LOCUS       c00199_gnlPro..        14567 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MGJAJOAL_199.
ACCESSION   c00199_gnlPro..
VERSION     c00199_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 13:47:19
            Original ID  :: gnl|Prokka|MGJAJOAL_199
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14567
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14567
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1009:4567](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1010..4567
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..14567
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14567
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             2..976
                     /locus_tag="ctg199_1"
                     /transl_table=11
                     /translation="NFYFSGHSLVDFANEFQKRGGKVLLIDQVFKHPEWSKELRMCYDR
                     FPSLKIVFTGSSVMRLKEENLELRDIAKSYNLRGFSFREFLNLQTGMKFRAYSLEEILS
                     THEQIAKGVLSKVRPLDYFQDYLHHGFYPFFLEKRNFSENLLKTMNMMVEVDILLIKQI
                     ELKYLSKIKKLLYLLAVDGPKAPNVSQLASDVQTSRATVMNYIKYLADARLINLVYPKG
                     EEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVLDTFFVNTLWKDHKVHKGDKNVSFMVDE
                     VMPFKICAEGTKIKNNPDVTYALQKAEIGRGNQIPLWMFGFLY"
     CDS             1010..4567
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg199_2"
                     /sec_met_domain="PFOR_II (E-value: 1.3e-18, bitscore: 58.2,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 1.9e-82, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 2.1e-31, bitscore: 100.3,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.8e-12, bitscore:
                     37.2, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 6.7e-12, bitscore: 37.2,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 1.2e-07, bitscore: 22.4,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 6.6e-05, bitscore: 14.4,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 3.2e-25, bitscore: 78.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMKPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDHLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKSIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQIISVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDTPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIAMEIGLGNRTNTILQSAFFRITGVIPV
                     DQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLTVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTSKYEKRGVAAFVPEWNAENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKAFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAEADNWTYCAENVKSKQHLVDIKANVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTMNEKGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARLVKVMNEAIASDCCPAEYKEVFAEWINNMLDAEKTKE
                     LAEKIIPMVEAAKDKCNHCKQIADLQQYLVKRSQWIIGGDGASYDIGYGGLDHVIASGK
                     DVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQIA
                     MGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLWR
                     YNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPAEAEELFKAAEENAKW
                     RYNSYKRLARENWGADTAE"
     CDS             4692..4880
                     /locus_tag="ctg199_3"
                     /transl_table=11
                     /translation="MIGFVIWIIGLILTFRAAIEIWNINAAVEKRLIAIVLIVLTSWLG
                     LLFYYFYGKERMAGWLK"
     CDS             complement(4891..5751)
                     /locus_tag="ctg199_4"
                     /transl_table=11
                     /translation="MNKIKMIAAMFIAGILLTFVSCGDNGKSKKISIAYANWSEGIAMT
                     NLAKAIFEDQGYDVKLLNADLAPIFTSISRKKADVFMDVWMPVTMEDYMKQYGDKLEVI
                     GDIYDGARIGLVVPDYVTINSIEELNAEKERFSGQIVGIDAGAGIMKATDQAIKDYGLD
                     YKLMTSSGPAMTASLKKAIDKKDWIVVTGWTPHWMFDRFKLKVLQDPKLIYGNTESIHT
                     IAWKGFSEKDPFAAELLGNIRLTDAEISSLMTALEEAQTTERQAARQWMEEHQELVNSW
                     IPEKD"
     CDS             complement(5779..6609)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 91.7; E-value: 1.6e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg199_5"
                     /sec_met_domain="BPD_transp_1 (E-value: 7.5e-29, bitscore:
                     91.7, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIEAAINWLTEHFASFFDALSMGIGGFIDGFQHVLFGIP
                     FYITIAVLAALAWFKSGKGTAVFTLLGLLLIYGMGFWEETMQTLALVLSSTCLALLLGV
                     PLGIWTANSDRCNKIMRPVLDFMQTMPAFVYLIPAVLFFGLGTVPGAFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATPWQLLYKVQLPLALPTILTGINQTIMMSLSMVVIA
                     AMISAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIVLDRITQGMADNRKSKKK"
     CDS             complement(6606..7832)
                     /locus_tag="ctg199_6"
                     /transl_table=11
                     /translation="MSKIEIKDLYLVFGNEKQKALKMLKEGKTKSEILKATGCTVAVKD
                     ANLSINEGEIFVIMGLSGSGKSTLLRCINRLIRPTSGEVIINGTDIAKVSDKELLQIRR
                     KELAMVFQNFGLLPHRSVLHNIAFGLELQGVKKGEREQKAMESMQLVGLKGYENQMVSE
                     LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLTLQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEIVQIGTSEEILTEPANAYVERFVENVDRSKIITASSVMVD
                     KPIVARLKKEGPEVLIRKMRERNLTVLPVVDSNNLLVGEVRLNDLLKLRKEQIRSIESV
                     VRHEVHSVLGDTVLEDILPLMTKTNSPIWVVNENREFEGVVPLSSLIIEVTGKDKEEIN
                     EIIQNAIEL"
     CDS             8305..9591
                     /locus_tag="ctg199_7"
                     /transl_table=11
                     /translation="MFNRAITIFLGKDNCHYTTKEKQTGTATLDDKSQVQFLSKKNPKM
                     PFFYSRRNLYMIGFLLAFIVTLLEFIRGRHQNFMVFSDATQFFWQGISPYTTEFVETHG
                     RYFLYSPVFTVLFAPFAYLPAWLGPFAWNLFNYSLFFMAIFTLPQQFTQQQKCRMFLFL
                     LLILGQSLLSFQYNITVAYLFLFAYTLLEKDRGFLAVLLIMISGCTKVYGIFELALLLC
                     YPHVWRNFGYAVTMGIVLLALPLIKIAPADLLPYYEEWCHSLAVHQSAGAYDSFFYARP
                     IAAWTLPHFRALQIGMLGLLTLLFLGNFRKWSSFAFRAQALGILMGWVVLLSDSAEKHT
                     YIIALAGFMLWYWSRPTRTATDKILFWCCFVLLCIVPIDIFVPVPIRDFITRTLWLHVW
                     VFFIVWIRMIWLTFLASFIHPRATNVLSD"
     CDS             complement(9554..9886)
                     /locus_tag="ctg199_8"
                     /transl_table=11
                     /translation="MKDYKVDKESFSESFRKEVYEVVSQIPVGKVSTYGGIALLLGAPQ
                     CSRMVGRALKEVPDELSIPCHRVVNSTGRLVPGWVEQKQLLLAEEVSFKANGCVNLKEH
                     LWHVDE"
     CDS             complement(9914..12703)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 64.2; E-value: 4.3e-20)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg199_9"
                     /sec_met_domain="Peripla_BP_1 (E-value: 2e-20, bitscore:
                     64.2, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LDYRKNYEMMRWMKTMRYLKWMLVLFGLIGMTACRQDTPHFRIGV
                     AQCSDDSWRHKMNDEILREAMFYNGVSVEIRSAGDDNSKQAEDVHYFMDEGVDLLIISA
                     NEAAPMTPIVEEAYQKGIPVILVDRKILSDKYTAYIGADNYEIGRSVGNYIASSLKGKG
                     NIVELTGLSGSTPAMERHQGFMAAISKFPDIKLIDKADAAWERGPAEIEMDSMLRRHPK
                     IDAVYAHNDRIAPGAYQAAKMAGREKEMIFVGIDALPGKGNGLELVLDSVLDATFIYPT
                     NGDKVLQLAMDILEKKPYPKETVMNTAVVDRTNAHVMQLQTTHISELDKKIETLNGRIG
                     GYLSQVATQQVVLYGSLIILLLVAGLLLVVYKSLRSKNRLNKELFKQKQQLEEQRDKLE
                     EQRDQLIQLSHQLEEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADKTLSEDQHRML
                     MLIQRNVNILLRLVNQILDFRKYENGKMEYTPVTVDVLSSFEGWNESFQAAARKKHIHF
                     SFDSMPDTDYHTLADVEKLERIYFNLLSNAFKFTPENGKIAVRLSSLSKEDKRWIRFTV
                     ANTGSMISAEHIRNVFDRFYKIDMHHTGSGIGLALVKAFVEMHGGMISVESDEKQGTVF
                     TVELPVQSCEAVAAKPDTTLVSADSRTTDVLLAEEEELEKGYDSSKPSVLIIDDNEDIR
                     SYVHTLLHTDYTVIEAADGSEGIRKAMKYVPDLIISDVMMPGIDGIECCRRLKSELQTC
                     HIPVILLTACSLDEQRIQGYDGGADSYISKPFSSQLLLARVRNLIDSHRRLKQFFGDGQ
                     TLAKEDVCDMDKDFVERFKSLIEEKMGDSGLNVEDLGKDMGLSRVQLYRKIKSLTNYSP
                     NELLRIARLKKAASLLASSDMTVAEIGYEVGFSSPSYFAKCYKEQFGESPTDFLKRKG"
     CDS             complement(13000..14226)
                     /locus_tag="ctg199_10"
                     /transl_table=11
                     /translation="MFFFLIVPLFLALFYKPIAYLCGRFLNNKSKRENYFMKHISNFLR
                     SKSWNVFLFLYLALPLFAQKEYKIDQVSVVNVGDGRLLFQELKTEKALNGEHRIIDGYH
                     SAYVLASFKDGFYDGGYKEYVDNILITEGSYKEGRKDGLFKINSKFDGKLKEEKSYKEG
                     KLDGTSKSYFTTGKVESERNFRMGKEHGKQLSYESDGTLRKEHNYKDGKQVGKQYTFLK
                     GTYDLYETVYFNEEGLQDGEYSSVFTFGSPRILGSYKNGKKNGRWTTFAESGDTLMIET
                     YLDGKEDGLHVSFANGSGVRQKEYYMKNDRKDGLYREYNLENGELRYEATYQAGRLHGK
                     ERRLIVSNRFDYWETSTYVNGRQNGPFEACYVKNDQLRECGEYKNGRRVGRWKRYTIDG
                     KLEKEWDEN"
ORIGIN
        1 caacttttat ttctccggtc acagccttgt tgacttcgcc aacgagtttc agaaacgtgg
       61 cggaaaagta ctgctgatcg accaggtgtt caaacatccc gaatggagca aagagctacg
      121 aatgtgctat gaccgtttcc ccagcctgaa gattgtcttc accggttctt ccgtcatgcg
      181 actcaaagag gaaaacctcg aattgcgtga cattgcgaaa agttataacc tgcgcggatt
      241 ctctttccgt gaatttctga acctgcagac aggaatgaaa ttccgggcat acagcctcga
      301 agaaatcctc agtacacatg aacagatagc caaaggagta ctttccaaag tacgaccgct
      361 ggattatttt caggattacc tgcatcatgg tttctaccct ttcttccttg aaaaacgtaa
      421 tttctcggag aatctgctga aaacaatgaa catgatggta gaagtggata tcttgctgat
      481 caaacaaatt gagctgaaat atctttcaaa gataaaaaaa ttactatatt tgttggctgt
      541 ggacggaccg aaagctccga acgtgagcca actggcaagt gacgtacaga catcccgcgc
      601 tacggtaatg aactatatca agtatctggc agacgcgcgt ctgattaatc tggtttaccc
      661 gaaaggagaa gaattcccaa agaaaccgtc aaagattatg atgcacaact ctaacctgat
      721 gtactccatt tatccggtga aagtggaaga acaggatgta ctcgacacgt tcttcgttaa
      781 cactttatgg aaagaccata aggtacataa aggagataaa aacgtctctt tcatggtaga
      841 cgaagtgatg ccgttcaaaa tttgtgcgga aggtacaaaa ataaagaata acccggacgt
      901 gacgtatgcg ttgcaaaagg ctgagatagg ccgcggcaac caaatacctc tctggatgtt
      961 cggattctta tactaaaaag atttatttac ttaaatattt aatttagtta tgactaaaca
     1021 gaagaaattc atcacatgtg atggtaacca agctgcagca catatctcgt atatgttctc
     1081 tgaagtagca gctatctacc ccatcactcc ttcttcgact atggctgagt acgtagacga
     1141 atgggctgcc gcaggacgta agaacatctt cggcgaaaca gtattggtac aggaaatgca
     1201 atctgaaggt ggtgctgccg gtgcagttca cggttctctt caggctggtg cattgactac
     1261 tacttacact gcttctcagg gtcttctttt gatgatccct aacatgtaca agattgccgg
     1321 tgaattcttg ccttgtgtat tccacgtttc tgctcgtaca ctggcttctc acgcattgtg
     1381 tatcttcggt gaccatcagg acgtaatgtc agctcgtcaa accggcttcg ctatgttggc
     1441 agaaggttct gtacaggaag ttatggattt ggcaggtgtt gctcatctgg ctactatcaa
     1501 atcacgcgtt ccgttcatga acttcttcga tggtttccgt acttctcacg aaatccagaa
     1561 gatcgaaatg ttggaaaacg acgacctcgc tccgctgatc gaccaggaag ctttggctga
     1621 attccgtgcc cgtgcactga atccgatgaa gccggttgcc cgtggtatgg ctgaaaaccc
     1681 cgaccacttc ttccaacatc gtgaatcatg caataactac tatgaagcag ttcctgctat
     1741 cgtagaagaa tacatgaacg aaatttccaa gatcacaggc cgcaaatacg gtttgttcga
     1801 ttactacggt gcagaagatg cagaacgcgt aattatcgca atgggttctg taactgaagc
     1861 tgcccgcgaa gctatcgacc acttggtagc aaacggtgaa aaagtaggta tggttgccgt
     1921 acacttgtat cgtccgttct ctgccaaaca cttcctggct gctgtaccca agactgcaaa
     1981 gagcatcgca gtgcttgacc gtacaaaaga accgggtgct aacggcgaac ctctttacct
     2041 tgacgttaaa gactgcttct atggcgcaga aaatgctcct gttatcgttg gcggtcgcta
     2101 cggtctgggt tctaaagata caactccggc acagatcatc tctgtattcg agaacttggc
     2161 tatgccaatg ccgaagaacc acttcactat cggtatcgta gacgacgtta cgttcacttc
     2221 tcttcctcag aaagaagaaa tagctctggg cggtgaaggt atgttcgaag ctaaattcta
     2281 cggtctgggt gctgacggta ctgtaggtgc caacaagaac tctgttaaga ttatcggtga
     2341 caacaccgac aaacactgtc aggcttactt ctcttacgac tccaagaagt cgggtggttt
     2401 cacttgttct cacttgcgtt tcggtgatac tccgatccgt tctacttact tggtaaatac
     2461 tccgaacttc gttgcttgtc acgttcaggc ttacctgcac atgtacgacg taacacgtgg
     2521 tttgcgtaag aacggttctt tcttgctgaa taccatctgg gaaggcgaag aactggctaa
     2581 gaacctgcct aacaaggtga agaaatactt tgcacagaac aacatctctg tatactatat
     2641 caacgcaact cagattgcaa tggaaattgg tttgggcaac cgtaccaata caatccttca
     2701 gtctgcattc ttccgtatca caggcgtaat ccctgtagat caagctgttg aacagatgaa
     2761 gaaattcatc gttaagtctt acggcaagaa gggtgaagac gttgttaaca agaactacgc
     2821 tgctgtagac cgcggtggtg aatacaagac tctgactgtc gatcctgctt gggctaacct
     2881 gccggatgat gcaaaagcag aaaacaatga tcctgctttc atcaacgaag tagttcgtcc
     2941 gatcaatgca caggacggtg acttgctgcc ggtatctgca ttcaagggta tcgaagacgg
     3001 tacttggtat caaggtactt ccaaatacga aaaacgtggt gtagctgcat tcgttcccga
     3061 atggaatgct gaaaactgta ttcagtgtaa caagtgtgct tacgtttgtc ctcacgcttc
     3121 tatccgtccg ttcgtactcg atgctgaaga gcagaagggt gctaagttcg agcaactgaa
     3181 agctgtaggt aaagcattcg atggtatgac attccgtatt caggtagacg ttctcgattg
     3241 tctgggttgc ggtaactgtg ccgacatctg tccgggtaat ccgaagaagg gtggcaaggc
     3301 attgaccatg aaacaccttg aaagccagtt ggccgaagct gataactgga cttactgcgc
     3361 tgaaaacgtg aagagcaaac aacacctggt agacatcaag gctaacgtga agaactctca
     3421 gttcgcaact ccgttgtttg agttctcagg cgcttgctcc ggttgtggtg aaactccgta
     3481 cgtgaaactg atttctcagt tgttcggtga ccgtgaaatg gttgctaacg ctacaggatg
     3541 ttcttctatc tactccggtt cagttccttc tactccgtac actatgaacg aaaagggtca
     3601 cggtcctgca tgggctaact ccttgttcga agacttctgt gaatttggtc tgggtatgga
     3661 actggctaac gaaaagatgc gtgcccgtct ggtgaaagta atgaacgaag ctatcgcttc
     3721 tgattgctgc ccggctgaat acaaagaagt atttgctgaa tggatcaaca atatgctgga
     3781 tgcagaaaag actaaggaac tggccgaaaa gatcattccg atggtagaag ctgctaaaga
     3841 taaatgcaac cactgcaagc aaatcgctga tctgcaacaa tatcttgtta aacgcagcca
     3901 atggatcatc ggtggtgacg gtgcttctta tgatatcggt tacggtggtc ttgaccatgt
     3961 aatcgcttcc ggtaaggacg ttaacatcct tgtattggat actgaggttt actctaacac
     4021 aggtggtcag tcttctaaag ctactccggt aggcgctatc gctaagtttg ctgctgcagg
     4081 taagcgtgta cgtaagaaag acctcggtct gatggctact acttacggtt atgtatatgt
     4141 tgctcagatt gctatgggtg ctgaccaggc tcagactctg aaagctatcc gtgaagctga
     4201 agcatatccg ggaccatcac tgatcatcgc ttacgctcca tgtatcaacc acggtctgaa
     4261 agccggtatg ggtaagagcc aggaagaaga agaaaaggct gttaagtgcg gttactggca
     4321 cttgtggcgt tacaaccctg ctttggaaga agaaggcaag aatccgttcc aactggatag
     4381 caaagaacct aactgggaag acttccaagg tttcttgaag ggtgaagttc gttacgcttc
     4441 tgtaatgaaa caatatcctg ctgaagctga agaactgttt aaagctgctg aagaaaacgc
     4501 taaatggcgt tacaacagct acaaacgtct tgccagagaa aactggggag ctgatacagc
     4561 tgaataataa gtagaaatac tttgtacata ataaaaggca ggaatcctgg aaacagattc
     4621 ctgccttttt ggtttatatc ttagaagtaa cgattacttc tcacgaagat attcattaaa
     4681 actctaaaga tatgatcgga tttgttattt ggattatcgg tttgatactg actttcagag
     4741 ctgccataga gatttggaat ataaatgcgg ctgtagagaa aagacttata gcgattgtat
     4801 taatcgttct taccagctgg ctgggactac ttttctacta cttctatggt aaagaaagaa
     4861 tggcgggatg gttgaagtag tgtttgcata tcaatctttc tcaggaatcc aactgtttac
     4921 cagttcctga tgttcttcca tccattgacg ggcagcctgt ctttccgttg tctgcgcctc
     4981 ttccagagca gtcattaagg agctgatttc cgcatctgtc agacgaatgt tgcccaaaag
     5041 ttcggcagca aaagggtcct tctcgctaaa acctttccat gctatggtat gaatggattc
     5101 cgtatttcca tatatcagct tcgggtcctg aagaactttc agcttgaaac ggtcgaacat
     5161 ccagtgaggc gtccatcccg tcacgacaat ccagtctttc ttatcaatcg ctttctttag
     5221 ggaagcagtc atggcaggtc cgctcgaagt catcagttta taatccaatc catagtcttt
     5281 gatggcctga tcggtagctt tcataatacc ggctccggca tcaataccga caatctgacc
     5341 ggagaaacgt tccttttccg cgttcagttc ttcgattgag ttgatcgtaa cgtaatccgg
     5401 aaccaccagc ccgatacggg caccatcata aatatccccg ataacttcga gtttatcccc
     5461 gtattgtttc atataatctt ccatagtgac aggcatccag acatccataa atacgtctgc
     5521 tttcttacgg gagatagagg taaatatagg tgcaaggtcg gcattcagca actttacatc
     5581 gtacccctga tcttcaaaaa tcgctttggc aaggtttgtc attgcaatac cttccgacca
     5641 gttggcataa gcgatactta tcttcttact ctttccgttg tctccgcagg aaacgaaggt
     5701 taagagtatg ccggcaataa acattgccgc aatcattttt atcttattca ttgattattc
     5761 ctttctttgg tgtgattctt atttcttttt actttttctg ttatctgcca taccctgagt
     5821 gatgcggtcc agcacgatcg ccaatatcac gactgcgata ccgccttcaa atccgagtcc
     5881 gattttcatt tgggtgatac ctttcagcac gatttctccc aatcctccgg cagaaatcat
     5941 ggcagcaatc actaccatcg aaagtgacat catgatcgtc tgattgattc ccgtcagaat
     6001 tgtaggcaat gccaaaggca attgcacctt ataaagaagc tgccagggag tagctccaaa
     6061 agaacgggag gcttctacta cgtttttagg aacctgacga atgcccagac cggtcagacg
     6121 aaccacagga ggcattgcaa agatgatggt ggcaaaagct cccggcacag ttcccaatcc
     6181 gaagaatagg acagcaggaa tcagatagac aaaggcaggc attgtctgca taaagtcgag
     6241 gacagggcgc attatcttgt tacaacgatc actgttggca gtccagattc ccaacggaac
     6301 gcctaaaagc aatgccagac aagtggaaga aagtaccaat gccaatgtct gcatcgtttc
     6361 ttcccaaaag cccatgccgt aaataagcaa taaacccaag agggtaaata cggctgtccc
     6421 cttacccgac ttaaaccagg cgagcgcagc cagcactgca attgtgatat aaaaaggtat
     6481 tccaaacagt acatgctgaa aaccgtctat gaatcctccg atccccatgc tgagagcatc
     6541 aaaaaaggaa gcaaaatgtt ctgtgagcca attaatggca gcctctatat attgtccgat
     6601 atttatcata attctattgc gttttgaatg atttcattaa tttcttcttt atcttttccc
     6661 gttacttcga tgatcaatga ggaaagtggc actacgcctt caaactcccg attctcattt
     6721 acgacccaga ttggcgagtt cgtttttgtc atcaacggaa gaatatcttc cagcaccgta
     6781 tcacccagca ctgaatgaac ttcatgcctt actacggact cgatggagcg gatttgctct
     6841 tttcgtagtt tcagcaagtc attcaaccgc acctctccta ctaacagatt attggaatcg
     6901 actaccggaa gaacggtcag attccgttcg cgcatcttac ggatcagcac ctccgggcct
     6961 tctttcttca aacgtgccac tatgggttta tctaccataa cagaggaagc tgttataatc
     7021 ttgcttcgat ctacattctc cacaaatcgt tctacataag cgttggcagg ttcggtcagg
     7081 atttcttccg atgtaccgat ttgtacaatt tctccatcct tcatgatagc aatccggtca
     7141 cccaatttaa tcgcttcact caggtcgtga gtaataaaga caatcgtttt tttcatcttc
     7201 gactgcaaag tcagcagttc atcctgcatc tgcacacgga tcaaaggatc gagtgccgag
     7261 aaggcctcat ccatcaacag gacttcggga ttattggcca aagcccgcgc cagcccgaca
     7321 cgctgctgca tcccacccga cagttcactt accatctgat tctcgtagcc tttcagcccc
     7381 accagttgca tactttccat cgctttctgc tcccgttctc ccttttttac tccctgtagt
     7441 tcgagcccga aagctatatt atgcaagaca gaacggtgag gaagcagacc gaagttctga
     7501 aagaccatag ccagttcttt ccggcgaatc tgcaacagtt ccttatccga cactttggct
     7561 atgtctgttc cattgataat cacttctccg gaagtagggc gtatcaaacg gttgatgcag
     7621 cggagtaaag tggactttcc actaccggac agccccataa tgacgaatat ttcgccttca
     7681 ttaatggaaa gattcgcatc tttcaccgca actgtacatc cggtcgcttt caatatttca
     7741 ctttttgttt taccttcttt caacatcttc aaagccttct gcttctcatt gccaaaaacc
     7801 agatagagat ctttaatttc tattttactc atacaataaa atggtttagg ttattaaaat
     7861 aatatacaca gcaagacaag aacaaacgat aacaggaatc tttctttata tcgtataaag
     7921 ttctgattta aataagggac aaataacaat gaatcccgaa ataattaata aaatgattat
     7981 tgacagactg agtaattaaa aaaggaatag aatttgataa gataatcctt tcaacgaata
     8041 gcaaaaaata gcatttttat gtataaaaac agcctgttcc agtatcttgc tggcacaaag
     8101 atacaaaaaa cggattaaac atacaaatta tattcaaaat tcggggcata cagagggctt
     8161 tatttgtaat gatatggaaa gtttccgggt aatattcccc tatcactcag caaaatagaa
     8221 caaaccggca gataaatata aaataagttt gaatatttca cttaaacacc gtatatttgg
     8281 cgtcaataac taaactagat ttatatgttc aacagggcta ttacaatttt cctggggaag
     8341 gataattgtc attacacaac aaaagaaaaa caaacaggta ctgccacact agacgacaaa
     8401 agccaagtac agttccttag taaaaagaac cccaaaatgc cgtttttcta tagccggcgg
     8461 aatctctaca tgataggttt cctgctcgct tttatagtga ctctgctcga atttatacga
     8521 ggacggcatc aaaactttat ggtcttctcg gacgctactc aattcttctg gcaaggcatc
     8581 agcccataca caactgaatt tgtagaaact cacggacgct acttccttta ttctccagtt
     8641 ttcacggtat tgttcgctcc gtttgcgtat ctgcctgcat ggctgggacc tttcgcgtgg
     8701 aatctattca attattcgct gttctttatg gcgatcttca cgctgcccca acaattcacg
     8761 cagcagcaga aatgccgtat gttccttttt ctgttactga ttttaggaca aagtttactt
     8821 tcatttcagt ataacataac ggtagcctat ttattcttat tcgcctatac gttattggaa
     8881 aaagaccgtg gatttctggc tgttctgtta atcatgattt cgggatgtac caaagtatat
     8941 ggaattttcg aactggcatt gttgctgtgc tatcctcacg tatggcgtaa ctttggctat
     9001 gccgttacaa tgggcattgt attgcttgca ttaccgttaa tcaaaatagc tcctgcagat
     9061 ttgctcccct attatgaaga atggtgccat agtcttgctg ttcatcagtc cgccggagct
     9121 tatgattcat ttttctatgc ccgccccatt gcagcatgga cattgccaca cttccgtgca
     9181 cttcagatag gaatgctcgg cttgctgact ctgctctttt tggggaattt ccgcaaatgg
     9241 tcgtcttttg ccttccgtgc ccaggctttg ggcattctca tgggctgggt agtattactg
     9301 agtgactccg ccgagaagca tacctatatt atcgcattgg caggtttcat gctctggtat
     9361 tggagcagac caacacgtac cgcaacagac aagattctat tttggtgctg ttttgtgctg
     9421 ttatgtatcg ttcctatcga catattcgtc cctgtaccca tcagagattt cattaccagg
     9481 accttatggc ttcatgtatg ggttttcttt attgtatgga tacggatgat atggcttacc
     9541 ttccttgcat ccttcattca tccacgtgcc acaaatgttc tttcagatta acgcatccgt
     9601 tagctttgaa agaaacttct tctgccagca agagttgttt ttgttccacc caaccgggca
     9661 ccagccttcc ggtggaattt acaactctat ggcagggaat ggataattca tccggcactt
     9721 ctttcaatgc acgtcccacc atccgcgagc attggggtgc ccccaacagc aaagcaatac
     9781 ctccataagt agatactttt cccacaggta tctgggatac gacttcgtac acttccttcc
     9841 gaaaggattc ggaaaagctc tctttatcta ctttataatc tttcatatat ccctctttac
     9901 gatatcaatg aaatcatcct ttccttttca ggaaatctgt cgggctctct ccaaactgct
     9961 ctttatagca cttggcgaaa taagaaggtg aactgaaacc gacttcataa ccaatctccg
    10021 ctacggtcat gtccgaagaa gcaagcaaag aagctgcctt cttcaaacgg gcgatacgga
    10081 gcaattcatt cggagagtag ttagtcaatg atttaatctt gcgataaagc tgcacacggc
    10141 ttagtcccat gtctttgccc aagtcctcca cattcaaacc ggagtctccc attttctctt
    10201 caatcaatga cttgaatctt tctacaaaat ccttgtccat atcgcagaca tcttcttttg
    10261 ccaatgtctg cccgtcacca aagaactgtt tcagacgacg gtgagaatca atcagattgc
    10321 ggacacgtgc cagcaacagc tgtgaactga acggctttga aatataagaa tccgcaccac
    10381 cgtcatatcc ctgaatacgc tgttcgtcca gtgaacacgc tgtcagcaga ataaccggaa
    10441 tatgacaggt ctgtaactca cttttcagcc ggcggcaaca ttcaatgcca tcaatgcccg
    10501 gcatcatcac atcagaaatg atcaggtccg gaacatactt catagcctta cggattcctt
    10561 cggagccgtc tgccgcttca atcaccgtat agtctgtatg caacaacgta tggacatacg
    10621 aacggatatc ctcattatca tcaataatca gtacggacgg tttggaagag tcatatcctt
    10681 tttccagttc ttcctcttcc gccaatagaa catctgttgt acgggaatcc gcagaaacaa
    10741 gggtggtatc cggtttggca gcaacagcct cacaagactg tacgggcagt tcaacggtaa
    10801 agaccgtgcc ctgtttctca tcactctcta cggagatcat accaccgtgc atttctacga
    10861 aggcttttac caatgccagt ccgattcccg aaccggtatg gtgcatatcg atcttataga
    10921 aacggtcgaa tacattgcga atatgttcgg cagaaatcat agaaccggta tttgccaccg
    10981 tgaaacgtat ccatcgcttg tcctctttac taagggaaga cagacggaca gctattttcc
    11041 cgttttccgg tgtaaactta aaggcattgg acagaagatt gaaataaata cgttccagct
    11101 tctccacgtc tgccagtgta tgataatccg tatccggcat actatcaaaa gaaaaatgga
    11161 tatgcttctt acgggctgcc gcctgaaaag actcattcca tccttcgaaa gaagaaagga
    11221 catccaccgt aaccggagta tattccatct tgccgttttc atatttacgg aaatccagaa
    11281 tctgattgac cagacgcaga agaatgttca cattccgctg aatcagcatg agcatccggt
    11341 gctgatcttc gctcagtgtc ttgtccgcca acaaatgttc taccgggtcg gcaaccaatg
    11401 tcaacggagt acggaagtcg tgagaaatat tggtgaaaaa gaccagcttg gcatgggtag
    11461 cttcttccag ttgatgagag agctgtatca attggtcacg ctgttcttcc agtttgtcac
    11521 gctgctcttc caattgctgc ttctgcttaa aaagctcttt attcaagcga ttcttagagc
    11581 ggagtgattt ataaacgacc aataataaac cggctaccaa taaaaggata atcagactgc
    11641 cgtataaaac gacctgttgt gtagctacct gagagagata gccaccgata cgtccgttga
    11701 gcgtttcaat ctttttgtcg agttcggaaa tgtgtgtggt ctgcaactgc atgacgtgtg
    11761 cgttggtacg gtccacaaca gcggtattca tcactgtttc tttgggatag ggtttcttct
    11821 ccagaatgtc catagccagt tgcagtacct tatcgccatt ggtcggatag ataaaggtgg
    11881 catccagcac actgtccaga accagttcca gtccgtttcc cttacccggc aaggcatcta
    11941 tgccgacaaa aatcatttcc ttctcccgcc ctgccatctt tgctgcctga taggcacccg
    12001 gagcgatacg gtcattatgg gcatacacag catcaatctt aggatgcctc cgaagcatac
    12061 tatccatttc tatctctgcc ggaccacgtt cccacgcagc atccgcttta tcaatcagct
    12121 ttatatccgg gaatttactg atggcagcca taaatccctg atgccgttcc attgcaggag
    12181 tcgaaccgct caatcctgtc agttctacta tatttccctt ccctttcaga ctggaggcaa
    12241 tatagtttcc taccgaacga ccgatttcat aattatcggc tccgatatag gcagtatatt
    12301 tatccgaaag aatcttccgg tctacaagaa taacggggat gcctttctga taagcttctt
    12361 ctacaatcgg agtcatagga gcagcttcgt tagcggaaat aatcagcaga tcgactcctt
    12421 cgtccataaa ataatggaca tcttccgcct gcttactgtt atcatcccct gccgaacgga
    12481 tttccaccga aacgccatta taaaacattg cttcccgaag aatctcatca ttcatcttat
    12541 gtcgccatga atcatcgctg cattgagcca ccccaatacg aaaatggggt gtatcctgcc
    12601 ggcaagccgt catcccgatt aaaccaaaca gcaccagcat ccacttcaga tatctcatcg
    12661 tcttcatcca tctcatcatt tcatagttct ttctgtaatc caattaagaa caaaaataag
    12721 aaataatact gtaaagttct ctaacttcag ctatttatta ttctaaaaag aaggaaagca
    12781 gtcctctttc agaccatcgg aaagtattaa caaaagtata aagcgtaaaa caaacactta
    12841 atcaatgtta taaaacatag cgttttactt ggataatttg cagatttcac agaagtccgt
    12901 atctttgcac tgtgtttttc atagtattag atttaaggtt aacaaaggtt ggagcaaggc
    12961 gttgctcctt tttttatgcc ctgacctttc atctaccggt tagttttcat cccattcctt
    13021 ttccagttta ccatcaatag tgtagcgttt ccatcgtcct acacggcgac cattcttata
    13081 ttccccacat tcacgaagct ggtcattctt tacataacaa gcttcgaacg gtccgttctg
    13141 ccttccgttc acataggtag aagtttccca ataatcaaag cggttgctca ctatcagccg
    13201 tcgttccttg ccatgcaatc tgccggcctg ataggtagct tcatatctca attcaccatt
    13261 ttccagatta tattcacggt ataaaccgtc tttacgatcg ttcttcatat aatattcttt
    13321 ctgccttacc ccacttccgt tggcaaatga gacatggagt ccatcttctt ttccatccag
    13381 ataggtttca atcatcagcg tatctccgct ttcagcaaaa gtagtccacc gaccattctt
    13441 ctttccattc ttataactac ccagtatacg tggcgagcca aacgtaaaca cggacgaata
    13501 ttcaccgtcc tgcaaacctt cttcattaaa ataaacggtc tcatacaaat catatgtacc
    13561 tttcagaaaa gtatactgtt tgcctacctg cttcccgtcc ttgtaattat gctctttccg
    13621 caaagtaccg tcagattcgt acgacagttg cttcccgtgc tctttcccca tccggaagtt
    13681 tctttcactt tccacttttc cggtagtaaa gtaacttttg ctcgtaccat ccagcttacc
    13741 ttccttatag gacttttctt ctttcagctt accgtcaaac ttggagttaa tcttgaagag
    13801 gccatccttc cgcccttctt tataacttcc ttccgttatt aatatattgt ccacatattc
    13861 tttgtatccg ccatcataaa aaccatcttt aaaagatgcc agcacatagg cggaatgata
    13921 accatctatg atgcgatgtt cgccattcaa tgctttttcc gttttcagtt cctgaaacaa
    13981 cagtctgcca tcgcctacat taacaacaga tacctgatcg atcttatatt ccttttgcgc
    14041 aaacaaagga agagcaagat ataaaaacaa aaatacgttc cagctttttg atctgaggaa
    14101 gttcgaaatg tgtttcataa agtagttttc tctttttgat ttattattta aaaacctgcc
    14161 gcaaagatag gcaatcggct tataaaacaa ggcaagaaag agggggacaa ttagaaaaaa
    14221 gaacatctgt tattatcatt ctaataatta acagattaag tagtaaatca aaacacaggg
    14281 aagggggaca ttnnnnnnnn nngaaataag aaacagaaaa gaagatgtgt caaaagcaac
    14341 taaattcccc tccttcagga agagtttagt tgcttttgac acaccttctt tttgaattta
    14401 aagagattct acaacaatct gtctttcaga acaaccggaa gttcgggcat tgcaccgctc
    14461 tgcgtacaaa cataagcgga aacttcgaca gccagcttat gagcttcggg aacagacttg
    14521 ccattcagaa tggaagcaca gaaagcggca gtaaaggaat cccccgc
//
