LOCUS       c00116_gnlPro..        14035 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OJPEJPGD_116.
ACCESSION   c00116_gnlPro..
VERSION     c00116_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 17:05:43
            Original ID  :: gnl|Prokka|OJPEJPGD_116
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14035
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14035
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1378:4818]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1379..4818
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..14035
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14035
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             complement(166..1119)
                     /locus_tag="ctg116_1"
                     /transl_table=11
                     /translation="MKTAIFSIGVFLISLFLGSCQPSETSCSVVDTGKTLDYKIGDKLL
                     FSYNYTTVYPAPGVDSVYKRSGFIHPLKTLGGEVMTNCSPADHYHHFGLWYAWTKTTFE
                     GNEIDFWNLHKKQGTVRFRNFEHVSDNGFVATLDHVVYPDSPAEKVAMNERLEINIGTT
                     SLPGYYIDYHTTIRLASPSPITMEAYRYGGICIRTREDWNDQTAEMLTSEGLSRDEADG
                     SRARWCYYQGKAGNEKACILIVASPSNLNYPEPLRVWDKTVNKPAGDVMWNFSPTKQKA
                     FTLEPGKELSLSYRIYVLDKNINATTAEVLSDFERD"
     CDS             1379..2053
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg116_2"
                     /sec_met_domain="SucD_FumR (E-value: 1.1e-67, bitscore:
                     217.4, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWLLNSSIGKKLIMSISGLFLILFLVFHLCMNIAAVFSGEAYNVI
                     CGLLGSNWYALLGTLVLAAGVVVHFVYAIILTLQNRKARGNDRYAINARPKGVEWASQN
                     MFVLGVIVILFMVLHFTQFWYNMMFAELAGIHGDIHPQDGAAFINFYFQGNVVNTVLYL
                     IWFVALWFHLTHGFWSAIHTIGWNNTVWLSRWECISKWVATIICGLFAVITVIFYLNGV
                     GA"
     CDS             2092..4035
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 194.4; E-value:
                     1.1e-59)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg116_3"
                     /sec_met_domain="FAD_binding_2 (E-value: 2.8e-60, bitscore:
                     194.4, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 1.8e-38,
                     bitscore: 121.5, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQIDSKIPQGPLAEKWTNYKNHQKLVNPANKRRLDIIVVGTGLA
                     GASAAASLAEMGFNVLNFCIQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTIKG
                     GDYRAREANVYRLAEVSNSIIDQCVAQGVPFAREYGGLLDNRSFGGAQVSRTFYARGQT
                     GQQLLLGAYSALSRQIGLGKVKMYTRHEMLDVVKVDGRARGIIARNLITGKIERFAAHA
                     VVVATGGYVNTFFLSTNAMASNGSAAWQCYKKGAYFANPCMVQIHPTCVPVKGDFQSKL
                     TLMSESLRNDGRIWVPKKLEDAKALQAGTKKGKDIPEADRDYYLERRYPAFGNLVPRDV
                     ASRAAKERCDAGFGVNSTGLAVFLDFSDAINRLGKEVVKQKYGNLFDMYEEITNDDPYE
                     TPMMIYPALHYSMGGLWVDYELMTSIPGLFAIGEANFSDHGANRLGASALMQGLADGYF
                     VLPYTIQNYLSDQIQVPRFSTDLPEFVEAEKAINARIAKLMNVKGKETVDSIHRKLGHI
                     MWEHVGMARDAEGLKEAIQMLKDLKKEFWSNVFIPGEANSLNVELDKALRLADFIEIGA
                     LMAHDALDRAESCGGHFRTEHQTEEGEAMRHDDKFMYVSCWEYQGEDKDPVMLKEDLNY
                     QFVVPQTRNYKK"
     CDS             4063..4818
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg116_4"
                     /sec_met_domain="Fer2_3 (E-value: 1.1e-26, bitscore: 83.0,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_8 (E-value: 3.4e-12, bitscore: 36.8,
                     seeds: 153, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 3.6e-06, bitscore: 17.5,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKDIKVTLKVWRQKGPKDKGQFETYQIDKINQSVSFLEMLDILN
                     ERLVSEGKEPIVFDHDCREGICGMCSLYVNGHPHGPATGATTCQLYMRRFNDGETITIE
                     PWRSAGFPVIRDLMVDRYAYDKIIQAGGFVSVNTGGVPDANAIPISKADADLAMDAAAC
                     IGCGACAAACKNGSAMLFVSAKVSQLALLPQGKVEAARRAKAMVAKMDELGFGNCTNTR
                     ACEMECPKNISVSNIARLNREFISAKLQD"
     CDS             4829..5014
                     /locus_tag="ctg116_5"
                     /transl_table=11
                     /translation="MYVYGKARRQWQRAFFMFVQTHKKAALPIIKVDAAFLLLSSETVS
                     RFPLCKDFVNLRSKIL"
     CDS             5011..5169
                     /locus_tag="ctg116_6"
                     /transl_table=11
                     /translation="MKKTHCKYKVYLLNTQEFVITFYCKFATFCFKIDTVCGFTLLLYQ
                     QSIDSDT"
     CDS             complement(5142..6173)
                     /locus_tag="ctg116_7"
                     /transl_table=11
                     /translation="MKIGTIDLGERPVFLAPMEDVTDISFRLMCKRFGADMVYTEFVSA
                     DALIRSVNKTQQKLNVADEERPVAIQIYGRDVPTMVEAAQICEAAHPDILDINFGCPVK
                     RVAGKGAGAGMLRNIPLMLDITREVVKAVNIPVTVKTRLGWDADNRIIVDLAEQLQDCG
                     IAALSIHGRTRAQMYTGEADWTLIGEVKNNPRIQIPIIGNGDVTSAEICKQRFEQYGVD
                     AVMIGRGSIGRPWIFREVRHYLDTGETLPAESFSWYLDILKKQVEQSVERLDERRGILH
                     IRRHLAATPLFKGIADFKQTRVAMLRAETVEALFDILDSIPDKFHTGYGFQSDSQVSES
                     IDC"
     CDS             6333..6689
                     /locus_tag="ctg116_8"
                     /transl_table=11
                     /translation="MVRLTSKEEEILGYFWAKGPLFVRELLDLQEESKPHYNTLSTIVR
                     SLEEKGYIGYKVYGNTHQYYALVSEDEYRRNSLKQVISKYYDNSYTRVVSTLIEEEVLT
                     IDELQKLIQQIKNK"
     CDS             6703..7335
                     /locus_tag="ctg116_9"
                     /transl_table=11
                     /translation="MDAFLLYILKSGICLTVFYVCFKALFSNDTFFRFNRWILLVGTGV
                     CMLLPLCRIQTARPFPLSRPVSQLEIVFYEEEMKAFPVPESKEEITIPTEQRNISVPWT
                     GIIGIAFLTGSGICLTTTILSFGKMYQLTRKNRKLKQGKYTLILTPDPVSPFSWGRYIF
                     LSENDYRNHPNEILMHEKMHLRYNHSVDLIYMKRFFFCNGLILPYGY"
     CDS             7503..8471
                     /locus_tag="ctg116_10"
                     /transl_table=11
                     /translation="MMLKKKSNNWARLKLALLVPVGFAALSAFARPETSPPPAATMTDN
                     IHLSINKSTVNQETMQQDHAVFLTYKESGSEDLNSIVCKTLDRIRTRVAEGQFKNALEV
                     TVNPAFDDIPASYLETVKDVLEERDIKCKIDMTVPNTIMDDVAKPYRKYDDVVYLIQNK
                     KIVAALSISKFSANQNDPRLDKISKSASLILQPENPKVSRQEMEKLKNLLDKKGLTSEI
                     NMNIFKIGDAAAPPPPPPAGQVIFSYRDGQPDQQFVLYDRHAKPGANLGQRIDKIYKDN
                     ITKVSIKINKSTPKDLLETVKQELKKKINYPVQYEILQFVD"
     CDS             8583..9818
                     /locus_tag="ctg116_11"
                     /transl_table=11
                     /translation="MIHNVKILFFICFFTACSSTEQKEIVTAGELLRQAAFYGERLQFL
                     PALETYQQAIKLAEKEKDSTVFSLAYLEMGKIYRYQSLKQKALQSEKKALSYIKSPACD
                     SLRLELYREIGDMYTLSGQADSAFHYYEMAGCRIKQAKILQQNGSNKEAETLLKTELEQ
                     TIFPKEKAEVCLALADLQITLGKLDEAEKSLSQVPPSHPHLYAALSRIAQSRGDSLQAD
                     FYHKSYLHHLSVLRQEKEQNQITQLLRTSEQKEWEKRLTDSQKAQKEQIYVWVTLLVSC
                     STGIWGYSRYRQKRNVVSLSETDFFSSEIYLRFHRKEEWKPVPKDWEELLQAFNRTYPD
                     FRERLKRKIPKLSEQEWRMCCLIKMEVPPSTAAMLLCCTNQAISMRRVRLYQKITGEKG
                     TPELCDSFIRDF"
     CDS             9885..11081
                     /locus_tag="ctg116_12"
                     /transl_table=11
                     /translation="MKKMLFGLMTAIATFTGCESKQPAGELPRIDLTATSFAFDQVEIA
                     DEIESIEYVPLELTDESLIADVLDLCVSDEYIFVYSTRQDGVLQFDRKGKYLRCIAKTG
                     NGPGETGQIISLTVDEENRLFCVSEYFSTSFYSFDGEFIKKIENPRPYSYQFSVGPNTM
                     AELGRMYVPMNTPGMFSLGVFNWGTDDTIAFRHTIGDMDLMPLEETSLKGWIFSGSKDG
                     ILCYSEGIDTVWDVNARNIAPAFLINTGYSVEEEKEMRSSKTGNEAVDGKYSVFSFFET
                     PRHYFVKCFEGSNQSKFYLYGLDKATGELKRETSPLNAQELFKNNWTLAGIGFRNTKDN
                     GLPIWPYLSYPGKKQMVQFNTAVEIEYLKEKYPDLKKHLVLQQITEDSNPLITIYHLR"
     CDS             11160..12395
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_U32"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg116_13"
                     /sec_met_domain="Peptidase_U32 (E-value: 1.5e-69, bitscore:
                     223.7, seeds: 96, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAPVGSYESLMAAIQGGADSIYFGIEGLNMRSRSSNNFTTDDLRK
                     IVALCREHGIKSYLTVNTVIYGEDLPLMREIIDAAKEAEVSAIIAADVAAMNYANSIGQ
                     EVHLSTQLNISNAEALKFYARFADVVVLARELNLKQVHEIYRQIVDQQITGPKGELIRI
                     EMFAHGALCMAVSGKCYLSLHEMNASANRGACMQICRRAYSVKDKDSNIELDIENQYIM
                     SPKDLKTIHFMNKMMDAGVRVFKIEGRARGPEYVRLVTECYKEAVRAYCNGTFDEKKVA
                     AWDERLRSVFNRGFWDGYYLGQRLGEWSSKYGSGATKKKVYVAKGIKYFDKIGVAEFEM
                     ESGNLKVGDEILITGPTTGAVMQTIEEIRVDLKPVDETVKGERFSLKVNEKIRPSDRLY
                     KMEKVQLEKVFE"
     CDS             12395..12802
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HBT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HBT_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg116_14"
                     /sec_met_domain="HBT (E-value: 9.6e-09, bitscore: 25.6,
                     seeds: 132, tool: rule-based-clusters)"
                     /sec_met_domain="HBT_2 (E-value: 1.4e-09, bitscore: 28.5,
                     seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYIFKLTDKVRDYECDLQGVVNNSNYQHYMEHTRHEFLESLGE
                     NFGKMHEKGVDGFVSRVEIQYKTSLKSGDSYISCLNAYKKGVKLVFEQDIYRASDNALA
                     TKGIVESVIVENGKLTRGEYFDEMLKRIEHT"
     CDS             12799..13914
                     /locus_tag="ctg116_15"
                     /transl_table=11
                     /translation="MTDKRIYQIGLTMINGVGDILARHLLQALGEAEAVFTEKQQLLGR
                     IPGIGSNIAAEIKRPEILQRAEKELAFIEKNNISCYYLTDTDYPVRLRECPDAPILFYF
                     KGNTNLDATRIISIVGTRNATEYGRELTESLIKDLAKVIPDLLVVSGLAYGIDICAHRN
                     ALYNRLPTVAVLAHGLDRIYPSCHRNTAVEMLESGGLLTDFPSGTEPDRPNFLRRNRIV
                     AGISDCTIVVESAEKGGSLVTADIAFSYGRDVYSFPGRVGDSHSKGCNNLIRQNKAGLI
                     TSADDLLSALCWDIQAGATPVQTELFFAEAETFTSEQNPVLAIMRTRNEIHINELASVL
                     EIPVHQLSMLLFELEINGKVKALPGNLYKLS"
ORIGIN
        1 ggcggataca tgggggtgtt gggtaagttt tattacgtgt ttttcattga tttgtagctg
       61 tatttacata aaagagcctt gtctttgatg atataggaga acaagccctt tttccttttc
      121 ttgtttacct tgccctgcaa attgtcagtt tgttttagta gaaattcaat cacgttcgaa
      181 atcggacagc acttctgccg tagtagcgtt gatgttcttg tccaatacat aaatgcggta
      241 agacaggctc agttctttac cgggttccaa tgtgaatgcc ttctgcttgg tcggtgagaa
      301 attccacatg acgtcaccgg caggcttgtt gacagttttg tcccatacgc gtaagggctc
      361 aggatagttt aggttggaag gggaggcaac gattaggata caggcctttt cgtttccggc
      421 tttcccttgg tagtagcacc aacgggctct cgaaccgtca gcttcgtcgc gggaaaggcc
      481 ttccgaggtg agcatttcgg ctgtctgatc gttccagtct tcgcgcgtac ggatgcatat
      541 gccgccataa cggtaagctt ccatggtgat cgggctgggg ctggcgaggc ggatagtggt
      601 atgatagtcg atgtaataac ctggtaagga tgttgtcccg atgttgatct ccaggcgttc
      661 gttcattgct actttttctg cgggagaatc ggggtagacc acatggtcca gtgtcgcaac
      721 aaaaccgttg tcggatacgt gttcgaagtt gcggaagcga actgttcctt gttttttgtg
      781 gagattccag aaatcgatct cgtttccttc gaacgtggtt ttcgtccagg cataccacaa
      841 accgaaatga tggtaatggt cggcgggaga acaattggtc atcacttcgc ctcccaatgt
      901 cttcaaagga tggatgaaac cgctgcgttt atagaccgag tcaacgccag gggctgggta
      961 aaccgtggta tagttgtaag agaacaacag tttatctcct atcttatagt ctaaggtttt
     1021 ccccgtgtcg acgacggaac aggatgtttc ggaaggctga caagagccta agaacagaga
     1081 aatcaaaaaa acaccaatag aaaaaatagc agttttcata atatgacaat taaataataa
     1141 tcagttatcc ggcaagacct tgcctgtatc ggctacaaaa aaacgaaatt ttttcgtttc
     1201 gcacaatccg tttgtgatat ctgatgcaaa taaaaccagc cagcaagcag cgttctaatt
     1261 gatgaaatat ttctttaatc gtttgcgtga tatggggatt tagcatacct ttgcacgata
     1321 ataaccatag attggaggaa atttctaaat acaattaaat aacttaaatt attatcttat
     1381 gtggttactt aattcttcta tcgggaagaa gctgataatg agtatatcag gtctttttct
     1441 cattctgttc ttggtgttcc acttatgtat gaacattgcg gcagtatttt ctggtgaagc
     1501 gtataacgtg atttgcggtt tgctgggttc taactggtat gctttgctcg gtacattggt
     1561 gttggctgca ggtgtagtcg tgcacttcgt gtatgctatt atcttgactc tgcagaatcg
     1621 taaggctcgc ggtaacgacc gttatgccat caacgctcgt ccgaaaggtg ttgaatgggc
     1681 ttctcagaac atgtttgttt tgggtgtgat cgttatcctg ttcatggttc tgcactttac
     1741 tcagttctgg tacaacatga tgtttgccga actggcaggt attcatggtg acattcatcc
     1801 gcaggatggt gcagcgttta tcaatttcta cttccagggc aatgttgtga atacggtgtt
     1861 gtatctgatc tggttcgttg ctctgtggtt tcacctgact cacggtttct ggtctgcgat
     1921 tcacacaatt ggctggaaca ataccgtttg gttaagccgt tgggaatgta tctctaaatg
     1981 ggttgccact attatttgtg gcttattcgc tgttatcaca gttatcttct acctgaacgg
     2041 tgtaggtgct taatttcgga tattattttt tcaatttgaa aataaaacat tatgactcaa
     2101 atagattcta aaattcctca aggcccgttg gctgagaagt ggacaaatta taaaaatcac
     2161 cagaaattgg tgaatcccgc aaacaaacgt cgtttggaca taattgtagt aggtactggt
     2221 ctggcgggtg cttctgctgc tgcctctctg gctgaaatgg gattcaatgt attgaatttc
     2281 tgtattcagg actctccccg tcgtgcacac tctatcgctg cacagggcgg tatcaatgcg
     2341 gcaaagaatt atcagaatga tggtgactcg gtttatcgtc tgttctacga tacaatcaaa
     2401 ggtggtgact accgtgcccg cgaagcaaac gtctatcgtt tggctgaagt gtcaaactct
     2461 attatcgacc agtgcgtagc acagggtgta ccattcgctc gcgaatatgg tggtctgttg
     2521 gataaccgct cattcggggg tgctcaggta tcccgtacgt tctatgctcg tggtcagacc
     2581 ggacagcagc tgctgttggg tgcttactct gcattgagtc gtcagattgg tttgggaaag
     2641 gtgaagatgt acacacgcca tgaaatgctg gatgttgtga aggttgacgg acgtgctcgc
     2701 ggtattattg cccgtaattt gattaccggt aagatcgaac gttttgccgc tcacgcagtc
     2761 gttgttgcga caggtggtta tgtaaataca ttcttcttgt ctactaacgc gatggcgtct
     2821 aacggttctg ctgcatggca gtgctacaag aaaggggctt actttgctaa tccttgtatg
     2881 gtgcagatcc acccgacttg tgtgccggtg aaaggtgact tccagtctaa gctgactttg
     2941 atgtcagaat cactgcgtaa cgacggccgt atctgggttc cgaagaagct ggaagatgcg
     3001 aaggcattgc aggccggaac aaaaaaggga aaggatattc ctgaagcaga tcgcgactac
     3061 tatctggaac gtcgttatcc ggcattcggt aacttggttc ctcgtgacgt ggcttcacgt
     3121 gccgctaaag aacgttgtga tgccggtttc ggtgtaaata gcacgggctt ggctgtattc
     3181 ctggatttct ccgatgctat caaccgtctg ggtaaggaag tggttaaaca gaaatatggt
     3241 aacctgttcg atatgtacga agagatcacg aacgatgatc cgtacgaaac tccgatgatg
     3301 atttatcctg cattgcacta ctcaatgggt ggtttgtggg tagactatga attgatgact
     3361 tctattccgg ggctgttcgc aattggtgaa gccaacttct ctgaccacgg cgctaaccgt
     3421 ctgggtgctt ctgctttgat gcagggattg gccgatggtt acttcgtatt gccttacacg
     3481 atccagaact atctgtctga ccagatccag gttccgcgct ttagcactga cctgcctgaa
     3541 tttgtggaag cagaaaaggc tattaacgcc cgtatcgcga agttgatgaa cgtgaagggt
     3601 aaagaaacag tcgattctat ccaccgtaag ctgggacata tcatgtggga acacgtcggt
     3661 atggcacgcg acgcggaagg cttgaaagaa gctatccaaa tgttgaaaga cctgaagaag
     3721 gaattctgga gcaatgtatt cattccgggt gaggccaata gcttgaacgt ggaattggac
     3781 aaggcattgc gtttggctga ctttatcgaa atcggtgcgt tgatggcaca cgatgcgtta
     3841 gaccgtgcag aatcttgtgg tggtcacttc cgtacggaac atcagaccga agaaggcgaa
     3901 gctatgcgtc atgacgataa gttcatgtac gtctcttgtt gggaatacca gggtgaagac
     3961 aaagacccgg ttatgctgaa ggaagatttg aactatcagt tcgttgttcc tcaaacacgt
     4021 aactacaaga agtaataatc atcaatcaca aaaattagaa tcatggataa agatataaag
     4081 gtaacactta aagtttggcg tcagaaaggt ccgaaagata aaggacagtt tgagacttac
     4141 caaatcgaca aaatcaatca gagtgtttct ttcttggaaa tgttagacat tttgaatgaa
     4201 cgtttggtta gcgaaggcaa agaacctatc gtattcgacc acgactgccg tgaaggtatc
     4261 tgcggtatgt gttcattgta tgtaaacgga catccgcacg gaccggcaac aggtgcaaca
     4321 acctgtcagc tctatatgcg ccgtttcaat gatggtgaga cgattacgat cgagccgtgg
     4381 cgttctgctg gtttcccggt aatccgcgac ttgatggtag accgttatgc ttatgataag
     4441 attatccagg caggtggttt cgtttctgta aacacaggtg gggttcctga tgctaatgca
     4501 attcctattt ctaaggctga tgcggatttg gctatggatg ctgctgcttg tatcggctgc
     4561 ggtgcttgtg ctgctgcttg taagaacggt tcagctatgc tgttcgtctc tgcaaaggtt
     4621 agccagctgg ctcttttgcc tcagggtaag gtggaagctg ctcgtcgtgc aaaagcaatg
     4681 gttgctaaga tggatgaact gggctttggt aactgtacga acactcgcgc ttgcgaaatg
     4741 gaatgtccga agaacatctc cgttagcaac atcgctcgct tgaaccgcga gttcatctct
     4801 gctaagttac aagactaata cattatatat gtatgtatat ggaaaagccc gtcgccaatg
     4861 gcaacgggct ttctttatgt tcgttcaaac ccacaaaaaa gccgcactcc ctataataaa
     4921 agtggatgcg gcttttttgt tgctttccag tgaaacagtc tctcgattcc ctctctgcaa
     4981 agactttgtt aaccttagat ctaaaatact atgaaaaaaa ctcactgcaa atataaagta
     5041 tatttactga atacgcaaga gtttgtaatt acattttatt gcaaatttgc tactttttgt
     5101 tttaaaattg acactgtgtg cggattcaca ctgttattat atcaacaatc gatcgattct
     5161 gacacttgag agtcgctttg aaatccgtat cctgtatgaa atttgtcggg gatggaatcc
     5221 agaatgtcga ataatgcttc cactgtttcc gcacgtagca tggcgacgcg tgtctgcttg
     5281 aagtctgcaa tacctttaaa cagcggagtt gcagccaaat ggcggcgaat gtggagaatt
     5341 ccccggcgct catccaaacg ttccacgctt tgttccacct gctttttcag tatgtccaga
     5401 taccatgaaa aagattcggc aggcaatgtc tcgcctgtat ccagataatg cctcacttct
     5461 ctgaaaatcc aggggcggcc tatgctgccc cggccaatca taacggcatc cacgccatat
     5521 tgttcgaaac gttgtttgca gatttcggcg gaagtcacat cgccattgcc gatgatggga
     5581 atttgtatac ggggattgtt ttttacttca ccgatcagtg tccagtctgc ctctcctgtg
     5641 tacatctgtg cccgggtacg tccgtggatg gaaagggctg cgataccgca atcctgtagc
     5701 tgttcggcca agtctacgat gatccggttg tcggcatccc agcccaagcg ggtttttacg
     5761 gtgacaggga tgttcaccgc tttgacgact tcacgggtga tgtccagcat cagtggaata
     5821 ttgcgcagca tgccggcgcc tgctcctttg cctgccactc gtttgacagg gcaaccgaaa
     5881 ttgatatcga gaatgtccgg atgagcggct tcgcaaattt gcgcggcttc gaccattgtc
     5941 ggaacatcac ggccatatat ttgtatggcg accggacgtt cttcatccgc cacattcagc
     6001 ttttgctgtg ttttatttac actgcggatt agggcgtctg ctgaaacgaa ttcggtataa
     6061 accatatcgg caccaaaacg tttgcacatc aaccggaaag aaatatctgt aacgtcttcc
     6121 atcggagcta agaagacggg gcgttcgcct aaatctattg tacctatttt catatttata
     6181 ttatcaatga cggggacaaa ggtactgatt tcctgctaaa aacagggata aaaggatatc
     6241 tactaaaaaa tatagtaaaa taactatatg atatagttgt gttactaaat aatatagttg
     6301 tatttgtgca ttcctctaac aaaaaacgga ttatggttag attaacatca aaagaagaag
     6361 aaatattggg ctacttttgg gcgaaaggcc ccctgttcgt tcgcgaacta ctcgacttac
     6421 aggaagaatc taagccgcat tataacacct tgtccacgat tgtccgctca ttggaagaaa
     6481 aaggatatat cggatacaag gtatacggta atacgcacca atactatgca ctggtatcgg
     6541 aagacgaata ccggcgtaat tccttgaaac aggtgatcag caaatattat gacaactcgt
     6601 acacccgtgt cgtttcgacg ctgatagaag aagaggtgct cacgatcgac gagttacaga
     6661 agctgatcca gcagataaaa aacaaataaa aaaccaacgc ttatggacgc ttttcttcta
     6721 tacatattaa aatctggtat ttgcctgaca gtcttttatg tctgtttcaa ggcattattc
     6781 agtaacgaca cgtttttccg gttcaaccgc tggatattac tggtagggac aggagtttgc
     6841 atgttgctgc cactttgccg gatccaaaca gcccggcctt ttcctcttag ccggccagtc
     6901 agccaactgg agatagtttt ctatgaagaa gagatgaaag cgtttcctgt tccggaaagc
     6961 aaagaagaaa ttacgattcc gacagagcag agaaatatat ctgttccctg gacgggaatt
     7021 atcgggattg cttttctaac aggcagtggt atctgcctga ccacaacgat tctgtcattc
     7081 ggaaaaatgt atcaactaac aagaaaaaac aggaaactaa aacaggggaa atacacgtta
     7141 atcctgactc ccgatcccgt atcccctttc agttggggac gttatatatt cctttcggaa
     7201 aacgattacc ggaaccatcc gaacgaaatc ctcatgcacg aaaaaatgca cctccgctat
     7261 aaccattcgg tcgatctgat ctatatgaaa cgattcttct tctgcaatgg tttaatcctg
     7321 ccgtatggtt attaaaaagg gaattacggg gcatacacga ataccaggcg gataaaggcg
     7381 tactcagtca aggcatcgat gcaacaaaat atcaactatt actcgtgaaa aaagctgtcg
     7441 gctccagcct ctacactctt gccaacagct tcaatcacag taaaattaaa aaacgtatta
     7501 ctatgatgtt aaaaaagaaa tcaaacaatt gggcccggtt gaagcttgcg ctcctggtcc
     7561 cggtaggctt cgcggcctta agtgcattcg cccgtccgga aacaagtccg ccgccggcag
     7621 cgacaatgac cgacaacatt catctatcga ttaacaaaag tacggtaaat caggaaacga
     7681 tgcaacagga tcatgcagtt ttcctcacct acaaagaatc gggttcggag gatctgaaca
     7741 gtattgtatg caaaactctg gacagaatca gaacacgagt agcggaggga caattcaaga
     7801 acgccctgga agttactgtt aatccggcct tcgacgatat cccggcttct tatctggaaa
     7861 cagtaaaaga tgttttggaa gaaagagata ttaaatgcaa gatcgacatg actgttccga
     7921 atactatcat ggatgatgtt gccaaacctt accgcaaata tgacgatgtg gtttatctga
     7981 ttcagaataa aaagattgtc gcagcactaa gcatcagtaa gtttagtgca aaccagaatg
     8041 atccgaggct ggataagata tccaaatcag cttccttaat tctccaacct gaaaatccga
     8101 aagtatccag acaagaaatg gagaaattaa aaaacttgtt ggacaaaaaa ggattgacaa
     8161 gcgaaatcaa catgaatatt ttcaagatcg gagatgctgc ggctccacct cccccacctc
     8221 ctgccggaca ggttattttc agttaccggg acgggcagcc ggaccaacag ttcgttttat
     8281 acgatcgcca tgccaaaccg ggagccaatc tcggacaacg catagacaag atttacaagg
     8341 acaatattac gaaagtaagt ataaagatta acaaaagtac tcccaaagac ctgttggaaa
     8401 cggttaagca agaactgaaa aagaaaatca attaccctgt ccaatacgag atcctgcaat
     8461 tcgtcgatta aaatcagaaa cacggattat ctatttatca tcctctccgt ttacaaaacc
     8521 tgctccaggg ggtaaacgga gaggaatatt attatcttta ctccttcaaa agaaggattc
     8581 agatgataca caatgtaaag atactctttt tcatttgctt tttcaccgcc tgttcttcta
     8641 ccgaacaaaa agagattgtc accgccggag agctccttcg acaggctgct ttctatgggg
     8701 aaagattgca atttcttccg gcattggaaa cctatcaaca ggcaatcaaa ttggcggaga
     8761 aggagaaaga cagcaccgtc ttttcccttg cctacctgga aatgggaaaa atctatcggt
     8821 atcaatcttt aaaacaaaag gcactacaaa gtgagaaaaa agcattaagc tatatcaaaa
     8881 gtcctgcctg cgattcgcta cggctggaac tttaccggga aataggggat atgtatacct
     8941 tgtccggaca agcagacagt gcctttcact attatgaaat ggctggatgt cggataaaac
     9001 aggcaaagat attgcaacag aatggaagca ataaagaggc tgaaacttta ttaaaaacgg
     9061 agttggaaca aacgattttc ccgaaagaga aagcagaagt atgtctggct ttggctgatt
     9121 tgcagattac tttgggaaaa ttggacgaag ccgaaaagag tttaagtcag gtcccccctt
     9181 cccacccgca tctgtatgct gccctgtccc gcatcgccca aagccgtgga gacagcctgc
     9241 aagctgattt ctaccacaaa agctacctcc atcacttatc cgtcctgcga caggaaaaag
     9301 aacaaaatca aattacccaa ctccttcgta cctcggaaca gaaagaatgg gaaaaacgtt
     9361 taaccgatag ccaaaaggca caaaaagaac aaatatatgt ctgggtcacg ctacttgtct
     9421 cttgcagtac cggaatctgg ggatattccc gctaccggca gaaaagaaat gtcgtttccc
     9481 tgtccgaaac agatttcttt tcttcagaaa tctacctgcg cttccaccga aaagaagaat
     9541 ggaaaccggt tcccaaagac tgggaagaat tgttgcaagc tttcaaccgg acctatccgg
     9601 atttccggga acggctgaaa aggaaaatac caaagttgag cgaacaggaa tggcgcatgt
     9661 gctgcctgat caaaatggaa gttccccctt ctactgccgc catgctcctt tgctgcacga
     9721 accaggcgat ttcgatgcgc cgcgtacgcc tgtaccagaa aatcacaggt gaaaagggca
     9781 ctcctgagct gtgtgattcc tttattcgtg atttttaagc agatgtgaac tgatgtgaaa
     9841 ccggggaaat agccgtatct tctacttttg tctaaaaaaa gcgtatgaaa aagatgttgt
     9901 tcgggcttat gacagccatt gccactttta ccggatgcga atccaaacaa cccgccggag
     9961 aactcccccg gatcgatctg acagcaacaa gttttgcttt cgatcaagta gagattgcag
    10021 acgaaatcga atccatcgaa tatgttccgt tggaactaac ggatgaatcc ctgatcgcag
    10081 acgtattgga tctgtgtgtt tcagacgaat atatcttcgt ctattctacc cgtcaggacg
    10141 gtgtcttgca gttcgaccgg aaagggaagt acttgcgctg catcgctaaa acaggaaacg
    10201 ggccgggaga aaccggacag atcatttcgc taaccgtaga cgaagagaac cgcctcttct
    10261 gtgtcagcga atacttctcc acctctttct actcctttga tggagaattt atcaaaaaga
    10321 tagagaatcc gcgcccttac tcgtaccaat tctctgttgg cccgaatacg atggcggaat
    10381 tagggaggat gtatgttccc atgaacacgc cgggcatgtt cagtctcgga gtctttaatt
    10441 ggggcacaga cgatacgatc gcattccggc atacgatcgg ggatatggat ctgatgccgt
    10501 tggaagaaac gagcctgaaa ggttggatat tcagcggcag taaggacggc atactatgct
    10561 attcggaagg gatagacacg gtctgggatg taaatgcaag aaatatcgct ccggcttttc
    10621 ttatcaacac gggatattct gtcgaggaag aaaaagaaat gcgctcttcc aaaaccggta
    10681 atgaggcggt agacgggaaa tatagcgtct tcagcttctt tgagacaccc cggcattact
    10741 tcgttaaatg tttcgaaggt tccaaccaat ccaaattcta tttgtacggc ttggataagg
    10801 ctaccggtga gttgaaacgt gaaacttctc cgcttaatgc ccaggaatta ttcaaaaaca
    10861 actggacgct ggcaggaata ggcttccgaa atacgaaaga caacggtctt cctatctggc
    10921 cttacctgtc ttatcccggc aaaaaacaaa tggtacagtt taatacagcc gtggaaatcg
    10981 aatatctcaa agagaaatat cctgatctca agaagcatct ggtcctgcaa cagataacgg
    11041 aagattcaaa tccgctcatc acgatttatc atttgcgctg atcttctcgg atattattcc
    11101 tacctttgcg aacgaaccag taaatgtata agaacttgaa cgagaaagat tttgaaataa
    11161 tggcgcctgt cggttcgtac gaatcactga tggcggctat ccaaggggga gccgattcta
    11221 tctatttcgg tatcgaagga ttgaatatgc gttcgcgctc ttccaataac tttacgacag
    11281 acgatttgcg caagatcgtt gcgctttgtc gtgagcacgg tattaagagc tatttgaccg
    11341 tcaatacggt tatttatggg gaagacctgc ctctgatgcg cgagattatc gatgcggcga
    11401 aggaggcgga agtttcagcg atcattgcgg ccgatgtggc agctatgaac tatgccaaca
    11461 gcatcggaca ggaggtgcat ctttccacac agctcaacat ttccaatgcg gaagcactga
    11521 aattctatgc ccgttttgct gatgttgtcg tcttggcgcg tgagctgaat ttgaaacagg
    11581 tgcatgaaat ctatcggcag atcgtcgacc agcagattac gggaccgaaa ggagaactga
    11641 tccgtatcga aatgtttgcc cacggagctc tctgtatggc cgtttccggt aaatgttacc
    11701 tgagcctgca cgaaatgaac gcttccgcca accggggagc ttgcatgcag atttgtcggc
    11761 gtgcttattc ggtaaaagat aaagacagca atatcgaact ggatatcgaa aaccagtata
    11821 ttatgtcgcc taaagacctt aagacaattc atttcatgaa taagatgatg gatgcaggtg
    11881 tacgggtatt caagatcgaa ggacgtgccc gcggtcccga atatgtccgc ctggtgaccg
    11941 aatgctataa ggaagctgtg cgtgcctatt gcaatggcac gttcgatgaa aagaaagttg
    12001 ccgcttggga cgaacgcctg cgcagtgtgt tcaaccgagg attctgggat ggctattatt
    12061 tggggcaacg gttgggtgag tggagtagca aatatggctc cggcgcgact aagaagaaag
    12121 tgtatgttgc caaaggaatc aaatatttcg acaagatcgg cgtggcggag ttcgaaatgg
    12181 aatccggtaa cctgaaagtg ggtgatgaga tcctgattac cggaccgaca acgggtgcgg
    12241 ttatgcagac gatagaagaa atccgtgtgg acttgaagcc ggtggacgag accgttaaag
    12301 gtgaacggtt ctctctcaag gtgaacgaga agattcggcc gtctgaccga ttgtataaaa
    12361 tggaaaaggt tcaacttgaa aaggtatttg aataatgaaa gagtatattt ttaaactgac
    12421 agacaaggtc cgtgactacg aatgcgacct gcaaggagtg gtcaacaact ccaattatca
    12481 gcattatatg gaacatactc ggcatgaatt cttggagtcg cttggcgaga acttcggaaa
    12541 gatgcacgaa aaaggggttg acggatttgt atcgcgggta gaaatccagt ataagacctc
    12601 gctcaagagc ggcgacagct atatctcttg cctcaatgcc tataaaaaag gagtcaagct
    12661 cgtattcgag caggatatat atagggcttc tgacaatgca ttggcgacga aaggaatcgt
    12721 cgagtcggtt atcgttgaga acggaaagtt gacacgcggt gaatatttcg acgaaatgct
    12781 aaaaagaata gaacatacat gactgacaaa cggatttacc aaatcggcct tactatgata
    12841 aacggcgtgg gagatatcct ggcgcgtcat ctcctgcagg ctttgggaga agcagaggct
    12901 gtgtttactg aaaagcaaca gttgttagga aggatccctg gtatcggcag caatattgct
    12961 gccgaaatca aacgcccgga aatcttgcaa cgggcggaaa aagagttggc ttttatcgag
    13021 aaaaacaata tttcctgtta ttatctgact gatacagatt atccggtgcg cttgagagaa
    13081 tgtccggatg cccctatact tttctatttt aagggaaata ctaaccttga tgcgacccgt
    13141 atcatcagta ttgtgggtac tcgcaacgcg accgaatatg gtcgggagct taccgaatcc
    13201 cttataaaag acttggcaaa agtgatcccg gacttgttgg tcgtgagtgg attggcttac
    13261 ggcatcgata tctgtgctca ccggaacgct ttgtacaacc gacttccgac tgttgctgtg
    13321 ctggcgcatg gcttggatcg tatctatcct tcctgccatc ggaatacggc tgtcgaaatg
    13381 ctggaatcgg gcggtctgtt gaccgatttt cccagcggta cagaaccaga ccgtccaaat
    13441 ttcctccgga ggaaccggat tgtcgccgga atctcggatt gtacgatcgt ggttgaatcg
    13501 gcagaaaaag gaggctcttt ggtaactgcc gatattgcat tctcttatgg ccgggatgtc
    13561 tatagctttc cagggcgtgt cggtgacagc cattccaaag gatgcaacaa tttgatccga
    13621 caaaataaag ccggcctgat cacttctgcg gacgatctgc tctccgctct ttgttgggat
    13681 atccaagctg gggctactcc cgttcaaacg gagttgtttt tcgccgaagc ggaaacattc
    13741 acctcggaac aaaatccggt tttagccatt atgcgaacgc ggaatgagat tcatatcaac
    13801 gagcttgcct cagtgttgga gataccggta catcaactct ctatgctatt gttcgaactg
    13861 gaaataaacg ggaaggtaaa agcgttgccg ggaaatctct ataagctgtc ctgaccggct
    13921 ttttcgtata cgatttgtat gtgggagaag aaacggaacc tctataaaca attaaaggct
    13981 gtctcacgac aacccctaac caactttgtt aaccttaaat ctaatactat tatga
//
