LOCUS       c00063_gnlPro..        14940 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NIGGGDOP_63.
ACCESSION   c00063_gnlPro..
VERSION     c00063_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 18:45:44
            Original ID  :: gnl|Prokka|NIGGGDOP_63
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14940
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14940
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1426:4940]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1427..4940
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..14940
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14940
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             complement(2..124)
                     /locus_tag="ctg63_1"
                     /transl_table=11
                     /translation="MKLLGTTVDFVHMTARCTSLIMVDLFISNSCYVLTRNITNP"
     CDS             356..1306
                     /locus_tag="ctg63_2"
                     /transl_table=11
                     /translation="MEERILFSQKTTIFVPVDNDSRIKPMSKDSLCAQHTDCSGCPKAM
                     ESTLIHRNLLRGQHIPKDKCTQNCMLFMIEGELLINSDEHPGTTLHEKQFILQAIGSKY
                     EILALTDVSYILFWFNELPLLCENRYREIIDQAEGPLTYTPMVMNPRLFYLINDVAAYL
                     DESTPACGKYIDLKCQEMVYMITNYYPLPQLRAFFYPISTYTESFQYFVMQNYSKAKNV
                     EEFAHLGGYNTTTFRRLFRNLYGVPVYEWMLEKKREGILEDLQHSNMRITEICNRYGFD
                     SLSHLAHFCKDSFGDTPRALRKKAANGEKIGKITD"
     CDS             1427..2131
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg63_3"
                     /sec_met_domain="SucD_FumR (E-value: 2.5e-130, bitscore:
                     425.5, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWLSNSSVGRKVVMSVTGIALVLFLTFHMAMNLVAIISADGYNMI
                     CEFLGANWYALVATAALAALFIIHIIYAFWLTMQNRTARGSERYAVVDKPKTVEWASQN
                     MLVLGIIVIVGLGLHLFNFWAKMQLPELMHNLDMHADTLTLAYAANGAYHIQQTFSCPV
                     YVVLYLIWLFALWFHLTHGFWSSMQSLGWNNKVWINRWKCISNIYSTIVVLGFALVVVV
                     FFVKSLLCGGAC"
     CDS             2169..4148
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 200.6; E-value:
                     1.5e-61)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg63_4"
                     /sec_met_domain="FAD_binding_2 (E-value: 4.7e-61, bitscore:
                     200.6, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 1e-35, bitscore:
                     116.1, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKIDSKIPEGPVAEKWTNYKAHQKLVNPANKRRLDIIVVGTGLA
                     GASAAASLGEMGFRVFNFCIQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTVKG
                     GDYRAREANVYRLAEVSNAIIDQCVAQGVPFAREYGGTLDNRSFGGAQVSRTFYAKGQT
                     GQQLLLGAYSALSRQVNVGTVKLFTRYEMQDVVIIDGRARGIIAKNLITGELERFAAHA
                     VVIATGGYGNAYFLSTNAMGCNCTAAISCYRKGAVFANPAYVQIHPTCIPVHGDKQSKL
                     TLMSESLRNDGRIWVPKKKEDAIKLQKGEIKGSDIPEEDRDYYLERRYPAFGNLVPRDV
                     ASRAAKERCDAGFGVNNTGLAVFLDFSEAINRLGIDVVLQRYGNLFDMYEEITDVNPGE
                     LAKEISGVKYYNPMMIYPAIHYTMGGIWVDYELQTTIKGLFAIGECNFSDHGANRLGAS
                     ALMQGLADGYFVLPYTIQNYLADQITVPRFSTDLPEFAEAEKAVQAKIDKFMSIQGKES
                     VDSIHKKLGHIMWEYVGMGRTAEGLKKGIAELKAVRKEFETNLFIPGSKEGMNVELDKA
                     IRLYDFITMGELVAYDALNRNESCGGHFREEYQTEEGEAKRDDENFFYVACWEYQGDDE
                     KAPVLIKEPLVYEAIKVQTRNYKS"
     CDS             4185..4940
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg63_5"
                     /sec_met_domain="Fer4_7 (E-value: 1.4e-11, bitscore: 38.5,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer2_3 (E-value: 1e-24, bitscore: 80.3,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 6.2e-06, bitscore: 20.2,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKNISFTLKVWRQAGPKAKGAFETYQMKDIPGDTSFLEMLDILN
                     EQLISERKEPVVFDHDCREGICGMCSLYINGHPHGPATGATTCQIYMRRFNDGDTITVE
                     PWRSAGFPVIKDLMVDRTAYDKIMQAGGYVSVRTGAPQDANAILIPKPIADEAMDAASC
                     IGCGACVAACKNGSAMLFVSAKVSQLNLLPQGKPEALRRAKAMLSKMDELGFGNCTNTR
                     ACEAECPKNISISNIARLNRDFIIAKLKD"
     CDS             5101..6330
                     /locus_tag="ctg63_6"
                     /transl_table=11
                     /translation="MNKLLLIWIVVLLTSCITNQENARDTLFVNLTDATDSQSLKLSDF
                     GNTVRYVPLETNEVCLIGNNPHIALLEDKIVIATKDQCFLFHKQTGKYICSIGHIGDDP
                     SGYSSTNYWIDDAGLFYFFRAPDQLLKYNQKGEMTGKIQIPHIPAAPDFFAFSDSTIIA
                     HCNSSIGLESSNSLLFLNSFGEKLDSIPNLLKSPSIPSPDNISSLSIIKRGAGFFGNLG
                     RRGVMIIKDKEQGELLLPLYNPSLWSSENEVRFRETFTDTIYTVKNRKLYPYMVFHTDT
                     DHSSANPLWYSNPQSIYVAYVLENTHSVFFQYVKNKQVYNGLYNKETQQTKFAKCQQFI
                     VDDLTSEQELKVDLSALCSYKGEYGFILEAASIPDASQKQSDNKNENIPHWMSQLDEDA
                     NPVIAIVSDK"
     CDS             complement(6402..7928)
                     /locus_tag="ctg63_7"
                     /transl_table=11
                     /translation="MRTKRAFKEFCVLGGLASSVCGVAQERPNIIVFLVDDMGLMDTSV
                     PFIADESGQPVRHPLNDWYHTPNMERLAKQGICFSTFYAQSVSSPSRASIMTGQNATRH
                     GVTNWINAESNNRNPFGPPQWNWKGLRKDMPTMPRVLQQAGYKTIHVGKAHFGCMGSEG
                     ENPLNIGFDVNIAGSGIGHPGSYYGEWGYGHIKGQKIRAVPDLEKYHGTDTFLSEALTI
                     EANREITKAVEEKRPFYLNMAHYAVHSPFQADKRFLSRYTDPDKNEQARAFATLIEGMD
                     KSLGDIMDQLEKLGIAENTLILFLGDNGGDAPLGDERGYGSSAPLRGKKGTEFEGGMRV
                     PFIAAWAKPEKKSKVQKNLPIEVGSMQTQLGTIMDIYPTVLSVAGCEVPQNYVIDGFDL
                     KKQLSGKVDKKRPESFLMHFPHAHRGSYFTTYRMGDWKLIYYYLPETPKQPKALLYNLK
                     DDPEERNELSAAHPDQCREMIREMSARLEKEGALYPVDKQGNELKPFVYF"
     CDS             complement(8276..9118)
                     /locus_tag="ctg63_8"
                     /transl_table=11
                     /translation="MSSICQGTWDCQNCPKAVDNAIIHTTHTRGYHQPARKCEDNFILF
                     LIKGELLVNSQEYAGTMLKAGEFILQAIGSKYEMLAMTECECIYYRFIQPELFCDFRFN
                     HIMKDVPSPLIYSPLKIIPELKYFLDGSKSYLSESKVCRDLLSLKRKELAFVLSYYYSD
                     YDLASLVHPLSKYTTTFEYFILQNYKKVKTVEELAQLGGYTVSTLRRIFNNVFHEPVYE
                     WMQARRKEGILDDLNNSEYSISEICYKYGFESLPHFSNFCKKFFGASPRMLRTSKKNV"
     CDS             complement(9459..10442)
                     /locus_tag="ctg63_9"
                     /transl_table=11
                     /translation="MKKVLLAIAAVATITSCSQNEEFENPAQNAEINFSTIVSKSTRAV
                     IIENKDFKKFTAYGYSHGETNFTGVVTSTIMSSAEYTKGEDGGWTTSGRYYWPTSGKVT
                     FFGYGGVATATYAKEDGKFPTLKYTVLTDVNKQEDLLVAQQANKSKENNNPSVNLNFKH
                     ALAQVYFKLKGNDADLTYTVSKIELNKVRTEGTFTYGGDPDTSIGQWAVEDNASTGNYA
                     ITLNDQKVIGEAEATILNDALTQVMILMPQSLAGVEVKVTYSAEKGGLEVHSASEPVTV
                     KLTGNWEAGSKTAYVLSLNGDAINLTGSSDDTSWSEKTDVNTDVNK"
     CDS             complement(10495..11451)
                     /locus_tag="ctg63_10"
                     /transl_table=11
                     /translation="MQDTRYILLVLLSSLLMLTGCSRRELLDDYPVSGVDIKLDWNGVT
                     DKLPEGVRVIFYPKSAEGRKIDTYLSVRGGKVKVPPGRYSVVAYNYDTETVQIRGEEAY
                     ETIEAFTGYCNGLGIAGTEKMVWGPDPLYVVQINDLHIANSEEELLLDWKPKLVVKTYS
                     FKIKVEGLEYVSSIVGSVEGMAGCYCLGRCCGMMNDAPIYFEAQGCSGEVTGSFTAFGL
                     PEGAMSRASLAIKFTLAFVKVDNTVQKIEVDITDVIVNSESGEGGGNDEPSKDIELPLD
                     DDEVKVDKPENSSGGDGGIGGDVGDWGEEEEVPLPVI"
     CDS             complement(11459..12742)
                     /locus_tag="ctg63_11"
                     /transl_table=11
                     /translation="MKNGIYTCVILMAFLALSESVYAAIPVLTVASDTIRRVVIYFDKE
                     ETDIDFSYKTNNHEINVLDSLLEEKINSRYITALNVVTFVSPDGDSVYNAALSVRRNNS
                     MREFLRQRYPYVDVEKIKLTSEGEDWSELRKLVASDSDLPDREEVLMLIDYHRDNTVKR
                     KELLQKLNQGMAYRYIVRNVLPELRRAEITVVREVPEMEKNTFEPVSSVFGLFVSKQEE
                     ALPSDQPDKPEGESKESMAYEDEVVVSEAEGPVESKTVLAVKNNLLYDLALAPNLEVEI
                     PVGKRWSLNAEYKCPWWLNSKHDFCYQLLSGGVEGRCWLGNRQKRNRLTGHFIGLYAEG
                     GIYDFQWKGDGYRGDYYGAAGVTYGYARQLARHLSLEFSFGIGYLTTEYKKYTPYEGDI
                     VWTTSGRYNFIGPTKAKVSLVWLIKRGR"
ORIGIN
        1 cagggttagt aatatttcta gtcaacacat agcagctatt agagataaac aagtcaacca
       61 ttattaggga agtacatcga gctgtcatat gaacgaaatc gacagttgtt ccaagaagtt
      121 tcattacttg aaacagtttg tttcatgcct tgaaacactt ggtttcaaca ggtggaacta
      181 atgatgaaac tacttgttct gaatatatca tgtaaaggga tgaagaaaat gctgcagatg
      241 gcagataaaa atgtattaat gtattaaaga acgccattca ggagtccgtg aaacttcaaa
      301 gttgtgcaaa caaaaccaat aaagacaatc atatccccgt ttctgctaaa acataatgga
      361 agaaagaatt ttattttcac aaaaaacgac tatctttgtc cctgtagaca acgattcacg
      421 gataaaaccc atgtcaaaag actcactttg tgctcaacat acagattgct caggatgccc
      481 caaagcgatg gaaagtactc ttattcacag aaatctgctc agagggcagc atattccgaa
      541 ggataagtgc acgcaaaact gcatgctctt tatgatcgag ggcgaattgc tgatcaacag
      601 tgacgaacat cccggaacga cactacacga gaaacagttt atcctgcaag ccatcggctc
      661 aaaatacgag atactggcac tgacggacgt atcatacatc cttttctggt tcaacgaact
      721 gccgttgcta tgcgaaaacc gctaccgtga aatcatcgac caggcagaag gcccgctgac
      781 ctacacccca atggtgatga acccgcgcct gttctatctc atcaacgacg tagccgcata
      841 ccttgacgaa tcgacacccg cctgcggcaa atatatcgac ctgaaatgtc aggagatggt
      901 gtatatgatc accaattact atcccctgcc ccagttgagg gctttcttct acccgatcag
      961 cacctatacg gaaagtttcc aatactttgt catgcagaat tacagcaaag cgaagaacgt
     1021 cgaagaattc gcacatctgg gaggctataa caccaccacc ttccgccgtc tcttccgaaa
     1081 cttatacggc gtgcccgtct acgaatggat gctggagaaa aaacgggaag gcatcctcga
     1141 agacctacag cactctaata tgcggattac agagatttgc aaccggtatg gtttcgactc
     1201 gctgtcccac cttgcacact tctgcaaaga ctccttcgga gacaccccgc gcgccttgcg
     1261 caagaaagcg gccaatggcg aaaaaatcgg aaagatcacc gattaaggaa ttatttcttt
     1321 aattctttgg tcaatcaatc tatttcccct atttttgcag tctgtaagag gtgtaaaacg
     1381 tcgaaatttt agttctaaca attaaataat ttaaattcaa tcatttatgt ggttaagtaa
     1441 ttcatctgta ggaaggaaag tggtgatgag cgttaccggt atcgcccttg tcctgtttct
     1501 aacatttcac atggcgatga acttagttgc aatcatctcg gctgatggtt acaacatgat
     1561 ttgtgagttt ttgggagcaa actggtatgc gctggtagct accgcagcac tggctgctct
     1621 tttcattatt cacatcatct acgcgttctg gctgacaatg cagaatcgca cagcgcgcgg
     1681 tagcgaacgc tatgcagtag tcgacaaacc gaaaactgta gagtgggctt ctcaaaacat
     1741 gttggtgtta ggcattatcg ttatcgtagg cctcggtttg cacctcttca acttctgggc
     1801 aaaaatgcag ttgccggaac tgatgcacaa cctggacatg cacgctgata cactgacgct
     1861 ggcttatgcg gcaaacggtg catatcacat ccagcagaca ttctcttgtc cggtttatgt
     1921 agtgctctac ctcatttggc tgtttgctct gtggttccac ctgactcacg gtttctggag
     1981 ctccatgcaa tcactgggat ggaacaacaa ggtatggatc aatcgttgga aatgtatttc
     2041 taacatctat tctacgattg tagtactcgg tttcgcactc gtagtagtgg tattcttcgt
     2101 gaaatcactc ctttgtggcg gtgcttgcta aatagtaaat tgtaaatgat taaattgtaa
     2161 ataatattat gatcaagata gattcaaaaa ttccagaagg cccggtggct gagaaatgga
     2221 ccaactataa agctcaccag aaattggtga accccgctaa taaacgccgt ttggatatca
     2281 tcgttgtggg tacgggtctg gcaggtgctt ctgctgctgc atccctcggt gaaatgggtt
     2341 tcagagtatt caacttctgt attcaggact ctccgcgccg tgcacactct atcgctgcac
     2401 agggtggtat caatgctgca aagaattatc agaatgatgg tgactccgtt taccgtctgt
     2461 tttacgatac agtaaaaggt ggtgactatc gtgcacgtga agccaacgtt taccgtctgg
     2521 ccgaagtgtc caacgctatc atcgaccaat gcgtggcaca aggtgttcct ttcgcacgcg
     2581 aatacggcgg tacactggac aaccgttctt ttggtggtgc acaggtatca cgtacgttct
     2641 acgctaaagg ccagaccggt cagcagctgt tgctgggtgc ttactccgca ctaagccgtc
     2701 aggtaaacgt aggtacggtg aagttgttca cccgttatga aatgcaggac gttgtaatca
     2761 tcgacggacg tgctcgcggt atcatcgcca agaacttaat caccggcgaa ctggaacgtt
     2821 tcgctgctca cgccgtagta atcgctaccg gtggttacgg taacgcttac ttcctgtcta
     2881 ccaacgctat gggttgtaac tgtacagctg ctatctcttg ctaccgcaag ggtgctgtat
     2941 tcgctaaccc cgcatacgtt cagattcacc cgacttgtat cccggtacac ggtgacaagc
     3001 agtccaaact gactctgatg tccgaatctc tgcgtaacga cggtcgtatc tgggttccga
     3061 agaagaaaga agacgctatc aaattgcaga aaggcgaaat caagggaagc gatattcctg
     3121 aagaagaccg cgactattat ctggaacgcc gttatccggc attcggtaac ctggttccac
     3181 gtgacgttgc cagccgtgca gctaaagaac gttgcgacgc aggtttcggt gtgaacaaca
     3241 caggtctggc cgtattcctc gatttctctg aagctatcaa ccgcctgggc atcgatgtag
     3301 tgcttcagcg ttatggtaac ctcttcgata tgtatgaaga aatcactgac gttaatccgg
     3361 gcgaactggc aaaagaaatc agtggtgtga aatattataa tccgatgatg atttatccgg
     3421 ctatccacta cacaatgggt ggtatctggg tagactacga actgcagact accatcaagg
     3481 gtctgttcgc tatcggtgaa tgtaacttct ccgaccacgg tgcaaaccgc ctcggtgctt
     3541 ccgcattgat gcaaggtctg gccgacggtt acttcgtatt gccttacact atccagaact
     3601 atctggcaga tcagattact gttcctcgtt tctctactga ccttccggaa tttgccgaag
     3661 cagaaaaggc agttcaggct aagatcgaca agttcatgag catccagggt aaagaatcag
     3721 ttgattctat ccacaagaaa ctgggtcaca tcatgtggga atacgtaggt atgggacgta
     3781 cggcagaagg cctgaagaaa ggtatcgccg aactgaaagc agtccgcaag gaattcgaaa
     3841 ccaatctgtt tatccccggt tctaaggaag gtatgaacgt tgagctcgac aaggctatcc
     3901 gtctgtatga cttcatcact atgggcgagc tcgttgctta cgacgcattg aaccgtaacg
     3961 aaagttgtgg tggtcacttc cgtgaagaat accagactga agaaggagaa gcaaaacgtg
     4021 atgacgaaaa cttcttctac gtagcttgct gggaatatca gggtgacgat gaaaaggctc
     4081 ctgtattgat caaagaaccg ctggtatacg aagctatcaa ggttcagacc cgtaactaca
     4141 agagctaatc ggtgaagtta aacatttaaa agaattagac gaaaatggat aaaaatatat
     4201 catttacact gaaggtatgg cgtcaagcag gcccgaaggc taaaggcgct tttgaaacct
     4261 accaaatgaa agatatcccc ggtgatactt ccttcctcga aatgctggat attctgaacg
     4321 aacagctgat cagcgaaaga aaagaaccgg ttgtattcga ccacgactgc cgcgaaggta
     4381 tttgcggtat gtgttctctt tacatcaacg gacatccgca cggtcctgca acaggtgcta
     4441 ctacttgcca gatttacatg cgtcgtttca acgatggtga caccatcact gttgagcctt
     4501 ggcgttcggc cggtttccct gtcatcaagg acttgatggt agaccgtact gcttatgaca
     4561 agatcatgca ggccggtggt tatgtaagcg ttcgtacagg cgctccgcag gatgccaacg
     4621 ctatcctgat cccgaagccc attgctgacg aagctatgga tgccgcttct tgtatcggtt
     4681 gcggtgcttg tgtagctgct tgtaagaatg gttctgccat gttgttcgtt tcggcaaagg
     4741 tcagccagtt gaacttgctt ccgcaaggta aaccggaagc tctgcgccgt gcgaaagcta
     4801 tgttgtccaa gatggacgaa ctcggattcg gtaactgtac caacacccgc gcttgcgagg
     4861 ctgaatgtcc gaagaacatc tctatcagca acatcgcccg cctgaaccgc gacttcatca
     4921 tcgctaaact gaaagactaa gcgtgagctt gatttgatta atagcataaa tcccccgtcg
     4981 gcgttagctg gcgggggatt tctttttact gaccaattat ttatagatag cttgttcatt
     5041 atccgttttt tattcttttc tttgtgacat aaggccagac aatcaaataa attaaatacg
     5101 atgaataaat tattgctgat atggatagta gtcttactaa cctcatgcat cacaaatcag
     5161 gagaatgcca gggatacatt atttgtaaat cttacggatg caactgattc ccaaagccta
     5221 aagttatctg acttcggaaa tactgtacgt tatgtacctt tggaaaccaa cgaagtatgc
     5281 ctgataggaa acaatcccca tatagcgctg ctggaagaca agattgtgat tgctactaaa
     5341 gaccaatgtt tcttattcca caaacagacc gggaagtata tatgcagtat aggccatatc
     5401 ggtgatgatc caagtggata tagctcgaca aattactgga tagatgatgc aggtcttttt
     5461 tacttctttc gcgcaccgga ccagttgcta aaatataatc agaaaggaga aatgaccggg
     5521 aaaattcaaa ttccacatat acctgccgca cccgactttt tcgcgttttc cgactctacc
     5581 attattgccc attgtaatag tagtatagga ttggaatcca gcaactcttt gcttttcctc
     5641 aactcctttg gagaaaagct ggattcaatt cccaatttat taaaatcgcc ctctatccct
     5701 tctccggata atatatccag cctttctatc ataaaaagag gagcaggttt ctttggaaat
     5761 ctgggaagaa gaggggtaat gattatcaaa gataaggagc aaggagaatt actgctgcct
     5821 ctctataatc ccagcctatg gtcgtccgag aatgaagtac gtttcagaga aaccttcaca
     5881 gacacgatat acacagttaa aaacaggaaa ctatatccat atatggtttt tcatacagat
     5941 acagatcatt catccgccaa tcctttatgg tatagtaatc cgcaaagtat ctacgtagct
     6001 tatgtattgg aaaacacaca ttctgtattt tttcaatacg taaaaaacaa acaagtctat
     6061 aatggtttgt ataataaaga aacacagcaa actaagtttg caaagtgcca gcaattcatt
     6121 gttgacgatc tcacttcaga gcaggaactg aaagttgacc tgtcggcatt gtgcagttat
     6181 aaaggagaat atggatttat tctggaagct gccagtattc ctgatgcttc tcaaaaacaa
     6241 tctgacaata aaaatgagaa tattccccat tggatgagcc aattggatga ggatgccaat
     6301 ccggtcatag caattgtatc tgacaaatga tatataattc tgtctgtttt gcctaataga
     6361 tatgctttgg caaaacagac agttgaaata gtagcaccta tttaaaagta aacaaaaggc
     6421 ttcaactcat ttccttgttt atccaccgga taaagagctc cttccttttc tagccgggcg
     6481 gacatttccc gaatcatctc tctgcattga tccggatgtg cggcagacag ctcattcctt
     6541 tcttccggat cgtctttcag attataaagc aaggctttgg gttgtttcgg agtctcggga
     6601 agataataat aaatcagttt ccagtcgccc atgcgatagg tggtgaagta gctgccgcgg
     6661 tgtgcgtgag ggaagtgcat caggaaagac tcgggacgct tcttgtccac cttaccgctc
     6721 agttgctttt tcagatcgaa tccgtctatc acgtagtttt ggggaacttc gcatcctgcc
     6781 acagacagaa cagtcggata gatatccatg attgtgccca actgtgtctg catacttcct
     6841 acttcaatag gcaagttctt ctgtactttg ctcttcttct caggctttgc ccaagctgcg
     6901 atgaaaggaa cacgcatacc accttcaaac tccgtcccct ttttacctct cagcggagcg
     6961 gaagaaccat agccacgttc atctcccaat ggagcatcac caccgttatc tcctaaaaag
     7021 agaatcagcg tattttcggc aattcccagc ttttcgagtt ggtccatgat gtcgcctaat
     7081 gatttatcca tgccttctat caatgtagca aaagctcttg cctgctcgtt cttatccggg
     7141 tcggtgtagc gtgacaagaa acgtttgtct gcctggaaag gtgaatgaac tgcgtaatgg
     7201 gccatattca gatagaaagg tcgtttttct tctacggctt tggtgatctc ccgattcgct
     7261 tctatagtca gcgcttcact caggaaggta tctgtaccgt gatatttctc caggtcagga
     7321 actgctctaa tcttctgtcc cttgatatgc ccgtatcccc attcgccata atagctgccg
     7381 ggatgtccaa tgccggaacc tgcgatattt acatcaaagc cgatattcag cggattctct
     7441 ccttcgcttc ccatacagcc gaaatgtgct tttcctacat gaatggtttt atatccggct
     7501 tgttgcagga ctctcggcat ggtaggcata tcttttctga gacctttcca gttccattgg
     7561 ggcggtccga aaggattccg attgttgctc tcagcattaa tccagttagt gactccatgc
     7621 ctggtcgcat tctgtccggt catgatggaa gctctggaag gggaactcac gctctgtgcg
     7681 taaaaagtag aaaaacaaat accctgttta gccagtctct ccatattcgg ggtatgatac
     7741 cagtcattca gcggatgacg caccggctga ccactctcat ctgcgataaa aggaaccgac
     7801 gtatccataa gtcccatgtc atctacaagg aaaacaataa tattcgggcg ctcctgagct
     7861 actccgcaaa cggaagatgc caaaccaccc aatacacaaa attccttaaa agctcgtttt
     7921 gttctcatta catagtattt atgatttata tcctagttat tgtacgtgcc ataatagatt
     7981 tcaaactcag actctcttct gattacacaa aagagtatta gaaaaatatc ctattatctt
     8041 tcattcattc agcataatct atcatgttat tattctgctt tgaaacctga ttttaattcg
     8101 ttgaaataaa aagtttaatt tccgtatccg ccttatcatg gctttatttg aagtgatctg
     8161 actttataat aaagatgtat tagactggtt ttaaaggaaa cagctagcaa tatacaacaa
     8221 atgtactaca cccacaaaga aaaaaatagt ttttgacttt ctctctgaaa aattatcaga
     8281 cgttcttctt gcttgttcta agcatacgtg gagaagctcc aaagaacttc ttacagaaat
     8341 tggagaagtg aggcagagac tcaaaaccgt atttatagca tatttcggag atactgtact
     8401 cagagttatt caagtcatcc aaaatacctt ccttacgtcg cgcctgcatc cattcgtata
     8461 ccggttcgtg gaatacatta ttgaagatac gccgcaaggt gctgacggta taacctccca
     8521 gttgagccag ttcttctacc gtttttactt tcttatagtt ctgaaggatg aagtattcaa
     8581 aagtggtggt gtatttcgag agtggatgca ccaaactagc caagtcataa tccgaataat
     8641 agtagcttag cacaaacgcc agttctttgc gctttaaaga cagcagatcc cggcagactt
     8701 tactttcact caaataggat ttggaaccat ccaaaaagta tttcaattca ggaattatct
     8761 ttaaaggaga atagataagc ggagaaggta catccttcat gatatgattg aaacggaagt
     8821 cacagaatag ttccggctga ataaaacgat aatagataca ttcgcactcg gtcatcgcaa
     8881 gcatctcgta ttttgaacca atagcctgaa gaataaattc acctgctttc aacatcgtac
     8941 ctgcatactc ctgactatta accaagagct ctccctttat caaaaaaagg atgaaattat
     9001 cttcacactt ccgggctggt tgatggtagc cccttgtatg ggtagtgtga atgatagcat
     9061 tgtctacggc tttcggacag ttctgacaat cccaagtacc ctgacagatt gatgacatat
     9121 atttgtgttg gcgtttgatt tgttcctgtt tgcaacaaaa atatatgaaa tcttttacat
     9181 ggcaatagaa aagggaggaa aagtgaaaaa gaggttattt ttacattttt tttgtaatat
     9241 aaaaaggaga gtatttttac ttttaaaaaa gctattcact attttatatt atcaaaaatt
     9301 cctaaatata aattttacac tagattttga ctttcaaaca taactagaat taatttaaaa
     9361 ttaggggact atctgaaata tcatcagata aagtccccgg aatattttat tttcaaataa
     9421 tcaaaacaga catttgtttc ttaataaata cgtccaaatt atttatttac atcagtattt
     9481 acatctgttt tttctgacca tgaagtgtca tcagaagacc ctgtcaaatt tatagcatca
     9541 ccatttaaag ataatacata agctgtttta gaaccagctt cccagttccc tgtcaatttt
     9601 accgtaacag gttcactcgc actatgaact tcaaggccac ccttttctgc actatatgtt
     9661 actttaactt ctactccggc taaggattgg ggcataagaa tcattacctg tgttaaggca
     9721 tcatttaaaa ttgtggcttc tgcttctcct ataactttct gatcatttaa tgtgattgca
     9781 taatttccag tagaagcgtt atcctctaca gcccactgtc caatagatgt atcaggatca
     9841 cccccatatg tgaaagtacc ttctgttctt accttattta gttcaatctt agaaactgta
     9901 tatgtaaggt ctgcgtcatt acctttcaat ttaaagtaaa cttgagccaa tgcatgctta
     9961 aaattcaaat taacagaagg attattgttt tctttacttt tattagcttg ctgtgctact
    10021 agtaagtctt cttgcttatt aacatccgtt aacacagtat attttaaagt aggaaactta
    10081 ccgtcttctt tagcatacgt tgcagtagcc actcctccat atccaaagaa agtaacctta
    10141 ccagatgtcg gccaataata acgccctgat gtagtccagc ctccatcttc acctttagta
    10201 tattcagcac tagacattat agtagatgta acaactcccg taaaattcgt ttcaccatga
    10261 gaatacccat aggctgtaaa tttcttaaag tccttattct ctattataac ggctcttgta
    10321 gatttactta caatagtact aaaatttatc tccgcattct gtgctggatt ctcaaattct
    10381 tcattctgtg agcagcttgt aattgttgca actgctgcaa tcgccaataa tacctttttc
    10441 ataatcgtat ttttttaagt ttataatatt gttatatttt gcttatgctt tatctcaaat
    10501 tacgggcaaa ggcacctcct cctcttcccc ccaatcacca acatcaccgc caataccacc
    10561 atcaccacca gacgaatttt ccggcttatc aaccttcacc tcatcatcat caagcggtaa
    10621 ctctatatct ttagaaggct catcgttgcc tcccccttca ccactctccg aattaacaat
    10681 cacatccgtt atatcaacct ctatcttctg taccgtatta tccaccttca caaatgccag
    10741 cgtaaacttt atagcaagac ttgcccgact catcgcccct tccggtaacc caaaagcagt
    10801 aaaactaccc gttacttcgc ccgaacaccc ttgcgcttca aagtagatag gagcatcgtt
    10861 catcatcccg caacatctgc ccaaacagta acaacccgcc ataccttcca cactgcctac
    10921 aattgaagaa acatattcca gcccttccac cttgatcttg aaagaatagg tctttaccac
    10981 taatttcggt ttccaatcca gtagaagctc ttcttcactg ttcgctatat gtaaatcatt
    11041 gatctgcact acgtataagg gatcaggtcc ccataccatt ttttccgttc ccgctattcc
    11101 cagaccattg caatagcctg taaatgcttc aatcgtctca taggcttcct ctcctctgat
    11161 ctgcaccgtt tcagtgtcgt agttgtaagc cactaccgag taacgccccg gcggcacctt
    11221 tacttttcca cctcttactg aaaggtatgt atcaatcttt ctgccttccg cactcttcgg
    11281 ataaaaaatc acccgaaccc cttccggcaa cttatcggta acaccgttcc aatctaactt
    11341 tatatctacc ccgcttacgg gataatcatc caatagttcg cgacggctac atccggtcag
    11401 catcagcagc gaggacagaa gcacaagaag tatgtatctt gtatcttgca taacgtcctt
    11461 atctccctct ttttatcagc cataccagag agactttcgc cttggtagga cctataaagt
    11521 tataacgtcc actagttgtc cacacgatat ccccctcgta aggagtatat ttcttatatt
    11581 ctgttgtcag atacccgatg ccgaagctaa attcgagcga cagatggcga gccagttgcc
    11641 gcgcataccc gtaggtcact cccgcagctc cgtaataatc gccccgataa ccgtctccct
    11701 tccactggaa atcgtaaatt ccaccttcag cataaagccc aataaaatgc cctgtcaacc
    11761 ggttgcgctt ctgacgattg cccaaccagc aacgtccttc cactcctccc gaaagaagct
    11821 gataacagaa atcatgttta ctgttcagcc accacgggca tttgtattca gcatttaaag
    11881 accacctttt gcctaccgga atctctactt ccagatttgg cgccaacgcc aaatcgtaca
    11941 acagattatt cttcactgca agcaccgttt tactttcaac cggcccttct gcctccgaca
    12001 ctaccacctc atcctcataa gccatactct ctttactttc tccctccggc ttatcaggtt
    12061 gatcgctcgg aagcgcctct tcctgctttg aaacaaacaa tccgaagaca gaagataccg
    12121 gttcaaaagt attcttttcc atttccggaa cctcccggac aaccgtaatc tcagcgcgtc
    12181 tcaactcagg taacacattg cggacaatgt atcggtaagc cattccctga ttcaacttct
    12241 gcaacagttc ttttcgcttc acagtgttat cccgatgata atctatcaac atcaagactt
    12301 cttcccggtc cggcaagtct gaatccgacg ccaccaactt acgaagttca gaccaatctt
    12361 ctccttccga agtaagttta atcttttcga catcaacata cggataacgt tgccttaaga
    12421 actctctcat cgaattgttt cttcggacag ataatgcggc attgtaaacc gaatctccgt
    12481 caggcgatac aaaagtgacc acattgagcg cagtgatata tcttgaattt attttttctt
    12541 caagcaaaga atctaaaaca ttaatttcat gattattagt tttataacta aaatcaatat
    12601 ctgtttcttc cttatcgaaa tatatcacca cccgcctgat agtgtcactc gcaaccgtga
    12661 gaaccggaat cgctgcatac acactttctg ataaagcaag aaatgccatg agaataacgc
    12721 atgtatagat cccgtttttc ataattgttc gtttctgtga acaaatatag aagttaataa
    12781 ctaaataaaa tcatactacc ggaacaaaaa aacaggcttg gaaggttctg tgaaacgatt
    12841 ggaaggaatt tgcaagtttt aagagtatgg atggatagaa caagcgtaaa aaagcgaaac
    12901 tccagaagtt gaaaagctat ttttccacga tactacacag aagttataaa tgaaaaacat
    12961 ctgccatctg caacaaaatc gaaataacta tttaatcaac atttgattac agcgttgcag
    13021 atacctgttg cagataagtg acagatacca ccatctgcaa caccggtata aacagggaag
    13081 gcgccgctta tatcggaaat ggaagataac ctcctattat cggagaaatg atttccgaag
    13141 cagaaacgac agtatccagg aaggaaacga tagttcccaa ggcgggaaac gatagttccc
    13201 aaggcaagat actgcagttc ccaaggcggg acactgcagt atccaaggca ggaaactgat
    13261 ggcttactta tatgattcaa ttaacttgac cgtaacaact gttcgattaa cctgctcttc
    13321 caagaaacaa taaatcattt atcagtcaaa aacaactgag ttatcaacca ttaaaggctg
    13381 atttctcatt tattaatgtc tgatatacca atcattaata gttgacactt cagttattaa
    13441 catcctgtaa atcaaaagat aatatcaaac aaatgacaaa caatgatata tggaagagtg
    13501 agagcaaacg cttgctctca tacctgccac cacacttgct accatacctg aaactacgat
    13561 gaataaagga atacagacct ttcattagag catgagagca aaactactat caaatcactg
    13621 tgtggcatgt tgaattcaag ttatcaatgc gatccgacag attccagatt ttaatttgag
    13681 ttttattgtt gttattacga ctacaaagtt acataaaaaa gcctttgtta agtcctcaag
    13741 cccttcgagc gttaattaca aattaaataa ttggaacact ggcatataaa caaaggttgc
    13801 atcgtcaatg actaacaagt ttgttactaa caactttgtt agtaacaaac ttgttagttt
    13861 attaaagaat cgctatattt gcaaggttcc aacaaaaaga taagcatgga aaagccattt
    13921 gtttttggtg tagccacttc cggagataac ttcaccgatc gagagaaaga aacccagcgt
    13981 ctgctcctta atttcacaca tggtgtgaac acaatactta tatccccaag aagatggggg
    14041 aaaacatcgc ttgtgaagaa agtagcccag ctagctcaaa caaagaccag aaagatagtc
    14101 tatttagaca ttttctcctg tcgtaccgaa agcgaattct atcgtctttt tgctacttct
    14161 gtattaaaac aaacttcttc caaatgggac gagtgggttg agaacaccaa acaatttctc
    14221 gcacatatca atcccaaaat ttccattggc acagacccta tgaacgactt ttctatctct
    14281 tttgagtata gcatgcagga taatgccgga aatgatatct tgcaattacc tgaaaagatt
    14341 gcgatagaaa aagggattca aatagtgatc tgcattgacg agttccaaca aatctcagat
    14401 tttgaggatt caaaaacatt tcagaaaaag ctacgtacgg tgtggcaact acagcagcat
    14461 gtctcatatt gcctttttgg aagtaagaaa catctgatga atgaactttt cgaaaaaaag
    14521 aatcttccat tctacaaatt cggagatgcg atctatctca ccaaaataga gactaaatat
    14581 tggatagaat atatctgcaa acgctttgaa aataccggga agcacatttc acccgagctt
    14641 gccaaagaaa tctgtcgcct tgtggacaat cactcttcct acgtacaaca acttgcctgg
    14701 ttgctttgga tacgcaccac cgatatagca acagaggaac agctgactca tgctctggaa
    14761 gatttactag accaaaacaa tattcttttt caaagcgaaa ctgaaaatct ctccgcttat
    14821 cagatgaatt tcctaaaagc ggtcatcgat gggatacact ctaaatttag cagtaaggag
    14881 atcattctaa aatataacct cggaacctct gccaatatcg ttcggctgaa gagtgcatta
//
