro.. - Region 2 - Putrescine2spermidine
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Download region GenBank file
Location: 66,602 - 89,850 nt. (total: 23,249 nt) Show pHMM detection rules used
Putrescine2spermidine: (minimum(2, [AdoMet_dc, Spermine_synt_N, Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
resistance genes
encapsulation genes
electron transport genes
other genes
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
KnownClusterBlast
Similar known gene clusters
Shows clusters from the gutSMASH KnownClusterBlast database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.