LOCUS       gnlProkkaJIDIIJKE_46   13412 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JIDIIJKE_46.
ACCESSION   gnlProkkaJIDIIJKE_46
VERSION     gnlProkkaJIDIIJKE_46
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 15:14:53
            Original ID  :: gnl|Prokka|JIDIIJKE_46
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13412
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13412
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3064:3412]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3065..3412
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..13412
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13412
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             2..145
                     /locus_tag="ctg46_1"
                     /transl_table=11
                     /translation="MDTVTTLILSRLASFLPFFEVIPEILCKFVRRKLKEYRNENISKQ
                     QH"
     CDS             117..1628
                     /locus_tag="ctg46_2"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIEHEPIASIDLMERAAQALTKAITNRWNP
                     ETPVTIFAGPGNNGGDALAIARMMAEKGYKIEVYLFNTKGELSPDCQTNKELVEMMEEV
                     TFHEISTQFVPPTLTPEHLVIDGLFGSGLNKPLSGGFAAVVKYINASPAMVVSIDIPSG
                     LMGEENTFNVKSNIIRADVTFSLQLPKLAFLFAENTEFVGEWELLDIQLSEEGIEETET
                     NYEMLEIEEIRSLIKPRQQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPLCNNDILQTSAPEAMVEADVSETCFAVPTDTDDYQAVGIGPGLGRNEETEAALIEQ
                     LEHCQTPTVLDADALNILANHRHTLTHLPKGSILTPHPKELERLVGKCQDSYERLMKAC
                     ELAHTAKVHIILKGAYSAIITPEGKCYFNQTGNPGMATGGSGDVLTGVILALLAQGYPA
                     EDAAKIGTYIHGLAGDIAQKKQGMIGLIASDIVTCLPTAWRLVSE"
     CDS             1702..2766
                     /locus_tag="ctg46_3"
                     /transl_table=11
                     /translation="MKKLIIATGLLMATSAYAQTEVLTGVTRGKDYGVVYALPKTQIEI
                     EIKANKVNYKPGEFSKYADRYLRLTNVSAEPEEYWELNSVKVKPVGVPNSEATYFVKLK
                     DKTVAPLMELTEEGLIKSINVPYSSNNAKNAANNAVAPQRKANPRDFLTEEILMASSTA
                     KMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNLQEEAMTEMFSGVRNK
                     EEKTFTVRLTPDKEFDNEVAFRFSKKLGIVANNDLAGTPFYISLKDLKTVKIPQEDGKK
                     KKEMEGIAYNVPGQAMVTLTDGKKKLYEGEIPVTQFGIIEYLAPVLFNKNSTIKVYFDP
                     VTGGLLKVDREESK"
     CDS             2788..3075
                     /locus_tag="ctg46_4"
                     /transl_table=11
                     /translation="MGGEGHMLDMIRRLKDGKEASRLRRERRNDKLGRLRRNNDPYLLP
                     DTTPEEMERIIKDSEKKKEKDNSYFVWGTLIIMGVLIGCAVLLWAIFFNG"
     CDS             complement(3065..3412)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg46_5"
                     /sec_met_domain="PF05402 (E-value: 2.3e-17, bitscore: 53.8,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PqqD_RRE (E-value: 8.6e-10, bitscore:
                     29.0, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATKEKINLLEVIPCRNEHIKAEQEGETIVLSFPRFKRSWMSRYL
                     LPKGMSKDIHVRLEEHGTAVWNLIDGQRTVREIIEKLADHFQYEAGYESRVSTYLSQLQ
                     KDGFIKWIIIH"
     CDS             complement(3457..4845)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 91.3; E-value: 8.1e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg46_6"
                     /transl_table=11
                     /translation="MTEQLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AITTTFPEGAMLFGFKMQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDESGVFHTNIPAPILFCLVMLCVGTIAFFIYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMVIGSVMLIFVHTMFAL
                     PILNIWWFATVIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNSYCKGPVVDGAQTYDYTLPMAIFAMFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             complement(5538..6332)
                     /locus_tag="ctg46_7"
                     /transl_table=11
                     /translation="MTSVNLQQWIQHPETLNRDTLYELRNQLARYPYFQSLRLLYLKNL
                     YILHDINFGAELRKAVLYIADRRKLFHLIEGERFAVESQKKGLPLSEVLKDEPTVDRTL
                     ALIDAFLSTAPEEVTSQTSFDYSMDYTAYLLEETPVVDEPAEAMPKLKGHELIDNFIEK
                     SETDPVVYLKPLKEEEKAKAASSAETNETGRTDETTETNTVEEEDDSCFTETLAKIYVK
                     QQRYSKALEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             complement(6337..6864)
                     /locus_tag="ctg46_8"
                     /transl_table=11
                     /translation="MNWIKKIARPLILVVLPAVIIACSVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPNQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSSQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             complement(6851..8092)
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 388.8; E-value:
                     6.1e-118)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg46_9"
                     /transl_table=11
                     /translation="MTKAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPLPTQARLLRVLESGEFIKVGSSKVQKTDVRIVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFAADFAEKYRMPAIQLTEDAKKI
                     LLAYPWPGNVRQLKNITEQISIIETNREITAAILQTYLPAQNTQRLPALFGTRESKSFE
                     SEREILYSVLFDMRQEVAELKKMVHNMMAERAGQVGQMGQVVATPVVTTTHQPSVPAII
                     HAVQQPSVCPKEDDDDIQDTEEYVEETLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             complement(8216..9310)
                     /locus_tag="ctg46_10"
                     /transl_table=11
                     /translation="MEENKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPK
                     VAAYHRKALDVQANFSIVNTASEAGYNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     RAIEEYREGLIDVIVTAPINKHTIQSEEFSFPGHTEYIEERLGDGNKSLMILMKNDFRV
                     ALVTTHIPVREIATTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLG
                     MEEQEIIIPAMKEMEEKGIICYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAM
                     EDGVNYTAGLPVVRTSPAHGTAYDIAGKGLASEDSFRQAIYVAIDVFRNRQREKAARVN
                     PLRKQYYEKRDDSDKLKLDTVDED"
     CDS             complement(9315..10352)
                     /locus_tag="ctg46_11"
                     /transl_table=11
                     /translation="MKKYFFYLSMALVAFVVASCGLKGNHTSSGRPYELLVVVDAGVWD
                     RAAGRALHDVLDSDMPGLPQSEPSFRIMYTSPKDYDSTLKLIRNIVIVDIKDIYTKGTF
                     KYAKDVYASPQMILTIQAPNEEVFEKFVEENKQTIIDFFTRAEMNRQITLLEEKHNNFI
                     SNKVDSLFGCDIWIPSELNNSKTGEDFFWASTNTGSADRNFVMYSYPYTDKDTFTKEYF
                     VHKRDSVMKANIPGYKEGVYMSTDSLLTDVRPINVHNDYTMEARGLWRMKGDFMGGPFV
                     SHTRLDQKNQRIITAEIFVYSPDKMKRNLVRQMEASLYTLKLPQEGQQSQIPLGVTKEA
                     EPTNK"
     CDS             complement(10370..11404)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg46_12"
                     /sec_met_domain="PF04055 (E-value: 1.9e-17, bitscore: 54.8,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKYPLLGMTLIELQSLVKRLGMPGFAAKQIASWLYDKKVTSIDE
                     MTNLSLKYRELLKQNYEVGAEAPVEEMRSVDGTVKYLYPVGENHFVESVYIPDDERATL
                     CISSQVGCKMNCKFCMTGKQGYSANLTAHQIINQIHSLPERDKLTNVVMMGMGEPLDNL
                     EEVLKALDILTGSYGYAWSPKRITVSTVGLRKGLRRFIEESDCHLAISLHSPVTAQRAE
                     LMPAEKAFSITEMVELLKNYDFSKQRRLSFEYIVFKGLNDSQVYAKELLKLLRGLDCRI
                     NLIRFHSIPGVALEGADMDTMTRFRDYLTTHGLFTTIRASRGEDIFAACGMLSTAKQEE
                     NNKS"
ORIGIN
        1 atttgacacc gtaacaactc tgatattaag tcgtttagcg tcatttctcc cgtttttcga
       61 ggttattcca gagattttgt gtaagtttgt gcgtcgaaaa ctaaaagaat atcgcaatga
      121 aaatatttcc aagcagcagc attaagaagt tagatgccta taccattgaa catgaaccga
      181 ttgcatccat agatttaatg gagcgtgccg cacaggcgct gactaaagcc atcaccaaca
      241 gatggaatcc ggaaacacct gtcaccatct ttgccggacc gggcaataat ggcggagacg
      301 ccctcgccat cgcccgcatg atggcggaaa aaggatacaa gatcgaagta tatctcttca
      361 acacgaaagg cgaactttcg cccgactgcc agaccaacaa agaactggta gagatgatgg
      421 aagaagtaac tttccatgaa atcagcaccc agttcgtacc tcccacactg acaccggaac
      481 atctcgtgat cgacggatta ttcggttccg gactcaacaa accattgagc ggaggattcg
      541 ctgccgttgt gaaatatatc aatgcctctc ccgccatggt agtctccatc gacatccctt
      601 ccggactgat gggagaagaa aatacattca atgtaaaaag caatattatc cgtgcggacg
      661 tcactttcag cctgcaactt cctaaactgg ccttcctctt tgccgaaaat acagaatttg
      721 ttggcgaatg ggagttattg gacatccagc tgagcgaaga aggaatcgaa gagactgaaa
      781 caaactacga aatgctggaa atcgaagaaa tccgttcact gatcaaacca cgccaacaat
      841 tcgcccataa aggaaacttc ggacatgccc tgctgatagc cggctcaaaa ggaatggcag
      901 gtgcatcggt actggccgcg cgtgcctgtc tgcgctcggg agtaggtctg ctgaccgtac
      961 acgcgccgtt atgcaacaac gatattctgc aaacgtccgc ccccgaagcc atggtagaag
     1021 cagatgtcag cgaaacatgc tttgccgtac ctaccgatac ggacgattac caagctgtcg
     1081 gcatcggtcc gggactcggt cgcaacgagg aaacggaagc cgccctgata gaacaactgg
     1141 aacattgtca gactccgacg gtactggatg ccgacgcact caatattctg gccaatcacc
     1201 ggcatacgct cacccatctg ccgaaaggtt ccatcctcac ccctcacccg aaagagctgg
     1261 aacgcctggt cggcaaatgt caggactcat acgaacgact gatgaaagcc tgcgaactgg
     1321 cgcacactgc caaagtacat atcattctga agggagctta ttccgccatt atcacccccg
     1381 aaggcaaatg ttacttcaac cagaccggta atcccggtat ggcaacagga ggcagcggag
     1441 atgtactgac aggagtaatc cttgcactcc ttgcgcaagg ctatcccgcc gaagacgccg
     1501 caaagatcgg tacttacatt cacggattgg ccggagacat cgcccagaaa aaacagggca
     1561 tgatcggatt aatcgcaagt gatatcgtca cctgtctgcc gacggcatgg cgacttgtaa
     1621 gcgaataaaa gttaagaact tacggtttat tcaataactt cattaacttt gtttttcaaa
     1681 atcagctaaa aagaaccgaa tatgaaaaag ttaatcatag caacaggact actaatggca
     1741 acttccgcct atgcgcagac cgaagtgctg acaggagtga cgcgaggaaa agactacgga
     1801 gtagtgtacg ccctccccaa aacccagata gaaatagaaa taaaagcaaa caaagtcaac
     1861 tataagccgg gtgaattcag caaatacgcc gaccgctacc tgagactgac caacgtctct
     1921 gccgaacccg aagaatactg ggaactgaac agtgtcaaag tgaaacctgt aggtgtacca
     1981 aacagcgaag ctacttattt cgtcaaactg aaagacaaaa ccgtagctcc tcttatggaa
     2041 ctgactgaag agggtcttat caaatcaatc aacgtcccct acagcagtaa caatgcaaag
     2101 aatgcagcaa acaatgccgt tgctccccaa cgaaaagcca atccccgcga ctttctcaca
     2161 gaagaaattc tgatggcaag ttcaaccgcc aagatggccg aactggtagc aaaggaaatc
     2221 tataatatcc gcgaaagtaa aaacgcatta ttgcgcggac aagcagataa tatgccttcg
     2281 gacggcgcac agctcaaaat catgctcgac aacctgaatc ttcaggaaga agccatgacc
     2341 gagatgtttt cgggagtccg caataaagaa gaaaagacat ttactgtccg cctcactccg
     2401 gataaggaat tcgacaatga ggtagctttc cgcttttcaa agaagctggg tatagttgcc
     2461 aacaacgatt tggcaggcac tccattctac atcagtctga aagacctgaa aacggtgaag
     2521 attccgcaag aggacgggaa aaagaagaaa gagatggaag gcattgctta taacgtaccg
     2581 ggacaggcaa tggtgacgct gacggacggc aaaaagaaat tgtatgaagg agaaatacct
     2641 gttactcagt tcggtatcat agaatacctt gctccggtat tattcaacaa gaactcgacc
     2701 atcaaagttt actttgatcc ggtgaccggt ggactactga aagtagatag agaagaaagc
     2761 aaataaaacc tctaaaaaaa caaaacgatg ggtggcgaag gacatatgct cgacatgata
     2821 cgtcggctga aagacggcaa agaagcctcc cgcttacgcc gtgaacggag aaatgacaag
     2881 ttagggcgac ttagaagaaa caacgaccct tatcttctgc cggatacgac tccggaagag
     2941 atggaacgca tcatcaagga ttcggaaaag aaaaaagaaa aagataacag ctatttcgta
     3001 tggggaacgc ttatcattat gggcgtactg ataggatgtg ctgtcctcct gtgggcaatc
     3061 ttttttaatg gataattatc catttaataa atccgtcttt ctgtaattgg gaaagatagg
     3121 tagatacacg agactcgtag cctgcttcat attgaaagtg gtctgcgagt ttttctataa
     3181 tctcacgaac cgtccgctgc ccgtctatca ggttccatac agccgtaccg tgttcttcca
     3241 gacgcacatg aatatctttg gacattcctt tcggcaataa ataacgactc atccacgaac
     3301 gtttaaaacg agggaaggag agcacaatag tctccccttc ctgttcagct ttaatatgtt
     3361 cgttacgaca agggatcacc tccaggaggt ttattttctc tttcgttgcc atatcttttc
     3421 tcttttatat cttttcagat agaatatata ctgtgattat ttctgaatat ttgcttcttc
     3481 cagtccgtag cctttcttct tgttttctgc tttcagcatc aaggcaacaa tcagggcaag
     3541 tacaccgaac atagcaaaaa tagccatcgg caaggtataa tcataagtct gtgcaccatc
     3601 tacaaccgga cctttgcaat aagaattcaa cacccatcca atcagcaaag gcacgcccat
     3661 caatccccag ttctgtaccc aaaagatcaa cgcataagcc gttcccaact gtttctccgg
     3721 aataatcttc ggaaccgaag gccacattgc cgaaggaacc aatgagaaag caaatcccag
     3781 aataatcatg atcaccgttg caaaccacca gatattcaga ataggaagag cgaacatagt
     3841 gtgtacgaaa atcagcatca ccgacccgat caccatcagc gtggctccct taccgatacg
     3901 gtcatacaat gacccgaaca acggtgtcag gatgatcgcg ccaatcggca gcaatccggg
     3961 aatcgttccc gcaagtttcg gatctacatt gtacttctgt accatcaaat cagccgcata
     4021 cttgatgaag gggaatacag ccgaatagaa caatacgcac agtaatgcga tcagccagaa
     4081 tcctttgttg gtaatgatat atacgatgtc tttcatgcgg aaaggttctt ccggttccag
     4141 tccttccgca tccagtgaag catccagttt cttatcatag aaagtataga tgaagaatgc
     4201 gatggtacct acgcacagca tgacgagaca gaacagaatc ggagcgggaa tattggtatg
     4261 gaatacgccg ctctcatccg tagacccgaa gaagtctgcc aaaggaacgg taagcaccat
     4321 ggccaaagtt gttccaatac gcgcggtcgc catttccagt cccatagcga gagccatctc
     4381 tttgccttta aaccacttca cgataatctt cgaaacggtg atacccgcaa tttcgactcc
     4441 tacaccgaaa atagcatagc ccaatgcagc caatgtgact tgcatcttga atccgaaaag
     4501 catcgcacct tccgggaaag tagtagtaat agcataatat ttcaatccac aaccaaacac
     4561 catcaataaa caggcaccca ttccggtgaa gcgtactccc atcttatcca gaatgatacc
     4621 accaaagatg agcatcagca ggaatacatt aaaccagcca taagcactgg tgaaaaaacc
     4681 gtaatctaaa ctgtcccaga gaagttcttt ttcaagcatg ggtttcagag gagacataac
     4741 gtctgtgagg aagtagccgc acaacatggt aaaagcgact aatgctagaa cactccaacg
     4801 cagcactgcg gagtcattca gcttttgttt caattgttct gtcattgtaa tatttaaaag
     4861 gagttaataa tctcgtaacg ggcaacaaag ttaactaatt atcatttgtt ttactaaaaa
     4921 aggagaacat tttataagaa aaaggacatc tgaccggata ttcctgtatg aagaagagca
     4981 gaccggaccc aataataaag ataggcgcga accacacgta ttacacaatt ctattagaat
     5041 ctcttgtaat tcgcgtaatt cgcgcctata atgaagagaa cgggtcaaaa agcccgttca
     5101 ctcaataagt ttaaaccgaa tatcctgtca ctgaattatt ctgctgcagg agcaggagtt
     5161 tcagtagccg gagcttctgt tgctggtgca gactctgcag gagcagtagc gtctgtctga
     5221 ggagcagcag taccggtagg catattatac ggattggttt gttgttcttt ctgtgcttgt
     5281 tccaacaata catctttagc tgcagaagaa gaaggaacaa cgtaagcagt agcaacgctc
     5341 atcacaacca tgaagatagc cagaccccaa gttgcttttt ccagaaaatc tgtagtcttg
     5401 cgcacgccca tgatagcgtt tgatgaagaa aaaccagaag caagtccgcc tccttttgaa
     5461 ttctgaatca gcacgatgaa gcacatcagc aaggctgcaa tcaccattaa gataatgaat
     5521 aataagtaca tttttagtta ttttgaatta gcgttaataa tcaatttctc caaaaatctg
     5581 atttggtctg caaagtaagc attttttttt ggatatttca agcttaattt tttaattatt
     5641 tcaagagctt tcgaatatcg ttgctgtttt acgtagattt tggccaaagt ttctgtgaaa
     5701 cagctgtcat cttcctcttc tacggtgttg gtttcagttg tttcgtctgt tctgcccgtt
     5761 tcgtttgttt cagcggaaga agctgccttt gctttctctt cttccttcaa aggtttcagg
     5821 tatacgactg gatcagtctc gcttttttcg ataaagttgt caatcagctc gtgtcctttc
     5881 aacttgggca ttgcctctgc cggctcatcg acgacaggtg tctcttcgag aaggtatgcc
     5941 gtatagtcca tggagtaatc aaagcttgtc tgactggtta cttcttcggg agccgtcgaa
     6001 aggaaagcat cgatcagagc cagtgtccgg tcgacggtag gctcatcttt caatacttca
     6061 gagagaggca gccctttctt ctgggattcg acagcgaagc gttcgccttc gatcagatga
     6121 aacagtttcc gtcggtcggc aatatacaga acggctttcc gcagttccgc accgaaatta
     6181 atgtcgtgga gaatatacag gttcttgaga tacaacaacc ggagcgactg aaaatacgga
     6241 tacctcgcga gctggttgcg cagttcgtac aaagtatccc tattcagcgt ctcgggatgc
     6301 tgaatccatt gttgcaagtt aacagaagtc attaaattac cagtttgcta cagttgcatt
     6361 aaatatttgg tcggttatct ctttactcat ttccgctatt aatccatcct gtacggctgt
     6421 cagcagctgg ctggaatcat aggtacgaaa agctgagaat tgttgttcga agtcttcggc
     6481 gtgatttgtg ttgttgacaa agcgtacatt gaccgtgatg gtcagcttcg tttccgaaga
     6541 gtaaccatcg gcagacactg cctggttata ctggttgtag cccgtaattt caccgtcaat
     6601 ctgcagatcc gcattctggt tcggttttag cagttgcaga cgggtctgtc tgatgaagat
     6661 atctttcagg tcttcattga acttggtagc cagcggagca tacacatact ccgacttaat
     6721 cgggaaatca gcaatcgaaa tggtcttcac cttatcgtaa ttgatagagg agccattaaa
     6781 cttataggac acactacagg cgatgatgac tgccggtaaa acaaccaata tcagcggtcg
     6841 tgctattttc ttaatccaat tcatattctt ttatttttct gtaaagggta cgctcggaga
     6901 tattcagatc cttcgccgca cttttccgct taccatgatg cctctcaagc gctttacgta
     6961 tcatttcttt ttccacttca tcgagcgaaa gggtttcttc cacatactct tccgtgtcct
     7021 gaatatcgtc atcgtcttct ttgggacaaa cagacggttg ctgcacagca tggattatgg
     7081 ccggcacgga aggttggtgc gtcgttgtca ctaccggagt agctactacc tgtcccatct
     7141 gtccgacttg tcccgcacgt tcggccatca tattgtgcac catcttcttc agttccgcca
     7201 cttcctgacg catatcgaac aagacagaat atagtatttc gcgttcgctc tcaaagctct
     7261 tgctctcgcg tgtgccgaac agtgccggaa ggcgttgggt attctgtgcc ggaagatagg
     7321 tctgcagaat cgcagccgtt atctcacggt ttgtttctat aatcgaaatc tgctctgtga
     7381 tgttcttcaa ctgccggacg tttcccggcc acggataagc aagcaatatc ttcttggcat
     7441 cttccgtcag ctggatagcc ggcatccggt acttttcggc aaagtctgcg gcaaacttac
     7501 ggaacaacaa cagcacatca tctccacgct cacgcaaagg tggtatctga ataggcaccg
     7561 tgttcaaccg ataatacaaa tcttcccgga agcgtccttc ggcaatggct tgtgtcaggt
     7621 tcacgttggt agctgccaca atacgtacat ccgtcttttg cactttggat gaacctacct
     7681 tgataaattc accgctttca agtacacgga gcagacgcgc ctgtgtaggc aacggcaact
     7741 ctcccacttc atcaaggaag atggttccac cgtcagcttc tccaaaatat cctttccgct
     7801 caccaatagc accggtaaat gctcctttct cgtgtccgaa cagttcggaa tcgatcgtac
     7861 cttccggtat ggcaccacag ttgacagcaa tatactgccc atgctttctc cggctatatt
     7921 gatgaatgat ctgtggaaaa ctttcttttc cgacaccact ttctccggta atcagcacag
     7981 acaaatcggt aggcgctacc tgaatggcaa catctatggc acgtgataag gcctcggtat
     8041 tgccaataat accgaaacgc tgtttcactt gttgtatctc tgctttggtc atctatctta
     8101 atattaagta ataggtaata agtattaagt aataagtatt aagtattacc atcactatca
     8161 tctcgcttct atccgcatgg ctaatactta atacttatta cttaatacct attacttaat
     8221 cttcgtctac tgtatccagt tttagtttat cactatcgtc ccgtttctcg taatactgct
     8281 tccgcaacgg gtttacccgt gctgctttct cgcgctggcg gttgcggaat acatcaattg
     8341 ctacataaat agcctggcgg aaagagtctt cgctggccag tcctttaccg gcgatgtcat
     8401 aggctgttcc atgagccgga gaggtacgta caaccggcag tccggcggta tagttcacac
     8461 cgtcttccat agccagggct ttgaacggag ccagtccctg atcatgatac atagcaagga
     8521 ttccgtcaaa gtgggtataa ttgcccgaac ccataaaacc gtccgcagca taaggaccgt
     8581 aacagatgat ccctttctct tccatttctt tcatggcagg gataatgatt tcctgttctt
     8641 ccatacccag cagtccgccg tctcctgcat gaggattcag tgaaagcact gcaatacggg
     8701 gcgcaccgat accgaaatcc tgtttcaggc aacgatggaa aatcatcagc ttttcctgaa
     8761 tcagttcctt ggtgatcgtt gtggcaatct cccttaccgg aatatgcgtc gttactaaag
     8821 ccacacgaaa atcgtttttc atcaggatca tcagtgactt gtttccatcg cccagacgtt
     8881 cttcaatata ctccgtatga ccggggaaag agaactcttc cgactgaatg gtatgtttgt
     8941 tgatcggagc tgtcacaatg acgtcgatca gcccctcacg atactcttct atggcacgtt
     9001 ctaaagcacc caatgcagcc ttacctgctt cgggatcggg tttggagaat tccactttca
     9061 cttcgtcatc cgtacagttc actacactca gacggttgta tccggcttcg gaagctgtgt
     9121 tgacaatgct gaaattagcc tgtacatcca gtgctttacg atggtaagcc gctactttag
     9181 gtgaaccgta gataatcgga gtacatagct caagcatggt agggtctgag aatgtcttca
     9241 agatcacttc ataacctacc ccgttgatat ctccttgggt aatgccgatt cttattttgt
     9301 tttcttccat gtttttattt attagttggt tccgcttctt tggttacccc cagtggaatc
     9361 tggctctgct gaccttcttg cggaagtttc agcgtataaa gagatgcttc catctggcga
     9421 accagattgc gtttcatttt atcgggtgaa tatacaaata tttctgctgt aataatacgt
     9481 tggttcttct gatccagacg agtatgggaa acgaacggcc cacccatgaa gtcacccttc
     9541 atgcgccaca atccacgagc ttccatcgtg tagtcattgt gcacgttgat cggacgaaca
     9601 tcggtcagta acgagtctgt cgacatatat acgccttctt tatatccggg gatattggct
     9661 ttcatcacgg aatcgcgctt atgaacaaag tattctttgg tgaatgtatc cttgtcagta
     9721 taaggataag aatacatcac gaaattgcga tccgcgctgc ctgtattggt agatgcccag
     9781 aagaagtcct ctcctgtctt ggagttattc agttcggaag gtatccagat atcgcagcca
     9841 aacagactat ctaccttatt tgagataaag ttgttgtgct tttcctccag caaagtaatc
     9901 tgacggttca tttcagcgcg agtgaagaag tcgataatcg tctgcttatt ttcttccaca
     9961 aacttctcaa acacttcttc gttcggagcc tgaatggtca gtatcatctg tggagaagca
    10021 taaacgtctt tcgcatactt gaaagtacct ttggtataaa tatcttttat atctactatc
    10081 acaatattac ggatcaactt cagcgtagaa tcatagtcct tcggtgaagt atacataatc
    10141 cggaaagaag gttccgactg gggcagtccc ggcatgtcag aatcaagcac atcatgcaag
    10201 gcccttccgg cggcacggtc ccacactccc gcatctacta caaccaacag ttcatacgga
    10261 cgaccgctag aggtatgatt cccctttaat ccacaagaag caactacgaa ggctaccaga
    10321 gccatgctta aataaaaaaa gtactttttc atgatgttcg atttttatat taacttttat
    10381 tattttcctc ctgtttcgca gtcgacagca taccgcatgc cgcaaaaata tcctctcccc
    10441 gcgaagcacg aatggtagtg aaaagcccgt gcgtggtcag atagtcacgg aaacgggtca
    10501 tcgtatccat atcggctcct tcaagggcta ctcccggaat agaatggaaa cggatcaggt
    10561 taatccggca atccagtccg cgaagcagtt tgagtaactc cttggcataa acttgcgaat
    10621 cattaagccc cttaaaaaca atatactcaa acgaaagtcg acgctgtttg ctaaaatcat
    10681 agttttttaa cagttccacc atttccgtga tagaaaaggc tttctccgcc ggcatcagtt
    10741 ccgcacgctg ggcggtcacc ggagaatgca ggctgatggc aagatgacag tcgctttctt
    10801 cgataaagcg ccgcaatcct ttccgcaatc cgacagttga aacggtaatc cgcttcggac
    10861 tccatgcata accataggat ccagtcagta tgtccaatgc cttcaacacc tcttccagat
    10921 tatcgagcgg ttcgcccatt cccatcatga cgacattcgt cagtttgtcc cgttccggca
    10981 aggagtgaat ctgattgata atctgatggg cggtcaggtt ggcagagtag ccttgtttcc
    11041 cggtcataca gaacttgcag ttcattttgc agcctacctg cgaagagatg cataaagtcg
    11101 cccgttcatc atccggaata tacaccgact ccacaaaatg attctcgccc acagggtaca
    11161 ggtatttcac cgtaccgtct acagagcgca tttcctccac cggagcttca gctcctacct
    11221 catagttctg cttcagtaac tcccggtatt tcaacgacaa gttagtcatt tcatcaatcg
    11281 aagtcacctt cttatcataa agccaggatg caatctgttt ggctgcaaag cccggcattc
    11341 ccagacgttt caccagtgac tgcagctcta taagcgtcat tcctaagagg ggatatttag
    11401 acatcattct ttctgttcat ggtttatatt tgcaaatgta aggaaataaa gtcgatttcc
    11461 gtatagcaag gatgtaaaag ttagcaaaaa aggtcgttcc aaagcatgga acgacctttt
    11521 gcagttatcg attttacgac taatcttaga agaacaggta acgtgtatcc ttcacttttc
    11581 ctttcagata caggtcgttc atcagacggc ttgcgaagcg tgcgtgcatg ttagccaatg
    11641 tagcttcttc atctttagcg ttgaaagtat cgctcagttt gtctttgcca tacatctgaa
    11701 gcacaaatac accggcatta cctttgatcg gagcgctcag tttgttcatt tcagccacag
    11761 aagcataagc acctaccaac ggttcgctgc tgcgcaatgc agaaacataa gcgggagcgg
    11821 caaatgtaac cagcttcaaa gaatcgctga ctgcgccgga catagccttg tactggtcga
    11881 gagaagttgc attggcagcc ttcatgtcag ccatgatctt ttcggctttc ttatctttaa
    11941 cgatttcagc tctcaactga tcctgtacag cttttagcgg acgatatcct tccggagtaa
    12001 caccaaccag agctactgca accatatggt cgctttcgcc acattcatac aaaccggaaa
    12061 catcacccgg tttagcggca aatgcccatc tcaatgcttc tttagtacct cttacaccac
    12121 cgatagtgtg ttctgagcta tacaagtctc ttctgtcaag cagtttgtat ccggcttctt
    12181 cagcgttagc gatcatcttt tcagcagtag gattggcagc gatgaactgg ctgaaatcat
    12241 tgtaagcacg attataagtc tctttgctga attcaacttc acgtttcaca acagctactt
    12301 tatatttatc cttcacagct ttcttgttag tcacttgcag gattacatta gcttgtccca
    12361 acggcagatt tactacttcg ttcacgcctg tattattgat agcagagata aacttcaggt
    12421 tgtcaccatc gatctgtgcg ccttcatact gtgcagagct catccagtta gtctcacccg
    12481 tctgaccgta tttcttagcc agatctgcga agttagcacc gcctttgata gcagtataga
    12541 tactgtccgc caaggctttt gtcttcaaag cgtcttctgc aaacacctga atctgacgga
    12601 actcgattga gtcggcagca gctgtttttg caaccacttt gaatgaattg atagtattgt
    12661 cggcaccatt atagtacgga ccataaacag aaccaacgga tgcagagtcc agacgggcaa
    12721 ctacatctga cgggaaagct gttttattat agaacaagtc tacataagga gcttccgagc
    12781 ctacagaacg gataaaagaa gtatagtcat ctgttgtagt agccagctgt gcagtagctt
    12841 cgtctacttc ctgctggata gcagctctgt cttccgcact tgcagtcacc tgaacatcaa
    12901 tgtacttgat atcacggctt tcctgatatt gcttgaactg ttcttttttc ttgttataaa
    12961 ggtctttcag ttccgattct ttcacaacga ttgtagaatc tactatagaa gaataaggaa
    13021 cggcagccat caacaaatca tattgattca ctcttgcgtc gaaagcgtcc tgtgcttcta
    13081 ccgggttaga gagaagcgct tttgctacca atgcctgata tttttctgcc aggcggctct
    13141 gaatcaatgt cttctggatg aatgaccagt atttgtacat gttgttgtac tgttctgcat
    13201 actgagccgg catctgagat tcgttcattt tagcgtaatc taccaggaac ttattgagca
    13261 tatccttatc gaaagcaccg gtctgcgggt tgcggaaagg agtctgttgc aacaacggat
    13321 gcacgcctgc tttcaggata tcctgaattt cagcagcaga aactgtcagt cccaatgctt
    13381 ttgcttcttt ctcaaccagt ttgttattaa cg
//
