LOCUS       gnlProkkaIBEFILGH_62   11301 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IBEFILGH_62.
ACCESSION   gnlProkkaIBEFILGH_62
VERSION     gnlProkkaIBEFILGH_62
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 14:57:33
            Original ID  :: gnl|Prokka|IBEFILGH_62
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11301
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..765
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 35.2;
                     E-value: 9.5e-11)"
                     /gene_kind="transport"
                     /locus_tag="ctg62_1"
                     /transl_table=11
                     /translation="MDGFVIDGQPGFILQPYDEVYVRRSPGYQAQQNVAIEGEILFGGN
                     YAMTSREERLSDLVNKAGGPTNYAYLRGAKLTRVANASEKKRMGDVIRLMSRQLGEAMI
                     DSLGIRVEDTFTVGIDLEKALSNPKSNADLVLREGDVISIPKNTNTVTINGAVMVPNTV
                     SYMKGKNVDYYLNQAGGCSDNARKSKKFIVYMNGQVTKVKGSGKKQIEPGCEIIVPGKA
                     KKKGNIANILGYATSFSSLGMMIASIANLIKK"
     protocluster    1..11301
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[1987:6301]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1988..6301
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..11301
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11301
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             776..1924
                     /locus_tag="ctg62_2"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVFFGKSLLASLRKELKNKEIEQDK"
     CDS             1988..2707
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 54.5; E-value:
                     1.6e-16)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg62_3"
                     /sec_met_domain="NTP_transf_3 (E-value: 2e-16, bitscore:
                     50.8, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CDIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             2728..4029
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 208.9;
                     E-value: 1.5e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg62_4"
                     /sec_met_domain="CTP_transf_like (E-value: 2.4e-13,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 2.5e-121, bitscore:
                     394.2, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 2.8e-63, bitscore:
                     203.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKIILENERALEVRELCMPIKEILELIPGTK"
     CDS             4046..5170
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg62_5"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.3e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.2e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             5180..6301
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg62_6_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg62_6"
                     /sec_met_domain="Aminotran_5 (E-value: 1.9e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        5270..6277
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg62_6_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg62_6_Aminotran_5.1"
                     /locus_tag="ctg62_6"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             6298..6441
                     /locus_tag="ctg62_7"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYGNIN
                     LR"
     CDS             6644..8128
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg62_8"
                     /sec_met_domain="Polysacc_synt (E-value: 1.7e-31, bitscore:
                     99.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLKQKTVSGIMWSAIERFSLQGVQFIIQIILARLLLPSDYGMI
                     GMLAIFLQVAQVFIDSGFTNALIQKKDRTEEDFATVFYFNILVAVLFYGILFFSASLIA
                     DFYNMPTLVLVIRFIALSLIINALSAIHRTKLIISVNFKTQSKISLGAAFISGVIGIWM
                     AYVGCGVWALVWQTLLNSIILTILFYCLVHWKPLHTFSKSSFERLFNFGSKLLISSLIN
                     TVYRNLYTIVIGKKFSVVELGYYTRAEQFAIFPSNNLNALVSRVAYPILSSIQDDDKCL
                     TNAYRNYIRLSSYIIFPLMVGLLVLANPIISLLLTDKWSGVVILLQILCLDWMFDHLSQ
                     INLNLLWVKGRSDLSLRLEIIKKTIAIFILFVSIPFGLEVMCWGRVIYSLIATYLNTYY
                     TNSLIDLTLKLQVKDVFPSLILSFIMGGIVFICISFFETDIVKIVIGCITGMSFYILLS
                     FLFKLDSFFCILTLIIKTKNIDENIKKDFSSNSKDN"
     CDS             8082..9341
                     /locus_tag="ctg62_9"
                     /transl_table=11
                     /translation="MKILKKIFQVIVKIINHCVPVDSRSLYFIPHPNCRTDKYDIINYS
                     SDNVLVLLNYLLKKDSAEYYKIYVEIYDSSRISEYQEYIYGINPNIRCTFLCACVGRFF
                     FNKVSFKDMLYAFFCFCRASKCFTATFYYDFSFKKRSQQIICLGYYTPFKDDYHMGDHS
                     YDKFRNTTCNSFDYSIATSCLSARIISIDCGISYDKFKVLGFPRNDLLISKNNCNVIKR
                     EISKFAGYDVTKYIVYTPTFRDYETVTEGNLRSILGYVDCDLLKLSKILLKFNAALILK
                     LHPLQNKTVLKKDLPKGILVFEQTYKYGLYDLLSFSDGMITDYTSTYFDFLLVNKPVIF
                     NFYDIEEYRRVRGFSFEPIEFFCAGDIVYNYNELIDAVMGLLAGKDIHAEHRRHISLLM
                     NQFQDDNSTKRICDIFLNEI"
     CDS             9350..10099
                     /locus_tag="ctg62_10"
                     /transl_table=11
                     /translation="MNYAFVVQARLGSTRLPGKILKPFYGNQSILDLMVHKLSAISNIP
                     VIIATTNSVINEPIEKKALALGVKCFRGEENDVLKRFIDVAEYFDIQGIFRICSDNPFL
                     DVHAARQLVEIAMKSCNDYISFDIDGTPSIKTHFGFWGEFVTLDALKRVIGFTDDLLYR
                     EHVTNYIYSHPELFNIQWISGSPVVSKHHNIRLTIDTLEDFSVAQRIYRDLQEKRVEIS
                     IEVIVDYVRRHAEYIQLMKQQIKKNSK"
     CDS             10099..11139
                     /locus_tag="ctg62_11"
                     /transl_table=11
                     /translation="MKNTYIIGEIGQNHNGSVDLAKLIIELISRPVHEDVFGMDFMPMN
                     AVKMTKRDLSEELAVSQMNQIYDNPNSFGRTYGEHRAFLELDDQAHFEIYKYAKSLGLD
                     FIETLCAKGCLSLLKLFTPDRLKVASRDLTNLPLLEALAETHIPIILSTGMAGQRELDN
                     ALDVITRYHSNIAILHCVSQYPTHPNNLNLRTITYLKKHYNKFEIGFSDHTIGISAATA
                     AVAMGAEIIEKHVTIDRHMKGTDQLGSLGPDGVNRMIRDIRIAECWLGTEDLYIEKGVE
                     KSKIKLERSIATRKYIPAGSIIQESDIHLLSPGDGYKWIDKKNVIGHFAKQDISANEII
                     YPDFIE"
ORIGIN
        1 aaggatggtt ttgtcatcga cggtcagccc ggttttatcc ttcagcctta tgacgaagtt
       61 tatgtccgtc gcagtccggg ctatcaggca caacagaatg tagccattga aggtgaaatc
      121 cttttcggag gaaattacgc catgaccagc cgtgaggaac gtctttccga tttagtgaat
      181 aaagccggcg gtccgaccaa ttatgcctat ctgcgtggtg cgaaactgac ccgtgtggct
      241 aacgctagtg aaaagaaacg tatgggtgat gtaattcgcc ttatgagcag gcaattgggc
      301 gaagccatga ttgactcttt gggtattcgt gttgaagata cttttacggt tggaatagat
      361 ttggaaaaag ccttgagcaa tcctaaaagt aatgccgatc ttgtcttacg tgaaggtgat
      421 gtgatctcca tacctaagaa tactaatact gtaactatca atggtgctgt catggttccg
      481 aatacggttt cttatatgaa gggaaagaat gtggattatt acctgaatca ggccggtggc
      541 tgttctgata atgcaaggaa gagtaagaag ttcattgttt acatgaatgg tcaggtgacg
      601 aaggttaagg gtagtggtaa gaaacagatt gagccggggt gtgagattat tgtgcctggt
      661 aaggctaaga agaaagggaa catagctaat attttaggtt atgctacttc cttcagttct
      721 ttgggaatga tgattgcttc tattgctaat ttgataaaga aataaatgac ctattatgat
      781 tgaaaagcaa tcttatcaag aaccgttttc tgaagtggat aaaaggaaag atgatgaaat
      841 ggaaatagac ttgatggcta ttttttataa gattattact gttcgtggag tactatgcaa
      901 agctgctgga gtgggagtaa taattgctat agtggtggca ttgagcattc ccaagcaata
      961 tacagtaaag gttacccttt ctcctgaaat gggtaatgcg aagggaagta atggtttagc
     1021 cggacttgct gcctcgtttt tgggagatgg ggctctaata ggggaaagca cagatgcctt
     1081 gaacgcttct ctttcagcag atattgtttc ttcaactcct tttttattgg aacttttaga
     1141 aatggaagtc tccgtttcta aaaaggatga taaaatgact ttggggtctt atctcgatga
     1201 agagtcatct ccttggtggg attatcttat aggttttccg ggcatagtaa taggaggagt
     1261 taaatcatta ttcggagaag atacggttcc tgccagtgga gggcggcaag gaactatcga
     1321 attgacgaaa gaagtaaatg agaagattaa ttttcttaaa aagaagatta gtgcatccat
     1381 tgataagaaa accgccataa cgagcattac ggtcacctta caaaatccgc agatcactgc
     1441 ggttatagca gattctgtcg ttcataaatt acaggaatat attattgggt atcgaacttc
     1501 aaaagtaaaa gaagactgtg cgtatttgga acggttgttt aaagaacgtc agcaggaata
     1561 ttatgctgct caaagaaaat atgcggatta tgtagacgcc catgataatg tggttcttca
     1621 aagtgtacgt gctgagcagg agcgtttaca gaacgacatg agtttggctt atcagatata
     1681 tagtcaggtt gctaatcagt tgcaggtatc cagagccaaa gtacaggagg aaaagccagt
     1741 ctttgcagta gttgagcctg ccgttgtacc tttgaaacct tcaggtatgg gactcaaaat
     1801 ttatatttta ttatttgtgt tcctgtccgt atctggtact ctcgtgtggg tgttttttgg
     1861 caaaagtctg ctggctagct tgagaaaaga actgaaaaat aaggagatag aacaggataa
     1921 atgatgctaa aacgtcgttt acaacattct tacatcaatt aaattcactt actatattat
     1981 taaacgaatg atacgtacag ctatgataat ggctgcgggc atgggaaccc gttttggcca
     2041 atatacagaa ttgataccta aagggttcgt caaagtggga ggtattccaa tgatagttcg
     2101 ttctattgat actttgttat catgtgacat tgagcgaatt gtaatcggta caggatataa
     2161 acaagaagtt tatgaagaat tgaagacaga ctatcctatg cttgaaacct gttttagtcc
     2221 tcgttatgct gaaacaaata gtatgtatac tttatataat acgcgggaga ttctgggcaa
     2281 tgatgatttt ttattgttag agtcagattt gatttttgag aaacaagcaa taatgagctt
     2341 attggagtgt cctgcggcag atgcaatgct aataactcca gtgacaaagt ttcaagatca
     2401 gtattatgtg gaacatgatg ataattttcg cctttcttca tgttctgtca ataagaataa
     2461 actaaacgct aaaggcgaat tggtcggcat ccataaacta tccggttcct tttacaaaat
     2521 aatgtgtgct gattatgcga gtattgttga tgaacaaccc aatttgggat atgagtatga
     2581 attactacga atatcttgtt ctcaatctcc tgtttatgtg cataaagtag aagggctgaa
     2641 atggtatgaa atcgatgaca tatcagattt ggaatatgca gagaaatata ttgttccgta
     2701 ttgttaatta aaataatata tcaaattatg agtaagacag tttatattgg gatgactgcg
     2761 gatattatgc atccaggact tatccgcatt attaatgagg ctactaaata cggtgatgtt
     2821 ataattggtc ttcttacaga taaagctatt gcggagcata aacgccttcc ttatctgacc
     2881 tatgaacaac gaaaagaggt agttcagaat attaaaggcg tatgtaaagt tgttcctcaa
     2941 gaagaatgga gctatgttga gaatctcaaa cgcattaaac ctgactatat aattcatggt
     3001 gacgactgga aaaccgggcc tttacgtgaa gaacgtgtgc gcgtatttga agtgatgaat
     3061 gaacagggag gaaaggttat cgaaattcca tatactttgg gaattaattc atcttctttg
     3121 gataaagata ttaaggctat aggtacaacc cctgatgtac gtttaaaatc acttcgtcgt
     3181 ttgataaatg ccaaacccgt agttcgtatt ttggaagctc atgatggact atgtggcttg
     3241 ataattgaaa atcaggaaat attaaaaggg gataagaggg aagtatttga cggaatgtgg
     3301 tctagtagcc ttacggattc aaccagtaaa ggtaaacctg atattgaggc ggttgattta
     3361 actacccgat tgcaagattt gaataatatt ctggagtgta ctactaaacc tattattttt
     3421 gatggagata caggtggtaa aattgaacat ttcgtattta cagtacgcac tttagaacgt
     3481 catggaattt cagctataat aattgaagat aaagttggat taaaaaagaa ttcattgttt
     3541 ggtacagatg ttattcaaac tcaagataca atcgaaggtt tctgtaataa gatcaaagca
     3601 ggaaaggcat ctcagattac tgatgatttt atgattatcg ctcgtattga gagccttata
     3661 gcgggaaagc cggtaagtga tgctttagag agagcttttg catatgtcca agcgggagcg
     3721 gacggtatta tgatacatag caaaaataag tcgggtgaag atataaaaga attttgtttg
     3781 gcgtttcgaa aacagtatgc tcatgtacct atcgtggttg tgcctactac atatgatcat
     3841 atttatgagt ctgaattgtg tgattggggt gtgaatataa ttatttatgc taatcatatg
     3901 cttcgtgccg cttatcctgc tatgatgaat gtcgcaaaga taatattaga gaatgaacgt
     3961 gctttagagg tgcgcgaact gtgtatgccc ataaaagaaa tattggaact gattccaggt
     4021 actaaataaa aagaggaata tcattatgtt aagcgtagaa aaagtttatg aaacgtttct
     4081 gagtcatgac gttgattttt ttacaggagt tccagactca ttactaaaaa atatttgtgc
     4141 ctatatcaca gaccatactt cacgtgagaa acatatcata gctgctaatg aaggtgcggc
     4201 tgtaggaatt gcttcaggtt attatatggc atcaggtaag gttcctgtgg tttatatgca
     4261 aaattccggc ttgggtaata ctgttaatcc tctgctgtct cttgcagatg aacaagtata
     4321 cagttttcca atgcttttga tgattggctg gcgtggtgaa ccgggaacaa aagatgaacc
     4381 tcagcataaa aaacagggtg aggtaacttt agatttgttg aaagcaatgc ggattcctta
     4441 tataattctt gattcaaatg agaatgatgc atttattcag ctccatgata tcatacaatc
     4501 agcaaaaact aagaatattc ctcatgcaat aattattcgg aaagatgttt ttggcaaata
     4561 taaacttcaa aaagagttcg gatgtaatta tcctttatct cgtgaggatg ctttgcaaat
     4621 agttgtggat tatctgcctg aaaattcagt ggtcgtttct actactggca agctttctcg
     4681 tgagttattt gaatatcgag aaatgaaaga gcaaggtcat gaacatgatt ttctcacggt
     4741 aggctctatg ggacatagtt catcaatctc tttgggtatt gctatagcaa agcaagatag
     4801 acctgtttat tgcttggatg gtgatggagc atttattatg catttagggg caattagtaa
     4861 cattggcgat ttatctccta aaaactatta tcatattttg tttaacaatg gtgctcacga
     4921 gtctgtagga ggacagccta ctttaggatt tagtttagat attccggcta ttgtccgggg
     4981 gagcggatat aagcatactt atactgtttg tacaaaagtt gaaattgaag aagcaatgaa
     5041 gcagcttcca aagttatgtg gtcctgtttt gttggaaata aaggttaaaa tagattctcg
     5101 ggagaatttg ggacgtccca cgactactcc tatagagaat aaggagcatt ttatggattt
     5161 tttaaaataa atatattcga tgaaaataga aagaaaaata ttattaaatc ctgggcctgc
     5221 cactactact gacagtgtaa aaatggcaca agttgttccg gatatttgtc ctcgcgagaa
     5281 agaattcgca ggtatgatga aacaacttcg ggacgatttg gtcagagttg ctcatgggaa
     5341 tttggaaaaa cataccgctg tattattttg tggctcagga accatcaata ttgatatatg
     5401 tctaaattct cttcttcctg aagacaaaag ggtgcttata gtgaataatg gggcatatag
     5461 tacccgtgct gtagaagtgt gtcaatatta tggtttgcct catattaatt tggaattttc
     5521 cgtttacgaa cgtcctgatt tatcggtggt ggaaaatgtg ttgcaagaaa atcctgatat
     5581 agctatggtt tatactactc atcacgagac gggtacagga attctgaacc ctattcgcga
     5641 gatgggcgct atagctcata aatatcaggc taaatttgtc gtcgatacta cttcttcttt
     5701 gggcatgatt ccttttgata tagagaaaga taatgtggat ttttgtatgg catctgctca
     5761 aaaaggactt caagcgatga caggtctttc ttttattata ggcaatgagg aacagattaa
     5821 gttttcaaaa aaatatccca agcgttctta ctattgtaat ctttatttgc agtatgagaa
     5881 ttttgagaga acaggtgaaa tgcattttac tccaccggta caaactattt acgccactcg
     5941 tcaggcatta aatgaatatt ttgaagtggg tgaagaagct aagtttgccc gtcacaaaag
     6001 agtttttgag gctattcatt caggtataaa tgaaattggt cttaaaagtg taataaagcg
     6061 tgaatggcag tcaggactgg ttgtctcagt tcaataccca gaagatccca actgggattt
     6121 tgagaaaata catgattatt gttatgagcg tggatttacg atttatccag gtaagatatc
     6181 aactgaggat acttttagaa tctgtgcttt aggagagata gaagtagatg atattgagaa
     6241 cttctttaaa gtactaaaag ctgcattaaa tcattataac gtcacattac cgatgtcatg
     6301 attgcagaaa tattattgaa gattcgtcat ttttattttt cccttcgtgg tatacacttc
     6361 catccggaaa gtgttatttc tggagtgcct attcgtagct ttcgcttagt aggcaaatat
     6421 ggcaatatta atttgaggtg atgcattagg agttctttat tcttataaaa aggcatcggt
     6481 agttatagga gataatgttt gtgtagggta atttgctttt agtgggagag accatattag
     6541 aattgcggta aggggcgaag aagataataa ccaattagtg agaatattgg aaaaatataa
     6601 ttgatatcgg taaatgtagt tgtttttata ctgtatttaa gtaatggaaa atctaaagca
     6661 gaaaactgta tcaggaataa tgtggagcgc tatagaacgt ttctctttac aaggagtaca
     6721 gtttataatt caaataatat tagctcgttt gttactacca tcggattatg gtatgatcgg
     6781 gatgttagct atttttcttc aagtcgctca agtatttata gatagcggtt ttacaaatgc
     6841 tttaatccag aaaaaagata gaactgaaga ggattttgcc actgtctttt attttaatat
     6901 tcttgtcgca gtattattct atggtatatt gtttttttcg gcttctttga ttgcagactt
     6961 ttataatatg ccgactttag ttcttgtaat tcgttttata gcattgtcgt tgataataaa
     7021 tgctttatcg gctattcaca gaacgaaatt aattatttct gtaaacttta aaactcaatc
     7081 taaaatttca ttaggtgcag cttttatatc aggcgtgatt ggaatatgga tggcttatgt
     7141 cggttgcggg gtttgggctt tagtttggca aactctctta aatagtataa ttttgacaat
     7201 tttgttttac tgtttagttc attggaaacc tttacatact ttctccaaaa gttcttttga
     7261 aagattattc aatttcggat ctaaattatt gatctcaagt cttatcaata cagtatatcg
     7321 taatctgtat accattgtaa taggaaaaaa gttttctgtt gtagagcttg gttactatac
     7381 aagagcagaa caatttgcta tttttccttc caataattta aatgctttag tttctagagt
     7441 agcgtatcct attttaagtt ccattcaaga tgatgataaa tgtttaacaa acgcatatcg
     7501 aaattatatc agattatcct catatataat ttttccttta atggtaggtt tacttgtttt
     7561 ggctaatcct attattagtc tattgttaac agataaatgg tctggggttg ttattctttt
     7621 acagatatta tgtttggatt ggatgtttga tcatttgagc caaattaatt tgaatttatt
     7681 atgggttaaa ggaagatctg atctgtcgtt acgtcttgaa ataataaaaa agacgattgc
     7741 tatattcatt ctttttgtgt caattccatt tgggcttgag gtgatgtgtt ggggtagagt
     7801 tatttactct ctgatagcga catatttgaa tacatattat actaattctc ttattgattt
     7861 gaccttaaag ttgcaagtta aagatgtatt tccaagttta atactctctt tcataatggg
     7921 ggggatcgtt tttatatgta tttctttctt tgaaactgat atagtaaaaa ttgtgattgg
     7981 atgtattact gggatgtcct tctatatttt actttctttt ctttttaagc tagattcttt
     8041 tttttgtatt ttaacattga tcattaaaac taaaaacata gatgaaaata ttaaaaaaga
     8101 tttttcaagt aatagtaaag ataattaacc attgtgtgcc agttgatagt agatcattgt
     8161 attttattcc tcatcctaat tgtagaacag ataaatatga tattataaat tattcgtcag
     8221 ataatgttct cgttctgtta aattatttgc taaaaaaaga tagtgctgaa tattataaaa
     8281 tatatgttga aatttatgat tcttctcgta tttcagaata tcaagaatat atttatggca
     8341 taaatcctaa tattaggtgt acttttttat gtgcatgtgt tggacgtttt ttctttaata
     8401 aagtatcttt taaggatatg ttgtatgcct ttttttgttt ttgtagagca agtaaatgtt
     8461 ttacagctac tttttattat gatttttcat ttaaaaaacg ctctcaacag attatttgtt
     8521 tggggtatta tactccattc aaagatgatt atcatatggg agatcattct tatgataaat
     8581 ttcgtaatac aacatgtaac tcatttgatt actctattgc tacttcttgt ttaagtgcta
     8641 gaataatttc aatagattgt ggaatctcat atgataaatt caaagtctta ggatttccca
     8701 gaaatgattt gttgatatcg aaaaataatt gcaatgttat taaaagagaa atttcgaaat
     8761 ttgcgggata tgatgtaact aaatatatag tttatactcc aacttttcgt gattatgaga
     8821 ctgttactga aggtaatttg cgttcaatac tcggatatgt tgattgtgat ttgttgaagt
     8881 tatcgaaaat actattgaag tttaatgcgg ctttaattct taaattacat cctttgcaga
     8941 ataaaacagt cttaaaaaaa gatttaccca aaggtatact tgtttttgaa caaacatata
     9001 aatatggatt gtatgatctt ttgtcatttt cagatggaat gattactgat tatacttcta
     9061 cctattttga ttttttattg gtaaataagc cagtcatatt taatttctac gatattgaag
     9121 aatatcgtag agtaagaggt ttctcatttg agccaataga atttttttgt gcaggtgata
     9181 ttgtttacaa ttataatgaa ttgatagatg ctgtgatggg acttctggct gggaaagata
     9241 ttcatgctga acatcgacgt catatttctt tattgatgaa tcaatttcaa gatgataatt
     9301 caacaaagag aatatgtgac atatttttaa atgaaatata ataaataaaa tgaattatgc
     9361 atttgtggtg caggcacgtt taggttctac acgtttgcct ggaaaaatat tgaaaccttt
     9421 ctatggtaat caatcgattc ttgacttaat ggttcataag ctttctgcta tatcgaatat
     9481 tccagtaatt attgctacaa caaattctgt tatcaatgaa cctattgaaa agaaggcact
     9541 tgcattaggg gtaaagtgct tcagaggtga ggagaatgat gttttaaaac gattcattga
     9601 tgttgctgaa tattttgata tacagggtat attccgaata tgttctgata atccattttt
     9661 agatgtacat gcggcaaggc aattggtcga aatagcaatg aaatcttgta acgattatat
     9721 aagttttgat attgatggta ctccatcaat taaaactcat ttcggttttt ggggagaatt
     9781 tgtaacgctt gatgcgctga agcgagttat aggatttact gatgatttat tgtatcgtga
     9841 acatgttact aattatatat atagtcatcc tgaacttttt aatattcaat ggatttcagg
     9901 atctccagtc gtgtcaaaac atcataatat tcgactcacg attgatacgt tagaagattt
     9961 ttctgtagca cagagaatat atagggattt acaagaaaaa agagtggaaa tatcgataga
    10021 agtgattgta gactatgttc gaagacatgc agaatacatt caactgatga aacaacaaat
    10081 aaaaaaaaat tctaaataat gaagaatact tatattattg gtgaaatagg gcagaatcat
    10141 aatggttctg ttgacttggc taagttgatt attgaattaa tctcacgacc tgtacatgag
    10201 gatgtttttg gtatggattt catgccaatg aatgctgtta aaatgactaa aagagattta
    10261 tcagaagaat tggctgtttc tcaaatgaat caaatatatg acaatcctaa ttcttttggg
    10321 cgtacttatg gtgaacatcg tgcttttctt gagcttgatg atcaagcgca ttttgagatt
    10381 tataaatatg ctaagtcatt aggattagat tttatcgaga cgttatgtgc caaaggatgt
    10441 ctgtctttgc ttaaactgtt cacaccggat aggctaaaag ttgctagtcg tgatttgact
    10501 aacttaccat tgcttgaagc attagcagaa actcatattc ctattatatt atcgacagga
    10561 atggctggtc aaagagaact tgacaatgca ttagatgtga taacgagata tcatagtaat
    10621 atagctattc tacattgtgt atctcagtat ccaactcatc caaataattt gaatctacgt
    10681 acaataacat atttgaagaa gcattacaat aagtttgaga taggtttttc tgatcataca
    10741 ataggtattt ctgctgctac agctgctgta gcgatgggag cggaaattat agaaaagcat
    10801 gtaacaattg atcggcatat gaaaggaaca gaccagcttg gctctttagg tccagatggg
    10861 gttaatcgta tgattcgaga tattcgcata gcagagtgtt ggcttggtac tgaagatctt
    10921 tatatagaaa aaggggtgga gaagtctaag ataaaacttg aacgttctat tgccactcga
    10981 aaatatattc cagcaggtag tattattcaa gagtcggaca ttcatttact gagtcctggt
    11041 gatggttata aatggataga taaaaaaaat gtaattggtc attttgctaa acaagatata
    11101 tcagcgaatg aaataatata tcctgatttt attgaataga tatattccta ctgcaacttg
    11161 tattacggta tagagtactg cctgctataa gctaagtagt gattaataaa taagggtaaa
    11221 atactaaaaa aatgaaagag ataaagctta tacttacaga tattgatggc gtttggactg
    11281 atggcggaat gttttatgat c
//
