LOCUS       c00375_gnlPro..        13664 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EMKGDCOH_375.
ACCESSION   c00375_gnlPro..
VERSION     c00375_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 13:48:55
            Original ID  :: gnl|Prokka|EMKGDCOH_375
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13664
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13664
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[820:3664]"
                     /cutoff="5000"
                     /detection_rule="(Fer4_7 and TPP_enzyme_C and POR and POR_N
                     and PFOR_II and not (EKR or Fer4_16))"
                     /neighbourhood="10000"
                     /product="porA"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      821..3664
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="(Fer4_7 and TPP_enzyme_C and POR and POR_N
                     and PFOR_II and not (EKR or Fer4_16))"
                     /neighbourhood="10000"
                     /product="porA"
                     /protocluster_number="1"
     cand_cluster    1..13664
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Fer4_7 and TPP_enzyme_C and POR and
                     POR_N and PFOR_II and not (EKR or Fer4_16))"
                     /kind="single"
                     /product="porA"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13664
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="porA"
                     /region_number="1"
                     /rules="(Fer4_7 and TPP_enzyme_C and POR and POR_N and
                     PFOR_II and not (EKR or Fer4_16))"
                     /tool="gutsmash"
     CDS             3..353
                     /locus_tag="ctg375_1"
                     /transl_table=11
                     /translation="YKDFGTYSTESCDYPDFAHPLALAVEAGECYPGIAICGSGEGISI
                     TLNKHQGIRAALCWTAEIAHLARQHNDANVLVMPGRFISTEEADMIMREFFSTPFEGGR
                     HQRRVDKIPVHL"
     CDS             529..804
                     /locus_tag="ctg375_2"
                     /transl_table=11
                     /translation="MERLNTIKELINQGNVEQAIQQLDEILQTDFPGKDEAYYLRGNAY
                     RKQGNWQQALNNYQYAIDLNPESPAQHAYQMAMDILNFYNKDMYNQ"
     CDS             821..1048
                     /gene_functions="biosynthetic (rule-based-clusters) porA:
                     Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg375_3"
                     /sec_met_domain="Fer4_7 (E-value: 1.7e-13, bitscore: 41.2,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_2 (E-value: 4e-09, bitscore: 26.5,
                     seeds: 214, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 6.5e-09, bitscore: 25.9,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 1.5e-06, bitscore: 18.8,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKIKGAIVVDTERCKGCNLCVVACPLNVIALTKEVNVKGYNYAH
                     QILEDTCNGCASCATVCPDGCISVYKIKVE"
     CDS             1068..2153
                     /gene_functions="biosynthetic (rule-based-clusters) porA:
                     PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters) porA:
                     POR_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg375_4"
                     /sec_met_domain="PFOR_II (E-value: 6.5e-29, bitscore: 90.5,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 2.3e-49, bitscore: 158.3,
                     seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEEVVLMKGNEAIAHAAIRCGADGYFGYPITPQSEVLETLAELK
                     PWETTGMVVLQAESEVAAINMVYGGAGSGKMVMTSSSSPGVSLKQEGISYLAGAELPCL
                     IVNVMRGGPGLGTIQPSQADYFQTVKGGGHGDYRLIALAPASVQEMADFVGLAFELAFK
                     YRNPAIILADGVIGQMMEKVVLPVQKPRRTDAEVIEQCPWATTGRTNGRKPNVITSLEL
                     KPEEMEKNNIRFQAKYKQIEENEVRFEEIHCDDADYLIVAFGSMARIGQKAMELAREEG
                     IKVGMLRPITLWPFPTKAIAAYADKVKGMLVTELNAGQMVEDVRLAVNGKVKVEHFGRL
                     GGIVPDPDEIVDALKEKLIKK"
     CDS             2150..2323
                     /locus_tag="ctg375_5"
                     /transl_table=11
                     /translation="MNPDKIRNVLNILFMVLALAAIIIYFAAKDDFKLFIYVCGAAIFV
                     KLMEFFIRFTNR"
     CDS             2335..3096
                     /gene_functions="biosynthetic (rule-based-clusters) porA:
                     TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg375_6"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.3e-26, bitscore:
                     83.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKEDIIKPENLVAKKPTLMNDNPMHYCPGCSHGVVHKLVAEVIE
                     EMGLEDKAIGISPVGCAVFIYNYIDIDWQEAAHGRAPALATAIKRLWPDRLVFTYQGDG
                     DLACIGTAETIHALNRGENITIIFINNAIYGMTGGQMAPTTLVGMKTSTSPYGRDVHLH
                     GYPLKMADIAAQLEGTAYVTRQSVQSVPAIRKAKKAIRKAFENSMAGKGSNLVEIVSTC
                     NSGWKMSPAKSNEWMVENMFPFYPLGDLKDK"
     CDS             3119..3664
                     /gene_functions="biosynthetic (rule-based-clusters) porA:
                     POR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg375_7"
                     /sec_met_domain="POR (E-value: 1.3e-36, bitscore: 116.4,
                     seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEEIIIAGFGGQGVLSMGKILAYSGLMEGKEVTWMPAYGPEQRG
                     GTANVTVIVSDEKISSPILSKYDAAIILNQPSLEKFESKVKPGGVLIYDGYGIINSPTR
                     KDIHVYRINAMDAANEMNNAKAFNMIVLGGLLKIKPMVTLDSVLRGLKKTLPERHHHLI
                     PMNEEAIKKGMELIQEMK"
     CDS             3919..6129
                     /locus_tag="ctg375_8"
                     /transl_table=11
                     /translation="MRRIVLTYIFLSVIGIWGAMAQNTLNPMNNRDRFGNQIDPNTQPD
                     NLEDSTNTEIQSLPPKLYMWKLSETLGNRTIIPADTASLNFQSTNLVEGMFGHYNYLGN
                     LGSPRLSRLFFEREESEPTIFMAPFSSFFTRPDQVLFTNSNVPYTNLTYYKAGSKVNGE
                     ERFKSYFSVNVNKQLAFGFNIDYLYGRGYYQNQSTSHFNAGLFGSYIGEKYQVQAVYNN
                     FFLKMNENGGIADDQYITRPENMSGGKKEYESTTIPVKLEQSSNRNKDFYIYLTQRYRL
                     GFTRRVRNTQEGKPTVSAPKASSSPSSEAEISASNNDIALPNDSIASKSVSTLAAANDS
                     LPSVSTADNDSLFEEEFVPVTSFIHTLKVERSRHQFRSGSEPEGFFPEDYKLYKNYSND
                     STTAFSVKNVFGIALLEGFNKYAKAGLTAYISHKFSRYDLMNTDTLTDMRRIRYTEQEI
                     FLGGELAKREGKLLHYNVNGEVGLVDKAIGQFRVNANLDLNFRLWKDTVNFYARGYVSN
                     TLPSFYMRHYHSNHYNWDNDNMDKEFRTRVEGELNISRWGTNLRAGVENIKNYTYFNQS
                     ALPEQNGGNIQVLSATLKQDFRLGVFHLDNEVTWQKTSNETVLPLPQLSLYHNFYILAK
                     LAKKVLTVQLGADVRYFTKYNAPAYAPGVQQFHLQPTDDLVEIGGYPIVNVYANLHLKR
                     TRIFAMMYHVNAGMGSANSFLVPHYPINPRLFKIGVSWNFYD"
     CDS             6141..6971
                     /locus_tag="ctg375_9"
                     /transl_table=11
                     /translation="MTKSRLLKYALLGIAAALIAHYLIKKEEKPKGHPRDYAEIAAEGI
                     IHASTEYNSISFYVDDDTLSGFHYELIEAFARDHGLQAAISPEMSFNKRLEGLADGQYD
                     VIAYGILATSELKDSLLLTTPIVLNKQVLVQRKLENISDSSLFIKSQLDLAGKTLHVVK
                     GSPSILRIRNLGNEIGDTIYVEEIEKYGSEQLIALVAHGDIDYAVCDESIARTAADSIP
                     QIDINTAISFTQFYSWGVSKQSPILLDSLNTWLDSFKKGKEYKKIYKRYYGKRN"
     CDS             complement(7245..9170)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CN_hydrolase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_synthase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg375_10"
                     /sec_met_domain="CN_hydrolase (E-value: 2.3e-20, bitscore:
                     63.1, seeds: 52, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_synthase (E-value: 5.9e-33, bitscore:
                     104.1, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNYGYVKVAAAVPRVKVADCKFNASEIEKEIIIADGKGVQIIAFP
                     ELCITGYTCGDLFAQQLLLEEAEMGLIQILNNTRQMDIISILGMPVALNGVLLNAAVVI
                     QKGRVLGVVPKTYLPNYKEFYEKRWFTSACDVAENSVRLCGQIIPMGRDLLFETADTTF
                     GVEICEDLWAPIPPSSTLALQGAEILFNLSADNEGIGKHNYLRSLISQQSARCIAGYVF
                     SSCGFGESTTDVVFAGNGLIYENGTLLAANERFSFEGQVVISEIDVEHLRTERRVNTTF
                     AACHANCVSALPVRIFTEYVNSRDLNLTRTFEPHPFVPQGIALDERCEEVFSIQVSGLA
                     QRLVHTKAKSAVIGISGGLDSTLALLVCVKTFDKLGWSRQGIVGVTMPGFGTTDRTYTN
                     AIDLMNSLGVTVREVSIKEACIQHFKDIDHDVHVHDVVYENAQARERTQILMDIANQTW
                     GMVIGTGDLSELALGWATYNGDHMSMYGVNASVPKTLVKHLVKWVAEHDMDDASRATLL
                     DIVDTPISPELIPADENGNIQQITEDLVGPYELHDFFLYYFLRCGFRPSKIFFLAARTF
                     KGMYDEETIKKWLQTFCRRFFNQQFKRSCLPDGPKVGSISLSPRGDWRMPSDASSEMWL
                     REVEGL"
     CDS             9468..9902
                     /locus_tag="ctg375_11"
                     /transl_table=11
                     /translation="MDVVKRLQNHNIKPSVQRIAIMNYLIEHRTHPTVDEIYTALSPSI
                     PTLSKTTVYNTLKLLSEQGAAQTLTIDERNTCYDADTSPHGHFLCKRCGKIYDLMCNNN
                     IKKVVDMDMDGHDVQEIHYYYKGICKHCIEEERLRTTKNN"
     CDS             9929..10486
                     /locus_tag="ctg375_12"
                     /transl_table=11
                     /translation="MKKFRCTVCGYVYEGDAAPEKCPLCKAPASKFVEVEEATADGPLV
                     FADEHVIGVAKGCDDEMIKDLNNHFMGECTEVGMYLAMSRQADREGYPEVAEAFKRYAW
                     EEAEHAAKFAELLGDCVWDTKTNLEKRMNAESGACEDKKRIATRAKALNLDAIHDTVHE
                     MAKDEARHGKGFEGLYNRYFKK"
     CDS             10611..11135
                     /locus_tag="ctg375_13"
                     /transl_table=11
                     /translation="MELKEFKITVLPLRAKLLNYARKLTDEPEDAEDAVQEVLLKLWNK
                     RLELEQYRSIEAFAMTLTHNICIDMWRCKRNDTLSLDIVQAASPTGTPERLLEIKDEIR
                     LMHEIIDSLPNLQRTIMRMKDIEGYETDEIAEITGCGPEAIRSNLSRARKKVRDVYLRT
                     IQERKERRNEP"
     CDS             11132..11590
                     /locus_tag="ctg375_14"
                     /transl_table=11
                     /translation="MKIDELLDKYFEGETSCEEERELRRFFTEEEVPEHLQTYRPLFAY
                     LNREATSMAEPTEEKSVTTESAKEVPAQRKPFRLYRTFYAVSGIAAGLLLLLGVAKIIF
                     PLSGVPENYVVIDGQRYTDEKLVEAKALEALQNASFTDEDLSNLLFQH"
     CDS             11603..12073
                     /locus_tag="ctg375_15"
                     /transl_table=11
                     /translation="MKTSILICIRSLCLFSLLICLPAFVHAQERLQIADLFSKYGEQKD
                     VTRVELNGSILKSYRMTTYKSLVFKNVSPYRREIQQAIVHDKQDNAKKAQEVMESGVLR
                     SAYYQLKEVERNGKKLNRYIIFKIGKDSMGTLIYIEGLLSEKEMMDMLYKSE"
     CDS             12094..12999
                     /locus_tag="ctg375_16"
                     /transl_table=11
                     /translation="MKTRIMILACLLAVPAGRMAAQQQTDPEQKATVQTQGDSIIIRKG
                     KGDMRIKVYEEQLEDGEKKEVQIYEGVYLEKVDADKRTFLDALPFIPKKRRYNAYEPHC
                     SGLYIGYSRLANDFLSFGASDKMGLDLSKSWEFGFNILSVYHNFKKNPHWGINLGVSWG
                     YRSFNIDGNYALLKENGTSIFTAGNEDTSYNKSRLRHFFFRVPVLMEWQQRVGRNKVFF
                     NAGPEFEIRHSVKSFSHINGGKKKTVGKGMYVQPVGINLLAQAGYGNIGIYLRYSTYGL
                     FQKDKGPEVSPYSFGVAWYL"
ORIGIN
        1 cttacaagga cttcgggacc tactcaaccg agagttgcga ctatcccgac tttgcacatc
       61 ctttggcact ggccgttgaa gccggagagt gctatccggg aattgccatc tgcggaagcg
      121 gtgaaggtat cagcataacg ctgaacaagc atcagggtat ccgcgcagcc ctctgctgga
      181 cggcagaaat agcccatttg gcacgccagc acaatgatgc caatgtgctt gtcatgccag
      241 ggcgattcat cagtaccgaa gaagccgaca tgattatgag ggaattcttc agtacaccat
      301 tcgaaggcgg acgccaccaa cgaagagtgg acaagatacc ggtacacttg taaagcagta
      361 gaatcacatt ctttatgata tccgcccgaa gctctgacat tctgatagaa tcgtgagaaa
      421 cttcgggctt tttatttgcc cctttttctt atttttcaca gtgaagatgc tcattgtctt
      481 caaataaaaa ctatctttgt ggttcgataa cccggatatt ttttagatat ggaacgactg
      541 aataccataa aagagcttat caaccaggga aatgtagagc aagccatcca gcagcttgac
      601 gaaatactgc aaacagactt tcccggcaaa gacgaagctt actacctgcg gggaaatgcc
      661 tatcggaaac aaggcaactg gcaacaagca ctgaacaact atcagtatgc catcgacctg
      721 aaccccgaaa gcccggcaca acatgcctat caaatggcta tggacatcct gaacttctac
      781 aacaaggata tgtacaatca ataaataaag aacgtaaatt atggcaaaaa tcaaaggagc
      841 aatcgtagta gacaccgaac gttgcaaagg ctgcaacttg tgtgtggtag cgtgtccgct
      901 caacgtaata gccctcacca aggaggtgaa tgtgaaaggg tataactatg cccaccaaat
      961 attggaagat acttgtaacg gctgcgcctc gtgcgccaca gtatgtccgg acggatgtat
     1021 ctcagtatat aaaataaaag tagaataaat ctgtaaatca gtagaatatg gcagaagaag
     1081 ttgtattaat gaaaggaaac gaagccatcg cccacgcagc catccgttgc ggtgcagacg
     1141 gttacttcgg atatcccatt actccgcaat cggaggtatt ggaaactctt gccgaactga
     1201 aaccctggga gacgaccggc atggtggttc ttcaggcaga aagtgaagtg gcagctatca
     1261 atatggtgta cggcggtgcc ggaagtggta aaatggtcat gacctcctcc tccagccccg
     1321 gtgtcagcct aaagcaggaa ggtatctctt atctggcagg tgccgagctg ccttgcttga
     1381 ttgtaaacgt tatgcgcggc ggtcccggtc tgggaaccat ccaaccgagc caggccgact
     1441 atttccagac agtaaaagga ggcggccacg gtgactatcg tctgattgcc cttgctccgg
     1501 cttccgtaca agaaatggca gatttcgtag gactggcatt cgaacttgcc ttcaaatacc
     1561 gtaatccggc aattatcctt gccgacggtg tcatcggcca gatgatggaa aaagtggtgc
     1621 tcccggtaca aaagccacgc cgcaccgatg cggaagtcat cgaacaatgc ccatgggcca
     1681 ctaccggcag aaccaatggc cgcaaaccca acgtcatcac ctcattggaa ctgaaaccgg
     1741 aagaaatgga aaagaacaac atccgtttcc aggccaaata caagcagata gaagagaatg
     1801 aggttcgctt cgaggaaatt cattgcgatg atgccgacta cctgattgta gccttcggct
     1861 ctatggcacg catcggacag aaagcaatgg agctggcacg cgaagaagga atcaaggtag
     1921 gtatgctccg ccccatcacg ttgtggccgt tcccgaccaa agccattgcc gcgtatgccg
     1981 acaaggtgaa aggtatgctc gttacagaat tgaatgccgg acagatggtg gaagatgtcc
     2041 gccttgccgt gaacggtaaa gtgaaagtgg aacatttcgg acgcctcggc ggcattgttc
     2101 ccgatccgga tgagatagta gatgcattga aagaaaaact gattaagaaa tgaatcctga
     2161 taaaataaga aacgtactga acattctctt catggtactt gccttggcag ctatcattat
     2221 atattttgct gcaaaagatg acttcaagct gttcatctac gtctgcggcg cggcgatatt
     2281 cgtcaagttg atggagtttt tcatacggtt caccaacaga taggagaagt gattatgaca
     2341 aaagaagata ttataaagcc cgagaatctg gttgccaaga aaccgactct gatgaacgac
     2401 aatcccatgc actactgccc gggatgcagt cacggcgtag ttcataaact cgtagccgaa
     2461 gttatcgaag aaatgggact ggaagacaaa gcaataggca tctcccccgt gggatgtgcc
     2521 gtgttcatct ataattatat agacatcgac tggcaggaag ccgcccatgg acgtgcgccc
     2581 gcacttgcca ctgccatcaa gcgcctttgg ccagaccgcc tggtgttcac ttaccaagga
     2641 gacggcgacc tggcttgtat cggtactgcc gaaaccatcc acgccttgaa ccgcggcgaa
     2701 aacatcacca tcatcttcat caacaatgcc atctatggta tgaccggggg acaaatggct
     2761 cccactaccc ttgtaggcat gaagacatcg accagccctt acggacgtga cgtgcatctg
     2821 cacggctatc cgctgaagat ggccgatatt gctgcacaat tggaaggaac cgcttacgtg
     2881 acacgccaaa gcgtacagtc cgttcccgcc atccgcaaag cgaaaaaggc tatccgcaaa
     2941 gcattcgaga actctatggc aggcaaaggt tccaaccttg tggaaatcgt ttccacctgt
     3001 aactccggct ggaagatgtc tcctgcgaaa tccaatgaat ggatggtaga gaacatgttc
     3061 cccttctatc cgctgggcga cctgaaagat aaataatcat gctaaagaca gaagaacaat
     3121 gaaagaagaa atcattatag caggcttcgg tggacaaggt gtattgtcca tgggaaagat
     3181 tttggcatat tccggattga tggaaggcaa agaggtgact tggatgccgg cttacggacc
     3241 ggaacaacgt ggtggtacag ccaacgtaac agtcatcgta agtgacgaga aaatatcctc
     3301 acccatctta agcaagtacg atgccgccat catcctgaac cagccgtcat tggagaaatt
     3361 cgaaagcaag gtaaaacccg gaggcgtact tatctacgac ggttacggca tcatcaactc
     3421 gccgacgcgt aaggacatcc acgtttaccg catcaacgcc atggatgccg ccaatgaaat
     3481 gaacaatgcc aaggcgttca acatgattgt attgggtgga ttattgaaaa tcaagccgat
     3541 ggttacactg gacagtgtac tcagaggatt gaagaagaca ctgcccgaac gccaccatca
     3601 cttgataccg atgaacgaag aagctatcaa gaaaggaatg gaacttattc aggaaatgaa
     3661 atgaaaggct gtgtaaagcc actcccccat aagaggagaa actttacgcc agaataagag
     3721 ataaaggaaa gcggataagc ccttgtgata ttgatttatt gcaagggctt atttcatttc
     3781 aagcccccaa agcatggatt caagggcaga gaaccggaag cagtataggg caaaacagaa
     3841 aacaagacat tttaaaagaa gcaaaaaagg ctgaattcag taagcaaata attttttatt
     3901 gtatctttgc gcctaattat gagacgaatt gtactgacat atatatttct gtccgttata
     3961 gggatatggg gggctatggc gcaaaacacc ttaaacccga tgaacaatcg cgaccggttc
     4021 ggtaaccaga ttgacccgaa tacccagccg gacaatctgg aagacagtac caatactgag
     4081 attcaaagtc ttccacccaa gctttacatg tggaaactaa gtgagacact gggcaaccgt
     4141 accatcatac ctgccgacac agccagcctc aacttccaga gcaccaatct ggtggaagga
     4201 atgttcggcc attacaacta cttgggaaat ttaggttctc cacgcctctc acgtctgttc
     4261 ttcgaacggg aggaaagcga acctaccatc ttcatggctc ccttctccag ttttttcaca
     4321 cgtcccgacc aggtgctttt caccaacagc aacgtgcctt acaccaatct tacctactac
     4381 aaagccggca gcaaagtgaa cggtgaagaa cgcttcaagt cctacttctc cgtcaacgtc
     4441 aacaagcagt tggcatttgg ctttaacatc gactatctgt acggacgcgg ttattaccag
     4501 aaccagtcca cctcgcactt caatgcaggt ctgttcggta gctatatcgg cgagaaatat
     4561 caggtacaag cagtctacaa caactttttc ctgaagatga acgagaacgg cggtattgca
     4621 gacgaccaat acatcacccg tcccgaaaac atgtccggag gaaagaaaga gtacgagtcc
     4681 accactatcc cggtcaaatt ggaacagagt tccaaccgta acaaggattt ttatatctat
     4741 ctgacacagc gctatcgtct tggttttacg cggagagtac ggaacacaca agaaggcaaa
     4801 ccgacggtat ccgcacccaa agcctcatcc tccccgtcct ctgaagccga aatatccgct
     4861 tcgaacaacg acatagcatt gccaaacgac agcatagcat caaaatcggt cagcacactt
     4921 gcagctgcca atgacagcct gccgtctgtt tctaccgcag acaacgactc acttttcgaa
     4981 gaagagttcg tccccgtcac cagctttatc cataccttga aagtagagcg gtcgcggcac
     5041 caattccgtt cgggaagcga gcccgaagga ttcttcccgg aagactacaa gctttacaag
     5101 aattacagca acgactccac cacagcattc agtgtaaaga acgtgttcgg aatagccttg
     5161 ctggaaggtt tcaacaaata cgccaaagcc ggacttacgg cttatatctc ccacaagttc
     5221 agccggtacg acctgatgaa tacggacaca cttaccgaca tgcgccgcat ccgctacacc
     5281 gagcaggaaa tcttcctggg tggcgaactc gccaagcgcg aaggcaaact gctgcactac
     5341 aacgtaaacg gtgaagtggg gttggtagac aaagccatcg ggcagttccg cgtcaacgcc
     5401 aatctggacc tgaacttccg tctatggaaa gatacggtga acttctacgc ccgcggttat
     5461 gtgagcaaca cgcttccttc cttctatatg cgccattacc actccaacca ctacaactgg
     5521 gacaacgaca acatggacaa ggaattccgt acgcgtgtgg aaggcgagct gaacatttcc
     5581 cgttggggaa ccaatctccg tgccggcgta gagaatatca agaactacac ctacttcaac
     5641 caaagcgccc tgcccgaaca gaacggaggc aacatacaag tgctgtccgc cacactgaaa
     5701 caagacttcc gcctcggtgt cttccacctg gacaatgagg tgacctggca gaagacgagc
     5761 aatgaaacag tacttccatt gccccaactc tcgctctacc ataacttcta catactggct
     5821 aaactcgcca agaaggtgct gaccgttcag ttgggtgccg atgtccgtta cttcaccaag
     5881 tacaacgcac ctgcctatgc acccggcgtc cagcagttcc atctgcaacc tacggacgat
     5941 ttggtggaaa taggcggtta ccccatcgta aacgtatatg ccaacctgca cttgaagcgg
     6001 acgcgtatct ttgccatgat gtatcacgtc aacgcgggta tgggaagcgc caattccttc
     6061 ctggtgccgc actaccccat caatccgcgc ttgttcaaaa ttggcgtctc atggaatttc
     6121 tatgactaac agatgactgt atgacgaaaa gcagactgct caaatacgca cttctgggaa
     6181 ttgcagcggc tctcattgcc cactatctca tcaagaaaga agagaaaccg aaaggtcatc
     6241 cgcgcgatta tgccgagata gctgccgaag gcatcataca tgcttcgacg gaatacaact
     6301 ccatcagctt ctatgtggat gatgacacct tgtccggttt ccactacgag ctgatagaag
     6361 cttttgcacg cgaccacggg ctgcaagcgg ccatatcacc ggaaatgagc ttcaacaagc
     6421 ggctggaagg cctggccgac gggcaatatg acgtgattgc ctacggcatc ctcgccacca
     6481 gtgagctgaa agactccttg ctgcttacca cccctattgt gctgaacaag caagtgctgg
     6541 tgcaacgcaa gcttgagaat atttccgact cgtcattatt catcaaaagc caactggacc
     6601 tggctggaaa gacactgcac gtagtgaaag gctccccttc catactacgc atccgcaacc
     6661 tgggaaatga gataggcgac accatctacg ttgaggaaat agagaagtac ggttccgaac
     6721 aactgattgc cttggtagcc catggagaca tcgactatgc cgtatgcgac gaaagcattg
     6781 cccgtaccgc agccgacagc attcctcaaa tagacatcaa taccgccatc agcttcacgc
     6841 aattctattc ctggggagta agcaaacagt cccctatcct gctggacagc ctcaacacat
     6901 ggctggatag tttcaaaaag ggaaaagaat acaagaaaat ctacaaacga tactacggga
     6961 aacgaaacta agctgcacta ttccatacac gcagcatatc cctactttta caactagtta
     7021 ttaatcaaca gcttattact gcaaaatcct gcatacattt tgcagtgcca ctgcaaagcc
     7081 gttgcagtgg cactgcacac cgatatgcag tacgactgca acagttatgc agtgatactg
     7141 caacacgttt gcagtcgcac tgcaaaatac atgcagcaag aatgcaaaca agatgcagtc
     7201 atcaaatacc catatcgata ttacggcata cccgaagtaa agaattagag tccttccacc
     7261 tcccttagcc acatctccga cgaagcatcg ctcggcattc tccaatcacc gcgcggactc
     7321 agagagatac tgcccacctt cggaccatcc ggcaaacagg aacgcttgaa ctgctggttg
     7381 aagaaacgac ggcagaaagt ctgcaaccat tttttgatgg tttcttcatc atacatcccc
     7441 ttgaatgtgc gtgctgccag gaaaaatatc ttggaaggac ggaaaccgca gcgcaggaag
     7501 taataaagga agaagtcgtg aagctcatac ggccccacca aatcctcggt aatctgctgg
     7561 atattaccgt tctcatctgc cggaatcagt tccgggctga tgggagtatc cacaatatcg
     7621 agcaaggtag cacgtgaagc atcgtccata tcatgctctg ccacccattt caccaagtgc
     7681 ttcaccagag tcttggggac gctggcattc acaccgtaca tcgacatgtg atcgccgttg
     7741 taagtggccc atcctaaagc aagttccgaa aggtcgcccg taccgataac cattccccag
     7801 gtctggttgg caatatccat caagatttgg gtacgctccc gtgcctgcgc attctcgtaa
     7861 accacgtcgt gcacatggac atcatggtct atgtctttga aatgctgtat gcaggcctcc
     7921 ttgatactga cttcgcggac agtcacaccg agggagttca tcaggtcgat ggcattcgtg
     7981 taagtacggt cggtcgttcc gaatcccggc atggtgacac cgacaatacc ctggcgggac
     8041 catcccaact tatcgaaagt ctttacgcaa accagcagcg ccagcgtaga atccagtcca
     8101 cccgaaatgc cgataacggc acttttcgct ttagtatgca ccagacgttg cgccagtccg
     8161 gacacctgga tggagaatac ctcctcacag cgttcgtcca acgctatccc ctgcggaaca
     8221 aatggatgcg gttcaaaagt acgtgtcagg ttcaaatccc tgctgttgac atactccgta
     8281 aagattcgta ccggaagggc cgaaacacaa tttgcatggc aagccgcgaa ggtcgtattc
     8341 acccggcgct ccgtacgcaa gtgttccaca tcaatttcac tgatgaccac ctgcccttcg
     8401 aaagagaagc gttcgtttgc cgccagcaga gtcccgttct cataaatcag tccgttgccg
     8461 gcaaacacca catccgtagt ggattctccg aaaccgcatg agctgaatac ataaccggca
     8521 atgcaccgtg ccgactgctg gctgataagc gagcgcagat aattgtgctt gccgatacct
     8581 tcattgtcgg ccgaaagatt gaacaagatt tccgcacctt gcagtgccag cgtggaactg
     8641 ggcggtatgg gtgcccacaa atcttcgcat atctccactc cgaaagtggt atctgccgtt
     8701 tcgaacagca ggtctctccc catcggaata atctgcccgc aaaggcgcac actgttttct
     8761 gccacatcac atgcggaagt aaaccagcgc ttctcataaa actccttata attgggaaga
     8821 taagtcttcg ggacaacgcc cagcactctc cccttctgaa tgacaaccgc cgcattcagc
     8881 aacacaccgt tcagtgcaac gggcatgccc aatatcgaaa tgatatccat ctggcgcgta
     8941 ttgttcagaa tctgtatcag ccccatttcc gcctcttcga gcagaagttg ctgggcaaag
     9001 aggtcgccac aagtatatcc ggtaatgcac aactccggaa aagcaatgat ttgcacacct
     9061 ttcccgtcgg ctataataat ctctttttca atctctgagg cattgaactt acagtcagcc
     9121 accttgacac ggggcacagc cgccgctact tttacatatc cgtaattcat aaggatgcta
     9181 tattatttat tcggtgcaaa gatacggcaa aattctgatt aagagagata agagaaaaac
     9241 gttttctcta tatcggcacg agaaaccgac tgaagccggg gtgcatcctg ccttcgcttt
     9301 tatggcaaaa atacggcaac ctgcctacaa gaagaggaac atatataaac aattttaatg
     9361 accgcaacta aaaattttcc aaaaatcttt tggagaatta taggaacttc ctatctttgc
     9421 aagtgaatta aaaatgtaat aattacaagt ttgaaacttt agattatatg gatgtagtaa
     9481 aacgattgca gaatcataat atcaagcctt cagtacagcg catagccatc atgaattact
     9541 tgatagagca tcgtacgcat cccacggtgg atgaaatcta tacggcactg tctccctcca
     9601 taccgacact gtctaaaaca acggtataca ataccttgaa actactgagc gagcaaggtg
     9661 ccgcacaaac cctgactatc gacgagcgta acacatgtta tgatgccgat accagcccgc
     9721 acggtcattt cttgtgcaag cgttgcggaa agatttatga cttgatgtgc aataacaaca
     9781 tcaagaaagt ggtcgacatg gatatggacg ggcacgatgt gcaggaaatc cactactatt
     9841 ataaaggaat ctgtaaacat tgcatagaag aagaacgttt aagaacaaca aagaataact
     9901 aattcaacta attaaaatct gagagaaaat gaaaaaattt agatgtactg tatgcggtta
     9961 cgtatacgaa ggagatgcag ctcccgaaaa gtgcccattg tgtaaagctc ccgcaagcaa
    10021 gttcgtagaa gttgaagaag caacagctga cggcccgctg gtatttgccg acgaacacgt
    10081 aatcggcgta gccaaaggtt gcgacgacga aatgattaaa gacctgaaca accacttcat
    10141 gggcgaatgt acagaagttg gtatgtactt ggcaatgagc cgccaggcag accgtgaagg
    10201 ctatcctgaa gttgcagaag ctttcaagcg ttacgcttgg gaagaagcag aacacgctgc
    10261 taaattcgct gaactgctgg gtgactgcgt atgggacacc aagacaaacc tcgaaaagag
    10321 aatgaacgca gaatcaggtg catgcgaaga caagaagcgt atcgctaccc gtgccaaagc
    10381 attgaacctc gacgctatcc atgacaccgt tcacgaaatg gctaaggacg aagcccgtca
    10441 cggtaaaggt ttcgaaggtc tgtacaaccg ctatttcaag aaataatcct atacttttat
    10501 agtaatgtga agaaaaggga ctgctaatgt tagtaagtcc ctttttttat tccaactttt
    10561 ttcactttac aatgtcacgt ttgtatttcc cattcgtctt atctgtgtaa atggaactca
    10621 aagaattcaa aataaccgtt cttccactcc gtgccaagct gttgaactat gcacggaagt
    10681 tgaccgacga accggaggat gcagaagatg ccgtccagga ggtactgctc aagctatgga
    10741 acaaaaggct tgaactggag caataccgga gcatcgaagc atttgccatg acgttgacgc
    10801 acaacatctg tatagatatg tggcgctgca aacgcaacga caccctatct ctcgacatag
    10861 tgcaggcggc atcccccacc ggaacaccgg aacggctgtt ggaaatcaaa gatgaaatcc
    10921 gtctgatgca cgaaatcatc gactcgctgc ccaatcttca acgcaccatc atgcggatga
    10981 aggacatcga aggatacgaa acggacgaaa tcgccgaaat cacgggatgc ggaccggaag
    11041 ccatccgcag caatctgtca agagcccgga agaaagtgag agacgtttac ctgcgaacca
    11101 tacaagaaag aaaagaaagg agaaatgagc catgaagata gatgaactgc tggataaata
    11161 tttcgaaggg gaaacttcct gcgaagaaga gcgtgaactg cgccgtttct ttaccgaaga
    11221 ggaagtgccg gagcacctgc aaacgtaccg ccccctattc gcttatctga accgggaagc
    11281 aacttcaatg gcagaaccga cagaggaaaa atccgtaaca acagaatcgg caaaggaagt
    11341 acccgcacag cggaagcctt tccgtctcta tcgcacattc tatgctgtca gcggcattgc
    11401 cgccggattg ctcctgcttc tcggggtagc taagattata tttccgcttt ccggtgttcc
    11461 cgaaaattat gtcgtcatcg acggccagcg gtatacagac gagaaactgg tggaagccaa
    11521 agcactagaa gccctgcaga acgccagctt cacggatgaa gatttaagca acttactgtt
    11581 tcaacactaa tataacaagg ttatgaaaac atctatactg atttgcatac gtagtctgtg
    11641 cctcttttcc ctgctgattt gcctgccagc ctttgtacat gcacaagaga gactgcaaat
    11701 agccgaccta ttcagcaagt atggcgagca aaaggacgtg accagggtag aactgaacgg
    11761 cagtatcctg aaatcttacc gcatgactac ctacaagagc cttgtgttca agaatgtatc
    11821 cccctatcgc cgggaaattc agcaggccat tgtacacgac aagcaagata acgcaaagaa
    11881 ggcgcaggag gtaatggaaa gcggtgtgct gcgcagcgct tattaccaac tgaaagaggt
    11941 ggaacgcaat ggaaagaagc tgaaccgcta catcattttc aagataggaa aagactccat
    12001 gggcactttg atttacatag agggtctgct cagtgaaaag gaaatgatgg atatgcttta
    12061 caaatcggaa taacactaaa aacaatatac gatatgaaaa ccagaattat gattttggcc
    12121 tgcctgcttg ctgtaccggc cggccgcatg gcagcacaac aacagactga ccctgaacag
    12181 aaagctacag tacagacaca aggcgactcc atcatcatcc ggaaaggaaa aggagacatg
    12241 cgcatcaagg tgtacgaaga gcagttggaa gacggagaaa agaaagaagt acaaatttat
    12301 gaaggagtct atctcgagaa agtggatgca gacaagcgca ctttcctcga cgccctgcca
    12361 ttcatcccca aaaagagaag atacaatgct tacgaaccgc actgttccgg tctgtatatt
    12421 ggctacagcc ggctggctaa cgacttcctt tccttcggag caagcgacaa gatgggactc
    12481 gacttatcca agtcatggga attcggcttc aacatcctct ccgtatatca caacttcaag
    12541 aagaacccgc attggggaat caacctggga gtcagctggg gataccgttc tttcaatatc
    12601 gacggtaact atgccttgct gaaggaaaac ggaaccagca tcttcaccgc aggcaacgaa
    12661 gacaccagtt acaataaaag ccgtctgcgc catttcttct tccgtgtacc cgtattgatg
    12721 gaatggcagc aaagagtggg aagaaacaaa gtgttcttca atgccggtcc cgaatttgag
    12781 atacgtcaca gcgtgaagtc attctcacac atcaacggag gcaagaagaa aaccgtaggc
    12841 aaaggtatgt atgtgcagcc cgtcggcata aacctgctgg cacaagccgg ttatggtaat
    12901 atcggcattt acctgcgcta ctccacatac ggattattcc agaaagacaa gggaccggaa
    12961 gtatctccct attcatttgg cgtggcatgg tatctgtaat ccctccccta taacacaaga
    13021 ctccccgaaa tgtatttgta cattccgggg agttctttta taccctaagg tattgacaat
    13081 gaaaggttat ctgcaatgaa aattgttctt ctaaaaacgc atgcccaatg taaatagcac
    13141 tttactgcga gtgttggtaa cttccgttgt tggcggtgtt accaagccat ttatatcatt
    13201 ataaaacgga tagaaatcag atttataagt atcgaattta taagccaaat ccgcataaaa
    13261 cgaagaaaag cgataaccga tacctaaagt gaaagtattc atcgatttgc tattggcaaa
    13321 atccgtatct gtatttatag aattggaagg caatgcctta atagcatcct ttttataggc
    13381 tgcagtactg taattgtaac cggcacgcag agagaaagca ggtatcggct tgtattctgc
    13441 tcctaaacga agcgtactta cccccttcat acagaggtca gcctcacccg tttcccatgc
    13501 catctcgtca ccttcaggat atttgaactt catgcttgag tagtcctcat attcatattc
    13561 agctcccaaa gccagattat taccgactgt atagcccaaa cttgcattaa atacccacgg
    13621 ggtttgcagc ttaaaatcac ggtccatatc tctaccgcct aatg
//
