LOCUS       c00083_gnlPro..        14253 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|COCFLFDA_83.
ACCESSION   c00083_gnlPro..
VERSION     c00083_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 18:09:29
            Original ID  :: gnl|Prokka|COCFLFDA_83
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14253
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14253
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[224:4253](+)"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      225..4253
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..14253
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14253
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             225..4253
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg83_1"
                     /sec_met_domain="HGD-D (E-value: 3.2e-28, bitscore: 91.1,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 5.9e-35, bitscore:
                     112.7, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGISEKCSLPFVQEVVAAAKAIQKDYSHVTSMIDIGGEDAKVVFF
                     KDAEATDLRMNGNCAGGTGAFIDQMAIILGVNIDELNQLAMNATQVYPIASRCGVFCKT
                     DIQNLIAKNVSRENIAASIFRAVAVQTVVTLAHGCDITTPVLFCGGPLTFIPALRKAFI
                     DYLSLDEKEIILPANGTLLPALGAALFHLDKEDYCKLSHLIDKIDTTLNGNGNLASTGL
                     EPVFASNEEYEAWKERISRHKMISSGLKAGTQDVFIGIDSGSTTTKIVVLDEDSRLLYS
                     YYNINGGNPIKAVEEGLNQLNDECLKQNAVLNIKGSCSTGYGEDLIRSAFQLHSGIIET
                     IAHYMAAHYLNKDVSFILDIGGQDMKVIFVNNGVIDRMEINEACSSGCGSFLETFAKSL
                     GYSAQEFSLAACHSEAPCDLGTRCTVFMNSKVKQVLREGATINDIAAGLAYSVVKNCLY
                     KVLKLKDISVLGKDIVVQGGTMRNDAVVRAIELLSGAEVARCDTPELMGAFGCALYAMK
                     HQGESVSLDEIINKAQYSARSLYCKSCDNRCLVIRYEFESGKSYYSGNRCEKVFTNGES
                     SNRKGLNVYRQKEELLFHRSAEIAAPEQIIGIPRCLNMYEEYPFWHTLFTSCGIQVCLS
                     DPSNFRKYEHNARMVMSDNICFPAKLVHSHVQDLIEKKVDRIFMPFVIFERKGMEQNSY
                     NCPIVTGYSEVIKSVQSEGISVDSPAITFKDRNLLFKQCREYLSGLSVDDRTIQQAFQK
                     AESEQHSFINTLVDYNKNILQQTGKGETLTVMLAGRPYHTDSLIQHKVSDMLSDMGVNV
                     ITDDLVRQMDIPTGDAHFVAQWAYTNRILKAAKWCATQGKNIQFVEMTSFGCGPDAFLV
                     DEVRDLLMRHNKSLTLLKLDDINNIGSMKLRVRSMIESLKLANADGTEGDVKDFTTVPV
                     YDKSYRDRKILVPYFTPFISPLIPAIMKVAGYDAENLPLSDNDSSEWGLKYANNEVCYP
                     ATLIVGDIIKALKSGKYDISKIAVAITQTGGQCRASNYISLIKKALVDAGYTDIPVISI
                     SVGSDIDNDQPAFKVNWMKVVPITFHAVLYSDCIAKFYYASVVREKEAGASAKLRDKYL
                     QLAPEVILRRNIKGLNSLLQSAITEFNEVCRAVDTPKVGIVGEIFLKFNPFAQKEIIDW
                     LIGRKIEVVPPILADFFMQGFVNRKVNTDSYIKNRQLPEFIYDWIYKFVKKQIDKINET
                     ASKFRYFAPFNDIFEEAEGAKSVISLNAQFGEGWLLPAEIVSYARQGVNNVVSLQPFGC
                     IANHIVSRGVEKRIKSFYPDINLLSLDFDSGVSDVNITNRMLLFIDNLKNATMNYDNN"
     CDS             4240..4863
                     /locus_tag="ctg83_2"
                     /transl_table=11
                     /translation="MTTTNNNEDLEKKIIEAAKELFIENGFAETSMSDIAAKVGINRPA
                     LHYYFRTKDKMFQAVFGNIILSFIPKIHDIIIQQDKPVSESIGEIVDAYYKVFTENPCL
                     PLFMVREMHRDMNHLSDTIKELRLEQYLHKIMDVLQEEMNDGRLKTVPLPFVFYTFYSA
                     LTVPFLTKNLSASFFLEKDDSFEDILVQWKPYIVRQMETLLVVS"
     CDS             complement(4871..5542)
                     /locus_tag="ctg83_3"
                     /transl_table=11
                     /translation="MGMKDVFKRYLVFVIGLYFLAAGIVLIVRSALGTTPISSINYVLS
                     LNSPLSLGTCTFLINMLLILGQFWVIRKNRTRQDTIEILLQLPFSFIFSAFIDFNMALT
                     SNLHPDNYGMSIALLLTGCMIQSIGVVLELKPKVAMMSAEAFVKYASRRYNKEFGKFKV
                     CFDVTLVTLAVILSLLLSQCIEGVREGSLIAACITGYIVSFLNQKIMTRKTLYKLLPVL
                     K"
     CDS             5699..6589
                     /locus_tag="ctg83_4"
                     /transl_table=11
                     /translation="MVKSRIFDNRQLLKEHPEIPHYKEEVVCFMSEYKDRSYPENERYF
                     NRELYMILVLEGRSEILLNGEFIVIEPDMLLVHGANYLTDHLYSSPDIKFITLSISESM
                     RTDDSYLTQITAILLATMRQNKQYTIQLTAYEAQIIRNELEVLMRLLNIKHQFLFRRIQ
                     AACNALFLDIADFLSRKTIIKKEVSRKDHVLQEFHALVTRNFREEHFVSFYADKLAISE
                     QYLARIVRAGTGKSVNTIINELLIMEARTLLSSTKSTVGDIASRLGFSDAAGFCKFFKR
                     NMGQTPLNYRKGLWI"
     CDS             complement(6676..8433)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Transketolase_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Transket_pyr"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Transketolase_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg83_5"
                     /sec_met_domain="Transketolase_C (E-value: 1.8e-16,
                     bitscore: 52.0, seeds: 80, tool: rule-based-clusters)"
                     /sec_met_domain="Transket_pyr (E-value: 9.4e-18, bitscore:
                     56.2, seeds: 81, tool: rule-based-clusters)"
                     /sec_met_domain="Transketolase_N (E-value: 5.5e-07,
                     bitscore: 20.5, seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYLENIYSPADVKKLSFQELNDLSHEIRASLLQKLSAHGGHFGPN
                     FGMVEATIALHYVFNSPKDKIVYDVSHQSYVHKMLTGRKDAFLHPAEYDHVSGYSEPQE
                     SEHDFFVIGHTSTSVSLASGLAKGRDLTGGNENIIAVIGDGSLSGGEAFEGLDYVAELG
                     TNMIIIVNDNQMSIAENHGGLYKNLKDLRDSNGQCECNFFKAMGLDYMYVNDGNCVEAL
                     IEAFSKVKDIQHPIVVHINTLKGKGYEPAEQDKETYHWRTPFDLETGKSKMNDDAEDYS
                     EVTAQYLLKKMKEDKRVVTITSGTPAVLGFTPDRRQEAGKQFVDVGIAEEHAVALASGI
                     AANGGKPVYGVYSTFIQRSYDQLSQDLCINNNPAVLLVFWGTLSGMNDVTHLCFFDIPL
                     ISNIPNMVYLAPTCKEEYLAMLEWSIHQNEHPVAIRVPATDVISCGEPVESDYSNLNRY
                     KVAHRGSKVAILALGSFFGLGQSVLSLLKEKANIDATLINPRYITGVDSELMDELKADH
                     ELVITLEDGVLDGGFGEKIARYYGATDMKVLNYGAKKEFVDRYDIQELLRANHLTDEQI
                     VEDILSLIG"
     CDS             8856..9551
                     /locus_tag="ctg83_6"
                     /transl_table=11
                     /translation="MDRKGFLKSTMIATGSLLLGGAGICRFLNDKEPADGPFPRTIEKI
                     HCGNMKKVLVIMSAGTKLGNTDRLTDAYIKGLVERGHSVTKVYLGSMRIEGCRGCGVCQ
                     RLAHQCAVRDGMQDIYPLFAECDTVVMASPLYFWTITSQLKAFIDRLYAISADDKYPQK
                     DTVLLMTAGDDNENTFDQPKQYFRLLSQALGWNEVGIYCAGGCTGCEKLARQIDKVHLE
                     NVYKMGLEL"
     CDS             9566..10771
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1058:Major
                     facilitator family (Score: 103.7; E-value: 3.3e-32)"
                     /gene_kind="transport"
                     /locus_tag="ctg83_7"
                     /sec_met_domain="MFS_1 (E-value: 2.8e-32, bitscore: 103.7,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQKNQSKLHSGGLLVFILTVGVFGIINTEMGVVGILPLIAETFD
                     VSVPQAGWTVSIFALVVAASAPVTPLLFSGVNRKKVMLLALGLFTLSNIISMLTTNFTV
                     LLVARILPAFLHPVYVSMAFTVAAASVSKEKAPKAVSRVFVGVSAGMVLGVPVTSFIAS
                     EVSFSMSMLFFTVVNALVLIATILFIPSMPVKEKVSYGAQLSVLKRTVMWNSIIAVTLI
                     NGAMFGFFSYMSDYLKTVTEVSYSVISVVLLVYGLANIVGNVLAGKLLSINARRSIIIM
                     PFALLVSYICLFITGEWITAMVIIILILGVLAGIASNNMQYMIAEAAPEAPDFANGMFL
                     TSANLGTTIGTAVCGAFITEMGTRYSVFGALFFLIASIVFVYLRVRVAHSQKQVKMNMA
                     TE"
     CDS             10902..11933
                     /locus_tag="ctg83_8"
                     /transl_table=11
                     /translation="MKRILLLTVVFIMMLGTSFSFAQADADNFYKSDWVKVEKVSFSNQ
                     YKMKVAGNLFLPKTMKEGEKYPAIIVGHPMGAVKEQSANLYATKMAERGFVTLSIDLSF
                     WGGSEGEPRNAVLPEVYAEDFSAAVDFLGTRPFIDRNNIGVIGICGSGSFAISAAKIDP
                     RLKAIATISMYNMGTASRNGLKHALTLEQRKQIMAEAAEQRYAEFLGGETKYTGGTVHE
                     ITENSGPIEREFYEFYRTQRGEFTPEGATLTTTTHPTLSSNVKFMNFYPFEDIETISPR
                     PMLFITGENAHSREFSEDAYRLAADPKELYIVPGAGHVDLYDRVGLIPFDKLESFFKEY
                     LKK"
     CDS             11983..12846
                     /locus_tag="ctg83_9"
                     /transl_table=11
                     /translation="MKQIKNTHYEGERPLFASHGLYLEEVTIHAGESALKECSDIEAVN
                     CRFEGKYPFWHNDGFVVKNCLFTEGARAALWYSRNLKMKDTLVEAPKMFREMDGVELEN
                     VQLPNALETLWYCRNVELNNVKIDKGDYLFIHGEDIRIKNFVLNGNYSFQYCKNVEIRH
                     AEIHSKDAFWNTENVTVYDSVLDGEYLGWHSKNLRLVNCKISGTQPLCYAHDLIMENCT
                     MADDADLAFEHSSVKATIKGPVHSVKNPRTGNIVAESFGTIILDENLKAPGNCELKLWD
                     GLTCFD"
     CDS             12852..14009
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg83_10"
                     /sec_met_domain="Aminotran_1_2 (E-value: 5.6e-48, bitscore:
                     155.6, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYNFDEIVPRRGTNSYKWDSAGDADVLPMWVADMDFRTAPSVVE
                     ALKRRVEHGIFGYVRVPDAYYEAITRWFAGRHGWQIEKEWIIYTTGVVPALSAVIKALT
                     TPGDKVIVQTPVYNCFFSSIRNNGCEVVANPLIYMNGTYQIDFIDLERKAADPSVKVLL
                     LCNPHNPAGRVWTKQELTRLGEICLRNNIWVVADEIHCELVFPGHTYIPFASVSEEFLM
                     HSVTCTSPSKAFNLAGLQIANIVSADTDIRMQIDKAININEVCDVNPFGVEALIAAYND
                     GEEWLEELNQYLFANYHYLRAYFDEYLPEFPVLPLEGTYLVWVDCSALKQSSEDIVKTL
                     LEKEKLWVNEGNLYGEAGERFIRINIACPRQRLIEGLNRLRRALK"
ORIGIN
        1 agtttttcag attttatttg tacctttgcc atgtcttgtt acgatttacg cttgttttga
       61 tttgcaacac taagataagt gaaaaatctg acatggcaaa atcctgagca actttttgtt
      121 gctcaggaac ttataaataa agttaaatca aagtgttgcg gaattaaggg ttatctgaaa
      181 tcggagataa agatatttcc gtgaggataa caggctctat cggaatggga atttcagaga
      241 aatgttcgtt gccgtttgta caggaggttg ttgcggcagc gaaagcgata caaaaggatt
      301 attctcatgt gacttctatg atagacatcg gaggagaaga tgcgaaagtc gtcttcttta
      361 aggatgccga agcgaccgat ttgcgtatga acggcaattg cgcaggaggg acgggcgctt
      421 ttattgacca gatggcgatt atactgggag tgaatattga tgaattgaat caacttgcca
      481 tgaatgcgac acaggtatat cctattgcct cccgttgtgg cgttttctgt aaaacggata
      541 ttcagaatct gatagctaaa aatgtaagtc gtgagaatat tgcggcttcc atctttcgtg
      601 cggtagcagt tcaaacggta gtgacgctgg cgcacggttg cgatattaca actcccgtat
      661 tgttttgcgg tggtccgtta accttcattc cggcactgcg gaaagccttc attgattatt
      721 tgtccctcga tgaaaaagag atcatactgc cggccaacgg cactttgctc cctgcactag
      781 gtgctgctct atttcatctt gataaagagg attactgtaa actgtcccat ttgatcgata
      841 agattgacac tactttaaac ggtaacggta accttgcctc aacaggattg gaacctgttt
      901 ttgcaagtaa tgaagaatat gaagcatgga aagaaagaat atcccgtcat aagatgatat
      961 cttccggctt gaaagccgga acacaggatg tctttatcgg catcgattca ggttctacta
     1021 cgacaaagat tgttgtactg gatgaagatt caaggcttct gtattcttat tataatatta
     1081 atggcggcaa tccgataaaa gctgtggaag aggggctgaa tcagttgaac gatgaatgtt
     1141 tgaagcagaa tgccgtactc aatataaaag gaagctgttc taccggatat ggggaagacc
     1201 ttatcaggtc tgcctttcag cttcattcgg ggattatcga aacgatcgcc cattatatgg
     1261 cagcgcatta tctgaacaag gatgtgtctt ttatcctcga tatcggcgga caggatatga
     1321 aggttatttt tgtgaataat ggcgtgattg accggatgga gattaatgaa gcatgctctt
     1381 ccggatgtgg ttcttttctt gaaacgtttg ctaaatctct ggggtattcg gcacaagagt
     1441 tttctctggc agcctgccat tcggaagcac cgtgtgattt gggaacaagg tgcaccgttt
     1501 ttatgaactc aaaagtgaaa caggtactca gggagggggc aacgatcaat gatattgccg
     1561 ccggactggc atattccgtt gtcaagaatt gcctgtataa ggtgttgaaa ctgaaagata
     1621 tatctgtttt gggaaaagat attgttgtgc agggaggcac catgcgcaat gatgcggtgg
     1681 tccgtgccat tgaacttctc tcgggagcgg aagtggcaag gtgtgataca cccgaattga
     1741 tgggagcatt cggatgtgca ttatatgcga tgaaacatca gggggagtcc gtatcattgg
     1801 atgagattat caataaagct caatattcgg cacgttcttt atattgcaag agttgcgata
     1861 atcgttgtct ggtcattcgt tacgagttcg aaagcggcaa aagttattat tcgggaaaca
     1921 ggtgcgagaa agttttcacg aatggagaga gcagtaaccg gaaaggtctg aatgtctatc
     1981 ggcaaaaaga agagcttttg tttcatcgca gcgcagagat tgcagcaccc gagcagatta
     2041 tcggaatccc ccgatgtctg aatatgtacg aggaatatcc attctggcac actcttttca
     2101 cttcctgtgg catacaagtc tgtttgtctg atccgtccaa tttcagaaag tatgagcaca
     2161 atgcgcgtat ggtgatgtcg gacaatatct gctttccggc taagctggta catagtcatg
     2221 ttcaggactt gatagaaaag aaggtcgacc ggatttttat gccttttgtt attttcgaaa
     2281 gaaaagggat ggaacaaaac agttataatt gtccgattgt gacaggttat tcggaggtta
     2341 tcaaaagtgt gcagtccgaa ggtatatcgg ttgattcccc tgcaataact ttcaaagacc
     2401 ggaatctgtt gtttaaacaa tgccgtgaat atctgagcgg tttgagcgtg gacgatcgga
     2461 cgattcagca agcattccaa aaagcggaaa gcgaacagca ctcttttatt aatacattgg
     2521 tcgattataa caaaaacata ttgcagcaga ctggaaaggg agagactctg actgtcatgc
     2581 ttgccggacg tccttatcat accgattctc tgatacagca caaagtctcg gatatgcttt
     2641 cggatatggg agtgaatgtg ataacggatg atttggtgcg tcagatggat ataccgacgg
     2701 gtgatgcgca ttttgttgct caatgggcgt atacgaaccg tatcctgaag gctgcgaaat
     2761 ggtgtgcgac acaaggaaag aatattcagt ttgtagagat gacttcgttc ggatgtggac
     2821 cggatgcttt tctggtggat gaagtaaggg atttgctgat gcgtcataac aaatcgctga
     2881 ctttattgaa actggatgat atcaataata tcggttcaat gaagttgaga gtacgttcca
     2941 tgattgaaag cctcaaactt gcgaatgcgg atggaacgga aggcgatgta aaggacttta
     3001 cgaccgttcc tgtctatgac aagtcttacc gtgaccgtaa gatactggtt ccttacttta
     3061 ctccgttcat ttcacctttg attcctgcta ttatgaaagt agccggttat gatgcggaaa
     3121 accttcctct cagtgataat gattcaagtg aatgggggct gaagtatgcg aataatgagg
     3181 tctgttatcc ggctactctg atagtcggcg atattataaa agcacttaaa agcgggaaat
     3241 atgatatttc aaaaatagcc gtagccatca cccaaacggg aggacaatgc cgtgccagca
     3301 actatatttc cttgataaaa aaggcgttgg tggatgccgg atatacggat attccggtaa
     3361 tctctatctc tgtgggcagt gacatagata atgaccagcc cgcgttcaag gtcaactgga
     3421 tgaaagtagt accgataact tttcatgccg ttttgtatag tgattgcatt gctaagtttt
     3481 attatgcgtc tgtggtacgt gagaaagaag caggtgcatc ggcaaagctg cgtgataaat
     3541 acctgcaact ggcacctgaa gtgatactga gaagaaacat aaaggggttg aactctttgt
     3601 tgcaatcggc aatcactgaa tttaatgagg tgtgtagggc tgtagatact cctaaagtcg
     3661 gaattgtagg agaaatcttc ttgaaattca atcctttcgc acaaaaagag atcattgatt
     3721 ggctgatagg ccgcaagata gaagtggttc cgccgattct ggctgacttt ttcatgcagg
     3781 ggtttgtgaa caggaaagtc aatacggatt cttacataaa aaacagacag ttgcctgagt
     3841 ttatttacga ctggatctac aagtttgtaa agaaacagat tgataaaata aatgagacag
     3901 caagtaagtt ccgttacttt gcccccttca atgatatctt tgaagaagcg gaaggagcta
     3961 aaagcgttat ttcgctgaat gcccaattcg gtgaaggctg gttgttgccg gctgaaatcg
     4021 tgtcttacgc ccggcaaggg gtgaacaatg tagtgagttt gcaacctttt ggctgcatag
     4081 cgaatcatat cgtatccaga ggagtcgaaa aacgtataaa aagtttctat ccggatataa
     4141 atttgctatc tttagacttt gatagtggtg tgagcgacgt aaacataaca aaccgtatgc
     4201 ttttgtttat tgataatctg aaaaatgcga caatgaatta tgacaacaac taataataat
     4261 gaagatttgg agaaaaagat aattgaggct gccaaagaac tatttataga gaatgggttc
     4321 gcagaaacca gtatgagtga tatcgctgct aaagtaggta tcaacagacc ggcacttcac
     4381 tattatttcc ggacgaagga taagatgttt caggccgttt ttggtaacat catactttct
     4441 tttattccca aaatacatga tataatcatt cagcaggaca aacctgtctc cgagagtatc
     4501 ggtgaaattg tagatgctta ttataaagta ttcacggaaa atccatgttt gccattgttc
     4561 atggtgaggg agatgcatcg tgatatgaat catttaagcg atactatcaa ggagttgcgc
     4621 ctggaacaat atctccataa aatcatggat gttttacagg aagaaatgaa tgacgggaga
     4681 ctgaaaacag ttcctttgcc attcgtattc tatacttttt atagtgcatt gacagttcct
     4741 ttcctgacaa agaatctcag tgcttctttc tttttggaga aggatgattc ttttgaggat
     4801 attctggttc agtggaaacc ttatatcgtc aggcagatgg aaacgttgct ggtagtgagc
     4861 tagagaaaac ttatttcaat acaggtaata atttgtagag agtcttcctt gtcattattt
     4921 tctgattcag gaagctgacg atatatccgg tgatgcaggc ggcgataaga gacccctcgc
     4981 gaacaccttc gatgcattgt gaaagcagga gagagagtat gactgccaga gtgaccagcg
     5041 taacatcaaa acagactttg aactttccaa actctttgtt ataacggcgg gaggcgtatt
     5101 ttacaaaagc ctctgcgctc atcattgcta ctttgggttt gagttcgagt acgactccta
     5161 tggattgtat catgcatcct gtgagtaata aggctattga catcccgtaa ttgtcgggat
     5221 gcagattact ggtgagcgcc atattaaaat caatgaatgc cgaaaagata aaagagaacg
     5281 gcaattgaag gagtatttca atggtgtcct gtcgggtcct attttttctg atgacccaga
     5341 actgtcccag gataagcagc atattgatca gaaacgtaca agttcctaat gataaagggc
     5401 tgttcaggct taacacataa ttgatgctgg atataggtgt ggttcctaat gcagaacgca
     5461 caatcaacac tattccggca gccagaaaat acaatccgat aacaaatacc aaataccttt
     5521 taaaaacgtc tttcattccc atatcttact atcttatata atcgtatttt tcttcattct
     5581 ataaagaaga atatgcaaag gtcccgtttt ttcgtctgat ataagttatc cgattccaca
     5641 cagtttttgt catatccgaa acaaattgta tttttacgtc gaaaagaagg aggtataaat
     5701 ggtaaaatct cgtatttttg ataataggca gttgttaaag gaacatccgg aaattcctca
     5761 ttataaagag gaagtagtct gctttatgag tgaatataag gacaggagct atccggaaaa
     5821 cgaacgttac tttaatcgtg aactttatat gatactcgtt cttgaaggtc gttccgagat
     5881 tttgctgaat ggggaattta ttgtgataga gcctgatatg ttgcttgttc atggagcgaa
     5941 ttatctcacc gatcatcttt attcgagtcc ggatattaag tttatcaccc tctccatttc
     6001 cgagtccatg cggacagatg actcttatct tacccagata acggctattc tgttggcaac
     6061 gatgaggcag aataagcaat ataccataca gctgaccgca tacgaagctc aaatcattcg
     6121 taatgaactg gaagtgttga tgcgtttgct gaatataaaa catcagtttc ttttccggcg
     6181 aatacaggcg gcttgcaatg ccttgttttt ggatatagcc gattttcttt cccgtaagac
     6241 tatcataaaa aaggaggtca gtcgtaaaga ccatgtttta caggaatttc atgcgcttgt
     6301 tacccgaaat ttcagagaag agcatttcgt tagtttctat gcggataagt tggccatcag
     6361 tgagcagtac cttgcacgta tcgttcgtgc cggaacggga aaaagtgtga atacgattat
     6421 taatgagtta ctgatcatgg aagcccgtac cttgctgagt tccacaaaat ctacggtagg
     6481 ggatattgct tcccggcttg gctttagtga tgctgccggt ttctgtaagt ttttcaagag
     6541 gaatatgggg cagactcctc tcaattatcg gaagggatta tggatttaag tgaaaatgaa
     6601 tgtaggttga tgtgatccca taacgaacgg atacatcaac ctacatgaaa tatataatga
     6661 actggttttg acttatcagc caatgagtga taggatatct tctacgatct gttcatccgt
     6721 cagatggttg gcacgaagca gttcctgtat atcataacgg tctacaaatt cttttttagc
     6781 tccgtagttg agcactttca tatctgtagc gccatagtaa cgggcaatct tttcaccgaa
     6841 accaccatcc agaactccgt cttccagtgt aatcactaat tcgtggtcgg ctttcagttc
     6901 gtccatcagt tcgctgtcca cacctgtgat gtagcgggga ttgataaggg tggcatcaat
     6961 gttggctttt tctttcagca gtgacagaac cgattgccct aatccgaaga aggagcctaa
     7021 tgcaaggatt gctactttgg agccacggtg ggcgacttta taacgattga gattgctata
     7081 gtcggattcc accggttcac cgcaactgat tacatctgtg gcaggtacac ggatagctac
     7141 cggatgctca ttttggtgga tgctccattc cagcatggcg agatattcct ccttacaggt
     7201 aggtgccaga tagaccatat tggggatatt gctgataagt ggaatatcga agaaacagag
     7261 gtgagttaca tcattcatac cggataacgt cccccagaat accaacagaa ctgccggatt
     7321 attattgatg cagaggtctt gcgatagctg gtcgtaagaa cgttgtataa aggtgctgta
     7381 cactccgtaa accggttttc cgccattggc tgcgataccg gaagcaagtg ccactgcatg
     7441 ctcttcggca ataccgacat ctacaaactg cttgcctgct tcctgacgac ggtcgggagt
     7501 gaagcccaaa acagcggggg tgcccgaagt aatggtaact acacgcttgt cttctttcat
     7561 ctttttcagc agatattgag cggttacttc actataatct tctgcgtcgt cgttcatttt
     7621 tgattttccg gtttctagat caaacggagt acgccagtga taggtctcct tgtcctgttc
     7681 tgcaggttcg taacctttgc cttttaatgt attgatgtgg actactatcg gatgctgtat
     7741 atctttaact ttggagaaag cctcgatcag tgcttccaca cagttgccgt cattcacgta
     7801 catatagtcc agccccatcg ctttgaagaa attgcattca cattgaccgt tactgtcgcg
     7861 caaatctttc agatttttgt ataagcctcc gtgattttcg gcgatggaca tctgattgtc
     7921 attgacaata ataatcatgt tagtaccgag ctctgctacg tagtccagtc cctcgaaggc
     7981 ttcgcctccg cttagtgaac cgtcgcctat tacagcgatg atattttcgt tgccgcctgt
     8041 caggtcacgt ccttttgcca gtccgcttgc caagctgaca gaagtagaag tatgaccgat
     8101 cacaaagaaa tcatgttcac tttcctgtgg ttctgagtag ccggatacat gatcatattc
     8161 agcaggatgg agaaaagcat ctttgcgtcc ggttagcatc ttatgtacat aactctgatg
     8221 tgacacatca tatacaattt tatctttcgg cgaattgaaa acatagtgca gggcaatggt
     8281 tgcttctacc attccgaagt tagggccgaa gtgcccaccg tgtgcactca gtttttgtaa
     8341 gagtgatgca cggatttcat gacttaaatc attcagttcc tgaaacgata acttctttac
     8401 gtctgcggga gagtaaatat tttctaaata catatcaatt tgttttttta tgtttatacc
     8461 tatattttta tttcactgca aagatactga cggatttgaa atctgtttgt atatgaatta
     8521 cggattcttt tacctatatt acagttccgc taaaaatggg cttgataaaa cataaaatac
     8581 gacttcctct atatcaacca tatgctcttt tgcaagcttg attcttttta cctgaatata
     8641 ctgttgtaat aggtatcgcg cacgcgtaat cattatataa tagcaaaata ggatgctata
     8701 ataatatctg ttcttgtgtg atagaaagat ggaaacctat aatctgtaat tggggtaatt
     8761 atacccgtaa tctgtctaca atcccttcac ttaattcttc cgacctttgt actgtcgaat
     8821 caccttgagt atatggaact aattatataa agaatatgga tagaaaaggc ttcttgaaaa
     8881 gtacgatgat agcaaccgga agtttactgt taggcggggc ggggatttgt cggtttctga
     8941 atgataaaga acccgcagat ggtccgtttc cccggacaat agaaaaaata cattgtggaa
     9001 atatgaaaaa ggtacttgtt ataatgagcg cggggacaaa actcggtaat acagaccggt
     9061 tgaccgacgc ttatattaaa ggactcgtgg aacggggaca ttcggtaacc aaagtatatc
     9121 tgggcagtat gcggatagaa ggctgcagag gttgcggcgt atgccagcgg ctcgctcatc
     9181 aatgtgcagt tcgggatggt atgcaggata tatatccttt gtttgcagaa tgtgacacag
     9241 tggtcatggc ttcacctttg tatttctgga caatcacgtc acagttaaaa gcttttatag
     9301 acaggcttta cgccatctct gccgacgaca agtatccgca gaaagatacg gtattactga
     9361 tgacagccgg tgacgataat gagaacacct ttgaccaacc caagcagtat ttccggcttc
     9421 tgagccaggc attgggttgg aatgaagtcg gaatatattg tgccggcggt tgtaccggat
     9481 gcgaaaagct ggcacggcaa atagataagg tacatcttga aaatgtctat aaaatgggat
     9541 tggaattgta aatagcagat ttaatatgga acaaaagaat caatcaaaac ttcattcggg
     9601 cggtttgctc gtatttatcc tcacggtcgg tgtgtttggt attataaata ccgaaatggg
     9661 ggtagtgggt atcctgcctc taatagccga aacttttgat gtctcggtgc cgcaggcagg
     9721 ttggacggtg agtatctttg cactggtggt agctgcatcg gctcctgtca ctccgttatt
     9781 gttttcggga gtaaaccgga agaaagtcat gttgctggca ttgggattgt ttacactgag
     9841 taatattata tccatgctca ctaccaattt tacagtacta ttggttgcgc ggatacttcc
     9901 cgcctttctt catccggtat atgtttcgat ggcttttaca gtagcggcgg catcagtcag
     9961 caaggaaaag gctccaaagg ctgtttcaag ggtttttgtc ggtgtgtctg ccggtatggt
    10021 gctgggtgtt ccggtgacca gctttatagc tagtgaggtc tcattctcta tgtcaatgct
    10081 gtttttcaca gttgtaaatg ccttggttct tatagctacg attttgttta tcccctccat
    10141 gccggtaaag gagaaagtat cttatggtgc acaactcagc gtattgaaga gaacggtgat
    10201 gtggaactct atcattgccg tcaccttgat taatggagct atgttcggct tctttagtta
    10261 tatgtcggac tatctgaaaa cagtgacgga agtatcatac agtgtgatta gtgttgtatt
    10321 attggtctat ggtctggcta atattgtagg taacgtactt gccggaaaac tattatcgat
    10381 aaatgcgcgg cgttcaatta ttatcatgcc ttttgcattg ctggtttcct atatatgtct
    10441 ctttataaca ggagagtgga ttacagctat ggtaatcatt attttaattt taggtgtatt
    10501 ggcaggtata gcaagtaata atatgcaata tatgatcgcg gaagctgctc ccgaagctcc
    10561 cgactttgcc aacggaatgt ttctgacttc tgccaatttg gggacaacga tcggtacagc
    10621 cgtatgcgga gctttcatca cggaaatggg cacacgctat tctgtattcg gtgcattgtt
    10681 tttcctgatt gccagtattg tgtttgttta tttgagagtt cgtgtagctc attcacagaa
    10741 acaagttaaa atgaatatgg caacggaatg atgaaaaata tataatccgt aattggggta
    10801 ataatgtcag taattcatct acaaacactc tctttatttc accgtatttt tgtaatgtag
    10861 aaagtagaca atcaattcat taataattaa atgtaagaga tatgaaacga atattattat
    10921 taaccgttgt atttattatg atgcttggaa ccagtttttc tttcgcacag gctgatgcgg
    10981 ataactttta taaaagtgat tgggtaaagg tagaaaaggt ttctttttct aaccagtata
    11041 aaatgaaagt agccggcaac ctgtttttgc cgaagaccat gaaagaggga gagaaatatc
    11101 ctgccatcat tgtcggacac ccgatgggag cggtcaagga acagagtgcg aatctgtatg
    11161 ctactaaaat ggcggaacgt ggtttcgtta cgctgtccat tgatttatcc ttctggggtg
    11221 gaagtgaagg tgagccgcgc aatgctgttt tgccggaggt atatgcggag gatttcagtg
    11281 ccgcagtaga ttttttgggt acacgtccgt tcatcgaccg aaataatata ggtgtaatcg
    11341 gaatttgtgg cagcggaagt ttcgctatca gtgcggccaa gatagaccct cgtctgaaag
    11401 cgattgcaac catcagcatg tacaacatgg gtacagccag ccgcaacgga ctgaaacatg
    11461 cgctgactct ggaacaacgg aaacaaatca tggctgaggc agcagaacag cgctatgcgg
    11521 aatttctggg cggagaaact aaatatactg gcggcactgt acatgaaata acagaaaact
    11581 ctggtccgat agaacgcgaa ttttatgagt tctaccgcac tcagagggga gagtttactc
    11641 ccgaaggagc aaccctgaca actaccacac accctacact ttcaagcaac gtgaaattca
    11701 tgaatttcta tcctttcgaa gatattgaga ctatttcgcc ccgtcctatg ctttttataa
    11761 ccggagaaaa tgcccactca cgcgaattta gtgaagatgc ctaccgactg gctgccgacc
    11821 ccaaagaact gtacattgta cccggtgcag gtcatgtaga cctttacgac cgtgtggggc
    11881 ttataccatt tgataaattg gaatcctttt ttaaggaata tctgaagaaa taagtatgaa
    11941 caggaaaaac agataactat ttaaataaaa gacaatcgaa tcatgaaaca aattaaaaat
    12001 acacattacg aaggcgaacg tcctttgttc gcatcccacg ggctttattt ggaagaagta
    12061 accattcatg ccggtgaatc ggcactgaaa gagtgcagtg atatagaagc ggtaaactgt
    12121 cgtttcgagg gaaaatatcc gttttggcat aatgacggtt ttgtagttaa aaattgcctt
    12181 tttaccgaag gagcacgtgc cgcactctgg tattccagaa atctgaagat gaaggataca
    12241 ttagtggaag caccgaagat gtttcgcgaa atggacggag tcgaactcga aaatgtacag
    12301 ttgcccaatg ctttggaaac actctggtat tgccggaatg tagaactgaa caatgtgaag
    12361 atagataaag gagactatct ctttatacat ggggaagaca tccgcatcaa gaattttgta
    12421 ttgaatggca attactcctt ccaatattgc aagaacgtag aaatccgcca tgctgaaatc
    12481 cattcgaagg atgcattttg gaatacggag aatgtgactg tatatgattc tgtattggac
    12541 ggtgaatatt tgggctggca ttctaaaaac ttacgtttag tgaattgtaa gatctcgggc
    12601 acgcagccac tttgttatgc acacgacctg ataatggaaa actgcacaat ggcggatgat
    12661 gccgatcttg ctttcgaaca cagtagtgtg aaggcaacga ttaaaggccc ggttcacagc
    12721 gtgaagaatc cccgtacggg aaacattgtt gccgaaagtt tcgggacaat catcctggac
    12781 gagaacctca aagctccggg aaactgcgaa ttgaaacttt gggacggact gacttgtttt
    12841 gattgaaata tatgaagtac aacttcgatg aaattgttcc acgcagaggt acaaattcct
    12901 ataaatggga ttctgccgga gatgcggatg tattaccaat gtgggtagct gatatggatt
    12961 tccgtacagc tccctctgtg gtggaagcac tgaaaaggcg ggtggaacat ggtatcttcg
    13021 gatatgtgcg tgtgcccgat gcttactatg aggcgataac aagatggttt gccggacgtc
    13081 atggctggca gattgaaaaa gaatggatta tttatacgac cggagtagta ccggccctgt
    13141 cagctgtcat caaggcgctg acaactcccg gtgataaagt aatcgtgcag acacctgtct
    13201 ataactgctt tttctcctcc atccgcaata acggatgcga ggttgttgca aatccattga
    13261 tttacatgaa cggaacgtat cagatagact ttatcgattt ggaacggaag gcggctgacc
    13321 cgagtgtaaa agtcctgcta ttatgcaatc cgcacaatcc tgccggaaga gtctggacaa
    13381 agcaggaact gactcgcttg ggagaaatct gtcttcggaa taatatatgg gtagtagcgg
    13441 acgagattca ttgcgaactt gtctttccgg gacacaccta tatccctttt gcatctgtct
    13501 cagaagagtt tttgatgcat tccgttactt gcacctcgcc tagtaaagcc tttaatttgg
    13561 cggggcttca gattgccaat attgtttctg ctgatacgga tatacgaatg caaatagaca
    13621 aggcaatcaa tatcaatgaa gtctgtgatg taaatccgtt tggcgttgaa gccttgatag
    13681 ctgcttacaa tgacggggaa gaatggctgg aagaacttaa ccaatacctg tttgccaact
    13741 accattattt aagggcttac tttgatgaat atcttcccga atttccggtg ctgccattgg
    13801 aaggtaccta cttagtatgg gtagattgct cggctttgaa acaatcgtcg gaggatatag
    13861 tgaaaactct gttggagaag gaaaagcttt gggtaaacga aggcaatctg tatggagagg
    13921 ctggcgaaag gtttatccgt attaacatcg cgtgtccgcg acagcggttg atagaaggat
    13981 taaacagatt gaggcgggca ttgaaataat aaaataattg tcagtttatt aataggttcc
    14041 ccttctcact ccccgtaaat acaaataaaa agaagtgata tgaaaagtca gaatccctca
    14101 aagaggaatt tgccgggtgt tatcatcgct tatttcctca tttatgtagt ctggggctcc
    14161 acctattttt ttataggggt ggctttgaaa gatttttcac cttttctgct cggagcactg
    14221 cggtttacga ctgcagggct gatacttctt gga
//
