LOCUS       c00200_gnlPro..        15763 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PBFEAGBH_200.
ACCESSION   c00200_gnlPro..
VERSION     c00200_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 18:42:57
            Original ID  :: gnl|Prokka|PBFEAGBH_200
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 899
            Orig. end    :: 16662
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15763
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[10899:15537]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14638
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..15763
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15763
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(315..1310)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_Gly3P_dh_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg200_2"
                     /sec_met_domain="NAD_Gly3P_dh_N (E-value: 1e-33, bitscore:
                     106.7, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLPGKIAIMGGGSWATALAKIVLSTQDSINWYMRRPDQVEEFLL
                     LGHNPSYLSAVKFDTDKIKFYTDINKVIKDSDTLIFATPSPFLKQHLMKVTTSMQDKFI
                     ISAIKGIVPDENMLVADYFAEYYNVPIDNIAVIGGPCHAEEIALERLSYITLACPNIEN
                     ARAFSSVFKNQYLNNSCCKDVTGIEYASVLKNVYAIVAGICHGMKYGDNFLAVFICNAI
                     EEMRNFLNAVHGLERDVTDSVYLGDLLVTAYSRFSRNRTFGTMIGKGYSVKIAQLEMEM
                     IAEGYYGTKCIREINEKYKVNMPILDTLYSILYEKKSPTTAIRQLTETFK"
     CDS             complement(1321..3051)
                     /locus_tag="ctg200_3"
                     /transl_table=11
                     /translation="MNLLELSEQEIIRRNSMEQLRQMGIEPYPAAEYVTNAFSKEIKEN
                     FKDDAEPRPVSIAGRIMSRRIMGKASFMELQDSEGRIQVYISRDDICPEENKDLYNIVF
                     KKLLDIGDFVGIKGFVFRTQMGEISVHAQEITVLSKSLKPLPVVKYKDGVAYDGFNDPE
                     LRYRQRYVDLVVNDGVKDIFMKRAAVIKTMRTALDEAGYTEVETPILQSIPGGASARPF
                     ITHHNSLDIDLYLRIATELYLKRLIVGGFEGVYEIGKNFRNEGMDRTHNPEFTCMELYV
                     QYKDYNWMMSFTEQLLERICIAVNGTCESVVDGKTINFKAPYRRLPILDAIKEKTGYDL
                     NGKSEDEIRTICKDLNLEIDETMGKGKLIDEIFGEFCEGTFIQPTFIIDYPVEMSPLTK
                     MHRSKPGLTERFELMINGKEVANAYSELNDPIDQEERFKEQLRLSEKGDDEAMFIDQDF
                     LRALQFGMPPTSGIGIGIDRLVMLMTGQTTIQEVLLFPQMRPEKTVKKDTADKYVALGI
                     DEAWVPALHKAGYLTTDTLVDANPNKLRQELCEMNKKYKLELQNPTAEEVEAWIAGAAK
                     "
     CDS             complement(3142..3753)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CTP_transf_like"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg200_4"
                     /sec_met_domain="CTP_transf_like (E-value: 2.9e-25,
                     bitscore: 79.4, seeds: 65, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VETGLKENTVSKRKTGIYSGSFNPVHIGHLALANWLCEFTELDEL
                     WFLITPHNPLKEKEELMDDRLRYELVKKSIAGYPKFHASDFEFSLPQPTYTINTLRTLE
                     ASYPDREFYFIMGADNWKYITRWVEYEAIISNYPIFIYPRKGFDVEIPAQYPHIKKVDA
                     PLVEISSTFIREAFKTGKDVRFFLPEAIRNLPFPLQNNTF"
     CDS             complement(3738..3911)
                     /locus_tag="ctg200_5"
                     /transl_table=11
                     /translation="MNGKKLSKKWLYTFIGIAFVALATCTAALYYKEYIIATGTGLVFG
                     AQVINIIKWKRD"
     CDS             complement(3908..4477)
                     /locus_tag="ctg200_6"
                     /transl_table=11
                     /translation="MAGKLIIFSAPSGSGKSTIINFLLKQNLNLHFSISATSRAPRGTE
                     KDGVEYYFLTPDEFRARIAAGDFLEYEEVYTDKYYGTLKSEVERRLMSGDNVIFDVDVV
                     GGCNIKKFYGDRALSVFIQPPSIEDLRSRLEGRGTDAPEVIESRIAKAEFELGFADKFD
                     VIVVNDKLEVAQKEALKVIKEFLKKA"
     CDS             complement(4487..5347)
                     /locus_tag="ctg200_7"
                     /transl_table=11
                     /translation="MTGFGKVTAELPSKKVTVEIKALNSKQLDLSTRIPSIYKEKEMQI
                     RSLLLQSLERGKVEFNIFVEYIGKDTPTQINLAAVENYYNQIKDIADRLNIGLPADWFQ
                     TLLRMPDVIKTEAQEVNEEEWNVVEKAIKEAIGHLCDFRIQEGAMLQKLFEQKIANISR
                     LLSEVEPYEKERIEKIKARIMDNLEKIAGQDYDKNRFEQEMIYYIEKLDVNEEKNRLDN
                     HLKYYISTMESGHGQGKKLGFIAQEMGREINTLGSKSNHAEMQKLVVQMKDELEQIKEQ
                     VLNVL"
     CDS             5583..6302
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M22"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg200_8"
                     /sec_met_domain="Peptidase_M22 (E-value: 1.9e-24, bitscore:
                     76.9, seeds: 111, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSCILNIETSTSVCSVALSMDGEVLFAKASFDGPSHAALLGVFVE
                     EALSVLKKKGKKALDAVAVSSGPGSYTGLRIGVSVAKGLCFGFGIPLIGIHTLDIMAAT
                     VNSKGDSQIVSITDDCLYCAMLDARRMEVYAAIYDASLKPVRETKADIVEAGTYASYLE
                     KGKVCFFGNGASKCKSVITSPNAIFIEDIHPLAVNMIPLSEQAFAAGKFEDTAYFEPFY
                     LKEFQATVAKNKVLLAR"
     CDS             6905..7291
                     /locus_tag="ctg200_9"
                     /transl_table=11
                     /translation="MAHYYVVRQKLDKTGAEDKVRYYGVPVTCGRVSTKKLADLVADRC
                     SLSRGDVFASVCEIGGMILELLKDGYSVELDGLGDFYLSAGSEGFEDPKKCTPHRVKAR
                     RVCFRMAPCVRKSMKFVKFERNPW"
     CDS             7333..9381
                     /locus_tag="ctg200_10"
                     /transl_table=11
                     /translation="MHSRDMEYIVGLLKNGKDAEAILSVRRKLNMAFLARTTDLSGKLP
                     VLAFGSTFKKNGDGIQLRRYNGYVLLEVNGLESQSEAEAVRREAAALPQTLLAFVGLSG
                     RSVKIVVPFVLPDGSLPKKEEQARMFHAAAYQLAVRHYQPQLGSIISLKEPFLSRGCRM
                     SVDPDAYYNPDAVAIRIEQPLQMPDGGDLKIVPSPVRDPLEMMAPGADRNGQIATLFSV
                     ILMEMTRRFSESPEDDIQLLFIDLAQACCRLGIPEEEAVGWTLRYEALKKYKIDIRMAF
                     RTAYTLENVSNRAEPLSSVPPSMSLVLRLDEFMNRRYFFRTNEMSGGVEYLDRSMIQFV
                     YKPYTTKVRNSICLEAQQEGLNVWDKDIDRYVNSDRVPIYHPIDHFLGNLPAWDGKERI
                     RALAGRVPCDNPVWGDLFYRWFLSMVAHWMELDSEHGNSTTPLLVGGQGCGKSTFCLNL
                     LPPVLRPYYTDSIDFGNRRGAELALHRYALINIDEFDSVKSSHQSFLKHILQKAVVNTR
                     LPYQSASRNLRRYATFIATSNNYDLLTDPTGSRRFICVEVKGRIDYAQPIDYDQLYAEA
                     KELLRRGERFWFTPEEEALITENNRDFQQQPAEEQLFLRYFKIAEDIEEAKPLLASEIL
                     DMIAEKQPGFNITKTMILNFGKLLKRNSVPNKRTMRGTCYYVEEVDG"
     CDS             9662..9808
                     /locus_tag="ctg200_11"
                     /transl_table=11
                     /translation="MRRKNTNVLLVFGVVIAIILLMIWLFLGTTLEQEANPETDPMTVE
                     QNI"
     CDS             complement(10001..11197)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg200_12"
                     /sec_met_domain="OAD_beta (E-value: 2e-153, bitscore:
                     500.6, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLGSVLLQAAGTAHESFLQFLGENLELFLTYTGVYNATPGHLIMI
                     LVGLLFIFLAIKYEFEPMLLIPIGFGILIGNIPFKDAGLQVGIYEQGSVLNILYQGVTS
                     GWYPPLIFLGIGAMTDFSALISNPKLMLIGAAAQFGIFGAYIIALQMGFEPNQAGAIGI
                     IGGADGPTAIFLSSKLAPNLMGAIAVSAYSYMALVPIIQPPFMRLLTTQKERLIRMKPP
                     RAVSSTEKIVFPIVGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLAETARGPLIDT
                     ITILLGITVGASTQATQFLTLNSIKIFGLGALSFVIATCAGILFVKFFNLFLKEGNKIN
                     PLIGNSGVSAVPDSARISQNVGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLG"
     CDS             complement(11202..11633)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 65.5; E-value:
                     9.6e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg200_13"
                     /sec_met_domain="Biotin_lipoyl (E-value: 2.6e-21, bitscore:
                     65.5, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSFKYTINGNVYKVHISSVVDDIAEVEVNGTPYQVKMEKPAKKQ
                     MVTLKRPAQAPTTASGEPVISRPAASTTKGAVKSPLPGVILQVNCKVGDTVKRGQNLLV
                     LEAMKMENNINADRDGKIIEIKVNKGDSVLEGADLVVIG"
     CDS             complement(11656..12543)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg200_14"
                     /sec_met_domain="OAD_gamma (E-value: 1.4e-12, bitscore:
                     38.3, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINKKIGVLLLFALLVSFGAKAQRATSMRINEVLVINEDNFVDDY
                     GKRHAWIELFNNSAGSVNIAGCYLTNDKSNPKKYPIPKGDVLTVIPPRQHTLFWADGEP
                     DRGTFHVNFTLDPSKENYIALYDADGKTLIDEIVIPASQKADVSYGRTLDGQGEWTALT
                     KVTPSTNNVTLDSNEKIENFKENDSWGIGMTLTAMAVVFSGLFLLFIIFKQIGKLSIAA
                     SKRNAQKAAGAAVIADNAGQESGEIFAAIGAALYEMSDDNHDIEHTVLTIRKVQRSYSP
                     WSSKIYGLREVPKK"
     CDS             complement(12565..14118)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg200_15"
                     /sec_met_domain="CT_Btheta (E-value: 2e-292, bitscore:
                     960.0, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKVKELIALRETARLGGGEKRIESQHKKGKYTARERIAML
                     LDEGSFEEFDMFVQHRCTNFGIEKTKYLGDGIVTGYGTIDGRLVYIYAQDFTVFGGALS
                     EALAMKICKVMDQAMKMGAPVIGLNDSGGARIQEGVNALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFNIMTRGTSYMFLTGPKVVKTVTGEDVTQEQLGGASVHTT
                     KSGVAHFAVDTEEDGLQLIRKLISFLPQNNLEETPLIECKDPIDRLDDNLNDIIPDNPN
                     QAYDMYEVIGTIIDNGEFLEVHADYAKNIIVGFARFNGQTVGIVANQPKVMAGCLDSNA
                     SRKAGRFVRFCDAFNIPLVTLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTV
                     TLRKSYGGAYCVMSSKHLRGDMNYAWPTAEIAVMGPSGAVEVIFAKEVAASEDPKACAA
                     EKEAEYKKAFANPYNAAQYGYIDDVIEPRNTRFRIIRALQQLQTKKLSNPAKKHDNLPL
                     "
     CDS             complement(14231..14638)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg200_16"
                     /sec_met_domain="Glyoxalase_4 (E-value: 1.9e-27, bitscore:
                     85.9, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELTHIEHLGIAVKSIEACLPYYEEVLGLKCYNIEEVADQKVKTA
                     FFKVGQTKIELLEPTSEDSTIAKFIEKKGEGIHHIAFAVPDVQAALDEAESKGVKLIDK
                     APRGGAEGLNIAFLHPKSTCSVLTELCMPGK"
     CDS             complement(14783..15763)
                     /locus_tag="ctg200_17"
                     /transl_table=11
                     /translation="DNKLESTRISGYLQDVFKFRTKQGLFTLVGGVRGSYWSYNREFIF
                     SPRASIGFIPNFDQNLTFRLASGLYYQSPFYKELRTTVQDEHGNSIIQLNKNLKSQRSI
                     HVIAGGDYTFRASGRNFKVSADMYYKKLDNLNPYTVDNVKIRYYGENCAQGHAMGLDVK
                     FFGEFVPGTDSWISFSLMKAEQSIRGSEYVPMPNSQGYNVSLFFQDYFPGYKRVKLNLK
                     GVLSGGLPVTAPRTGYEDGYFRTPTYKRVDLGFSYQLAGGTDAIMDRGFFRNLKNIWLG
                     LDIFNLFDIKNTSSYYWITNIDNHQYAIPNYLTGRQLNIRLIVDF"
ORIGIN
        1 accagtcgaa gctattgttt aatgcttcta ccactgcttt tgttcctaaa tagctgccgc
       61 cgataccgat ggcgacaaca acttcacatt tggaacgaag tacgttagct gtattttcga
      121 tgtctgtcag ttcagcatct gtaatagaag aggggaggtg caaccaacct aaaaagtcgt
      181 tacctgcacc attaccattt tgtaaagtgg cattacattc gtgggccttt gcagcctgag
      241 catatacctg ttctttcgtt acggtaccca gcgctttgtc aatgttaaga ctgatgttct
      301 tcatatttac attattattt aaatgtttca gtcaactgcc gtatcgcggt agtcggcgat
      361 ttcttttcgt atagaatact atataaagta tccaagatcg gcatgtttac tttatatttt
      421 tcgtttatct cccgaataca ttttgtcccg tagtatcctt cggcgatcat ctccatttcg
      481 agctgggcta ttttgacgga ataacctttc ccgatcatgg tcccgaacgt acggttccgg
      541 ctgaagcgag aatatgcggt taccagaaga tcaccgagat ataccgaatc tgtcacatcc
      601 cgttccaggc catgtacggc gttgaggaag ttacgcatct cttcgatcgc gttgcagatg
      661 aaaactgcca gaaaattatc tccgtacttc ataccgtggc agatacctgc gacgatagca
      721 tatacgtttt tcaatacgga agcatattca atacctgtaa catccttgca acaggagttg
      781 ttcagatact ggttcttaaa tacggaggag aaagctcttg cattctcgat attagggcaa
      841 gccagcgtga tataggacaa ccgttcgaga gcgatctctt cggcatggca cggaccgccg
      901 atgacagcga tattgtcaat cgggacattg tagtattcgg caaaataatc ggctacgagc
      961 atgttttcgt ccggaacgat tcctttgatg gccgaaatga tgaatttgtc ttgcatggag
     1021 gtcgtcacct tcatcaaatg ttgtttcaaa aaaggagaag gggtggcgaa aatcaaagtg
     1081 tccgaatctt tgattacttt gttgatatcc gtgtagaatt tgattttgtc agtatcaaat
     1141 ttgacggcgg aaagatagct ggggttatgt cccaacaaca gaaactcttc tacttggtct
     1201 ggccgacgca tataccagtt aatactatct tgtgtagaaa gtacaatctt ggctaaggcg
     1261 gtagcccagc taccacctcc cattattgca atttttccgg gcaacttcat agtattactc
     1321 ttatttggct gcgcctgcaa tccatgcctc tacttcttcg gcagtggggt tttgcaattc
     1381 cagtttgtat ttcttattca tttcgcagag ttcctgtctc agcttgttgg gattagcatc
     1441 taccaacgtg tcggttgtga gatatccggc tttatgtaaa gcaggaaccc atgcttcatc
     1501 gatacccagt gcgacatatt tgtctgcggt gtctttctta actgtctttt ccgggcgcat
     1561 ctgcgggaag agcaacactt cttgaatagt tgtttggcca gtcatcaaca tcaccagacg
     1621 gtcgatgccg ataccgatac cagacgtcgg aggcataccg aattgcagtg cacgcaaaaa
     1681 gtcctggtcg atgaacatcg cttcgtcatc tcctttttcg ctcaggcgca attgctcttt
     1741 gaagcgctct tcctgatcga tcggatcgtt cagctcacta taggcatttg ccacttcttt
     1801 accgttgatc atcaattcga aacgttcggt caatccaggt ttgctccggt gcatcttggt
     1861 tagcggactc atctcgaccg ggtagtcgat aatgaaagtc ggctggataa acgtgccttc
     1921 gcagaattca ccgaagattt catcgatcag cttgccttta cccattgttt catcgatttc
     1981 aaggttcaaa tccttgcaaa tcgtgcgtat ctcgtcttcg ctcttgccat tcaggtcgta
     2041 acctgtcttt tccttgatgg catccagaat cggcagacgg cggtaaggag ctttaaagtt
     2101 gatggtcttg ccgtcgacta cactttcaca tgtaccgttg acggcgatac agatacgttc
     2161 caacagctgt tcggtgaagc tcatcatcca gttgtagtcc ttatattgga cataaagttc
     2221 catacaggta aattccggat tgtgggtgcg atccatacct tcgttacgga agtttttacc
     2281 gatttcgtag acaccttcga aacctccgac gatcaatcgt ttcagataca gttcggtagc
     2341 aatacgcaga tagaggtcga tatccagcga gttatggtgc gtaatgaacg gacgtgcgct
     2401 tgcccctccg gggatggatt gcaggatcgg agtttccact tccgtatatc cagcttcgtc
     2461 cagcgcggta cgcatggtct tgataactgc cgcacgtttc atgaaaatat cctttacgcc
     2521 atcattgacc accaggtcga catagcgttg gcgataacgc aattccggat cgttgaatcc
     2581 atcgtatgct acaccgtctt tgtatttgac gaccggtagc ggcttgagtg atttggataa
     2641 taccgttatc tcttgtgcat ggacggaaat ttcgcccatc tgtgtacgga atacgaaacc
     2701 tttgattccg acaaagtcgc cgatatcgag caatttcttg aaaacaatgt tatacagatc
     2761 tttattttct tccgggcaaa tgtcgtcacg agagatataa acctgtattc tgccttctga
     2821 atcctgcaat tccatgaagg aagcctttcc catgatgcgg cggctcatga tgcggccggc
     2881 aatacttacg gggcggggct ctgcatcgtc tttaaaattc tcttttatct ctttggaaaa
     2941 tgcattcgtt acatactcag ctgcgggata aggttctatc cccatctgac gtaactgctc
     3001 catgctgtta cgtcttatga tttcctgttc actcagttct aatagattca ttacgctatt
     3061 attttgtata atacggcgca aaaatacaaa acttttctta cttattgcct aaaaacgtat
     3121 gcgactttac gctttatgtt cttaaaaggt attgttttgt aatggaaaag gcagattacg
     3181 tatggcttcg ggcaggaaga agcggacatc ttttccggtc ttgaaagctt cgcgtataaa
     3241 ggttgaggat atttcgacca aaggggcgtc tacttttttt atgtgaggat attgtgccgg
     3301 aatttcaaca tcgaatcctt tacgcggata gatgaagatc ggataattgg aaatgatggc
     3361 ttcgtattct acccaccggg taatatattt ccaattgtcc gcacccatga tgaaatagaa
     3421 ttcacggtcc ggataacttg cttccaatgt ccggagtgtg ttgatggtat aagtgggttg
     3481 aggaagggaa aactcgaagt cactggcgtg gaacttaggg taaccagcga tggatttttt
     3541 aaccagttca tagcgaagcc ggtcatccat cagttcttcc ttctctttta gcgggttatg
     3601 gggggtgatc agaaaccata gctcgtccag ctccgtaaat tcacacaacc agttggctaa
     3661 tgccagatgg ccgatatgaa ccggattgaa tgaaccggaa taaatgccgg ttttacgttt
     3721 gctgaccgta ttttctttca gtcccgtttc cacttgatga tatttatgac ttgtgcaccg
     3781 aataccaatc cggtaccggt cgctatgata tactccttat aatatagggc ggctgtacaa
     3841 gtggcaagag cgacaaatgc tataccaatg aatgtatata gccatttctt ggataacttc
     3901 ttgccgttca tgctttttta aggaactctt ttatcacttt tagtgcttct ttttgtgcga
     3961 cttccagctt gtcgttcacc acgattacgt caaatttgtc ggcaaaaccc agttcaaatt
     4021 cggctttggc aatgcggctt tcgattactt ccggagcatc cgtaccgcgt ccttccagac
     4081 gactccgcaa atcttcgatc gaggggggct ggataaagac cgaaagagca cggtcgccat
     4141 aaaacttctt gatgttgcaa cctcctacga catcgacatc gaatatgacg ttatcgccac
     4201 tcatcagcct tcgttccacc tcgcttttca gcgtgccgta atatttgtcg gtatagacct
     4261 cttcgtattc caggaaatct cctgctgcta tacgggcacg gaattcatcc ggtgtaagga
     4321 aataatattc cactccgtcc ttttccgtac cacgtggggc ccggctggta gccgagatgg
     4381 aaaaatgcag gttcagattc tgcttcagca ggaaattgat gatagtggat ttgcccgaac
     4441 cggacggcgc ggagaatatg atcagtttgc cagccatata tcgtttttat aatacgttta
     4501 atacttgttc tttgatttgt tccagttcgt ctttcatctg gacgacaagt ttttgcatct
     4561 cggcatggtt gcttttcgaa ccaagggtgt tgatttcacg tcccatttcc tgggcgatga
     4621 aaccgagttt cttaccttgt ccgtgtccgc tctccatcgt gctgatgtaa tatttcaggt
     4681 ggttgtccag gcggttcttt tcctcgttta catccagttt ttcgatataa tagatcatct
     4741 cctgttcgaa ccggttcttg tcgtagtcct gtccggcaat cttttcgaga ttgtccatga
     4801 tacgggcttt gattttttcg atccgctcct tttcatacgg ttctacttct gaaagcaggc
     4861 gggagatatt ggcaattttc tgttcgaaca acttttgtaa catggcgcct tcctgaatac
     4921 ggaaatcgca aaggtgccct atggcctctt tgatcgcttt ctcaaccaca ttccattcct
     4981 cttcgtttac ttcctgggcc tctgtcttga tcacgtccgg catgcggagc agggtctgga
     5041 accagtcggc gggaagtccg atgttcaggc ggtcggcaat atctttgatt tgattgtaat
     5101 agttttctac cgcagccaag ttgatctgtg tgggcgtgtc tttaccgata tattcgacaa
     5161 atatattaaa ttcgactttt ccacgttcaa gcgactggag taacaaactg cgtatttgca
     5221 tttctttttc tttgtagatg gaaggaatgc gggtcgacaa atccagttgc ttgctgttca
     5281 gagcttttat ttctacggtt acttttttag aaggaagttc ggctgtaacc ttaccgaatc
     5341 cagtcattga ttgtatcatt gttctaaaaa tttgtgcaaa gatagctaat caattgataa
     5401 ttgacaattg acgattgaca atataattga gaaaaagccg aaaccatccg tgtcagcctt
     5461 aataaaatcg gttttgatca tgagattaca gttatgtttt atacttttgc atccattatc
     5521 aaccgattgg cttttgacac atattttaat tgtcaattgt caattgtcaa ttgtcaatta
     5581 aaatgtcttg tatattaaat atcgaaacat cgacttctgt atgctctgta gcgttgtcta
     5641 tggatggtga agtccttttt gcgaaggcct cgttcgacgg cccttcgcat gcagccttat
     5701 taggcgtatt tgttgaagaa gctctttccg tattgaaaaa gaaggggaag aaagccttgg
     5761 atgccgtagc ggtcagtagc ggtcctggtt cttataccgg actccgtatc ggagtgtctg
     5821 tcgctaaagg tctttgcttt ggtttcggta ttcctctgat cggcattcat acgttggaca
     5881 tcatggctgc tactgtcaac agtaagggtg attcgcaaat cgtctctatt actgatgatt
     5941 gcctttattg tgctatgttg gatgcccggc gtatggaggt ttatgccgct atctacgatg
     6001 cttccttaaa gcctgtccgc gagacgaagg ccgatattgt ggaagccggt acgtatgctt
     6061 cttatctgga aaaagggaaa gtttgtttct ttggcaacgg tgcttccaaa tgcaaatcgg
     6121 tcatcacttc tccgaacgcc atctttatcg aggacatcca tcctcttgcc gtaaacatga
     6181 ttccgctctc ggaacaagct tttgccgccg gcaagtttga agacaccgcc tatttcgaac
     6241 cgttctacct gaaagagttc caggcgacgg ttgcaaaaaa taaggtgctt ttagctcgat
     6301 gatgtagttg tgtgctatgt cggaatggca cgtttgtcga aatttttatg taagtccggt
     6361 caatcggaaa agaacttaga tatgcaaaat cgtcctgttt cttgtgtttg atagctgcaa
     6421 tgtcaaacat ggaaacagga cgatgtgtta tttagggttg ccatccatgt aagtcttcct
     6481 cctgcaagca atataaataa actgctgtaa acatccacct attatataca tatgattttt
     6541 tttaaatcca actatcatac tatcatattt tcttataaat gtctgtatat tagtttataa
     6601 aaatatgata gtatctattt tcaactatca tttcatacta tcatactatc atgtcgtata
     6661 tcacatgctt ctgtcttcgt gctggggaaa aataagtgta gatataattg aataaagtgc
     6721 tgtaaatatt tgcattatag atgttttatt tgtatatttg taataagaaa agaagcccgt
     6781 catccgggtg tcggaagggg tgagacccgg gtgttgatac cgttcagatg ggggtgtcaa
     6841 aagtgttaaa atgggcgtct tgagaagaat atctggttgt ttaatattaa aaatactgtt
     6901 atttatggca cattactatg tagtccggca aaaactggac aagacgggag cggaagataa
     6961 agtacgctat tatggtgttc cggttacgtg cgggcgggtt tcaacgaaaa agctggctga
     7021 tttggttgcc gatcgttgct cgttgagccg aggtgatgtg ttcgcttcgg tttgcgagat
     7081 cggagggatg attcttgaat tgttgaaaga cggctattcc gtggagttgg acgggttggg
     7141 tgatttttat ctgtcggcag gaagcgaagg cttcgaagat ccgaaaaaat gtactcccca
     7201 tcgggtgaag gcgcgtcgtg tctgtttcag gatggctccc tgtgtgagaa agagcatgaa
     7261 atttgtcaaa ttcgaaagaa atccttggta atgcaaatca catattacag gcataaaaaa
     7321 ggcgtgttgc ggatgcactc gcgtgatatg gaatatattg tcgggttgct gaaaaacggc
     7381 aaagatgcgg aagcgatact gtcggttcgt cgaaaattga atatggcgtt tttggcacga
     7441 accacggatt tgtccggaaa actaccggtc ctggcttttg gctcgacgtt caagaagaat
     7501 ggcgatggaa tacagttgag gcgctataac gggtatgtct tgttggaagt gaacggcttg
     7561 gaaagccaga gtgaggcgga ggccgtccgc cgtgaagctg ccgccctgcc gcagaccttg
     7621 ctggcgttcg tcgggctgag cgggcgttcg gtcaagatcg tggttccttt tgtgctgccc
     7681 gacggctcgc tgccgaaaaa agaggagcag gcccgtatgt ttcatgctgc ggcttatcag
     7741 ctggcggtgc ggcattacca gccgcagttg ggcagcatta tatcgttgaa agaaccgttc
     7801 ctgtcgcggg ggtgccggat gagtgtggat ccggacgcct attacaatcc ggatgcggtg
     7861 gcgatccgga tcgagcaacc tttgcagatg ccggacgggg gtgacttgaa gatcgtgcct
     7921 tctccggttc gggatccgtt ggagatgatg gctccgggag cggatcggaa cgggcagatc
     7981 gccacgctgt tcagtgtcat cctgatggag atgacgcgtc ggttttcaga aagcccggaa
     8041 gatgatatcc aactgctgtt catcgacttg gcgcaggctt gctgccggct tggaataccg
     8101 gaggaagagg cggtgggctg gacattgcgc tatgaagctt tgaaaaaata taagatagac
     8161 atccgtatgg ctttccgtac ggcatatacg ttggagaatg tttcaaaccg ggcggagccg
     8221 ctctcttccg tcccgccatc catgtcgttg gtgttgcggt tggacgagtt tatgaaccgg
     8281 cgttatttct tccggacgaa tgagatgagc ggtggagtgg aatatttgga ccgttcgatg
     8341 atacagttcg tttacaagcc ttatacgacg aaagtccgga attccatttg cctggaagcc
     8401 cagcaggaag ggttgaatgt atgggacaag gatatcgacc gatatgtcaa ctccgatcgt
     8461 gttccgatat atcatcctat cgatcatttt cttgggaatc ttccggcttg ggacggaaaa
     8521 gaacgcatca gggcattagc cgggcgtgtc ccttgtgaca atccggtatg gggagatttg
     8581 ttttaccgct ggttcctaag catggtggca cattggatgg aactggattc ggaacacggg
     8641 aatagtacga cacctctgtt ggtcggtggc caagggtgtg ggaagtccac gttttgcttg
     8701 aatttgttgc caccagtgtt gcgtccttat tatacggaca gtatcgattt cggcaatcgc
     8761 cgtggggcgg agttggcttt gcaccggtat gcgttgatta atatcgatga atttgattca
     8821 gtgaaaagtt ctcatcaaag ttttttgaag catatcctgc aaaaagcggt tgtgaacacc
     8881 cgtttgcctt atcagagtgc gagccgtaac ttgcgtcgct atgccacgtt tatcgcgacc
     8941 agcaacaatt atgatttgct gacagatccg accggtagcc gccgtttcat ttgcgtggag
     9001 gtgaagggcc ggatcgatta tgcccagccg atcgattatg atcagttgta tgcggaagcg
     9061 aaagaattgt tgaggcgtgg tgaacgtttt tggtttactc cggaggaaga ggcgctgatc
     9121 actgaaaaca acagggattt ccagcagcag ccggctgaag agcaactgtt cctgcgttat
     9181 ttcaagattg cggaggatat tgaagaggca aagccgcttc tggcgtccga gatactggat
     9241 atgatcgcgg agaaacaacc cggttttaac attacaaaaa cgatgatcct taatttcggc
     9301 aagcttttga agcggaatag cgtgccgaat aagcggacga tgagggggac ttgttattat
     9361 gtggaagagg tagatggttg atatataatt gattgactaa ttttatgtat gatggtatga
     9421 tagtagccat gacagttgtt ttgcgaactg tcatggctat tttgtgttga tatatagtgg
     9481 gttattgcca attatgatgg tatgatagtt ggatcgtcta tttccaacta tatttgtaag
     9541 tgaagaaaaa acattctttc taaaatattt actcagttaa ataaagaaca aaagtaagga
     9601 acggttaaac caaaaaaggg ggtgtcttgt ttaatcttca aatcaatatt gaagaataga
     9661 catgagacga aagaatacga atgtactgct ggtctttggt gtggtgatcg cgattatcct
     9721 gttaatgatt tggttgtttt tggggacaac attggaacag gaggcaaatc cagagacaga
     9781 tccgatgacc gtcgaacaaa atatctgata aggtcggata taaaaaggga ggctgtgtcg
     9841 taaatagttt tttatgatac agccattaat atacttctga tgaatcgttg tgcgcatata
     9901 caaacttacc caagaatacg ttaaaatccg taaacttggg taagttttta tatttggaga
     9961 tgacttggag ttcagctcct ttttatgtag aataagtgga ttatcctaag aatcccaaca
    10021 ggataccggc tgctacggca gaaccgatta cacctgctac gttcggaccc atggcgtgca
    10081 tcaacaggta gttggtcgga tcatattcca gacctacgtt ctgagagata cgggcagagt
    10141 cgggcacggc agacacaccg gagttaccga taagcggatt gatcttattg ccttctttca
    10201 agaacaggtt gaagaacttc acgaacagga tacctgcaca agttgcgatc acgaatgaca
    10261 acgctcccaa accgaagatc ttgatggagt tcaatgtcag gaactgggtt gcttgagtag
    10321 aagcacctac cgtaatacct aacaggatcg tgatcgtatc gatcagcgga ccacgggctg
    10381 tttcagccaa acgacgtgtt acaccacttt ctttcaacaa atttccgaag aacagcatac
    10441 ccaacagagg cagaccggaa ggaacaagga agcaagtcag caacaggcct acgatcggga
    10501 atacgatctt ttccgtggaa gaaacggctc tcggcggttt catgcggatc agacgttctt
    10561 tctgagtcgt cagcaggcgc atgaacggag gctggataat aggaaccagc gccatataag
    10621 agtatgccga tactgcaata gcacccatca agttcggagc taacttggaa gaaaggaaga
    10681 ttgctgtcgg gccgtcggca ccaccgatga taccgattgc accggcctgg ttcggttcaa
    10741 atcccatttg aagagcgatg atatatgctc cgaaaatacc gaactgagcc gctgcaccga
    10801 tcaacatcag tttaggattg gagatcaatg cggagaaatc ggtcatggcc ccgataccga
    10861 ggaagatcaa cggcggatac catccggagg ttacaccctg gtagaggatg ttcagcacag
    10921 aaccttgttc gtaaataccc acctgcaatc ctgcatcttt gaacggaatg ttaccgatca
    10981 ggataccgaa tccgataggg ataaggagca taggctcgaa ttcatattta atagccagga
    11041 agatgaacaa cagaccgaca aggatcatga taaggtgacc cggtgtcgcg ttgtagactc
    11101 ctgtataagt gaggaacaac tccaagtttt ctcccaagaa ctggagaaag ctttcatgag
    11161 ccgtacccgc tgcctgtaat aatactgatc ctaacataat attatcctat tacgacgagg
    11221 tcagcacctt ccagtacgga atcccctttg tttactttta tttcaatgat tttgccgtca
    11281 cggtcggcat tgatgttgtt ttccatcttc atggcttcga ggacaagtag attctggcct
    11341 ctcttgacag tatcaccgac tttacagtta acctgcagga ttacacctgg cagcggagat
    11401 ttgacagcgc ccttggtggt tgaggctgcc ggacgggaaa taaccggttc gccacttgcc
    11461 gttgtaggag cttgagccgg gcgtttcagt gtaaccatct gtttttttgc cggtttctcc
    11521 atttttactt gatagggagt accgtttact tctacttcag cgatgtcatc cactaccgag
    11581 ctgatatgta ctttatatac gttaccgtta atagtatatt taaaactttt cattcttgtt
    11641 tgtttttaga gataattact ttttgggaac ttcacgcaga ccgtaaatct tggaactcca
    11701 cggagaataa gatctttgaa ccttgcggat cgtcagaacc gtatgttcga tgtcgtggtt
    11761 gtcgtcgctc atttcgtata gagccgcacc gatagccgca aagatttccc cggattcctg
    11821 acctgcattg tctgcaataa cagccgctcc ggccgctttc tgtgcattgc gtttgctggc
    11881 cgcgatcgag agctttccga tttgtttaaa gatgatgaac aacaggaata atccggagaa
    11941 cacaactgcc atggcagtca gggtcatacc gataccccaa gaatcatttt ctttaaagtt
    12001 ctcgattttc tcgttagaat ccaatgttac gttattggtg ctgggtgtaa cttttgtcag
    12061 agcagtccat tcaccttgtc cgtctaaagt tctaccatag ctgacatctg ctttttgtga
    12121 agcagggata acgatctcat cgatcagagt tttaccgtct gcatcgtata acgcaatgta
    12181 attttctttt gatgggtcga gcgtgaaatt gacatggaat gttccccgat ccggttctcc
    12241 gtctgcccag aacaaagtgt gctggcgagg aggaattact gttagaacgt cgcccttcgg
    12301 aatcggatac tttttcgggt tgctcttgtc attagtcaag tagcaaccgg cgatattgac
    12361 cgaaccggcc gaattgttga acaattcgat ccaggcatgg cgtttgccgt aatcatcaac
    12421 aaagttatct tcgttgatga ccagcacttc atttattcgc atggaggttg cacgctgtgc
    12481 ttttgctccg aatgaaacga gcaacgcgaa cagcagcaat acccctattt tcttattaat
    12541 catattcatt tcctgtttta agaattatag aggcagattg tcatgtttct tggcaggatt
    12601 gcttaacttc ttggtctgca attgttgtaa agcacgaata atacggaaac gagtgttacg
    12661 aggttcgata acatcgtcga tatagccata ttgagctgca ttgtatgggt ttgcaaatgc
    12721 ttttttgtat tcggcttctt tttctgcagc gcaagctttc ggatcttccg aggcagccac
    12781 ttcttttgca aagatcactt ctacagcgcc gcttgggccc ataactgcga tttcggctgt
    12841 cggccatgcg tagttcatat cgccacgcag atgtttggag ctcatcacac aataggctcc
    12901 accgtaagat ttacgcaatg ttacagttac tttaggcact gtggcttcgc cgtaagcgta
    12961 aagcaatttg gctccgtgca ggataacgcc gttgtattcc tggcctgtac ccggtaagaa
    13021 tcccggtacg tcaaccaatg taaccaaagg aatgttgaaa gcatcacaga aacggacgaa
    13081 acggcctgcc ttgcgggagg cgttgctgtc cagacagcct gccattactt tcggctggtt
    13141 ggctacgata ccgacagtct ggccgttaaa acgggcgaaa ccgacgataa tgttcttggc
    13201 atagtcggca tgtacttcca gaaattcgcc gttatcgatg atggttccga taacttcata
    13261 catatcgtaa gcctggttag gattgtcagg gatgatgtcg ttcaggttgt catccagacg
    13321 gtcgatcggg tctttacatt cgatcagagg agtttcttcc aggttgttct gcggcaggaa
    13381 gctgatcaat ttgcggatca actgtaaacc gtcttcttcc gtatcgactg cgaagtgggc
    13441 cacaccggat ttggtcgtat gtacgcttgc gccacctaat tgttcctgtg taacatcttc
    13501 gcctgtaact gtttttacta ctttcggacc agtcaggaac atgtaacttg ttccgcgggt
    13561 catgatattg aagtctgtca gggcaggaga gtaaaccgca ccgccggcac atggaccgaa
    13621 gataccggaa atctgaggaa taaccccgga agccaagatg ttacgttgga agatttctgc
    13681 ataaccggcc aaggcgttga caccttcctg gatacgtgcg ccacccgagt cgttcaagcc
    13741 aataacggga gcacccattt tcatcgcctg atccattact ttacagatct tcatggccag
    13801 tgcttcggat aaagcaccgc cgaacacggt gaaatcctga gcataaatat ataccagacg
    13861 tccgtcgatc gttccgtaac ctgttacgat accgtcgccc aaatacttag ttttttcaat
    13921 accgaagttt gtacaacgat gttgtacgaa catatcgaat tcttcaaaac ttccctcatc
    13981 cagcaacatg gcaatacgtt cgcgtgcggt gtatttacct tttttgtgct gagattcgat
    14041 tcttttttct ccaccaccta aacgagctgt ttcgcgaagg gcgataagct cctttacttt
    14101 ttcaagttgg ttactcattg tactatagat ttgttgttag aaatgaactt atttaattgg
    14161 caattgacga ttgagaattg acaattgaat agcatcaaat aattgtcaat tctcaattgt
    14221 ccattgtttc ttattttccc ggcatgcaaa gttcggtcag aacgctgcat gtcgatttcg
    14281 ggtgaaggaa tgcaatgttc aagccttctg cacctccacg aggagctttg tcgatcagct
    14341 tgacaccttt tgattcggct tcgtccaatg ctgcctgtac gtcgggaaca gcaaatgcaa
    14401 tgtggtggat accttcacct ttcttttcga taaatttagc gattgtactg tcttcacttg
    14461 tcggctccag caactcgatc ttagtctggc ctactttaaa gaatgcagtt tttactttct
    14521 ggtctgctac ttcttcgatg ttgtagcatt ttagtcctaa aacttcttca taatacggca
    14581 ggcaagcttc gatgctcttt actgcgatac ccaaatgttc gatatgtgta agttccatgt
    14641 caataataat ttagtaattt aatattgctt tttgttctat gttggcaaag gtacactctt
    14701 tttattaata gagaaataat tcgttaatat ttatcagcat gatccggata tgtttaaaaa
    14761 gcatattttt gaaatcatgt ggttaaaaat caacgataag tcgaatattc aattgtcttc
    14821 cggtcaggta attagggatt gcgtactggt ggttgtctat attggtaatc caataatagg
    14881 aactagtgtt ctttatgtcg aacaagttga aaatatccaa tccgagccaa atgttcttga
    14941 gattgcggaa gaatccgcga tccatgattg catccgttcc cccggcaagc tggtaggaga
    15001 aaccgaggtc cacgcgtttg taggtcggag tacggaaata gccgtcctcg tagcctgtac
    15061 gtggggctgt gacgggaagg ccgccggaca gtacgccttt cagattcaat ttgacacgtt
    15121 tgtatccggg gaaataatcc tgaaaaaaga gcgagacatt ataaccttgg ctgttaggca
    15181 tcggtacata ttcgctccct cggatgcttt gctccgcttt cattagggag aagctgatcc
    15241 aggagtccgt acccggaaca aattcgccga agaatttgac atcgagcccc atcgcatggc
    15301 cttgtgcaca gttctcgccg tagtatcgga ttttgacatt atccaccgta taggggttca
    15361 ggttatccaa ttttttataa tacatatcgg cactgacttt gaaatttctg ccggatgccc
    15421 ggaatgtata atcgcctcct gcaatgacat ggatggaacg ctgtgatttc aggtttttgt
    15481 tcagttgtat gatactgttg ccgtgttcgt cctgcacagt tgtacgtaat tccttataga
    15541 acggagactg ataatacaga ccggaagcca gccgaaatgt caggttctgg tcgaagttcg
    15601 gaatgaaacc tattgaagca cgcgggctga atataaattc cctgttataa ctccaatagc
    15661 tgccgcgtac accaccaacc agcgtgaaca gtccttgttt ggtacgaaac ttgaatacat
    15721 cctgcaaata gccggaaata cgtgtgcttt ccagtttgtt atc
//
