LOCUS       gnlProkkaNMOHCABM_65   22758 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NMOHCABM_65.
ACCESSION   gnlProkkaNMOHCABM_65
VERSION     gnlProkkaNMOHCABM_65
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 14:37:20
            Original ID  :: gnl|Prokka|NMOHCABM_65
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 172322
            Orig. end    :: 195080
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..22758
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:12758]"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12758
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     cand_cluster    1..22758
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..22758
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="1"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     CDS             411..1247
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     136.6; E-value: 1.6e-41)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg65_153"
                     /transl_table=11
                     /translation="MNTAIVKRAFRYIFRGIPRPHISIAVKNFTTRRLEGRKILITGGG
                     KGIGYWIAKKCVSEGAKVLICGRQEETLRRACRELGESCQYIKFDVSSIIDIPSFLNEA
                     FLRMNGIDSLVSNAGISLHEGSFKNVTESGFDAQFKVNFKAPYFLAKYFVEKIENEKIG
                     SANILFVTSERGSFCTSIPYGLTKSSLKSYVGALCRYYCFNERIRVNAIAPGVTSSEMT
                     GYSENGDFQTDDSPNGRIFHPAEMANVACFLLSDEASCISGETIHCDFGRHQSVID"
     CDS             1435..2112
                     /locus_tag="ctg65_154"
                     /transl_table=11
                     /translation="MSKISHSPVAIIVEEAYLPNTYTALTEAWLQRVQVIVLALNSMNL
                     DSSFYLNRCVDASILIDNVETIEGVVCNAIQHHGPSLIKIKEEVNEEKKIDYTNLFSII
                     DLCAKDKKVLCYNPQYGNKDYEFIPPEYKYGVISKYVGQLIGGKQSVLCIPEYLLALDT
                     NIFNFRDFPDGFKLIVKYSDGVCWGRLNTWMQRNNINTYVVDGRSFEYTTMNFKPNYAI
                     LVK"
     CDS             2118..3851
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 61.1;
                     E-value: 1.4e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg65_155"
                     /sec_met_domain="TPP_enzyme_N (E-value: 5.1e-23, bitscore:
                     75.4, seeds: 75, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTKIKQVQQIVSLLKQNNIRHFVLSPGTRHVAFVHIVEMDPFFR
                     CYSIVDERSAAFFALGLSEALDEPVGFACTSATASCNYMPAMKEAYERNIQLVALTSDK
                     QRYQRFHGVSQVINQVDMFAPYCRYAVDLPEVNDSMDEWFCNRCINEALLEMDHHGRGP
                     IQINFLEPSSIDELSIFYDGNMPVCRKINRIEDWSQINEWKNVLAAKKRILVVCGQYQE
                     FTGCLRSSIRKFYEKYNCAVSFDAFSNVADKDFIQTMLLSITLNQKELLSLKPDLIITF
                     GTKYFSDIVSRFAGMGIEHWEINFEGRIFDTSRSLTKIFEFTPEEFFDKVSYNITTNDK
                     QYDKLWRALNESRDNSIDEFTNYYVAKKVLESLPEGSNVHASVLNSMKFTNMSKLPQNT
                     IATGNNCADGIDGALSTFIGQAEVLDSLSLLVIGDLSYLYDLNAAIHDFKNNTRVLLIN
                     NFAGGEFHFNIGKKKISTLEQHIAAGHHTKIQDAIGLSNFQYIAVHNKGELEEKLSLFL
                     RESENPILMEVFTNPELDGSSLKKLIRNNIKMTPERLIAGFVNKFLDCRTKYAIKKFLH
                     R"
     CDS             3884..4987
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045:glycosyl transferase group 1 (Score: 95.5;
                     E-value: 6.7e-29)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg65_156"
                     /sec_met_domain="Glycos_transf_1 (E-value: 6.7e-26,
                     bitscore: 84.8, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVLIYGFTGNVLGGIEVYTLNMSEYMSDDCVFDYIVDGDECAYR
                     ERITKRGGKIFFVPWVRRHPLGYINKLWRIFGEEKKSGTNILYHQLFTMSNLIPDVIAK
                     LRGYKVILHAHNNGLQKGGRMYLMAHNLGKILSRFCGFVMFTNSQLSSDYMFGKGVNSK
                     LIYNAIDVGKFAFKQEHRDCIRKELDCQSKTVIGFVGRLVDQKNPLFMLKVFAEIHKLR
                     PNSELWIIGEGILRGKMEVEINEQGICSSVKWLGRREDVNRLMQGMDLLLQPSVFEGLG
                     IVLVEAQATGLAVVSSEVVIPKEAVISDRIKLLPLSEKSAYWAAESVNLLDSCCESYDR
                     TNAIVPDCYNIQHEAKRLESMLKELIS"
     CDS             4992..6161
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Wzy_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg65_157"
                     /sec_met_domain="Wzy_C (E-value: 2.2e-07, bitscore: 24.9,
                     seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIIPVKTSKWFTYYLLFLPLVMMYSVPGTGIRIPTLLTAIAMLYS
                     LLQLANRHMRVPIYMLLPLFMYLTYVMFKSSLQLAFLCGSVIIIISAICTGIVNVFLLR
                     KVLEKVAIVAAFCVIFQQIVHILTGIHFHFYLLPFFANDLLEQYNNAITTGAVEGMYRP
                     CAFFLEPAQYSQYCTIGLGSCLFTHRPKTKNALFISLGIFASTSGMGFVSVFAIWGAWA
                     LSRQKTKKNFIRSLPVILIALFLVFFLLDNISFTHNIINRFTSTSGDDYNAINGRLFWW
                     DTYFGDFNVSDFLTGFGLDNLPDGVYFTGFMKLLYCYGLIGTTLLLLFLGMLIIKADIF
                     VKVCTSLYTGLLFFADLTYYHNLIFYIGVYLALYIFNKERVNIAGTLKA"
     CDS             6267..6644
                     /locus_tag="ctg65_158"
                     /transl_table=11
                     /translation="MDIGENAVIARTAVLDKNINPQGVHIGKNTWVLRDAIILAHDHCR
                     GKNGKGRLFDTRIGKNCVIGIRSIILPGVTVGDHCVVAAGAVVTKNAPPNSIIAGNPAV
                     VIKTGVVISDGGQIIERGEKI"
     CDS             6647..7255
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Bac_transf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1146:sugar transferase (Score: 240; E-value: 8.8e-73)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg65_159"
                     /sec_met_domain="Bac_transf (E-value: 3.4e-63, bitscore:
                     206.2, seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYKHFFKRPFDFIISLVALICLSPILLAVTIWLHFANKGAGAFFI
                     QARPGKDAEIFKVIKFKTMKDEFDEKGEPLPDEVRLTKVGKIVRSTSLDELPQLLNVLK
                     GDMALIGPRPLMPEYLELYTPEQMRRHEVRPGITGWAQIHGRNELPFTERFEYDVYYVD
                     HLTFGLDLKIFFMTIVKIFKREGISQKGQATVETFDGTN"
     CDS             7270..7905
                     /locus_tag="ctg65_160"
                     /transl_table=11
                     /translation="MKHLVIIGGGGMGKDIYHSAKHSIGYGTEYDIKGFIDDNLNSLDG
                     CEGYPPVLDTIKNYQPSEDDVFTCSIGNVKTKRTLCEMIKDRGGKFITLLHETAQLGEN
                     VKLGDGCIIDSHAHIGSDTIIGENCLVQTFAGIGHDCRVGDYCRIDVRAFLVGGVRIEE
                     NVTIHTNAILNHHVVVEKDAVVAALSFVVRKVKAGTTVFGNPAKLLKY"
     CDS             7942..8172
                     /NRPS_PKS="Domain: PP-binding (6-70). E-value: 1.6e-08.
                     Score: 26.8. Matches aSDomain:
                     nrpspksdomains_ctg65_161_PP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg65_161"
                     /sec_met_domain="PP-binding (E-value: 6.8e-08, bitscore:
                     26.8, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELNEFIENFAEQFDDTDASEIKADTVFKELDEWSSLVALSVIAM
                     VDEEYDITIKGDEIWNSNTVEDLFNAIKAKA"
     aSDomain        7960..8151
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg65_161_PP-binding.1"
                     /evalue="1.60E-08"
                     /label="ctg65_161_PP-binding.1"
                     /locus_tag="ctg65_161"
                     /protein_end="70"
                     /protein_start="6"
                     /score="26.8"
                     /tool="antismash"
                     /translation="IENFAEQFDDTDASEIKADTVFKELDEWSSLVALSVIAMVDEEYD
                     ITIKGDEIWNSNTVEDLFN"
     CDS             8178..8924
                     /NRPS_PKS="Domain: PKS_KR (10-168). E-value: 1.3e-10.
                     Score: 33.3. Matches aSDomain:
                     nrpspksdomains_ctg65_162_PKS_KR.1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     177.9; E-value: 4.1e-54)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg65_162"
                     /transl_table=11
                     /translation="MYNPYSLTGKTILVTGASSGIGRATAIECAKLGAKVVITARNEDR
                     LKETLDTLEGEGHQMICFDLSETEKLNDFVASLPPVQGFVSNAGTTIIAPIKFIKEDSL
                     EGLLQVNTVSPILLLQRLLKKRILGKGSSVVFTSSMAALGKGTPGNTMYSASKGAISAF
                     IQNAALELSAQRIRVNAVCPGTVDTPLIHSGGITDEQLSEDAKKYPLGYGQPEDIALGI
                     AYLLSDAAKWVTGTNVIIDGGLSVSC"
     CDS_motif       8208..8300
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg65_162_0001"
                     /evalue="9.80E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg65_162"
                     /protein_end="41"
                     /protein_start="10"
                     /score="15.0"
                     /tool="antismash"
                     /translation="TILVTGASSGIGRATAIECAKLGAKVVITAR"
     aSDomain        8208..8681
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg65_162_PKS_KR.1"
                     /evalue="1.30E-10"
                     /label="ctg65_162_PKS_KR.1"
                     /locus_tag="ctg65_162"
                     /protein_end="168"
                     /protein_start="10"
                     /score="33.3"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TILVTGASSGIGRATAIECAKLGAKVVITARNEDRLKETLDTLEG
                     EGHQMICFDLSETEKLNDFVASLPPVQGFVSNAGTTIIAPIKFIKEDSLEGLLQVNTVS
                     PILLLQRLLKKRILGKGSSVVFTSSMAALGKGTPGNTMYSASKGAISAFIQNAA"
     CDS             8941..9999
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) fabH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084:3-oxoacyl-(acyl carrier protein) synthase III
                     (Score: 204.7; E-value: 3.1e-62)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg65_163"
                     /sec_met_domain="fabH (E-value: 5e-50, bitscore: 164.3,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKIKINNVRIKGIAACAPSKVEENSEYPYFDENEFENIIPSIGV
                     ERRHVAKEGQTCADFAQRAAEKLMEELGWEKESIDLLIFGSPSKDYIQPDTACVLQGKL
                     DLPESCMAFDMTLGCTGWTYGMTNACSLMQTGCIKRVLLLNGIQGSAESCYYDKTGYPL
                     FSDVATATALEYDPTAAPIYCELGTIGKQFDAILVPDGGRRNPVTEGSLKLVEYEKNVK
                     RNRLHTFMKGMDVFSFALKTAPKSTNAVLEFAGKEKDEIDYFFFHQANFYMVKKIIKKL
                     KIDPEKAPIVMKDFGNTGACSIPFTMVIGCAEKLRNGKHTNVGCSFGVGLSWGSLCFET
                     ENLVIPELQIYD"
     CDS             10001..11533
                     /NRPS_PKS="Domain: AMP-binding (9-409). E-value: 1.8e-80.
                     Score: 262.4. Matches aSDomain:
                     nrpspksdomains_ctg65_164_AMP-binding.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     314.7; E-value: 1.5e-95)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg65_164"
                     /sec_met_domain="AMP-binding (E-value: 3.4e-83, bitscore:
                     273.3, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSQLADLFYKNAAEMPDKQAIWCDGKTATYQEMANRVSRYSNYL
                     VAKGVQYGDHVAIPMNNSIESVALFFSAADLGVCLVPLNPTLPLESIKVAMKSGDMKHL
                     IARKSFLNECEKKGGVDVPGITVCLDGEFEGAFPFSEVATMPTTRPACENIKGDESLIL
                     TMTSGSTGTPKPIDISQQNKIDRSLAHIRVYGLVKEDRILAATPLYHSLAERLVIMPLL
                     LGATSILLPRFTPALWLKCAAEQKPTFTIAVSAQLAQILELLKQENTESIDSFHTIVSS
                     SALLEEKVKLELIDRLQCEFHEMYGTSETSTATDICFQKARNKQKSVGLPFDEAEVKIL
                     RDDEDTECAVGEVGEIAVKSKLTCKGYYKLKNMMDMATTEGFFRTGDLGYMDEDGYLYF
                     AGRKKELIITGAINVYPNDVDAVVNQLTAVEECAAFSYPDERLGEVVALAVVVKEDCEL
                     TERTIKTYCAKNLADFQQPHKIFFVDMLPKNTMGKLQRNRILDHIRNVGIDK"
     aSDomain        10028..11227
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg65_164_AMP-binding.1"
                     /evalue="1.80E-80"
                     /label="ctg65_164_AMP-binding.1"
                     /locus_tag="ctg65_164"
                     /protein_end="409"
                     /protein_start="9"
                     /score="262.4"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="YKNAAEMPDKQAIWCDGKTATYQEMANRVSRYSNYLVAKGVQYGD
                     HVAIPMNNSIESVALFFSAADLGVCLVPLNPTLPLESIKVAMKSGDMKHLIARKSFLNE
                     CEKKGGVDVPGITVCLDGEFEGAFPFSEVATMPTTRPACENIKGDESLILTMTSGSTGT
                     PKPIDISQQNKIDRSLAHIRVYGLVKEDRILAATPLYHSLAERLVIMPLLLGATSILLP
                     RFTPALWLKCAAEQKPTFTIAVSAQLAQILELLKQENTESIDSFHTIVSSSALLEEKVK
                     LELIDRLQCEFHEMYGTSETSTATDICFQKARNKQKSVGLPFDEAEVKILRDDEDTECA
                     VGEVGEIAVKSKLTCKGYYKLKNMMDMATTEGFFRTGDLGYMDEDGYLYFAGRKKELII
                     T"
     CDS_motif       10490..10534
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg65_164_0001"
                     /evalue="8.60E-04"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg65_164"
                     /protein_end="178"
                     /protein_start="163"
                     /score="12.4"
                     /tool="antismash"
                     /translation="TMTSGSTGTPKPIDI"
     CDS             11549..11800
                     /NRPS_PKS="Domain: PP-binding (29-72). E-value: 7.4e-07.
                     Score: 21.5. Matches aSDomain:
                     nrpspksdomains_ctg65_165_PP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg65_165"
                     /sec_met_domain="PP-binding (E-value: 3e-06, bitscore:
                     21.5, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDIKEFVTEYIQREYTVPEDVDIMTLNYIEAGYIDSMAFIQFIS
                     TIEDEYDIEFEVEDIENPKLRIVGKLIDFIQAKIDEQH"
     aSDomain        11636..11764
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg65_165_PP-binding.1"
                     /evalue="7.40E-07"
                     /label="ctg65_165_PP-binding.1"
                     /locus_tag="ctg65_165"
                     /protein_end="72"
                     /protein_start="29"
                     /score="21.5"
                     /tool="antismash"
                     /translation="IEAGYIDSMAFIQFISTIEDEYDIEFEVEDIENPKLRIVGKLI"
     CDS             11808..12758
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271:2-isopropylmalate synthase (Score: 93.1; E-value:
                     3.2e-28)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg65_166"
                     /sec_met_domain="HMGL-like (E-value: 1.3e-23, bitscore:
                     77.8, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRNIEGIKIVDATIRDGGLVNDFFFTDEFVKKVYETNVAAGVDYM
                     EFGYRADKKMFDPSKFGKWKFSSDEDIFSIVGDNPTGLKLCVMADVGRCDFKNDIHKKS
                     DSPLSLIRVATYIETFSEAIEMIEFAAKQGYEVTCNLMAISKCTMMQLSKALDALAQTP
                     VMGVYIVDSYGALYPKEVRKLTRHFQDHLSPYGKLTGIHAHNNQQCAFANTIEAHDLNA
                     KMLDATYYGMGRGAGNCHLEALLGYFNGKKYHVEPVLDLVGSDMLVMKDQEPTWGYNTS
                     YLIAGLANAHPRDAIAATKKKDTNFVEQYKFQIYK"
     CDS             13162..13677
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DHQ_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1183:3-dehydroquinate synthase (Score: 121.2; E-value:
                     7.5e-37)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg65_167"
                     /sec_met_domain="DHQ_synthase (E-value: 4.3e-52, bitscore:
                     170.7, seeds: 76, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVDASISGKTAVDLQAGKNLIGAFWQPSLVVADTQVVTNLPADIF
                     AEGMAEVIKSDLIANAGIVEMIRQNTIKERIDQMVASCIKMKRDVVEQDEYETKGLRKV
                     LNMGHTVPHAIEKLSNYSISHGVAVATGLVWEAKIACHLELCASGLVDEIRAAVDAYQL
                     YYDVPYTV"
     CDS             13824..15005
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079:oxidoreductase (Score: 76.5; E-value: 3.9e-23)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg65_168"
                     /transl_table=11
                     /translation="MEQVTIGMAGAGRATELHIMALKRFLGVPVRLKTIVARRKEQLEE
                     AQRLYGFEQISYSFDDMINDPEIDVIDICTPPYAHEEMIEKAMMAGKHVICEKPLTGYF
                     GTPGDEEPIGDKVPKRVMYLKMLEQIRYLRTVIKKTGKKFMYAENFVYAPAVRKTAEII
                     KAKKSRILFMKGEESLKGSSSPVAGEWSKTGGGTMIRTGAHPLSAILWLKQQEAQARGV
                     EIKVKSVLGVMDRITPQLNEYEHRHIAARPHDVEDFGTIILDFTDGTKAVVIATDTLLG
                     GSKNYVELYCNDAAINCNLTMSNLMSTYFLDEDNLDDIYISEMLPSKTGWNNPFLEDEI
                     IRGYTDEMRDFMECVYYDREPQSGFTLAYDTIKIIYAAYMSAELGNKVELNAF"
     CDS             15008..16042
                     /locus_tag="ctg65_169"
                     /transl_table=11
                     /translation="MDFLKKLPTPEELAKIYPLSKGMAKKKLEHDKEIKKIFSGESKRL
                     LLNIGPCSADRMDAVLEYAARLAEIQKEVVENILIVPRVYTSKPRTIGKGYMGMIHQPY
                     IGQGEDLSMGVAAVRNVHRQVVEETGLFPSDELLYPETIHYLADLLGYAVIGARSVENQ
                     QHRLVASGLNIPVGLKNPISGSINVMLNAIETAQHPHHFIFNGWEVMSKGNEYAHGVLR
                     GYLEEGGAATRNCDYEHLSEICDRFAVRNVENPAVVVDCNHSNSDKQYMRQIDNAMEVL
                     GLMKEYPKIKKLVKGLMIESYLEDGNQPIDGGVYGKSVTDPCLGWEKSKQLIYDINEKL
                     EGLK"
     CDS             16039..16254
                     /locus_tag="ctg65_170"
                     /transl_table=11
                     /translation="MSERPKKIFCFDNYPEAKMALGKVTYPVIIKPYECEDKTFWFEAS
                     DYGKAGQVLYDAFEHTRNGWVMIEEH"
     CDS             16230..16955
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170:metallo-beta-lactamase family protein (Score:
                     98.8; E-value: 5e-30)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg65_171"
                     /transl_table=11
                     /translation="MGDDRGTLSMNSYKAFIEEREVSIYRFPYELVDSNMFFIPSGDTG
                     IVFDPNENEELLRVFQELGTRSVEIVLTHEHYDHTTGVKWLQSKIETRLFCHRACAEAI
                     ATEKGNDPKTLGYILTLRDAVDGGHRRENFLATAKRYMLRADEAFDGDCGLKVGELVLR
                     CHPAPGHSPGSALYFLGETAFFSGDSLIQHTPTIVHLPGSDRRAYKQETKPYLRSLDKD
                     MMVFPGHGEPFKLGEAEFL"
     CDS             17078..17500
                     /locus_tag="ctg65_172"
                     /transl_table=11
                     /translation="MALDLYIFYFYFRDLNLKLFQVMNMSEFYSDFLYRYQTEAAPLNV
                     SIDSFCLREGVEYRNFIRWYRDNKKRLRESEMADIRISAIKVTGAPALTAPVNPPIAFC
                     TVSEFHLKLSNGIEIHKPDSHLEDITNLLSSLSRVC"
     CDS             17494..17826
                     /locus_tag="ctg65_173"
                     /transl_table=11
                     /translation="MLGLSSHMNFYLCEGFVDMRKGIATLSELVRRKLHKDPESGDVFI
                     FLGKDRRNIKILRHEYNGYVLYWQKLNRERFLLPVFNSDLNQYEISWDKLVVLLQGTVR
                     KGLLVG"
     CDS             complement(17762..17905)
                     /locus_tag="ctg65_174"
                     /transl_table=11
                     /translation="MQIKNCAVYLTTNILINTQKSVFCIHFNQPKALYEQCLEEALQAY
                     PN"
     CDS             complement(18278..18577)
                     /locus_tag="ctg65_175"
                     /transl_table=11
                     /translation="MSRKNILKGVQGFITFKRGIIVTDSAFGVNQSGNFENMLTHIPIH
                     FIQYPMTNIDWAGISRDLITVTVVHHGRFYLSGILAIIRTVGFGLCCLAHKSIR"
     CDS             complement(18622..19263)
                     /locus_tag="ctg65_176"
                     /transl_table=11
                     /translation="MQHLGSHQKLALLFAKVYQEQVMLFVAVPFYVHLLIKSVFCNQIL
                     SSKVRRSGSLLRQSVHPYSSIYKFSPHMRHTSITGNSLSMPVKKFINIVTIRGNITKKI
                     FEMVLGNCHTAATPVIQVISNLQGRILAAPDILLLVFHLSRFLVFDSDQFSSPITEQKL
                     SLLKRRFRNGVSCLPNRSVCFCIQLSTVEEENFAPASEKRATPRSEERLY"
     CDS             complement(19606..19830)
                     /locus_tag="ctg65_177"
                     /transl_table=11
                     /translation="MSMSQKQGLYRSALFLNTLLYRSNIPNIYQYMPIFPLNRQYISIG
                     GENRIDNLRMFFVSTHCTASLVFTASSLL"
     CDS             19867..20247
                     /locus_tag="ctg65_178"
                     /transl_table=11
                     /translation="MYPDCIVYTSSFGKEALGSDKLNFSRYHNDPVIWMGDNVTVLHEN
                     DKVEIFPGIFVEVFETPGHDKSCLTYKVENNVFSGDSYIPGVKVIASFPNSDREDARIS
                     KERIMELTKDCSLYPGHGNIYE"
     CDS             20354..21604
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056:DegT/DnrJ/EryC1/StrS aminotransferase (Score:
                     259.1; E-value: 1.1e-78)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg65_179"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 8.8e-87,
                     bitscore: 285.5, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 6.3e-07, bitscore:
                     22.7, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKTIYLCLAHMSEEGIEQKYVKEAFDTNWVVPLGPNVNAFEEDL
                     KRFVGEGKEVVALSAGTAAVHLALLACGVGQGDEVIVQSFTFCASSHPVTYLGAVPVFV
                     DSEKETWNMSPELLEEAIKDRIAKTGKKPKAIVPVALYGMPYDCTRIMEIADRYAIPVV
                     EDAAEGFGSRFKGQVLGTFGKFGVLSFNGNKMITTSGGGALICKDAESKNQIMWYATQA
                     REAYPYYQHEAIGYNYRMSNICAGIGRGQMTVADKHIAHHRHVQALYKELLKDVEGVLL
                     HEAPSADYDSNFWLCTITLDSSLRIKGQENAYKDVVRTAVGGAAGVIHAVDCATTDCQP
                     NENVEALRAFMLGKKIEARPVWKPMHKQPVYKDAPAYINGVSEAIFKIGMCLPAGPWVT
                     DEDVYYIVECIKEAIVK"
     CDS             22079..22579
                     /locus_tag="ctg65_180"
                     /transl_table=11
                     /translation="MPLFYYARQSSLATKEGAKLWHLSLKKVGRAVDAQQLAEVIAEKS
                     SLTPGDVHNVIRNLMTVMRSQLLNSRTVRLDGLGTFTMKARTRGKGVVKSEDVNPNQVT
                     ALRCQFTPEYTRPAAIGTTRALLQGVEFEKWTGVVTDGKDDAGDGGNSGGGSDGDQGEN
                     PLG"
     CDS             22612..22707
                     /locus_tag="ctg65_181"
                     /transl_table=11
                     /translation="MKKNVWDKILKVVIAVASAILGALGANAMNV"
ORIGIN
        1 ccttcggttt tagctattga ctccacaatg cagttggcac aacagacagg atatcgtgtt
       61 gttagtttcg gttacatgca aaaaaacata gagaatcata tagatggtgg accatgggag
      121 tttctttcta tgattgatgg ggcggaatat gtgatgacgg attccttcca tgccacagtg
      181 ttcgctttac tatttcataa aaatttttat gtgtttgata ggcaatatgt gcataaacaa
      241 tctcagtcat caagaataac agatttgttg gcattactaa atttatccga tagatataat
      301 acaattcata ttgataataa taatataaat tattcgcttg tagatgaagt tttatcgact
      361 tatagacaag agtatgacaa tttttgcaaa cagattttta gaaatattat atgaatacgg
      421 caattgttaa aagggcgttt agatacattt ttcggggaat accacggcca catattagta
      481 ttgcggtaaa aaattttacg acacgacgtc ttgaaggaag aaaaatttta ataactggtg
      541 gtggcaaggg aataggttat tggattgcca aaaaatgcgt atctgaagga gcaaaagtgt
      601 tgatttgcgg aaggcaagaa gaaactctcc gcagagcttg ccgggaatta ggcgaatctt
      661 gtcaatatat taagtttgat gtttctagta ttattgacat accatctttt ttaaatgaag
      721 cgttcttaag aatgaatggt atagatagcc ttgtgagtaa tgcgggtata tctttacatg
      781 agggctcttt taaaaatgta acggagagtg gttttgatgc tcagttcaaa gttaatttta
      841 aggcaccata ttttcttgct aaatatttcg ttgaaaaaat cgaaaatgaa aagataggct
      901 ctgctaatat tctattcgtt acatcggaac gtggaagctt ttgtacttct ataccatacg
      961 gccttactaa gtcatcttta aaaagctatg ttggtgcatt gtgtcgttat tattgtttta
     1021 atgaacgtat acgagtaaat gcaattgccc caggagtaac ctcatctgaa atgacaggat
     1081 atagtgaaaa cggagatttt caaactgatg acagcccaaa cggccgtata tttcatccgg
     1141 cagaaatggc taatgttgct tgcttcttac tcagtgatga agcatcgtgt attagtggag
     1201 agactattca ttgtgatttt gggagacatc agagtgtaat cgattagtat aggaaaaaca
     1261 tgaacatcaa ataggttttt tatgattgat agcattattt cgtgtttaaa cgctaaaggt
     1321 gtagtaagat ttgttaatac aactacacag ataaaagaaa aaatatcata cccttccaat
     1381 atagaatggt attatattga agatgttaga agtgctgttt ttaacgcata tggaatgtca
     1441 aagattagcc attctccagt tgctattata gtggaggagg cctacttacc taatacatat
     1501 actgcactca cggaagcatg gcttcaaaga gtgcaagtga ttgtattggc actgaatagt
     1561 atgaatttgg atagttcgtt ctatttgaat aggtgcgttg atgcatctat cctaatcgat
     1621 aatgtggaaa caattgaagg tgtagtatgt aatgctattc aacatcatgg accttctctt
     1681 ataaaaataa aggaggaggt aaacgaagaa aaaaagattg attataccaa tctattttca
     1741 attatagatt tgtgcgcgaa ggataaaaaa gttttatgtt ataatcctca atatggtaat
     1801 aaagactatg aatttatacc accagagtat aaatatggtg ttatttcaaa atatgtagga
     1861 caacttatag gaggaaagca atcggtttta tgtattccag aatacttatt ggcattggat
     1921 acaaatatat ttaatttcag ggattttcct gacggtttca aattaattgt aaaatactcc
     1981 gacggtgttt gttgggggcg tcttaatact tggatgcaga ggaataacat caacacatat
     2041 gttgtagacg gtcgttcgtt tgaatatacg acaatgaatt ttaagcccaa ttatgcaatc
     2101 ttagtaaaat agaggttatg aagacaaaga taaaacaggt acagcagatt gtatcattat
     2161 taaaacaaaa taatatacga cattttgtcc tttcgccagg gacgagacat gtggcctttg
     2221 tacatattgt tgaaatggat ccctttttta ggtgttattc tatcgtagac gagcgaagtg
     2281 ccgcattttt tgctcttgga ctctctgagg cattagatga acccgttggt tttgcttgta
     2341 catcagctac tgcatcatgc aattatatgc cggctatgaa ggaggcttat gagagaaata
     2401 ttcagttggt agcattaact tcagacaagc aaagatatca gagatttcat ggtgttagtc
     2461 aagtaataaa ccaagttgat atgttcgcac catattgtcg atatgctgta gatttgcccg
     2521 aagtgaatga ttccatggat gaatggttct gcaatcgttg tattaatgaa gcattgttag
     2581 aaatggatca tcatggaaga ggccctattc aaataaactt tctagagccc agtagcattg
     2641 atgaactatc catcttttac gatggtaata tgcctgtgtg tcgaaaaata aatagaattg
     2701 aggattggtc acaaattaat gagtggaaaa atgtacttgc agcaaaaaaa agaattcttg
     2761 ttgtttgtgg tcagtatcag gagtttacag ggtgtttaag gtcaagtata agaaagtttt
     2821 atgagaaata taattgtgcg gtatcatttg atgcgttttc aaatgttgca gacaaagact
     2881 ttattcaaac aatgttgttg tcaataacac ttaatcagaa ggaactgcta agtttgaaac
     2941 cagatcttat tattacattt ggaacaaaat atttctcaga cattgtctca cgttttgcgg
     3001 gaatgggaat tgaacactgg gaaatcaatt ttgaaggtcg tatttttgac acaagcaggt
     3061 cgcttactaa aatattcgag tttactccag aggaattttt tgacaaagtt tcctataata
     3121 tcacgacaaa cgataagcag tatgataaat tgtggagggc tttgaatgaa agccgagata
     3181 attctataga tgaatttact aattattatg ttgcaaaaaa ggttttggaa tctttgcccg
     3241 aaggcagtaa tgttcatgca agtgttctga atagtatgaa attcacaaat atgagtaagc
     3301 tcccacaaaa tactattgca acaggtaaca attgtgcaga tggaatagat ggagctctct
     3361 ctacttttat tggccaagcc gaagtgcttg atagtctctc gctgcttgtt ataggggatt
     3421 tgagctattt atatgatcta aatgcagcta tccatgactt taaaaataac actagagttt
     3481 tactcattaa taattttgcg gggggcgaat tccattttaa tattgggaag aaaaaaatat
     3541 ccacacttga acagcatata gcggctggac atcatacaaa aatacaagat gctattggtt
     3601 tatctaattt tcaatacata gctgttcata ataaaggcga attagaagaa aaactttcac
     3661 tttttttgcg ggaaagtgaa aatccaattt taatggaggt ctttaccaac cctgaactcg
     3721 atggttcttc cttgaaaaaa cttattcgaa ataatataaa aatgacacca gaaaggctga
     3781 tagctgggtt cgttaacaag ttcctagatt gtaggactaa atatgcgata aaaaaattct
     3841 tacatagata aaagtaatat aatcttttag tattattcga ttaatgcgtg tattaatata
     3901 cggttttacc ggaaacgttt taggggggat tgaggtatat accctcaata tgagcgaata
     3961 catgtctgat gattgtgtgt ttgattatat tgttgacggg gatgaatgtg catatagaga
     4021 acggataacg aaaagaggtg gaaaaatatt ttttgttcct tgggtaagaa gacatcctct
     4081 tgggtatata aacaaattgt ggcgtatttt tggtgaagag aagaagtctg gcacaaatat
     4141 attatatcat caactattta caatgtctaa cctcatacca gatgttattg caaaacttag
     4201 gggatataag gtaattttac atgctcataa taatggacta cagaaaggcg gaagaatgta
     4261 tttgatggca cacaatttag gaaaaattct ttcgagattc tgtggttttg tgatgttcac
     4321 aaattcccag ttgtcctcag attatatgtt tgggaagggt gttaattcga agcttatata
     4381 taatgctatt gatgttggga agttcgcttt taaacaagaa catagagatt gtataagaaa
     4441 agaattggac tgtcagagca agacggtaat aggatttgtt ggtagacttg tagaccagaa
     4501 gaatcctttg ttcatgctta aagtcttcgc tgaaattcat aaacttcgtc cgaatagtga
     4561 gctttggata attggagaag gaattttgag aggaaaaatg gaagtagaaa taaacgagca
     4621 agggatatgt tcatcagtaa aatggcttgg acgaagagag gatgtcaata gattgatgca
     4681 aggaatggat cttttgttac agccgtcagt atttgaaggc ttaggaatag tacttgttga
     4741 agctcaagca acaggccttg ccgttgtttc ctcagaagtc gttataccaa aagaggcagt
     4801 gatttctgat agaataaagc tcttaccgct tagcgaaaaa tctgcatatt gggctgctga
     4861 aagtgttaat cttttagatt cgtgctgtga atcttatgat agaaccaatg caatagttcc
     4921 agattgttac aatatacagc atgaggcaaa gagacttgaa agcatgttaa aagaactgat
     4981 tagttaataa gatgattata cctgttaaaa ccagtaagtg gttcacttat tatctattat
     5041 ttctcccgtt agtaatgatg tacagtgtgc ctggtactgg aatacggatt cctacgcttt
     5101 tgacagcaat tgcaatgttg tattctctct tgcagttagc caataggcat atgagagtgc
     5161 caatttatat gttattacca ttgttcatgt acttgacata tgtgatgttt aagagttctt
     5221 tacaacttgc atttctttgc ggcagtgtga taattattat atcggcaatc tgtacaggta
     5281 tagtaaatgt ttttttatta agaaaagtac tggaaaaggt cgcaattgtc gctgcattct
     5341 gtgtaatctt ccagcaaatc gttcatatcc tgacaggcat acatttccat ttttacctcc
     5401 ttcctttttt tgcaaatgat ttgttggaac aatacaacaa tgcgattact accggagctg
     5461 ttgagggaat gtataggcca tgtgcatttt tcttagaacc tgcacagtat tcacaatatt
     5521 gtacaatcgg tcttgggtct tgtttgttta cccatagacc aaagacgaag aatgctcttt
     5581 ttatttctct tggtatattt gcaagtactt caggaatggg atttgtttca gtgtttgcta
     5641 tttggggggc ctgggctctt tcaaggcaaa aaactaagaa aaactttatc aggagtttac
     5701 ctgtaatcct tatcgcactt tttttggtgt tttttttatt agacaatatt agttttacac
     5761 ataatattat aaaccgtttt acttcaacct caggtgatga ttataatgcc attaatggga
     5821 ggctgttttg gtgggataca tattttggtg attttaatgt atctgatttt ttaacaggtt
     5881 ttggcttgga taatttacct gatggagtct attttacggg ttttatgaaa ctattatact
     5941 gttacggttt gataggaacg acactattgc tactattcct tggcatgcta ataatcaaag
     6001 cggacatctt tgtaaaggtg tgtacatctc tatacacggg attgctgttt tttgctgatt
     6061 tgacttatta tcataattta atcttttaca taggagtata tcttgcattg tatattttta
     6121 ataaggaaag agtcaatatt gcaggaacat tgaaagcctg aaatggatat aaaaaaatgg
     6181 ataaaaataa ttcttttaat cttcgtgctt ggttatgggg taagatgaca tctttatacc
     6241 ccaaatatct taaatggcat tttaagatgg atataggtga gaatgcagta atagcacgga
     6301 ccgcagttct ggataaaaac attaaccccc aaggtgttca tattggtaaa aatacatggg
     6361 tgttgagaga tgctattatt ctggcacatg atcactgcag aggcaaaaat gggaaaggaa
     6421 ggttatttga cactcggatt ggaaagaatt gtgtgattgg tattcgcagt atcattctgc
     6481 ccggtgtaac cgttggagat cattgcgttg tagccgcagg tgctgttgta accaaaaatg
     6541 ccccccccaa ctccataata gccggcaatc ctgcggtagt tattaagacg ggcgttgtga
     6601 taagtgatgg agggcaaatt attgaacgcg gagaaaaaat ataaatatgt ataagcactt
     6661 ctttaaacgt ccatttgatt ttattatcag tttggtcgct ctgatttgtc ttagccccat
     6721 attgttggct gtgaccattt ggcttcattt tgccaacaaa ggggctggag cattctttat
     6781 tcaagccaga cccggtaagg atgctgagat attcaaggtg atcaagttta aaacaatgaa
     6841 ggatgagttt gacgaaaaag gcgaaccgtt acctgatgag gtcaggctta ccaaagtggg
     6901 aaaaatagta cgctcaacat cattagacga attgccacag ctgcttaatg tgttgaaagg
     6961 tgatatggca ttgataggcc ccagacctct gatgccggaa tatctggagc tttatacgcc
     7021 tgagcaaatg cgccgtcacg aggtaagacc aggcattacc ggatgggcac agatacacgg
     7081 gcgtaatgag ttgcctttta ccgagcgctt cgagtatgac gtgtattatg tggatcatct
     7141 gacctttggc ttagacctga aaatattctt tatgaccatt gtcaaaattt tcaaaagaga
     7201 aggaatatcc cagaaaggtc aggctacagt agagacattt gatggaacaa actaatatgg
     7261 aataacataa tgaaacattt ggtaataata ggcggcggag gaatgggtaa ggatatttac
     7321 cattcagcca agcattccat tggttatgga acagagtatg acataaaagg attcatagat
     7381 gacaatctga attccttgga tggttgtgag gggtatccgc cagtcttaga tacaataaag
     7441 aactatcagc cttcagaaga tgatgtattt acctgctcta tcggtaatgt gaaaacaaag
     7501 agaacgctct gcgaaatgat aaaagacagg ggggggaagt tcattacctt gctacatgag
     7561 acagcccaat tgggagaaaa tgtgaaactt ggtgatgggt gtatcatcga tagtcacgcc
     7621 cacataggat cagatacgat tataggcgag aattgtttgg tgcagacgtt tgctggaatt
     7681 ggtcacgact gtagggttgg tgattattgc cgcattgatg tcagggcatt tcttgttgga
     7741 ggcgtacgaa tagaagaaaa tgtaactata cataccaatg ccatattgaa ccaccatgta
     7801 gtagtggaga aagatgcagt ggtagctgca ttaagctttg tggttagaaa ggtcaaggct
     7861 ggaactaccg ttttcggtaa tccagccaaa ctgttgaaat attaaataaa acaagtaata
     7921 ataattgaat tattgaaaat tatggaatta aacgaattta ttgagaattt tgcagagcag
     7981 tttgacgaca ccgatgccag cgagattaag gcagacaccg tttttaagga actggacgag
     8041 tggtcatcgc ttgtggctct gagcgtgata gctatggtgg acgaggaata tgatattacc
     8101 atcaagggtg atgaaatctg gaattccaat accgttgagg acttgttcaa cgctataaaa
     8161 gccaaagcat aaacaatatg tataatccat attctctaac agggaagacc attctggtga
     8221 ccggtgcttc gtccggcata ggccgtgcaa cggctatcga atgtgctaag cttggagcaa
     8281 aggttgtcat tacagcccgt aatgaggata ggctgaaaga aacgcttgat acgctggagg
     8341 gtgaaggaca tcagatgatt tgtttcgact tgtctgaaac ggagaaactg aatgactttg
     8401 ttgcaagcct tcctccagta caaggctttg tgagcaatgc tggaactaca ataatagctc
     8461 ctattaaatt tattaaggaa gatagtctcg aaggattgct acaagtaaat acggtttccc
     8521 ctattctact tttgcaaaga ctacttaaga aaagaatatt aggcaagggc tcttctgttg
     8581 tattcacaag cagcatggct gcacttggaa aaggcacacc cggtaatacg atgtacagtg
     8641 catctaaagg tgccattagt gctttcatcc agaatgctgc actggaattg agtgcccaga
     8701 gaatcagggt aaatgcagtg tgtccgggca ctgttgacac tccccttatt catagtggtg
     8761 gcattactga tgaacagttg agtgaagatg caaaaaaata tcctctcggc tatggacagc
     8821 ctgaagacat tgcattggga atagcatacc tcctttcaga tgcagccaag tgggttacgg
     8881 gaacaaatgt aattattgac ggagggttat ccgtcagttg ttgaaacaag gattactatt
     8941 atggcaaaaa taaaaataaa caacgtaaga atcaagggca tcgcagcctg tgcaccatcg
     9001 aaggtggagg agaacagcga atatccttac tttgacgaga acgagttcga aaacattata
     9061 ccaagtatag gcgtggaacg tcgccatgta gctaaggaag gtcagacgtg tgctgacttt
     9121 gcccagcgag ccgctgagaa actgatggaa gagttgggat gggagaaaga aagcatagac
     9181 ctgctcatct ttggctcccc ttccaaagac tatatccagc cggacacggc ttgtgtgctg
     9241 caaggcaagc ttgacctgcc ggaatcgtgc atggcattcg acatgactct gggctgcaca
     9301 ggctggacat acggcatgac caatgcctgt tcactgatgc agacagggtg catcaagcgt
     9361 gtactgttac tcaatggtat acagggttct gcggagagct gctactacga caagaccggc
     9421 tacccgctgt tcagcgatgt ggccactgct actgctttag aatatgatcc aacagcggca
     9481 cccatctatt gtgaactggg caccataggt aaacagtttg atgccattct tgttcctgac
     9541 ggaggtcgca ggaatcccgt gacagaaggg agtctgaaac tggtggagta tgaaaagaat
     9601 gtgaagcgaa accgtctgca cacctttatg aagggaatgg atgtgttctc ctttgccctg
     9661 aagactgccc ccaagagcac caatgcagtg ctggagtttg caggtaagga aaaggacgag
     9721 attgactact tcttcttcca tcaggccaac ttctatatgg tgaagaaaat catcaaaaag
     9781 ctgaagatag acccggagaa ggcacccata gtgatgaaag acttcggaaa cacaggtgct
     9841 tgcagtatac cctttacgat ggtgataggt tgcgcagaga aactgcgcaa cggaaagcat
     9901 accaatgtgg gctgttcgtt tggcgtgggt ctttcatggg gaagcttgtg ctttgagaca
     9961 gaaaacttag tgatacccga actgcaaata tacgattaat atgagaagtc agttagcaga
    10021 tttgttttat aagaacgcag cagagatgcc tgataagcag gctatctggt gcgacggaaa
    10081 aacagccacc tatcaagaga tggcaaatcg ggtgagccgc tattcgaact accttgttgc
    10141 gaaaggtgtt cagtatggtg accatgtggc catccccatg aacaatagca tagaatcagt
    10201 tgcgctgttt ttcagtgcgg cagacctggg cgtatgtctg gttccgctga accctacact
    10261 ccctttggag tcaattaagg tggccatgaa gtcgggcgac atgaaacacc tgatagcccg
    10321 caagagtttc ctgaacgaat gcgagaagaa aggtggagtg gacgtgcctg gcatcaccgt
    10381 atgcctagac ggagagtttg aaggagcatt ccctttcagt gaggtggcaa cgatgcctac
    10441 tacacgtcct gcctgtgaga atatcaaggg cgatgagagt ctgatactga ccatgacctc
    10501 cggctctacg ggaacaccga agccaattga catttctcag cagaacaaaa tagaccgctc
    10561 gctggctcat atccgagtgt atggactggt gaaggaagac agaatactgg ctgctacacc
    10621 gctgtaccac tccttggcag agcgcctggt gattatgccg ttgcttttgg gtgcgacctc
    10681 tatcctgctg ccacgattca ctccggcctt gtggctgaag tgtgccgcag aacagaaacc
    10741 gacgtttacc attgcggttt ctgcccagtt ggcgcagata cttgaactgc tgaagcagga
    10801 gaataccgaa agtatagaca gcttccacac aatcgtttct tcatcagccc tgctggagga
    10861 gaaggtgaag ctggaactga tagaccgttt gcagtgcgag ttccacgaga tgtatggcac
    10921 ctcagagaca tctacggcta ctgatatttg cttccagaag gcccgtaaca agcaaaagag
    10981 tgttggcctg ccctttgatg aagcggaagt gaagatacta cgtgacgacg aggataccga
    11041 atgcgctgtg ggcgaagtgg gagagattgc cgtgaagtcg aagctgacct gtaagggcta
    11101 ctataagctg aaaaacatga tggatatggc taccaccgaa gggttcttcc gtactggtga
    11161 cttaggctat atggacgagg atggctatct ctactttgcc ggacgcaaga aggagttgat
    11221 tatcacagga gccatcaacg tatatccaaa tgatgtggat gccgtagtga accagttgac
    11281 cgctgtggaa gaatgcgcag ctttctccta tcctgacgaa aggcttggtg aagtagtggc
    11341 actggctgtg gtggtgaagg aagattgcga actgacagag cgcaccatca aaacctattg
    11401 cgccaagaac ctggcagact tccagcagcc acacaagatt ttctttgtgg atatgctacc
    11461 gaagaacaca atgggtaagc tgcagcgcaa ccgcatacta gaccatataa gaaatgtagg
    11521 aatagacaaa taaaaagaaa ttacgactat gacagatatt aaagaattcg tgacagaata
    11581 tattcagcgc gaatacaccg tacctgaaga cgtcgatatt atgactctca actatattga
    11641 ggcaggctat attgactcta tggctttcat tcagtttatc tctaccatcg aagacgagta
    11701 tgatattgag tttgaggtgg aggacataga gaatcctaaa ctgaggatag taggcaagtt
    11761 gattgatttt atccaagcca agatagacga acagcattaa gaccgtcatg agaaatatag
    11821 aaggaataaa aatagtagat gccactatcc gtgacggggg actggtgaac gacttcttct
    11881 ttaccgatga gtttgtaaag aaggtctatg aaaccaatgt ggctgcaggt gttgactaca
    11941 tggagtttgg ctatcgtgca gacaagaaga tgtttgatcc cagtaagttc ggtaagtgga
    12001 aattttcctc ggacgaggac atcttcagca ttgtgggtga caacccgacg gggctgaaac
    12061 tgtgtgtcat ggcagacgtt ggacgctgtg acttcaagaa cgatatccac aagaagtcgg
    12121 atagtccgct gagccttatt cgtgtggcta cctatataga gaccttttcg gaagctatcg
    12181 agatgataga atttgccgcc aagcaaggct atgaggtgac ttgtaacctt atggccatct
    12241 caaaatgtac gatgatgcag ttgtcgaaag ccttggatgc actggcccag acaccagtga
    12301 tgggcgtgta tatagtggac agttacggag cgctctatcc caaggaagtc cgtaaactga
    12361 ccaggcactt ccaagaccat ttgtcaccct acggcaaatt gacaggcatc catgcccaca
    12421 acaaccagca gtgtgccttc gccaacacca tagaggcaca cgacctgaat gccaagatgc
    12481 tggatgccac ctattatggc atgggacgag gtgctggcaa ctgtcacctg gaggcattgc
    12541 ttggctattt taacggcaag aagtatcatg tggagcccgt gttggacttg gtgggaagtg
    12601 atatgttggt catgaaagac caggagccca cttggggcta caatacatcg tatctgattg
    12661 ccggactggc caatgcccat ccgagggatg ctattgccgc cacaaagaaa aaagatacta
    12721 attttgtgga gcagtataag ttccagatat acaagtaagc gtggaaacga tagtggtaaa
    12781 cacctcaagg aagtaggatg tcctgttggg gcagggagtc attgctgact tgccccggct
    12841 ggtagagcca ttctgtaaag gagggaaggt gggggtcatc acggatgata ccgtagatgc
    12901 cctgtatgct gcaaaggcgg tatgggcaat ggaacaatac ggatatgatg tatgtaaata
    12961 cgtcatccca tacggagaga gttccaagaa cataaatact ctgtcaggta ttttggagta
    13021 ttttgcttcc tgtcatttta cgagaaagga cattttcctc tccattggtg gtggtgtgat
    13081 aggggggaca ttacgggagt gcccgctgca ctgtatatgc gaggcatcca ttttattcaa
    13141 atgcctacta cgctactctc tatggttgat gcctcaataa gtggcaagac agctgttgac
    13201 ctgcaggcag ggaagaactt gataggcgct ttctggcaac cttcattagt ggtggcagac
    13261 acacaagtgg taaccaacct accagcagac atctttgcag aaggcatggc agaggtcatc
    13321 aagagcgacc tgatagctaa tgccggtatt gtggagatga tacgacagaa cacaatcaag
    13381 gagcgtatag accagatggt ggccagttgc atcaagatga aacgcgacgt ggtggaacag
    13441 gatgagtacg agaccaaagg actccggaaa gtgctgaaca tgggacatac cgttccccat
    13501 gctattgaga aactctccaa ctatagtatt tcacatggtg ttgctgttgc aacgggactg
    13561 gtatgggagg ctaagatagc ttgtcatctg gaactgtgtg cttccgggct tgttgatgag
    13621 atacgcgctg cggtggatgc ctaccaactc tactacgacg taccctatac cgtatagaat
    13681 atggtggaag ccatgaaaaa cgacaagaag aatgacgaca gcaggataga cttcgtattc
    13741 cctatcgagt acagtaaatg ggaggaaaga agactagaac agaaagagtt aatgaatatt
    13801 atcaaaacac taaatatctg aatatggagc aagtaaccat tggaatggcg ggtgccggac
    13861 gcgctacgga attgcacatt atggcattga agcgcttttt aggtgtgcct gtcaggttga
    13921 agaccatcgt tgcaagacgt aaggaacagc tggaggaagc ccagcgtctt tatggctttg
    13981 agcagatttc gtacagcttt gacgatatga tcaacgaccc tgagatagat gtcatagaca
    14041 tctgtacgcc tccctacgct cacgaggaga tgatagagaa ggctatgatg gcaggcaagc
    14101 acgtgatatg cgaaaagccg ctgacgggct atttcggaac tcccggcgat gaagagccta
    14161 tcggtgacaa ggtgccgaaa cgcgtgatgt atctgaagat gttggagcag atacgctacc
    14221 tgcgcactgt tatcaagaaa accggcaaga agttcatgta tgcagagaac ttcgtgtatg
    14281 cccctgccgt gagaaagacc gcagagatta tcaaggccaa gaagagccgt atcctgttca
    14341 tgaaaggaga ggagagcctg aagggatcca gttcgcccgt ggccggagaa tggagcaaga
    14401 ccggcggtgg caccatgatt cgtaccggtg cacatcctct ttcggccatc ctctggctga
    14461 aacagcagga agcccaagcc cgtggagtag agattaaagt aaagagcgtg ctgggcgtga
    14521 tggatcggat cacaccccaa ttgaatgaat acgagcaccg gcatattgcc gccagaccgc
    14581 atgacgtaga agatttcggg actatcatac tggactttac cgacggcacc aaggccgtgg
    14641 tgatagctac cgacaccctg cttggcggtt cgaagaacta tgtggaactg tattgtaacg
    14701 atgctgccat caactgcaac ctcaccatgt ccaacctgat gagcacttac ttcctggatg
    14761 aggacaactt ggatgatatc tatatttcag agatgcttcc ttccaagaca ggatggaaca
    14821 accccttcct ggaggatgag ataatacgag gctatactga cgagatgcgt gattttatgg
    14881 agtgcgtgta ttatgaccgt gagcctcagt cgggtttcac tttggcatat gataccataa
    14941 agattattta tgcagcctat atgtcagcag aacttggcaa caaagtggaa ctaaacgcat
    15001 tctgattatg gatttcctga agaaacttcc tacaccggaa gaattggcta agatataccc
    15061 gttgagtaag ggaatggcca aaaagaagtt ggagcacgat aaagagataa aaaagatatt
    15121 ctccggggag tcaaaaagac tgctattgaa tatcggtcct tgctctgcag acaggatgga
    15181 tgccgtactg gagtacgctg cacgccttgc agagatacag aaagaggtgg tcgagaatat
    15241 tcttattgtg cctcgtgtct ataccagcaa gcccagaacc attggtaaag ggtatatggg
    15301 tatgattcac caaccctata tcgggcaggg tgaagacctg tcgatgggtg tggcggctgt
    15361 gcggaacgta caccggcaag tagtggaaga gactggattg ttcccatcgg atgagctctt
    15421 gtaccctgaa actattcact atctggcaga cctgttgggc tatgctgtta ttggagcacg
    15481 ttcggtagag aaccagcagc ataggctggt ggccagtgga ctaaatattc ctgttggcct
    15541 aaagaatccc ataagtggca gtatcaacgt aatgctgaat gccattgaga ccgcccagca
    15601 tccgcaccat tttattttca atggatggga agtgatgtca aagggcaatg agtatgcaca
    15661 cggcgtactt cgaggttatc tggaagaagg cggtgccgca accagaaact gcgactatga
    15721 gcacctgtcg gagatttgtg accgtttcgc agtaaggaat gttgaaaatc ctgcggtggt
    15781 ggtggactgc aaccacagca attccgacaa gcagtatatg cgtcagatag acaacgcaat
    15841 ggaggtgctg ggcctgatga aggaataccc caagattaaa aaattggtga aggggctgat
    15901 gatagagagc tatctggaag atggcaacca gcccattgat ggaggagtgt atggaaagtc
    15961 tgtgactgac ccatgccttg gttgggagaa gtccaaacaa ctaatatatg acattaacga
    16021 aaaattagag ggactgaaat gagcgagcga ccgaagaaga tattctgttt tgacaactac
    16081 ccggaggcga aaatggcatt gggaaaagtg acgtaccctg tcatcatcaa gccatacgag
    16141 tgtgaagaca agacattctg gtttgaagcg tcggactatg gtaaagccgg tcaggtgctg
    16201 tatgatgcct ttgaacacac ccgaaatgga tgggtgatga tagaggaaca ctgagtatga
    16261 actcttataa ggcttttata gaggaacgcg aggtgtcaat ctatcggttc ccctatgagt
    16321 tggtggattc caatatgttc tttattccat caggggacac tgggattgta tttgacccaa
    16381 atgagaatga agagttgctc cgagtatttc aggaactggg gacaaggagc gtggaaatag
    16441 tccttacgca tgagcattat gaccatacga cgggggtaaa gtggttacag tcgaagatag
    16501 agacgagact gttttgccat cgcgcctgtg cagaagctat tgccactgag aaagggaatg
    16561 accctaagac actggggtat atactgacgc tacgtgatgc ggttgacggt ggacacagaa
    16621 gagagaactt tctggctacc gctaagcggt atatgcttcg tgcagacgag gcatttgacg
    16681 gtgattgtgg gttgaaagta ggtgaactgg ttttgagatg tcatccggca cctgggcaca
    16741 gcccggggag tgccttgtat ttcttgggtg agacagcgtt tttttcaggc gattccctta
    16801 tacagcatac accgaccata gtgcatctgc cagggagtga cagaagagcc tataagcagg
    16861 aaaccaagcc atatttgcgg tcactagaca aagatatgat ggttttccct gggcacgggg
    16921 agccgtttaa gttgggggaa gcagaattcc tttaaatatt ggtgctatga gtaagaagat
    16981 gaagattaca ttgcttgctg ccatggtggc agttggtgct ttgtacataa tttgtttgca
    17041 attgatttaa aaactaagat atgtaagcac tcactgtatg gctcttgatt tgtatatctt
    17101 ctatttttac tttcgtgact taaacttaaa attattccaa gtcatgaaca tgtctgaatt
    17161 ctacagcgat tttttatatc gctatcaaac cgaggcagca cctttgaacg tatctattga
    17221 tagcttctgc ttgcgcgaag gtgttgagta ccgcaatttt atccgttggt atcgtgataa
    17281 caagaaacgt ttacgcgaaa gtgaaatggc tgatattcgt attagtgcta tcaaagtgac
    17341 cggagctcca gcattgactg ctccagtaaa tccccccatt gctttttgca ctgttagcga
    17401 gtttcatttg aaactttcca atggcattga gattcataaa ccagattccc acctggaaga
    17461 tattactaac cttttaagta gtttgtcacg cgtatgttag gtttgagctc tcacatgaat
    17521 ttctaccttt gtgaaggttt tgttgatatg cgtaaaggta tcgccaccct ttcggagttg
    17581 gtacgccgta aattgcataa ggatcctgag tcgggtgatg tatttatttt ccttggaaaa
    17641 gaccgtcgta atataaagat tctgcgccat gagtataatg gatatgtgct ttactggcag
    17701 aaactgaacc gtgaacgctt ccttcttcct gttttcaatt ccgatttaaa ccaatacgaa
    17761 atcagttggg ataagcttgt agtgcttctt caaggcactg ttcgtaaagg gcttttggtt
    17821 ggttaaaatg aatacaaaaa acgctctttt gagtgttgat taatatgttg gttgtcagat
    17881 aaacagcgca gttttttatt tgcataattt attaaaaatg agtatattca cttcatgcaa
    17941 gacaaagata ttatcaacat attaatctct caattacttt ccaaggatga tgagttacgc
    18001 catcaacgtt cccgtctgga gactccgttt ggctaactct gaacaggaaa agtctgatct
    18061 gagggaagcc ttgaaagctt tgcagcaaac tcgtgcggat gacctgtttg aacttgaaag
    18121 acaaaaacgg caactttacg gtaggagttc aggaaaggtt aaaagcctga agaagctaca
    18181 ggaaagaagc gtgaaagaag ataaggatga ttttgatggt ttcaatcccc ctgggcttcc
    18241 tcctcatgag ggacatgccc tccttgatac tatgagatca tctgatgctc ttgtgggcca
    18301 ggcagcaaag tccaaacccc accgttcgga ttatggcaag aatgccactc agatagaatc
    18361 taccgtgatg cactactgta accgtgatca agtccctgct gatgcccgcc caatcaatgt
    18421 tcgtcattgg atactgtata aaatggattg gaatgtgtgt aagcatgttt tcgaaattcc
    18481 cagactgatt gactccgaag gcgctatcag taactattat gccccgtttg aaggtgatga
    18541 agccttgcac ccctttgaga atgttcttcc gggacatcat gtaggtatgg atatgatagc
    18601 acagatcatg gtagataaat atcagtatag cctctcttcg gagcggggtg tagctcgttt
    18661 ttcagatgcc ggtgcaaagt tttcctcttc cactgtactg agttggatac aaaaacacac
    18721 agatctgttg ggcaaacagg aaaccccgtt gcggaatctt cttttgagca aagacagttt
    18781 ttgttctgtg atgggactac tgaactggtc agaatcaaaa acaaggaaac gggaaagatg
    18841 gaatacaaga agcagtatat ctggggcagc aagaatccgg ccttgaaggt tgcttattac
    18901 ctgtatgacc ggggtagccg cagtatggca gttgccgaga accatttcaa agattttttt
    18961 ggtaatatta ccacggatgg ttacaatgtt tataaacttt ttgaccggca tcgaaaggga
    19021 gttacccgtt atggatgtat ggcgcatgtg cggcgaaaat ttgtagatgc ttgaatacgg
    19081 atgaacgctc tgtcgaagta gtgaacctga tctccgaact ttactggata gaatctgatt
    19141 gcaaaataca ctttttatca gaagatgaac gtagaaagga acggcaacaa agagcattac
    19201 ctgttcttga taaactttgg caaataataa agccaatttt tgatgcgacc caagatgctg
    19261 catccaatct ctttatcaag gcgatccggt atgctgttgc cgaatgggag tcaatatgct
    19321 gctatgtgaa taatggtaaa gcagagattg acaacaatac agctgaacgg atgatgaagc
    19381 ctatttgcct gggtcgtaac aattatttgt tttgcggggc agaaccgggt gcaaagaata
    19441 cttctttatt atactcaatt attgagactt gcaaaatgaa tgggctaagg cctgttaaat
    19501 acattgcgga tgttttaagg aagttggtgg ccggcgcaac gaattacgcc gcacttttac
    19561 ctatcaatat agcgaaataa acataatttt taaataaaaa ataactcaaa gtaggctaga
    19621 ggcggtgaaa accaggctag ccgtacagtg agtgcttacg aaaaacatcc tcagattgtc
    19681 aattctgttt tcacctccaa tgcttatata ctgtctgttg aggggaaaga ttggcatgta
    19741 ttgatagata ttggggatat tgctcctata aagcagtgtg ttcaggaaaa gtgcggaacg
    19801 gtacaagcct tgtttctgac tcatactcat tacgaccata tttatggtat aaaagattta
    19861 ttacgattgt atcctgattg catagtttac acttcctctt tcggtaagga ggctttaggt
    19921 tcggataaac ttaatttttc ccgttatcac aatgatcctg taatatggat gggagataat
    19981 gtgacggttt tacatgagaa tgataaagtg gaaatatttc cgggaatttt cgtggaagtg
    20041 tttgaaactc ccggacatga taaaagttgc cttacctata aagtcgagaa caatgttttc
    20101 tcgggtgatt catatatccc gggtgttaaa gtcattgcct cattccctaa tagcgatagg
    20161 gaagatgcac ggatctcgaa agaacgtatc atggaattaa caaaggattg cagtctgtat
    20221 cccggtcatg gaaacattta tgagtaaatt attccgatat ctggaaagga tttataaagc
    20281 cgtttccttt ctttttattc cccactatgt gaggaatccg aagtttgatc attaaataat
    20341 cacatatata tttatggata aaactattta tctttgcctt gcccatatga gcgaggaggg
    20401 tattgaacag aaatatgtaa aagaagcctt cgatacgaac tgggtggttc ctctcggtcc
    20461 taatgtgaat gcttttgaag aggatttgaa acgttttgta ggcgaaggca aggaagtggt
    20521 ggcactttcg gccggtacgg cggcagtaca tttggctctg ttggcttgcg gagtgggaca
    20581 gggtgacgaa gtgattgtac aaagcttcac attctgtgcg tcttcgcatc cggtcactta
    20641 tctgggggct gttccggtat ttgtggattc tgagaaagaa acttggaaca tgtctccgga
    20701 actgttggaa gaagccatca aggaccgcat tgccaagact ggaaaaaagc caaaagctat
    20761 tgttcctgtg gcattgtacg gcatgcccta tgactgtaca cgtatcatgg agatagccga
    20821 taggtatgct attccagtgg tggaagatgc tgccgaaggt tttggctccc gttttaaggg
    20881 acaggtactg gggacgttcg gcaagttcgg ggtgctgagc tttaacggta acaagatgat
    20941 tactaccagt ggcggtggtg cgttgatttg taaagatgcc gaaagcaaga atcaaatcat
    21001 gtggtatgcc acgcaggctc gtgaggctta tccttattac cagcatgagg cgatagggta
    21061 taactatcgc atgagtaata tatgtgcagg tattggtcgt ggtcaaatga ccgttgccga
    21121 taagcatatt gcacatcacc gacatgtgca ggctctctat aaggaactgc ttaaggatgt
    21181 ggagggggta ttgctgcatg aagctccttc ggctgattat gactctaatt tctggctttg
    21241 tacaatcact ctggattctt cacttcgcat caaagggcag gaaaatgctt ataaggatgt
    21301 tgtcaggact gccgtaggtg gtgctgcagg tgtgattcat gccgtagatt gtgctacaac
    21361 agattgccag cccaacgaga atgtggaggc tttgcgtgct tttatgcttg gcaaaaaaat
    21421 agaggcacgc ccggtttgga aaccgatgca caagcagccg gtctataagg atgctccggc
    21481 ttatatcaat ggggtatccg aagctatttt taaaatcggt atgtgccttc ctgccgggcc
    21541 gtgggtgact gatgaagatg tatattatat cgtggagtgt ataaaagagg ccatagtaaa
    21601 ataatagatg aaaatacagc ttttttaact acgaccttga caacgctgtc ggttgccaat
    21661 acgtttgtca atgcggattt catctatacc gttgtctgtt ccgttctagt cttctgcttc
    21721 ttcaatttct gcaagcgtgc caaatattca ccgcctgatg cttcatgaga atatcggact
    21781 accgcatcgc aaacatctta tcagattatg gcgaatgagc tgaagattcc ccatgtcata
    21841 gtatctttga cctatatggc agtacaggca atcatcatcg taggatatct tgattaagtt
    21901 ggcttgccta atctgtcgac ttgtaaatca atactttata aacttatctc agaaaacagc
    21961 ttcagcgagg ctgttttctt tgtttgcagg caaatatatc ctcacctttg cattgttgat
    22021 caacaaaacg agattaaaaa ccatgttgaa ttaaaaatgt aaaaaggaga aagaaagtat
    22081 gcctttattt tattatgcaa gacagtcgtc tctggcgaca aaagagggtg ccaaactttg
    22141 gcatctgagt ttgaagaaag tgggaagagc cgtggatgca caacaattgg ctgaggtgat
    22201 tgccgagaag tcttccctga ctccgggtga cgtacataat gtaatccgta acctgatgac
    22261 ggtaatgagg agccagttgc tgaacagccg tacggtgcgt ctggatggct tgggcacatt
    22321 caccatgaag gcccgtacgc gaggtaaggg agtggtcaaa tctgaagacg tgaatcccaa
    22381 tcaggtgact gctttacgtt gccagtttac tccggaatac acgcgcccgg ctgccatcgg
    22441 cactacgcgt gccctgctcc aaggggtgga gtttgagaaa tggacgggag tggttacgga
    22501 cggtaaggat gatgccggtg atggtggtaa ttccggtggc ggttccgacg gtgaccaggg
    22561 agagaacccg ttaggataag atgtatttac taattttgaa agattaaaac tatgaaaaag
    22621 aacgtttggg acaaaatttt gaaggtagtg atagctgttg cttccgccat attgggagct
    22681 ttaggcgcca atgcaatgaa tgtataaatt gtagatttat atagaatatt aggagaaagg
    22741 cggtgaaggg aaagcact
//
