LOCUS       gnlProkkaADNBDKCI_77    7633 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ADNBDKCI_77.
ACCESSION   gnlProkkaADNBDKCI_77
VERSION     gnlProkkaADNBDKCI_77
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 14:52:24
            Original ID  :: gnl|Prokka|ADNBDKCI_77
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 7633
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..7633
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[263:5225]"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      264..5225
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    1..7633
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..7633
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX))"
                     /tool="antismash"
     CDS             264..5225
                     /NRPS_PKS="Domain: PCP (172-237). E-value: 3.1e-14. Score:
                     44.8. Matches aSDomain: nrpspksdomains_ctg77_1_PCP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (355-636). E-value:
                     8.1e-35. Score: 112.1. Matches aSDomain:
                     nrpspksdomains_ctg77_1_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (809-1228). E-value:
                     4.3e-97. Score: 317.1. Matches aSDomain:
                     nrpspksdomains_ctg77_1_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (1339-1402). E-value: 3.6e-19.
                     Score: 60.6. Matches aSDomain:
                     nrpspksdomains_ctg77_1_PCP.2"
                     /NRPS_PKS="Domain: Thioesterase (1425-1640). E-value:
                     4.9e-22. Score: 71.3. Matches aSDomain:
                     nrpspksdomains_ctg77_1_Thioesterase.1"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     129.2; E-value: 4.1e-39)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg77_1"
                     /sec_met_domain="PP-binding (E-value: 7.2e-13, bitscore:
                     36.7, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 7e-42, bitscore:
                     131.1, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 6.9e-112, bitscore:
                     361.6, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGYYNDIQSTDEVLKDGWLSTGDLGFFDYNNILYIVGRKKETII
                     VNGQNFHPFDLENCVLEKFGLSIEKTVFTSFYSSTENREIVLHFFVLSRKMSEEQIRQL
                     INECNAFLADKVGFAPEYSIKIKKGEILRTSSSKIKRRSMAKYFEQGQYNKSIVKLNKE
                     SHNMDYLLVLKKIWSEVLKTNLIHIEDNFFSLGGDSIRSMMAVSKLEELLNIKLENSFF
                     YKYPTLVSQKHYLEQYLLKELQSPLNEYELLVREFISEEIGIPSLEIQYTENIITKVTS
                     FAAVYQMMKRLTEVFDKITLDDIKDKTCIRDIAQTIKERYVTPEGYSFPLMDFQETLFY
                     HSKSFIRNEPTGLSCYIICRTQLKGFFDPACWDKTLNHIINCHPLLHSILSEESDKPEM
                     ITLPEYPTFKSSYEDITSMNKEQQETFFLQKDEKDHDHRFDLKEYPLFYCNIYKTGEDE
                     HELIIHIDHQIIDGFSFFQFLQELTSTYDQFIAGKEITVEQEKGLTFSDYVFVERFRRQ
                     TKRYQNAMDFALKVFKDLPEKISIPTKCQPSLINKVHFNTLHTELDSLLMNKVLEISSH
                     TSGICLNSLLMACYFKLMNLWSGQNDLIINMPVFNREQHLPNAKNIIGSFLDIFPVRIQ
                     TSPQEPIVSIARKIEQFVRTMLEYPISSIELSRKIAEQEGLKQSSLSAIIFSNSINMLP
                     KGISHSSRYLTIGAPKVQTGAPGTYIDLVMYTWENKWCFDWNYVRELFDAEYIQLLSEQ
                     FTSMLNQLVDDTNTKGYEERSCSNILPLFYIKLLEQTNKTEHAYPLKTIYEQISNTVDL
                     YPNREAISYQGVSLTYTEFWKKANQMAHFLRSLGVVRNSKVALLLNRTLDLPIVQLGIL
                     LAGGAYVPIDPSYPSDRIQYMINDCGAEVLVTQGIHVDNINSSYTPNIKHCVLLDDDSI
                     PLPDTYRRYTVNDINSQSMDNIVPCNTPDDLIYMIYTSGSTGQPKGTMLRHRNVSNFLN
                     YEKEAFNVNCNNRFALITSYSFDMTVTSNWLPFIAGASLHILSDNATKDIEKLLYFIDE
                     EKINFLNVTPSHFSMLVNMLGFLERPVNLSPNMTIMLGAEIINVSDINRWLENYPLHKF
                     INEYGPTETTVASTFYPIPIEEDGKCHLNIVPIGKPIYNTQVYVLNDNLEYTLPEVPGI
                     LYIGGEGVSCGYLNKEEKTKSVFINNPITHEGIVYNTGDVVKMTVTGDIVFVGRKDFQV
                     NVRGYRIELGEIENALLKVSGITEACAEIQYDVNKQPVVVAFYVTANNCDLEYKDIMSV
                     LQMKIPHYMLPSAMARIEQIPISANGKTDKKQLPNIANQKQNFVKRDIVGPRNEREKQI
                     TLIWEKVLGIPEVGVFDNFWDIGGDSIRSVRLIKELKEVGLTNIKLKDLFDKPTIAELL
                     EQEIENNKVENLICMKKVSTPYAKLICLPYAAGTPGMYSTFSGDFTGEINLYTVQYPGH
                     GDGREIKSSVEEVGALLANELKEADKEIPLFIMGYSYSCYIAYDICKRFEQENIPIQGI
                     IMIGGTPPTLRDDLMQFFSNDDNALLDYSRAKDLLNEELIATLSDEEKHEYLHELRMNT
                     VAMVNYKFLDCKLKTPLCSIVGREDEPTIRNNQHLWNNYFQKVSFHQLPGGHVLITKYH
                     AELAKLIMNYIELHV"
     CDS_motif       372..434
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg77_1_0001"
                     /evalue="1.30E-02"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg77_1"
                     /protein_end="57"
                     /protein_start="36"
                     /score="8.5"
                     /tool="antismash"
                     /translation="VGRKKETIIVNGQNFHPFDLE"
     aSDomain        780..974
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg77_1_PCP.1"
                     /evalue="3.10E-14"
                     /label="ctg77_1_PCP.1"
                     /locus_tag="ctg77_1"
                     /protein_end="237"
                     /protein_start="172"
                     /score="44.8"
                     /tool="antismash"
                     /translation="LKKIWSEVLKTNLIHIEDNFFSLGGDSIRSMMAVSKLEELLNIKL
                     ENSFFYKYPTLVSQKHYLEQ"
     CDS_motif       834..863
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg77_1_0002"
                     /evalue="2.20E-02"
                     /label="PCP_mC"
                     /locus_tag="ctg77_1"
                     /protein_end="200"
                     /protein_start="190"
                     /score="8.4"
                     /tool="antismash"
                     /translation="NFFSLGGDSI"
     aSDomain        1329..2171
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg77_1_Condensation_LCL.1"
                     /domain_subtypes="Condensation_LCL"
                     /evalue="8.10E-35"
                     /label="ctg77_1_Condensation_LCL.1"
                     /locus_tag="ctg77_1"
                     /protein_end="636"
                     /protein_start="355"
                     /score="112.1"
                     /tool="antismash"
                     /translation="YIICRTQLKGFFDPACWDKTLNHIINCHPLLHSILSEESDKPEMI
                     TLPEYPTFKSSYEDITSMNKEQQETFFLQKDEKDHDHRFDLKEYPLFYCNIYKTGEDEH
                     ELIIHIDHQIIDGFSFFQFLQELTSTYDQFIAGKEITVEQEKGLTFSDYVFVERFRRQT
                     KRYQNAMDFALKVFKDLPEKISIPTKCQPSLINKVHFNTLHTELDSLLMNKVLEISSHT
                     SGICLNSLLMACYFKLMNLWSGQNDLIINMPVFNREQHLPNAKNIIGSFLDIFPVRIQT
                     "
     aSModule        1329..5183
                     /complete
                     /domains="nrpspksdomains_ctg77_1_Condensation_LCL.1"
                     /domains="nrpspksdomains_ctg77_1_AMP-binding.1"
                     /domains="nrpspksdomains_ctg77_1_PCP.2"
                     /domains="nrpspksdomains_ctg77_1_Thioesterase.1"
                     /final_module
                     /locus_tags="ctg77_1"
                     /monomer_pairings="X -> X"
                     /tool="antismash"
                     /type="nrps"
     aSDomain        2691..3947
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg77_1_AMP-binding.1"
                     /evalue="4.30E-97"
                     /label="ctg77_1_AMP-binding.1"
                     /locus_tag="ctg77_1"
                     /protein_end="1228"
                     /protein_start="809"
                     /score="317.1"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="VDLYPNREAISYQGVSLTYTEFWKKANQMAHFLRSLGVVRNSKVA
                     LLLNRTLDLPIVQLGILLAGGAYVPIDPSYPSDRIQYMINDCGAEVLVTQGIHVDNINS
                     SYTPNIKHCVLLDDDSIPLPDTYRRYTVNDINSQSMDNIVPCNTPDDLIYMIYTSGSTG
                     QPKGTMLRHRNVSNFLNYEKEAFNVNCNNRFALITSYSFDMTVTSNWLPFIAGASLHIL
                     SDNATKDIEKLLYFIDEEKINFLNVTPSHFSMLVNMLGFLERPVNLSPNMTIMLGAEII
                     NVSDINRWLENYPLHKFINEYGPTETTVASTFYPIPIEEDGKCHLNIVPIGKPIYNTQV
                     YVLNDNLEYTLPEVPGILYIGGEGVSCGYLNKEEKTKSVFINNPITHEGIVYNTGDVVK
                     MTVTGDIVFVGRKDFQVNVR"
     CDS_motif       2865..2906
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg77_1_0003"
                     /evalue="1.30E-04"
                     /label="NRPS-A_a2"
                     /locus_tag="ctg77_1"
                     /protein_end="881"
                     /protein_start="867"
                     /score="15.3"
                     /tool="antismash"
                     /translation="LGILLAGGAYVPID"
     CDS_motif       3150..3206
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg77_1_0004"
                     /evalue="1.50E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg77_1"
                     /protein_end="981"
                     /protein_start="962"
                     /score="26.8"
                     /tool="antismash"
                     /translation="YMIYTSGSTGQPKGTMLRH"
     CDS_motif       3747..3830
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg77_1_0005"
                     /evalue="5.00E-09"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg77_1"
                     /protein_end="1189"
                     /protein_start="1161"
                     /score="28.5"
                     /tool="antismash"
                     /translation="EVPGILYIGGEGVSCGYLNKEEKTKSVF"
     CDS_motif       3912..3977
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg77_1_0006"
                     /evalue="2.50E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg77_1"
                     /protein_end="1238"
                     /protein_start="1216"
                     /score="35.5"
                     /tool="antismash"
                     /translation="FVGRKDFQVNVRGYRIELGEIE"
     aSDomain        4281..4469
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg77_1_PCP.2"
                     /evalue="3.60E-19"
                     /label="ctg77_1_PCP.2"
                     /locus_tag="ctg77_1"
                     /protein_end="1402"
                     /protein_start="1339"
                     /score="60.6"
                     /tool="antismash"
                     /translation="EKQITLIWEKVLGIPEVGVFDNFWDIGGDSIRSVRLIKELKEVGL
                     TNIKLKDLFDKPTIAELL"
     CDS_motif       4344..4373
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg77_1_0007"
                     /evalue="1.50E+00"
                     /label="PCP_mE"
                     /locus_tag="ctg77_1"
                     /protein_end="1370"
                     /protein_start="1360"
                     /score="2.9"
                     /tool="antismash"
                     /translation="NFWDIGGDSI"
     aSDomain        4539..5183
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg77_1_Thioesterase.1"
                     /evalue="4.90E-22"
                     /label="ctg77_1_Thioesterase.1"
                     /locus_tag="ctg77_1"
                     /protein_end="1640"
                     /protein_start="1425"
                     /score="71.3"
                     /tool="antismash"
                     /translation="KLICLPYAAGTPGMYSTFSGDFTGEINLYTVQYPGHGDGREIKSS
                     VEEVGALLANELKEADKEIPLFIMGYSYSCYIAYDICKRFEQENIPIQGIIMIGGTPPT
                     LRDDLMQFFSNDDNALLDYSRAKDLLNEELIATLSDEEKHEYLHELRMNTVAMVNYKFL
                     DCKLKTPLCSIVGREDEPTIRNNQHLWNNYFQKVSFHQLPGGHVLITKYHAE"
     CDS_motif       5130..5156
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg77_1_0008"
                     /evalue="4.40E+00"
                     /label="PCP_mC"
                     /locus_tag="ctg77_1"
                     /protein_end="1631"
                     /protein_start="1622"
                     /score="1.7"
                     /tool="antismash"
                     /translation="SFHQLPGGH"
     CDS             5228..5818
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1060:4'-phosphopantetheinyl transferase (Score: 138.8;
                     E-value: 2.9e-42)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg77_2"
                     /transl_table=11
                     /translation="MLVLPFSDIAVEIVEDSPFATSDNLFNEEKIFIKREWSEIRLKTY
                     ILGRCAAHRALQTLQKEIVPILKGRDGEPIWPFDIVGSISHKDAIAVAAVGKKKRYKGI
                     GVDIEDQTTILSKKEYSLFCTPQEIACIDKKEFSPIDIFSRKEAILKAYYTAYSKLCNW
                     IDIDTINVSKASNVTIICMLKKNFIINLCCVEK"
     CDS             5767..7560
                     /gene_functions="transport (smcogs)
                     SMCOG1082:TonB-dependent siderophore receptor family
                     (Score: 103.3; E-value: 3e-31)"
                     /gene_kind="transport"
                     /locus_tag="ctg77_3"
                     /transl_table=11
                     /translation="MHVKKKFYYKPMLCRKVKTILVIMGICCFPMISWAQVFLSGRIVD
                     KKTNEPVVGASVYIRKNQVGDNANDNGLYRIKLPQNGTYLVEVSFIGYKTIKQSVTVNR
                     NTTKNFFLEESTEVLNEVVVKASSQQAEINHIRKSPMAVTVVDGAKLRGRSTGIEEVLT
                     RTSGIKVRKSGGLGSSSKMSIHGLEGKRVAIYIDGFPLNSPDGSFDINDIPIDAIKYIE
                     IYKGIVPAEYGSDGLGGAINVVTREDECDLVGFTQEFASFGTSKTLVSVKKMFEKPGIQ
                     IGGGFFHNKSDNNYKMTYPVFETNLPSSAYQEVIRNNDYYRSTMYNVGLTFTKFWFDKI
                     ELECAFYNNKKGIQALDFDSRFSHTHGTNIMPTLTLEKKNFLFKNLEFKSGLVTPIIHT
                     HLVDTARTKRQWDGTITNTMGETDDNLLNYSDDKQFEIRHKLNLKYKLKQHTFNLNNQF
                     TYSRYRPKDDYTAEYVGFDPSGFPSNMKGNTLGLAHEYSSRNNKLQNSLMFSLYYLNSG
                     IYRTSDKIVDESESVKKEPKKTKINNFYYGISEGISYEFFKGVRGKFSLSHNVRLPDTE
                     ELFGDGVTVKPSVDLNPEISN"
ORIGIN
        1 ttagcgatta ctaatttaca aagaaaattc gacaaactgt tatttttcta tctatttatt
       61 tgggtgggaa actttagaat ataagaataa atagagaggc gttctatgaa gggattatca
      121 aattagtcga taaacaacaa gatttttgtg aatttgttag tgcaggtaga atattaccag
      181 gcttacaagt acgcattgtt aaagacggta ttcctcaaaa taatttaaat ttaggagaga
      241 ttcaagtaaa aggcgcttgt gtcatgtctg gttattataa tgacatacaa tcaacagatg
      301 aagtattaaa agacggttgg ttaagtacag gagatttggg cttttttgat tataacaata
      361 ttctttatat agtaggtcga aaaaaggaaa caattatagt aaatggacaa aactttcatc
      421 cttttgattt agaaaattgt gtcttagaga aatttggtct ttcaattgaa aaaactgtat
      481 ttacatcttt ttattcttct acagaaaatc gtgaaattgt acttcatttc tttgtgttat
      541 caagaaaaat gtcggaagaa caaataagac aattaataaa tgaatgtaac gcatttctag
      601 cagacaaagt tggatttgct ccagaatact ctataaagat aaaaaaagga gaaatactca
      661 gaacttctag ctctaaaata aaacgtcgat ctatggcaaa gtattttgag caaggacagt
      721 ataataaatc aattgtaaaa ctaaacaaag aatctcataa tatggattat ttattggttc
      781 tcaaaaaaat atggtcagaa gttttaaaaa caaacctcat tcatatagaa gataacttct
      841 tttctttagg aggagactca atacgcagta tgatggctgt ttctaaactt gaagaactgt
      901 taaatattaa attagaaaat agtttcttct ataaatatcc gaccttagtc tctcaaaaac
      961 attatcttga acaatattta ttaaaagaac ttcaatctcc tttaaatgaa tatgaactgt
     1021 tagttcgaga gtttatcagc gaagaaatag gaattccctc tttagaaata caatatacag
     1081 aaaatattat aactaaagtg acttcttttg ccgctgtata tcaaatgatg aagcgcttaa
     1141 ctgaagtttt tgataaaata acattagatg atataaaaga taaaacttgt atacgagata
     1201 tagcacaaac cattaaggaa cgctatgtaa ctccagaggg gtattctttt ccgttaatgg
     1261 atttccaaga aacattattc tatcacagta aaagttttat ccgtaatgaa ccgacaggat
     1321 taagttgtta tatcatttgt cggacacaat tgaaaggttt ttttgatcca gcatgttggg
     1381 acaagacgtt aaatcacatt attaactgtc atccattgtt acattctatt ctttccgaag
     1441 agtcggataa acctgagatg ataactcttc ctgaatatcc gacatttaaa agttcttatg
     1501 aagatataac ttcaatgaac aaagaacaac aggaaacatt ctttttacaa aaggacgaaa
     1561 aagatcatga tcacagattt gaccttaaag agtatccttt attctattgt aatatttata
     1621 aaacagggga agatgaacat gaattaatta tacatattga tcaccagata attgatggtt
     1681 tcagcttttt tcaattcctt caagaattaa catcaactta tgatcagttt atcgctggta
     1741 aagaaataac tgttgaacaa gaaaaaggtc taactttttc tgactatgtt tttgtggaga
     1801 gattcagaag gcaaacaaag cgatatcaga atgcaatgga ttttgcccta aaggtgttta
     1861 aagatttacc agagaaaata tctattccca cgaaatgtca gccatcttta ataaataaag
     1921 tccattttaa taccttacat acggaattgg attctttatt gatgaataaa gttcttgaaa
     1981 tcagttctca tacttctggt atatgcctta attccttact tatggcatgc tattttaaac
     2041 tgatgaattt gtggtctgga caaaatgatc tcattatcaa catgcctgta tttaacaggg
     2101 aacagcattt acctaatgca aaaaatataa taggtagttt tcttgatatt ttccctgtcc
     2161 gtatccaaac atctccacaa gaaccgattg tttctattgc acgtaagata gaacaatttg
     2221 tacgaaccat gcttgagtat ccaatatctt caatagaatt gtccagaaaa atcgcagaac
     2281 aggaaggctt aaaacaaagc tctttgagtg caattatttt tagtaattct atcaatatgc
     2341 ttcccaaagg tatcagtcat tcatctagat atttgacaat tggtgcgcct aaagtacaga
     2401 caggtgcacc tggtacttat atagaccttg ttatgtatac atgggaaaat aaatggtgtt
     2461 ttgattggaa ttatgttcgt gagctatttg atgcggaata catacaacta ctttctgaac
     2521 aattcacgtc tatgcttaac caattggtag atgatacaaa cactaaggga tacgaagagc
     2581 gttcatgttc aaatatactc cctctcttct atataaaatt attggagcaa acaaataaaa
     2641 cagaacatgc ttatcctctt aaaacaatat atgaacagat cagtaatact gtagatttgt
     2701 atcctaatag agaggcgatc tcttatcaag gagtttcttt aacttataca gagttttgga
     2761 aaaaagctaa tcagatggcg catttcttac gttctcttgg agtggtacga aattctaagg
     2821 ttgctttatt actgaacaga acgcttgatt tgcctatagt acaacttgga attcttttag
     2881 caggtggggc gtatgtgcca attgaccctt cttatccttc ggatagaata cagtatatga
     2941 taaatgactg tggagcagaa gttcttgtaa ctcaaggaat acatgtagac aatattaata
     3001 gttcatatac ccccaacatt aaacattgtg tgttacttga tgatgattct attcctttac
     3061 ctgatacata tcgtcgatac accgtaaatg atataaatag tcaatctatg gataatatag
     3121 taccttgtaa tactcctgat gatttgattt atatgattta tacttctggt tcaacaggac
     3181 aacctaaagg tacaatgctt aggcatagaa atgtatccaa ttttttgaat tatgagaaag
     3241 aagcgtttaa tgtaaactgt aataacaggt ttgctttaat aacatcgtat tcctttgata
     3301 tgactgttac ttctaattgg ctacctttca ttgccggagc ttctttacac attctttccg
     3361 ataatgcaac taaagatata gagaaacttc tgtattttat agatgaagaa aaaatcaatt
     3421 ttttgaatgt aactccctct catttttcaa tgttggtaaa tatgttggga tttttggaga
     3481 gacctgtaaa cctatcaccc aatatgacta ttatgctggg tgctgaaatt atcaatgttt
     3541 cggatataaa caggtggtta gaaaattatc ctttgcacaa atttattaat gaatacggcc
     3601 ctacagaaac aacggtggct tccacttttt atcctatccc gattgaagaa gacggcaaat
     3661 gtcatttaaa tatagttcca atagggaaac cgatttataa tacacaagta tatgtattaa
     3721 atgataattt agaatataca ctaccagaag ttcctggtat cctttatatt ggaggcgagg
     3781 gagtgtcatg tggttatttg aataaagaag agaaaacgaa atctgtattt atcaataatc
     3841 ctattactca tgaaggaatt gtatataata caggagacgt tgtaaagatg actgtaactg
     3901 gcgatattgt atttgtagga cgtaaagatt ttcaagtaaa tgtcagaggg tatagaattg
     3961 aattaggaga aatagagaat gctttattaa aagtatcagg tattacagag gcttgtgcag
     4021 agattcaata tgatgtaaac aaacagcctg tagttgtagc tttttatgtt acagcaaata
     4081 attgtgattt agaatacaag gatataatgt ctgttctgca aatgaagata cctcactata
     4141 tgttaccttc cgcaatggct agaatagagc agattccaat ttctgccaat ggaaaaacag
     4201 acaagaagca attacccaat attgcgaatc agaaacaaaa ttttgttaaa agggatattg
     4261 taggtccaag gaatgaaagg gaaaaacaaa taaccttaat ctgggaaaag gtattaggga
     4321 taccagaggt aggtgtattt gataatttct gggatatagg aggcgactct atccgatctg
     4381 taaggttaat aaaagaatta aaggaggtcg gattaaccaa catcaaatta aaagatttat
     4441 tcgataaacc tacgatagcc gaactgcttg aacaagaaat agagaataat aaagttgaga
     4501 atctcatttg tatgaaaaag gtttctactc catatgcaaa acttatatgt cttccatatg
     4561 cagcaggaac ccctggtatg tatagtacat tttctgggga ttttaccgga gaaatcaact
     4621 tatatacagt acaatatccg ggacatggag atggacgtga gataaagtcc tctgtagaag
     4681 aagttggtgc gctattagcc aatgaactga aagaggctga taaagagatt cctttgttta
     4741 tcatgggata ttcttacagt tgctatattg cttatgatat ctgtaaacga tttgaacaag
     4801 aaaatattcc gatacagggt attataatga ttggtggaac tcctcctaca ttgcgtgatg
     4861 acttaatgca attcttttca aatgacgata atgccctttt ggattattca cgtgcaaaag
     4921 atctgttgaa tgaagaattg atcgcaactt tatcagatga agaaaaacat gaatatttgc
     4981 atgagttgag aatgaatact gtagcaatgg taaattacaa gtttcttgat tgtaaattga
     5041 aaaccccatt atgttccatc gtcggtagag aggatgagcc tacaattcga aacaatcaac
     5101 atctatggaa taattacttt cagaaagttt ctttccacca attgccagga gggcatgttc
     5161 ttattacaaa atatcatgcg gaattagcta agttgataat gaattatata gaattgcatg
     5221 tataaatatg cttgtattac ccttttccga tatagcagta gaaattgtgg aagatagtcc
     5281 ttttgctact tcagataatc tctttaatga ggaaaaaata ttcattaaaa gagaatggtc
     5341 tgaaatacgt cttaaaactt atattttggg acgttgtgcc gcacatcgtg ccttacagac
     5401 tttacaaaag gaaatagttc ccattttaaa aggaagagat ggtgaaccaa tatggccatt
     5461 tgacatagtt ggttctatat ctcataaaga tgcaatagca gttgctgctg ttggaaagaa
     5521 aaagaggtat aagggtattg gagtagatat tgaagatcaa acgacgatat tatcaaaaaa
     5581 ggaatattct cttttttgta caccccaaga gatagcgtgt atagataaga aagaattttc
     5641 tcctattgac attttttcac gtaaagaagc tattctaaag gcatattata cagcatatag
     5701 taaattatgc aattggattg atattgacac gataaatgta tctaaagctt ccaatgtaac
     5761 tataatatgc atgttaaaaa aaaattttat tataaaccta tgttgtgtag aaaagtaaaa
     5821 acaattttag tcattatggg aatatgttgt ttccctatga tatcttgggc acaagttttt
     5881 ctttctggtc gaatcgtaga taaaaagaca aatgaacctg ttgtaggagc ttctgtatat
     5941 atacgaaaaa atcaggttgg agataatgca aatgataatg ggttatacag aataaaatta
     6001 cctcaaaacg gaacgtatct tgtagaggtt tcttttatcg gatacaaaac aataaaacag
     6061 tctgttactg taaatagaaa tacaactaaa aatttctttt tggaagaaag tacagaagtg
     6121 ttgaatgagg tcgtggtaaa agcatcctca cagcaggcag aaataaatca tatacgtaaa
     6181 agtcctatgg ctgtaacggt tgttgatgga gcaaaattaa gaggtcgttc aactggaatt
     6241 gaagaagtac ttactcgtac ttctggaatc aaagttagaa aatccggagg tttgggtagc
     6301 tcttctaaaa tgtccataca tggtctggaa ggaaaaagag tagctattta tatagatggt
     6361 tttcctttaa atagccccga tggttcattt gatataaacg acatacctat tgatgccatt
     6421 aaatatattg agatatataa aggaatagtt cctgctgaat atggcagtga tggtctggga
     6481 ggagcgatta atgttgttac aagagaggac gagtgtgact tggtaggctt tactcaggag
     6541 tttgcttcat ttggtacttc caaaacgtta gtcagtgtaa aaaaaatgtt tgaaaaacca
     6601 gggattcaaa ttggaggagg tttttttcat aataaatcgg ataataatta taaaatgact
     6661 tatcctgttt ttgaaacaaa tttaccttca agtgcctacc aagaagtaat aagaaataat
     6721 gattattata ggtccacaat gtataatgta ggtttaacat ttacaaaatt ctggtttgat
     6781 aagattgaat tagaatgtgc tttttataac aataaaaagg gaattcaggc cttagatttt
     6841 gattcacgtt tttctcatac acatgggaca aacattatgc ctactttaac tttagagaag
     6901 aagaatttct tatttaaaaa ccttgaattc aagtcaggtc tagtaactcc aatcattcat
     6961 acgcatttgg ttgataccgc tagaacaaaa cggcaatggg atggaaccat aacaaataca
     7021 atgggagaaa ctgatgataa tttattaaac tattcagatg acaaacaatt tgaaatcaga
     7081 cataaattga atttaaaata caagttaaag caacatacct ttaatcttaa caatcaattc
     7141 acatattcaa ggtatagacc taaggatgat tatacagcag aatatgttgg ttttgaccct
     7201 agtggttttc ccagtaatat gaagggaaat actttggggt tagcacatga gtattcttca
     7261 cgtaataaca aacttcaaaa ctctttaatg ttcagtctat actatttaaa ttctggaata
     7321 tatagaacaa gtgataaaat tgtagatgaa tctgaaagtg ttaagaaaga accgaaaaaa
     7381 acaaaaataa acaattttta ctatggaata agtgaaggaa tcagttatga atttttcaaa
     7441 ggggtgagag gtaaattttc cttatcacat aacgtgaggc ttcctgatac ggaagaattg
     7501 tttggagacg gagtgacagt aaagccttca gttgatttaa atcccgaaat aagtaactaa
     7561 agtttcccac ccaaataaat agatagaaaa ataacagttt gtcgaatttt ctttgtaaat
     7621 tagtaatcgc taa
//
