LOCUS       gnlProkkaCOCFLFDA_146  10813 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|COCFLFDA_146.
ACCESSION   gnlProkkaCOCFLFDA_146
VERSION     gnlProkkaCOCFLFDA_146
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 10:33:45
            Original ID  :: gnl|Prokka|COCFLFDA_146
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10813
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..273
                     /locus_tag="ctg146_1"
                     /transl_table=11
                     /translation="MMKGKDVDYYLNQAGGYSDNARKSKKFIVYMNGQVTKVKGSGKKQ
                     IEPGCEIIVPGKAKKKGNIANILGYATSFSSLGMMIASIANLIKK"
     protocluster    1..10813
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[1499:5813]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1500..5813
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..10813
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10813
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             288..1436
                     /locus_tag="ctg146_2"
                     /transl_table=11
                     /translation="MSEQRQDKNLLSEPHKTESDEIEIDLVDIFRKIIAIRKKLYKAVG
                     IGFIIGIIVAVSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVLFGKSLLASLRKELKNKEIEQDK"
     CDS             1500..2219
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 56.8; E-value:
                     3.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg146_3"
                     /sec_met_domain="NTP_transf_3 (E-value: 4.2e-17, bitscore:
                     52.9, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CGIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLIAPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             2240..3541
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 209;
                     E-value: 1.4e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg146_4"
                     /sec_met_domain="CTP_transf_like (E-value: 2.3e-13,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 9.7e-122, bitscore:
                     395.5, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.2e-63, bitscore:
                     204.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKTILENERALEVRELCMPIKEILELIPGTK"
     CDS             3558..4682
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg146_5"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.3e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.1e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             4692..5813
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg146_6_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg146_6"
                     /sec_met_domain="Aminotran_5 (E-value: 1.8e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        4782..5789
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg146_6_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg146_6_Aminotran_5.1"
                     /locus_tag="ctg146_6"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             5810..6283
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156:Chloramphenicol acetyltransferase (Score: 73.7;
                     E-value: 2.7e-22)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg146_7"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYSNIY
                     LGKNAEIRSGCYLIARDKIIIGENSTLAYGTTILTTADPNGPYNALAVLYPYKKAPVVI
                     GDNVWIGANVTILPGVTIGDYVVVAAGAVVTKDVPSGVLVAGVPAIVKKRFNK"
     CDS             6280..7725
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg146_8"
                     /sec_met_domain="Polysacc_synt (E-value: 9.6e-33, bitscore:
                     103.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEKTSLKNKAICGIFWSAVERFLSQGIQFVVTVIMARFLLPSDY
                     GMVGMLAIVLQLSQTLMDSGFTNALIRYKERTEIDYSTVFFFNILASLVIYFLIFFLAP
                     YISWFYKIGQLVEITRILSIVIVLNSFAIIPKTKLIIAVDFKTQSKVSFIAALVSGIIG
                     IWAAYLDFGVWALVGQTLVNGLLIVVLYAYFCRWKPLWIFSLKSFRLLFAFGSKLVLAN
                     ILNTLYKNLYAIVIGKKFSSVDLGFYTRAEQFAQFPSYNLSAIISRVTYPILSLVQNDN
                     DRLSALYRKYVRLSSAFIFPLMILLIVIAQPLVLLLLTEKWIGVVVLLQILCLDWMFDH
                     LSSINLNLLYVKGRSDLALRLEVIKKVLATGILLLSIPWGIVGMCWGRVMYSLIAVYLN
                     TYYTESLIKLSLIRQMRDILPSFFLALIMGGGTWYMILLLEGEIVQIVVGSVIALLLYG
                     TLLYCFSRSLFDEIWAVILKIKR"
     CDS             7725..8447
                     /locus_tag="ctg146_9"
                     /transl_table=11
                     /translation="MDKLSLIISKIRRNHWYRTYMRPIYLFVYGNRKLKNRNRIFLQYS
                     QELLTNFHQAMNEVGIPYWLEFGTLLGAVREHSFISHDFDLDVGLFKEDYSDIIREVLK
                     KYGFKRIRCITALDFIDAYEETYLYKGVTIDLFLFSREKNCDGVYCYDFVPVYSDIKRT
                     KKGDNAIRRIHFPRIDLIEYSFIGINTFVPENYEEHLCMHYGKDYMIPNPHWKDSDAQH
                     TDIFYGREIRIELFDKSK"
     CDS             8461..9474
                     /locus_tag="ctg146_10"
                     /transl_table=11
                     /translation="MFYLFFLLIVLFLLYIQSRKRQYSTVAGICVPIIIIFVVICRYRV
                     GYDYLTYYTLIENEEEAQILYLFSPLSIVWAEIALYFESPQMLFVLFGLPTFALLIFTL
                     KKYSKDYALSVTILICFFFFTSLSIIRQALALAICFYGYRFIVKRSLIKYILCILIAAL
                     FHPSAGVAIIIYWLPFLKFRLVVLLSIISIVAKPLFFYMLNILGVYTSYLDGKMDIEGG
                     KYTQLIYFLLFIICFVLGSKNIDKNKCNLFNVLLLSFVFVSFLGAHLGGRIAFYFNIYY
                     CLLIPKVVKGLDGQLREQVKLLSYFLCISYFLLYLFVPFIKGVPSYYIPYKFIFFK"
     CDS             9479..10438
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123:polyprenol-monophosphomannose synthase ppm1
                     (Score: 57.2; E-value: 3.2e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg146_11"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.2e-42,
                     bitscore: 135.7, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLISIIVPCYNSERYLSDCLLSILNQTYVNWEVICIDDGSQDNTL
                     SILNHYATLDERFKIISQSNAGVSVARNKALSQCQGEYICFVDSDDLIEPNFLITLLQL
                     ISHQADLAICGFTRSMVFCMDDAQGYIEMSGKRCIERIILDKSFNPQICCMLFRHNIIK
                     EKQLEFVIGCTRGEDREFILKYLVYSNKVCYTNNLLYHYRVNDQSAMAIFSIKSLTSIE
                     ASQRTVNYYKKVNYSVRGLEFEFSRTLWKFMILAILSGQNDLYQIIREKYDLKRQMEHL
                     YSHPGLSEKLTARLFVWNEALFKWVFSIIRYLYKKRWR"
ORIGIN
        1 tatatgaagg gaaaggatgt ggattattac ctgaatcagg ccggtggcta ttctgataat
       61 gcaaggaaga gtaagaagtt cattgtttac atgaatggtc aggtgacgaa ggttaagggt
      121 agtggtaaga aacagattga gccggggtgt gagattattg tgcctggtaa ggctaagaag
      181 aaagggaaca tagctaatat tttaggttat gctacttcct tcagttcttt gggtatgatg
      241 attgcttcta ttgctaatct tataaagaaa taatagaatt tacttttatg tcagaacaac
      301 gacaggataa aaacttgctc tctgaaccac acaagacaga aagtgatgag atagaaattg
      361 atttggtcga tatctttcgc aagattattg ctattcgtaa aaaattatac aaagccgttg
      421 gaattggttt tattattgga ataattgtag cggtaagtat ccctaaacag tatacagtaa
      481 aggttaccct ttctcctgaa atgggtaatg cgaaggggag taatggttta gccggacttg
      541 ctgcctcgtt tttaggagat ggggctctaa taggggaaag cacagatgcc ttgaacgctt
      601 ctctttcagc agatattgtt tcttcaactc cttttttatt ggaactttta gaaatggaag
      661 tctccgtttc taaaaaggat gataaaatga ctttggggtc ttatctcgat gaagagtcat
      721 ctccttggtg ggattatctt ataggttttc cgggcatagt aataggagga gttaaatcat
      781 tattcggaga agatacggtt cctgccagtg gagggcggca aggaactatc gaattgacga
      841 aagaagtaaa tgagaagatt aattttctta aaaagaagat tagtgcatcc attgataaga
      901 aaaccgccat aacgagcatt acggtcacct tacaaaatcc gcagatcact gcggttatag
      961 cagattctgt cgttcataaa ttacaggaat atattattgg gtatcgaact tcaaaagtaa
     1021 aagaagactg tgcgtatttg gaacggttgt ttaaagaacg tcagcaggaa tattatgctg
     1081 ctcaaagaaa atatgcggat tatgtagacg cccatgataa tgtggttctt caaagtgtac
     1141 gtgctgagca ggagcgttta cagaacgaca tgagtttggc ttatcagata tatagtcagg
     1201 ttgctaatca gttgcaggta tccagagcca aagtacagga ggaaaagcca gtctttgcag
     1261 tagttgagcc tgccgttgta cctttgaaac cttcaggtat gggactcaaa atttatattt
     1321 tattatttgt gttcctgtcc gtatctggta ctctcgtgtg ggtgcttttt ggcaaaagtc
     1381 tgctggctag cttgagaaaa gaactgaaaa ataaggagat agaacaggat aaatgatgct
     1441 aaaacgtcgt ttacaacatt cttatatcaa ttaaattcac ttactatatt attaaacgaa
     1501 tgatacgtac agctatgata atggctgcgg gcatgggaac ccgttttggc caatatacag
     1561 aattgatacc taaagggttc gtcaaagtgg gaggtattcc aatgatagtt cgttctattg
     1621 atactttgtt atcatgtggc attgagcgaa ttgtaatcgg tacaggatat aaacaagaag
     1681 tttatgaaga attgaagaca gactatccta tgcttgaaac ctgttttagt cctcgttatg
     1741 ctgaaacaaa tagtatgtat actttatata atacgcggga gattctgggc aatgatgatt
     1801 ttttattgtt agagtcagat ttgatttttg agaaacaagc aataatgagc ttattggagt
     1861 gtcctgcggc agatgcaatg ctaatagctc cagtgacaaa gtttcaagat cagtattatg
     1921 tggaacatga tgataatttt cgcctttctt catgttctgt caataagaat aaactaaacg
     1981 ctaaaggcga attggtcggc atccataaac tatccggttc cttttacaaa ataatgtgtg
     2041 ctgattatgc gagtattgtt gatgaacaac ccaatttggg atatgagtat gaattactac
     2101 gaatatcttg ttctcaatct cctgtttatg tgcataaagt agaagggctg aaatggtatg
     2161 aaatcgatga catatcagat ttggaatatg cagagaaata tattgttccg tattgttaat
     2221 taaaataata tatcaaatta tgagtaagac agtttatatt gggatgactg cggatattat
     2281 gcatccagga cttatccgca ttattaatga ggctactaaa tacggtgatg ttataattgg
     2341 tcttcttaca gataaagcta ttgcggagca taaacgcctt ccttatctga cctatgaaca
     2401 acgaaaagag gtagttcaga atattaaagg cgtatgtaaa gttgttcctc aagaagaatg
     2461 gagctatgtt gagaatctca aacgcattaa acctgactat ataattcatg gtgacgactg
     2521 gaaaaccggg cctttacgtg aagaacgtgt gcgcgtattt gaagtgatga atgaacaggg
     2581 aggaaaggtt atcgaaattc catatacttt gggaattaat tcatcttctt tggataaaga
     2641 tattaaggct ataggtacaa cccccgatgt acgtttaaaa tcacttcgtc gtttgataaa
     2701 tgccaaaccc gtagttcgta ttttggaagc tcatgatgga ctatgtggct tgataattga
     2761 aaatcaggaa atattaaaag gggataagag ggaagtattt gacggaatgt ggtctagtag
     2821 ccttacggat tcaaccagta aaggtaaacc tgatattgag gcggttgatt taactacccg
     2881 attgcaagat ttgaataata ttctggagtg tactactaaa cctattattt ttgatggaga
     2941 tacaggtggt aaaattgaac atttcgtatt tacagtacgc actttagaac gtcatggaat
     3001 ctcagctata ataattgaag ataaagttgg attaaaaaag aattcattgt ttggtacgga
     3061 tgttattcaa actcaagata caatcgaagg tttctgtaat aagatcaaag caggaaaggc
     3121 atctcagatt actgatgatt ttatgattat cgctcgtatt gagagcctta tagcgggaaa
     3181 gccggtaagt gatgctttag agagagcttt tgcatatgtc caagcgggag cggacggtat
     3241 tatgatacat agcaaaaata agtcgggtga agatataaaa gaattttgtt tggcgtttcg
     3301 aaaacagtat gctcatgtac ctatcgtggt tgtgcctact acatatgatc atatttatga
     3361 gtctgaattg tgtgattggg gtgtgaatat aattatttat gctaatcata tgcttcgtgc
     3421 cgcttatcct gctatgatga atgtcgcaaa gacaatatta gagaatgaac gtgctttaga
     3481 ggtgcgcgaa ctgtgtatgc ccataaagga aatattggaa ctgattccgg gtactaaata
     3541 aaaagaggaa tatcattatg ttaagcgtag aaaaagttta tgaaacgttt ctgagtcatg
     3601 acgttgattt ttttacagga gttccagact cattactaaa aaatatttgt gcctatatca
     3661 cagaccatac ttcacgtgag aaacatatca tagctgctaa tgaaggtgcg gctgtaggaa
     3721 ttgcttcagg ttattatatg gcatcaggta aggttcctgt ggtttatatg caaaattccg
     3781 gcttgggtaa tactgttaat cctctgctgt ctcttgcaga tgaacaagta tacagttttc
     3841 caatgctttt gatgattggc tggcgtggtg aaccgggaac aaaagatgaa cctcagcata
     3901 aaaaacaggg tgaggtaact ttagatttgt tgaaagcaat gcggattcct tatataattc
     3961 ttgattcaaa tgagaatgat gcatttattc agctccatga tatcatacaa tcagcaaaaa
     4021 ctaagaatat tcctcatgca ataattattc ggaaagatgt ttttggcaaa tataaacttc
     4081 aaaaagagtt cggatgtaat tatcctttat ctcgtgagga tgctttgcaa atagttgtgg
     4141 attatctgcc tgaaaattca gtggtcgttt ctactactgg caagctttct cgtgagttat
     4201 ttgaatatcg agaaatgaaa gagcaaggtc atgaacatga ttttctcacg gtaggctcta
     4261 tgggacatag ttcatcaatc tctttgggta ttgctatagc aaagcaagat agacctgttt
     4321 attgcttgga tggtgatgga gcatttatta tgcatttagg ggcaattagt aacattggcg
     4381 atttatctcc taaaaactat tatcatattt tgtttaacaa tggtgctcac gagtctgtag
     4441 gaggacagcc tactttagga tttagtttag atattccggc tattgtccgg gggagcggat
     4501 ataagcatac ttatactgtt tgtacaaaag ttgaaattga agaagcaatg aagcagcttc
     4561 caaagttatg tggtcctgtt ttgttggaaa taaaggttaa aatagattct cgggagaatt
     4621 tgggacgtcc cacgactact cctatagaga ataaggagca ttttatggat tttttaaaat
     4681 aaatatattc gatgaaaata gaaagaaaaa tattattaaa tcctgggcct gccactacta
     4741 ctgacagtgt aaaaatggca caagttgttc cggatatttg tcctcgcgag aaagaattcg
     4801 caggtatgat gaaacaactt cgggacgatt tggtcagagt tgctcatggg aatttggaaa
     4861 aacataccgc tgtattattt tgtggctcag gaaccatcaa tattgatata tgtctaaatt
     4921 ctcttcttcc tgaagacaaa agggtgctta tagtgaataa tggggcatat agtacccgtg
     4981 ctgtagaagt gtgtcaatat tatggtttgc ctcatattaa tttggaattt tccgtttacg
     5041 aacgtcctga tttatcggtg gtggaaaatg tgttgcaaga aaatcctgat atagctatgg
     5101 tttatactac tcatcacgag acgggtacag gaattctgaa ccctattcgc gagatgggcg
     5161 ctatagctca taaatatcag gctaaatttg tcgtcgatac tacttcttct ttgggcatga
     5221 ttccttttga tatagagaaa gataatgtgg atttttgtat ggcatctgct caaaaaggac
     5281 ttcaagcgat gacaggtctt tcttttatta taggcaatga ggaacagatt aagttttcaa
     5341 aaaaatatcc caagcgttct tactattgta atctttattt gcagtatgag aattttgaga
     5401 gaacaggtga aatgcatttt actccaccgg tacaaactat ttacgccact cgtcaggcat
     5461 taaatgaata ttttgaagtg ggcgaagaag ctaagtttgc ccgtcacaaa agagtttttg
     5521 aggctattca ttcaggtata aatgaaattg gtcttaaaag tgtaataaag cgtgaatggc
     5581 agtcaggact ggttgtctca gttcaatacc cagaagatcc caactgggat tttgagaaaa
     5641 tacatgatta ttgttatgag cgtggattta cgatttatcc aggtaagata tcaactgagg
     5701 atacttttag aatctgtgct ttaggagaga tagaagtaga tgatattgag aacttcttta
     5761 aagtactaaa agctgcatta aatcattata acgtcacatt accgatgtca tgattgcaga
     5821 aatattattg aagattcgtc atttttattt ttcccttcgt ggtatacact tccatccgga
     5881 aagtgttatt tctggagtgc ctattcgtag ctttcgctta gtaggcaaat atagcaatat
     5941 ctacttaggt aaaaatgctg aaatacgttc aggctgttat ctgattgctc gtgataaaat
     6001 cattattgga gaaaactcaa cactcgccta tggaacgact atattgacaa ctgctgatcc
     6061 taatggaccg tataatgcat tagcagttct ttatccttat aaaaaggcac cggtagttat
     6121 aggagataat gtttggattg gggctaatgt taccatcctt cctggagtaa ctattggtga
     6181 ttacgttgta gtagcagctg gagctgttgt aacaaaagat gtaccttcag gagtattggt
     6241 agctggtgta ccagctattg tgaaaaaacg ttttaataaa tgaaagaaaa aacttcttta
     6301 aagaacaaag ccatatgtgg aatcttttgg agtgcagttg aacgattttt atcacagggg
     6361 atacagtttg tagttacagt cattatggcg cgttttctat tgccatctga ttatggaatg
     6421 gtaggaatgt tagcaatagt tcttcaatta tctcaaacgt taatggatag tggttttact
     6481 aatgccctta ttcgttataa ggaacgtact gaaattgatt attcaacagt tttctttttt
     6541 aatatattag catcattagt tatttatttt ctaatttttt ttctagctcc ttatatatcg
     6601 tggttttata aaataggtca attagttgag attactagaa ttttatctat tgttattgtt
     6661 ttaaattcct ttgcgattat tcctaaaact aaattaataa tagctgtaga ttttaaaact
     6721 caatcaaaag tctcatttat tgcagctttg gtttcaggta ttattggcat ttgggctgca
     6781 tatttagatt ttggagtttg ggctttagtt ggacaaactt tagtaaacgg attgttgatt
     6841 gtagttttgt atgcatattt ttgtagatgg aaaccattgt ggatattttc attgaaatcg
     6901 tttcgtttat tatttgcttt tgggtcaaaa ttagtattag ctaatattct taatacttta
     6961 tataaaaatc tgtatgctat agttatagga aagaagtttt cgtcggttga tttaggattt
     7021 tatactcgtg cggaacaatt tgctcagttt ccttcatata atttgagtgc aataatttct
     7081 agagtgacat accccatatt gagccttgtg caaaatgata atgatagatt atctgcttta
     7141 tataggaaat atgtccgttt atcttctgct tttatctttc cattgatgat tttgttaatt
     7201 gtcatagctc agccactggt attattgctt ttgacagaaa aatggatagg agtagttgta
     7261 ttgcttcaaa tattgtgttt agattggatg tttgatcatt tgagtagtat aaatttgaat
     7321 ttactatatg taaagggacg ttcagacttg gctttacgtt tagaagttat aaaaaaagtg
     7381 ttagcgacgg ggatccttct tctatctatt ccttggggga ttgtaggtat gtgttggggg
     7441 cgtgttatgt attcattgat tgctgtgtat ttgaatactt attatacaga atcattgatt
     7501 aaattaagtc ttattagaca gatgagagat atactaccaa gctttttttt agcattaata
     7561 atgggaggag gtacttggta tatgatttta ttgttagagg gtgaaattgt tcaaattgta
     7621 gtaggaagtg ttattgcttt attgctatat ggaacgttgt tgtattgctt ttctcgatcc
     7681 ttgtttgatg aaatatgggc ggttatatta aaaataaaaa ggtaatggat aaactgagtt
     7741 tgattattag taaaatacga cggaatcatt ggtatagaac ctatatgcgt cctatatatt
     7801 tatttgttta tggcaataga aaattgaaga atagaaatag aatatttttg cagtattcac
     7861 aagagctgct aactaacttt catcaagcaa tgaatgaagt gggaattcct tattggttag
     7921 aatttggaac tcttttaggt gctgttagag aacacagttt tataagtcat gattttgatc
     7981 ttgatgtggg cctttttaag gaagattatt cagatataat aagagaggtc ttaaaaaaat
     8041 atggtttcaa aagaataagg tgtataaccg cccttgattt tattgatgct tatgaggaaa
     8101 cttatcttta taaaggtgtg acaattgatc ttttcctttt ttcaagagag aaaaattgtg
     8161 atggggtcta ttgttatgat tttgttccag tatattcaga tataaagaga actaaaaaag
     8221 gtgataatgc aatccggaga attcattttc ctagaattga tttgattgaa tattcattta
     8281 ttggaattaa tacttttgtt cctgaaaatt atgaggaaca tctttgtatg cattatggta
     8341 aagactatat gattccaaat cctcattgga aagattcaga tgcgcaacat actgatatct
     8401 tttatggtag agagattaga attgaattgt ttgataaaag taaataatag tagataatac
     8461 atgttctatc tatttttttt actaattgtg ctatttttgt tatatataca aagtaggaaa
     8521 agacaatatt ctactgtagc gggaatttgt gttcctatta ttataatttt tgttgtaatt
     8581 tgtcgttata gagtggggta tgactattta acgtattata cattaattga aaatgaagaa
     8641 gaggcacaga ttttatactt attttctcct ttaagcattg tttgggcaga gattgcttta
     8701 tattttgaat ctccacagat gttatttgtt ctttttgggc ttccaacatt tgctcttcta
     8761 atatttactt taaaaaaata ttcaaaagat tatgcgttat cagtaactat tttaatttgt
     8821 ttcttctttt ttacatcact cagtattatt cgacaagctt tggctttggc tatttgtttt
     8881 tatggttatc gttttatagt aaaacgttca ctaattaaat atatattatg tatattgatt
     8941 gcagctttat tccatccttc tgcaggagta gcgattatta tatattggtt gccatttcta
     9001 aagtttagat tagttgtatt attatctata atatcaatag tagccaaacc tttatttttt
     9061 tatatgctaa atatattagg ggtgtatacc tcttatcttg atggcaagat ggatattgaa
     9121 ggtgggaaat atactcaatt aatatacttt ttgttgttta ttatttgttt tgttttggga
     9181 agtaaaaaca tagataaaaa caagtgtaat ttatttaatg ttttattgtt aagttttgtt
     9241 ttcgtatctt ttttaggagc tcatttaggc gggagaatag cgttttattt taatatatat
     9301 tattgtttgt tgattcctaa agtggttaaa ggattggatg ggcaactaag agagcaagtg
     9361 aagcttcttt cttattttct atgtatttct tatttcttat tgtacctatt cgttccattc
     9421 ataaaaggtg taccctcata ttatatccca tataagttta tatttttcaa atagtaaaat
     9481 gttgatatct ataattgtcc cttgttataa ttctgaaaga tatttgtctg attgtttatt
     9541 gtctatattg aatcaaacct atgttaattg ggaggtgatt tgtatagatg atggaagtca
     9601 agataataca ttatctattt taaatcatta cgctacattg gatgagcgtt ttaaaattat
     9661 ttctcagtct aatgcaggag tgtctgtcgc aagaaataag gctctatccc agtgtcaagg
     9721 agagtatatt tgctttgttg atagtgatga cctgatagaa cctaattttt tgataacact
     9781 tttacagctt ataagtcatc aggctgattt ggcaatctgt ggttttactc gttctatggt
     9841 tttctgtatg gatgatgctc aaggatatat agaaatgagt ggtaaacgtt gtatagaaag
     9901 aattattcta gataaaagtt tcaatcctca gatttgttgt atgttatttc gacataatat
     9961 tataaaagag aaacaattag aatttgtgat agggtgtact cgtggtgaag atcgtgaatt
    10021 tatattgaaa tatttagttt attctaataa ggtttgttat acaaacaatc ttctttatca
    10081 ctatcgtgta aatgatcagt cagccatggc aatcttttct attaaaagtt tgacaagtat
    10141 agaagcttca caacgcacgg tcaactacta taaaaaagtg aattattctg ttagagggct
    10201 tgaatttgaa ttttcacgta cattgtggaa attcatgatt ttagctattt tgtctgggca
    10261 aaatgattta tatcaaatca ttcgagaaaa gtatgatcta aaaagacaaa tggaacatct
    10321 ttattctcat ccaggactat ccgaaaaact tacagcgaga ttgtttgttt ggaatgaggc
    10381 actttttaaa tgggtatttt ctattattag atatctatat aaaaaaagat ggagatgaat
    10441 aaacgaaata gattatctga acaagaaata aaaaaagtag aacttgacgc tttattgtat
    10501 attcggaaaa tttgtcagca atatcatctt cgctattatt tagcttgggg tactttgttg
    10561 ggagccgtta ggcataaagg atttattcct tgggatgatg atattgatat aatgatgcca
    10621 cgttcagatt atgagcgatt attggagtta gttccttcct tgagacatag ttattataaa
    10681 atcttaagta atccaaagaa tgaggattat tattatactc atgcaaaaat gatagatact
    10741 cgtactttgt gtgtggaaaa tgatttgcaa actattcaaa atatggggat ttgggttgat
    10801 attttcccct tag
//
