LOCUS       c00002_gnlPro..        14495 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EIDNDILN_2.
ACCESSION   c00002_gnlPro..
VERSION     c00002_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 14:08:56
            Original ID  :: gnl|Prokka|EIDNDILN_2
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14495
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..318
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_1"
                     /sec_met_domain="ILVD_EDD (E-value: 2.8e-37, bitscore:
                     121.7, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="YIKSRHLGKECALITDGRFSGGTSGLSIGHVSPEAAAGGNIGKIV
                     DGDIIEIDIPARTINVRLTDEELAARPMTPVTRDRYVPKSLKAYASMVSSADKGAVRLI
                     D"
     protocluster    1..14495
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[0:4495]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1..4495
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..14495
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14495
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             366..2063
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_2"
                     /sec_met_domain="TPP_enzyme_C (E-value: 7.9e-47, bitscore:
                     152.2, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKDLITGAEAMMRSLEHQGVTTIFGYPGGSIMPTFDALYDHQNT
                     LNHILVRHEQGAAHAAQGYARVSGKVGVCLVTSGPGATNTITGIADAMIDSTPIVVIAG
                     QVGTGFLGTDAFQEVDLVGITQPIAKWSYQIRRAEDVAWAIARAFYIASSGRPGPVVLD
                     FAKNAQVEKTKYEPTQQEFIRSYVPVPDTDEESVKAAAELINNAERPLVLVGQGVELGS
                     AQEELRTFIEKADMPAGCTLLGLSALPTEHPLNKGMLGMHGNLGPNINTNKCDVLIAVG
                     MRFDDRVTGNLATYAKQAKVIHFDIDPAEVNKNVKVDIAVLGDCKKTLAAVTGLLKKNR
                     HTEWVDSFKEYEAVEEEKVIRPELHPATDSLSMGEVVRAVSEATRHEAILVTDVGQNQM
                     ISARYFKYTKERSIVTSGGLGTMGFGLPAAIGATFGRPDRTVCVFMGDGGLQMNIQELG
                     TIMEQKAPVKIICLNNNYLGNVRQWQAMFFNRRYSFTPMLNPDYMKIASAYDIPSKRVF
                     SREELKAAIDEMLSTDGPFLLEACVVEEGNVLPMTPPGGSVNQMLLEC"
     CDS             2082..2645
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_3"
                     /sec_met_domain="ALS_ss_C (E-value: 8.8e-19, bitscore:
                     60.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDKTLYTIIVHSENIAGLLNQVTAVFTRRQINIESLNVSASSIK
                     GVHKYTITAWTDKDTIEKVVKQIEKKIDVIQAHYFTEDEIYFHEIALYKVSTPAFQETP
                     EASKVIRRYNARIVEVNPVFSIVEKNGMSEEITSLYEELRALKCVLQFVRSGRVAITTS
                     CFERVNEFLDGQEAKYKQSKKEQE"
     CDS             2645..3388
                     /locus_tag="ctg2_4"
                     /transl_table=11
                     /translation="MSEENKIGTYQFVAEPFHVDFNGRLTMGVLGNHLLNCAGFHASDR
                     GFGIATLNEDNYTWVLSRLAIELDEMPYQYEKFSVQTWVENVYRLFTDRNFAVIDKDGK
                     KIGYARSVWAMINLNTRKPADLLALHGGSIVDYICDEPCPIEKPSRIKVTSNQPVATLT
                     AKYSDIDINGHVNSIRYIEHILDLFPIELYQTKRIRRFEMAYVAESYFGDELSFFCDEA
                     NENEFHVEVKKNGSEVVCRSKVIFE"
     CDS             3452..4495
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_5"
                     /sec_met_domain="IlvN (E-value: 5.3e-46, bitscore: 149.5,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 2.8e-39, bitscore: 128.0,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGTVENVVIRDEFPLEKAREVLKNETIAVIGYGVQGPGQ
                     ALNLRDNGFNVIVGQRQGKTYDKAVADGWVPGETLFGIEEACEKGTIVMCLLSDAAVMS
                     VWPTIKPYLTAGKALYFSHGFAITWSDRTGVVPPADIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAIYQDATGNAMDRTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMG
                     PFHDAIKPVVEKLYHSVKTGNEAQISIDSNSKPDYREKLEEELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(5031..6977)
                     /locus_tag="ctg2_6"
                     /transl_table=11
                     /translation="MKYIFVSGGRFTTFASIMNNHPKSPIIDLQQQQLLLRMEYEHEKE
                     EFKRQTETMGVARKVKRGLCWYPASPGRSYYNSLNQLVIDITRTENKEIEHSFEFGRPV
                     CFFRQSFDGKVNYMNFIASVSYADDERMVVVLPSAGALLELQTEEVLGVQLYFDETSYR
                     AMFEALEDTIRAKGNRLAELRDTLLGTQKPGFRELYPVRFPWLNSTQETAVNKVLCTRD
                     VAIVHGPPGTGKTTTLVEAIYETLHREPQVLVCAQSNTAVDWICEKLVDRGVPVLRIGN
                     PTRVNDKMLSFTYERRFENHPAYPELWGIRKSIREMGSRMRRGSYSEREGMRSRMSRLR
                     DRATELEILINADLFDSARVIASTLVSSNHRLLNGRRFPTLFIDEAAQALEAACWIAIR
                     KADRVILAGDHCQLPPTIKCIEAARGGLDHTLMEKVVQQKPSAVSLLKMQYRMHEAIMR
                     FPSEWFYNGELEAAPEVRNRGILDFDTPMNWIDTSEMDFHEEFVGESFGRINKQEANLL
                     LQELEAYINRIGKARILDESIDFGLISPYKAQVQYLRSKIRGSSFLRPFRSLITVNTVD
                     GFQGQERDVVFISLVRANEDGQIGFLNDLRRMNVAITRARMKLVILGDATTLAKHAFYR
                     KLIQYIRQEAVSS"
     CDS             7044..9287
                     /locus_tag="ctg2_7"
                     /transl_table=11
                     /translation="MVYDLTMLEAFYSAYKGKVEHVRAVLKRPLTLAEKILYAHLFNEG
                     DLKNYKRGEDYVNFRPDRVAMQDATAQMALLQFMNAGKEKVAVPSTVHCDHLIQAYKGA
                     KEDIATATKTNEEVYDFLRDVSSRYGIGFWKPGAGIIHQVVLENYAFPGGMMVGTDSHT
                     PNAGGLGMVAIGVGGADAVDVMTGMEWELKMPRIIGVRLTGKLSGWTSPKDVILKLAGI
                     LTVKGGTNSIIEYFGPGTASLSATGKATICNMGAEVGATTSLFPFDGRMATYLRATGRD
                     RIVELAEAVDCELRADQQVTDEPEKYYDRVIDIDLSTLEPYINGPFTPDAATPISEFAE
                     KVLLNGYPRKMEVGLIGSCTNSSYQDLSRAASLARQVKEKNLSVASPLIINPGSEQIRA
                     TAERDGMMDDFMQIGAVIMANACGPCIGQWKRHTDDPMRKNSIVTSFNRNFAKRADGNP
                     NTYAFVASPELTMALTIAGDLCFNPLKDRLMNHDGEKVKLAEPVGDELPLRGFTSGNEG
                     YIAPGGTKAAINVNPASQRLQLLTPFPAWDGQDILNMPLLIKAQGKCTTDHISMAGPWL
                     RFRGHLENISDNMLMGAVNAFNGETNNVWNRSTNTYGTVSGTAKMYKSEGIPSIVVAEE
                     NYGEGSSREHAAMEPRFLNVRVILAKSFARIHETNLKKQGMLALTFADKADYDKIQEHD
                     LLSVIGLPDFAPGRNLTVVLHHEDGTKESFEAQHTYNEQQIAWFRAGSALNAR"
     CDS             9302..10492
                     /locus_tag="ctg2_8"
                     /transl_table=11
                     /translation="MNKITMQKDGTLSVPDVPVVPYITGDGVGAEVTPSMQAVVNAAVQ
                     KAYGGKRRIEWKEVLAGERAFNETGSWLPDETMKAFQEYLIGIKGPLTTPVGGGIRSLN
                     VALRQTLDLYVCLRPVRWYQGVHSPVKAPEKVNMCVFRENTEDIYAGIEWESGTPEAEK
                     FYQFLKNEMGVTKVRFPETSSFGVKPVSREGTERLVRAACQYALDHHLPSVTLVHKGNI
                     MKFTEGGFKKWGYELAQREFGDALADGRLVIKDCIADAFLQNTLLIPEEYSVIATLNLN
                     GDYVSDQLAAMVGGIGIAPGANINYKTGHAIFEATHGTAPNIAGKDVVNPCSIILSAVM
                     MLEYLGWKEAAALIEKALEQSFLDARATHDLARFMPGGTSLSTTAFTREIVERIEK"
     CDS             10518..11861
                     /locus_tag="ctg2_9"
                     /transl_table=11
                     /translation="MKKEYLIYKLSEEMKEATRIDNELFPKFDVKRGLRNEDGTGVLVG
                     LTKIGNVVGYERIPGGGLKPIPGKLFYRGYDVEDISHAIIKEKRFGFEEVAYLLLSGRL
                     PDKEELASFRELINDNMALEQKTKMNIIELEGNNIMNILSRSVLEMYRFDPDADDTSRD
                     NLMRQSIDLISKFPTIIAYAYNMLRHATFGRSLHIRHPQEKLSIAENFLYMLKKDYTEL
                     DARTLDLLLILQAEHGGGNNSTFTVRVTSSTGTDTYSAIAAGIGSLKGPLHGGANIQVA
                     DMFHHLQENIKDWKSVDEIDTYFTRMLNKEVYNKTGLIYGIGHAVYTISDPRALLLKEL
                     ARDLAREKGKEEEFAFLELLEERAIATFGRVKNNGKTVSSNIDFYSGFVYEMIGLPQEI
                     FTPLFAMARIVGWCAHRNEELNFEGKRIIRPAYKNVLDDLAYIPIKKR"
     CDS             12360..13121
                     /locus_tag="ctg2_10"
                     /transl_table=11
                     /translation="MSITAFNLFLGVMSLIALIVFIALYFVKAGYGIFRTASWGVAISN
                     KLAWILMEAPVFLVMCWMWMHSERRFDPVILTFFIFFQIHYFQRAFVFPLLLTGKSKMP
                     LAIMSMGILFNLLNGYMQGEWIFYLSPEGMYHSGWFTSAWFIAGSLLFFAGMLMNWHSD
                     YIIRHLRKPGDTRHYLPQKGMYRYVTSANYLGEIIEWAGWAILTCSLSGLVFFWWTVAN
                     LVPRANAIWHRYREEFGSEVGGRKRVFPFIY"
     CDS             13160..14383
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Oxidored_FMN"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_11"
                     /sec_met_domain="Oxidored_FMN (E-value: 2.5e-52, bitscore:
                     171.5, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MESKLFTPVTFGPLTLRNRTIRSAAFESMCPGNAPSQMLLDYHRS
                     VAAGGVGMTTVAYAAVTQSGLSFDRQLWLRPEIISGLREVTGAIHTEGAAAGIQIGHCG
                     NMSHKKICGTTPISASTGFNLYSPTFVRGMKKEELPEMARAYGRAVHLAREAGFDAVEV
                     HAGHGYLISQFLSPYTNHRKDEYGGSLENRMRFMEMVMNEVMTAAGSDMAVFVKMNMRD
                     GFKGGMETDETLQVAKRLLALGAHALVLSGGFVSKAPMYVMRGAMPIRSMAYYMDCWWL
                     KYGVRMFGKWMIPTVPFREAYFLEDALKFRAALPEAPLIYVGGLVSREKIDEVLDAGFD
                     AVQMARALLNEPEFVNRMRREERARCNCGHSNYCIGRMYTIEMACHQHLKEKLPPCLQR
                     EIEKLEKQ"
ORIGIN
        1 tatatcaaat cccgtcacct cggcaaagaa tgtgccttga ttaccgacgg acgtttcagt
       61 ggtggaactt ccggattgag tatcggacac gtttctcccg aagccgctgc cggaggtaat
      121 ataggaaaaa tagtagatgg agatatcatc gaaatcgaca ttcccgcccg aacgattaac
      181 gtgcgactaa cagatgaaga actggctgcc cgcccgatga ctcccgtcac ccgtgaccgt
      241 tacgtgccga agagcctgaa agcatacgcc agcatggtaa gctctgccga taagggagca
      301 gtgagattaa tagactgatc cacttcatta tccattatga atcatccatt atccattaaa
      361 gaactatgag taaggactta ataacaggcg cagaggcaat gatgcgctct ctggaacatc
      421 agggagtgac taccattttc ggttatcccg gcggttccat catgcctacg ttcgatgccc
      481 tgtacgacca tcaaaataca ttgaaccata tcttggttcg ccatgaacag ggagctgccc
      541 atgcggcaca aggctacgcc cgtgtatcgg gtaaagtcgg tgtttgcttg gtgacaagcg
      601 gccccggagc aaccaatacg atcacaggta ttgcagatgc gatgatagac agtacgccta
      661 tcgttgtcat tgcaggacag gtgggaacag gcttccttgg aacagacgct tttcaggaag
      721 tcgatctcgt aggtatcact cagccaatcg ctaaatggag ctatcagatt cgccgtgccg
      781 aagacgtagc ctgggcgata gcacgtgctt tctacattgc cagtagtggt cgtcccggtc
      841 cggtggtact cgactttgcc aagaatgcgc aggttgaaaa aacaaaatac gagccgacac
      901 agcaggagtt tatccgcagc tatgttccgg ttcccgacac agacgaagaa tcggtaaagg
      961 ctgccgccga actgatcaat aacgccgaac gcccgcttgt cttggtagga cagggagtgg
     1021 aactgggaag cgctcaggaa gaactgcgta cctttatcga aaaggcggat atgcccgcag
     1081 gttgtacctt gctcggactt tccgcattgc ctaccgaaca tccgttgaat aaaggaatgc
     1141 tgggtatgca cggaaatctg ggaccgaata tcaatactaa caaatgtgat gtattgattg
     1201 ctgtcggtat gcgtttcgac gaccgtgtga cgggtaactt ggctacttat gccaaacaag
     1261 cgaaagtgat ccattttgac attgatccgg cggaagtaaa taagaatgta aaggtagata
     1321 ttgccgtttt gggcgactgc aaaaagacgt tggctgctgt gaccggactg ctgaaaaaga
     1381 accggcacac cgagtgggtc gatagtttca aggaatatga agcggtagag gaagaaaaag
     1441 tcattcgtcc cgaacttcat cctgcaacgg attcactgag catgggcgaa gtggtgcgtg
     1501 cggtaagcga agcgacccgt cacgaagcca tattggtgac agatgtaggt cagaatcaga
     1561 tgatctctgc ccgctacttt aaatatacca aggaacgtag tatcgttact tcgggtggac
     1621 tcggcacgat gggttttggc cttccggcag ctatcggagc aactttcgga cgtcccgacc
     1681 gcacggtatg cgtatttatg ggtgacggcg gactgcaaat gaacattcag gagttgggta
     1741 cgatcatgga acagaaagct ccggtgaaga ttatctgcct gaacaacaat tatctcggca
     1801 acgtgcgcca atggcaggcc atgttcttta atcgccgtta ttcatttact ccgatgctga
     1861 atccggatta catgaagatc gcttccgcct acgatattcc ttccaaacgt gttttttcac
     1921 gggaagaact gaaagcggcc atcgacgaaa tgctctcgac agacgggccg ttcctgctcg
     1981 aagcctgtgt ggtagaagaa ggcaatgtcc tgccgatgac ccctccgggc ggttcagtca
     2041 atcagatgtt gctggaatgt taatccttaa tttagaaagt tatgagtgat aagacattat
     2101 atacgattat agttcattct gaaaatatag ccggattgct gaatcaggtg accgctgtat
     2161 ttacccgtcg gcaaataaac atcgagagtt tgaacgtttc tgcttcttcc attaaaggag
     2221 tacataaata tacgatcaca gcgtggactg ataaagacac tatcgaaaag gtggtgaagc
     2281 agatcgaaaa gaagattgat gtgattcagg cgcactattt tacggaagac gagatttatt
     2341 tccatgagat agccttatat aaggtatcta ctcctgcttt tcaggagact ccggaagcat
     2401 ctaaagtgat ccgcagatat aatgcccgca ttgtagaggt gaatccggta ttctctatcg
     2461 tcgagaagaa cggtatgagt gaagagatta cttcccttta cgaagaactt cgggctttga
     2521 aatgcgttct gcaatttgtc cgttcgggtc gtgtggctat tactaccagc tgcttcgaac
     2581 gtgtgaatga gttcctggac ggacaggagg cgaagtataa gcaaagtaaa aaggaacagg
     2641 agtaatgagt gaagaaaata aaatagggac ttatcagttt gtggcagaac cgttccatgt
     2701 agattttaac gggcgcctga caatgggcgt gctgggaaat catctgctga attgcgcagg
     2761 ttttcatgcc agcgaccgtg gatttggtat tgctacgctg aacgaggaca attacacatg
     2821 ggtgctttcc cgtctggcga tcgagctgga cgagatgcct taccaatacg agaagttctc
     2881 ggttcagaca tgggtagaga atgtctatcg tctgtttacc gaccgtaact ttgctgtcat
     2941 tgacaaggat ggaaagaaga tcggctatgc ccgttccgta tgggcgatga tcaatctgaa
     3001 tacccgtaag cctgccgatc tgttggcatt gcatggagga agcatcgtcg attatatatg
     3061 cgatgaaccc tgcccgatag aaaagccttc gcgcatcaag gtgacaagta atcagcctgt
     3121 tgcgacgctg acggcaaaat atagtgatat cgacatcaac ggacacgtaa acagtatccg
     3181 ttatatcgag cacatacttg acttgttccc gatagaactg tatcagacaa aacgtatccg
     3241 ccggtttgag atggcgtatg tggctgagag ttatttcgga gacgaactct ctttcttctg
     3301 tgatgaggcg aatgaaaatg agtttcatgt agaggtgaag aaaaacggca gcgaggtagt
     3361 atgccgttcc aaggtgatat ttgaataata tagagtataa aatcaattaa taacagatgg
     3421 cgcaagtcat caaaattaaa aaacaaaaaa aatggcacag ttgaattttg gcggaactgt
     3481 agagaatgta gtaatccgtg atgaatttcc attggaaaaa gctcgtgaag tattgaaaaa
     3541 tgaaacaatc gctgtaatcg gttatggcgt acaaggtccc ggacaggctc tgaaccttcg
     3601 tgataacggt ttcaatgtaa tcgttggtca acgccaggga aagacatatg acaaagcggt
     3661 agctgacgga tgggttccgg gtgaaacttt gttcggcatt gaagaagctt gcgagaaagg
     3721 tacgatcgtt atgtgcctgt tgtctgatgc agcagtaatg tctgtatggc ctactatcaa
     3781 gccttacctg actgcaggaa aagctcttta tttctctcat ggttttgcta ttacatggag
     3841 tgaccgcaca ggtgtagttc ctcctgcaga tattgacgta atcatggttg ctcctaaagg
     3901 ttcgggtaca tccttgcgta ccatgttcct tgaaggtcgc ggcttgaact cttcttacgc
     3961 tatctatcag gatgcaacag gcaacgctat ggacagaaca atcgcactgg gtatcggtat
     4021 cggttcaggt tatttgttcg aaacaacttt catccgcgaa gctacttccg acctgacagg
     4081 cgaacgtggt tcactgatgg gagcgatcca gggtttgttg ctggcacaat acgaagtgtt
     4141 gcgtgaaaac ggtcacactc cttccgaagc attcaacgaa actgtagaag aactgactca
     4201 gtcattgatg ccgttgtttg caaagaacgg tatggactgg atgtacgcta actgctctac
     4261 tacagctcaa cgtggtgctc tcgactggat gggccccttc cacgatgcta tcaaaccggt
     4321 agttgaaaag ttgtaccaca gcgtaaagac tggtaacgaa gcacagattt caatcgactc
     4381 taactccaaa ccggattatc gtgagaaact ggaagaagaa ctgaaagcat tgcgcgaaag
     4441 cgaaatgtgg cagactgccg taacagttcg taaacttcgt ccggaaaata actaatcaga
     4501 cttatactat ataagttttt caagaggcgg gaaaatcatc ttttcccgcc tcttctatgt
     4561 gtataccact cttttgaacg acagaataag gatgaaagta gcaaaaaaga ttaaaagaca
     4621 tgggtagtat ggatgaaaaa aagcatttat tgttaccttt gcgtcaacaa ataaaacaga
     4681 atgagcaatg aagacacttt ttactttcag aagatcggta cgtatgcaga tgatttcttc
     4741 tttaataaat agtatatcag aacgttacat caaaagatat ttaagttatt ctctaccgaa
     4801 tggtagaagt aatgccattt caagtccttt taatatttcg tgttccatta gtaattcatg
     4861 ggtatgatgc agaatttcat tctgtagcag gaatgagtat gcgttaaatt gtatttaaga
     4921 cagaactttt ggaacagaat ttagtgggaa aataacattg tttgttttgt ttgtaagtgg
     4981 gagtcctctt tcgtgagaaa gggggcttcc ttgtatttta tcccggcggt tcaggaagat
     5041 accgcttcct gccggatata ctgtatcagt ttccggtaga acgcatgctt ggcaagcgtc
     5101 gttgcatccc ctaaaatcac gagtttcatc cgggcgcggg taatggctac gttcattcgt
     5161 cttaaatcat tcagaaaacc gatctgtccg tcctcgtttg cccggacgag gctgataaag
     5221 acgacatccc gttcctgtcc ctgaaagccg tctaccgtgt tgaccgtgat gaggctgcgg
     5281 aaagggcgga gaaaactgct tcctctgatt ttacttctca gatattgcac ttgcgccttg
     5341 tagggcgaaa tcagaccgaa gtcgatgctc tcgtccagga tgcgtgcttt gccgatccgg
     5401 ttgatatagg cttccagttc ttgcagtaac aagttggctt cctgcttgtt gatgcgcccg
     5461 aagctctcgc ctacaaactc ttcgtggaag tccatttccg aggtatctat ccagttcatg
     5521 ggagtgtcga agtcaaggat accccggttg cgcacttccg gtgcggcttc cagttccccg
     5581 ttgtagaacc attcggaggg aaagcgcatg attgcttcgt gcatccggta ttgcattttg
     5641 agcagcgaga cggcagaagg tttttgctgc acgacctttt ccattagagt gtggtccagt
     5701 ccgccacggg cggcttcgat acatttgatt gtaggaggga gctggcaatg gtcgccggca
     5761 agaatcacac ggtcggcctt tcggatggcg atccaacagg cggcttcgag tgcctgggcg
     5821 gcttcatcga taaataaggt ggggaaacgc cgtccgttga gcaaacggtg attgctgctg
     5881 accagcgtag aagcaatcac acgggcactg tcgaaaagat cggcgttgat caggatttcc
     5941 agttcggtgg cacggtcgcg gaggcggctc atccggctgc gcattccttc cctttcggag
     6001 taacttcccc gacgcatccg gctgcccatt tcacggatcg atttgcggat tccccaaagt
     6061 tcggggtagg caggatgatt ctcaaagcgg cgttcgtagg tgaaagagag cattttgtca
     6121 ttaacacgcg taggattacc aatgcggagc acaggcacac cccggtctac cagtttctcg
     6181 caaatccagt ccacagccgt attactttgg gcgcagacca gcacctgcgg ttcgcggtga
     6241 agcgtttcgt aaatggcttc cacgagcgtg gtagtctttc cggttcccgg aggaccgtgt
     6301 acgatggcga catcgcgtgt gcataacact ttgtttacgg ctgtttcctg cgtgctgttc
     6361 agccacggga aacggacggg atacaattcg cggaatcccg gtttttgtgt tcccagcaag
     6421 gtgtcccgca gttcggcaag gcggttgcct ttggcgcgga tcgtgtcttc cagcgcttcg
     6481 aacatggcac gataggacgt ttcatcgaaa taaagttgta cacccagcac ctcttccgtt
     6541 tgcagttcca gcaatgcacc cgcactggga agcacgacca ccatccgttc atcgtccgca
     6601 taactcaccg atgcaatgaa gttcatataa ttcactttcc cgtcaaatga ctgccggaaa
     6661 aagcagacgg gacgaccgaa ttcgaacgaa tgctcgattt ctttattttc ggtgcgtgta
     6721 atatctatta caagttgatt tagagaattg tagtaacttc gaccgggaga ggcgggatac
     6781 cagcacagac cacgtttcac tttgcgggcg acacccattg tttcagtctg ccgcttgaat
     6841 tcctcctttt cgtgttcata ctccatgcgt agcaggagtt gctgttgctg aaggtcgatg
     6901 attggacttt tcggatgatt attcataata gatgcaaagg tagtaaatct tcctcctgag
     6961 acgaaaatat atttcatttt gttaaacatt cctcgaacgc cgttcgttat ttttatagat
     7021 agactaaaaa aaataaaagc aatatggtgt atgatttgac tatgttagag gctttttatt
     7081 ctgcttataa aggaaaagtg gaacacgtgc gggctgtttt gaaacgccct ttgacgttag
     7141 ccgagaaaat tctgtatgcc catctgttca atgagggcga tctgaaaaac tacaagcggg
     7201 gtgaagacta cgtaaatttc cgtcccgacc gcgtcgctat gcaggacgcg actgcccaga
     7261 tggcattgct tcaattcatg aatgcaggaa aagaaaaagt agctgttccc tccaccgtgc
     7321 actgtgacca cttgatacag gcgtacaaag gagcaaagga ggacatcgct acggcaacca
     7381 aaacaaacga agaagtttac gactttttgc gcgatgtatc ctctcgttac ggcatcggct
     7441 tctggaagcc gggtgccggt atcattcacc aggtagtgct cgaaaactac gctttccccg
     7501 gcggaatgat ggtaggaacc gactctcaca ctccgaatgc cggaggactg ggcatggtgg
     7561 ccatcggtgt cggcggtgcg gatgccgtag acgtgatgac aggtatggaa tgggaactga
     7621 aaatgccaag gattatcggt gtccgcctga ccggaaaact gagcggctgg acttccccga
     7681 aagatgtgat cctgaaactt gcagggattc tgaccgtaaa aggaggaacg aactccatta
     7741 tcgaatattt cggaccggga acagcttccc tgtcggctac cggcaaagcg accatttgca
     7801 atatgggtgc ggaggtagga gctaccactt cgcttttccc gttcgacggg cgcatggcta
     7861 cttatctgag agccaccggc agggatcgta tcgtggaact ggcggaagcc gtggactgtg
     7921 agctccgtgc ggatcaacag gtgacggacg aaccggaaaa gtactacgac cgtgtcatcg
     7981 acatcgattt gtctacgctc gaaccttata tcaacggccc tttcacaccg gatgccgcta
     8041 cccctatctc tgaatttgca gaaaaagtat tactgaacgg ctatccgcgt aagatggaag
     8101 tcggactgat cggttcgtgt accaactcct cttaccaaga tctcagccgt gccgcatccc
     8161 ttgcaaggca ggtgaaggaa aagaatctga gtgtggcttc cccgttgatc atcaatccgg
     8221 gttccgaaca aatccgcgct actgccgaaa gagacggaat gatggatgac ttcatgcaga
     8281 tcggcgccgt gatcatggca aatgcctgcg gcccttgcat cggtcagtgg aaacgtcata
     8341 cggacgaccc gatgcggaag aactcgatcg tcacatcctt caaccgtaac tttgccaaac
     8401 gtgcggacgg caatccgaac acatacgcct ttgttgcttc tcccgaactg acgatggcac
     8461 tgaccattgc cggtgatctt tgcttcaatc cgctgaagga cagactgatg aaccatgacg
     8521 gcgagaaagt gaaactggcc gaaccggtag gagatgaact ccccttgaga ggtttcacct
     8581 ccggcaatga aggctatatc gcccccggcg ggacgaaagc agcgatcaac gtcaacccgg
     8641 cttcccaacg cctgcaactg ctgactcctt tccccgcttg ggacggacaa gatatactca
     8701 atatgcctct gctgattaag gcgcagggca aatgtactac cgaccatatt tcgatggcgg
     8761 gaccgtggct gcgcttccgc ggacatttgg agaatatttc ggataatatg ctgatgggag
     8821 ccgtgaatgc gttcaatggc gaaacgaaca acgtgtggaa ccgttcgaca aacacctacg
     8881 gaaccgtttc gggcacagcc aaaatgtata aatccgaagg aatcccctcc attgtcgtgg
     8941 ccgaagaaaa ctatggagaa ggctccagcc gtgagcacgc ggcaatggaa ccccgtttcc
     9001 tgaatgtgcg tgtgattctc gccaagagct tcgcccgtat ccacgaaacg aatctgaaaa
     9061 agcagggtat gcttgccctt acttttgcgg acaaagcgga ttatgacaag atacaggagc
     9121 acgacctcct ttcagtcatc ggcttgccgg actttgctcc gggacggaat ctgaccgtcg
     9181 ttctccatca tgaagacgga acgaaagaga gttttgaagc gcaacataca tacaacgaac
     9241 agcagattgc ctggttccgt gccggctctg ccttgaatgc cagataatta aaatgataga
     9301 aatgaacaaa ataaccatgc aaaaagatgg tacgctgtcg gtgcctgatg tgcctgtcgt
     9361 accttatatt accggagacg gagtaggagc ggaagtaact ccgtcgatgc aagccgttgt
     9421 gaacgcggct gttcagaaag catacggcgg caaacgccgg attgaatgga aagaagtgct
     9481 ggcgggcgaa cgcgctttca acgagacagg ctcttggctg ccggatgaaa cgatgaaggc
     9541 tttccaagaa tatctgatcg gcatcaaggg gccgctgacg acccctgtcg gcggtggaat
     9601 ccgttctttg aacgtggctt tgcgccaaac tctggatttg tatgtttgtc tgcgtccggt
     9661 ccgttggtat caaggcgttc attctccggt gaaagctccg gaaaaagtga atatgtgcgt
     9721 gttccgtgaa aatacggagg acatatatgc aggaatcgag tgggagtcag gtactcccga
     9781 agccgaaaag ttctatcagt tcctgaaaaa cgagatggga gtgacgaaag tccgcttccc
     9841 cgagacctct tcttttggag tgaaacctgt ttcccgtgag ggcacggaac gtcttgtgcg
     9901 ggctgcctgc cagtatgcgc tcgaccatca tctgccttcc gtgacactgg tgcacaaagg
     9961 aaacattatg aagttcaccg aaggaggctt caagaaatgg ggctatgagt tggcgcaacg
    10021 tgagttcggc gacgcgttgg cagacggccg gctggtgata aaggactgca tcgccgatgc
    10081 tttcctgcaa aatacattac tgattcccga agagtattcc gtgattgcca cgctgaactt
    10141 gaacggagac tacgtttccg accagttggc ggcaatggta ggcggcatcg gcattgctcc
    10201 gggagcaaat attaactaca agacggggca cgccattttt gaagcgactc atggaaccgc
    10261 ccccaacatt gccggaaagg atgtcgtgaa tccttgttct atcattcttt cggcggtgat
    10321 gatgcttgaa tatctgggat ggaaagaagc ggccgcgctt atcgaaaagg cgctggaaca
    10381 gagtttcctc gatgcccgtg ccacgcacga tctggctcgc tttatgccgg gaggtacatc
    10441 cctgtctacc accgctttca cacgcgaaat tgtggaaaga atcgaaaagt aaatgtaacg
    10501 attaaaaacg aagtattatg aagaaagagt atttgattta caagctctcc gaggagatga
    10561 aagaggcaac ccggattgac aatgaattgt tccccaagtt tgacgtgaag cgtggactac
    10621 gtaatgaaga cggcaccggt gtattggtag gtctgacaaa gattggtaat gtggtgggtt
    10681 acgaacgtat ccccggcggc ggtctgaagc ctattccggg aaaattgttc tatcggggct
    10741 atgatgtgga agacatttcc cacgccatca tcaaggaaaa acgtttcggc ttcgaagaag
    10801 tggcttatct gctactctcc ggtcgcctgc cggacaagga agaactggct tcgttccgcg
    10861 aactgatcaa tgacaatatg gcgctcgagc agaagacgaa aatgaatatt atcgagctgg
    10921 agggaaataa tatcatgaat atcctttcgc gcagcgtact cgaaatgtat cgtttcgatc
    10981 ccgatgccga cgatacttcc cgcgacaatc tgatgcgcca gagtatcgat cttatctcca
    11041 agttcccgac catcattgcg tatgcttata atatgctccg ccatgctaca ttcggccgtt
    11101 ccctgcatat ccgtcatccg caggaaaaac tctctattgc cgagaatttc ctctatatgc
    11161 tcaaaaaaga ttatacggaa ctggatgccc gtacgctcga cttgctattg attttgcagg
    11221 cagaacatgg cggtggtaac aactcgactt tcacggttcg tgtgacttct tccaccggaa
    11281 cagatacata ttcggccatc gccgcaggta tcggttcgtt gaaaggcccg cttcacggag
    11341 gcgcgaatat ccaggtggcc gatatgttcc atcacttgca ggagaacatc aaggactgga
    11401 agagcgtgga cgagatagat acctatttca cacggatgct gaataaggaa gtgtataata
    11461 agaccggact gatttacggt atcggtcatg ctgtttatac gatttccgat cctcgtgcgc
    11521 tgttgctgaa agaactggct cgcgaccttg cccgtgagaa aggaaaagaa gaggagttcg
    11581 ctttcctcga actgcttgaa gagcgtgcca tcgctacttt cggacgtgtg aagaacaacg
    11641 gaaagacggt ttccagcaat atcgacttct attcgggctt cgtatatgag atgattggtt
    11701 tgccgcagga gattttcact ccgctgtttg ccatggctcg tattgttggc tggtgtgcgc
    11761 accgcaatga agaactgaac ttcgagggca aacgcattat ccgtccggct tataaaaatg
    11821 ttcttgatga tctggcttat atccccatca agaaacgctg ataagaacaa atccttttat
    11881 gcaataataa ctaacctcag acgtacatct cggcaatccc tgcatgtacg tctcggtaat
    11941 ccccagttgt acatcttggt agtacccggt tgtacgtctg gggtgacttg tttcaggaag
    12001 aacgtccgat gttcatttaa catttaacac tttgcggctg ctatattttt catccgatgg
    12061 aggctaaggc atttatcgtt ggtagaaagg gcacagcctg gcaggtagaa acgccctttt
    12121 aacgctacgt taaaagggcg tttctacaac cgatgaatta tacattctat ttctttggat
    12181 atcagtgaac tatgtgctaa aagcccatgg tgtcatatga aagagaacac gggatggaaa
    12241 aaaagataat tgtgatattc ataagtttcc tgtccggtca atacgaatag ttctttcagt
    12301 tttttgtggc catttttttc tttttttgtt atttttgtga atctcaaaag aaaatcaaga
    12361 tgagtataac tgcctttaat ctatttttgg gcgtcatgag tctgatcgct ctgattgttt
    12421 tcatcgccct ctactttgtg aaagccggtt acgggatatt tcgcactgcc tcctggggag
    12481 tcgccatttc caacaagctg gcgtggatac tgatggaagc ccccgtattt ctggttatgt
    12541 gctggatgtg gatgcactcg gaacgtcgtt ttgatccggt catactgaca ttctttatct
    12601 tctttcagat tcattatttt cagcgcgcct tcgtctttcc cctgctactg accggaaaga
    12661 gcaaaatgcc gctggcaatt atgtcgatgg gaatcctgtt caatctattg aacggctata
    12721 tgcagggcga atggatattt tatctctcac ccgagggaat gtatcattcc ggctggttca
    12781 cttccgcatg gtttattgcg ggcagtctgc ttttctttgc aggtatgttg atgaactggc
    12841 attcggacta tatcatccgt catttgcgca aaccggggga tacccgtcat tatctgcccc
    12901 aaaaagggat gtaccgctat gttacttccg ccaattatct gggcgaaatc atcgaatggg
    12961 caggctgggc aatactgacc tgttcactgt ccggacttgt attcttctgg tggacagtgg
    13021 ccaatctcgt cccccgtgcc aatgcaatct ggcatcgcta ccgtgaagaa tttggctcgg
    13081 aagtaggcgg acgcaaacgt gtatttcctt ttatctattg atttgaaata aattatctat
    13141 tgacataaaa tagcgtacta tggaatctaa acttttcacc cctgtcactt tcggtccatt
    13201 gacgctgcgg aatcgtacga tccgctctgc cgcttttgaa agtatgtgtc ccggtaacgc
    13261 cccttcacaa atgctgctcg attaccaccg ctcggtggct gcgggcggag tcgggatgac
    13321 gactgtagcc tatgcagccg tgacgcaaag cggactttct ttcgaccgtc agttgtggct
    13381 gcgtccggaa atcatttccg gtttacgtga agtgaccgga gctatacaca cggaaggtgc
    13441 ggcagcaggc atccagatag ggcactgcgg aaatatgtcc cataaaaaga tttgcggaac
    13501 cactcccatt tcggcctcta ccggtttcaa tctctattct cctacattcg tgcgtggcat
    13561 gaagaaagaa gagttgccgg agatggccag agcctacgga cgggctgtcc acttggcacg
    13621 ggaagccggc ttcgacgccg tggaggtgca tgccggacac ggatatctga tcagccagtt
    13681 cctgtctccc tacaccaatc accggaaaga cgaatacggc ggctcgctcg aaaatcggat
    13741 gcgctttatg gaaatggtga tgaacgaggt gatgacagca gcgggaagcg atatggcggt
    13801 ctttgtaaaa atgaatatgc gcgatggctt caaaggtggc atggaaaccg atgaaaccct
    13861 gcaagtggcc aaacgcctgc tggcattggg cgcgcacgca ttggtactga gcggaggctt
    13921 cgtcagcaag gccccgatgt acgtcatgcg gggagcgatg ccgattcgtt cgatggctta
    13981 ctacatggac tgctggtggc tgaaatacgg ggttcggatg tttggaaagt ggatgattcc
    14041 gaccgttcct ttccgggaag cctatttcct ggaggatgca ttgaaatttc gggcggcact
    14101 tccggaagcc ccgttgattt atgtgggcgg actggtgtcc cgcgaaaaga tagacgaagt
    14161 attggatgcc ggcttcgatg ccgtccagat ggcacgtgcg ttgctcaacg aaccggagtt
    14221 tgtcaaccgg atgaggcggg aagagcgggc acgttgtaac tgcgggcaca gcaactactg
    14281 catcgggcgc atgtacacta ttgaaatggc ctgccaccaa catctgaaag aaaaactgcc
    14341 tccctgcctg caacgggaga ttgaaaaact ggaaaagcaa tgagtgaaga gaaatgggca
    14401 atcatcaccg gtgccgacgg cggcatggga acggaaataa cccgtgccgt agccgaagcc
    14461 ggttaccata ttattatggc ttgctatcgt ccgtc
//
