LOCUS       c00258_gnlPro..        16940 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GPOBHNGP_258.
ACCESSION   c00258_gnlPro..
VERSION     c00258_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2025-04-30 18:02:48
            Original ID  :: gnl|Prokka|GPOBHNGP_258
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 2723
            Orig. end    :: 19663
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16940
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[12723:15974]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13251
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..16940
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16940
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="1"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             1245..1940
                     /locus_tag="ctg258_6"
                     /transl_table=11
                     /translation="MPQKIFIVEDDDVIAKTIGNYLNRWAFTVELVQKFDQVDAEIRAA
                     APDLVIMDISLPYFNGFHWLSELRKHSKVPVIFLTSSGDDMNLVMAMNLGADDFLAKPI
                     ELPVLLAKIQGMLRRTYQYQQTDTNLNHGEFTLVPTDNQLRSPTQVIDLTPTETKLLSL
                     LFGADGEVVTREAMIEKLWEGDEFIDRNALAVNMNRLRKKVAPVGLNQLIETVKGKGYR
                     LANKEGGHD"
     CDS             1933..2892
                     /locus_tag="ctg258_7"
                     /transl_table=11
                     /translation="MIKAFLRARWMVWLSLLVLLVASLLANWLINASLEVALNSWFFAL
                     IPLLVIGGCDFWRFRREWSQLQGDVTLLAADQISNPLGQVYFQKIQMLQQTLRQNHDTY
                     RDQEQETVDTLQLWTHQIKTPLTALDLLLQVEPVNASDARLEVGKINRYLTVMLNYLKL
                     TTLNTDLVLTELPLKPLVNETVRDLAKLFIAKDLTVTVETLPTVVSDSQWLRFIFEQLL
                     TNAIKYTPHGSIRIYAKGDAVLVADTGIGILPEDLPRIFEQGYSGYNGRANQKASGLGL
                     FLSRQIAQKLGLHLTVTSKVGVGSTFAIHFPQTRWLAE"
     CDS             2986..3756
                     /locus_tag="ctg258_8"
                     /transl_table=11
                     /translation="MSTLLKLKNVEKTYTSRGAQPVQALVNISFSVESGEFVAIMGESG
                     SGKSTLLNLIATLDDPTGGEISLNGQDLRKVKEGARAKFRREHLGFIFQDFDLLDTFNV
                     QDNIFLPLVLAKKPLEIMKNRLTQLAPRLGITDLLKKYPYELSGGQQQRVAAARAMITE
                     PEILLADEPTGALDSRTSSELLDLLTDVNADSKQTILMVTHSAVAASHSQRVLFIRDGQ
                     IFHQLYRGELQQPEFLTRISETMTAMLTKEGEAQ"
     CDS             3753..5738
                     /locus_tag="ctg258_9"
                     /transl_table=11
                     /translation="MKFYFKLAATNLKADRRLFVPFVITTSFLMAINLIMLNAYTSSDV
                     LFRQFGQAAGKSLFSFGSMTTAIISVILIIYANNFLRKQRIRQLGLYNIIGFGKRELSK
                     MMATEKLLLLLTTLLCGGILGTVLSRLSYLTLAKMLHVNHNLDFGLSQTAFSIAGLITI
                     GLFIVLILVDEFWLLRKHPIELVREQNAGEREPKTKWLTLIVSIASLAAGYTIAVTVKN
                     PLQAMSLFFFAVVLVIVGTYGLFTSGSVFVLKWLRHRKNYYYKPKHFINVSNLLYRMQQ
                     NGAGLASIAILVTMTLITLATTATLFFGIHEIVNSQTPVDLAYSINPKRPDAANQLQTL
                     AKTYHVKIHSMRTFTGPSSTLALLEKNKLDSQANFNGPFSFNNARSVQLMTVENYNRYT
                     GKHVALNHDEILIYASNHYQPATLRIGKQTYHVAKQVTSFPNAPKTFIPNLFVALPSDA
                     QLLTALHALYPKRSMALLKADVTTNQDVTLSGSHANQVKLYHAVVKSGIALPESVQSRA
                     ANYDDTASMMSSFLFLGVVFGVTFILATLLILYYKQLAEGYADARRYTILQRVGLSLRE
                     VRATINSQLLTLFYLPLIVAAIHVGFALPFVQRIMMLFGLPDWQFFLTVSLITLAIFAV
                     IYVLMYRLTGNVYYRIVSRRQPSSRG"
     CDS             complement(5936..7048)
                     /locus_tag="ctg258_10"
                     /transl_table=11
                     /translation="LSTQNYPKLIQAMLPSLPDYIQDYYHSQKAIPIADSTLYQYLHFY
                     QEFLHWLISSRVTDAVSPQNVPLETLERLSLRDAQAFMAYLLERPSKTHPNKRMTRRSV
                     ALRLVGIKALYRFLTEESEPNANGEPYFYRNVWNKVKLKTHAETTTYRNHKLQEMLFVD
                     GEDARFLQWLDQQYAQQLPSKPRAYFEATKERNLAIIALLFGSGVRVSELVNMNLEDLN
                     MDRHTVQVVRKGNFQDRVNFADWIDPYLTAYLKSRTAMIGHQKPTSPLFVTQIGQTVNR
                     IRQNTIEAFFKRYTTAYGRPSTPHKARHTLGTNIYTVTKDVQQVADQLGQTTTSATDLY
                     INLSDKSGKAALREVSETAAKALDQHPQQP"
     CDS             complement(7949..8881)
                     /locus_tag="ctg258_11"
                     /transl_table=11
                     /translation="MTTLIFGHQNPDTDAITSAMSWAEFQKQAGNTDVEAVALGEPNDE
                     TKFVLDHFKVAAPRVIKTAANETGHVMLVDHNEFQQSVADIEDVQIDSVVDHHRIANFH
                     TASPLYYRAEPVGSTNTVIFELFQEHGYEISPTLAGLMASGLISDTLLLKSPTATDKDK
                     KILPEMAKIAGIDLQSYGLAMLKAGTNLAAKSDMDIIEGDAKSFTMGGKSIRIGQVNTV
                     DLDDIYARQDELVAAMTKEAQAKGYDDFLLIATDILNSNSTGFAVGADRDKVAAAFNEK
                     FDANDRLALPGVVSRKKQVVPPMQGAFEG"
     CDS             complement(8911..9879)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     55.5; E-value: 1.4e-17)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg258_12"
                     /sec_met_domain="LysR_substrate (E-value: 4e-27, bitscore:
                     85.0, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 3.5e-18, bitscore: 55.5,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTKQERIFSSKTLTYFLQLAETMNYTQSAQLLGITQPALTQQIK
                     KLERTVGAPLFYSVGKKLHLSDAGRTMLKATHEIYEILNQTTDEIQQSTSATVGKINIG
                     LLSSIEDSAFNTFIAHYYDLNPEVEITLRMMTRHEIWEALENNQIDLAIMNLPDETIKN
                     WKPYASKKILDEQLLFLHHDNSLANRKRLHFKDTLAEPWVTYPDDYFLGQLLHEAYKNQ
                     MVDFPHVVAHFTTPYQLTQFVNHTGVNTALPTSFVAAHADQIKAHAVAFEPAIRFETSF
                     VYRKEKADIPRIANFFKTFDAHLSEKDYLSRVSENSGKIER"
     CDS             complement(10001..10852)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 65.9;
                     E-value: 1.5e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg258_13"
                     /sec_met_domain="Radical_SAM (E-value: 2.6e-26, bitscore:
                     83.1, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLIDQSQSPLNILEQVGQDHEGPIKGYVHSVESFGSVDGPGIRF
                     VVFMQGCRMRCQYCHNPDTWNIGVGEEMTADQILADAQRYKAFWGEQGGITCSGGESLV
                     QIDFILELFTKAKELGISTCLDTSGGPFTRDQPWFGQFEKLMAVTDISLVDIKHIDSVE
                     HKKLTGFPNENILDMVQYMSDHGDDMWIRHVLVPERTDFDPYLKRLGDYIATLDKRVVQ
                     KVEILPYHTLGVKKYHELGITYPLEGIEPPSADRVKNAENLLHVEDYTGWQSWRPQPAN
                     KQ"
     CDS             complement(10990..13251)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg258_14"
                     /sec_met_domain="Gly_radical (E-value: 8.7e-42, bitscore:
                     132.2, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate2 (E-value: 2.9e-244, bitscore:
                     802.0, seeds: 33, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQLDETKVPNYWEGFNGGDWQEEINVRDFIEHNLNQYDGDESFL
                     AGPTEATTVLNNQVLNLKKQERANGGVLDADNNIPSTITSHGPGYLNKDLEKIVGVQTD
                     KPFKRAFMPFGGIRMAEDALKSYGFETDANEHKIFTEYRKTHNQGVFDAYTPEMRKARH
                     YKIVTGLPDAYGRGRIVSDFPRIAIYGIDRLMAEKFNDYNLTGDGEMTDDVIKLREEIN
                     EQYRALNDMKKMAKEYGYDISRPAANAQEAVQWIYFGYLAAVKTQNGAAMSVGRIDTVI
                     DAYIQRDMRLGKLNEEQAQELIDHLVMKLRMDRFIRTEEYNSLFSGDPIWATLSLAGMG
                     NDGRHHVTKTAFRFLKTLDNMGAAPEPNITLLWSERLPEGFKRYATEVSIQSSTIQYEN
                     DDLMRNEWGTDYYGIACCVSAQPIADGVQYFGARANLAKTVLYAINGGKDEIQEAQVGP
                     EYEPITSDYIDYDEFMKKFDKMMDWLADVYVNALNVIHYMHDKYYYEAAQLALKDTRLN
                     RTFATGISGLSHAVDSISAIKYGHVKAIRDENGVAIDFVADNDDYPRYGNNDDRADNIA
                     KWLVKTFYNKMNTHHLYRGAKLSTSVLTITSNVVYGKNTGTTPNGRQKGEPFSPGANPA
                     YGAEKNGALASLMSTAKIPYHYATDGISNTFGVTPNTLGHDDETRKDTLVHMVDGYMGN
                     SGMHLNINVFNKETLIDAQKHPEEYPTLTVRVSGYCVYFADLTKEQQDDVIARTFFDEM
                     "
     CDS             complement(13495..15936)
                     /locus_tag="ctg258_15"
                     /transl_table=11
                     /translation="LANQIQELTLEEVMGDRFGRYSKYIIQERALPDVRDGLKPVQRRI
                     LFAMNQDGNTYDKGFRKSAKSVGNVMGNYHPHGDSSIYEAMVRLSQDWKLRAPLIQMHG
                     NNGSMDGDPPAAMRYTEARLSKISKEMLADIDKETVDMVLNFDDTAQEPTVLPAGFPNL
                     LVNGATGISAGYATEIPPHNLREVVNAILYLLKHPQADLADLMQYVKGPDFPTGGIIQG
                     LDGIKQAYETGRGKIVVRSRTHIETIRGGREKIVVTEIPYDVNKAQMIKKIDELRLNKK
                     VDGIAEVRDESDRFGLSVVIELKKEADAHGILNYLFKNTDLQITYNFNMVAIADMQPKL
                     LGLKAMLEAYVAHRRDVVTRRTRYELNKAQARQHIVEGLIKMLSILDQVIAAIRASSDK
                     GDAKRNLVKQFDFSEAQAEAIVSLQLYRLTNTDITALQDEAAQLAKAIAEYQDILAQPA
                     SRDRVIEKELKRIAKEYGDDRRSSIQAEIETLEVATTVTVADETVMVQVSRDGYVKRSS
                     LRSYQAVDPEDNGLKPNDLAIFTGELSTLQHLYIVTNAGNIIYRPVYEISDARWKDTGE
                     HLSQTVGLGTDEKVLAVFAFDQLDLAGTFVLGSSDGYIKQTALSDLQPQRTYKRKPMMA
                     MKLKTPGAVVTNAYFTTDQAQDVFVVSRHAYGLDFPLAEVSTVGARATGVKSMDLKPED
                     EVVNFILVKQPEKAVVGILTQRGAFKRMALSEVGQMSRARRGLLVLRELKRDPHRIVAM
                     MQVDDNTRLDVLTDADKVITLTPVNHPTGDRYSNGSFVIDTDVQGKPVFVRTREETPVE
                     P"
     CDS             complement(15943..16938)
                     /locus_tag="ctg258_16"
                     /transl_table=11
                     /translation="KGKLGTPQARTVVDGIVYDHLATFLMENGEESQELVRKAIKARDA
                     REAARKARDDSRTGRKRKKDQGLLSGKLTPAQTKNPKRNELYLVEGDSAGGSAKQGRDR
                     KFQAILPLRGKVLNTQKAKLQDIVKNEEINTMIYTIGAGVGADFDIQQANYNKIIIMTD
                     ADTDGAHIQILLLTFFYRYMRPLIDAGRVYIALPPLYRLQKGAGAKTKISYAWTDEELA
                     KETKAMGKGYTLTRFKGLGEMNADQLWETTMNPETRTLIRVRIDDAQLAERRVTTLMGD
                     RVEPRREWIEHHVKFDLDDEGSILETPTANHEKLQFGAKQIVKQLDKKRK"
ORIGIN
        1 acaaaccggt caaaatgaaa atacatccga tcggcacacg atctgccagc ggtccgtaac
       61 ccaacatggc caacggataa atcccggtcg acaaaatcgc ccacagcgag aagacccgcc
      121 cgagtttatc cgcaggcaca ttttcctgca agtagatagt ttgcccggcc tgaatcagcg
      181 gataaaagat cccggaaacc aacataaata gcaagtaggt cataaatggt tgaggtaagc
      241 ccatttcggc aaatgcaatt ccgctgcccg caaagccaag cgcaatcaaa ccaagctgat
      301 cccgaaactt tttgtgccgc gcaatgaaca aaccgcctaa cccggcacca attgtccatg
      361 accactcgtt aaacgtcaga tgccagacct ccgaaccgaa tgtacgattg acgtataatg
      421 tcgataattg ggaagaaggg gcaattaaaa taaacgccag tccggtgaag aacataaatg
      481 ccagcaatac cggcgtgtga cccacgtagc gcaatccggc aacaatgcca ttttgctgct
      541 tggttgcttg atccggattg gtaaccggtg ttggcacgtg aacaatccct aagcacaaca
      601 ctgccaatac cgctgtgagc gcgtcgatga caaagatcca aaaaatcccc agatcgctca
      661 aagtataccc ggccagtaac ggcgagatca caagcatagc ggccatcaac atttgattat
      721 atccattcac ccgcgtcagt tgcttttccg gtaccaactg cggcaataac gcgttagccg
      781 ccggattctc cagaccatta ccaaaactgc gaatcaccgc gatgacgagc aacaaccata
      841 gctcttgcgt cacaaacgca aacacataag ctactgcgag ggtcaaaaca gtcacaccga
      901 ctgcagaaat cacaatcagc catttacgat tgtagcgatc ggccaagacg cctgctgaaa
      961 gcgaaattaa aatagctggc aaggcggttg ctaacgaaac ataggtcatc cacgcgccgg
     1021 aagaagtttt tagcgcaata tcccagagca ccgcaaaaaa gacggtggac gttccaaaaa
     1081 caaataaatt ttgacttaag agaaaggcgg cagtttgccc ctgccaccca attttggctt
     1141 gtctcacttt taacacctga aatcagttaa aatagaagct gactttagtt taaagcaatt
     1201 gacttaaaaa gcccacgaat caccacgagg ggagcataac aaacatgccg caaaagattt
     1261 ttattgttga agacgacgat gtgattgcaa agacaattgg taactacctt aatcggtggg
     1321 catttacggt tgaattggtc caaaaattcg atcaggtgga cgctgaaatt cgcgccgccg
     1381 caccggatct ggtgattatg gatattagcc taccgtattt taatggcttc cactggctga
     1441 gcgaattgcg caaacatagc aaggtcccgg ttatcttcct gaccagttct ggggatgata
     1501 tgaatctggt gatggcgatg aatctcggtg cggacgactt tttagctaag ccgatcgagc
     1561 taccggtttt actggccaag attcagggga tgttacggcg aacctaccag taccagcaaa
     1621 ccgataccaa tttaaatcac ggtgagttta cgttggtccc gaccgacaac caactacgct
     1681 cgccgactca agtgatcgac cttacaccga cagagaccaa gttattaagc ctgttatttg
     1741 gtgccgatgg tgaagtggtc acccgagaag cgatgatcga gaagttatgg gaaggcgatg
     1801 agttcattga ccgcaacgct ttggcagtga acatgaatcg gttacggaag aaagtcgccc
     1861 cggtaggact caaccaactg atcgaaaccg tcaaaggaaa aggctatcgc ttggcgaaca
     1921 aggagggcgg ccatgattaa agctttcttg cgcgcccgct ggatggtttg gctgagtctg
     1981 ctcgtcttac tggttgccag tctgttagca aactggctga ttaacgcctc gcttgaagtc
     2041 gcgttaaaca gctggttttt tgcactgatt ccgttacttg tgatcggcgg ctgcgatttt
     2101 tggcggtttc gccgcgaatg gtcgcagctc caaggcgatg ttacactgct tgcggctgat
     2161 caaatttcca atccgcttgg gcaggtttat tttcaaaaaa tccaaatgct gcaacagacc
     2221 ttgcgtcaaa atcatgacac gtatcgtgat caggaacaag aaacggtcga taccttgcaa
     2281 ctgtggaccc atcaaattaa aacaccgctg actgcactgg atctcttatt acaggttgaa
     2341 cctgtcaatg ccagcgatgc gcggcttgaa gttggtaaaa tcaaccgtta tctgaccgtg
     2401 atgctgaatt acctcaaact gaccacactg aatacggatt tggtgttaac cgaattacca
     2461 ctaaaaccgc ttgttaacga aaccgtgcgg gatttagcga aattgtttat tgccaaagac
     2521 ttaacggtca cggtagaaac tttgcccact gtggtgagtg atagtcagtg gctgcgattt
     2581 attttcgagc aattactaac caacgccatc aaatataccc cgcatgggag catccggatt
     2641 tatgccaagg gcgatgccgt gctggtggct gacaccggta tcggcatcct gccagaagat
     2701 ctaccgcgga tttttgaaca aggctattcc ggatacaacg gtcgcgccaa tcaaaaggca
     2761 agtggcttag gcctgttttt aagccggcaa attgcccaga agctggggtt acatctgacc
     2821 gttacatcaa aagtcggtgt cggcagcacc tttgccattc acttcccgca aacgcgctgg
     2881 ctagccgagt aagccacctt accagcttgt aagcaacgca cgctgactgt aagtagtttt
     2941 tcggcagtat cccttttaag ctgataaatg aaaggggcgg atcttatgtc aacattatta
     3001 aagttaaaaa atgtcgaaaa gacttatacc agtcgcggtg cccaaccggt acaggcactc
     3061 gtgaacatca gtttttccgt tgaatcagga gaatttgtcg cgattatggg ggaatccggt
     3121 tcaggcaaaa gtaccttact gaacttaatc gccacgcttg atgatcctac cggcggcgaa
     3181 atcagcctta acggacagga cctgcgcaaa gtcaaagaag gcgcacgggc taaatttcgg
     3241 cgggaacatc tcgggtttat ttttcaggat tttgacttgc ttgacacctt taacgtacag
     3301 gacaacattt tcctgccatt agttttagcc aagaaaccac ttgaaatcat gaaaaatcgg
     3361 ctcacccaac tggcgccgcg tctaggtatc accgatttat tgaaaaaata cccatatgaa
     3421 ctttccggtg gccaacagca acgtgtggcc gctgcccggg cgatgatcac cgagccggaa
     3481 atcctactgg cagacgaacc caccggcgca cttgattcta gaacttccag tgagctgttg
     3541 gacctgctaa ccgatgtcaa tgccgacagt aagcagacaa tcctcatggt gacgcacagt
     3601 gcggttgcag ccagtcatag ccagcgcgtt ttgtttattc gcgatggtca gattttccat
     3661 cagctgtatc gcggtgaatt acagcaaccc gaatttttga cccgaatcag cgaaaccatg
     3721 accgcaatgc tgacgaagga aggcgaggcg caatgaaatt ctatttcaaa ttagccgcca
     3781 ccaaccttaa agccgatcgc cgtttatttg tgccatttgt tatcaccact agctttttga
     3841 tggccatcaa tttgatcatg ctaaacgcct acacgagcag tgatgtattg ttccgccagt
     3901 tcggacaggc agctggcaaa tcactgtttt catttggctc aatgacgacc gcaatcattt
     3961 ccgtcatctt aatcatctac gccaacaact ttttgcgtaa acagcgtatc cgccagttgg
     4021 ggctctacaa catcatcggc tttggcaaac gtgaattaag caaaatgatg gccacggaaa
     4081 agctgctgct attgctgaca accttattgt gcggcgggat tttgggaacc gtgctgtcac
     4141 gccttagcta tctcactttg gccaaaatgc tgcatgttaa tcacaacctc gattttggct
     4201 tgagtcaaac cgccttcagc attgccgggt tgatcacgat tggcttattc attgttttaa
     4261 ttttggttga cgagttctgg ctcttgcgca aacatcccat cgaactcgta cgcgaacaaa
     4321 acgccgggga gcgggaaccg aaaaccaagt ggctaacttt gattgtcagc attgcgagtc
     4381 tggctgccgg ttatacgatt gcggtcaccg tcaagaatcc gcttcaagcg atgagtttgt
     4441 ttttctttgc ggtcgtcctt gtcattgtcg ggacttacgg tctcttcacg tccggctcgg
     4501 tattcgtctt gaaatggctg cgtcaccgca agaactacta ttacaagcct aaacatttta
     4561 tcaacgtctc gaatctgctt taccggatgc agcaaaacgg cgcaggattg gcttcgattg
     4621 ctattttagt caccatgacg ctgattacac ttgcaaccac cgcaacgcta ttctttggca
     4681 ttcatgagat tgtcaactcg caaaccccgg ttgatttagc atactcaatc aaccccaagc
     4741 ggccggatgc agcgaaccaa ctacagacac tggctaaaac atatcacgtc aaaatccact
     4801 cgatgcgaac ctttaccgga ccctcaagta cgcttgcttt attagaaaaa aacaagttag
     4861 attctcaagc taactttaac ggcccgttta gcttcaataa tgcccgttcg gttcagctga
     4921 tgaccgtcga aaattataac cgctatactg gcaagcatgt ggctcttaat catgatgaga
     4981 ttttaatcta tgcctccaat cattaccaac ccgcgacgtt gcgtattggc aaacagactt
     5041 accacgtcgc caaacaagtc accagttttc caaatgcgcc taaaacgttt attcctaact
     5101 tgtttgttgc gctcccatct gatgcacaac tattaaccgc tttacacgcg ctttatccaa
     5161 aaaggtcaat ggcactgctc aaagccgacg tgaccactaa tcaagacgta acattaagcg
     5221 gcagtcacgc caatcaggtc aagctttatc atgcagtcgt caaaagtggg attgcattac
     5281 cggaatcggt tcaatcgcga gccgctaatt acgatgatac tgccagcatg atgagcagtt
     5341 tcctattcct tggggttgtc tttggggtga ccttcatcct ggcaaccttg ctgattcttt
     5401 actacaagca gttggcagaa ggctatgcgg atgcgcgccg ctataccatc ttacaacgcg
     5461 ttggcctgag ccttcgggaa gttcgcgcta ccattaacag tcagctactc acactgtttt
     5521 acctgccttt gatcgtcgct gccatccacg tgggctttgc attgcccttt gtccaacgta
     5581 ttatgatgct attcggcctg ccggattggc aattcttctt aactgtttcg ttaatcacgc
     5641 ttgcaatttt tgcggtcatc tacgtgctga tgtaccgttt gaccggcaac gtttattatc
     5701 gaattgtttc ccgccgtcag ccatccagtc gtgggtgagg gcggtctgac gcatagcata
     5761 aaaaagctgc ctgatcgcaa gccatcaaag gcgatcaggt agcttttttt ctatgtcaac
     5821 cagcatcaaa aaatgtcgca ctgttgtcgc actgttgtcg cactgttgtc tcactgaata
     5881 ctgtgacgtt aattagcgcc gcaacatgac ttaaccagac aactaaccgc cgacattacg
     5941 gttgctgggg atgttgatcc aaggctttgg cggcagtttc cgaaacttcg cgtaaggccg
     6001 cttttccact tttatcgctg agattgatgt acagatccgt agcactggtc gttgtttgtc
     6061 cgagttgatc ggcaacttgc tgcacatcct tggtgacggt ataaatattg gttcccaagg
     6121 tatggcgtgc tttatggggt gttgatgggc ggccataagc ggttgtatag cgtttgaaga
     6181 atgcttcaat cgtattttgg cgaatgcggt tcaccgtttg gccgatttgc gtcacaaata
     6241 gcggagaagt aggcttctgg tgcccaatca tcgcggttcg ggacttcaaa taagccgtta
     6301 aatacggatc aatccagtca gcaaagttaa cgcgatcctg aaaattacct ttacgcacca
     6361 cctgcacagt atgacgatcc atattgagat cttccaaatt catattgacc aattcactaa
     6421 cccgcacgcc ggagccaaac agcagcgcaa tgatcgccaa atttcgttcc ttcgtcgcct
     6481 caaaataagc gcgcggtttc gatggcagct gctgagcata ttgctgatcc agccactgta
     6541 aaaagcgcgc atcttcgcca tccacaaaca acatttcctg cagtttatga ttacggtaag
     6601 tcgtcgtctc cgcatgggtc ttaagtttca ccttattcca aacattgcgg taaaaataag
     6661 gctcaccgtt tgcatttggt tcgctttctt cggttaagaa ccgataaagg gccttgatcc
     6721 cgaccagtcg taacgcaaca ctgcgccgcg tcatgcgttt attcggatgg gttttcgacg
     6781 gccgctcaag taaatacgcc ataaacgcct gcgcatcacg caaggaaagc cgctctaagg
     6841 tctccaaagg cacattctgt ggcgaaacgg catccgtgac ccgactggag ataagccaat
     6901 gcagaaattc ctggtaaaag tgcaggtact ggtaaagggt agaatccgcg atgggaattg
     6961 ctttttggct gtgatagtaa tcctgaatat agtccggcag ggaaggtagc atggcttgta
     7021 ttaatttagg gtagttctgt gtcgacaaat aaagtcacct cgaacatatg ttttcttttg
     7081 gataatttca gtatacgcga aaaaaccagt gcgtggcgag ggataatgac gaaattatcg
     7141 gtaattcgca acgatatgcg ccgaaaaaag caccagtgta gaaatgaata aagttttagt
     7201 attatccaaa ggtaaatgaa cttctaatca tcaagccagc taaatcacca aatttgttga
     7261 tctgtcattt gacactaaac ttagttgcat ttcaaatttg aattcactgc acgatcagga
     7321 catctgtgct gatgtcctga ttccacggcg ccgctttagc aacagtttaa ccaacgattc
     7381 attggctgca atcaaatcaa ttttcgtatt ttgatccaga attcagctga cagcagcatt
     7441 tgcgacttga atgctgttta tgactcaaaa tgatactttc tacaaatctg cgttgattaa
     7501 tgctgaattt caaaactttt ggcatcgact ggccattttc aaaccaaaca accaaaattg
     7561 aagcacaaat ttaacatctg cacagttgat ctgcttctct caaaaatttt tgagccatct
     7621 gtcaggtgag gggaccagca tcaatatttt tgccatttta acaccgaatc attcgcgtcg
     7681 aagtcaacga ttcaaaatct tcattgattc aaaatcttca ttctggttta cataatatat
     7741 attatacgaa gtatttataa ggctgcgttt tttgcacctc gttttaaatt tgaactatcc
     7801 ttactgaaaa atttcgcaat aatcacattt ctgcaccttc agatctagat ctaaaaattc
     7861 gacatttttg ttcatccaag tttttgagca caaaaaaatc gcaaccacaa acggctgcga
     7921 tttataaaac caattattaa gttcaaaatt aaccttcaaa cgcaccttgc attggcggta
     7981 cgacctgctt cttacgtgaa accacgccag gcagtgctaa ccggtcattt gcatcaaact
     8041 tttcgttgaa tgctgcggcc actttgtcac gatctgcgcc aacagcaaag cccgttgaat
     8101 tgctgttcag aatatcggtt gcaattaaca ggaagtcatc atagcccttc gcctgtgctt
     8161 ctttggtcat agcggccacc aattcatcct gacgcgcata aatatcatca agatcaactg
     8221 tattcacttg tccaatacgg atagacttac cacccattgt aaagctcttc gcatcgcctt
     8281 caatgatgtc catatccgac ttggcggcta aattagtgcc cgccttcaac atagccaaac
     8341 cgtatgattg caggtcaatg ccagcgattt tagccatttc cggcaagatc tttttgtcct
     8401 tgtcggtagc agtcggtgac ttcagcagca gcgtatctga aatcaagcca gaagccatta
     8461 agcctgccag tgttggtgaa atttcatagc cgtgttcctg aaacaactcg aaaatcaccg
     8521 tgttggtact gcccactggt tctgcccggt aatatagcgg tgacgccgta tggaagttgg
     8581 caatgcggtg gtgatcaacc actgaatcga tttgcacgtc ttcgatatca gcaacgcttt
     8641 gctggaattc gttatgatca accaacatta cgtgcccggt ttcatttgcg gctgtcttaa
     8701 tgacccgcgg cgcagcaacc ttaaaatgat ccaatacaaa cttggtttca tcgtttggtt
     8761 caccgagtgc tactgcttca acatcggtat tacctgcttg cttctgaaat tcagcccaac
     8821 tcatggcgct ggtaatcgcg tctgtatcag ggttttgatg tccaaaaatc aaagtcgtca
     8881 tgttatctga tcgctcctca gctgaatagt ttaccgttca attttaccac tgttttcgct
     8941 gacccgcgat agataatctt tctcggataa atgcgcgtca aacgtcttaa agaagttggc
     9001 aatccgcgga atatcagctt tttccttgcg atacacaaac gaggtctcaa agcgaatcgc
     9061 tggttcaaag gcaacggcat gcgccttgat ttgatcagca tgagcggcaa caaaactggt
     9121 tggtaacgcg gtgttaacac cggtatggtt gacaaactga gttaactgat atggcgtggt
     9181 aaaatgcgcc acaacatgcg gaaaatcaac catctgattc ttatacgcct catgcaacaa
     9241 ctgacccagg aaatagtcgt ctggataagt tacccacggc tcagccagcg tatctttgaa
     9301 atgcaggcgt ttgcgattag ccaaggaatt atcatgatgc aggaacaata gctgttcatc
     9361 aagaatcttc ttgctggcat acggcttcca gttcttaatc gtctcatcag gcagattcat
     9421 gatggccaaa tcaatctgat tgttctccaa tgcttcccag atctcatgac gtgtcatcat
     9481 tcgtagcgtg atttcgactt cgggattaag gtcgtaataa tgcgcgataa aagtattaaa
     9541 cgcactgtct tcaattgaac ttaacaagcc aatattaatc ttaccgactg tggcactggt
     9601 gctttgctga atctcgtcag tcgtctggtt caaaatttca taaatctcgt gtgtcgcctt
     9661 caacatcgtg cgaccggcat cggataaatg caacttctta ccaacggaat aaaacaatgg
     9721 tgcccccact gttcgttcca atttcttgat ttgctgcgtc agtgccggct gggtaattcc
     9781 caacaactgg gctgactggg tgtagttcat ggtttctgct aattgcaaaa aatacgtgag
     9841 agttttggag gaaaaaatgc gctcttgttt cgtcttcata gggcggcttc cctttcgttt
     9901 ataatttgat aacgttactc aaccatcatc ataagtggca tttaaaaaaa acgcaacgga
     9961 tttgctgcgt ttttaatcgt tacgttaagt ttcaactaaa tcactgcttg ttagctggct
    10021 gtggtcgcca actttgccat ccagtatagt cctcaacgtg tagcaagttc tctgcattct
    10081 tgacccgatc agctgaaggc ggctcaatac cttccagcgg atacgtaata cctagttcat
    10141 ggtacttctt aacccctaac gtatgatacg gaagaatttc cactttctga accacgcgtt
    10201 tatccaaagt ggcaatataa tctcccaagc gcttgagata aggatcaaag tcggttcgtt
    10261 ctggcacaag tacgtggcga atccacatat catcgccatg atccgacata tactgaacca
    10321 tatccaaaat gttttcgttt gggaaaccgg ttagcttttt gtgttccacg gaatcaatgt
    10381 gcttgatgtc aaccaacgaa atatccgtga cggccatcag tttttcaaat tgaccaaacc
    10441 acggctgatc acgggtgaat ggaccacccg aagtatccaa acaagttgag atacccagtt
    10501 ccttagcttt ggtaaaaagt tccaggataa aatcaatttg gacgagactt tcgccaccgc
    10561 tacaagtaat ccccccttgt tcaccccaga aggctttata tcgttgtgca tctgccagga
    10621 tctgatcagc ggtcatttcc tcgcccacac cgatattcca ggtgtcaggg ttgtgacagt
    10681 actggcaccg catcctgcat ccttgcataa agacgacaaa ccgaatcccg ggaccatcaa
    10741 ccgaaccaaa gctttcgact gaatgaacgt atccctttat tgggccttca tgatcctgtc
    10801 ccacttgttc caaaatattt aacgggcttt gtgattgatc gatgagtttc atctatgccg
    10861 cctccagtgc aaataaatac ctaattttca acgattttca tttcagtttg tcaaaaaacg
    10921 gcaacagcat cgttgccgtc ttttgacaaa acaggaatga tctcctgttt tgcgaataga
    10981 ttgacttgat tacatttcgt cgaagaaggt ccgagcgata acatcgtctt gctgttcttt
    11041 ggttaggtct gcaaagtaga cgcagtaacc ggaaactcga acagtcaagg ttggatattc
    11101 ttctgggtgc ttctgggcat caatcaacgt ttctttattg aagacgttga tgttaaggtg
    11161 catgccgcta tttcccatgt agccgtcaac catgtgaacc aaggtgtcct tacgagtttc
    11221 atcgtcatgg cctaaggtgt tcggtgttac cccaaaggta ttgctgatcc catctgttgc
    11281 atagtgatat gggatcttgg cggtcgacat caaggaagct aaagcaccgt tcttttcagc
    11341 gccatacgct gggttggcac caggtgagaa tggttcgccc ttctgacggc cgtttggtgt
    11401 tgtcccggta ttcttaccat aaaccacatt tgatgtaatg gtcagaacgc tagtactgag
    11461 cttagcaccg cgatacagat gatgtgtatt catcttgttg tagaaggtct taaccaacca
    11521 cttagcaatg ttgtctgccc ggtcatcatt gttaccataa cgcggatagt catcattgtc
    11581 agcaacaaag tcgattgcaa cgccattttc atcccgaatt gccttcacat ggccatactt
    11641 gatggcactg atggaatcaa ccgcatgtga caaaccggaa atcccggtag caaacgtccg
    11701 attcagacgt gtatccttca atgccaactg cgcagcttca tagtagtact tgtcatgcat
    11761 gtagtgaata acattcaggg cattgacata gacatctgct aaccagtcca tcatcttgtc
    11821 gaacttcttc atgaactcgt catagtcgat gtagtcgctg gtgatcggct cgtattcagg
    11881 tcccacctgt gcttcctgaa tttcgtcttt accaccgttg atcgcataca gcacggtctt
    11941 ggctaggttt gctcgcgccc cgaagtactg aacaccatct gcaattggct gcgcggaaac
    12001 acagcaagca atgccgtaat agtcggttcc ccattcattg cgcatcagat catcgttttc
    12061 gtactgaatg gttgaacttt ggatggacac ttcagtagca taacgtttga acccttcagg
    12121 aagacgttcg ctccacaaca aggtgatgtt tggttccggt gccgcgccca tgttgtccaa
    12181 ggtcttcagg aagcggaacg cggtcttggt aacatgatga cggccatcat tacccatccc
    12241 tgccaaggac agtgttgccc agatcggatc gccggagaac agtgagttgt attcttcggt
    12301 ccgaatgaaa cgatccatcc gcaacttcat aaccaaatga tcgatgagtt cttgtgcctg
    12361 ctcttcattc agcttgccca aacgcatatc ccgttgaata taggcatcaa tcactgtatc
    12421 gatacggccg acagacattg ctgcaccatt ttgggtctta acggctgcca ggtaaccgaa
    12481 gtagatccac tgaacagctt cttgagcatt agcagctggg cgggaaatgt catagccgta
    12541 ttctttggcc atcttcttca tgtcattcaa ggcacgatac tgttcgttaa tttcttcgcg
    12601 cagtttgata acatcatctg tcatctcgcc atcgccggtc aggttgtaat cgttgaactt
    12661 ctcagccatc agccggtcaa tcccataaat agcaattcga gggaagtccg aaacgatccg
    12721 accgcgacca taagcatccg gtaagccggt cacaatctta tagtggcggg ctttgcgcat
    12781 ttccggcgta taagcatcaa aaacaccttg gttatgcgtc ttacgatatt cggtaaagat
    12841 cttgtgctca ttagcgtcgg tttcgaagcc ataggatttc aaagcatcct cagccatccg
    12901 gataccgcca aatggcatga atgcccgctt aaatggctta tcggtttgga caccgacaat
    12961 cttttcgagg tccttattca gataaccggg accatgagaa gtaatggtcg atggaatatt
    13021 gttatctgca tccagtacac cgccattggc acgttcttgc tttttcagat tcaaaacctg
    13081 attatttaaa acagtcgttg cttcagtggg gccagcaagg aaactctcgt ccccatcata
    13141 ttggttcagg ttatgctcga taaaatcgcg cacgttaatt tcttcttgcc agtcgccgcc
    13201 gttaaagcct tcccaataat taggaacttt ggtttcgtca agctgtttca taggtattgc
    13261 ctcctaaagt gaattacaga tgtgacagtt cttacaaact cagtataaca cgaaggcaaa
    13321 tctatgcaag cgttttatcg ctgatataac aggcgttttg ctgttttttc ggtgtacttt
    13381 cctgtttcat aaaaaaagct taatcattag cttgataagt tgtgcacaac cgtactgtca
    13441 tataataaat caaaaagtcc tcatctgtat taatacagat gaggactttt tgcgttacgg
    13501 ttcaaccggt gtttcttcac gtgtgcgtac gaaaaccggt ttcccttgga catcagtatc
    13561 aatcacaaag gaaccattag agtagcgatc acctgtcggg tggttcacag gcgttaacgt
    13621 gatcacttta tcggcatcgg ttaacacgtc cagacgcgtg ttgtcatcga cttgcatcat
    13681 ggcgacaatg cggtgcggat cacgctttaa ttcgcgtaaa acaagcaatc cgcggcgagc
    13741 acggctcatt tgaccgactt cgcttaacgc catacgttta aacgcaccac gctgagtcaa
    13801 aatgcccact accgcttttt ctggctgctt aactaagata aagttaacca cctcatcttc
    13861 cggtttgaga tccatacttt tgaccccagt agcccgggca ccgaccgtgg aaacttcagc
    13921 cagtgggaag tcgagtccat acgcatgtcg gctgacaaca aaaacatcct gggcttgatc
    13981 ggtcgtgaag tatgcgttgg taaccacggc acccggtgtt ttcagtttca ttgccatcat
    14041 tggcttgcgt ttatacgtgc gctgcggctg caaatcactc aatgccgtct gcttaatgta
    14101 gccgtcactg gagccaagga caaaggtacc agcaagatct agctgatcaa aagcaaagac
    14161 tgccaaaacc ttttcatcgg ttcccaagcc aactgtctgg cttaaatgtt ccccagtgtc
    14221 cttccaccgc gcatcgctaa tttcgtaaac gggccgataa atgatattac cggcattcgt
    14281 gacaatgtaa agatgttgca gggtgcttaa ctctccggta aaaatcgcca aatcattggg
    14341 ttttaaaccg ttatcttcag gatcaacagc ttggtaacta cgcaaggagc tgcgtttgac
    14401 atagccgtcg cgtgatacct ggaccatcac ggtttcatca gccactgtga ccgtcgttgc
    14461 cacttcgagc gtttcaatct cggcttgaat actgctgcgc cgatcatccc catactcttt
    14521 agcaatccgt ttaagttctt tttcaatcac ccgatcacgc gaagccggct gcgctagaat
    14581 gtcttggtat tcggcaatcg ccttggccaa ttgtgccgcc tcgtcttgca aagcggtaat
    14641 gtcggtattc gtcaaccgat ataactgcaa agaaacaatg gcttcagcct gcgcttcgga
    14701 aaaatcaaat tgtttgacca aattgcgttt ggcatcccct ttatctgagg atgcacgaat
    14761 cgcagcaatg acttgatcca aaatggacaa cattttaatc aagccttcaa cgatgtgctg
    14821 ccgtgcctgc gctttgttta actcataacg tgtccggcgt gtgaccacat cacggcgatg
    14881 cgccacataa gcttccaaca tcgccttgag cccaagcaat ttcggttgca tatcggcaat
    14941 cgcaaccata ttaaagttat atgtgatttg cagatcggta tttttgaaga ggtaattcaa
    15001 aattccatgg gcatccgctt cttttttcag ctcaatgaca acacttaagc cgaatcgatc
    15061 actttcatcg cgaacttcag cgataccgtc gacttttttg ttaagtcgta gttcatcgat
    15121 ttttttgatc atttgggcct tgttgacatc atacggaatt tcagtgacca caatcttctc
    15181 gcggccgccg cgaatggttt cgatgtgggt gcgtgagcga acgacaatct ttccccggcc
    15241 ggtttcgtat gcctgcttga tcccatcaag cccttggatg atgccgccgg ttggaaaatc
    15301 gggtccctta acatactgca tcaagtcggc taagtcagct tgcggatgtt ttagcaaata
    15361 caagatagca ttgacgactt cccgcaaatt atgcggcggg atttcggtcg cataccctgc
    15421 agagatcccg gtagcaccgt tgacgaggag attaggaaaa cccgctggca gtacagtcgg
    15481 ttcctgggca gtgtcatcaa agtttaaaac catatcaacg gtttctttat caatatccgc
    15541 cagcatttcc ttactgatct tgcttagccg cgcttctgta taacgcatcg ctgctggcgg
    15601 atccccatcc attgacccat tgttaccgtg catctgaatt aacggtgcgc gtagtttcca
    15661 gtcttggctg agccgcacca tcgcttcgta aatcgagcta tcgccatgag gatgataatt
    15721 acccataaca ttaccgacac tcttagctga cttgcgaaat cctttgtcat aagtgttgcc
    15781 gtcttggttc atcgcaaata aaatgcgtcg ttggaccggt tttaacccgt cacgaacatc
    15841 tggcagtgcg cgttcttgaa taatatattt cgagtaccgg ccaaaccggt cgcccatgac
    15901 ctcttctaag gtcaactctt gaatctgatt ggccaatggc ttttacttcc ttttcttatc
    15961 taattgctta acgatttgct tagctccgaa ttgcaacttt tcatggtttg ccgttggagt
    16021 ttccaagatg ctgccttcat catccagatc aaacttcacg tgatgttcaa tccattcacg
    16081 ccgcggttca acccgatcgc ccatcaatgt cgtaacccgg cgttctgcca gctgagcatc
    16141 gtcaatccga acccgaatca gcgtccgcgt ttcgggattc atcgtggttt cccatagttg
    16201 atcggcattc atttcgccaa ggcctttaaa gcgggtcaag gtatagcctt tgcccatcgc
    16261 cttggtttcc ttagccagct cttcatccgt ccacgcatag ctgattttcg ttttggcgcc
    16321 ggcacctttt tgcaagcggt acaacggcgg cagtgcgata tacacgcgtc cggcatcgat
    16381 taatggccgc atgtatcggt aaaagaaggt caacagcagg atctgaatgt gcgcaccatc
    16441 agtatcggca tcggtcataa taatgatctt attgtagtta gcctgctgga tgtcaaaatc
    16501 ggctccgaca ccggcgccaa tggtataaat catggtattg atttcttcgt ttttgacgat
    16561 atcctgcaac ttggcttttt gcgtattcaa aactttcccg cgtaatggca aaattgcctg
    16621 gaacttacga tcgcgtccct gcttggcaga accaccggcg gaatcccctt cgacaagata
    16681 cagttcgttg cgtttagggt ttttggtctg tgccggggtc agtttaccgg aaagcagccc
    16741 ctgatccttt tttcgtttgc gcccggtccg actgtcatcg cgggctttac gggcggcttc
    16801 acgggcatcg cgggctttga tagctttgcg tacgagttcc tgggattctt ccccattttc
    16861 catcaagaag gtggcaaggt ggtcgtacac aatcccatcg acaacggtcc gtgcctgagg
    16921 cgtccccaac ttgcctttgg
//
