LOCUS       c00005_gnlPro..        13471 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PBIKMNCH_5.
ACCESSION   c00005_gnlPro..
VERSION     c00005_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 16:48:02
            Original ID  :: gnl|Prokka|PBIKMNCH_5
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13471
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13471
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[201:8617]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      202..8617
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..13471
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13471
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             complement(138..263)
                     /locus_tag="ctg5_1"
                     /transl_table=11
                     /translation="MPMTPNTEQDWKAWRNLMWSEILTESVKSYMDCKCLNAISI"
     CDS             complement(202..1719)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_2"
                     /sec_met_domain="Fer4_7 (E-value: 1.2e-11, bitscore: 35.0,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 1.5e-11, bitscore: 33.8,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 5.9e-06, bitscore: 16.7,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRGLYSSKTEIRHKIFTEIARMAYEGQSPEMLEELPYKIVPGEIA
                     TYRDSIFLERAVVGERLRVAMGMSLRKVTEHAPISKGVEASVIEEKYYEPPLINVIKFA
                     CNSCPEKRVMITEGCQGCLEHPCVEVCPKKAVHMEGGRSHIDEDACIKCGKCLEACPYN
                     AIIKQERPCSKACGMNAIGSDEYGRAEIDQDKCVSCGQCLVSCPFSAIVDKGQIFQTIM
                     ALKSETPVYAIVAPAIAGQFPDMENNKIRGAFQALGFTDVREVAVGADLCTVEEAKDFL
                     EEVPEKLPFMATSCCPSWSMMAKKLFPEQAKCISMALTPMVLTARLIKQKEPDCKIVFV
                     GPCAAKKLEASRKSIRSYVDFVLTFEEVAGMFDAKGVDWKDIPEGEPLFHASADGRGFA
                     VSGGVAEAVVHAVKRIDPDREVKVMNAEGLQNCKKMLQMAKIGKYNGYLLEGMACPGGC
                     VAGAGTIQTVKKAAAALEKMKKEASFTDAYDSKYRARLESLEKFDVE"
     CDS             complement(1985..2767)
                     /locus_tag="ctg5_3"
                     /transl_table=11
                     /translation="MIFTKKYRTGQIVLAACIAAVCMFSDVHGAEVAGPPAPKSKSALT
                     QKPEATPMPEATPIPASTPTPEQETETDKQNPADQGTLSKPDHPDTISADKLVFIGDSR
                     TEGLRDAVNDDSIWSCLSSMGYDWMVSTGVPQVEDQIEDNTAVIILMGVNDLYHVNDYI
                     SYINSKAAEWGNRGAQTYFVSVGPVQNDPYCSNAEIESFNAAMQASLSGVTYIDVYSHL
                     VSEGFSTVDGTHYPDSVSVDIYNYILDHLEEQMSGIWG"
     CDS             complement(2745..2873)
                     /locus_tag="ctg5_4"
                     /transl_table=11
                     /translation="MAGYAAWDVSMLLFTATHSRELRYVKSNVSITAEGNDIYEKI"
     CDS             complement(2846..3100)
                     /locus_tag="ctg5_5"
                     /transl_table=11
                     /translation="MRLEKVQEALKTKKIHYEYTEENGCGSIDFMFRGLRFHIWEYEDR
                     VWGAETNVFEAGRSQDIEGDYEEIISGEILSWPDMLPGM"
     CDS             complement(3770..5410)
                     /locus_tag="ctg5_6"
                     /transl_table=11
                     /translation="MKGLLKFITCGSVDDGKSTLIGHILYDAKLLYTDQEKALELDSKV
                     GSRGGAIDYSLLLDGLMAEREQGITIDVAYRYFTTDNRSFIVADTPGHEEYTRNMAVGA
                     SFADLAVILVDASQGVLVQTRRHARICALMGIRYFVFAVNKMDLIEYDEKRFRDIKNQI
                     AALIEELKLANVTIIPVSATEGDNVTTKSDNMPWYKGEALLSHLETVDIKEDTEKGFYM
                     PVQRVCRPNHEFRGFQGQIENGAIRAGDLVTTLPSKEEAHVKSILVGDKEVQEAVQGQP
                     VTIQLDREVDVSRGCVLTIDSGAVLTDSVEADILWMDDNALTDGKNFFVKIGTKMIPGL
                     VTKINYSVDVNTGEKKSAYTLKKNEIASCTLEFSEKIVVDEFDRHRTLGELILIDRVTN
                     MTSACGVVRKTFVSQDRSQIGKVDEQVRAGLKGQTPVVVEFPIGKEGITLDFAEQVEKG
                     LTVLGKHTYLYHPAASENYAETVRHLKAAGLIVLLVLDENTAKDETLKTLDGFYANWQI
                     DGITVKDAIDFVKKKSAFTVQSVHDGNYI"
     CDS             complement(5412..6530)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PAPS_reduct"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg5_7"
                     /sec_met_domain="PAPS_reduct (E-value: 4.2e-65, bitscore:
                     208.9, seeds: 27, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VCLKNALRKMCVTIYGRFCSDEGVVAGYDNRIRTKYTAKWGVQIA
                     GMIFQTRSSVFAQVRKDSEYKQTEEDNAMSNLSHLDALEAEAIYIMREVAAECEKPVML
                     YSIGKDSSVMLHLAMKAFYPEKPPFPFLHIDTTWKFHEMIEFRDRIAKENGIDMLVYTN
                     EEGVKAGINPFDNGSAYTDIMKTQALKQALTKYGFTAAFGGGRRDEEKSRAKERIFSFR
                     NSAQAWDPKNQRPEMWKLYNTKIQKGESMRVFPISNWTEKDIWQYIQRENIEIVPLYFA
                     KERPVIYREGNIIMVDDDRLKLRPGEKIENKKVRFRTLGCYPLTGGIESEADTLDEIID
                     ETLSAVSSERTSRVIDHEAAGSMERRKREGYF"
     CDS             complement(6561..6875)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_9"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg5_8"
                     /sec_met_domain="Fer4_9 (E-value: 1.8e-13, bitscore: 40.4,
                     seeds: 61, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 2.7e-09, bitscore: 26.9,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 2.7e-05, bitscore: 14.6,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSIRIQKSKCAGCGRCIEACPGNLIKKDKENKAFIRQVRDCWGCT
                     SCIKECRHDAIRFFLGADVGGRGASMVVSEKPDISTWTVEKPDGTKITIQVNKKDANKY
                     "
     CDS             complement(6872..8617)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 71.4; E-value:
                     2.7e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_9"
                     /sec_met_domain="FAD_binding_2 (E-value: 6e-23, bitscore:
                     71.4, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 1.3e-08,
                     bitscore: 24.8, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTERIRTDVLIIGGGTAGCFAAYVIGKKSGRKVLIAEKANIKRS
                     GCLAAGVNALNAYITEGRVPQDYVDYAKKDAHGIVREDLLLTMSERLNHVTKVMEDLGL
                     VILKDENGKYVARGNRNIKINGENMKPILAKAAAEQENVTVLNHVNITDYKTENKKVTG
                     AVGFSVNEDIFYDIDAKAVLCATGGAAGLYRPNNPGFSRHKMWYPPFNTGAGYAMGLLS
                     GAEMTTFEMRFIALRCKDTIAPTGTIAQGVGARQVNAHGDIYETKYGLTTSQRVYGTVM
                     ENREGNGPCYLRTEGISKEQEQDLYKAYLNMAPSQTLKWMEAGKGPSEENVEIEGTEPY
                     IVGGHTASGYWVDNNRATTIEGLYAAGDVAGGCPQKYVTGALAEGEIAAEAILEYLNGK
                     DDDRIAAENKEEALERGGEQELSQTAIVKKAEYESHLNASRSLMNAEQLEEAMQKIMDQ
                     YAGGIGTDYRYSGMSLAKADEKIAALLPVVDTLAATDTYELMQIYELRERLIVCQAVIA
                     HLAARKETRWHSFGENTDYPQQSEEWMKYVNSRMENGEIKILYRDLITKENTGLNTAEK
                     GAGER"
     CDS             complement(8729..9787)
                     /locus_tag="ctg5_10"
                     /transl_table=11
                     /translation="MYVELKNINKTYGSYQASRNVNFGIEKGKLIGLLGPSGSGKTTIL
                     RMIAGLETPDSGEVIIDGKVVNDVPSSQRGIGFVFQNYALFRYMTVYDNVAFGLKVQKA
                     DKKKIDARVRELIKLVGLEGLEKRYPSQLSGGQRQRVAFARALAPNPQVLLLDEPFAAI
                     DAKIRQELRSWLKEMIGKLGITSIFVTHDQDEAIEVADEIIITNAGRIEQKGTPIGVYR
                     NPETAFTASFFGQPSVLKNADDFHTFAQAEGADKIIVRPEFVKISKLDEVEKFKTSVSR
                     GVVERVSFRGDNLELQVRVNNSVVTARRSLEKADIREGENVNVFLYRIFALRGDSVQLI
                     ENEAVRDDFVII"
     CDS             complement(9789..10613)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 60; E-value: 8.2e-19)"
                     /gene_kind="transport"
                     /locus_tag="ctg5_11"
                     /sec_met_domain="BPD_transp_1 (E-value: 1.8e-19, bitscore:
                     60.0, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDNNEKTSEKITKWLLVVISVLFLAVMLLLPLITVITEALRSGWK
                     VYAAAVTDEYTIKALLLTVKATLFAVVFNTVFGVFAAWALTKFQFRGKKLLTTLIDLPV
                     TISPVIAGLIFLLIFGRQSPVYFFLMKLGIKVVFSVPGIIIATVFVTFPFISRELIPVL
                     EAEGSDEEEAAALMGAGGWTIFWKITFPHIKWALLYGVVLCTARAMGEFGAVSVLSGHL
                     RGKTNTLPLHVEILFNEFQYVPAFAVSSLLVIMAVIILVVRSLIEYKGKKEA"
     CDS             complement(10613..11449)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 83.7; E-value: 4.4e-26)"
                     /gene_kind="transport"
                     /locus_tag="ctg5_12"
                     /sec_met_domain="BPD_transp_1 (E-value: 9.8e-27, bitscore:
                     83.7, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKRNKPVIPGFGLSMGITISILSLVVLIPLASLVVYTAKLSFKD
                     FIETITRARVLASFYTSFVCAFAAAVINGIMGTILAWVIVKYDFPGKRLMDGVIELPFA
                     LPTAVAGIALTSLTSDSGIVGSFFAGFGIKIAYTRIGITVAMIFVGIPFVVRSVQPVLE
                     KMDNSYSEAAGVLGAKKTTIFWKVIFPELKPAIFAGTGLAFGRCLGEYGSVVFIAGNKP
                     YYTEITPLVIMSELQEFDYSSATAIALVMLAVSFFILFLNSMIQQRNARILRGGNA"
     CDS             complement(11520..12518)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SBP_bac_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1044:Bacterial extracellular solute-binding protein
                     (Score: 57.1; E-value: 9.5e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg5_13"
                     /sec_met_domain="SBP_bac_1 (E-value: 2.1e-18, bitscore:
                     57.1, seeds: 129, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRKLFAFGLAVVLALMPVQAFGKTVSITNVSYDPTREMFEQYNK
                     IFEDHWKEKTGDDVEVIQSHGGSGKQALEVANGLDADVVTLALEYDIESIENAGLIKAG
                     WKDKFDNDSSPYTSTIVFLVKKGNPRDIKDWDDLTKKGVGVVTPNPKTSGGARWNYMAA
                     WAYADKKYGGDEAQMKEFIKKLYRNVVVLDSGARGATTSFVENGQGDVLVAWENEAYLS
                     MRDYPDEYEIVTPSVSILAQPSVAVVDEVVDYRDTRDVATEYLNYLYSDEAQEIAAENY
                     FRPTNEKILKKHSDTFDLNINLANISDYGGWDKVQEKHFTDGGIFDQIYER"
     CDS             complement(12720..13208)
                     /locus_tag="ctg5_14"
                     /transl_table=11
                     /translation="MPKNKFQEVIFTIIMVFVMVYAMICYNIVLNTGTMTNETFLLAFH
                     ELTFMGPIAFILDFFIIGGLAKKIAFGVVDMRRDNPFHLVLAISAVSVAFMCPCMSFAA
                     TVLIKHAPASQIIPTWLQTTAMNFPMAFFWQIFYAGPFVRFIFGKLFPEKEKAAASAE"
ORIGIN
        1 acaccggaaa taataaaagt agctgtataa ctctaaagag caaacagtag tggtgtcatg
       61 gatgcaccct gaaaaaaggc ggtatcccgc cttaattcag atgctctggt aactcagttg
      121 ccgagtaatt cactctgcta tatactgatt gcattcaaac acttgcaatc catataggat
      181 ttcactgatt cagtcagaat ctcactccac atcaaatttc tccaggcttt ccagtcttgc
      241 tctgtatttg gagtcatagg catctgtaaa cgaagcctct ttcttcattt tttcgagagc
      301 tgctgctgct tttttaactg tctggatagt accggcacct gctacacagc cgcccggaca
      361 tgccattcct tccaaaagat atccattata tttaccaatc ttggccatct ggagcatctt
      421 cttacagttc tgcagacctt ctgcattcat tacctttact tcccgatcag gatcaatacg
      481 cttcaccgca tggacaaccg cttctgccac accaccgctg actgcgaaac ctcttccgtc
      541 agcactggca tgaaacagtg gttctccttc cggaatatct ttccagtcca cgcctttggc
      601 atcaaacatt cctgctactt cctcgaaggt cagcacaaaa tccacatagc tgcggatact
      661 cttacggctg gcttccagct tcttggctgc acagggacct acgaaaacga tcttacaatc
      721 tggttccttc tgcttgatca gccttgcagt gagaaccata ggtgtcagtg ccatagagat
      781 acatttcgcc tgttccggga ataatttctt agccatcata gaccaggacg gacaacagga
      841 tgtagccatg aaaggaagtt tctcaggaac ttcttccaaa aagtcctttg cctcctccac
      901 tgtgcacaga tctgcaccga cggcaacctc tcttacatct gtaaagccaa gtgcctgaaa
      961 tgctccccgt atcttattat tctccatatc cggaaactgg cctgcaatgg caggcgccac
     1021 gattgcatac accggtgttt cactttttaa tgccataata gtctggaaaa tctgtccttt
     1081 gtctacaata gcactgaacg gacaacttac cagacattgt ccgcaggata cacatttatc
     1141 ctgatcaatc tctgctcttc catattcatc agagccaata gcattcatac cgcatgcctt
     1201 tgaacatgga cgttcctgtt tgatgattgc attatacgga caggcttcca gacactttcc
     1261 gcatttgata caggcatctt catcaatatg ggatctgccg ccttccatat gcactgcttt
     1321 ctttggacag acttccacac agggatgctc caggcacccc tgacagccct ctgtgatcat
     1381 tacccttttt tcagggcagg aattacaggc aaacttgatc acattgataa gcggcggttc
     1441 ataatacttt tcctcaataa cgctggcctc cacacctttg gaaattggcg catgctctgt
     1501 aacctttctc agtgacatcc ccattgcaac gcgaagtctc tcaccaacta ccgctctttc
     1561 cagaaaaata ctgtcacgat aagtcgcaat ttcaccgggt acgatcttgt agggaagctc
     1621 ttccagcatc tccggagact ggccttcata tgccatcctc gcaatttctg taaaaatttt
     1681 gtgtctgatt tctgttttgg atgaatacag tcctctcatt ttttcctcct gattttcgat
     1741 tcggataact gtacggcaat ccaatgcagg gacaccgaac aatttccatt tataatttca
     1801 tcactgctgc aatcagcaca ctcatttttc ctcctgctga actttcagcc acttcacaga
     1861 gaaacgaaat tccgctcatt tccgtttcct tatctgcata tcatatcacc aaatgcttcc
     1921 aggctcaaca caacatcaga attttcgctg aattgtcgcc cccgaagttg ctgttcatat
     1981 gttgttatcc ccagattcca ctcatctgtt cctccagatg gtccaagata taattataaa
     2041 tatctacgga cacactgtcc ggatagtggg ttccgtctac ggtggaaaat ccctcagata
     2101 ccagatggga atatacgtct atgtaggtaa ctccactcag gcttgcctgc attgccgcgt
     2161 taaaactttc aatctccgca ttactgcaat agggatcatt ctgcaccgga cctacagaca
     2221 cgaaataagt ctgcgctcct ctgttccccc attcagcagc tttggaatta atataactga
     2281 tgtagtcatt gacatgataa agatcattaa cacccatcag gataataacc gctgtattgt
     2341 cctcaatctg atcttctacc tgcggcactc ctgtagatac catccagtca tatcccatag
     2401 aagaaagaca ggaccaaatg ctgtcatcgt ttaccgcatc cctcaatccc tctgttctgg
     2461 aatctccgat aaataccagt ttatctgcgg agatagtgtc cggatggtct ggcttgctta
     2521 aagttccctg gtctgccgga ttctgtttat ctgtctcagt ttcctgctcc ggtgttggag
     2581 tagatgcagg tattggtgtt gcttcaggca ttggtgttgc ttcaggtttt tgtgtcagtg
     2641 ccgatttgga tttcggtgcc ggcggacctg ccacttctgc cccatggaca tctgaaaaca
     2701 tacagacagc tgcaatacat gcggctaata cgatttgtcc ggttctatat tttttcgtaa
     2761 atatcattcc cttctgcagt aatacttacg ttacttttca catatctcaa ctccctggag
     2821 tgtgttgctg tgaacagtaa catacttaca tcccaggcag catatccggc catgagagga
     2881 tttctccgga aataatttcc tcgtaatctc cttcaatatc ctggcttctg cctgcttcga
     2941 acacgtttgt ctccgctccc cagacacgat cttcatattc ccatatatgg aatctcagac
     3001 cgcgaaacat aaagtcgatg cttccgcatc cattttcctc tgtatattca taatgaattt
     3061 tctttgtttt taacgcttcc tgtacttttt ccaaacgcat aaaatacctc ctgattatct
     3121 gtacagtacc ttctgtaata taatacagat aactttcact gtaaaaaaat gttctcgtgt
     3181 acacccatca aaagtcaaac agatattcgc aatccgcttc gctacacagc tctacatatt
     3241 ctcttaatcc taacgccatt atacaaaacg aattatatca tactctgctg cataatatgt
     3301 aatctgaatg ccacttcaca attgccgtta ctgttcactc cgttcacagt aacttagcca
     3361 aaattcattt cagattgcct gtggcaatgg aattttggct tgtatgtctc gggattttgg
     3421 catattcatg ccaaaacacc tcgcgggata atggtgtgtg aacagtaacc aattgcccat
     3481 tctacattct gatcgatatt cactcatctt tatttctgtc ttttcttcgt tggtatcgcc
     3541 aggatgatga tcgtagcaat tacaaacaaa gttccaagca tcatctcttt ttttggtttt
     3601 gtttactttc attgttcgtt tgcatatttc tgttatcttt cctgtctgta ttattatgga
     3661 ttctgaatat ttgaaaataa gtataatccg ctgtaacgac acttgtcaag aaaacaaaat
     3721 accgcagaga ctttctttgt ctctgcggcg atttatagcc ctgttataat cagatataat
     3781 ttccatcatg tacactctgc actgtaaatg cagatttctt tttcacgaaa tcaatcgcat
     3841 ctttcacagt gattccgtca atctgccagt tcgcatagaa accatccaga gtctttaatg
     3901 tctcgtcttt tgctgtattt tcatcaagaa caagaagtac gatcagacct gctgccttaa
     3961 gatggcggac agtttctgca tagttttcac tcgctgccgg atgatacaga taggtatgtt
     4021 ttccaagtac agtcagtccc ttttctacct gctctgcaaa atcaagagtg attccttctt
     4081 taccgatcgg gaattccact actaccggtg tctgaccttt cagtcctgca cgaacctgct
     4141 cgtccacttt tccgatctga gatctatcct gagaaacaaa ggtttttctc acaacaccgc
     4201 aggcagaagt catatttgtg acacgatcta tcaggatcag ctcacccagt gttctgtgcc
     4261 tgtcaaattc gtccacaacg attttctctg agaattccag agtacaggaa gcaatctcat
     4321 ttttctttaa ggtatatgcg cttttctttt cacctgtatt aacatccaca gaataattga
     4381 tctttgtaac caggccgggg atcatctttg taccgatttt tacaaagaag ttcttgccat
     4441 ccgtaagagc attgtcatcc atccagagga tatctgcttc cacagaatct gtaagaactg
     4501 cgccggaatc aatggtaagt acacatccgc gggaaacatc tacttctctg tcaagctgga
     4561 tggtaacagg ctgtccctgt acagcttcct gaacttcttt atcgccaaca agaatactct
     4621 ttacatgagc ttcttcttta ctgggaagag tagtcacaag gtcgcctgcc ctgatggcac
     4681 cattttcaat ctgtccctgg aatccgcgaa actcatggtt tggtctgcag actctctgta
     4741 caggcatata gaagcccttc tctgtatctt ccttaatgtc tacggtttcc agatgggaaa
     4801 gaagcgcctc acctttatac catggcatgt tgtcagattt ggttgtaacg ttgtcacctt
     4861 ctgtggcaga taccggaata atagttacat tggcaagttt cagttcttct atcagtgctg
     4921 cgatctgatt cttaatgtcg cggaaacgtt tttcatcata ttcaataaga tccattttgt
     4981 ttactgcaaa tacaaagtaa cggattccca tcaatgcgca gattcttgca tgacgtcttg
     5041 tctgtaccag tactccctgt gaagcatcca ccaggataac tgccagatct gcaaaggacg
     5101 cacccactgc catgtttctt gtatattctt catgtccggg tgtatctgca acaatgaagc
     5161 ttctgttatc tgttgtaaaa taacggtatg caacatcaat ggtgattccc tgttcacgct
     5221 ctgccatcag accgtccaga agaagagaat aatcaatggc accgcctctg cttcctactt
     5281 tggaatccag ctccagagct ttctcctgat ctgtatagag aagctttgca tcataaagaa
     5341 tatgtccgat cagagtggat tttccatcat ccacacttcc gcatgtaata aatttcaata
     5401 atcctttcat tctagaaata cccctctctc tttcttctct ccatgctgcc tgctgcctcg
     5461 tggtcgatca ccctgctggt acgttcagaa gaaacagcac ttaacgtctc atcaataatc
     5521 tcatccagag tatctgcttc agattcaata cctccagtaa gcggatagca tccaagagta
     5581 cggaatctga cttttttgtt ttcaatcttt tcacccggac ggagttttaa tctgtcatca
     5641 tccaccataa tgatatttcc ttctctgtag atgaccggtc tttctttcgc aaaatataac
     5701 ggtacaattt cgatattttc acgctgaatg tactgccaga tatccttttc tgtccagttg
     5761 gaaattggga atactcgcat actctctccc ttctggatct tagtgttata aagcttccac
     5821 atctccggtc tctggttttt cggatcccat gcctgagctg aattacggaa agaaaagatt
     5881 ctctcttttg ctctggattt ctcctcgtca cggcggccgc ctccaaatgc cgctgtaaat
     5941 ccatatttgg tcagagcctg ttttaacgcc tgtgttttca tgatatctgt atatgcagaa
     6001 ccattgtcaa atggattgat tcctgccttt acaccctctt cattggtgta aaccagcata
     6061 tcaattccgt tttcctttgc gattctgtcg cggaattcaa tcatctcatg gaatttccat
     6121 gtagtatcaa tgtgaaggaa cgggaatggc ggtttctccg ggtaaaatgc cttcatcgcc
     6181 agatggagca taacggagct gtcctttcct atagaataga gcataaccgg cttttcacac
     6241 tcggctgcta cttctcgcat aatataaatc gcctctgcct caagcgcatc aagatgagat
     6301 aagttactca ttgcattatc ctcctctgtt tgtttatact cggaatcttt tcgtacttga
     6361 gcaaatacac tagagcgtgt ctgaaaaatc attcccgcaa tctgcacgcc ccactttgcg
     6421 gtatattttg tccgaattcg gttgtcgtag cccgctacga cgccctcatc cgaacaaaat
     6481 ctcccataaa ttgtgacgca catcttgcgt aaagcatttt tcaaacacac tctaaagact
     6541 ctgagagtac atacttatgt ttaatattta ttagcgtctt tcttattaac ctgaatagtg
     6601 attttagtgc catccggctt ctccactgtc catgtggaaa tatccggttt ctctgataca
     6661 accatacttg cacctctgcc tcccacatca gctccaagga agaagcggat ggcatcatgc
     6721 ctgcattcct taatacagga agtacatccc cagcagtctc ttacctgacg gataaaggct
     6781 ttgttctctt tatccttttt gatcagattt ccgggacagg cttcgataca tctgccgcat
     6841 cctgcacatt tacttttctg aatccgaatg ctcatctctc acctgctcct ttctctgctg
     6901 tattcaaacc tgtattttcc tttgtgatca ggtcacgata taagatctta atctcgccgt
     6961 tttccatacg ggagtttaca tatttcatcc actcttcgct ctgctgcggg tagtctgtat
     7021 tctctccgaa actatgccat ctggtttcct ttctggctgc cagatgtgcg atcactgcct
     7081 ggcacacgat cagtcgttcg cgaagttcat aaatctgcat cagttcataa gtatctgttg
     7141 ctgccagagt gtcaactact ggcaacaatg ctgcaatctt ttcatctgcc tttgcaagac
     7201 tcatcccgct gtatctgtag tctgtaccga ttcctcctgc gtactgatcc atgatcttct
     7261 gcatggcttc ctcaagctgc tctgcattca tcaaagaacg ggaagcattc aaatgtgatt
     7321 cgtattctgc cttcttaact attgcagttt gagacagctc ctgttctccg ccacgctcta
     7381 aagcctcttc cttattttcc gctgcgatcc ggtcatcatc tttgccattc agatattcca
     7441 aaatcgcctc tgctgcaatc tcaccttctg ccagtgcgcc ggttacatat ttctgcggac
     7501 atcctcctgc tacatctccg gctgcatata aaccttcaat agttgtagct ctgttattat
     7561 ctacccagta accgctggct gtatgtccgc ctacaatata tggctctgtg ccctcaatct
     7621 ctacattctc ttcggatggt ccttttccgg cttccatcca tttcagagtc tgggacggtg
     7681 ccatattcag gtaagctttg taaaggtcct gctcctgttc tttggaaata ccttctgttc
     7741 tgagataaca tggaccgttt ccttctctgt tctccatgac tgtaccgtaa actcgctggg
     7801 aagttgtcag accatatttt gtttcataaa tatcaccatg tgcattgacc tgtctggccc
     7861 caacaccctg agcaatagtt cctgtaggag caatcgtgtc cttacatctc aatgcaatga
     7921 aacgcatctc aaaggttgtc atctccgcac cggaaagaag tcccattgca tatcctgcac
     7981 ctgtgttaaa cggaggatac cacatcttat gtctggaaaa tcccggatta ttcggtctgt
     8041 aaagtcccgc tgcaccacct gtggcacaaa gaactgcttt cgcatcaatg tcatagaaaa
     8101 tatcctcatt aacgctaaat ccaactgcgc ctgtgacttt tttgttttct gttttataat
     8161 ctgtaatatt tacatgattg agaactgtaa cattctcctg ttcagctgcc gcctttgcaa
     8221 ggattggctt catattttcg ccattgatct tgatgtttcg gtttcctctg gcaacatatt
     8281 ttccgttttc gtccttcagg atgaccagcc ccagatcttc catcaccttt gtcacatgat
     8341 tcagtctctc tgacatggta agaagaaggt cttctcttac gattccatgg gcatcctttt
     8401 tggcataatc cacataatcc tgtggcactc tgccttctgt aatatatgcg ttcaatgcat
     8461 tcacgcccgc cgccagacat ccgcttcgct taatattcgc tttctctgcg atcagaactt
     8521 ttctgccgct ttttttgccg atcacatagg ctgcaaagca tcctgccgta ccgccgccga
     8581 tgatcagcac atctgtcctg attctctctg ttctcattct ctcttaccct ttcctccata
     8641 ccagtgtgcc aacaagttga tttcccgatc agtcttgcgt ctgaatttct tatttcttca
     8701 ttgtcgtcag tcgccgcagc caccgctgtc agataattac aaagtcatcc cttacagcct
     8761 cattttcgat cagctgtaca ctgtcacctc tcagtgcaaa aatcctgtaa aggaatacat
     8821 tcacattctc accttcccgg atatctgctt tctccaggct tcttctggca gttactacgg
     8881 aattgttgac tctcacctga agttccagat tatctcccct gaaagaaacc cgttcaacca
     8941 ctccccggga tacggaagtt ttgaacttct ccacctcatc cagtttggag atttttacaa
     9001 attccgggcg gacaataatc ttgtctgctc cttctgcctg agcaaaggta tggaaatcat
     9061 ccgcattttt caacacagat ggctgtccga agaaggacgc tgtaaaagct gtctcaggat
     9121 ttctgtaaac ccctatggga gttcctttct gttcgatccg tcctgcatta gtgataataa
     9181 tctcatctgc tacttcaatg gcctcatcct gatcatgagt aacgaaaata ctggtaattc
     9241 ccagctttcc gatcatctct tttaaccagc ttcgcagttc ctgacggatt tttgcatcaa
     9301 tggctgcaaa gggctcatcc agaagcagca cctggggatt tggagcaagg gctctggcaa
     9361 atgccaccct ttgcctctgg ccgccagata actggcttgg atatcttttt tccagtcctt
     9421 ccagccccac cagtttgatc agctctctga ctctggcatc aattttcttc ttatcagcct
     9481 tctgaacctt caaaccaaat gcaacgttgt cataaactgt catatagcga aacaacgcat
     9541 aattctgaaa tacaaatcca atcccacgct gactggacgg aacatcattt accacttttc
     9601 catcaataat gacctctccg ctgtccgggg tttccaggcc tgcgatcatt cgaagaatag
     9661 ttgtttttcc gcttccgctt ggtcccagca gaccaatcag tttacctttc tcaattccga
     9721 aattcacatt ccttgatgcc tggtaagaac catatgtctt attgatattt tttaactcta
     9781 catacatatc aggcttcctt ctttccttta tattcaatca ggcttctgac taccagaatg
     9841 ataactgcca tgatcacaag cagcgaagat acggcaaacg ccggaacata ctgaaactca
     9901 ttaaacaaaa tctctacatg aagaggaagt gtattggtct ttcctcttaa atgtccggaa
     9961 agtacagata ccgctccaaa ctctcccatt gctcttgccg tacagagcac aactccatac
    10021 agtaatgccc atttgatatg agggaatgtg atcttccaga aaatggtcca tccacctgct
    10081 cccatcaggg ctgccgcttc ctcctcatcg cttccttctg cttccagaac cggaatcagt
    10141 tctctggaaa taaaaggaaa ggttacaaat acagttgcaa taatgattcc cggtacagag
    10201 aatacaactt taatccctaa cttcatgaga aaaaagtaaa caggactctg ccgtccgaaa
    10261 atcagaagaa agatcaaacc tgcaataaca ggggaaatag taaccggaag atcgatcagg
    10321 gtagtgagaa gctttttacc cctgaactga aacttcgtca gtgcccaggc tgcaaaaaca
    10381 ccaaaaacag tgttaaaaac aactgcaaag agtgttgcct tcactgtaag aagaagtgct
    10441 ttgatggtgt actcatctgt cactgcagct gcatagacct tccatccgct ccgcaatgct
    10501 tctgtgatca cagtgatcag aggaagaagg agcatgactg ccagaaacag aacactgatc
    10561 acgacaagca accattttgt aattttctcc gaagtctttt cattgttgtc catcaggcat
    10621 ttcctcctct taaaattctt gcatttctct gctgtatcat actgttaagg aacagaataa
    10681 aaaatgaaac tgccaacatc acaagtgcga ttgccgttgc acttgaataa tcaaattcct
    10741 gaagctctga cataataacc agcggtgtga tttctgtata atagggttta tttcctgcga
    10801 taaatacaac acttccatat tcacccagac atcttccgaa cgcaagtccg gtccctgcaa
    10861 agatcgcggg cttcagttcc ggaaaaatga ccttccagaa gatagttgtt ttctttgctc
    10921 ccagcactcc tgctgcctcg ctgtaagaat tatccatctt ttccagaacc ggctgtacac
    10981 ttcgcacaac gaacggtatt cctacaaata tcatagccac tgtaatacct attcttgtgt
    11041 atgcgatctt gataccgaat cctgcaaaaa agctgccgac aattcccgaa tctgaggtca
    11101 gggatgtcag tgcaatacct gctaccgctg tgggaagagc aaagggaagt tcgatcaccc
    11161 catccataag tctcttgccc ggaaaatcat atttcacaat cacccacgca agaatagttc
    11221 ccataattcc atttattact gctgctgcaa aagcacatac aaaactggta taaaaggatg
    11281 ccagcactct ggcccttgtg atggtttcga taaaatcttt aaaactcagc ttcgctgtgt
    11341 agaccaccaa gcttgccagg gggatcagaa ctaccagact caatatggaa atggtaattc
    11401 ccatggagag cccaaaccct ggaatcaccg gtttatttct ttttttcata atcaattacc
    11461 acctctcctg tctcatatat tctgtctgtg cttatgctct tgcttcatct tgtcttcctt
    11521 tatctctcat aaatctgatc gaaaattccg ccatctgtga aatgtttctc ctgcacttta
    11581 tcccatccgc cataatcact gatatttgcc agatttatat tcagatcaaa cgtatcactg
    11641 tgcttcttca ggattttctc attagtgggg cggaaataat tctctgctgc gatctcctgt
    11701 gcttcgtcgg aatacagata attcaaatac tctgttgcca catctcttgt atctctgtaa
    11761 tccaccactt catctaccac cgccacagaa ggctgtgcca gaatacttac gcttggagta
    11821 acaatctcat actcatccgg ataatcccgc atggatagat aagcttcatt ttcccacgca
    11881 accagcacat ctccttgtcc gttctccacg aaagaggtcg ttgcacctct tgcgcctgag
    11941 tcaagaacca ccacattccg gtaaagtttc ttaataaatt ccttcatctg cgcttcatcg
    12001 ccaccatact ttttatctgc gtaagcccac gctgccatgt agttccatct ggcaccgccg
    12061 gaggttttcg gatttggtgt tactactccc actccttttt tcgtcagatc gtcccagtct
    12121 ttgatatccc tgggatttcc tttcttcacc agaaatacga tagtggatgt ataaggagaa
    12181 ctgtcattgt caaatttatc tttccatcct gccttgatca gccctgcatt ttcaatagac
    12241 tctatatcat attccagtgc cagggttacc acatctgcat ccagaccatt ggctacctca
    12301 agtgcctgtt tccctgaacc accatgggac tgtatcactt ccacatcatc cccggtcttc
    12361 tccttccagt ggtcttcaaa tattttatta tactgttcaa acatctctct ggtaggatca
    12421 taggaaacat tagtgataga caccgttttt ccaaaagcct gtaccggcat cagtgccagt
    12481 acaactgcaa gaccaaaggc aaataatttt ctgatcatgt ttcatctcct ttaaggtacc
    12541 agtagttttt tgcattctct acttttcata gttattcgat atgttttata tgatattaca
    12601 agaaatgaca gaatttgtca atagtgtatt aaaataagta caatttatgt tgtgtagata
    12661 agaacacaaa aaagcagcat cctgaaatac agaatgctgc agtcaaaatt acatattttt
    12721 tattcggcag aagctgctgc cttttctttc tccggaaaaa gctttccgaa aataaatctt
    12781 acgaatggtc cggcataaaa aatctgccag aagaatgcca tcggaaagtt cattgctgtt
    12841 gtctggagcc atgtgggaat gatctgactt gccggtgcat gtttgatcag cacagttgcc
    12901 gcaaagctca tacatggaca cataaatgca acggatactg ctgagattgc aagtacaagg
    12961 tggaacggat tatctcttct catatccaca acaccaaatg caatcttctt tgcaagacca
    13021 ccgatgataa agaaatcaag aataaatgca atcggtccca tgaatgttaa ttcatgaaaa
    13081 gctaacagaa atgtctcatt tgtcattgtc cctgtgttca gtacaatgtt gtagcagatc
    13141 atggcataaa ccattacaaa caccatgata atcgtaaaaa taacttcctg aaacttgttt
    13201 ttaggcataa aaaatcctcc ttagatagta tgaataacat caattagaga tttgtgttgt
    13261 tcataaccat ccaggaggat gtaccgtttc caataatacc aaatatctgt ttcacaaatt
    13321 taccgttgat tattatacgg actgttataa aaaaagtcaa ggattttttc agtacctgca
    13381 gtgtgaatca gggaacgtta ctgttcactc cgttcacagt aacgtagcca aaattcattc
    13441 cagattgcct gcggcaatgg aattttggct t
//
