LOCUS       c00146_gnlPro..        17476 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LKPIEHCK_146.
ACCESSION   c00146_gnlPro..
VERSION     c00146_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 13:40:34
            Original ID  :: gnl|Prokka|LKPIEHCK_146
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 17476
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..17476
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[4505:7476]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      4506..7476
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..17476
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..17476
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="1"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             34..366
                     /locus_tag="ctg146_1"
                     /transl_table=11
                     /translation="MKREIIAYKGYFKEFFENLDAGTQDKILYVLMLLQTQDRIPLKFM
                     RLIEEGLYELRIEYQSNIYRIFFCFDEGRIVILFNGFQKKTEKTPKKEIDKAKILRKEY
                     YGSKNK"
     CDS             complement(722..2488)
                     /locus_tag="ctg146_2"
                     /transl_table=11
                     /translation="MGVKIIVRACHPDETLPETLQEIEDFHHAAYTRLVSFYTELCQIE
                     IDTSGQDVARTCLFSYDPEIYFNPNADAFLVDQPQASYKVSNRKNLSGSKQQTPPDGPP
                     TNEDTALNAHSANASLVLTLTYYHNKSEKYIAGNRNNYLHHLSCTFNRYGIPQEEASAF
                     IKSQFTDFPADETVSLINSAYAHTDEFNTCKLNGTQKRILRIEQYISEHYETRYNEVLH
                     IMEYRRRHPDTEKPEPFRILDEMMENSIWIEINELGYPCTVKTIENLIYSDFSQSYHPI
                     REYFELLPEWDGTDYIRILADSVQTSHQEFWAECLERYLVAMCAAATQENIVNHTVLLL
                     CSEIQNIGKTTFINNLLPPELRAYLSTGLINSNNKDDLAKITQAMLINLDEFEGMSGRE
                     LNAFKDLVTRKVISFRLPYARRSQNFPHTASFAGTCNYQEVLHDTTGNRRFLCFHPYSI
                     QFITINYAQLYAQIKYLLNKPGYQYWFTQADNERLEENNEAFIFHSPEEEMVLTHIRKP
                     ERFEKVYYLTVSEIAELIRERTGYQYSIGSKIQLGKVMTKHHFESKKGNNGRRYAVFII
                     DIEQVKSNRLYE"
     CDS             complement(2682..3080)
                     /locus_tag="ctg146_3"
                     /transl_table=11
                     /translation="MSASKLLYKYFVVGLFTTSLSCTNSNRKATAHATVSFRRNKWQLS
                     YTFWANRSNLLPFYTKFLYTFPQRSSFASTNNNQNKNETFHHISRFLLRNSRDDRRRNS
                     VHYRQFYLPGKSRRNTPHLCRARRKGCQ"
     CDS             3347..3850
                     /locus_tag="ctg146_4"
                     /transl_table=11
                     /translation="MAMTVSYSVVPRKNPAKKSEPAKYYAQAQASGELDFEELCEAITS
                     RSTCTETDVRAAISGILYEVKRALKAGRIARLGDLGSLQIGLNSEGAASVKEFSGSMIK
                     GAHLIFRPGKTLAELMKILSYQQVQTRAVAQAGAGDGGGEDPDKNPDSGGDGSGDEEAP
                     DPTV"
     CDS             3910..4077
                     /locus_tag="ctg146_5"
                     /transl_table=11
                     /translation="MKEIVNRILDVIMYLIPFFGKRKRDRVVREVRYHTTCKEVCKVKT
                     TEREKEHEKD"
     CDS             4217..4513
                     /locus_tag="ctg146_6"
                     /transl_table=11
                     /translation="MRDEDTVGAHARGYNAISLGVCYEGGLDENGKAADTRTPRQKEAL
                     HRLVHELLQRYPEAKVVGHRDLSPDTNYNGIVDPWERIKECPCFEVIGEFSIN"
     CDS             complement(4506..5234)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 72.5;
                     E-value: 1.4e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg146_7"
                     /sec_met_domain="Radical_SAM (E-value: 5.7e-29, bitscore:
                     92.6, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMINVHSYESMGTFDGPGLRLVVFLQGCNFRCLYCANPDTIAGKG
                     GTPTPPEEIVRMAMSQRPFFGKRGGITFSGGEPTFQAKALVPLVRELKEKGIHVCLDSN
                     GGLWNEDVEELFRLTDLVLLDIKEFNPNRHQTLTGRSNEQTIRTAAWLEEQEKPFWLRY
                     VLVPGYSDFEEDIRALGEALGKYKMIQRVEILPYHTLGVHKYEAMGQEYKMKGVKENTP
                     EQLEKAAEVFKEYFTTVVVN"
     CDS             complement(5248..7476)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg146_8"
                     /sec_met_domain="Gly_radical (E-value: 1.9e-46, bitscore:
                     148.1, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate1 (E-value: 0.0, bitscore:
                     1173.8, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELNKIFKDGLWSSEINVRDFVSHNITPYYGDASFLEGPTERTKA
                     VWNRCLEALAEERENNGVRSLDNVTVSTITSHKAGYIDKENELIVGLQTDELLKRAIKP
                     FGGINVVSKACHENGVEVDDRVKDIFTHYRKTHNDGVFDVYTEEIRSFRSLGFLTGLPD
                     NYARGRIIGDYRRMALYGIDRLIEAKKEDLHNLTGPMTEARIRLREEVAEQIKALKDMK
                     VMGEYYGLDLSRPAYTAQEAVQWVYMAYLAAVKEQDGAAMSLGNVSSFLDIYLEYELSK
                     GTITESFAQELIDQFVIKLRMVRHLRMQSYNDIFAGDPTWVTESLGGRLNDGRTKVTKT
                     SFRFLQTLYNLGPSPEPNLTVLWSPELPEGFKEFCAKVSIDTSSIQYENDDLMREVRQS
                     DDYGIACCVSYQEIGKQIQFFGARCNLAKALLLAINGGRCENTGTVMVKNIPVLTSDTL
                     KFEEVMDNYKKVLTEIARVYNEAMNIIHYMHDKYYYEKAQMALVDTNPRINLAYGVAGL
                     SIALDSLSAIKYAKVTARRNDIGLTEGFDIEGEFPCFGNDNDKVDHLGVDLVYFFSEEL
                     KKLPVYKNARPTLSLLTITSNVMYGKKTGATPDGRAKGVAFAPGANPMHGRDKNGAIAS
                     LSSVAKLRYRDSQDGISNTFSIVPKSLGATDEDRIENLVTMMDGYFTKGAHHLNVNVLN
                     RDMLYDAMEHPENYPQLTIRVSGYAVNFVKLSREHQLEVISRSFHERM"
     CDS             8302..9333
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1058:Major
                     facilitator family (Score: 75.4; E-value: 1.3e-23)"
                     /gene_kind="transport"
                     /locus_tag="ctg146_9"
                     /sec_met_domain="MFS_1 (E-value: 6.6e-24, bitscore: 75.4,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LFAGVYVDRWNRKKTMFYSDLFIAFCTLCLFIVITKGYKDLSFFY
                     LLTACRSIGSTFHAPALQASIPLLVPKHHLVRVSGLYHSIQSFSEVIAPVVGASLVVWL
                     PIQYILLIDVIGAVAACLTLLCVQIPSLQKTKVLPDFKKELTECWHTLRRTMGILPLFV
                     CFTLVTFVLMPVFTLFPFMTLLHFNGNILQMGVVEMGWGSGALLGGLVLACKALKSKQT
                     LVMHTAYVILGLYLISASYLPSSAFIGFVCLTFTGGIAYSIYHALFIAIIQQNLASDML
                     GRTFSLIFSLSTFPSMLGIVASGYWVEAWGITSVFMISGWVIFLIGVGANFISSIKQLD
                     NYA"
     CDS             9358..9870
                     /locus_tag="ctg146_10"
                     /transl_table=11
                     /translation="MTKKEHTTITELFQVLDLLESLDMQFWLDGGWGVDVLYGQQTRLH
                     RDIDIDFDANYTDQLLDLLQERGYQIETNWLPTRVELYSKELGYIDIHPFVLNADGTSK
                     QADLDGGWYEFQPDYFGTAVFEGRSIPCISAKGQQVFHSGYDLREKDIHDLSIIKQCIT
                     TMSLTIR"
     CDS             10054..10245
                     /locus_tag="ctg146_11"
                     /transl_table=11
                     /translation="LGYGTAVVLGHKEYYPRFGYRKAIDLGIEFPFEVSHEYCMVAELI
                     PGATENVKGMVCYPTDFK"
     CDS             10401..10538
                     /locus_tag="ctg146_12"
                     /transl_table=11
                     /translation="MKKSASTKSKRVFPFHDSPFAIFKNIFHHTNHFSSGKFIHKHFVD
                     "
     CDS             complement(10759..12162)
                     /locus_tag="ctg146_13"
                     /transl_table=11
                     /translation="MATKSSIHIKPCNIASSEAHNRRTAEYMRNIGESRIYVVPELSTD
                     NEQWINPDFGTPELRTHYDNIKQMVKEKTGRAMQEKERERKGKNGKIIKVAGCSPIREG
                     VLLIRPDTTLADVRKFGEECQRRWGITPLQIFLHKDEGHWLNGQPEAEDKESFQVGNRW
                     FKPNYHAHVVFDWMNHETGKSRKLNDEDMATMQTLASDILLMERGQAKAVTGKEHLERN
                     DFIIEKQKAELQRIEETKRHKEQQVSLAEQELKQVKAEIRTDKLKKTATNAATAIASGV
                     GSLFGSGKLKELEHHIEQLHQEITKRDKATDELKIQIQQIQEQHSRQIRNLQRIHNQEL
                     EAKDKEISRLSTLLEKAHKWFPMFKEMLRMEKLCAVIGFTKDMIENLLTKKESIQCSGK
                     IYSEEHRWKFDIKNDIFRVEKHPMDSGKLMLTINRQPIVQWFKEQWEKLQQNLRNSVQR
                     EQKSRGFRI"
     CDS             complement(12374..12739)
                     /locus_tag="ctg146_14"
                     /transl_table=11
                     /translation="MDYLSFLTLRLESCPQSPDFDRQDYIVLNSVANVPKALYPLGSYE
                     RIHCFFDNDRAGMEAIQQIRKEYDATRYIRDASQIYSGCKDLNEYLQKRIADRKEQAQS
                     VEKRNDTLSKKPKGFRL"
     CDS             complement(12712..12846)
                     /locus_tag="ctg146_15"
                     /transl_table=11
                     /translation="MKFATDISRDVSHQKKYPISDSQENQGVHVTFLRDLWITFPFLL"
     CDS             complement(13550..14641)
                     /locus_tag="ctg146_16"
                     /transl_table=11
                     /translation="MGGMLMDYMKEIKEISAEQAIILWQASRLSLSKIYEKAPEILKVQ
                     GSVIGTLGNFSASIGKAKSKKTFNVSAIVAAALKNGTVLRYVAELPEEKRKILYVDTEQ
                     SHYHCLKVMKRILRLAGLPDDRDNEHLEFLALRKYTPEQRIRIVEQAIYNTPDIGLVII
                     DGIRDMVYDINSPGESTRIISKLMQWTDDRQIHIHTILHQNKGDENARGHIGTELNNKA
                     ETVLLVEKDKSNGDISNVSAMHIRAMDFEPFAFRINDNALPELIEGYRPEAKKPGRPEE
                     EKFDPYRHISEQQHRIALEAAFGLKEEYGYKDLETSLIKSYMSVGVKLNHQKAVSLITM
                     LRNKRMIVQENGRKYTFKPDFHY"
     CDS             complement(14641..14907)
                     /locus_tag="ctg146_17"
                     /transl_table=11
                     /translation="MTGEEFIFLSKHASGQAEALPQPVTDTEKKYVYGILGIAKLFGCS
                     LPTANRIKKSGKIDKAITQIGRKIIVDAELALELAGKKTGGRK"
     CDS             complement(15173..16225)
                     /locus_tag="ctg146_18"
                     /transl_table=11
                     /translation="LTRTRTHNIKYMAGKIQTMIPQYGELNRIYRDYIDNYAFSFDRQK
                     FISDFYQEYNDMKSFEAAILELVLDKQKEQYTLILNSLKTEIEKSIQAYEIRPLSDRAI
                     ERACYQHMERYSQEIEAQLDVTRSLSKPLNEANNRYDSIGYREHTAEEEKQAEKEYERC
                     KAEYDREKAKLNKLYDQQKAARTEAFQYMKNCCADIYRQSCLFLDILKKYIPDGKQENK
                     SSEPISQQETTEEQQEYFSMKLLSLIHEVCIGEQFEEISALDFYANMNLHPCNCKLKIK
                     PREKIRVCYLIFLMSEKLSKQDRDKWKDRILKLLDIDDSYYKSKYKEPVSDFPSDSNQN
                     FAKEMEHIFR"
     CDS             complement(16203..17228)
                     /locus_tag="ctg146_19"
                     /transl_table=11
                     /translation="MCQFARLYPLNVLRSFIEADSILSVPNIQNITNEVLKLNSGQFTQ
                     ELTAQIQSADNQSLEITQEVPAQFQNVAKTVATIYKIKIEDIEDLFLASPIARINWASH
                     MVILNNPLPLGVRYWYMKQSVEMGWSSNVLKMQIESNLYDRQIKSNKVNNFTATLPAPQ
                     SDLANYLLKDPYIFDLAGAKEKADERDIEEQLVKHVTRYLLEMGNGFAFVARQKHFQIG
                     DSDFFADLILYNIKLHAYVVVELKATPFKPEYAGQLNFYINVVDDKLRGENDNKTIGLL
                     LCRGKDEVVAQYALAGYDQPIGISDYQLSKAVPENLKSALPSIEEVEEELTLFLDKDKN
                     P"
ORIGIN
        1 gtatagttga acaacatttc ttatatttgc gttatgaaaa gagaaataat agcatataaa
       61 ggatacttca aagaattctt tgaaaattta gatgctggca cccaagataa gatattgtat
      121 gtgctaatgt tattgcagac acaagacaga atacctttga aatttatgcg gttgatagaa
      181 gaaggacttt atgaacttcg tatcgagtac caaagcaata tatatagaat attcttttgt
      241 ttcgacgaag ggcgtattgt gattctgttt aacggttttc aaaagaaaac cgaaaaaaca
      301 ccaaagaaag aaattgataa agcaaagata ttaagaaagg agtattatgg aagcaaaaac
      361 aaatgaggaa ttctttaatg tcagtgcatt aatagatgag cgttttggta aggaaggaac
      421 agcttctcgt gcagaggcag aagaaaaggc ctacgccttt tatacaggac agattatcga
      481 ggacgcaaga aaaaaggcta aaatcactca ggctgaatta gcccggcgta tcggttctga
      541 ccgttcttat atttcaagag tagaaagtgg tcagacagag cctaaagtat ctactttcta
      601 tcgtataatg aatgcgttag gctgtaaaat cgaattttca atgattttgt aaaaacaata
      661 aatgcagagt atctgtcaag atgactctgc attttgctat attcacaagg ctttcccgct
      721 tctattcata cagcctgttt gattttacct gctcgatatc tataataaat acggcatatc
      781 ggcgcccgtt atttcctttt ttagattcaa aatggtgctt agtcatcacc ttccccaact
      841 gtatttttga tccgatggaa tactgataac cggtacgctc acgtattagt tccgcaatct
      901 cactgacagt cagataataa accttctcga aacgttccgg cttgcggata tgcgtaagaa
      961 ccatttcttc ttccggtgaa tgaaagatga aagcctcgtt attctcttca agccgttcat
     1021 tgtccgcttg cgtgaaccag tattgatatc ccggcttatt cagcagatat ttgatctgag
     1081 catagagctg cgcataattg atggtaataa attggatgga ataaggatga aaacaaagga
     1141 aacgccggtt gcctgtcgtg tcgtgaagca cttcctgata attgcaggtt cctgcaaaag
     1201 aggccgtatg agggaagttt tgcgaacggc gtgcataagg cagacggaaa ctgatcactt
     1261 tgcgcgttac caaatctttg aatgcattca gttcccggcc gctcatccct tcaaactcgt
     1321 cgagattgat cagcatggcc tgcgttattt tggctaaatc atctttattg ttcgaattga
     1381 ttagtccggt agagagataa gcacgcagtt cgggaggcag gagattattg ataaaggtag
     1441 tctttcctat gttctgtatc tcgctgcata gcagaagtac cgtgtgattg acaatattct
     1501 cctgagtagc cgctgcgcac atcgccacca gataacgttc caggcattcc gcccaaaact
     1561 cctgatgact cgtctggaca ctatccgcca ggatacggat ataatcggtt ccgtcccatt
     1621 cgggcagtaa ttcaaaatac tcgcgaatgg gatgatacga ctggctgaaa tcggagtaaa
     1681 tcagattttc gattgttttg acagtgcagg gatatcccag ttcgttgatt tctatccaga
     1741 tactgttttc catcatctca tccaagatgc ggaaaggctc cggtttctcg gtgtcgggat
     1801 gccttctgcg atattccatg atatgcagca cttcgttgta gcgtgtttcg tagtgctcgc
     1861 tgatatattg ctctatccgt aatattcgtt tctgcgtgcc attcagttta caggtattaa
     1921 attcgtcggt atgagcgtag gcgctattga tcaaagagac tgtctcgtct gccggaaagt
     1981 ctgtaaactg gcttttgata aaagcggatg cttcctcctg cggaatgccg tagcgattga
     2041 aggtacatga gagatggtgc agataattgt tccggttgcc tgctatgtat ttttcggact
     2101 tgttgtgata gtaggttaaa gtcagcacca gagaagcgtt ggcggaatgg gcgttgagcg
     2161 ctgtgtcttc attcgtcggg gggccgtccg gaggagtctg ttgtttactg ccggagagat
     2221 ttttacgatt tgaaaccttg taggatgcct gaggttgatc tacaagaaaa gcgtcagcgt
     2281 tcggattgaa ataaatctcc ggatcgtaag agaacagaca agtgcgtgct acatcctggc
     2341 cggaggtgtc gatttctatc tgacagagtt cggtgtaaaa agaaacgagt ctggtgtaag
     2401 ctgcatgatg gaagtcttct atttcctgaa gggtttcggg caatgtctca tccggatggc
     2461 atgcgcgtac tatgattttc acgcccatcc ctttgggact gataaaggcg atgcgggtgt
     2521 aattgcatct cttgatgata gggaggatgc gtgccaattc ttctttgctg aggtggtcga
     2581 tgtctatcac gatgtgtccc agatatttga cgaggttcac tttggtacgc cttcctcggt
     2641 agctggcgga gaaggcgatt gccggcaatt cttttttctt ctcattggca gccttttctc
     2701 cttgctctgc aaagatgcgg cgtatttctt cgactttttc ccggtaggta aaactgccga
     2761 tagtggacac tatttcttct tcggtcatct ctgctattgc gtagtagaaa ccttgaaata
     2821 tggtgaaatg tttcattttt attttgatta ttgtttgtcg atgcaaagga acttctttgc
     2881 ggaaatgtgt aaaggaactt tgtataaaat ggcaataagt tactacggtt cgcccaaaaa
     2941 gtgtatgata gttgccactt gtttcggcga aaggagacgg ttgcgtgcgc ggtagccttc
     3001 ctgttcgagt tcgtgcagga gagggaggtt gtaaataatc caacgacgaa gtatttgtaa
     3061 agcaactttg aggcagacat ggggattgta aaggtgagcc agttccgctt tggtataggt
     3121 gcggataagg aaagaatctt ctttgtaatt catgatgttt tcttcttgtt ttatgctata
     3181 aagttacata aaattccttg tttttcaaag gtttgacttc gtttttattc gttgggaatc
     3241 aagaaacttc gttggggaat atagcttgtc cggctatcct tatctttgtg ctgttaacaa
     3301 gaaggggatg catcctatgt attataaact ttaaaattat tttattatgg caatgacagt
     3361 atcttattca gtggtgccgc gcaagaatcc tgcaaaaaag agcgaaccgg caaagtatta
     3421 tgcacaggcg caggcgtcgg gtgagctgga ctttgaagag ttgtgcgaag cgatcaccag
     3481 tcgttctact tgtacggaaa cggatgtacg tgcggctatt tcgggtattc tttacgaagt
     3541 gaaacgtgcg ttgaaggcag gaagaattgc gagactgggc gatttgggca gtttgcagat
     3601 aggactcaac agtgaaggtg cggcatcggt caaggaattt tccggttcaa tgattaaggg
     3661 ggcgcatctt attttccgcc ccggtaagac gctggcggag ttgatgaaga ttctgagtta
     3721 tcagcaagtg cagactcgtg cggtggcgca ggcgggtgca ggcgatggcg ggggagaaga
     3781 ccctgacaag aatccggatt ccggtggtga tggctccggt gatgaagagg ctccggaccc
     3841 tacggtataa ttggcagacg ggtcaaggta ataacgaatt agaataactt ccattaatat
     3901 tttgataaga tgaaagaaat agtaaaccgg attttagatg tgatcatgta tctgattcct
     3961 ttcttcggaa agagaaagcg ggacagggtg gtgagagaag tgcgctatca tactacttgt
     4021 aaggaggtgt gcaaagtgaa aacgacggaa agggaaaagg aacatgagaa agattagtct
     4081 gattgtgatc cattgttccg ccacccgtgt cgattgcgac tttacggcaa aggatgtgga
     4141 tacggctcac cgttatcgtg gcttttcgtg ctgggggtat cattattata tatgcaagtc
     4201 gggcgagatt gagccgatgc gggatgaaga tacggtcgga gctcatgcac gtggctataa
     4261 tgcgatcagc ttaggtgtat gttatgaggg cggtcttgat gagaatggaa aagctgcgga
     4321 tacgcgtaca ccccgtcaga aggaggcgct acatcgcttg gtacacgaat tgttgcagcg
     4381 ttatccggaa gctaaagtag tagggcatcg ggatttaagt cccgacacca actataatgg
     4441 gatcgtagat ccttgggaac ggattaaaga atgtccttgc tttgaggtca ttggagaatt
     4501 ctccattaat taactaccac cgtagtgaaa tactctttga atacctccgc agctttttca
     4561 agctgttcgg gggtattttc ttttacccct ttcatcttgt attcctgtcc catcgcttcg
     4621 tacttatgta cgcccagtgt atggtaaggc aatatttcca cccgttggat catcttgtat
     4681 tttccgagtg cttctcccag tgcgcgtatg tcttcttcaa aatcgctgta tccgggcact
     4741 agcacgtagc gtagccagaa aggtttctcc tgttcttcca gccaggcggc cgtgcggatg
     4801 gtttgctcgt tgcttcttcc ggtgagcgtc tgatggcggt tagggttgaa ttcctttata
     4861 tccaataaca caagatcggt cagtctgaat aattcttcta cgtcttcgtt ccaaagtcct
     4921 ccgttgctgt ccagacagac atggatgcct ttttctttca gttcgcggac cagcgggacg
     4981 agtgctttcg cctgaaacgt cggttcgcct ccggagaaag tgattccccc tcgtttcccg
     5041 aagaaggggc gctggctcat tgccatgcgg acgatttctt ccggtggggt aggcgtgcct
     5101 ccctttcctg ctatcgtatc cggattggcg caatagaggc agcggaagtt gcatccttga
     5161 agaaaaacga cgagccgtaa gcccggcccg tcgaatgttc ccatactttc gtatgaatgt
     5221 acgtttatca tcatatagag taatagatta catacgttcg tggaagctac ggctgataac
     5281 ttccagttgg tgttcgcggc tcagcttcac gaagtttacg gcatagccgg aaacgcggat
     5341 agtcagctgc ggatagtttt ccggatgctc catggcatcg tacagcatat cacggttcag
     5401 tacgtttacg ttcaggtggt gggcaccttt ggtgaagtaa ccgtccatca tcgtcacgag
     5461 gttctcgata cggtcttcgt ccgtagcacc cagtgatttc ggaacgatag agaaggtgtt
     5521 gctgataccg tcctgtgagt cacggtaacg aagtttcgct acagaactca gagaagcgat
     5581 cgcaccattc ttgtcgcgtc cgtgcatcgg attggcaccc ggagcgaagg caacaccttt
     5641 ggcacgtccg tcgggagtag caccggtctt tttgccgtac atcacattgg aagtgatagt
     5701 cagcaaggag agggtaggac gggcattctt gtaaacaggc aatttcttca attcttcgct
     5761 gaagaagtat accaggtcta cgccaaggtg gtctaccttg tcgttgtcgt taccgaagca
     5821 agggaattct ccttcgatgt cgaagccttc tgtcagaccg atatcattgc ggcgggcagt
     5881 tactttcgca tatttgatgg cagacagtga atcgagggcg atggaaagtc cggctacacc
     5941 gtaagccagg ttgatgcgcg ggttcgtatc tacaagagcc atctgggcct tctcgtagta
     6001 atacttgtcg tgcatatagt ggatgatgtt catcgcttcg ttatatacgc gggcgatttc
     6061 ggtcagcact tttttgtagt tgtccattac ttcttcgaac ttcagcgtgt cactggtcag
     6121 tacggggata ttcttcacca tgactgtacc ggtattctcg caacgtccgc cgttgatggc
     6181 aagcaacagg gctttggcca ggttgcaacg ggcgccgaag aactgaatct gcttacctat
     6241 ttcctggtat gatacgcagc aggcgattcc gtagtcgtcg gactgacgta cttcgcgcat
     6301 caggtcgtca ttttcgtact ggatagaaga agtgtcgata gaaacctttg cacagaattc
     6361 tttgaatcct tccggaagtt ccgggctcca gagtacggtc aggttcggtt ccggtgaagg
     6421 gccgaggttg tacaatgtct gcaggaaacg gaaggaggtc tttgtcactt tggtacgtcc
     6481 gtcgttgaga cgtccgccca gagattcggt tacccaggtc gggtcgcctg caaagatgtc
     6541 gttgtatgat tgcatacgca ggtggcggac catacgcagt ttgatgacaa actggtcgat
     6601 cagctcttgc gcgaatgatt cggtgatggt tcctttgctc agttcatatt ccagatagat
     6661 atcgaggaaa gaagaaacgt tacccagtga catggcggca ccgtcttgtt ctttgacggc
     6721 ggcaaggtaa gccatatata cccactgtac ggcttcttgt gccgtgtaag cgggacggct
     6781 caggtcgaga ccgtagtatt cgcccatcac tttcatgtct ttcagtgcct tgatctgttc
     6841 tgccacttct tcgcgcaggc ggatgcgggc ctctgtcatc ggaccggtga ggttgtgcaa
     6901 atcttccttc tttgcttcga tcagacggtc gatgccgtaa agagccatac ggcggtagtc
     6961 accgatgatg cgtccgcgtg cataattgtc gggaagtccg gtaaggaatc ccagcgaacg
     7021 gaaggaacgg atttcttccg tatatacgtc gaatactccg tcgttgtgcg tcttgcggta
     7081 gtgagtgaaa atatctttta cgcggtcgtc cacttccacg ccgttttcgt gacaggcttt
     7141 gctgactaca ttgatacctc cgaaaggctt gatggcacgt ttcagaagtt cgtctgtctg
     7201 caggccgacg atcagttcgt tttccttgtc gatatatccg gccttgtggg aagtgatggt
     7261 tgatacggta acattatcta atgagcggac accgttgttt tctctttctt ctgccagtgc
     7321 ttcgaggcag cggttccata cggctttggt acgttctgta ggtccttcga ggaatgaagc
     7381 atctccgtaa tacggagtga tgttatgact tacgaaatct ctgacgttga tttcgctgct
     7441 ccaaagaccg tctttaaaga tcttgtttaa ttccataaaa tgataaaatt agaggttgta
     7501 gttatcctat tctttagagc gcacaaagtt acaatcattt ttcatataat cagcataaat
     7561 atgctctatt ttatgctttt caacataaaa tacctattaa ttgctatcct taggaaaaga
     7621 ttagattaaa tttttagtga aaactcttgc aagtttaaaa tatcttcgta cctttgcacc
     7681 gcttttaacg aaaagcactt ctgataagga agttttggag aggtggcaga gtggtcgatt
     7741 gcggcggtct tgaaaaccgt tgtaccgcga ggtacccggg gttcgaatcc ctgtctctcc
     7801 gcaacaaacg ctgaaaatca gcagattgca aaacaaacac ccagttttac acccaagaat
     7861 gtaaagtcgg tgtttttgtt ttatttaaga taatacaacc actacataat aaaagagtag
     7921 cgatattaaa agaatccgat gagaaaagac taatatttat ctatccattc agtttgattt
     7981 ttcaggactt tacatcgtcc tgaaagtatt tgttattgta ttccaacgtc aggagtggat
     8041 tataatacaa gttttttgtg tggatagaat ttcgttttgc ttaatgtacg aaagtactta
     8101 tctataaacg catgaaatat tagcacaatg aatcattgga aatcaacttt ggccgtgata
     8161 ggaataggcc aactcatatc tattttaaca agtacgattg ttggcttctc cattattttt
     8221 tggattagca acgaatttaa atccccgaca gctttatctc tggctatttt agctggattt
     8281 ttaccacaat ttgtattagg cttgtttgcc ggggtctatg ttgacagatg gaatcgaaag
     8341 aaaacgatgt tttattcgga cttgttcatc gcgttctgta ccctatgtct ttttattgtg
     8401 ataaccaagg gttataaaga cctttctttt ttttatctat tgactgcttg tcgttcaata
     8461 ggcagtacgt ttcatgcacc tgctttacag gcaagcatcc ctctactggt tcccaagcac
     8521 catcttgtca gggtatcagg tttgtaccat tccattcaat ccttcagtga ggtgatagct
     8581 cccgttgtag gggcaagcct cgttgtttgg cttcccatac agtatattct gctcatagat
     8641 gtgatcggag ctgttgctgc ttgtctgacc ttactttgtg tccagattcc ttctcttcaa
     8701 aaaacgaaag ttcttccaga tttcaaaaaa gaactgacgg aatgttggca taccttgcgg
     8761 cgtacaatgg gcattttgcc tttattcgta tgctttacgc tggtgacttt tgtccttatg
     8821 cctgttttta cgttatttcc ttttatgacg cttctgcatt tcaacggaaa cattttgcaa
     8881 atgggagttg tggaaatggg ttggggctca ggggcattgt tgggcggttt agtacttgcc
     8941 tgtaaggctt tgaaaagcaa gcaaacatta gtgatgcata cggcttatgt gatattggga
     9001 ttgtatctga ttagcgccag ttatttacca tcaagcgcat ttataggttt tgtttgccta
     9061 acatttacag gaggcatagc ctattccatt taccatgcgc ttttcatcgc tattattcag
     9121 cagaacttgg cttcggacat gcttggacgg actttttctc tcatctttag tttgagtacc
     9181 tttccatcaa tgctgggtat cgtagcttca ggatattggg tggaagcatg gggtatcaca
     9241 tccgtcttta tgatcagcgg atgggttatc tttctgattg gagtgggtgc aaattttatt
     9301 tcttcaatca agcagttgga taattacgca tagtattatt tattaaagaa ttattatatg
     9361 acaaagaaag aacacactac gattacagag ttatttcaag ttttggactt gttggaaagc
     9421 ctggacatgc agttttggtt ggatggaggc tggggagtgg atgtcttgta cggacagcaa
     9481 acccgcttgc atagagatat tgacattgat tttgatgcca attatacaga ccaactcctt
     9541 gatcttttgc aggagagagg atatcaaatt gaaacaaatt ggttgcccac ccgtgtggaa
     9601 ctgtatagca aagaattagg ctatattgat atccatcctt ttgtcttgaa tgcggacggc
     9661 acttccaaac aagccgactt ggatggaggc tggtatgaat ttcaaccgga ctattttgga
     9721 acagcagtct ttgaaggcag aagcatccct tgcatttctg caaaagggca acaagtattc
     9781 cattcgggct acgatttaag agagaaggat attcacgatt tatctataat taaacaatgt
     9841 ataacaacaa tgagcctaac aattagataa gaacaagaaa atgacagaaa aacaaattgt
     9901 ctggtatatc ttacttacag aagtaaagat agacagtgac acccagtctg tcacatccct
     9961 gagtgtagct ccattggcag tcttgccgga attccagcgt aagggaattg gggggggatg
    10021 ttgattcagt aagcccatca gagggcagca cttttgggtt acggcacagc agtcgtattg
    10081 gggcataaag agtattatcc tcgatttggc tatcgcaagg ctatcgattt aggaattgaa
    10141 tttcctttcg aagtctctca tgaatattgc atggtggctg aattaatacc tggagctact
    10201 gagaatgtga aaggtatggt ttgttatcca actgacttta aatagtttaa caagtaaaat
    10261 tcattatata actcggactg ggtatttcaa tttcccagtc cgtattctga tagtacttat
    10321 tcaattggaa gattgtgttg cttcaagaat gaaagtttat cccaataccc tctttgaaag
    10381 acgattttgt tatcttttac atgaaaaaat ccgcatccac gaagtccaag agagtctttc
    10441 cattccatga tagcccattc gccatcttca aaaatatttt ccaccataca aaccatttta
    10501 gcagtggcaa attcattcac aaacattttg tagattgatt ctttacctat tattggttcg
    10561 tttgcgactt gatgatttac tgcattagta gcatacagct ctgctatatg ataagcatct
    10621 gctttgttaa agcaatctat ccatttttcc aaaacttctt taggcttcat tttttataaa
    10681 ttcttaggat tttgattctg taataaaaac aatctgtttg gatgcataga tacttgattt
    10741 tattaataat aggctattct atattctaaa tcctctggat ttttgctctc tctgcaccga
    10801 gttacgtaga ttctgctgta acttttccca ttgttcctta aaccattgta ctatgggttg
    10861 tcggtttatg gtcagcataa gcttaccact atccatcgga tgtttctcaa ccctaaaaat
    10921 atcattcttg atgtcaaatt tccacctgtg ttcttcggaa taaattttgc cactacattg
    10981 tatggattct ttctttgtca agaggttttc tatcatgtct ttggtaaacc cgataacagc
    11041 gcataatttt tccattctca acatctcttt gaacatggga aaccatttgt gggctttttc
    11101 aagcaaggtg ctcaatcgtg atatttcctt gtctttggct tcaagttctt gattatgtat
    11161 tctttgaaga ttacgaattt gtctgctatg ctgttcctgt atttgttgta tctgaatttt
    11221 taattcatca gtagctttgt cccgtttggt aatttcctga tgtagctgct cgatgtgatg
    11281 ttccagttct ttcagcttac cgcttccgaa aagagaacct acaccgcttg ctatggcggt
    11341 agcagcattg gtggctgttt tctttagttt gtccgtgcgt atctctgctt ttacctgttt
    11401 gagttcctgt tcggcaaggc ttacttgttg ttccttgtgt cgcttggttt cctctatacg
    11461 ttgcagttcg gctttctgct tctcaatgat gaaatcattt cgttccagat gctctttacc
    11521 tgtgacagct tttgcctgtc cacgttccat caggagaata tcggaagcaa gggtctgcat
    11581 ggttgccata tcctcgtcat tgagctttcg gctctttcca gtttcatggt tcatccagtc
    11641 gaatacgaca tgagcatgat aatttggttt gaaccatctg ttaccgactt ggaagctctc
    11701 cttgtcttct gcttccggct gaccgttcag ccaatgccct tcgtctttat gcaggaaaat
    11761 ctgtagcgga gtgatgcccc agcgtctttg gcactcttca ccgaatttgc gtacatcagc
    11821 cagtgtggtg tccggtctga taagcaatac tccttcacgg atgggtgagc atcccgccac
    11881 cttgataatc tttccattct ttcccttgcg ttccctttcc ttttcctgca tggcacgtcc
    11941 ggtcttttcc ttgaccattt gcttgatatt gtcataatga gttcgcagtt cgggagtgcc
    12001 gaagtcggga tttatccact gttcgttatc ggtggaaagt tcgggaacga catagattct
    12061 ggactccccg atattacgca tatactcggc agtccttcgg ttgtgtgcct cgctcgatgc
    12121 gatgttgcaa ggcttgatat gtatgcttga ttttgttgcc atagcttctt tcctttgttt
    12181 acaattgatt tactttgctc gctttcgcag aggggttctt aggggtaacc cataagcgga
    12241 gattgcaaag agagggtcac tctttgctcg gggttctcag gggtgaaacg ccctgagtgg
    12301 gtcattaggg caaagcccta atcccctcgg gagagcccac aactacgcaa gcgaagcgtg
    12361 tagttatagt gggctataac cggaagcctt tcggtttctt ggatagcgta tcattcctct
    12421 tttcgacaga ttgcgcttgc tctttcctat cggctattcg tttctgtaaa tattcgttca
    12481 gatctttaca tccactgtag atttgcgagg cgtcacgtat ataccgggta gcatcatact
    12541 cctttcggat ttgctgtatt gcttccattc ctgcacggtc attgtcaaag aaacagtgga
    12601 tgcgctcata gcttcccaac ggatagagtg ccttgggaac attggctacg gaattaagaa
    12661 ctatgtaatc ctgtctgtcg aagtcgggtg attgcggaca gctttccagc cttaaagtaa
    12721 gaaaggaaag gtaatccata aatccctcaa aaacgtaaca tgtactcctt ggttttcctg
    12781 actgtctgat atgggatatt tcttttggtg cgatacatcc cttgaaatat cggttgcgaa
    12841 tttcatatcc gcctgatatg ttcggaaagg caatggcgaa ataccgtttg ccgttgtggg
    12901 tgaaacgggc ttccttacat tctcttttcg ccagtgccgt gtttatccct ctttcctgta
    12961 ggtaggcaag cagggcagga gaagccagca gcacaatgtc caattgctga aaactcggtt
    13021 cggaaaatga ttgcttgcca aaagagaaag acacgggacg tatgtgtggt atctgttctt
    13081 cgattttctg tagaagataa ggcacatagt cggaacagta gagttcctgt gccagtgcga
    13141 tgatatttcc acctttgccg attgcgaaat cataccattg gttgcgctcg gtatttactt
    13201 tgaacgaggg ttctgtctct tcccgtaacg gggatttgta ccataggtta ataccttgct
    13261 gcttgacggg agaatatccc aaactgtaca gaaaatccgc tatcctgatt tgttttgctg
    13321 tctgtatatc cataataaga tgagtgtttg aataatggtt ggaatattta tttctctttt
    13381 cgcccgtact tttttatgaa gtacggtctg tataatcact tcactttatc ttcgtatata
    13441 taggatacgg taataaagtg aagcgctttt ctattcccta caaccgcttc gctttattct
    13501 taatatatag acctgccgaa taaagtgaag tgattacagg ttatacggtc taatagtgaa
    13561 agtccggctt gaacgtgtat ttcctgccgt tctcctgtac tatcatccgt ttgttccgga
    13621 gcatggtgat aagtgatacc gctttttgat ggttcagttt tacacctacc gacatatatg
    13681 acttgattaa ggaggtttcc agatccttgt agccgtattc ctctttcagt ccgaaagccg
    13741 cttccagtgc tatgcggtgc tgctgttcgc taatatgtct gtaagggtca aacttttcct
    13801 cttccggtct tccgggtttc ttcgcttcgg gtctgtaccc ctctatgagt tcaggcaatg
    13861 cattgtcgtt gatacggaaa gcgaaaggct cgaaatccat tgcacggatg tgcatggctg
    13921 aaacattgct tatatccccg ttgctcttgt ccttttccac cagcagaacg gtttccgcct
    13981 tgttgttcag ctccgtaccg atatgccctc ttgcgttttc atcgcctttg ttctggtgga
    14041 gtatcgtatg gatgtgtatc tgcctgtcat ccgtccactg catcagtttg gatataatgc
    14101 gtgtcgattc tcccggactg ttgatgtcat ataccatatc acggatgccg tctatgatta
    14161 caagccctat gtccggtgta ttatagatag cctgttcgac aatcctgata cgctgttcgg
    14221 gcgtgtattt cctcaaagcg agaaactcca gatgttcatt gtccctgtca tcaggaagac
    14281 cagcaagccg taaaatacgt ttcatgactt tcagacagtg ataatggctt tgttccgtgt
    14341 ccacataaag aatcttcctt ttttcttccg gtagttccgc aacataccgc agtaccgtac
    14401 cgtttttcaa tgcggcggct acgatagccg atacattgaa agtcttttta ctcttggctt
    14461 tgccgatgga tgcactgaaa ttgcccagtg taccaatgac cgaaccttgc acttttagaa
    14521 tctcaggtgc tttttcgtag attttcgaca gactcaggcg tgaagcttgc caaaggatta
    14581 ttgcctgttc tgccgaaatc tcctttattt ctttcatata gtccataagc atacctccca
    14641 ttatttccgt cctcctgttt tcttcccggc aagctcaaga gccaattccg catctacgat
    14701 aatcttgcgc cctatctggg taatcgcctt gtctatctta ccgcttttct ttatgcggtt
    14761 ggcagtgggc agactgcacc cgaacagttt ggctataccg agtattccgt acacatactt
    14821 cttttccgtg tctgtaacgg gttgcggcaa tgcttcggcc tgacctgaag cgtgcttact
    14881 caggaatatg aattcttcgc ctgtcatctg ccagacgggt tttgataata attcttggat
    14941 atttgtcatc gtccaatcta tttagtcgtt aaacaatcag ccctgcgcac tggctgttat
    15001 ttctgttctc gaacgatgca aaattaggta gggttatgag tggtaaggat ggggacggta
    15061 caaactgaat atcattgtat cttattgaat atcagaaaat aaaaatacca ctcaaaaatt
    15121 attttgagtg gtaaaagtgg aactttcgta aagtatcagg atatattacg gattatctga
    15181 atatatgttc catttccttg gcgaaatttt ggttgctgtc actggggaaa tctgaaacag
    15241 gctccttgta cttggatttg tagtagctgt cgtcaatatc cagcagtttc agtattctgt
    15301 ctttccattt gtccctgtcc tgtttggaga gtttctcgct catcaggaat atcagatagc
    15361 atacacgtat tttctctctc ggttttattt tcagcttaca gttgcagggg tgaagattca
    15421 tattggcata gaaatccagt gcggaaattt cttcgaactg ttctcctatg cacacctcat
    15481 gaatgagcga aagtaatttc atgctgaaat attcctgttg ttcttctgtc gtttcctgct
    15541 gactgattgg ctcgcttgat ttattctctt gctttccgtc aggaatgtat ttcttcaata
    15601 tatccagaaa aaggcagctt tgacggtata tgtccgcaca acagttcttc atgtattgga
    15661 atgcctctgt tcttgcagcc ttttgctgat catagagttt gttcagtttg gctttttccc
    15721 tgtcatattc agccttgcag cgttcatatt ctttctctgc ctgtttttcc tcttcggctg
    15781 tatgctccct gtaaccaatg gaatcatacc tgttgttggc ttcattcagc ggcttgctca
    15841 gacttcttgt aacatccagc tgggcttcaa tttcctgaga atacctttcc atgtgctgat
    15901 agcaagcacg ttctatggct ctgtcactta acgggcgtat ctcataagcc tgtatgctct
    15961 tttctatttc agttttcagg ctgttgagta tcaaggtgta ttgctctttt tgcttgtcaa
    16021 gcaccagttc aaggatagcg gcttcaaagg atttcatgtc attatactcc tgatagaaat
    16081 ccgatatgaa tttctgcctg tcaaaagaaa aagcgtaatt atctatatag tctctgtata
    16141 ttctgttgag ttctccatat tggggaatca tcgtctgtat ctttcctgcc atatacttta
    16201 tattatgggt tcttgtcctt gtcaaggaat aaggtcagtt cttcttccac ttcttctata
    16261 ctcggtaggg cagatttcag attttcgggt actgccttgc tcaattgata gtcgctgata
    16321 cctatcggct ggtcatatcc agccaaggca tattgtgcca cgacctcatc cttacccctg
    16381 cacagcaaaa gaccgatggt cttgttatca ttttctcccc tcagtttatc atctacaaca
    16441 ttgatataga aatttaactg ccctgcatat tccggtttga atggcgttgc tttcaattcc
    16501 acgacaacat aggcatggag cttgatatta tataggatca ggtcggcgaa aaagtcactg
    16561 tccccaatct ggaaatgttt ttgtctggca acaaaagcaa agccgttacc catttccagc
    16621 aagtaacggg ttacatgctt taccaactgt tcttctatat ccctttcgtc agccttttcc
    16681 tttgctcctg ccaagtcaaa gatatacggg tcttttaaca gataattggc aagatcgctt
    16741 tgaggtgccg gaagtgtggc agtgaagttg tttaccttgt tactcttgat ttgtctgtca
    16801 tacagattac tttcaatctg cattttcagc acattactgc tccaacccat ttctacagat
    16861 tgtttcatat accaatacct tacgcccaat ggtagcggat tattgagtat gaccatatgg
    16921 cttgcccaat ttattcttgc aatcggtgac gccaagaata aatcttctat atcctctatt
    16981 tttattttat agatggttgc tactgttttt gctacattct gaaattgcgc aggaacctcc
    17041 tgcgtaattt ctaaagattg attatcagct gattgtattt gcgcagtaag ctcctgcgta
    17101 aattgtccgc tattgagctt aaggacttca ttagtaatgt tttgaatatt tgggaccgac
    17161 agtattgaat ctgcttcaat aaaactacga agtacattta acggatataa acgggcaaac
    17221 tggcacatat aagtaagatt acgttccgaa tatcccttct tttcaggata attgaatctg
    17281 attgcctgtg ccaatttttt gataatttta ccaccccacc catgtaggtg ttggtggtac
    17341 agtatataat tccccatttt ccagtaatgg aacaacatct gggcattggc tgcggtaatg
    17401 agtcggactt gtgcctgttc tatttccgaa ccgacagcat ggacaaaggc atcaaaatga
    17461 cctttcttta tattat
//
