LOCUS       gnlProkkaFOIMAHGM_53   10628 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FOIMAHGM_53.
ACCESSION   gnlProkkaFOIMAHGM_53
VERSION     gnlProkkaFOIMAHGM_53
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 11:28:44
            Original ID  :: gnl|Prokka|FOIMAHGM_53
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10628
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10628
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[1314:5628]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1315..5628
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..10628
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10628
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             103..1251
                     /locus_tag="ctg53_1"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             1315..2034
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 54.5; E-value:
                     1.6e-16)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_2"
                     /sec_met_domain="NTP_transf_3 (E-value: 2.4e-16, bitscore:
                     50.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CDIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             2055..3356
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_3"
                     /sec_met_domain="CTP_transf_like (E-value: 2.9e-13,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 3e-121, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 3.4e-63, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             3373..4497
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_4"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.6e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.4e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             4507..5628
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg53_5_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_5"
                     /sec_met_domain="Aminotran_5 (E-value: 2.3e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        4597..5604
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg53_5_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg53_5_Aminotran_5.1"
                     /locus_tag="ctg53_5"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             5625..5768
                     /locus_tag="ctg53_6"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             5971..7455
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg53_7"
                     /sec_met_domain="Polysacc_synt (E-value: 2e-31, bitscore:
                     99.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKQKTVSGIMWSAIERFSLQGVQFIIQIILARLLLPSDYGMI
                     GMLAIFLQVAQVFIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIA
                     DFYNMPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWM
                     AYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLIN
                     TVYRNLYTIVIGKKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCL
                     TNAYRNYIRLSSYIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQ
                     INLNLLWVKGRSDLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYY
                     TNSLIDLTLKLQVKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCITGMSFYILLS
                     FLFKLDSFFCILTLIIKTKNIDENIKKDFSSNSKDN"
     CDS             7409..8668
                     /locus_tag="ctg53_8"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLVNKPVIF
                     NFYDIEEYRRVRGFSFEPIEFFCAGDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLM
                     NQFQDDNSTKRICDIFLNEI"
     CDS             8677..9426
                     /locus_tag="ctg53_9"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKNSK"
     CDS             9426..10466
                     /locus_tag="ctg53_10"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEII
                     YPDFIE"
ORIGIN
        1 aagggaacat agctaatatt ttaggttatg ctacttcctt cagttctttg ggaatgatga
       61 ttgcttctat tgctaatttg ataaagaaat aaatgaccta ttatgattga aaagcaatct
      121 tatcaagaac cgttttctga agtggataaa aggaaagatg atgaaatgga aatagacttg
      181 atggctattt tttataagat tattactgtt cgtggagtac tatgcaaagc tgctggagtg
      241 ggagtaataa ttgctatagt ggtggcattg agcattccca agcaatatac agtaaaggtt
      301 accctttctc ctgaaatggg taatgcgaag ggaagtaatg gtttagccgg acttgctgcc
      361 tcgtttttgg gagatggggc tctaataggg gaaagcacag atgccttgaa cgcttctctt
      421 tcagcagata ttgtttcttc aactcctttt ttattggaac ttttagaaat ggaagtctcc
      481 gtttctaaaa aggatgataa aatgactttg gggtcttatc tcgatgaaga gtcatctcct
      541 tggtgggatt atcttatagg ttttccgggc atagtaatag gaggagttaa atcattattc
      601 ggagaagata cggttcctgc cagtggaggg cggcaaggaa ctatcgaatt gacgaaagaa
      661 gtaaatgaga agattaattt tcttaaaaag aagattagtg catccattga taagaaaacc
      721 gccataacga gcattacggt caccttacaa aatccgcaga tcactgcggt tatagcagat
      781 tctgtcgttc ataaattaca ggaatatatt attgggtatc gaacttcaaa agtaaaagaa
      841 gactgtgcgt atttggaacg gttgtttaaa gaacgtcagc aggaatatta tgctgctcaa
      901 agaaaatatg cggattatgt agacgcccat gataatgtgg ttcttcaaag tgtacgtgct
      961 gagcaggagc gtttacagaa cgacatgagt ttggcttatc agatatatag tcaggttgct
     1021 aatcagttgc aggtatccag agccaaagta caggaggaaa agccagtctt tgcagtagtt
     1081 gagcctgccg ttgtaccttt gaaaccttca ggtatgggac tcaaaattta tattttatta
     1141 tttgtgttcc tgtccgtatc tggtactctc gtgtgggtgt tttttggcaa aagtctgctg
     1201 gctagcttga gaaaagaact gaaaaataag gagatagaac aggataaatg atgctaaaac
     1261 gtcgtttaca acattcttac atcaattaaa ttcacttact atattattaa acgaatgata
     1321 cgtacagcta tgataatggc tgcgggcatg ggaacccgtt ttggccaata tacagaattg
     1381 atacctaaag ggttcgtcaa agtgggaggt attccaatga tagttcgttc tattgatact
     1441 ttgttatcat gtgacattga gcgaattgta atcggtacag gatataaaca agaagtttat
     1501 gaagaattga agacagacta tcctatgctt gaaacctgtt ttagtcctcg ttatgctgaa
     1561 acaaatagta tgtatacttt atataatacg cgggagattc tgggcaatga tgatttttta
     1621 ttgttagagt cagatttgat ttttgagaaa caagcaataa tgagcttatt ggagtgtcct
     1681 gcggcagatg caatgctaat aactccagtg acaaagtttc aagatcagta ttatgtggaa
     1741 catgatgata attttcgcct ttcttcatgt tctgtcaata agaataaact aaacgctaaa
     1801 ggcgaattgg tcggcatcca taaactatcc ggttcctttt acaaaataat gtgtgctgat
     1861 tatgcgagta ttgttgatga acaacccaat ttgggatatg agtatgaatt actacgaata
     1921 tcttgttctc aatctcctgt ttatgtgcat aaagtagaag ggctgaaatg gtatgaaatc
     1981 gatgacatat cagatttgga atatgcagag aaatatattg ttccgtattg ttaattaaaa
     2041 taatatatca aattatgagt aagacagttt atattgggat gactgcggat attatgcatc
     2101 caggacttat ccgcattatt aatgaggcta ctaaatacgg tgatgttata attggtcttc
     2161 ttacagataa agctattgcg gagcataaac gccttcctta tctgacctat gaacaacgaa
     2221 aagaggtagt tcagaatatt aaaggcgtat gtaaagttgt tcctcaagaa gaatggagct
     2281 atgttgagaa tctcaaacgc attaaacctg actatataat tcatggtgac gactggaaaa
     2341 ccgggccttt acgtgaagaa cgtgtgcgcg tatttgaagt gatgaatgaa cagggaggaa
     2401 aggttatcga aattccatat actttgggaa ttaattcatc ttctttggat aaagatatta
     2461 aggctatagg tacaacccct gatgtacgtt taaaatcact tcgtcgtttg ataaatgcca
     2521 aacccgtagt tcgtattttg gaagctcatg atggactatg tggcttgata attgaaaatc
     2581 aggaaatatt aaaaggggat aagagggaag tatttgacgg aatgtggtct agtagcctta
     2641 cggattcaac cagtaaaggt aaacctgata ttgaggcggt tgatttaact acccgattgc
     2701 aagatttgaa taatattctg gagtgtacta ctaaacctat tatttttgat ggagatacag
     2761 gtggtaaaat tgaacatttc gtatttacag tacgcacttt agaacgtcat ggaatttcag
     2821 ctataataat tgaagataaa gttggattaa aaaagaattc attgtttggt acagatgtta
     2881 ttcaaactca agatacaatc gaaggtttct gtaataagat caaagcagga aaggcatctc
     2941 agattactga tgattttatg attatcgctc gtattgagag ccttatagcg ggaaagccgg
     3001 taagtgatgc tttagagaga gcttttgcat atgtccaagc gggagcggac ggtattatga
     3061 tacatagcaa aaataagtcg ggtgaagata taaaagaatt ttgtttggcg tttcgaaaac
     3121 agtatgctca tgtacctatc gtggttgtgc ctactacata tgatcatatt tatgagtctg
     3181 aattgtgtga ttggggtgtg aatataatta tttatgctaa tcatatgctt cgtgccgctt
     3241 atcctgctat gatgaatgtc gcaaagataa tattagagaa tgaacgtgct ttagaggtgc
     3301 gcgaactgtg tatgcccata aaagaaatat tggaactgat tccaggtact aaataaaaag
     3361 aggaatatca ttatgttaag cgtagaaaaa gtttatgaaa cgtttctgag tcatgacgtt
     3421 gattttttta caggagttcc agactcatta ctaaaaaata tttgtgccta tatcacagac
     3481 catacttcac gtgagaaaca tatcatagct gctaatgaag gtgcggctgt aggaattgct
     3541 tcaggttatt atatggcatc aggtaaggtt cctgtggttt atatgcaaaa ttccggcttg
     3601 ggtaatactg ttaatcctct gctgtctctt gcagatgaac aagtatacag ttttccaatg
     3661 cttttgatga ttggctggcg tggtgaaccg ggaacaaaag atgaacctca gcataaaaaa
     3721 cagggtgagg taactttaga tttgttgaaa gcaatgcgga ttccttatat aattcttgat
     3781 tcaaatgaga atgatgcatt tattcagctc catgatatca tacaatcagc aaaaactaag
     3841 aatattcctc atgcaataat tattcggaaa gatgtttttg gcaaatataa acttcaaaaa
     3901 gagttcggat gtaattatcc tttatctcgt gaggatgctt tgcaaatagt tgtggattat
     3961 ctgcctgaaa attcagtggt cgtttctact actggcaagc tttctcgtga gttatttgaa
     4021 tatcgagaaa tgaaagagca aggtcatgaa catgattttc tcacggtagg ctctatggga
     4081 catagttcat caatctcttt gggtattgct atagcaaagc aagatagacc tgtttattgc
     4141 ttggatggtg atggagcatt tattatgcat ttaggggcaa ttagtaacat tggcgattta
     4201 tctcctaaaa actattatca tattttgttt aacaatggtg ctcacgagtc tgtaggagga
     4261 cagcctactt taggatttag tttagatatt ccggctattg tccgggggag cggatataag
     4321 catacttata ctgtttgtac aaaagttgaa attgaagaag caatgaagca gcttccaaag
     4381 ttatgtggtc ctgttttgtt ggaaataaag gttaaaatag attctcggga gaatttggga
     4441 cgtcccacga ctactcctat agagaataag gagcatttta tggatttttt aaaataaata
     4501 tattcgatga aaatagaaag aaaaatatta ttaaatcctg ggcctgccac tactactgac
     4561 agtgtaaaaa tggcacaagt tgttccggat atttgtcctc gcgagaaaga attcgcaggt
     4621 atgatgaaac aacttcggga cgatttggtc agagttgctc atgggaattt ggaaaaacat
     4681 accgctgtat tattttgtgg ctcaggaacc atcaatattg atatatgtct aaattctctt
     4741 cttcctgaag acaaaagggt gcttatagtg aataatgggg catatagtac ccgtgctgta
     4801 gaagtgtgtc aatattatgg tttgcctcat attaatttgg aattttccgt ttacgaacgt
     4861 cctgatttat cggtggtgga aaatgtgttg caagaaaatc ctgatatagc tatggtttat
     4921 actactcatc acgagacggg tacaggaatt ctgaacccta ttcgcgagat gggcgctata
     4981 gctcataaat atcaggctaa atttgtcgtc gatactactt cttctttggg catgattcct
     5041 tttgatatag agaaagataa tgtggatttt tgtatggcat ctgctcaaaa aggacttcaa
     5101 gcgatgacag gtctttcttt tattataggc aatgaggaac agattaagtt ttcaaaaaaa
     5161 tatcccaagc gttcttacta ttgtaatctt tatttgcagt atgagaattt tgagagaaca
     5221 ggtgaaatgc attttactcc accggtacaa actatttacg ccactcgtca ggcattaaat
     5281 gaatattttg aagtgggtga agaagctaag tttgcccgtc acaaaagagt ttttgaggct
     5341 attcattcag gtataaatga aattggtctt aaaagtgtaa taaagcgtga atggcagtca
     5401 ggactggttg tctcagttca atacccagaa gatcccaact gggattttga gaaaatacat
     5461 gattattgtt atgagcgtgg atttacgatt tatccaggta agatatcaac tgaggatact
     5521 tttagaatct gtgctttagg agagatagaa gtagatgata ttgagaactt ctttaaagta
     5581 ctaaaagctg cattaaatca ttataacgtc acattaccga tgtcatgatt gcagaaatat
     5641 tattgaagat tcgtcatttt tatttttccc ttcgtggtat acacttccat ccggaaagtg
     5701 ttatttctgg agtgcctatt cgtagctttc gcttagtagg caaatatggc aatattaatt
     5761 tgaggtgatg cattaggagt tctttattct tataaaaagg catcggtagt tataggagat
     5821 aatgtttgtg tagggtaatt tgcttttagt gggagagacc atattagaat tgcggtaagg
     5881 ggcgaagaag ataataacca attagtgaga atattggaaa aatataattg atatcggtaa
     5941 atgtagttgt ttttatactg tatttaagta atggaaaatc taaagcagaa aactgtatca
     6001 ggaataatgt ggagcgctat agaacgtttc tctttacaag gagtacagtt tataattcaa
     6061 ataatattag ctcgtttgtt actaccatcg gattatggta tgatcgggat gttagctatt
     6121 tttcttcaag tcgctcaagt atttatagat agcggtttta caaatgcttt aatccagaaa
     6181 aaagatagaa ctgaagagga ttttgccact gtcttttatt ttaatattct tgtcgcagta
     6241 ttattctatg gtatattgtt tttttcggct tctttgattg cagactttta taatatgccg
     6301 actttagttc ttgtaattcg ttttatagca ttgtcgttga taataaatgc tttatcggct
     6361 attcacagaa cgaaattaat tatttctgta aactttaaaa ctcaatctaa aatttcatta
     6421 ggtgcagctt ttatatcagg cgtgattgga atatggatgg cttatgtcgg ttgcggggtt
     6481 tgggctttag tttggcaaac tctcttaaat agtataattt tgacaatttt gttttactgt
     6541 ttagttcatt ggaaaccttt acatactttc tccaaaagtt cttttgaaag attattcaat
     6601 ttcggatcta aattattgat ctcaagtctt atcaatacag tatatcgtaa tctgtatacc
     6661 attgtaatag gaaaaaagtt ttctgttgta gagcttggtt actatacaag agcagaacaa
     6721 tttgctattt ttccttccaa taatttaaat gctttagttt ctagagtagc gtatcctatt
     6781 ttaagttcca ttcaagatga tgataaatgt ttaacaaacg catatcgaaa ttatatcaga
     6841 ttatcctcat atataatttt tcctttaatg gtaggtttac ttgttttggc taatcctatt
     6901 attagtctat tgttaacaga taaatggtct ggggttgtta ttcttttaca gatattatgt
     6961 ttggattgga tgtttgatca tttgagccaa attaatttga atttattatg ggttaaagga
     7021 agatctgatc tgtcgttacg tcttgaaata ataaaaaaga cgattgctat attcattctt
     7081 tttgtgtcaa ttccatttgg gcttgaggtg atgtgttggg gtagagttat ttactctctg
     7141 atagcgacat atttgaatac atattatact aattctctta ttgatttgac cttaaagttg
     7201 caagttaaag atgtatttcc aagtttaata ctctctttca taatgggggg gatcgttttt
     7261 atatgtattt ctttctttga aactgatata gtaaaaattg tgattggatg tattactggg
     7321 atgtccttct atattttact ttcttttctt tttaagctag attctttttt ttgtatttta
     7381 acattgatca ttaaaactaa aaacatagat gaaaatatta aaaaagattt ttcaagtaat
     7441 agtaaagata attaaccatt gtgtgccagt tgatagtaga tcattgtatt ttattcctca
     7501 tcctaattgt agaacagata aatatgatat tataaattat tcgtcagata atgttctcgt
     7561 tctgttaaat tatttgctaa aaaaagatag tgctgaatat tataaaatat atgttgaaat
     7621 ttatgattct tctcgtattt cagaatatca agaatatatt tatggcataa atcctaatat
     7681 taggtgtact tttttatgtg catgtgttgg acgttttttc tttaataaag tatcttttaa
     7741 ggatatgttg tatgcctttt tttgtttttg tagagcaagt aaatgtttta cagctacttt
     7801 ttattatgat ttttcattta aaaaacgctc tcaacagatt atttgtttgg ggtattatac
     7861 tccattcaaa gatgattatc atatgggaga tcattcttat gataaatttc gtaatacaac
     7921 atgtaactca tttgattact ctattgctac ttcttgttta agtgctagaa taatttcaat
     7981 agattgtgga atctcatatg ataaattcaa agtcttagga tttcccagaa atgatttgtt
     8041 gatatcgaaa aataattgca atgttattaa aagagaaatt tcgaaatttg cgggatatga
     8101 tgtaactaaa tatatagttt atactccaac ttttcgtgat tatgagactg ttactgaagg
     8161 taatttgcgt tcaatactcg gatatgttga ttgtgatttg ttgaagttat cgaaaatact
     8221 attgaagttt aatgcggctt taattcttaa attacatcct ttgcagaata aaacagtctt
     8281 aaaaaaagat ttacccaaag gtatacttgt ttttgaacaa acatataaat atggattgta
     8341 tgatcttttg tcattttcag atggaatgat tactgattat acttctacct attttgattt
     8401 tttattggta aataagccag tcatatttaa tttctacgat attgaagaat atcgtagagt
     8461 aagaggtttc tcatttgagc caatagaatt tttttgtgca ggtgatattg tttacaatta
     8521 taatgaattg atagatgctg tgatgggact tctggctggg aaagatattc atgctgaaca
     8581 tcgacgtcat atttctttat tgatgaatca atttcaagat gataattcaa caaagagaat
     8641 atgtgacata tttttaaatg aaatataata aataaaatga attatgcatt tgtggtgcag
     8701 gcacgtttag gttctacacg tttgcctgga aaaatattga aacctttcta tggtaatcaa
     8761 tcgattcttg acttaatggt tcataagctt tctgctatat cgaatattcc agtaattatt
     8821 gctacaacaa attctgttat caatgaacct attgaaaaga aggcacttgc attaggggta
     8881 aagtgcttca gaggtgagga gaatgatgtt ttaaaacgat tcattgatgt tgctgaatat
     8941 tttgatatac agggtatatt ccgaatatgt tctgataatc catttttaga tgtacatgcg
     9001 gcaaggcaat tggtcgaaat agcaatgaaa tcttgtaacg attatataag ttttgatatt
     9061 gatggtactc catcaattaa aactcatttc ggtttttggg gagaatttgt aacgcttgat
     9121 gcgctgaagc gagttatagg atttactgat gatttattgt atcgtgaaca tgttactaat
     9181 tatatatata gtcatcctga actttttaat attcaatgga tttcaggatc tccagtcgtg
     9241 tcaaaacatc ataatattcg actcacgatt gatacgttag aagatttttc tgtagcacag
     9301 agaatatata gggatttaca agaaaaaaga gtggaaatat cgatagaagt gattgtagac
     9361 tatgttcgaa gacatgcaga atacattcaa ctgatgaaac aacaaataaa aaaaaattct
     9421 aaataatgaa gaatacttat attattggtg aaatagggca gaatcataat ggttctgttg
     9481 acttggctaa gttgattatt gaattaatct cacgacctgt acatgaggat gtttttggta
     9541 tggatttcat gccaatgaat gctgttaaaa tgactaaaag agatttatca gaagaattgg
     9601 ctgtttctca aatgaatcaa atatatgaca atcctaattc ttttgggcgt acttatggtg
     9661 aacatcgtgc ttttcttgag cttgatgatc aagcgcattt tgagatttat aaatatgcta
     9721 agtcattagg attagatttt atcgagacgt tatgtgccaa aggatgtctg tctttgctta
     9781 aactgttcac accggatagg ctaaaagttg ctagtcgtga tttgactaac ttaccattgc
     9841 ttgaagcatt agcagaaact catattccta ttatattatc gacaggaatg gctggtcaaa
     9901 gagaacttga caatgcatta gatgtgataa cgagatatca tagtaatata gctattctac
     9961 attgtgtatc tcagtatcca actcatccaa ataatttgaa tctacgtaca ataacatatt
    10021 tgaagaagca ttacaataag tttgagatag gtttttctga tcatacaata ggtatttctg
    10081 ctgctacagc tgctgtagcg atgggagcgg aaattataga aaagcatgta acaattgatc
    10141 ggcatatgaa aggaacagac cagcttggct ctttaggtcc agatggggtt aatcgtatga
    10201 ttcgagatat tcgcatagca gagtgttggc ttggtactga agatctttat atagaaaaag
    10261 gggtggagaa gtctaagata aaacttgaac gttctattgc cactcgaaaa tatattccag
    10321 caggtagtat tattcaagag tcggacattc atttactgag tcctggtgat ggttataaat
    10381 ggatagataa aaaaaatgta attggtcatt ttgctaaaca agatatatca gcgaatgaaa
    10441 taatatatcc tgattttatt gaatagatat attcctactg caacttgtat tacggtatag
    10501 agtactgcct gctataagct aagtagtgat taataaataa gggtaaaata ctaaaaaaat
    10561 gaaagagata aagcttatac ttacagatat tgatggcgtt tggactgatg gcggaatgtt
    10621 ttatgatc
//
