LOCUS       c00065_gnlPro..        15030 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KADDHKHL_65.
ACCESSION   c00065_gnlPro..
VERSION     c00065_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 18:57:26
            Original ID  :: gnl|Prokka|KADDHKHL_65
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15030
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15030
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1590:5030]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1591..5030
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..15030
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15030
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             complement(378..1331)
                     /locus_tag="ctg65_1"
                     /transl_table=11
                     /translation="MKTAIFSIGVFLISLFLGSCQPSETSCSVVDTGKTLDYKIGDKLL
                     FSYNYTTVYPAPGVDSVYKRSGFIHPLKTLGGEVMTNCSPADHYHHFGLWYAWTKTTFE
                     GNEIDFWNLHKKQGTVRFRNFEHVSDNGFVATLDHVVYPDSPAEKVAMNERLEINIGTT
                     SLPGYYIDYHTTIRLASPSPITMEAYRYGGICIRTREDWNDQTAEMLTSEGLSRDEADG
                     SRARWCYYQGKAGNEKACILIVASPSNLNYPEPLRVWDKTVNKPAGDVMWNFSPTKQKA
                     FTLEPGKELSLSYRIYVLDKNINATTAEVLSDFERD"
     CDS             1591..2265
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg65_2"
                     /sec_met_domain="SucD_FumR (E-value: 1.4e-66, bitscore:
                     217.4, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWLLNSSIGKKLIMSISGLFLILFLVFHLCMNIAAVFSGEAYNVI
                     CGLLGSNWYALLGTLVLAAGVVVHFVYAIILTLQNRKARGNDRYAINARPKGVEWASQN
                     MFVLGVIVILFMVLHFTQFWYNMMFAELAGIHGDIHPQDGAAFINFYFQGNVVNTVLYL
                     IWFVALWFHLTHGFWSAIHTIGWNNTVWLSRWECISKWVATIICGLFAVITVIFYLNGV
                     GA"
     CDS             2304..4247
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 194.4; E-value:
                     1.1e-59)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg65_3"
                     /sec_met_domain="FAD_binding_2 (E-value: 3.4e-59, bitscore:
                     194.4, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 2.2e-37,
                     bitscore: 121.5, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQIDSKIPQGPLAEKWTNYKNHQKLVNPANKRRLDIIVVGTGLA
                     GASAAASLAEMGFNVLNFCIQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTIKG
                     GDYRAREANVYRLAEVSNSIIDQCVAQGVPFAREYGGLLDNRSFGGAQVSRTFYARGQT
                     GQQLLLGAYSALSRQIGLGKVKMYTRHEMLDVVKVDGRARGIIARNLITGKIERFAAHA
                     VVVATGGYVNTFFLSTNAMASNGSAAWQCYKKGAYFANPCMVQIHPTCVPVKGDFQSKL
                     TLMSESLRNDGRIWVPKKLEDAKALQAGTKKGKDIPEADRDYYLERRYPAFGNLVPRDV
                     ASRAAKERCDAGFGVNSTGLAVFLDFSDAINRLGKEVVKQKYGNLFDMYEEITNDDPYE
                     TPMMIYPALHYSMGGLWVDYELMTSIPGLFAIGEANFSDHGANRLGASALMQGLADGYF
                     VLPYTIQNYLSDQIQVPRFSTDLPEFVEAEKAINARIAKLMNVKGKETVDSIHRKLGHI
                     MWEHVGMARDAEGLKEAIQMLKDLKKEFWSNVFIPGEANSLNVELDKALRLADFIEIGA
                     LMAHDALDRAESCGGHFRTEHQTEEGEAMRHDDKFMYVSCWEYQGEDKDPVMLKEDLNY
                     QFVVPQTRNYKK"
     CDS             4275..5030
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg65_4"
                     /sec_met_domain="Fer2_3 (E-value: 1.4e-25, bitscore: 83.0,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_8 (E-value: 4.1e-11, bitscore: 36.8,
                     seeds: 153, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 4.3e-05, bitscore: 17.5,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKDIKVTLKVWRQKGPKDKGQFETYQIDKINQSVSFLEMLDILN
                     ERLVSEGKEPIVFDHDCREGICGMCSLYVNGHPHGPATGATTCQLYMRRFNDGETITIE
                     PWRSAGFPVIRDLMVDRYAYDKIIQAGGFVSVNTGGVPDANAIPISKADADLAMDAAAC
                     IGCGACAAACKNGSAMLFVSAKVSQLALLPQGKVEAARRAKAMVAKMDELGFGNCTNTR
                     ACEMECPKNISVSNIARLNREFISAKLQD"
     CDS             5225..5383
                     /locus_tag="ctg65_5"
                     /transl_table=11
                     /translation="MKKTHCKYKVYLLNTQEFVITFYCKFATFCFKIDTVCGFTLLLYQ
                     QSIDSDT"
     CDS             complement(5356..6387)
                     /locus_tag="ctg65_6"
                     /transl_table=11
                     /translation="MKIGTIDLGERPIFLAPMEDVTDISFRLMCKRFGADMVYTEFVSA
                     DALIRSVNKTQQKLNVADEERPVAIQIYGRDVPTMVEAAQICEAAHPDILDINFGCPVK
                     RVAGKGAGAGMLRNIPLMLDISREVVKAVNIPVTVKTRLGWDADNRIIVDLAEQLQDCG
                     IAALSIHGRTRAQMYTGEADWTLIGEVKNNPRIQIPIIGNGDVTSAEICKQRFEQYGVD
                     AVMIGRGSIGRPWIFREVRHYLDTGETLPAESFSWYLDILKKQVEQSVERLDERRGILH
                     IRRHLAATPLFKGIADFKQTRVAMLRAETVEALFDILDSIPDKFHTGYGFQSDSQVSES
                     IDC"
     CDS             6768..8027
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_U32"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg65_7"
                     /sec_met_domain="Peptidase_U32 (E-value: 1.9e-68, bitscore:
                     223.6, seeds: 96, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LNEKDFEIMAPVGSYESLMAAIQGGADSIYFGIEGLNMRSRSSNN
                     FTTDDLRKIVALCREHGIKSYLTVNTVIYGEDLPLMREIIDAAKEAEVSAIIAADVAAM
                     NYANSIGQEVHLSTQLNISNAEALKFYARFADVVVLARELNLKQVHEIYRQIVDQQITG
                     PKGELIRIEMFAHGALCMAVSGKCYLSLHEMNASANRGACMQICRRAYSVKDKDSNIEL
                     DIENQYIMSPKDLKTIHFMNKMMDAGVRVFKIEGRARGPEYVRLVTECYKEAVRAYCNG
                     TFDEKKVAAWDERLRSVFNRGFWDGYYLGQRLGEWSSKYGSGATKKKVYVAKGIKYFDK
                     IGVAEFEMESGNLKVGDEILITGPTTGAVMQTIEEIRVDLKPVDETVKGERFSLKVNEK
                     IRPSDRLYKMEKVQLEKVFE"
     CDS             8027..8434
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HBT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HBT_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg65_8"
                     /sec_met_domain="HBT (E-value: 2.7e-08, bitscore: 27.7,
                     seeds: 132, tool: rule-based-clusters)"
                     /sec_met_domain="HBT_2 (E-value: 4.2e-09, bitscore: 30.5,
                     seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYIFKLTDKVRDYECDLQGVVNNSNYQHYMEHTRHEFLESLGE
                     NFGKMHEKGVDGFVSRVEIQYKTSLKSGDSYISCLNVYKKGVKLVFEQDIYRASDNALA
                     TKGIVESVIVENGKLTRGEYFDEMLKRIEHT"
     CDS             8431..9546
                     /locus_tag="ctg65_9"
                     /transl_table=11
                     /translation="MTDKRIYQIGLTMINGVGDILARHLLQALGEAEAVFTEKQQLLGR
                     IPGIGSNIAAEIKRPEILQRAEKELAFIEKNNISCYYLTDTDYPVRLRECPDAPILFYF
                     KGNTNLDATRIISIVGTRNATEYGRELTESLIKDLAKVIPDLLVVSGLAYGIDICAHRN
                     ALYNRLPTVAVLAHGLDRIYPSCHRNTAVEMLESGGLLTDFPSGTEPDRPNFLRRNRIV
                     AGISDCTIVVESAEKGGSLVTADIAFSYGRDVYSFPGRIGDSHSKGCNNLIRQNKAGLI
                     TSADDLLSALCWDIQAGATSVQTELFFAEAETFTSEQNPVLAIMRTRNEIHINELASVL
                     EIPVHQLSMLLFELEINGKVKALPGNLYKLS"
     CDS             complement(9797..10687)
                     /locus_tag="ctg65_10"
                     /transl_table=11
                     /translation="MLSFILVLLLGGFMPAGNLLASDKEQNPHYITVKNSRDLQAYFRY
                     APDRPIVISGHRGGMLDGYPENCIESFEKTLSYMESFFEIDPRLTKDGIIVLIHDETID
                     RTTTGKGKVSDYTYAELQQFNLVDRNGNVTAFKIPTLKECLEWSKGKTILNLDIKDVPL
                     EVMADFIETEKPVNVMYTVHNASQARYYLDRKPDAMFSCWCKNREEFDNYEKAGIPWKQ
                     VMAYVGPKMKPEQQPLYDALHRNGVMCMISVAPTHDRAKTETEKTAGYRSEISTRPDVI
                     ETDYPYLFQGLDLTK"
     CDS             11295..11657
                     /locus_tag="ctg65_11"
                     /transl_table=11
                     /translation="MERLTRQEEDVMRWIWQIEPCFIKDILAKYEEPKPPYTTLASIVK
                     NLERKKYVKAKRYGNTYEYRPLIPQEEYKRTFMGSVVNNYFENSYKEMVSFFAKEQKIS
                     TDELKEIIDMIEKGRE"
     CDS             11678..13414
                     /locus_tag="ctg65_12"
                     /transl_table=11
                     /translation="MTPEFAYFLKVNVAFILLYAFYRLFFYKDTFFKLRRTILLAFFGV
                     SLLYPLMNIQDWIREQGPIVEVIQMYSAILPETTITPGNVPQTNWHDLLLPGISYLYWS
                     GVIALSFRFLVQLSSILLLARRSEVTLIRNVRVHLLNKPAGPFSFFRLVFLHPDSHSEK
                     EIDEILVHECTHVSQWHSIDVIICELVCIICWVNPFVWLLKREVRHNLEYLADDTVLES
                     GYDSRSYQYHLLGLAHTNRSVTSLSNNFNMLHLKNRISMMNKKRSRSIGRTKYLIFIPV
                     VGALLILSNVDALARITDELTESTFADVLLPEAILPFPFVGDASPAEKREEYVLSEEGI
                     EAARRARNQVFTVVEVMPEFPGGQGALLKFLATNVRYPESAVKNGIEGRVSCSFVVGKD
                     GAISEAEVIRGVSPELNEEALRVINSMPVWSPGKQRGKVVNVKYTVPVTFRLSGGKKKT
                     SSRIVQRQIKEVDTSGRVFTVVQQMPEFPSGQASLLKYLATRIKYPAIAQENGIQGRVS
                     CSFVVDTDGSLKNIEVIRGIDPSLDREAVRMIREMPKWNPGVQNNMAVAVKYTVPVTFR
                     LQ"
     CDS             13448..15001
                     /locus_tag="ctg65_13"
                     /transl_table=11
                     /translation="MKCKFSLLLFLCVLSLWGQAQSLNLQELVNKKQFQEVVARADSLT
                     PADSADYATMSAIGQAYEGLLRYKEAYQCFSHCLKMDTNNVDALNAVARNAINFGRIAE
                     AKQCYRKVLGTDSMNFYANYQLARLYYQLGDYGRATEHYHILASIEGENPSILTGLADC
                     HIKRGTGPNTMIALSLYARALELNPENVRVASSLINTLLRMGDGQGALQVCDTALFYNP
                     DNSQIRQSKGMALYMTKDYKQADSVYTGLLADGDSSFLNLKYAGAARYMSGHALDGVEL
                     LEKAYEIDSTDVETVMLYGASLGKTYDRKRAYELFDLAETNMQPKKFLVNMLTTFRGDA
                     LERDGRWPEAEKLYYAAWKEDPTQLHFLYKISTQYWDVDPGLFQQEEKLQKTIFSRYTY
                     LTAYMKTDKSQKYLYNYRPFLEAVCEDAFFRNADEVTMLAPDGKKTKLAVADLRALVAQ
                     LPQMPEDERLRREKMQEHIKKAREKEKELRKSGAKLDTLALSKEEKEKARKMLKDADLE
                     "
ORIGIN
        1 ccttgcgacg agtcaatgac ttctcttttt tcatctttgt tgacttttat gaagtcaacc
       61 tatttcagga cgagacaatc gctcatctat ctgttttaaa tgaataaact ccaagcattt
      121 taaggtaaaa gtagggagac aattttatca acacccccat gtatccgccc ccgacacccg
      181 gatcttacgc tcttatagat ccgggtgtcg ggggcggata catgggggtg ttgggtaagt
      241 tttattacgt gtttttcatt gatttgtagc tgtatttaca taaaagagcc ttgtctttga
      301 tgatatagga gaacaagccc tttttccttt tcttgtttac cttgccctgc aaattgtcag
      361 cttgttttag tagaaattca atcacgttcg aaatcggaca gcacttctgc cgtagtagcg
      421 ttgatgttct tgtccaatac ataaatgcgg taagacaggc tcagttcttt accgggttcc
      481 aatgtgaatg ccttctgctt ggtcggtgag aaattccaca tgacgtcacc ggcaggcttg
      541 ttgactgttt tgtcccatac gcgtaaaggc tcaggatagt tcaggttgga aggggaggca
      601 acgattagga tacaggcctt ttcgtttccg gctttccctt ggtagtagca ccaacgggct
      661 ctcgaaccgt cagcttcgtc gcgggaaagg ccttccgagg tgagcatttc ggctgtctga
      721 tcgttccagt cttcgcgcgt acggatgcat atgccgccat aacggtaagc ttccatggtg
      781 atcgggctag ggctggcgag gcggatagtg gtatgatagt cgatgtaata acctggtaag
      841 gatgttgtcc cgatgttgat ctccaggcgt tcgttcattg ctactttttc tgcgggagaa
      901 tcggggtaga ccacatggtc cagtgtcgca acaaaaccgt tgtcggatac gtgttcgaag
      961 ttgcggaagc gaactgttcc ttgttttttg tggagattcc agaaatcgat ctcgtttcct
     1021 tcgaacgtgg ttttcgtcca ggcataccac aaaccgaaat gatggtaatg gtcggcggga
     1081 gaacaattgg tcatcacttc gcctcccaat gtcttcaaag gatggatgaa accgctgcgt
     1141 ttatagaccg agtcaacgcc aggggctggg taaaccgtgg tatagttgta agagaacaac
     1201 agtttatctc ctatcttata gtctaaggtt ttccccgtgt cgacgacgga acaggatgtt
     1261 tcggaaggct gacaagagcc taagaacaga gaaatcaaaa aaacaccaat agaaaaaata
     1321 gcagttttca taatatgaca attaaataat aatcagttat ccggcaagac cttgcctgta
     1381 tcggctacaa aaaaacgaaa ttttttcatt tcgcacaatc cgtttgtgat atctgatgca
     1441 aataaaacca gccagcaagc agtgttctaa ttgatgaaat atttctttaa tcgtttgcgt
     1501 gatatgggga tttagcatac ctttgcacga taataaccat agattggagg aaatttctaa
     1561 atacaattaa ataacttaaa ttattatctt atgtggttac ttaattcttc tatcgggaag
     1621 aagctgataa tgagtatatc aggtcttttt ctcattctgt tcttggtgtt ccacttatgt
     1681 atgaacattg cggcagtatt ttctggtgaa gcgtataacg tgatttgcgg tttgctgggt
     1741 tctaactggt atgctttgct cggtacattg gtgttggctg caggtgtagt cgtgcacttc
     1801 gtgtatgcta ttatcttgac tctgcagaat cgtaaggctc gcggtaacga ccgttatgcc
     1861 atcaacgctc gtccgaaagg tgttgaatgg gcttctcaga acatgtttgt tttgggtgtg
     1921 atcgttatcc tgttcatggt tctgcacttt actcagttct ggtacaacat gatgtttgcc
     1981 gaactggcag gtattcatgg tgacattcat ccgcaggatg gtgcagcgtt tatcaatttc
     2041 tacttccagg gcaatgttgt gaatacggtg ttgtatctga tctggttcgt tgctctgtgg
     2101 tttcacctga ctcacggttt ctggtctgcg attcacacaa ttggctggaa caataccgtt
     2161 tggttaagcc gttgggaatg tatctctaaa tgggttgcca ctattatttg tggcttattc
     2221 gctgttatca cagttatctt ctacctgaac ggtgtaggtg cttaatttcg gatattattt
     2281 tttcaatttg aaaataaaac attatgactc aaatagattc taaaattcct caaggcccgt
     2341 tggctgagaa gtggacaaat tataaaaatc accagaaatt ggtgaatccc gcaaacaaac
     2401 gtcgtttgga cataattgta gtaggtactg gtctggcggg tgcttctgct gctgcctctc
     2461 tggctgaaat gggattcaat gtattgaatt tctgtattca ggactctccc cgtcgtgcac
     2521 actctatcgc tgcacagggc ggtatcaatg cggcaaagaa ttatcagaat gatggtgact
     2581 cggtttatcg tctgttctac gatacaatca aaggtggtga ctaccgtgcc cgcgaagcaa
     2641 acgtctatcg tctggctgaa gtgtcaaact ctattatcga ccagtgtgtg gcacagggtg
     2701 taccattcgc tcgcgaatat ggtggtctgt tggataaccg ctcattcggt ggtgctcagg
     2761 tatcccgtac gttctatgcc cgtggtcaga ccggacagca gctgctgttg ggtgcttact
     2821 ctgcattgag tcgtcagatt ggtttgggaa aggtgaagat gtacacacgc catgaaatgc
     2881 tggatgttgt gaaggttgac ggacgtgctc gcggtattat tgcccgtaat ttgattaccg
     2941 gtaagatcga acgttttgcc gctcacgcag tcgttgttgc gacaggtggt tatgtaaata
     3001 cattcttctt gtctactaac gcgatggcgt ctaacggttc tgctgcatgg cagtgctaca
     3061 agaaaggggc ttactttgct aatccttgta tggtgcagat ccacccgact tgtgtgccgg
     3121 tgaaaggtga cttccagtct aaactgactt tgatgtcaga atcactgcgt aacgatggtc
     3181 gcatctgggt tccgaagaaa ctggaagatg cgaaggcatt gcaggccgga acaaaaaagg
     3241 gaaaggatat tcctgaagca gatcgcgact actatctgga acgtcgttat ccggcattcg
     3301 gtaacttggt tcctcgtgat gtggcttcac gtgccgctaa agaacgttgt gatgccggtt
     3361 tcggtgtaaa tagcacgggc ttggcggtat tcctggattt ctccgacgct atcaaccgtt
     3421 tgggtaagga agtggttaaa cagaaatatg gtaacctgtt cgatatgtac gaagagatca
     3481 cgaacgatga tccgtacgaa actccgatga tgatttatcc tgcattgcac tactcaatgg
     3541 gtggtttgtg ggtagactat gaattgatga cttctattcc ggggctgttc gcaatcggtg
     3601 aagccaactt ctctgaccac ggcgctaacc gtctgggtgc ttctgctttg atgcagggat
     3661 tggctgatgg ttactttgta ttgccttaca cgatccagaa ctatctgtct gaccagatcc
     3721 aggttccgcg cttcagcact gacctgcctg aatttgtgga agcagaaaag gctattaacg
     3781 cccgtatcgc gaagttgatg aacgtgaagg gtaaagaaac agtcgattct atccaccgta
     3841 agctgggaca tatcatgtgg gaacacgtcg gtatggcacg cgacgcggaa ggcttgaaag
     3901 aagctatcca aatgttgaaa gacctgaaga aggaattctg gagcaatgta ttcattccgg
     3961 gtgaagcgaa cagcttgaac gtggaattgg acaaggcatt gcgtttggct gactttatcg
     4021 aaatcggtgc attgatggca cacgatgcgt tagaccgcgc agaatcttgt ggtggccact
     4081 tccgtacgga acatcagacc gaagaaggcg aagctatgcg tcatgacgat aagttcatgt
     4141 acgtctcttg ttgggaatac cagggtgaag acaaagaccc ggttatgctg aaggaagatt
     4201 tgaactatca gttcgttgtt cctcaaacac gtaactacaa gaagtaataa tcatcaatca
     4261 caaaaattag aatcatggat aaagatataa aggtaacact taaagtttgg cgtcagaaag
     4321 gtccgaaaga taaaggacag tttgagactt accaaatcga caaaatcaat cagagtgttt
     4381 ctttcttgga aatgttagac attttgaatg aacgtttggt tagcgaaggc aaagaaccta
     4441 tcgtattcga ccacgactgc cgtgaaggta tctgcggtat gtgttcattg tatgtaaacg
     4501 gacatccgca cggaccggca acaggtgcaa caacctgtca gctctatatg cgccgtttca
     4561 atgatggtga gacgattacg atcgagccgt ggcgttctgc cggtttcccg gtaatccgcg
     4621 acttgatggt agaccgttat gcttatgata agattatcca ggcaggtggt ttcgtttctg
     4681 taaacacagg tggggttcct gatgctaatg caattcctat ttctaaggct gatgcggatt
     4741 tggctatgga tgctgctgct tgtatcggct gcggtgcttg tgctgctgct tgtaagaacg
     4801 gttcagctat gctgttcgtc tctgcaaagg ttagccagct ggctcttttg cctcagggta
     4861 aggtggaagc tgctcgtcgt gcaaaagcaa tggttgctaa gatggatgaa ctgggctttg
     4921 gtaactgtac gaacactcgt gcttgcgaaa tggaatgtcc gaagaacatc tccgttagca
     4981 acatcgctcg cttgaaccgc gagttcatct ctgctaagtt acaagactaa tacattatat
     5041 atatatatgt atatggaaaa gctcgtcgcc aatggcaacg ggctttcttt atgttcgttc
     5101 aaacccacaa aaaagccgca ctccctataa taaaagtgga tgcggctttt ttgttgcttt
     5161 ccagtgaaac agtctctcga ttccctctct gcaaagactt tgttaacctt agatctaaaa
     5221 tactatgaaa aaaactcact gcaaatataa agtatattta ctgaatacgc aagagtttgt
     5281 aattacattt tattgcaaat ttgctacttt ttgttttaaa attgacactg tgtgcggatt
     5341 cacactgtta ttatatcaac aatcgatcga ttctgacact tgagagtcac tttgaaatcc
     5401 gtatcctgta tgaaatttgt cggggatgga atccagaatg tcgaataatg cttccactgt
     5461 ttccgcacgt agcatggcga cgcgtgtctg cttgaagtct gcaatacctt taaacagcgg
     5521 agttgcagcc aaatggcggc gaatgtggag aattccccgg cgctcatcca aacgttccac
     5581 gctttgttcc acctgctttt tcagtatgtc cagataccat gaaaaagatt cggcaggcaa
     5641 tgtctcgcct gtatccagat aatgcctcac ttctctgaaa atccaggggc ggcctatgct
     5701 gccccggcca atcataacgg catccacgcc atattgttcg aaacgttgtt tgcagatttc
     5761 ggcggaagtc acatcgccat tgccgatgat gggaatttgt atgcggggat tgttttttac
     5821 ttcaccgatc agtgtccagt ctgcctctcc tgtgtacatc tgtgcccggg tacgtccgtg
     5881 gatggaaagg gctgcgatac cgcaatcctg tagctgttcg gccaagtcta cgatgatccg
     5941 gttgtcggca tcccagccca agcgggtttt tacggtgaca gggatgttca ccgctttgac
     6001 gacttcacgg ctgatgtcca gcatcagtgg aatattgcgc agcatgccgg cgcctgctcc
     6061 tttgcctgcc actcgtttga cagggcaacc gaaattgata tcgagaatgt ccggatgagc
     6121 ggcttcgcaa atttgcgcgg cttcgaccat tgtcggaaca tcacggccat atatttgtat
     6181 ggcgaccgga cgttcttcat ccgccacatt cagcttttgc tgtgttttat ttacactgcg
     6241 gatcagggcg tctgctgaaa cgaattcggt ataaaccata tcggcaccaa aacgtttgca
     6301 catcaaccgg aaagaaatat ctgtaacgtc ttccatcgga gctaagaaga tggggcgttc
     6361 gcctaaatct attgtaccta ttttcatatt tatattatca atgacgggga caaaggtact
     6421 gatttcctgc taaaaacagg gataaaagga tatctactaa aaaatgtagt aattgatcaa
     6481 taaaaagtac aaatgtcata ctgtcaatga tataggtaaa atgataagct gaaatcatga
     6541 tagttacatg atagtagtat gatagttaaa aatagaaact atcatgtctt aaggtattga
     6601 ataacaggtt ctaaaggaca acaatgacag tatgatggtt gttttgcaaa tctttataga
     6661 aaatggtatt tgatcacgat tttgatgctc tgagaaacgg atacccatgc aattcttctc
     6721 ggatattatt cctacctttg cgaacgaacc agtaaatgta taagaacttg aacgagaaag
     6781 attttgaaat aatggcgcct gtcggttcgt acgaatcact gatggcggct atccaagggg
     6841 gagccgattc tatctatttc ggtatcgaag gattgaatat gcgttcgcgc tcttccaata
     6901 actttacgac agacgatttg cgcaagatcg ttgcgctttg tcgtgagcac ggtattaaga
     6961 gctatttgac cgtcaatacg gttatttatg gggaagacct gcctctgatg cgcgagatta
     7021 tcgatgcggc gaaggaggcg gaagtttcag cgatcattgc ggccgatgtg gcagctatga
     7081 actatgccaa cagcatcgga caggaggtgc atctttccac acagctcaac atttccaatg
     7141 cggaagcact gaaattctat gcccgttttg ccgatgttgt cgtcttggcg cgtgagctga
     7201 atttgaaaca ggtgcatgaa atctatcggc agatcgtcga ccagcagatt acgggaccga
     7261 aaggagaact gatccgtatc gaaatgtttg cccacggagc tctctgtatg gccgtttccg
     7321 gtaaatgtta cctgagcctg cacgaaatga acgcttccgc caaccgggga gcttgcatgc
     7381 agatttgtcg gcgtgcttat tcggtaaaag ataaagacag caatatcgaa ctggatatcg
     7441 aaaaccagta tattatgtcg cctaaagacc ttaagacaat tcatttcatg aataagatga
     7501 tggatgcagg tgtacgggta ttcaagatcg aaggacgtgc ccgcggtccc gaatatgtcc
     7561 gcctggtgac cgaatgctat aaggaagctg tgcgtgctta ttgcaatggc acgttcgatg
     7621 aaaagaaagt tgccgcttgg gacgaacgcc tgcgcagtgt gttcaaccga ggattctggg
     7681 acggctatta tttggggcaa cggttgggtg agtggagtag caaatatggc tccggcgcga
     7741 ctaagaagaa agtgtatgtt gccaaaggaa tcaaatattt cgacaagatc ggcgtggcgg
     7801 agttcgaaat ggaatccggt aacctgaaag tgggtgatga gatcctgatt accggaccga
     7861 caacgggtgc ggttatgcag acgatagaag aaatccgtgt ggacttgaag ccggtggacg
     7921 agaccgttaa aggtgaacgg ttctctctca aggtgaacga gaagattcgg ccgtctgacc
     7981 gattgtataa aatggaaaag gttcaacttg aaaaggtatt tgaataatga aagagtatat
     8041 ttttaaactg acagacaagg tccgtgacta cgaatgcgac ctgcaaggag tggtcaacaa
     8101 ctccaattat cagcattata tggaacatac tcggcatgaa ttcttggagt cgcttggcga
     8161 gaacttcgga aagatgcacg aaaaaggggt tgacggattt gtatcgcggg tagaaatcca
     8221 gtataagacc tcgctcaaga gcggcgacag ctatatctct tgcctcaatg tctataaaaa
     8281 aggagtcaag ctcgtattcg agcaggatat atatagggct tctgacaatg cattggcgac
     8341 gaaaggaatc gtcgagtcgg ttatcgttga gaacggaaag ttgacacgcg gtgaatattt
     8401 cgacgaaatg ctaaaaagaa tagaacatac atgactgaca aacggattta ccaaatcggc
     8461 cttactatga taaacggcgt gggagatatc ctggcgcgtc atctcctgca ggctttggga
     8521 gaagcagagg ctgtgtttac tgaaaaacaa cagttgttag gaaggatccc tggtatcggc
     8581 agcaatattg ctgccgaaat caaacgcccg gaaatcttgc aacgggcgga aaaagagttg
     8641 gcttttatcg agaaaaacaa tatttcctgt tattatctga ctgatacaga ttatccggtg
     8701 cgcttgagag aatgtccgga tgcccctata cttttctatt ttaagggaaa tactaacctt
     8761 gatgcgaccc gtatcatcag tattgtgggt actcgcaacg cgaccgaata tggtcgggag
     8821 cttaccgaat cccttataaa agacttggca aaagtgatcc cggacttgtt ggtcgtgagt
     8881 ggattggctt acggcatcga tatctgtgcc caccggaacg ctttgtacaa ccgacttccg
     8941 actgttgctg tgctggcgca tggcttggat cgtatctatc cttcctgcca tcggaatacg
     9001 gctgtcgaaa tgctggaatc gggcggtctg ttgaccgatt ttcccagcgg tacagaacca
     9061 gaccgtccaa atttcctccg gaggaaccgg attgtcgccg gaatctcgga ttgtacgatc
     9121 gtggttgaat cggcagaaaa aggaggctct ttggtaactg ccgatattgc attctcttat
     9181 ggccgggatg tctatagctt tccagggcgc atcggtgaca gccattccaa aggatgcaac
     9241 aatttgatcc gacaaaataa agccggcctg atcacttctg cggacgatct gctctccgct
     9301 ctttgttggg atatccaagc tggggctact tccgttcaaa cggagttgtt tttcgccgag
     9361 gcggaaacat tcacctcgga acaaaatccg gttttagcca ttatgcgaac gcggaatgag
     9421 atccatatca acgagcttgc ctcagtgttg gagataccgg tacatcaact ctctatgcta
     9481 ttgttcgaac tggaaataaa cgggaaggta aaagcgttgc cgggaaatct ctataagctg
     9541 tcctgaccgg ctttttcgta tacgatttgt atgtgggaga agaaacggaa cctctataaa
     9601 caattaaagg ctgtctcacg acaaccccta accaactttg ttaaccttaa atctaatact
     9661 attatgaaaa aaccacattg caaagataca ctcgtcaaga gcgtttgtca agcattttgt
     9721 cgctaatact tgttaatcag atgagcataa atagcaaaaa gattttaatc ggctataaag
     9781 agtcctttaa actgcgttat tttgttaaat cgagtccttg aaacaggtac ggatagtccg
     9841 tttcgatcac gtcgggacga gtgctgatct ctgaccggta accggcggtt ttctctgttt
     9901 ccgttttcgc gcgatcatgt gtcggagcaa cggaaatcat gcacatgact ccgttacggt
     9961 gcagagcgtc atacagtggt tgctgttcag gcttcatctt cgggcctaca taagccatta
    10021 cctgtttcca ggggatgccg gctttttcat aattatcgaa ttcttcccga ttcttacacc
    10081 agcaagaaaa catcgcatcc ggtttccggt cgagataata gcgggcttga ctggcgttat
    10141 gtaccgtgta catgacgtta acaggctttt ctgtttctat aaaatcagcc ataacttcta
    10201 aaggtacatc cttgatatcc aaattcagga ttgttttgcc tttgctccat tccaggcatt
    10261 cttttaaagt tggaattttg aaggctgtca cgttgccgtt tcggtccacc agattgaatt
    10321 gttgcagttc tgcataagtg taatctgaaa cctttccttt cccggtagtt gtccggtcga
    10381 tggtttcgtc gtgtatcaat acgattatcc cgtcttttgt caaacgcgga tctatctcga
    10441 aaaacgattc catataggac aaggtctttt cgaatgattc gatgcagttc tccggatagc
    10501 cgtctagcat tccaccacga tgtccactga ttacaatcgg gcgatcggga gcataccgga
    10561 aataggcttg tagatcccgg ctgttcttca cagtaatgta atgaggattt tgttctttgt
    10621 ctgaagccaa aagattcccg gcaggcataa aaccccctaa aaggagtacc aaaataaaag
    10681 atagcatttt catgatattg tatttatata gattctttgt caattatgcg gcttaaaagt
    10741 aagacttttt tatcagtggc gtactataaa agcactataa aaacatgaaa atatgacagg
    10801 caacaagatg tgcaaagaaa gaggcaggta tataaaaaat taaggattgt catctcgaca
    10861 acccctaacc aactttgtta accttaaatc taatactatt atgaaaaaac cacaatgcaa
    10921 aaatacacta gctaagcttg tttgtcaaac cttttacgga taatatatgt taagctctaa
    10981 tagctatttt gtcaaaaaat gttggttatt tataaactat acagattcca tgtaaaaact
    11041 gctaattcaa atacttttta tcgtcggaaa aagtgaaatc ccatgcttaa aaagtgtccc
    11101 cttggagtat ataaaatcat taattaatat aggggatgct ttggtgtggc tgcttataga
    11161 taaattcctt tttggcgcat gcagcgaata gatgatagat tattaattgt taatacaaat
    11221 taacgcatta tttcttgcat atttacgatg tattcgtaga tttgcgatac gatcgtaaaa
    11281 aataatatag aaacatggaa agattaacaa gacaggaaga ggatgtaatg cgctggatct
    11341 ggcagatcga gccgtgtttt atcaaagaca tcctggcgaa gtatgaagag cctaagcctc
    11401 cttatacgac actcgcttct attgtgaaga atctggaacg taagaaatac gtgaaagcga
    11461 aacgttacgg aaatacttac gaatacaggc cgctgatccc acaggaggaa tataaacgga
    11521 cgtttatggg aagtgtggtg aacaactatt tcgagaactc ttacaaggaa atggtctcct
    11581 tttttgctaa agaacagaag atatcgaccg atgagttgaa agagattatc gatatgattg
    11641 aaaaaggacg agaataaact gttaaataca taatgccatg acaccggaat ttgcctactt
    11701 cttgaaggta aatgtagctt ttatactcct ttatgccttc taccggctgt tcttttataa
    11761 ggacaccttc tttaaactac gccgtaccat cttgttggca tttttcgggg tgtcattgct
    11821 ttatccgctg atgaatattc aggattggat ccgggagcag gggccgatag tggaagtcat
    11881 acaaatgtat tcagccattt tgcccgaaac gacaataacc cccggcaatg ttccccaaac
    11941 aaattggcat gatttgttac ttcccggtat ttcttatctt tattggagcg gtgtaattgc
    12001 cttatcgttc cgttttttag tgcagttgag cagcatcttg ttactggcac ggcggtcgga
    12061 agtgactttg atccgtaacg tacgtgtaca tctgttgaat aaaccggccg gtcctttttc
    12121 ttttttccgg ctggtatttc tgcatcccga cagccattcc gagaaagaga tcgatgagat
    12181 tttggtacac gagtgtacgc atgtcagcca gtggcattcg attgacgtga ttatttgcga
    12241 attggtttgt atcatctgtt gggtgaatcc gtttgtctgg ctgttgaaaa gagaggtacg
    12301 tcataatctg gaatatttgg cggatgatac ggtacttgaa tcgggctatg acagtcgtag
    12361 ctaccaatat caccttttgg ggttggcaca taccaataga tcggtgacct ctttatctaa
    12421 taactttaat atgctgcatc tgaaaaatcg gatcagcatg atgaataaga aacgttcccg
    12481 gagcataggt aggacgaaat acttgatttt tataccggtt gtgggcgcct tgctgatttt
    12541 aagcaatgtc gatgcattgg cccggatcac ggacgaactg acggaaagca cgtttgccga
    12601 tgtcttgcta ccggaggcta tcttgccgtt cccttttgtc ggtgatgctt ctcctgctga
    12661 aaaacgtgag gagtatgtgc tatcggagga aggaattgag gctgccagac gtgcccgtaa
    12721 ccaggtgttt accgttgtgg aggtaatgcc ggaattccct ggcggacagg gtgctctgct
    12781 gaaattcctg gcgacgaatg tcagataccc ggaatcggcc gttaaaaatg gtatagaggg
    12841 acgggttagc tgttctttcg ttgttggaaa agacggggct atctcggagg cagaagtgat
    12901 tcgtggggta agtccggaac tgaatgagga ggctttgcgt gtgataaact ccatgccggt
    12961 atggtcgccg gggaaacagc ggggcaaagt ggttaatgtc aaatatacgg taccggtaac
    13021 tttccggctt tccggtggaa agaaaaaaac atcctctcgt atcgtgcaga ggcagattaa
    13081 agaagtcgat acgtccggtc gtgtctttac ggtagtgcaa cagatgccgg aatttccgag
    13141 tggacaggct tcgttgttga aatatctggc aacacgcata aaatatccgg ctattgctca
    13201 ggagaatgga atacaaggac gtgtctcttg ctctttcgtt gtcgacacgg atggaagttt
    13261 gaaaaatatt gaagtgatcc gtggaatcga tccttcgctg gacagggagg ctgtccggat
    13321 gatccgggaa atgccgaaat ggaatcctgg cgtacaaaac aatatggctg tagccgtaaa
    13381 atatacggtt ccggttactt tccgtttgca gtaattgacc agaatcggtc attaatacga
    13441 taccattatg aaatgtaagt tttctctatt actgtttctt tgcgtactgt ccctttgggg
    13501 acaggcgcag agtcttaatc ttcaggaatt ggtcaataaa aaacaatttc aggaagttgt
    13561 agcacgtgcg gatagtctta ctcctgccga ttcagccgat tatgctacaa tgtcggcaat
    13621 cgggcaggcg tatgagggac tgttgcgcta taaggaggcc tatcagtgtt tttctcattg
    13681 cttgaagatg gatacgaaca atgtggatgc attgaacgcc gttgccagga atgcgatcaa
    13741 tttcggaagg atagcggaag ctaaacaatg ttatcgtaaa gtattgggaa ccgacagcat
    13801 gaacttctat gccaactatc agttggcgcg tctctattat cagttgggag attatggtcg
    13861 agcgacggaa cactatcata tacttgcttc catcgaaggt gaaaatcctt ctatcctgac
    13921 cgggctggct gattgccata ttaaaagagg gaccggtcct aatacgatga tcgctctttc
    13981 tttgtatgcc cgtgctttgg agctgaaccc ggaaaatgta cgtgtggcat cttctctgat
    14041 aaatacgtta ttgcggatgg gggacggaca gggagctttg caggtgtgcg ataccgcctt
    14101 gttctataat ccggataaca gccagatacg gcagagtaaa gggatggctc tctatatgac
    14161 gaaagattat aagcaggctg attcagtcta taccggtcta ttggccgatg gcgattcttc
    14221 ttttttgaat cttaaatatg cgggggcggc ccgctatatg tccggtcatg cacttgatgg
    14281 ggtcgagctg ctggagaagg cctatgaaat agattcgacg gatgtggaaa cagtcatgtt
    14341 gtatggcgct tccctgggaa aaacatacga ccgtaaacgg gcttatgagc ttttcgatct
    14401 ggcggaaacg aatatgcagc cgaaaaaatt cctagttaat atgttgacga ccttccgagg
    14461 tgatgccttg gaaagggacg gccgttggcc cgaagcggaa aagctgtatt atgccgcatg
    14521 gaaggaagac ccaacccagt tgcacttcct gtataagatc agtacacaat actgggatgt
    14581 cgatccggga ctctttcagc aggaggaaaa attgcaaaag acgattttca gtagatacac
    14641 ttacctgaca gcctatatga agacagacaa gtcgcaaaag tatctttata attaccgccc
    14701 tttcttggaa gcggtttgtg aagatgcctt tttccggaat gccgatgaag tgacgatgtt
    14761 ggctcccgat gggaagaaga cgaagttggc tgtcgctgat ctgcgtgcct tggtcgccca
    14821 actgccgcag atgccggaag atgaacgttt gaggcgcgag aagatgcagg aacatattaa
    14881 aaaagccagg gaaaaagaaa aggaattgcg taaaagcggt gctaaactcg atacgctcgc
    14941 cctgagtaag gaagaaaaag agaaagcacg gaaaatgttg aaagacgccg acttggaata
    15001 gatagaatat ctgaacaata taatcgatat
//
