LOCUS       c00170_gnlPro..        16551 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JFAGBGHC_170.
ACCESSION   c00170_gnlPro..
VERSION     c00170_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 17:38:36
            Original ID  :: gnl|Prokka|JFAGBGHC_170
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 25411
            Orig. end    :: 41962
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16551
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[35411:40120]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14709
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..16551
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16551
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             419..1507
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GCV_T"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GCV_T_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg170_17"
                     /sec_met_domain="GCV_T (E-value: 7.7e-97, bitscore: 314.6,
                     seeds: 72, tool: rule-based-clusters)"
                     /sec_met_domain="GCV_T_C (E-value: 1.4e-24, bitscore: 76.9,
                     seeds: 348, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTTPFTEKHISLGAKMHEFAGYNMPIEYSGIIDEHLTVCQGVGV
                     FDVSHMGEFWVKGPHALDFLQKVTSNNVAALTPGKVQYTCFPNENGGIVDDLLVYHYEP
                     EKYLLVVNASNIEKDWNWCVSHNTEGAELENASEHMAQLAVQGPKAIQALQKLTSINLS
                     DLPYYTFTHGEFAGEKDVIISNTGYTGAGGFELYFYPEAAMKIWDAVFEAGAEFGIKPV
                     GLGARDTLRLEMGFCLYGNDLDDTTSPIEAGLGWITKFVEGKNFTNRPMLEKQKAEGTT
                     RKLVGFEMIDRGIPRHGYELYSTDGIAIGVVTSGTMSPTRKIGIGMGYIRPEYSKVGTE
                     ICIDMRGRKLKAVVVKPPFRKQ"
     CDS             complement(1598..2359)
                     /locus_tag="ctg170_18"
                     /transl_table=11
                     /translation="VAYWDDNEDAYAVSLVADIGAIASLLSIPATDRLGMKYKTSQEIS
                     SDRLARQLLAFKGYNPDGIASALSKIIGYYNLHQRNKDIPRYGSIGDLQKRIEKAGESH
                     SLSARPYLRTTSDVVSFNASMNYANKRYKETARLIRKNIDNRLATDNDYIILVKAEMAL
                     SNTEEVNNRCLAMLDKAQEMAGTSPNLDIYKQKILLLMRMNKQAQATDILKEYIILLSA
                     YEGQGIEGTEKEWTNKEIGWANQMLDRISRI"
     CDS             2453..3043
                     /locus_tag="ctg170_19"
                     /transl_table=11
                     /translation="MVEDEMSQLTCDDGGQFVFGIKSAEEARTDNHGAVGKHEGIWFGR
                     LDDTYVQTLPAIAVNGGGVQLGEHSLHVRNDVIFLIGYLIQFVEIVQALFVDFLAQFVL
                     VAAVAEIFVKMVFQVYLLPEFPVGLRSGYGNVPHLIRRNGLLHAVHFDSIVNVVAAFTG
                     ILHFDNPADNDRCTGGRLPVLFCQFSFDSDVPA"
     CDS             complement(3307..3639)
                     /locus_tag="ctg170_20"
                     /transl_table=11
                     /translation="LRSEKKTITLFITKIVTEYKFLKENIKMKKGIHPENYRPVVFKDM
                     SNGDVFLSRSTCNTKETIEFEGETYPLVKLEISSTSHPFYTGKSKLVDTAGRVDKFMSR
                     YGNRKK"
     CDS             complement(4305..4796)
                     /locus_tag="ctg170_21"
                     /transl_table=11
                     /translation="MFALRHLFTHYYVILIFQIDDGRQMVTVTVQPSPAPMRTQGGTFV
                     FAILLNQIIADENFIVIIAQPFLSLQQRFRNDNLVKQVPLAPIEQCPHSLVFQCLPPGI
                     VEFAFLHLLRIFACTQHLHAFIHRVVIHIPHHDEFQLLVATHQRVLQGLYLPGCMHTHR
                     "
     CDS             5037..6047
                     /locus_tag="ctg170_22"
                     /transl_table=11
                     /translation="MVNYKDLGLVNTREMFAKAIKGGYAIPAFNFNNMEQMQAIIKAAV
                     ETKSPVILQVSKGARQYANATLLRYMAQGAVEYAKELGCKHPEIVLHLDHGDTFETCKS
                     CIDSGFSSVMIDGSHLPYEENVALTKKVVDYAHQFDVTVEGELGVLAGVEDEVSAEHHT
                     YTNPEEVIDFATRTGCDSLAISIGTSHGAYKFKPEQCHVDPATGRLVPPPLEFAVLDAV
                     MEKLPGFPIVLHGSSSVPQEEVDTINKYGGKLEAAIGIPEEQLRKAAKSAVCKINIDSD
                     SRLAMTAAIRKTFAEKPAEFDPRKYLGPARDNMEKLYKHKIINVLGSENKLAQLD"
     CDS             complement(6518..8308)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg170_23"
                     /sec_met_domain="Alpha-amylase (E-value: 4.8e-64, bitscore:
                     207.9, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVNKIDPPFWYTGMQNPELQLMVYGEGIGNAAVSVNYPGVSLSS
                     TVKLESNNYLLVYLKLDKDVKPGKFNLTFTEGKKKLVKEYELKARNKKGCEHKGFDASD
                     ALYLLMPDRFANGNPDNDQIAGMAEYKIDRKDPNARHGGDLAGIEQHLDYFSDLGVTAL
                     WFTPVLENNMTGGSYHGYATTDYYKVDPRFGTNEEYKQLIEKAHARGIKIVMDMIFNHC
                     GVEHVWIKDMPSKDWFNNPDHENNFVQTSFKLTPHVDPYTSQYDADQMNDGWFVPSMPD
                     LNQKNPHVYRYLVQNSFWWIEFANIDGIRMDTYPYADYDAMSNWMKELNEEYPNYNTVG
                     ETWVTEPAYTAWWQKDSKLSAPKNSNLKTVMDFSFFDKINTAKNEQTETWFKGLDRIYN
                     NFVYDFLYPNPASVLAFIENHDTDRFLGEGNNLPMLKQASTLLLTTRRIPQLYYGTEVM
                     MNGVKSKSDGYVRKDFPGGWTGDATNALTPAGRTKIQNECYDFYKTILNWRKGNDVIAK
                     GSMVQFMVQNGVYAYARQYEGKTIFVMLNGTDAETTVPLKFYKEILKDSKQGKDILSGK
                     AITFGEELKMGPRESLVIEL"
     CDS             complement(8479..9747)
                     /locus_tag="ctg170_24"
                     /transl_table=11
                     /translation="MANYDYETALMLIDQETPTVPLLYQKGKALKGLGNNLEALSVFQE
                     VVAQDSLNPRAYIEAAECCKSLAKYSEALDYYQNALHINPDNKYARIQYISLLMNMKRY
                     RESLKESNLLAERDSSAYVLHLRAESMGQVYDNTEIMHVIDAYLDIQKRYPNDYLSAAK
                     LGNIYVAGHQYEDAINITEKYRSIDSTNVLVNRINAQAYCLNKDYPKAIERYEQLLQEK
                     DSSFQTCFYAGISYYALEDFYPAHDLLERALKDDNTNINVLYYLGRACSKTSWKEDGVT
                     YLETAVSLAMPSDSVMSRLYVGLADCYKMAFQYTDQANTLLTQYEKYDRQKHKLLYDAA
                     FIYYYYLKDVSKAERYLTAYLKTRPKNSKDKVQEVDADGVPIIGEDNRYNAAENWLKDI
                     REKRKKEDFFKGKVDTASVTPIK"
     CDS             complement(10001..11161)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg170_25"
                     /sec_met_domain="OAD_beta (E-value: 1.2e-152, bitscore:
                     498.9, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGEFITFLGNNLADFWTYTGFANATVGHVVMLLVGLFFIYLAVAK
                     EFEPMLLIPIGFGMLIGNIPFNMEAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLVGAAAQFGIFGAYMIALAIGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRWLTSKNERLIRMKPPRVVSHTEKVMFP
                     IIGLLLTTFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDTITILLGLTVGAS
                     TQASEFLTLDSIKIFGLGALSFVIATASGVIFVKIFNLFLKKGNKINPLIGNAGVSAVP
                     DSARISQVVGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             complement(11163..11597)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 67.3; E-value:
                     2.7e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg170_26"
                     /sec_met_domain="Biotin_lipoyl (E-value: 1.3e-21, bitscore:
                     67.3, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNVYKVAIGDIEDNIAHVEVNGTPYKVEMEKAPKVV
                     VKPVARPAATSAPAAPATPVVKPAAASTGKSGVKSPLPGVILDIKVNVGDTVKKGQVII
                     ILEAMKMENNINADKDGKITAINVNKGDSVLEGTDLVIIE"
     CDS             complement(11621..12553)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg170_27"
                     /sec_met_domain="OAD_gamma (E-value: 2.5e-17, bitscore:
                     54.3, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKIGIFLSLMLVLGFCSSCKEQKSNNKLLLNEVLVNNESNYQ
                     DDYGVHSAWIEIFNRSYGSADLAGCYLKFSSQPGDTASYFIPKGDVLTLIKPRQHALFW
                     ADGEPRRGTFHTNFKLDATNANWIGLYDSGKKLLDQVIVPAGTLKANQSYARVSDAADQ
                     WEVKGGSEDKYVTPSTNNKTIDSNAKMEKFEEHDSVGIGMAISAMSVVFCGLILLYISF
                     KIIGKISVNLSKRNAMKAKGITDKQEAKEKQLGQAPGEVFAAISMAMHEFQSDVHDVED
                     TILTITRVKRSYSPWSSKIYTLRETPHKK"
     CDS             complement(12585..14138)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg170_28"
                     /sec_met_domain="CT_Btheta (E-value: 3.1e-291, bitscore:
                     956.9, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIDRRAAARLGGGEKAIAKQHEKGKYTARERIAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYIFAQDFTVSAGSLS
                     ETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAQTEEEGLALIRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDNPN
                     KPYDMYEVIGAIIDNGEFLEIQKDYSKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKEQENPAQFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRIIRALQQLQTKKLTNPAKKHGNIPL
                     "
     CDS             complement(14197..14709)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg170_29"
                     /sec_met_domain="Glyoxalase_4 (E-value: 9.7e-26, bitscore:
                     81.2, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNFFIKEEFSFFVLLYTFIKKDTILTLIYIVMKISHIEHLGIAV
                     KSIEEALPYYENVLGLKCYNIETVEDQKVRTAFLKVGDVKIELLEPTSPESTIAKFIEK
                     NNGNGGMHHLAFAVEDGVAGALAEVEEKGIRLIDKAPRKGAEGLNIAFLHPKSTLGVLT
                     ELCEKPE"
     CDS             14939..16390
                     /locus_tag="ctg170_30"
                     /transl_table=11
                     /translation="MPLATMAQNDTLGHERNITLSEAIVLARTQSVDAAVALNELKTAY
                     WEYRTFRADLLPEVNFTGTLPNYNKSYSTYQNSDGSYSFVRNNTLGLSGQLSVDQNIWF
                     TGGKLSLTSSLDYLKQLGSGGAKQFMSVPVSLELTQPVFGVNTLKWNRRIEPVRYAEAK
                     AEFISATEEVTMKTITYFFELLLAKESLATAMQNKTNADRLYEVAIAKRKMGQISENDL
                     LQLKLNSLQGKADVTEAESNLNAKMFQLRSFLGVSEQESLNPVLPATVPDIKMEYDRVL
                     NKALERNSFAQNIRRRQLEADYEVATARGNLRSIDLFASVGYTGQNHEFSSAYRDLLDN
                     QIVQVGVKIPILDWGKRRGKVRVAKSNREVVLSRIRQEQMDFNQDIFLLVANFNNQAQQ
                     LDIAEEADVIAEKRYKTSVETFMIGKISTLDLNDAQNSKDEARQKHISELYYYWYYFYQ
                     LRSLTLWDFERDTELEADFEEVVRG"
ORIGIN
        1 atccgtgacc acgaccgcac ccgctttgaa gagcgcaaga aggagatgga acgtcttgtg
       61 gcaaaaatca atgaagaata cggtccgggt accgctactc tggaacttcg cgaccaatac
      121 tataatatgc gcgagcagat tgaaccggtg atgcatatca tcgacaccgc ttttgccgcc
      181 atgaaggcag taggtgtaga gcctcgtgta aaagccattc gcggaggtac ggacggcgcc
      241 cagctctctt tcaagggcct gccttgtccc aatatctttg ccggtggctt gaacttccac
      301 ggccgctatg agttcgtgcc tatccagaac atggagaaag ccatgaacgt catcgtcaag
      361 attgccgagc tcgtagcaag caaatagata attcataact cataactcta atagttccat
      421 gaaaaccact ccgtttaccg aaaaacacat ctcgctgggt gccaagatgc acgagtttgc
      481 gggatataat atgcctatcg agtattccgg catcattgac gagcatctta cagtatgtca
      541 gggtgtcggt gtattcgacg tctcacacat gggagaattt tgggtgaaag gtccccatgc
      601 tttggacttt ctgcagaaag tgacttccaa taacgtagct gccctcacac cggggaaagt
      661 acagtatacc tgcttcccaa atgaaaatgg aggcattgtg gacgaccttc tggtctatca
      721 ttatgagccg gagaaatacc tgcttgtcgt gaatgcgtcg aacattgaga aagactggaa
      781 ctggtgtgtg tctcataaca cggaaggcgc tgaattggaa aatgcttccg agcacatggc
      841 acagcttgct gtgcaaggac cgaaggctat tcaggctttg cagaagctga cttccattaa
      901 tctttccgac cttccttact atacttttac ccacggtgag tttgccggag aaaaggatgt
      961 cattatctcc aataccggat ataccggcgc gggtggtttt gaactttact tctatccgga
     1021 ggctgccatg aagatttggg atgccgtgtt cgaggcaggc gcagagttcg gcattaagcc
     1081 agttggtctg ggtgcgcgcg atacgcttcg tctggaaatg ggattctgtt tgtatggcaa
     1141 tgatttggat gacaccactt cgcccattga agcgggttta ggatggatta ccaagtttgt
     1201 ggagggaaag aacttcacca atcgcccgat gctggaaaaa cagaaagcgg aaggcactac
     1261 ccgtaagttg gtgggatttg agatgataga ccgcggtatc ccccgtcatg gttacgagct
     1321 gtatagtaca gacggtattg ccatcggtgt ggttacctcc ggaactatgt cgcctacccg
     1381 taagattggt atcggaatgg ggtatatcag acccgaatac agcaaggtcg gtacggaaat
     1441 ctgcattgac atgcggggac gtaagctgaa agctgtggtt gtgaagccgc cgttccgcaa
     1501 acagtagttt gaataaatga ctgagaatga agaatttggc tgcgcaatga tgccgcatga
     1561 caaattcttc attctttatt cttagttatt cctttctcta tattctgctt atcctatcca
     1621 gcatttggtt tgcccaacct atctctttat tggtccattc cttttcggtt ccttctatgc
     1681 cctggccttc gtaggccgaa agcaagatga tgtattcttt cagtatatcg gtggcttggg
     1741 cttgtttgtt catgcgcatc aataatagta ttttttgttt atatatgtcc agattggggc
     1801 ttgttcctgc catctcctgg gctttatcaa gcatggcgag gcagcggttg ttcacttctt
     1861 ccgtattaga cagtgccatt tccgctttta ccaggatgat gtagtcattg tccgtggcta
     1921 gtctgttgtc aatgttcttg cgtatcagcc gggcagtttc cttatagcgc ttgttggcgt
     1981 agttcatact tgcgttgaaa gaaacgacat cgctggtagt ccgtaggtag gggcgggcac
     2041 tcaagctatg ggattcaccg gccttttcta tacgcttttg caggtcgccg atgctgccgt
     2101 agcgaggaat gtccttgttg cgctggtgca ggttgtaata ccctataatt ttactgaggg
     2161 ccgatgcgat tccgtcggga ttatagccct tgaatgccag aagttggcgc gcaaggcggt
     2221 ctgaagagat ttcctgggaa gttttgtatt tcatccccaa ccggtccgtt gccggaatgc
     2281 tcaaaaggga agcgatggct ccgatatctg ccaccagact gacggcataa gcatcttcat
     2341 tatcgtccca gtaggccaca tcgagggctg cactggcggt agtggcaaag acatctgccc
     2401 aaaaagctgc acgcttggca cgccgctcgg cacggtaaat gttgtttacc tgatggtcga
     2461 ggacgaaatg tcccagctca catgcgatga cggcggccag ttcgtcttcg gaatcaagag
     2521 tgcagaggag gcccgtactg ataaccatgg agccgttggg aagcatgaag gcatctggtt
     2581 cgggcgactg gatgatacgt atgttcaaac tctccccgcg attgctgtca atggtggtgg
     2641 cgttcaactt ggagaacact ccctgcacgt acgaaacgat gtaatcttcc tgataggcta
     2701 tctcattcag tttgtcgaga tagtccaggc actcttcgtc gatttcctgg cgcagtttgt
     2761 gcttgtagcc gcggtcgctg aaatattcgt aaagatggtt tttcaagtat atctgctgcc
     2821 agaattcccg gtcggtttgc ggagcggata tggcaatgtg ccccatctca ttcgaaggaa
     2881 tggtctcttg catgccgttc atttcgacag catagtaaat gttgttgctg ctttcaccgg
     2941 gattcttcat tttgacaacc cggcggataa tgaccggtgt accggcggga gattgccggt
     3001 actcttttgt caattctcct ttgacagcga tgttcccgct taaatctttg tacttttggg
     3061 gcttggcaaa tcctgccgtt gcgacaagga ttgtcaggat gaatagggtg gcaagtcgtt
     3121 tcatgattag tatatgtttt cggttttgat gatacaaaaa tagggaagtg ttttttccct
     3181 ttctcgtttt tttccctatt ctgtgatagg agattcccta tttatcggtc ctgcagtggg
     3241 aggcggaaac aaaaaaggga acctttcagt gaaagactcc cttttttcag tttgcttgaa
     3301 aactgattat ttcttacggt taccgtaacg gctcatgaac ttatcaacac gaccggcagt
     3361 gtcaaccagc ttagacttac ctgtgtagaa cgggtgagag gtgctggaga tttccagctt
     3421 taccagcgga taagtttcac cttcgaattc gatagtctct ttcgtgttgc aagtggaacg
     3481 agacaagaat acatcaccat ttgacatatc tttaaatact accggacggt aattttcagg
     3541 atgaatacct tttttcattt tgatattttc ttttaaaaat ttatattctg ttactatttt
     3601 ggtaataaat agtgtaatgg tcttcttttc agagcgcaaa gatagtgcaa gttggagact
     3661 ctacaaaata aattcagatt tatttttatt tagtaggttt atcgcatttt atttctgatt
     3721 tttgcaggac ttaatcttgt gaatttatga ggaaactact tgtcttatgc tctttctggc
     3781 tgtgcgtggc aacgctgggg gcacaaaatg cggaacggaa actgtatagt gttgcgttct
     3841 acaatcttga gaacttgttt gatacgattc atgatgcagg taagaatgac tatgagttcc
     3901 tgcccgacgg cagttaccaa tggacggcaa agaagtatga gtccaagctg cagaaccttt
     3961 ccaaagtgtt gggttccctt tcgcgtgatt tagtgccgga aggtccggca ttcatcggtg
     4021 tggcagaggc ggagaacagc cgggtgctgg aagacctcgt gaagcagccg gccatttcca
     4081 attatgagtt cgtgcattat gaaggaccgg acagacgggg catcgactgt gccttgctgt
     4141 acgacccgaa gcagttcagc gttacccact caaagttggt gctttctact ccttttgagg
     4201 gggatacggt gcacttgacg cgcggcttcc tgattgtgga cggacaactg gcgggagagc
     4261 gtgtctgcgt gatagtgaac cactggccct cccgtggggc aaagtcaccg gtgcgtgtgc
     4321 atgcagccag gcaggtaaag gccttgaagg actctctgat gcgtagcgac aagaagctga
     4381 aactcatcgt gatgggggat atgaatgacg acccgatgga tgaaagcatg gaggtgctgg
     4441 gtgcacgcaa atatccgaag caggtgaaga aaggcgaatt ctacaatccc tggtgggaga
     4501 cactggaaga caagggagtg gggacattgc tctatcgggg caagtggaac ttgtttgacc
     4561 agattgtcat ttcgaaaccg ttgctgaagg ctaagaaagg gttgcgctat gatcacaatg
     4621 aagttttcat ccgcgattat ctgattcagc aggatggcaa atacaaaggt tcccccttgc
     4681 gtacgcatgg gggcaggact tggctgaacg gttacagtga ccatttgccg accatcatct
     4741 atctgaaaaa ttagtattac ataataatgt gtaaacagat gccggagagc aaacatgttc
     4801 tccggctttt ttgttgatag aagtatagat ggcaaaagta tggctggcag agataaatgc
     4861 aaagagtttg taatatagag attacaataa tctgttaaat gaagccaata gctttaaaat
     4921 agaatggatt tggtaggatg agccggatat tttattcctc tcaagttctt tactttaaag
     4981 gataatgatt acttttgcgt agaattttaa ttcactaaca ataaaattta aacaaaatgg
     5041 ttaattacaa agatttagga ctggtaaaca caagagagat gtttgctaag gctatcaaag
     5101 gtggatatgc tattccggca ttcaacttca acaatatgga acagatgcag gctatcatca
     5161 aggctgcagt tgaaacaaag tctccggtta ttcttcaggt atctaagggt gcccgtcagt
     5221 atgccaacgc tacgctgttg cgttacatgg ctcagggtgc tgttgagtac gctaaggaat
     5281 tgggttgcaa acatcctgaa attgttcttc accttgacca cggagataca ttcgaaactt
     5341 gcaagagctg tatcgactcc ggtttctctt cagtaatgat tgacggttca caccttccgt
     5401 acgaagaaaa cgttgcactg actaagaagg tagttgacta tgcccatcag ttcgacgtaa
     5461 ctgtagaagg cgaactcggt gtattggccg gtgtagaaga tgaagtttct gcagaacacc
     5521 atacatatac taatcctgaa gaagttattg acttcgctac ccgtacaggt tgcgattcac
     5581 tggctatctc aatcggtact tctcatggtg catacaagtt caaacccgaa caatgccacg
     5641 ttgaccctgc taccggtcgt ctggttcctc ctcctttgga atttgccgtt ctggatgctg
     5701 taatggagaa acttccggga ttccccatcg ttcttcacgg ttcttcttca gttcctcagg
     5761 aagaagttga tactatcaac aagtatggtg gtaagctgga agctgctatc ggtatccccg
     5821 aagagcagtt gcgtaaggct gccaagtctg ctgtttgcaa aatcaacatc gactctgact
     5881 cacgtctggc tatgacagct gctatccgca agacatttgc tgaaaaaccg gcagaattcg
     5941 acccgcgtaa gtatctgggt ccggctcgtg acaatatgga aaaactgtac aagcataaaa
     6001 tcatcaacgt gcttggttca gagaacaaat tggctcaact ggactaatcg aaagataatc
     6061 cgaatatagc gtcagccctt gcaatattga tgttgcaagg gctgacttgt tatatatagg
     6121 ccggtgttgt gggatggtta agttcgccgg ttatttcaga agcggatgtt tcaacgtgta
     6181 caacagtctg tttcctttaa caaaacagtc tgtttccctt aactgaacag tttgtttcaa
     6241 taaagagaac acttcgttcc aatatgcaaa aacacttcgt tccaatacgt aagaacactt
     6301 tgtttctaca tatccgaaca ctttgtttct ctatactgga acaaagtgtt caccgttatg
     6361 aactaacaga ttagctatat ttgagaccgg tgaaaagcat atccccgtga cacctattcc
     6421 atactaaaaa tcccttgcag atggctggca ggcgaggtgt ctgcaagcta tctgcaaggg
     6481 agatttgcaa gaatgagctc tctgtgtgga gtgcgcgtta taattctatc actaatgatt
     6541 ctctggggcc catcttcagc tcttcaccga aggtgatggc cttgccgcta agaatatctt
     6601 ttccctgctt gctgtctttt aggatttcct tgtagaattt caaaggaacg gtggtctctg
     6661 catctgtacc gttcagcatc acgaatatcg tcttgccttc gtactggcgt gcgtaggcat
     6721 aaacaccatt ctgtaccatg aactgcacca tgctgccttt ggcaatcaca tcgtttcctt
     6781 tgcgccagtt taggatggtc ttgtagaagt cgtagcactc gttctgtatt ttggtacgtc
     6841 cggctggggt cagtgcgttt gttgcgtcac cggtccatcc gccggggaag tccttgcgga
     6901 catagccgtc gctcttgctc ttcacgccat tcatcatgac ttccgttccg tagtagagtt
     6961 gcggaatgcg gcgggtggta agcagcaggg tagaggcttg cttcagcatc ggaaggttgt
     7021 tgccttcgcc caggaagcgg tcggtgtcgt ggttttcgat gaatgccagt acggaagcgg
     7081 ggttggggta gaggaagtcg tatacgaagt tattgtatat gcggtccagt cccttgaacc
     7141 aagtttcggt ctgttcattc ttggcggtgt ttatcttgtc aaagaagctg aagtccataa
     7201 cggtcttgag gttactgttc ttgggggctg atagcttgga atccttctgc caccaggcgg
     7261 tgtaggcggg ttcggtaacc caggtctcgc ccacggtgtt gtagttggga tattcttcgt
     7321 tgagctcttt catccagttg ctcatggcat catagtcggc atacgggtaa gtgtccatgc
     7381 ggatgccgtc gatgttggcg aattcaatcc accagaaact gttctgtacc aggtagcggt
     7441 aaacgtgagg gttcttctgg ttgaggtcgg gcatggaagg tacgaaccag ccgtcgttca
     7501 tctggtcggc atcgtactgg gaagtataag ggtctacgtg cggggtcagt ttgaaggagg
     7561 tctgcacgaa gttgttttcg tggtcggggt tgttgaacca gtctttggag ggcatgtcct
     7621 taatccatac atgctctacg ccgcagtggt tgaaaatcat gtccattacg attttgatgc
     7681 cgcgtgcatg ggctttttca atcagttgct tgtattcttc gttggtaccg aagcgcgggt
     7741 ctaccttgta gtagtctgtg gtggcatagc cgtgatagga accgccggtc atgttgtttt
     7801 ccagtaccgg agtaaaccag agggctgtga cgccgaggtc ggagaagtag tccaggtgtt
     7861 gttcgatgcc ggcaaggtca ccgccgtggc gtgcattggg gtctttgcgg tctatcttgt
     7921 actcggccat gcccgcaatc tggtcattgt ccgggttgcc attggcaaag cggtcgggca
     7981 tcagcaggta cagtgcgtcg gaggcgtcga aacctttatg ttcgcaacct ttcttgttgc
     8041 gtgccttcag ttcatattcc tttacgagtt tcttttttcc ttcagtgaag gtgaggttga
     8101 atttgccggg ttttacatcc ttgtccagtt tcagatagac caggaggtag ttgttgcttt
     8161 ccagcttgac ggtgctgctc aatgagacgc cgggataatt gacggatact gccgcgttgc
     8221 cgatgccttc gccatagacc atcagctgga gttccgggtt ctgcatgccg gtgtaccaaa
     8281 acggagggtc gattttgttc acattcatag ctgcatacgt actgagggag agtaagagtg
     8341 ttcccaagat taagaatact tttttcatga tagtaacttt acggttaatt tttgcgctaa
     8401 tttaaaacaa ataacggaga aagttaatct ttctccgtta ctgtacctta ttatattatg
     8461 caaacgtttt cattggggct atttgatggg ggttacgctg gcggtatcga cctttccctt
     8521 gaagaagtcc tctttcttgc gcttttctct gatgtccttc agccagtttt cggcggcatt
     8581 gtatcggttg tcttctccga tgatgggaac tccgtccgca tctacttcct gcactttgtc
     8641 cttgctgttt ttcggacggg ttttcaggta tgccgtcaga tatctctctg ctttggacac
     8701 atctttcaga tagtaataat agataaaggc tgcgtcgtag agcagtttgt gtttctgccg
     8761 gtcgtatttt tcgtattgcg tcagaagggt attcgcctgg tcggtgtatt gaaatgccat
     8821 cttgtagcag tccgcaagcc ccacatatag gcgggacatg acactgtcgc tgggcatggc
     8881 gaggcttacg gcagtttcca gataagtcac tccatcctct ttccatgatg tcttggagca
     8941 ggcgcgtccc agataataga gaacgttgat gttggtattg tcatctttaa gagccctttc
     9001 cagcaggtcg tgtgctgggt agaagtcttc gagggcataa tagctgattc cggcgtagaa
     9061 gcaggtttgg aaagaactgt ctttttcctg taacagttgt tcatatcttt ctattgcttt
     9121 ggggtaatct ttgttcaggc aataggcttg ggcattgatg cggttcacaa ggacgttggt
     9181 ggagtctatg gaacggtatt tctccgttat gtttatggcg tcttcatact ggtggcctgc
     9241 tacatagatg ttgccgagtt tggcagcaga caggtaatca ttgggatatc ttttctgtat
     9301 gtccaggtag gcatctatca catgcatgat ttctgtgttg tcatagactt gccccatact
     9361 ttcggctcta aggtgtagta cataggcgga actgtccctt tctgccagca ggttgctttc
     9421 ctttagagac tcacggtatc tcttcatgtt catcagcaga ctgatatact ggatgcgtgc
     9481 gtatttattg tccggattta tgtggagcgc attttggtag taatccagtg cctcgctata
     9541 tttggcaagt gatttgcagc attcggcagc ttcaatgtat gcccggggat tgagagaatc
     9601 ctgagctacg acttcctgaa atacgctcag agcttcaagg ttattgccca gccctttcag
     9661 cgcttttcct ttttggtaga gtagggggac ggtcggggtt tcttgatcga tcagcatcaa
     9721 ggctgtttca taatcgtagt tggccatcgc ctcttgaatg ggatttgtgg tctgtgccgc
     9781 cagaagcgaa cagcatgcac tgaaacataa ggagataaaa agctttcgca tacagtatat
     9841 catttatatg aggttaaact gactgcaagt tactaaaaag aatgtattta cgaaataatc
     9901 gtaatctgtt ttagatagat taacgaaaaa gcccctccaa aaatgaaggg gctctaaaat
     9961 agttcagaat tcaagccgga taacggaatg aataaatgta ttacattaag aatcccagca
    10021 ggatacctgc tgctacagcg gaaccgatta caccggcaac gttcgggccc atggcatgca
    10081 tcagcagata gttggtagga tcgtattcca gacctactac ttgggagata cgtgcagagt
    10141 cgggtacggc agatacaccg gcattaccga tcaacggatt aatcttgttg cctttcttca
    10201 ggaagaggtt gaaaatcttc acgaagatga caccggatgc tgtggcaatg acaaatgata
    10261 aggcgcccag accgaatatc ttgattgaat caagggttaa gaactcggat gcttgcgtag
    10321 aagcacctac tgtcaaacca agcagaatag taatggtatc aatcagcgga ccactggctg
    10381 tgtttgccag acgacgtgta actccacttt ctttcagtaa attaccgaag aacagcatac
    10441 ccagcaaagg cagaccggat ggtacaagga atgtggttag taacaaaccg ataatcggga
    10501 acattacttt ttccgtatgt gaaaccacac ggggaggttt catacggata agacgttcat
    10561 ttttactggt cagccaacgc ataataggcg gctgtatcac cggtactaat gccatatatg
    10621 aataggctga taccgcaatg gcacccatta agttaggagc cagtttggaa gagaggaaga
    10681 tggcagtcgg accatcggca ccaccaatga taccgattgc accagcctgc atcgggtcaa
    10741 atcctatggc aagggcaatc atataagcac cgaatatacc gaattgggct gctgcaccaa
    10801 ccaacattaa tttggggttc gatatcaaag cagagaaatc cgtcatggca ccgataccca
    10861 ggaatatgag tggcgggtac caaccggagg ttactccctg gtacagaata ttaagtacgg
    10921 aaccttcttc atagataccg acttttaatc cggcttccat attgaaaggt atattaccaa
    10981 tcagcatacc gaaaccgata ggaattaata gcatcggctc aaattccttg gctacagcca
    11041 agtatatgaa aaacaaacct accagaagca ttaccacatg tcctaccgtt gcattggcaa
    11101 aacctgtata agtccagaag tcggcaaggt tgtttcctaa aaatgtgata aattctccca
    11161 tattattcaa taattacgag gtcagtacct tcgagaacag agtccccttt gtttacattg
    11221 atggctgtaa tcttaccgtc tttatcagca ttgatattgt tttccatctt catggcttcc
    11281 aaaatgatga taacttgtcc cttctttact gtatcgccga catttacttt gatatcgagg
    11341 attacaccgg gaagcggaga ttttacacct gacttgccgg tagaagcagc ggccggtttt
    11401 actaccggag tagcaggagc agcaggagcg gatgtggctg ccggacgtgc taccggttta
    11461 acgactacct tcggtgcttt ttccatttca actttgtagg gagtaccgtt cacttctaca
    11521 tgagcgatgt tgtcttcaat atctccaatg gcaactttat atacgttacc gttaatttta
    11581 tatttatatt ctttcatcgt tttattttat tatgggtgac ttactttttg tgaggagtct
    11641 cacgcaacgt ataaatcttt gaactccacg gtgagtaact gcgttttaca cgggtaatgg
    11701 taagtatcgt gtcttccaca tcgtgtacat cgctttggaa ttcgtgcatg gccattgaaa
    11761 tggcagcaaa aacttctccc ggagcctgcc ccagttgttt ctcttttgct tcttgtttat
    11821 cagtaatacc tttagctttc atggcattgc gtttgctgag gttaactgat attttaccta
    11881 taatcttgaa ggagatgtag agtaatatca gcccgcagaa tacaacgctc atggcagaaa
    11941 tagccatacc gatacctacg ctgtcatgct cttcgaattt ttccattttg gcattgctgt
    12001 cgatagtctt gttgttggta ctcggagtga catatttatc ttcgcttcca ccctttactt
    12061 cccattggtc ggctgcatca ctgacacggg cataggattg gttggctttt aaagtaccgg
    12121 caggcactat gacttgatca agcaatttct tgccggaatc atacaaccca atccagttgg
    12181 catttgtggc atccagtttg aagttcgtat gaaatgtacc gcgtcttggt tctccatcag
    12241 cccagaaaag tgcatgctga cgtggtttta tgagtgtcag aacgtcacct ttgggaatga
    12301 aataactggc agtatcaccc ggctggctgc tgaatttcag atagcaacct gcaaggtcgg
    12361 cgctgccgta tgatctgttg aatatttcaa tccatgcgct gtgcacaccg tagtcatcct
    12421 gatagttgct ttcgttgttg accagcactt cattcagcag cagtttgttg ttcgatttct
    12481 gttctttgca agaagagcaa aagcccaaca ccagcatcaa tgaaaggaat attccgattt
    12541 ttgttttatt cataatcgtt cttgttttag tgtgaaaagc ttgattacaa gggaatatta
    12601 ccatgcttct tagccgggtt agtcaatttc ttggtttgca actgttgcag ggcacgaatg
    12661 atgcggaaac gtgtgttacg cggttcgata acatcatcaa tgtagccata tttagctgca
    12721 ttataaggat tggcaaacaa cttggtgtat tcagcctctt tttcagccag gaattgagcc
    12781 ggattttcct gctctttggc ttcgcgggca tataatactt ctacagcacc tgcaccaccc
    12841 attacagcga tttcagcagt aggccaagca taattcatgt cgccacgcag ctgcttacag
    12901 ctcatcacga tgtgcgaacc accgtaggat ttacgcagtg tgatggtaac cttgggtaca
    12961 gtagcttcac cgtatgcata cagcagtttg gcaccgtgca ggatgacgcc gttgtactcc
    13021 tggccggttc ccggaaggaa tcccggtacg tctaccaatg atacgatagg aatattgaag
    13081 gcgtcgcaga aacggacgaa gcgtgcgccc ttgcgggatg cgttgctgtc gagcacacct
    13141 gccagatact tcggctggtt ggcaacaata cctacggact gtccgttgaa acgtgcgaaa
    13201 ccaataatga tattctttga ataatctttt tggatttcga ggaactcacc attatctatg
    13261 atagcaccaa ttacctcgta catatcgtac ggcttgttcg ggttatcagg aatgatgtcg
    13321 ttcagggaat cttccagacg gtcgataggg tctgtacagt ctacataggg agcttcttcc
    13381 aggttgttct ggggaatgta gctcaacagt ttgcggataa gagccaaacc ttcttcttct
    13441 gtctgtgcag tgaaatgagt aacacctgat ttggtggagt gaacgctcgc gccacccagg
    13501 ttttcctggc ttacgtcttc tccggttaca gtctttacta ccttcggacc ggtaaggaac
    13561 atgtaggatg taccttccat catcaaagta aagtctgtca aggcaggaga gtaaacggcg
    13621 ccaccggcac aaggaccgaa aataccggaa atctgcggaa tgacacccga agcaagtatg
    13681 ttacgttgga agatttcagc gtagccagcc aaggcattaa taccttcctg aatacgtgca
    13741 ccgcccgagt cgttgatacc gatacacgga gcacccattt tcatggcttg gtccataatc
    13801 ttacagattt tcagagacat ggtttcggac agtgaaccgg cagaaactgt gaagtcctgt
    13861 gcgaagatat aaaccagacg gccttcgatt gtaccgcaac cggttactac accgtcaccg
    13921 gggtagtgtt tcttttccat gccgaagttc gtacatctat gttctacgaa catgtccatt
    13981 tcttcgaaac tgccttcgtc aagaagcatg gctatacgct cacgagctgt atatttaccc
    14041 ttctcgtgtt gctttgcaat cgctttttca ccaccaccga gacgtgctgc agcgcggcgg
    14101 tctataagct ctttaatctt ttcaagttga ttactcatga atttatattc tttaagtgtt
    14161 tatacaattt atgatttgat gattttaaag tcttgcttat tccggtttct cgcaaagctc
    14221 ggtcaggaca ccgagagttg acttcggatg caggaatgca atgttcagac cttctgcacc
    14281 tttgcgggga gctttgtcta taaggcggat acctttttct tcgacttcgg caagcgcacc
    14341 ggccactccg tcttcaacgg cgaatgcgag atgatgcatg ccaccgttac cgttgttctt
    14401 ttcgatgaac ttggcaattg tgctttcggg agaagtaggt tccaacaatt cgatctttac
    14461 atcgcccact ttcaggaaag cggttctaac tttctgatct tccacggttt cgatgttgta
    14521 gcatttcaaa cctaaaacgt tttcgtagta cggaagggct tcttcaatgc tcttaacggc
    14581 aatgcccaga tgctcaatgt gtgaaatctt cataactata taaattaatg ttagtattgt
    14641 atccttttta ataaaggtat aaagcagcac aaagaaagag aattcttcct taataaagaa
    14701 atttttcatc aattaattca tggataattg aactttagaa ggattttttc agactttaga
    14761 tagagaccgg ttgttttcct gatatcgtcc gctaacggac atccccactg tccgaaaatg
    14821 aacacttacc cctctatgaa atcttcccgg ccacttggca cactctttgc ttttctgttt
    14881 gcgacaattt taaagattga acatgaaaaa gaatatttta cttgcagttt gttttttgat
    14941 gccgttggca accatggcgc agaatgatac tttgggacat gaacgcaata ttacgctgtc
    15001 ggaggccatt gtactggccc gtacgcagtc tgtggatgct gctgtggcat tgaatgaatt
    15061 gaaaaccgcg tattgggaat accgtacatt ccgtgcggac ttgttgccgg aagtgaattt
    15121 caccggtaca ctacccaact ataacaagtc ctacagtacc taccagaatt ccgacggctc
    15181 ctatagcttt gtccgcaaca atacactggg gctgtccggc cagctttcgg tagaccagaa
    15241 catttggttt acggggggta agctgtcact gacttcttcg ctggattatc tcaaacaact
    15301 gggttccgga ggagcgaagc agttcatgtc agtccccgtg agcctggagt tgacgcagcc
    15361 ggtcttcgga gtgaatacct tgaagtggaa ccgccgtata gagcccgtac gctatgctga
    15421 ggcaaaggcc gagttcattt cagctacgga agaggtgacg atgaaaacca tcacttattt
    15481 ctttgagttg ctgctggcca aagaatcgct cgctaccgcc atgcagaaca agacgaatgc
    15541 cgaccgcctt tatgaagtgg ccatagccaa acgtaaaatg ggacagatat ccgagaatga
    15601 tttgttgcag cttaaactga attcattgca gggcaaggcc gacgtgactg aggcagagag
    15661 caacctgaat gcaaaaatgt tccagctccg ttctttcctc ggggtgtccg agcaggaaag
    15721 cctgaatccg gtgttgcccg ccactgttcc cgatataaag atggagtatg accgtgtgct
    15781 gaacaaggca ctggaacgca actcctttgc acagaacatt cgccgccgcc agctcgaagc
    15841 tgattatgaa gtggcaacgg cacgcggaaa cttgcgcagc atcgacctct ttgccagtgt
    15901 gggctatacg gggcagaacc atgaattctc ttcagcctac cgggacttgc ttgataatca
    15961 gattgtgcag gtaggcgtca agattcctat ccttgactgg ggcaagcgcc gcggcaaggt
    16021 aagggtggca aagagcaacc gtgaagtggt cttgtccaga atccgtcagg aacagatgga
    16081 ctttaatcag gacatctttt tgctggtggc taacttcaac aaccaggcgc aacagctgga
    16141 catagccgaa gaggcggatg tcattgctga gaagcgttac aagaccagtg tagagacctt
    16201 tatgataggt aaaatcagca ccctggacct gaacgatgca cagaactcta aagacgaagc
    16261 ccgtcaaaag catatttcag agctgtacta ctattggtat tacttctatc agctccgcag
    16321 cttgaccctt tgggattttg aacgcgatac ggaattggaa gctgattttg aagaggtggt
    16381 aagaggataa gtcgacgggt tgcaagtgat aagttatgaa ttatttgccg gtaaaagtac
    16441 cgtatatgcg atattatagg taaataactt ataacttatc attcataact ctgctttttt
    16501 acttattttt gcgggaaaca aactacaatt tttatgatac tgataataga c
//
