LOCUS       c00044_gnlPro..        15022 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HMOBBPNF_44.
ACCESSION   c00044_gnlPro..
VERSION     c00044_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 12:41:12
            Original ID  :: gnl|Prokka|HMOBBPNF_44
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15022
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15022
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1582:5022]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1583..5022
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..15022
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15022
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             2..217
                     /locus_tag="ctg44_1"
                     /transl_table=11
                     /translation="LRRVNDFSFFIFVDFYEVNLFQDETMISAYHFIYIIDSMTFVLSI
                     DQLLHFLVDILLSLFLAGNQYLCPRH"
     CDS             228..1259
                     /locus_tag="ctg44_2"
                     /transl_table=11
                     /translation="MKIGTIDLGERPVFLAPMEDVTDISFRLMCKRFGADMVYTEFVSA
                     DALIRSVNKTQQKLNVADEERPVAIQIYGRDVPTMVEAAQICEAAHPDILDINFGCPVK
                     RVAGKGAGAGMLRNIPLMLDITREVVKAVNIPVTVKTRLGWDADNRIIVDLAEQLQDCG
                     IAALSIHGRTRAQMYTGEADWTLIGEVKNNPRIQIPIIGNGDVTSAEICKQRFEQYGVD
                     AVMIGRGSIGRPWIFREVRHYLDTGETLPAESFSWYLDILKKQVEQSVERLDERRGILH
                     IRRHLAATPLFKGIADFKQTRVAMLRAETVEALFDILDSIPDKFHTGYGFQSDSQVSES
                     IDC"
     CDS             complement(1232..1390)
                     /locus_tag="ctg44_3"
                     /transl_table=11
                     /translation="MKKTHCKYKVYLLNTQEFVITFYCKFATFCFKIDTVCGFTLLLYQ
                     QSIDSDT"
     CDS             complement(1583..2338)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg44_4"
                     /sec_met_domain="Fer2_3 (E-value: 1.1e-25, bitscore: 83.0,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_8 (E-value: 3.3e-11, bitscore: 36.8,
                     seeds: 153, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 3.5e-05, bitscore: 17.5,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKDIKVTLKVWRQKGPKDKGQFETYQIDKINQSVSFLEMLDILN
                     ERLVSEGKEPIVFDHDCREGICGMCSLYVNGHPHGPATGATTCQLYMRRFNDGETITIE
                     PWRSAGFPVIRDLMVDRYAYDKIIQAGGFVSVNTGGVPDANAIPISKADADLAMDAAAC
                     IGCGACAAACKNGSAMLFVSAKVSQLALLPQGKVEAARRAKAMVAKMDELGFGNCTNTR
                     ACEMECPKNISVSNIARLNREFISAKLQD"
     CDS             complement(2366..4309)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 194.4; E-value:
                     1.1e-59)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg44_5"
                     /sec_met_domain="FAD_binding_2 (E-value: 2.7e-59, bitscore:
                     194.4, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 1.8e-37,
                     bitscore: 121.5, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQIDSKIPQGPLAEKWTNYKNHQKLVNPANKRRLDIIVVGTGLA
                     GASAAASLAEMGFNVLNFCIQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTIKG
                     GDYRAREANVYRLAEVSNSIIDQCVAQGVPFAREYGGLLDNRSFGGAQVSRTFYARGQT
                     GQQLLLGAYSALSRQIGLGKVKMYTRHEMLDVVKVDGRARGIIARNLITGKIERFAAHA
                     VVVATGGYVNTFFLSTNAMASNGSAAWQCYKKGAYFANPCMVQIHPTCVPVKGDFQSKL
                     TLMSESLRNDGRIWVPKKLEDAKALQAGTKKGKDIPEADRDYYLERRYPAFGNLVPRDV
                     ASRAAKERCDAGFGVNSTGLAVFLDFSDAINRLGKEVVKQKYGNLFDMYEEITNDDPYE
                     TPMMIYPALHYSMGGLWVDYELMTSIPGLFAIGEANFSDHGANRLGASALMQGLADGYF
                     VLPYTIQNYLSDQIQVPRFSTDLPEFVEAEKAINARIAKLMNVKGKETVDSIHRKLGHI
                     MWEHVGMARDAEGLKEAIQMLKDLKKEFWSNVFIPGEANSLNVELDKALRLADFIEIGA
                     LMAHDALDRAESCGGHFRTEHQTEEGEAMRHDDKFMYVSCWEYQGEDKDPVMLKEDLNY
                     QFVVPQTRNYKK"
     CDS             complement(4348..5022)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg44_6"
                     /sec_met_domain="SucD_FumR (E-value: 1.1e-66, bitscore:
                     217.4, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWLLNSSIGKKLIMSISGLFLILFLVFHLCMNIAAVFSGEAYNVI
                     CGLLGSNWYALLGTLVLAAGVVVHFVYAIILTLQNRKARGNDRYAINARPKGVEWASQN
                     MFVLGVIVILFMVLHFTQFWYNMMFAELAGIHGDIHPQDGAAFINFYFQGNVVNTVLYL
                     IWFVALWFHLTHGFWSAIHTIGWNNTVWLSRWECISKWVATIICGLFAVITVIFYLNGV
                     GA"
     CDS             5282..6235
                     /locus_tag="ctg44_7"
                     /transl_table=11
                     /translation="MKTAIFSIGVFLISLFLGSCQPSEISCSVVDTGKTLDYKIGDKLL
                     FSYNYTTVYPAPGVDSVYKRSGFIHPLKTLRGEVMTNCSPADHYHHFGLWYAWTKTTFE
                     GNEIDFWNLHKKQGTVRFRNFEHVSDNGFVATLDHVVYPDSPAEKVAMNERLEINIGTT
                     SLPGYYIDYHTTIRLASPSPITMEAYRYGGICIRTREDWNDQTAEMLTSEGLSRDEADG
                     SRARWCYYQGKAGNEKACILIVASPSNLNYPEPLRVWDKTVNKPAGDVMWNFSPTKQKA
                     FTLEPGKELSLSYRIYVLDKNINATTAEVLSDFERD"
     CDS             7292..10573
                     /locus_tag="ctg44_8"
                     /transl_table=11
                     /translation="MLKKTKLVSLMLLAGTLAVPESAFAEITPERPSVSLSQQNGKVVC
                     VVEDPFGPVIGASVVVKGTTNGNVTDMDGKVVLENLKKGDIIQISYIGYATQEITYTGQ
                     PSIPVTLKEDTQALQEVVVVGYGTQKKENLTGAVAAVAGDVLENRPITNVGQGLQGVVP
                     NLNVTMSKGGAPGSSSDFNIRGNNSINGGSPLVLVDNVQMDANLVNPEDIASISVLKDA
                     ASAAIYGARAAYGVILITTKKGKSEQKPQISVSASGYWQSPALRMHNINSLEYLEMRDI
                     AAANSGMSSLITPGQLDYVKKYMDGSYKYSEYFDQSQDQSRWIYCGNTDWFNELYKTSF
                     SQQYNVNISGGDSKTTYYGSVGFADQNGILKTADDNYKKFNATLNLSSQLTKWLQVSAK
                     IADNYSTEDHPITNSTAGIDAYGGMLKNDLSPLMPVRFGHTGRLVYSPGAAAINDSNLG
                     IQTSGDYIYKEEGINNYSGQNGNTNPAAVGDLGGYTKYKINDLWLTGAVKITPLEGLVI
                     NADYTYNIYSKNASEVQRTFTDYTAVAGTEALYGWTKPSYANYTTNEDYYYAFNAFAEY
                     SKSFLENTHNFKIMAGYNQEKKSNKKYNAKRTNLIVEDIPDLDLATGEQSMSSEDTYWA
                     INGFFFRFNYNYKQRYLLEVNGRYDGSSKFAKDHRYAFFPSVSAAWRISEENFWQPLKG
                     WWNDMKIRGSYGSLGNQVMDDLGNFPYLATYGTNSSYNYLINGSKPVIVKAPGLVAPDF
                     TWETVTQMDFGFDASFLNNRLTGTFDWYRRNTKDMLVAGATLPATLGASVPKSNSADMK
                     TIGWELSLGWNDRLENGFSYWVKGVLSDYQATITKYAGNDAGFYSQSDGDGKYYVGQKI
                     GEIWGYHSNGLFQSDDEAATIDQSELYAGKWGAGDVKYEDLDNNGKITKGEETIYNPGD
                     KSIIGNKTPRYQFGITVGFDYKNFDFEMFWQGTGKRDYMLSGAQFWGFTSQWDVPYTPA
                     LDYWTETNTDAYFPRPGWQNGGNRVTSDRYLQSAAYGRLKNLTVGYTIPKNLTTKWGIS
                     RLRLYVTGENLLTITPLNDAFDPETLGGMTYPINRKVAIGLNLTL"
     CDS             10584..12443
                     /locus_tag="ctg44_9"
                     /transl_table=11
                     /translation="MTMKTKHILLGLSLGLLGGFTACDVTDLNPKDSITDNSYWNTVSD
                     LENYAKGFYMNLTGKGLRADGSENLDDLNTLDERSDNRLVASPDQWLFNEWVIPSEANF
                     DSKWYWNNIRNLNYFMTRYQRVNATDSEVNPVVAVIRFFRAFDYFDKIKTFGDVPWYEK
                     DLTTADIDELYKARDDRDFVLGKIIEDLEFAIEWLPEKSAAEVGALHKDAARTFLARVC
                     LHYGTYKKYHNVSTSPTSQELLQKAATLAKEVMDSGLYDIVQGSDAGANQSAFADYPLY
                     YANQFTQEDLTTNKECILARVFEADVLTHNLARGGGVGLSKDFAESFLCKDGLPIANSS
                     EYKGDETLDDEMANRDPRMYQIIDSKYRPYTVKSNGMRVVNSGIDDKKEFSPSEEPGTN
                     VHSAPGLTGTATGYSPIKLVSASQSQQDAVKTSSYDWFVFRYAEILLIYAEAKCELGEC
                     TQAVLDETINKLRDRVEMKHLTVSPVADLNPVDYGYSITPLLYEIRRERRIELALEGFR
                     YDDIMRWNAMKLFENPKTYLGMRVTDKVKALYQPEVFEGSTARDLIEYNGKTYIRMYSG
                     KSLNEAGRKWTGNDKRLYYPIPTSQITLSASHGSLLKQNPGWE"
     CDS             12644..14404
                     /locus_tag="ctg44_10"
                     /transl_table=11
                     /translation="MNKKDLILNILLFISQIIVFYYFFCYLFPFKEQLQMFQFTSQYLT
                     ETLKQAGGVAIYISEFLSQFYVVFWTGPIISALLLTLVALLSSLILKKINSRNDLPLIF
                     LLPWLSLLIISLDYDYYEQGTIAYLFLLLFLWLYTNIKTRIKFIYGICIIPILYGIAGP
                     IVHLFAISALFFEFLTNGKKKYISIIYLLIAALSAIAGTYLGYSRNLTLAFLPEAYCNP
                     LQTVSGIYYAWYALPMTMLLVAYLKRYKEPVSLKGKCIWEGAQWAIMFLLVYQGIFHFG
                     KLDAQHSMKQDYLLRTEQWDLVISEFNHDVLSKRRMCGLNLALAHKGQLSERLLDYPQH
                     GIETLMLHWDQSIYTAQLHSDLYYCMGIISAAQKFAFEAFVSSRSSGNPRMLKRLIETN
                     LITGSYPIADKYIQLLEKTWFYKDWATAHRRFLYNDKAVEEDKILGMKRRCWKAEASAA
                     KLYTDPVSSLINLLPACPDNKAGLAYLTSFLLLNKDIETYKTLQESLYRSPAWRDMTEC
                     QQEAIVICSPNDPHFWLEHGVSIKVRNRAIAFMQKVQDVSRSGQNLAVALASEYGKTYW
                     YYYMFNMMDK"
ORIGIN
        1 cttgcgacga gtcaatgact tctctttttt catctttgtt gacttttatg aagtcaacct
       61 atttcaggac gagacaatga tttcagctta tcattttatc tatatcattg acagtatgac
      121 atttgtactt tctattgatc aattactaca ctttttagta gatatccttt tatccctgtt
      181 tttagcagga aatcagtacc tttgtccccg tcattgataa tataaatatg aaaataggta
      241 caatagattt aggcgaacgc cccgtcttct tagctccgat ggaagacgtt acagatattt
      301 ctttccggtt gatgtgcaaa cgttttggtg ccgatatggt ttataccgaa ttcgtttcag
      361 cagacgccct gatccgcagt gtaaataaaa cacagcaaaa gctgaatgtg gcggatgaag
      421 aacgtccggt cgccatacaa atatatggcc gtgatgttcc gacaatggtc gaagccgcgc
      481 aaatttgcga agccgctcat ccggacattc tcgatatcaa tttcggttgc cctgtcaaac
      541 gagtggcagg caaaggagca ggcgccggca tgctgcgcaa tattccactg atgctggaca
      601 tcacccgtga agtcgtcaaa gcggtgaaca tccctgtcac cgtaaaaacc cgcttgggct
      661 gggatgccga caaccggatc atcgtagact tggccgaaca gctacaggat tgcggtatcg
      721 cagccctttc catccacgga cgtacccggg cacagatgta cacaggagag gcagactgga
      781 cactgatcgg tgaagtaaaa aacaatcccc gcatacaaat tcccatcatc ggcaatggcg
      841 atgtgacttc cgccgaaatc tgcaaacaac gtttcgaaca atatggcgtg gatgccgtta
      901 tgattggccg gggcagcata ggccgcccct ggattttcag agaagtgagg cattatctgg
      961 atacaggcga gacattgcct gccgaatctt tttcatggta tctggacata ctgaaaaagc
     1021 aggtggaaca aagcgtggaa cgtttggatg agcgccgggg aattctccac attcgccgcc
     1081 atttggctgc aactccgctg tttaaaggta ttgcagactt caagcagaca cgcgtcgcca
     1141 tgctacgtgc ggaaacagtg gaagcattat tcgacattct ggattccatc cccgacaaat
     1201 ttcatacagg atacggattt caaagcgact ctcaagtgtc agaatcgatc gattgttgat
     1261 ataataacag tgtgaatccg cacacagtgt caattttaaa acaaaaagta gcaaatttgc
     1321 aataaaatgt aattacaaac tcttgcgtat tcagtaaata tactttatat ttgcagtgag
     1381 tttttttcat agtattttag atctaaggtt aacaaagtct ttgcagagag ggaatcgaga
     1441 gactgtttca ctggaaagca acaaaaaagc cgcatccact tttattatag ggagtgcggc
     1501 ttttttgtgg gtttgaacga acataaagaa agcccgttgc cattggcaac gggcttttcc
     1561 atatacatac atatataatg tattagtctt gtaacttagc agagatgaac tcgcggttca
     1621 agcgagcgat gttgctaacg gagatgttct tcggacattc catttcgcaa gcgcgagtgt
     1681 tcgtacagtt accaaagccc agttcatcca tcttagcaac cattgctttt gcacggcgag
     1741 cagcttccac cttaccctga ggcaaaagag ccagctggct aacctttgca gagacgaaca
     1801 gcatagctga accgttctta caagcagcag cacaagcacc gcagccgata caagcagcag
     1861 catccatagc caaatccgca tcagccttag aaataggaat tgcattagca tcaggaaccc
     1921 cacctgtgtt tacagaaacg aaaccacctg cctggataat cttatcataa gcataacggt
     1981 ctaccatcaa gtcgcggatt accgggaaac cagcagaacg ccacggctcg atcgtaatcg
     2041 tctcaccatc attgaaacgg cgcatataga gctgacaggt tgttgcacct gttgccggtc
     2101 cgtgcggatg tccgtttaca tacaatgaac acataccgca gataccttca cggcagtcgt
     2161 ggtcgaatac gataggttct ttaccttcgc taaccaaacg ttcattcaaa atgtctaaca
     2221 tttccaagaa agaaacactc tgattgattt tgtcgatttg gtaagtctca aactgtcctt
     2281 tatctttcgg acctttctga cgccaaactt taagtgttac ctttatatct ttatccatga
     2341 ttctaatttt tgtgattgat gattattact tcttgtagtt acgtgtttga ggaacaacga
     2401 actgatagtt caaatcttcc ttcagcataa ccgggtcttt gtcttcaccc tggtattccc
     2461 aacaagagac gtacatgaac ttatcgtcat gacgcatagc ttcgccttct tcggtctgat
     2521 gttccgtacg gaagtggcca ccacaagatt ctgcgcggtc taacgcatcg tgtgccatca
     2581 atgcaccgat ttcgataaag tcagccaaac gcaatgcctt gtccaattcc acgttcaagc
     2641 tattggcctc acccggaatg aatacattgc tccagaattc cttcttcagg tctttcaaca
     2701 tctggatagc ctctttcaaa ccttccgcgt cgcgtgccat accgacgtgt tcccacatga
     2761 tatgtcccag cttacggtgg atagaatcga ctgtttcttt acccttcacg ttcatcaact
     2821 tcgcgatacg agcgttaata gccttttctg cttccacaaa ttcaggcagg tcagtgctga
     2881 agcgcggaac ctggatctgg tcagacagat agttctggat cgtgtaaggc aatacaaagt
     2941 aaccatcagc caatccctgc atcaaagcag aagcacccag acggttagcg ccgtggtcag
     3001 agaagttggc ttcaccgatt gcgaacagcc ctggaataga agtcatcaat tcatagtcta
     3061 cccacaaacc acccattgag tagtgcaatg caggataaat catcatcgga gtttcatacg
     3121 gatcatcgtt cgtgatctct tcgtacatat cgaacaggtt accatatttc tgtttaacca
     3181 cttccttacc cagacggttg atagcgtcgg agaaatccag gaataccgcc aagcccgtgc
     3241 tatttacacc gaaaccggca tcacaacgtt ctttagcggc acgtgaagcc acatcacgag
     3301 gaaccaagtt accgaatgcc ggataacgac gttccagata gtagtcgcga tctgcttcag
     3361 gaatatcctt tccctttttt gttccggcct gcaatgcctt cgcatcttcc agcttcttcg
     3421 gaacccagat gcgaccatcg ttacgcagtg attcagacat caaagtcagt ttagactgga
     3481 agtcaccttt cactggcaca caagtcgggt ggatctgcac catacaagga ttagcaaagt
     3541 aagccccttt cttgtagcac tgccatgcag cagaaccgtt agacgccatc gcgttagtag
     3601 acaagaagaa tgtatttaca taaccacctg tcgcaacaac gactgcgtga gcggcaaaac
     3661 gttcgatctt accggtaatc aaattacggg caataatacc gcgagcacgt ccgtcaacct
     3721 tcacaacatc cagcatttca tggcgtgtgt acatcttcac ctttcccaaa ccaatctgac
     3781 ggctcaatgc agagtaagca cccaacagca gctgctgtcc ggtctgacca cgggcataga
     3841 acgtacggga tacctgagca ccaccgaatg aacggttatc caacagacca ccatattcgc
     3901 gagcgaatgg tacaccctgt gctacgcact ggtcgataat agagtttgac acttcagcca
     3961 gacgatagac gtttgcttcg cgggcacggt agtcaccacc tttgattgta tcgtagaaca
     4021 gacgataaac cgagtcacca tcattctgat aattctttgc cgcattgata ccgccctgtg
     4081 cagcgataga gtgtgcacga cggggagagt cctgaataca gaaattcaat acattgaatc
     4141 ccatttcagc cagagaggca gcagcagaag cacccgccag accagtacct actacaatta
     4201 tgtccaaacg acgtttgttt gcgggattca ccaatttctg gtgattttta taatttgtcc
     4261 acttctcagc caacgggcct tgaggaattt tagaatctat ttgagtcata atgttttatt
     4321 ttcaaattga aaaaataata tccgaaatta agcacctaca ccgttcaggt agaagataac
     4381 tgtgataaca gcgaataagc cacaaataat agtggcaacc catttagaga tacattccca
     4441 acggcttaac caaacggtat tgttccagcc aattgtgtga atcgcagacc agaaaccgtg
     4501 agtcaggtga aaccacagag caacgaacca gatcagatac aacaccgtat tcacaacatt
     4561 gccctggaag tagaaattga taaacgctgc accatcctgc ggatgaatgt caccatgaat
     4621 acctgccagt tcggcaaaca tcatgttgta ccagaactga gtaaagtgca gaaccatgaa
     4681 caggataacg atcacaccca aaacaaacat gttctgagaa gcccattcaa cacctttcgg
     4741 acgagcgttg atggcataac ggtcgttacc gcgagcctta cgattctgca gagtcaagat
     4801 aatagcatac acgaagtgca cgactacacc tgcagccaac accaatgtac cgagcaaagc
     4861 ataccagtta gaacccagca aaccgcaaat cacgttatac gcttcaccag aaaatactgc
     4921 cgcaatgttc atacataagt ggaacaccaa gaacagaatg agaaaaagac ctgatatact
     4981 cattatcagc ttcttcccga tagaagaatt aagtaaccac ataagataat aatttaagtt
     5041 atttaattgt atttagaaat ttcctccaat ctatggttat tatcgtgcaa aggtatgcta
     5101 aatccccata tcacgcaaac gattaaagaa atatttcatc aattagaacg ctgcttgctg
     5161 gctggtttta tttgcatcag atatcacaaa cggattgtgc gaaacgaaaa aatttcgttt
     5221 ttttgtagcc gatacaggca aggtcttgcc ggataactga ttattattta attgtcatat
     5281 tatgaaaact gctatttttt ctattggtgt ttttttgatt tctctgttct taggctcttg
     5341 tcagccttcc gaaatatcct gttccgtcgt cgacacgggg aaaaccttag actataagat
     5401 aggagataaa ctgttgttct cttacaacta taccacggtt tacccagccc ctggcgttga
     5461 ctcggtctat aaacgcagcg gtttcatcca tcctttgaag acattgagag gcgaagtgat
     5521 gaccaattgt tctcccgccg accattacca tcatttcggt ttgtggtatg cctggacgaa
     5581 aaccacgttc gaaggaaacg agatcgattt ctggaatctc cacaaaaaac aaggaacagt
     5641 tcgcttccgc aacttcgaac acgtatccga caacggtttt gttgcgacac tggaccatgt
     5701 ggtctacccc gattctcccg cagaaaaagt agcaatgaac gaacgcctgg agatcaacat
     5761 cgggacaaca tccttaccag gttattacat cgactatcat accactatcc gcctcgccag
     5821 ccccagcccg atcaccatgg aagcttaccg ttatggcggc atatgcatcc gtacgcgcga
     5881 agactggaac gatcagacag ccgaaatgct cacctcggaa ggcctttccc gcgacgaagc
     5941 tgacggttcg agagcccgtt ggtgctacta ccaagggaaa gccggaaacg aaaaggcctg
     6001 tatcctaatc gttgcctccc cttccaacct gaactatcct gagcctttac gcgtatggga
     6061 caaaacagtc aacaagcctg ccggtgacgt catgtggaat ttctcaccga ccaagcagaa
     6121 ggcattcaca ttggaacccg gtaaagaact gagcctgtct taccgcattt atgtattgga
     6181 caagaacatc aacgctacta cggcagaagt gctgtccgat ttcgaacgtg attgaatttc
     6241 tactaaaaca aactgacaat ttgcagggca aggtaaacaa gaaaaggaaa aagggcttgt
     6301 tctcctatat catcaaagcc aaggctcttt tatgtaaata cagctacaaa tcaatgagaa
     6361 acacgtaata aaacttaccc aacaccccca tgtatccgcc cccgacaccc ggatcttacg
     6421 ctcttataga tccgggtgtc gggggcggat acatgggggt gttggtgaaa ttgtctccct
     6481 acttttacct taaaatgctt ggagtttatt catttaaaac agatagatga gcgattacag
     6541 atagtgatag aagcgtgata tataaaacag gtatctatca ctttagatac gcactgatta
     6601 tcaagactca cacgacattt agtgatagag tgacagatgt tcatgaaaaa acatccaaga
     6661 aatcacccca tcccgactac tgagcttcaa taaagttaca ctaaaattag ataaattaac
     6721 acaggcattg tatttcattg cctattgccc ttttcccagt ttttcgacag atacaaaatc
     6781 atgttctgtg ctgatgagaa tatgcataac cacaaaactt tcagacaaat atgcaatatt
     6841 ataaaaataa gattattttt tgaccaccca tgcacagaaa gagatataag ttctatcaga
     6901 actcatgtat ttatgaagaa atgtatctga taagtgtgaa tattgtacaa aaatagagtt
     6961 gaatgataag ccgcaaatta cttcttgtgc ttaaaaaggt tcaaaagtct gatattgtct
     7021 gatgcttgtt gatagcctgt aagtctgaat tgttaaaaat gagtgctata tgaacttttt
     7081 taataaaaaa acatacaacg aaatgaaaat ttcatacctt tgacccggat atgagataat
     7141 taaaaaccat agttctgata gaactaaatt acaaaaacac agaaaaacgc tataaaaata
     7201 tgcaaaatct aatgagcatg atctaataaa gacactcaac agatgtaagc cgttttcgtg
     7261 gtatgtatta tttcttttaa atatatactc tatgttgaaa aaaactaaat tagtaagtct
     7321 gatgctactg gcaggaactt tagctgttcc agaaagtgct tttgccgaaa ttactccgga
     7381 aaggccgtca gtaagtctat cccaacaaaa tgggaaagta gtatgtgtgg tggaagatcc
     7441 gttcggccct gtgatcggag cttcagttgt tgtaaaagga acaaccaacg gaaatgtgac
     7501 agacatggac ggcaaagttg ttttggaaaa tttgaagaaa ggagatatta ttcaaatttc
     7561 ttacattgga tacgcaacac aggaaataac ctatacagga caaccgtcaa tccctgtaac
     7621 attaaaagaa gatacccagg cgctacaaga agtagtagta gtaggttacg gtacacagaa
     7681 aaaagagaat ttgacaggtg ctgtggcagc tgttgccggt gatgtactag aaaaccgtcc
     7741 tataacaaat gttggacaag gattacaagg tgttgttcca aacttaaacg tcaccatgag
     7801 taaaggtggt gctcctggta gtagctctga ctttaatatt cgtggtaaca actcgattaa
     7861 cggtggtagc cctttagtgt tagttgataa tgttcaaatg gatgccaacc ttgttaatcc
     7921 ggaggacatc gcgtctattt ctgttttaaa ggatgccgca tctgctgcta tctacggtgc
     7981 ccgcgctgct tatggcgtta ttttaattac aacaaagaaa ggtaaaagtg aacaaaaacc
     8041 tcagatttcc gtatcagcaa gtggttattg gcagagccct gcattaagga tgcacaatat
     8101 caactctttg gagtatctgg aaatgagaga tattgctgcc gccaatagcg ggatgagttc
     8161 cttgatcact ccaggacaat tagactatgt aaagaaatat atggatggct cttataagta
     8221 ttcagaatat ttcgatcagt cgcaagatca aagtcgatgg atttattgtg gcaacactga
     8281 ttggtttaat gaattgtaca aaacaagttt ctctcaacaa tataatgtaa acattagtgg
     8341 tggagactca aaaacaactt attacggctc tgtcggattt gctgaccaga atggtatttt
     8401 aaaaacagct gatgataatt acaagaaatt taatgcgaca ctgaatcttt cttcacaact
     8461 gacaaagtgg ttgcaggtca gtgccaaaat cgcagataat tattcaacag aggatcaccc
     8521 cattaccaac tctacagcag gaatcgatgc ctatggaggt atgttgaaaa atgacttaag
     8581 cccgttaatg cctgtacgtt ttggccatac aggaagactc gtttatagtc ctggcgcagc
     8641 agccatcaat gattctaact taggtatcca aacttcaggc gattatatct ataaagaaga
     8701 aggtattaac aactattcag gtcagaacgg gaacacaaat cccgctgctg taggagattt
     8761 aggcggatat accaaatata aaatcaacga tttatggttg acaggtgctg taaaaatcac
     8821 tcctttggaa ggattggtta tcaatgctga ttatacatat aatatttata gcaagaatgc
     8881 atcagaggtt caacggacat ttacagatta tacggctgta gctggaacag aagctcttta
     8941 tggttggaca aagccaagtt atgcaaatta tactacaaat gaagattact actatgcatt
     9001 caatgcattt gcagaatatt ctaaatcatt tttagaaaat acgcataact ttaagattat
     9061 ggccggttat aaccaagaaa agaaatccaa caaaaaatat aatgcaaaac gtaccaatct
     9121 gattgttgaa gatattcctg acttggattt ggcgacaggt gaacaaagca tgtcttcaga
     9181 agatacatat tgggcaatta atggtttctt cttccgcttc aattacaatt acaaacaacg
     9241 ttatctactc gaagttaacg gccgttatga cggttcatcc aagtttgcaa aagatcatcg
     9301 ttatgcattc ttcccatctg tttccgcagc atggcgtatc tcagaagaaa atttctggca
     9361 gccgttaaaa ggttggtgga atgatatgaa aatccgtggt tcttatggtt cattgggaaa
     9421 tcaggtaatg gatgatctag gtaatttccc atatttagca acatatggga cgaattcttc
     9481 ctacaattat ttgattaacg gatccaaacc tgttattgta aaagcaccgg ggcttgtcgc
     9541 tcctgatttt acttgggaaa cagtcactca aatggacttc ggttttgatg cttcatttct
     9601 gaataatcga ctgacgggaa catttgactg gtatcgtaga aatacaaaag acatgttggt
     9661 agccggagca actttacctg caacattggg cgccagtgtt cctaaaagta actctgctga
     9721 catgaagacc ataggctggg aactttcttt aggatggaat gatcgattag aaaatggatt
     9781 ttcttattgg gtaaaaggtg ttttatctga ctatcaggca actattacca aatatgccgg
     9841 aaatgacgca ggtttctatt cacaaagtga tggtgatggt aaatattatg taggacaaaa
     9901 gattggtgag atttggggat atcactcaaa cggccttttc caatcagacg atgaagctgc
     9961 aacaatagac caaagcgaac tttatgctgg aaaatggggt gcgggtgatg taaaatacga
    10021 agacttagat aataatggta aaatcacaaa aggggaagaa acaatctata acccgggtga
    10081 taagagcatc ataggtaata aaacacctcg ttatcaattt ggtattaccg ttggatttga
    10141 ttataagaac ttcgatttcg agatgttttg gcaaggaaca ggaaaacgtg actatatgtt
    10201 gagtggcgct cagttctggg gattcaccag ccaatgggat gttccatata ctccggccct
    10261 tgattattgg acagaaacaa atacagatgc ttattttcca agaccaggat ggcaaaatgg
    10321 cggtaacaga gtcacaagtg accgttattt acaaagtgca gcttacgggc gtttgaagaa
    10381 tttgacggta ggttacacaa ttccgaagaa tctaacgaca aagtggggca tttctcgttt
    10441 gagattatat gtgacaggag aaaacctact cactatcact cctctgaacg atgccttcga
    10501 tcccgaaaca ttgggaggaa tgacataccc gattaatcga aaagttgcaa ttggattaaa
    10561 tttaacactg taaaaaacga aagatgacaa tgaaaactaa acatatctta ttaggattaa
    10621 gtcttggatt gttaggagga tttacggctt gtgacgtgac agacctcaat ccaaaagaca
    10681 gcattaccga caatagctac tggaatacag ttagcgattt ggaaaattat gccaaaggct
    10741 tttacatgaa cctgacagga aaaggtttaa gggcagatgg aagtgaaaat ttggatgatt
    10801 taaatactct tgatgaaaga agtgacaatc gtctggtcgc ttctcccgac caatggttgt
    10861 tcaacgaatg ggtaatacct tctgaagcaa atttcgattc aaaatggtat tggaacaata
    10921 ttcgtaatct aaactatttt atgactcgtt accaacgggt aaatgcgaca gattctgaag
    10981 taaatccggt tgttgccgta attcgctttt tccgggcttt cgattatttc gataaaatca
    11041 agacatttgg agatgttcct tggtatgaaa aggatttgac aactgccgat attgacgaat
    11101 tgtataaagc acgtgacgac cgtgactttg tactagggaa aattatcgaa gatctggaat
    11161 ttgcaattga atggttaccg gaaaaaagtg cagcagaggt aggtgcttta cataaagatg
    11221 ccgctcgtac atttttagca cgtgtttgcc tacattatgg aacatataaa aagtatcata
    11281 atgtttcgac atcacctaca tctcaggaat tattacaaaa agcggcgact cttgccaaag
    11341 aagtgatgga tagtggtctt tacgatatcg tacaaggctc ggatgccgga gcaaaccagt
    11401 ctgcttttgc cgattatccc ttgtattatg caaaccagtt tacacaagag gatttaacga
    11461 ctaataaaga atgtattcta gcacgtgttt tcgaagcaga cgtattgact cataatctcg
    11521 ctcgtggtgg aggagtcggc ctttctaaag attttgcaga atcattcctt tgcaaggacg
    11581 gtttgcctat tgcaaacagt agtgaataca agggagatga aacactggat gatgaaatgg
    11641 caaaccgcga tcctcgtatg tatcagatta tagacagtaa atatcgtcca tatacggtca
    11701 aaagcaatgg tatgcgtgta gtaaattccg gtattgatga taaaaaggaa tttagtccgt
    11761 ctgaagaacc aggaacaaat gtccattcag ctccgggatt aaccgggact gccacaggat
    11821 actcacctat caaactggtg tcagcaagcc agagccaaca agatgcagtg aaaacatctt
    11881 cttacgactg gtttgttttc cgttacgcag aaatcctgct gatctacgct gaagccaaat
    11941 gcgaattagg tgaatgcaca caggctgttt tggatgagac gattaataaa ttgcgcgacc
    12001 gtgttgagat gaaacattta acagtatctc cagtagccga tctgaatccg gttgattatg
    12061 ggtattctat aactccgttg ttatatgaaa tccgccgtga acgtcgtatc gagttggctt
    12121 tggaaggttt ccgttatgat gatatcatgc gttggaatgc gatgaaacta ttcgaaaatc
    12181 ctaaaacata tctaggcatg cgtgttacag ataaagtaaa agcgttatac caacctgaag
    12241 tatttgaagg atcaacagcc cgtgatttaa tcgaatataa tggtaaaact tatatccgca
    12301 tgtattctgg taaaagtttg aacgaagccg gccgtaaatg gacaggaaac gacaagcgtc
    12361 tgtactatcc tatcccaaca agtcagatta cattgtctgc aagccatggt tctcttctaa
    12421 aacaaaatcc gggttgggaa taaatctcat acaagaggga aggttagcct tccctcttta
    12481 tttccctcaa taaaatataa tgagaatata ttacttatct tattgtctgc tggctaacag
    12541 gacgtttata ttacaaccct atagaatata tagagagtta cacacatcat aaatgttccg
    12601 aaatcaggca tgtatacagt aggtgctcaa aacgggattt tatatgaaca agaaagactt
    12661 aatattaaat attcttttat ttattagtca aataatagtc ttttattatt tcttctgcta
    12721 tttattccct tttaaggaac agctacaaat gtttcaattt acatcacagt acctaactga
    12781 aacactgaag caggctggtg gtgtcgctat ttatatatcg gaatttctct ctcaattcta
    12841 tgtggtattt tggacaggac ctatcatttc tgctctactt ttaactttag tggctttatt
    12901 atcatcatta atactgaaaa agattaactc acgaaacgat ttacctctta ttttcctgtt
    12961 accctggcta tctttactaa ttattagttt agactatgat tattatgaac aaggaactat
    13021 tgcttattta tttttattgc tttttctatg gctatataca aacataaaaa cacgaataaa
    13081 atttatttat ggcatttgca tcattcctat tttatatgga atagcaggtc ctatcgtaca
    13141 tttatttgct atatcggcat tgttctttga gtttttaacc aatggaaaga aaaaatatat
    13201 tagtattatt tatttgttga ttgccgcact ttcagcaatt gcaggtactt acttaggata
    13261 tagtagaaat ttaactttag cgtttttacc agaggcttat tgtaatccac tacaaacagt
    13321 atccgggata tattatgcat ggtatgcatt acctatgaca atgcttctgg ttgcttattt
    13381 gaaacgatac aaagaacccg tttctctaaa agggaaatgt atatgggaag gggcacaatg
    13441 ggcaatcatg tttctattgg tctatcaagg aatctttcat tttgggaaat tggatgcaca
    13501 gcattccatg aagcaggact atttgctccg gacggaacag tgggaccttg ttatcagtga
    13561 atttaaccat gatgtattgt ctaaacgccg aatgtgcggt ttaaacttag ctttggcaca
    13621 taaaggccag ctttcagaga gattgttaga ttatcctcaa cacggtattg aaaccttgat
    13681 gctacattgg gatcagtcga tctatacagc acaactgcat agtgatctgt attattgtat
    13741 gggaataata agcgcagcac aaaaattcgc ttttgaagcg tttgtcagtt ctcgttcttc
    13801 cggtaatccg cggatgttga aaaggctgat agagacaaat ctgataacag ggtcctatcc
    13861 gattgcggat aaatatattc aattgttgga aaagacttgg ttctataagg attgggctac
    13921 tgctcaccgt cgatttcttt acaatgataa agcagtcgag gaagataaaa ttttaggaat
    13981 gaaacgtcgc tgttggaagg ccgaagcctc tgctgcaaaa ctatatacag atcctgtcag
    14041 ttcattaata aacttgctcc cggcttgtcc ggataataaa gcaggattag catatttgac
    14101 ttcgttttta ctgttgaaca aagatattga aacttataaa accttgcagg agagcttgta
    14161 ccgttctccc gcctggcgcg atatgacgga atgccagcag gaggcaatcg tgatttgcag
    14221 tcccaatgat ccgcacttct ggttagagca tggggtgagc atcaaagtaa ggaacagagc
    14281 gatcgctttt atgcagaaag tacaagatgt ttcccgttcg gggcagaatc ttgcggtcgc
    14341 tttggcttcc gagtatggca aaacgtattg gtactattat atgtttaata tgatggacaa
    14401 atgaaacaat tgcttttttg catattcctt ttgttgttgg aaggatgttc ttccaaccag
    14461 ccacctgccg tctccgggca gatagatgaa ctgccgacca tctatccgga ttatattgac
    14521 gtaaccatac cacaatcgat cgcacctttg aattttgccg tgcaaacgga agggaaagca
    14581 tgcgcggtat ttacaaccga aggatatgca tttaccgttt acgcctccaa cggagccttt
    14641 tccattccca atacagactg ggaaaagtta ttgactgcgg caaaaggaaa acaggtagag
    14701 gtatctgtcc tgacagaaga aaaagggaaa tggaatgcct ttcttccgtt tcatatccgg
    14761 gtttccgaag acccgatcga tccgtatatc gcttaccgcc tgatcgatcc cggttaccag
    14821 ctatggaacg agatgggaat ctatcaacgc gaattatcct ctttcgatca ggaaccgatt
    14881 ctggaaaacc gcctgacgga taataattgc atgaactgcc attcgttttg catgcaggac
    14941 ccggacaaaa tgctgttcca tgtccgtgca aagtatggct gtaccgtgtt tgtggatggc
    15001 gaccggatag aaacgctcga ta
//
