LOCUS       gnlProkkaNPANFECM_53   10668 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NPANFECM_53.
ACCESSION   gnlProkkaNPANFECM_53
VERSION     gnlProkkaNPANFECM_53
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 10:30:27
            Original ID  :: gnl|Prokka|NPANFECM_53
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10668
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..132
                     /locus_tag="ctg53_1"
                     /transl_table=11
                     /translation="MGCEIIVPSKAKKKGNIANILGYATSFSSLGMMIASIANLIKK"
     protocluster    1..10668
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[1354:5668]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1355..5668
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..10668
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10668
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             143..1291
                     /locus_tag="ctg53_2"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             1355..2074
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_3"
                     /sec_met_domain="NTP_transf_3 (E-value: 1.7e-14, bitscore:
                     44.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMRTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CDIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             2095..3396
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_4"
                     /sec_met_domain="CTP_transf_like (E-value: 3.1e-13,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 3.2e-121, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 3.6e-63, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             3413..4537
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_5"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.7e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.4e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             4547..5668
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg53_6_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_6"
                     /sec_met_domain="Aminotran_5 (E-value: 2.4e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        4637..5644
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg53_6_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg53_6_Aminotran_5.1"
                     /locus_tag="ctg53_6"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             5665..5808
                     /locus_tag="ctg53_7"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             6011..7495
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg53_8"
                     /sec_met_domain="Polysacc_synt (E-value: 2.1e-31, bitscore:
                     99.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKQKTVSGIMWSAIERFSLQGVQFIIQIILARLLLPSDYGMI
                     GMLAIFLQVAQVFIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIA
                     DFYNMPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWM
                     AYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLIN
                     TVYRNLYTIVIGKKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCL
                     TNAYRNYIRLSSYIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQ
                     INLNLLWVKGRSDLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYY
                     TNSLIDLTLKLQVKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCITGMSFYILLS
                     FLFKLDSFFCILTLIIKTKNIDENIKKDFSSNSKDN"
     CDS             7449..8708
                     /locus_tag="ctg53_9"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLVNKPVIF
                     NFYDIEEYRRVRGFSFEPIEFFCAGDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLM
                     NQFQDDNSTKRICDIFLNEI"
     CDS             8717..9466
                     /locus_tag="ctg53_10"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKNSK"
     CDS             9466..10506
                     /locus_tag="ctg53_11"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEII
                     YPDFIE"
ORIGIN
        1 ccgggatgtg agattattgt gcctagtaag gctaagaaga aagggaacat agctaatatt
       61 ttaggttatg ctacttcctt cagttctttg ggaatgatga ttgcttctat tgctaatttg
      121 ataaagaaat aaatgaccta ttatgattga aaagcaatct tatcaagaac cgttttctga
      181 agtggataaa aggaaagatg atgaaatgga aatagacttg atggctattt tttataagat
      241 tattactgtt cgtggagtac tatgcaaagc tgctggagtg ggagtaataa ttgctatagt
      301 ggtggcattg agcattccca agcaatatac agtaaaggtt accctttctc ctgaaatggg
      361 taatgcgaag ggaagtaatg gtttagccgg acttgctgcc tcgtttttgg gagatggggc
      421 tctaataggg gaaagcacag atgccttgaa cgcttctctt tcagcagata ttgtttcttc
      481 aactcctttt ttattggaac ttttagaaat ggaagtctcc gtttctaaaa aggatgataa
      541 aatgactttg gggtcttatc tcgatgaaga gtcatctcct tggtgggatt atcttatagg
      601 ttttccgggc atagtaatag gaggagttaa atcattattc ggagaagata cggttcctgc
      661 cagtggaggg cggcaaggaa ctatcgaatt gacgaaagaa gtaaatgaga agattaattt
      721 tcttaaaaag aagattagtg catccattga taagaaaacc gccataacga gcattacggt
      781 caccttacaa aatccgcaga tcactgcggt tatagcagat tctgtcgttc ataaattaca
      841 ggaatatatt attgggtatc gaacttcaaa agtaaaagaa gactgtgcgt atttggaacg
      901 gttgtttaaa gaacgtcagc aggaatatta tgctgctcaa agaaaatatg cggattatgt
      961 agacgcccat gataatgtgg ttcttcaaag tgtacgtgct gagcaggagc gtttacagaa
     1021 cgacatgagt ttggcttatc agatatatag tcaggttgct aatcagttgc aggtatccag
     1081 agccaaagta caggaggaaa agccagtctt tgcagtagtt gagcctgccg ttgtaccttt
     1141 gaaaccttca ggtatgggac tcaaaattta tattttatta tttgtgttcc tgtccgtatc
     1201 tggtactctc gtgtgggtgt tttttggcaa aagtctgctg gctagcttga gaaaagaact
     1261 gaaaaataag gagatagaac aggataaatg atgctaaaac gtcgtttaca acattcttac
     1321 atcaattaaa ttcacttact atattattaa acgaatgata cgtacagcta tgataatggc
     1381 tgcgggcatg agaacccgtt ttggccaata tacagaattg atacctaaag ggttcgtcaa
     1441 agtgggaggt attccaatga tagttcgttc tattgatact ttgttatcat gtgacattga
     1501 gcgaattgta atcggtacag gatataaaca agaagtttat gaagaattga agacagacta
     1561 tcctatgctt gaaacctgtt ttagtcctcg ttatgctgaa acaaatagta tgtatacttt
     1621 atataatacg cgggagattc tgggcaatga tgatttttta ttgttagagt cagatttgat
     1681 ttttgagaaa caagcaataa tgagcttatt ggagtgtcct gcggcagatg caatgctaat
     1741 aactccagtg acaaagtttc aagatcagta ttatgtggaa catgatgata attttcgcct
     1801 ttcttcatgt tctgtcaata agaataaact aaacgctaaa ggcgaattgg tcggcatcca
     1861 taaactatcc ggttcctttt acaaaataat gtgtgctgat tatgcgagta ttgttgatga
     1921 acaacccaat ttgggatatg agtatgaatt actacgaata tcttgttctc aatctcctgt
     1981 ttatgtgcat aaagtagaag ggctgaaatg gtatgaaatc gatgacatat cagatttgga
     2041 atatgcagag aaatatattg ttccgtattg ttaattaaaa taatatatca aattatgagt
     2101 aagacagttt atattgggat gactgcggat attatgcatc caggacttat ccgcattatt
     2161 aatgaggcta ctaaatacgg tgatgttata attggtcttc ttacagataa agctattgcg
     2221 gagcataaac gccttcctta tctgacctat gaacaacgaa aagaggtagt tcagaatatt
     2281 aaaggcgtat gtaaagttgt tcctcaagaa gaatggagct atgttgagaa tctcaaacgc
     2341 attaaacctg actatataat tcatggtgac gactggaaaa ccgggccttt acgtgaagaa
     2401 cgtgtgcgcg tatttgaagt gatgaatgaa cagggaggaa aggttatcga aattccatat
     2461 actttgggaa ttaattcatc ttctttggat aaagatatta aggctatagg tacaacccct
     2521 gatgtacgtt taaaatcact tcgtcgtttg ataaatgcca aacccgtagt tcgtattttg
     2581 gaagctcatg atggactatg tggcttgata attgaaaatc aggaaatatt aaaaggggat
     2641 aagagggaag tatttgacgg aatgtggtct agtagcctta cggattcaac cagtaaaggt
     2701 aaacctgata ttgaggcggt tgatttaact acccgattgc aagatttgaa taatattctg
     2761 gagtgtacta ctaaacctat tatttttgat ggagatacag gtggtaaaat tgaacatttc
     2821 gtatttacag tacgcacttt agaacgtcat ggaatttcag ctataataat tgaagataaa
     2881 gttggattaa aaaagaattc attgtttggt acagatgtta ttcaaactca agatacaatc
     2941 gaaggtttct gtaataagat caaagcagga aaggcatctc agattactga tgattttatg
     3001 attatcgctc gtattgagag ccttatagcg ggaaagccgg taagtgatgc tttagagaga
     3061 gcttttgcat atgtccaagc gggagcggac ggtattatga tacatagcaa aaataagtcg
     3121 ggtgaagata taaaagaatt ttgtttggcg tttcgaaaac agtatgctca tgtacctatc
     3181 gtggttgtgc ctactacata tgatcatatt tatgagtctg aattgtgtga ttggggtgtg
     3241 aatataatta tttatgctaa tcatatgctt cgtgccgctt atcctgctat gatgaatgtc
     3301 gcaaagataa tattagagaa tgaacgtgct ttagaggtgc gcgaactgtg tatgcccata
     3361 aaagaaatat tggaactgat tccaggtact aaataaaaag aggaatatca ttatgttaag
     3421 cgtagaaaaa gtttatgaaa cgtttctgag tcatgacgtt gattttttta caggagttcc
     3481 agactcatta ctaaaaaata tttgtgccta tatcacagac catacttcac gtgagaaaca
     3541 tatcatagct gctaatgaag gtgcggctgt aggaattgct tcaggttatt atatggcatc
     3601 aggtaaggtt cctgtggttt atatgcaaaa ttccggcttg ggtaatactg ttaatcctct
     3661 gctgtctctt gcagatgaac aagtatacag ttttccaatg cttttgatga ttggctggcg
     3721 tggtgaaccg ggaacaaaag atgaacctca gcataaaaaa cagggtgagg taactttaga
     3781 tttgttgaaa gcaatgcgga ttccttatat aattcttgat tcaaatgaga atgatgcatt
     3841 tattcagctc catgatatca tacaatcagc aaaaactaag aatattcctc atgcaataat
     3901 tattcggaaa gatgtttttg gcaaatataa acttcaaaaa gagttcggat gtaattatcc
     3961 tttatctcgt gaggatgctt tgcaaatagt tgtggattat ctgcctgaaa attcagtggt
     4021 cgtttctact actggcaagc tttctcgtga gttatttgaa tatcgagaaa tgaaagagca
     4081 aggtcatgaa catgattttc tcacggtagg ctctatggga catagttcat caatctcttt
     4141 gggtattgct atagcaaagc aagatagacc tgtttattgc ttggatggtg atggagcatt
     4201 tattatgcat ttaggggcaa ttagtaacat tggcgattta tctcctaaaa actattatca
     4261 tattttgttt aacaatggtg ctcacgagtc tgtaggagga cagcctactt taggatttag
     4321 tttagatatt ccggctattg tccgggggag cggatataag catacttata ctgtttgtac
     4381 aaaagttgaa attgaagaag caatgaagca gcttccaaag ttatgtggtc ctgttttgtt
     4441 ggaaataaag gttaaaatag attctcggga gaatttggga cgtcccacga ctactcctat
     4501 agagaataag gagcatttta tggatttttt aaaataaata tattcgatga aaatagaaag
     4561 aaaaatatta ttaaatcctg ggcctgccac tactactgac agtgtaaaaa tggcacaagt
     4621 tgttccggat atttgtcctc gcgagaaaga attcgcaggt atgatgaaac aacttcggga
     4681 cgatttggtc agagttgctc atgggaattt ggaaaaacat accgctgtat tattttgtgg
     4741 ctcaggaacc atcaatattg atatatgtct aaattctctt cttcctgaag acaaaagggt
     4801 gcttatagtg aataatgggg catatagtac ccgtgctgta gaagtgtgtc aatattatgg
     4861 tttgcctcat attaatttgg aattttccgt ttacgaacgt cctgatttat cggtggtgga
     4921 aaatgtgttg caagaaaatc ctgatatagc tatggtttat actactcatc acgagacggg
     4981 tacaggaatt ctgaacccta ttcgcgagat gggcgctata gctcataaat atcaggctaa
     5041 atttgtcgtc gatactactt cttctttggg catgattcct tttgatatag agaaagataa
     5101 tgtggatttt tgtatggcat ctgctcaaaa aggacttcaa gcgatgacag gtctttcttt
     5161 tattataggc aatgaggaac agattaagtt ttcaaaaaaa tatcccaagc gttcttacta
     5221 ttgtaatctt tatttgcagt atgagaattt tgagagaaca ggtgaaatgc attttactcc
     5281 accggtacaa actatttacg ccactcgtca ggcattaaat gaatattttg aagtgggtga
     5341 agaagctaag tttgcccgtc acaaaagagt ttttgaggct attcattcag gtataaatga
     5401 aattggtctt aaaagtgtaa taaagcgtga atggcagtca ggactggttg tctcagttca
     5461 atacccagaa gatcccaact gggattttga gaaaatacat gattattgtt atgagcgtgg
     5521 atttacgatt tatccaggta agatatcaac tgaggatact tttagaatct gtgctttagg
     5581 agagatagaa gtagatgata ttgagaactt ctttaaagta ctaaaagctg cattaaatca
     5641 ttataacgtc acattaccga tgtcatgatt gcagaaatat tattgaagat tcgtcatttt
     5701 tatttttccc ttcgtggtat acacttccat ccggaaagtg ttatttctgg agtgcctatt
     5761 cgtagctttc gcttagtagg caaatatggc aatattaatt tgaggtgatg cattaggagt
     5821 tctttattct tataaaaagg catcggtagt tataggagat aatgtttgtg tagggtaatt
     5881 tgcttttagt gggagagacc atattagaat tgcggtaagg ggcgaagaag ataataacca
     5941 attagtgaga atattggaaa aatataattg atatcggtaa atgtagttgt ttttatactg
     6001 tatttaagta atggaaaatc taaagcagaa aactgtatca ggaataatgt ggagcgctat
     6061 agaacgtttc tctttacaag gagtacagtt tataattcaa ataatattag ctcgtttgtt
     6121 actaccatcg gattatggta tgatcgggat gttagctatt tttcttcaag tcgctcaagt
     6181 atttatagat agcggtttta caaatgcttt aatccagaaa aaagatagaa ctgaagagga
     6241 ttttgccact gtcttttatt ttaatattct tgtcgcagta ttattctatg gtatattgtt
     6301 tttttcggct tctttgattg cagactttta taatatgccg actttagttc ttgtaattcg
     6361 ttttatagca ttgtcgttga taataaatgc tttatcggct attcacagaa cgaaattaat
     6421 tatttctgta aactttaaaa ctcaatctaa aatttcatta ggtgcagctt ttatatcagg
     6481 cgtgattgga atatggatgg cttatgtcgg ttgcggggtt tgggctttag tttggcaaac
     6541 tctcttaaat agtataattt tgacaatttt gttttactgt ttagttcatt ggaaaccttt
     6601 acatactttc tccaaaagtt cttttgaaag attattcaat ttcggatcta aattattgat
     6661 ctcaagtctt atcaatacag tatatcgtaa tctgtatacc attgtaatag gaaaaaagtt
     6721 ttctgttgta gagcttggtt actatacaag agcagaacaa tttgctattt ttccttccaa
     6781 taatttaaat gctttagttt ctagagtagc gtatcctatt ttaagttcca ttcaagatga
     6841 tgataaatgt ttaacaaacg catatcgaaa ttatatcaga ttatcctcat atataatttt
     6901 tcctttaatg gtaggtttac ttgttttggc taatcctatt attagtctat tgttaacaga
     6961 taaatggtct ggggttgtta ttcttttaca gatattatgt ttggattgga tgtttgatca
     7021 tttgagccaa attaatttga atttattatg ggttaaagga agatctgatc tgtcgttacg
     7081 tcttgaaata ataaaaaaga cgattgctat attcattctt tttgtgtcaa ttccatttgg
     7141 gcttgaggtg atgtgttggg gtagagttat ttactctctg atagcgacat atttgaatac
     7201 atattatact aattctctta ttgatttgac cttaaagttg caagttaaag atgtatttcc
     7261 aagtttaata ctctctttca taatgggggg gatcgttttt atatgtattt ctttctttga
     7321 aactgatata gtaaaaattg tgattggatg tattactggg atgtccttct atattttact
     7381 ttcttttctt tttaagctag attctttttt ttgtatttta acattgatca ttaaaactaa
     7441 aaacatagat gaaaatatta aaaaagattt ttcaagtaat agtaaagata attaaccatt
     7501 gtgtgccagt tgatagtaga tcattgtatt ttattcctca tcctaattgt agaacagata
     7561 aatatgatat tataaattat tcgtcagata atgttctcgt tctgttaaat tatttgctaa
     7621 aaaaagatag tgctgaatat tataaaatat atgttgaaat ttatgattct tctcgtattt
     7681 cagaatatca agaatatatt tatggcataa atcctaatat taggtgtact tttttatgtg
     7741 catgtgttgg acgttttttc tttaataaag tatcttttaa ggatatgttg tatgcctttt
     7801 tttgtttttg tagagcaagt aaatgtttta cagctacttt ttattatgat ttttcattta
     7861 aaaaacgctc tcaacagatt atttgtttgg ggtattatac tccattcaaa gatgattatc
     7921 atatgggaga tcattcttat gataaatttc gtaatacaac atgtaactca tttgattact
     7981 ctattgctac ttcttgttta agtgctagaa taatttcaat agattgtgga atctcatatg
     8041 ataaattcaa agtcttagga tttcccagaa atgatttgtt gatatcgaaa aataattgca
     8101 atgttattaa aagagaaatt tcgaaatttg cgggatatga tgtaactaaa tatatagttt
     8161 atactccaac ttttcgtgat tatgagactg ttactgaagg taatttgcgt tcaatactcg
     8221 gatatgttga ttgtgatttg ttgaagttat cgaaaatact attgaagttt aatgcggctt
     8281 taattcttaa attacatcct ttgcagaata aaacagtctt aaaaaaagat ttacccaaag
     8341 gtatacttgt ttttgaacaa acatataaat atggattgta tgatcttttg tcattttcag
     8401 atggaatgat tactgattat acttctacct attttgattt tttattggta aataagccag
     8461 tcatatttaa tttctacgat attgaagaat atcgtagagt aagaggtttc tcatttgagc
     8521 caatagaatt tttttgtgca ggtgatattg tttacaatta taatgaattg atagatgctg
     8581 tgatgggact tctggctggg aaagatattc atgctgaaca tcgacgtcat atttctttat
     8641 tgatgaatca atttcaagat gataattcaa caaagagaat atgtgacata tttttaaatg
     8701 aaatataata aataaaatga attatgcatt tgtggtgcag gcacgtttag gttctacacg
     8761 tttgcctgga aaaatattga aacctttcta tggtaatcaa tcgattcttg acttaatggt
     8821 tcataagctt tctgctatat cgaatattcc agtaattatt gctacaacaa attctgttat
     8881 caatgaacct attgaaaaga aggcacttgc attaggggta aagtgcttca gaggtgagga
     8941 gaatgatgtt ttaaaacgat tcattgatgt tgctgaatat tttgatatac agggtatatt
     9001 ccgaatatgt tctgataatc catttttaga tgtacatgcg gcaaggcaat tggtcgaaat
     9061 agcaatgaaa tcttgtaacg attatataag ttttgatatt gatggtactc catcaattaa
     9121 aactcatttc ggtttttggg gagaatttgt aacgcttgat gcgctgaagc gagttatagg
     9181 atttactgat gatttattgt atcgtgaaca tgttactaat tatatatata gtcatcctga
     9241 actttttaat attcaatgga tttcaggatc tccagtcgtg tcaaaacatc ataatattcg
     9301 actcacgatt gatacgttag aagatttttc tgtagcacag agaatatata gggatttaca
     9361 agaaaaaaga gtggaaatat cgatagaagt gattgtagac tatgttcgaa gacatgcaga
     9421 atacattcaa ctgatgaaac aacaaataaa aaaaaattct aaataatgaa gaatacttat
     9481 attattggtg aaatagggca gaatcataat ggttctgttg acttggctaa gttgattatt
     9541 gaattaatct cacgacctgt acatgaggat gtttttggta tggatttcat gccaatgaat
     9601 gctgttaaaa tgactaaaag agatttatca gaagaattgg ctgtttctca aatgaatcaa
     9661 atatatgaca atcctaattc ttttgggcgt acttatggtg aacatcgtgc ttttcttgag
     9721 cttgatgatc aagcgcattt tgagatttat aaatatgcta agtcattagg attagatttt
     9781 atcgagacgt tatgtgccaa aggatgtctg tctttgctta aactgttcac accggatagg
     9841 ctaaaagttg ctagtcgtga tttgactaac ttaccattgc ttgaagcatt agcagaaact
     9901 catattccta ttatattatc gacaggaatg gctggtcaaa gagaacttga caatgcatta
     9961 gatgtgataa cgagatatca tagtaatata gctattctac attgtgtatc tcagtatcca
    10021 actcatccaa ataatttgaa tctacgtaca ataacatatt tgaagaagca ttacaataag
    10081 tttgagatag gtttttctga tcatacaata ggtatttctg ctgctacagc tgctgtagcg
    10141 atgggagcgg aaattataga aaagcatgta acaattgatc ggcatatgaa aggaacagac
    10201 cagcttggct ctttaggtcc agatggggtt aatcgtatga ttcgagatat tcgcatagca
    10261 gagtgttggc ttggtactga agatctttat atagaaaaag gggtggagaa gtctaagata
    10321 aaacttgaac gttctattgc cactcgaaaa tatattccag caggtagtat tattcaagag
    10381 tcggacattc atttactgag tcctggtgat ggttataaat ggatagataa aaaaaatgta
    10441 attggtcatt ttgctaaaca agatatatca gcgaatgaaa taatatatcc tgattttatt
    10501 gaatagatat attcctactg caacttgtat tacggtatag agtactgcct gctataagct
    10561 aagtagtgat taataaataa gggtaaaata ctaaaaaaat gaaagagata aagcttatac
    10621 ttacagatat tgatggcgtt tggactgatg gcggaatgtt ttatgatc
//
