LOCUS       gnlProkkaDAMGHGEM_2    11725 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DAMGHGEM_2.
ACCESSION   gnlProkkaDAMGHGEM_2
VERSION     gnlProkkaDAMGHGEM_2
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 10:37:15
            Original ID  :: gnl|Prokka|DAMGHGEM_2
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11725
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..1185
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 51.8;
                     E-value: 8.2e-16)"
                     /gene_kind="transport"
                     /locus_tag="ctg2_1"
                     /transl_table=11
                     /translation="MLNTIRELVNEAQGLTGDAFLNRAVLYRQREDLTSEVVQIDIRSI
                     MDGTSPNLALMKNDILYIPSIHDLEDRGNVTVHGEVAHPDSYPYADNMTLEDLIIQAGG
                     LKEAASTVRIDVSRRIKNPRSTADNDTIGQMYTFSLKDGFVIDGQPGFILQPYDEVYVR
                     RSPGYQAQQNVVIDGEILFGGNYAMTNREERLSDLVNKAGGPTSLAYLRGAKLTRVASA
                     GEKKRMGDVIRLMSRQLGEAMIDSLGIGVEDTFTVGIDLEKALTNPKGSADLVLREGDV
                     VFIPKNTNTVTINGAVMVPNTVSYMKGKDVDYYLNQAGGYSDNARKSKKFIVYMNGQVT
                     KVKGSGKKQIEPGCEIIVPGKAKKKGNIANILGYATSFSSLGMMIASIANLIKK"
     protocluster    1..11725
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[2411:6725]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2412..6725
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..11725
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11725
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             1200..2348
                     /locus_tag="ctg2_2"
                     /transl_table=11
                     /translation="MSEQRQDKNLLSEPHKTESDEIEIDLVDIFRKIIAIRKKLYKAVG
                     IGFIIGIIVAVSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVLFGKSLLASLRKELKNKEIEQDK"
     CDS             2412..3131
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 56.8; E-value:
                     3.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_3"
                     /sec_met_domain="NTP_transf_3 (E-value: 4.2e-17, bitscore:
                     52.9, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CGIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLIAPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             3152..4453
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 209;
                     E-value: 1.4e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_4"
                     /sec_met_domain="CTP_transf_like (E-value: 2.3e-13,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 9.7e-122, bitscore:
                     395.5, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.2e-63, bitscore:
                     204.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKTILENERALEVRELCMPIKEILELIPGTK"
     CDS             4470..5594
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_5"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.3e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.1e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             5604..6725
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg2_6_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg2_6"
                     /sec_met_domain="Aminotran_5 (E-value: 1.8e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        5694..6701
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg2_6_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg2_6_Aminotran_5.1"
                     /locus_tag="ctg2_6"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             6722..7195
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156:Chloramphenicol acetyltransferase (Score: 73.7;
                     E-value: 2.7e-22)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_7"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYSNIY
                     LGKNAEIRSGCYLIARDKIIIGENSTLAYGTTILTTADPNGPYNALAVLYPYKKAPVVI
                     GDNVWIGANVTILPGVTIGDYVVVAAGAVVTKDVPSGVLVAGVPAIVKKRFNK"
     CDS             7192..8637
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_8"
                     /sec_met_domain="Polysacc_synt (E-value: 9.6e-33, bitscore:
                     103.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEKTSLKNKAICGIFWSAVERFLSQGIQFVVTVIMARFLLPSDY
                     GMVGMLAIVLQLSQTLMDSGFTNALIRYKERTEIDYSTVFFFNILASLVIYFLIFFLAP
                     YISWFYKIGQLVEITRILSIVIVLNSFAIIPKTKLIIAVDFKTQSKVSFIAALVSGIIG
                     IWAAYLDFGVWALVGQTLVNGLLIVVLYAYFCRWKPLWIFSLKSFRLLFAFGSKLVLAN
                     ILNTLYKNLYAIVIGKKFSSVDLGFYTRAEQFAQFPSYNLSAIISRVTYPILSLVQNDN
                     DRLSALYRKYVRLSSAFIFPLMILLIVIAQPLVLLLLTEKWIGVVVLLQILCLDWMFDH
                     LSSINLNLLYVKGRSDLALRLEVIKKVLATGILLLSIPWGIVGMCWGRVMYSLIAVYLN
                     TYYTESLIKLSLIRQMRDILPSFFLALIMGGGTWYMILLLEGEIVQIVVGSVIALLLYG
                     TLLYCFSRSLFDEIWAVILKIKR"
     CDS             8637..9359
                     /locus_tag="ctg2_9"
                     /transl_table=11
                     /translation="MDKLSLIISKIRRNHWYRTYMRPIYLFVYGNRKLKNRNRIFLQYS
                     QELLTNFHQAMNEVGIPYWLEFGTLLGAVREHSFISHDFDLDVGLFKEDYSDIIREVLK
                     KYGFKRIRCITALDFIDAYEETYLYKGVTIDLFLFSREKNCDGVYCYDFVPVYSDIKRT
                     KKGDNAIRRIHFPRIDLIEYSFIGINTFVPENYEEHLCMHYGKDYMIPNPHWKDSDAQH
                     TDIFYGREIRIELFDKSK"
     CDS             9373..10386
                     /locus_tag="ctg2_10"
                     /transl_table=11
                     /translation="MFYLFFLLIVLFLLYIQSRKRQYSTVAGICVPIIIIFVVICRYRV
                     GYDYLTYYTLIENEEEAQILYLFSPLSIVWAEIALYFESPQMLFVLFGLPTFALLIFTL
                     KKYSKDYALSVTILICFFFFTSLSIIRQALALAICFYGYRFIVKRSLIKYILCILIAAL
                     FHPSAGVAIIIYWLPFLKFRLVVLLSIISIVAKPLFFYMLNILGVYTSYLDGKMDIEGG
                     KYTQLIYFLLFIICFVLGSKNIDKNKCNLFNVLLLSFVFVSFLGAHLGGRIAFYFNIYY
                     CLLIPKVVKGLDGQLREQVKLLSYFLCISYFLLYLFVPFIKGVPSYYIPYKFIFFK"
     CDS             10391..11350
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123:polyprenol-monophosphomannose synthase ppm1
                     (Score: 57.2; E-value: 3.2e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg2_11"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.2e-42,
                     bitscore: 135.7, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLISIIVPCYNSERYLSDCLLSILNQTYVNWEVICIDDGSQDNTL
                     SILNHYATLDERFKIISQSNAGVSVARNKALSQCQGEYICFVDSDDLIEPNFLITLLQL
                     ISHQADLAICGFTRSMVFCMDDAQGYIEMSGKRCIERIILDKSFNPQICCMLFRHNIIK
                     EKQLEFVIGCTRGEDREFILKYLVYSNKVCYTNNLLYHYRVNDQSAMAIFSIKSLTSIE
                     ASQRTVNYYKKVNYSVRGLEFEFSRTLWKFMILAILSGQNDLYQIIREKYDLKRQMEHL
                     YSHPGLSEKLTARLFVWNEALFKWVFSIIRYLYKKRWR"
ORIGIN
        1 aaactgaaca cgatccgcga acttgtcaat gaagcccagg gtctgaccgg tgacgctttc
       61 ctgaatcgtg ccgtccttta tcgccagcgt gaggacctga ccagtgaagt tgttcagata
      121 gacatcaggt ctatcatgga cggtacttcc ccgaacctcg ccctgatgaa gaatgacatc
      181 ctttacattc cgagcattca cgatctggaa gatcgtggca atgtcacagt tcacggtgaa
      241 gtcgcgcacc ctgattccta tccctacgct gataacatga cacttgagga tctgatcatc
      301 caggccggtg gcttgaaaga agccgcctct actgtccgca ttgatgtgtc gagacgaatc
      361 aagaatcccc gtagtaccgc ggataatgat actatcggtc agatgtatac cttctcttta
      421 aaggatggtt ttgtcatcga cggtcagccc ggttttatcc ttcagcctta tgacgaagtt
      481 tatgtccgtc gcagtccggg ttatcaggca caacagaatg tagtcattga tggtgaaata
      541 ttgtttggag gaaattatgc catgaccaac cgtgaggaac gtctttccga tctggtgaat
      601 aaagcgggtg gtcctaccag tcttgcctat ctccgtggtg cgaaattgac ccgtgtggca
      661 agtgcgggtg agaagaaacg tatgggtgat gtgattcgcc tgatgagcag gcaattgggt
      721 gaagccatga ttgactcttt gggtattggt gttgaggata cctttacggt aggcattgat
      781 ctggagaagg ctttgactaa tcctaagggt agtgccgacc ttgtcctacg tgaaggtgat
      841 gtggtcttta tacctaagaa tactaatact gtaactatca atggtgctgt tatggtcccc
      901 aatacggttt cttatatgaa gggaaaggat gtggattatt acctgaatca ggccggtggc
      961 tattctgata atgcaaggaa gagtaagaag ttcattgttt acatgaatgg tcaggtgacg
     1021 aaggttaagg gtagtggtaa gaaacagatt gagccggggt gtgagattat tgtgcctggt
     1081 aaggctaaga agaaagggaa catagctaat attttaggtt atgctacttc cttcagttct
     1141 ttgggtatga tgattgcttc tattgctaat cttataaaga aataatagaa tttactttta
     1201 tgtcagaaca acgacaggat aaaaacttgc tctctgaacc acacaagaca gaaagtgatg
     1261 agatagaaat tgatttggtc gatatctttc gcaagattat tgctattcgt aaaaaattat
     1321 acaaagccgt tggaattggt tttattattg gaataattgt agcggtaagt atccctaaac
     1381 agtatacagt aaaggttacc ctttctcctg aaatgggtaa tgcgaagggg agtaatggtt
     1441 tagccggact tgctgcctcg tttttaggag atggggctct aataggggaa agcacagatg
     1501 ccttgaacgc ttctctttca gcagatattg tttcttcaac tcctttttta ttggaacttt
     1561 tagaaatgga agtctccgtt tctaaaaagg atgataaaat gactttgggg tcttatctcg
     1621 atgaagagtc atctccttgg tgggattatc ttataggttt tccgggcata gtaataggag
     1681 gagttaaatc attattcgga gaagatacgg ttcctgccag tggagggcgg caaggaacta
     1741 tcgaattgac gaaagaagta aatgagaaga ttaattttct taaaaagaag attagtgcat
     1801 ccattgataa gaaaaccgcc ataacgagca ttacggtcac cttacaaaat ccgcagatca
     1861 ctgcggttat agcagattct gtcgttcata aattacagga atatattatt gggtatcgaa
     1921 cttcaaaagt aaaagaagac tgtgcgtatt tggaacggtt gtttaaagaa cgtcagcagg
     1981 aatattatgc tgctcaaaga aaatatgcgg attatgtaga cgcccatgat aatgtggttc
     2041 ttcaaagtgt acgtgctgag caggagcgtt tacagaacga catgagtttg gcttatcaga
     2101 tatatagtca ggttgctaat cagttgcagg tatccagagc caaagtacag gaggaaaagc
     2161 cagtctttgc agtagttgag cctgccgttg tacctttgaa accttcaggt atgggactca
     2221 aaatttatat tttattattt gtgttcctgt ccgtatctgg tactctcgtg tgggtgcttt
     2281 ttggcaaaag tctgctggct agcttgagaa aagaactgaa aaataaggag atagaacagg
     2341 ataaatgatg ctaaaacgtc gtttacaaca ttcttatatc aattaaattc acttactata
     2401 ttattaaacg aatgatacgt acagctatga taatggctgc gggcatggga acccgttttg
     2461 gccaatatac agaattgata cctaaagggt tcgtcaaagt gggaggtatt ccaatgatag
     2521 ttcgttctat tgatactttg ttatcatgtg gcattgagcg aattgtaatc ggtacaggat
     2581 ataaacaaga agtttatgaa gaattgaaga cagactatcc tatgcttgaa acctgtttta
     2641 gtcctcgtta tgctgaaaca aatagtatgt atactttata taatacgcgg gagattctgg
     2701 gcaatgatga ttttttattg ttagagtcag atttgatttt tgagaaacaa gcaataatga
     2761 gcttattgga gtgtcctgcg gcagatgcaa tgctaatagc tccagtgaca aagtttcaag
     2821 atcagtatta tgtggaacat gatgataatt ttcgcctttc ttcatgttct gtcaataaga
     2881 ataaactaaa cgctaaaggc gaattggtcg gcatccataa actatccggt tccttttaca
     2941 aaataatgtg tgctgattat gcgagtattg ttgatgaaca acccaatttg ggatatgagt
     3001 atgaattact acgaatatct tgttctcaat ctcctgttta tgtgcataaa gtagaagggc
     3061 tgaaatggta tgaaatcgat gacatatcag atttggaata tgcagagaaa tatattgttc
     3121 cgtattgtta attaaaataa tatatcaaat tatgagtaag acagtttata ttgggatgac
     3181 tgcggatatt atgcatccag gacttatccg cattattaat gaggctacta aatacggtga
     3241 tgttataatt ggtcttctta cagataaagc tattgcggag cataaacgcc ttccttatct
     3301 gacctatgaa caacgaaaag aggtagttca gaatattaaa ggcgtatgta aagttgttcc
     3361 tcaagaagaa tggagctatg ttgagaatct caaacgcatt aaacctgact atataattca
     3421 tggtgacgac tggaaaaccg ggcctttacg tgaagaacgt gtgcgcgtat ttgaagtgat
     3481 gaatgaacag ggaggaaagg ttatcgaaat tccatatact ttgggaatta attcatcttc
     3541 tttggataaa gatattaagg ctataggtac aacccccgat gtacgtttaa aatcacttcg
     3601 tcgtttgata aatgccaaac ccgtagttcg tattttggaa gctcatgatg gactatgtgg
     3661 cttgataatt gaaaatcagg aaatattaaa aggggataag agggaagtat ttgacggaat
     3721 gtggtctagt agccttacgg attcaaccag taaaggtaaa cctgatattg aggcggttga
     3781 tttaactacc cgattgcaag atttgaataa tattctggag tgtactacta aacctattat
     3841 ttttgatgga gatacaggtg gtaaaattga acatttcgta tttacagtac gcactttaga
     3901 acgtcatgga atctcagcta taataattga agataaagtt ggattaaaaa agaattcatt
     3961 gtttggtacg gatgttattc aaactcaaga tacaatcgaa ggtttctgta ataagatcaa
     4021 agcaggaaag gcatctcaga ttactgatga ttttatgatt atcgctcgta ttgagagcct
     4081 tatagcggga aagccggtaa gtgatgcttt agagagagct tttgcatatg tccaagcggg
     4141 agcggacggt attatgatac atagcaaaaa taagtcgggt gaagatataa aagaattttg
     4201 tttggcgttt cgaaaacagt atgctcatgt acctatcgtg gttgtgccta ctacatatga
     4261 tcatatttat gagtctgaat tgtgtgattg gggtgtgaat ataattattt atgctaatca
     4321 tatgcttcgt gccgcttatc ctgctatgat gaatgtcgca aagacaatat tagagaatga
     4381 acgtgcttta gaggtgcgcg aactgtgtat gcccataaag gaaatattgg aactgattcc
     4441 gggtactaaa taaaaagagg aatatcatta tgttaagcgt agaaaaagtt tatgaaacgt
     4501 ttctgagtca tgacgttgat ttttttacag gagttccaga ctcattacta aaaaatattt
     4561 gtgcctatat cacagaccat acttcacgtg agaaacatat catagctgct aatgaaggtg
     4621 cggctgtagg aattgcttca ggttattata tggcatcagg taaggttcct gtggtttata
     4681 tgcaaaattc cggcttgggt aatactgtta atcctctgct gtctcttgca gatgaacaag
     4741 tatacagttt tccaatgctt ttgatgattg gctggcgtgg tgaaccggga acaaaagatg
     4801 aacctcagca taaaaaacag ggtgaggtaa ctttagattt gttgaaagca atgcggattc
     4861 cttatataat tcttgattca aatgagaatg atgcatttat tcagctccat gatatcatac
     4921 aatcagcaaa aactaagaat attcctcatg caataattat tcggaaagat gtttttggca
     4981 aatataaact tcaaaaagag ttcggatgta attatccttt atctcgtgag gatgctttgc
     5041 aaatagttgt ggattatctg cctgaaaatt cagtggtcgt ttctactact ggcaagcttt
     5101 ctcgtgagtt atttgaatat cgagaaatga aagagcaagg tcatgaacat gattttctca
     5161 cggtaggctc tatgggacat agttcatcaa tctctttggg tattgctata gcaaagcaag
     5221 atagacctgt ttattgcttg gatggtgatg gagcatttat tatgcattta ggggcaatta
     5281 gtaacattgg cgatttatct cctaaaaact attatcatat tttgtttaac aatggtgctc
     5341 acgagtctgt aggaggacag cctactttag gatttagttt agatattccg gctattgtcc
     5401 gggggagcgg atataagcat acttatactg tttgtacaaa agttgaaatt gaagaagcaa
     5461 tgaagcagct tccaaagtta tgtggtcctg ttttgttgga aataaaggtt aaaatagatt
     5521 ctcgggagaa tttgggacgt cccacgacta ctcctataga gaataaggag cattttatgg
     5581 attttttaaa ataaatatat tcgatgaaaa tagaaagaaa aatattatta aatcctgggc
     5641 ctgccactac tactgacagt gtaaaaatgg cacaagttgt tccggatatt tgtcctcgcg
     5701 agaaagaatt cgcaggtatg atgaaacaac ttcgggacga tttggtcaga gttgctcatg
     5761 ggaatttgga aaaacatacc gctgtattat tttgtggctc aggaaccatc aatattgata
     5821 tatgtctaaa ttctcttctt cctgaagaca aaagggtgct tatagtgaat aatggggcat
     5881 atagtacccg tgctgtagaa gtgtgtcaat attatggttt gcctcatatt aatttggaat
     5941 tttccgttta cgaacgtcct gatttatcgg tggtggaaaa tgtgttgcaa gaaaatcctg
     6001 atatagctat ggtttatact actcatcacg agacgggtac aggaattctg aaccctattc
     6061 gcgagatggg cgctatagct cataaatatc aggctaaatt tgtcgtcgat actacttctt
     6121 ctttgggcat gattcctttt gatatagaga aagataatgt ggatttttgt atggcatctg
     6181 ctcaaaaagg acttcaagcg atgacaggtc tttcttttat tataggcaat gaggaacaga
     6241 ttaagttttc aaaaaaatat cccaagcgtt cttactattg taatctttat ttgcagtatg
     6301 agaattttga gagaacaggt gaaatgcatt ttactccacc ggtacaaact atttacgcca
     6361 ctcgtcaggc attaaatgaa tattttgaag tgggcgaaga agctaagttt gcccgtcaca
     6421 aaagagtttt tgaggctatt cattcaggta taaatgaaat tggtcttaaa agtgtaataa
     6481 agcgtgaatg gcagtcagga ctggttgtct cagttcaata cccagaagat cccaactggg
     6541 attttgagaa aatacatgat tattgttatg agcgtggatt tacgatttat ccaggtaaga
     6601 tatcaactga ggatactttt agaatctgtg ctttaggaga gatagaagta gatgatattg
     6661 agaacttctt taaagtacta aaagctgcat taaatcatta taacgtcaca ttaccgatgt
     6721 catgattgca gaaatattat tgaagattcg tcatttttat ttttcccttc gtggtataca
     6781 cttccatccg gaaagtgtta tttctggagt gcctattcgt agctttcgct tagtaggcaa
     6841 atatagcaat atctacttag gtaaaaatgc tgaaatacgt tcaggctgtt atctgattgc
     6901 tcgtgataaa atcattattg gagaaaactc aacactcgcc tatggaacga ctatattgac
     6961 aactgctgat cctaatggac cgtataatgc attagcagtt ctttatcctt ataaaaaggc
     7021 accggtagtt ataggagata atgtttggat tggggctaat gttaccatcc ttcctggagt
     7081 aactattggt gattacgttg tagtagcagc tggagctgtt gtaacaaaag atgtaccttc
     7141 aggagtattg gtagctggtg taccagctat tgtgaaaaaa cgttttaata aatgaaagaa
     7201 aaaacttctt taaagaacaa agccatatgt ggaatctttt ggagtgcagt tgaacgattt
     7261 ttatcacagg ggatacagtt tgtagttaca gtcattatgg cgcgttttct attgccatct
     7321 gattatggaa tggtaggaat gttagcaata gttcttcaat tatctcaaac gttaatggat
     7381 agtggtttta ctaatgccct tattcgttat aaggaacgta ctgaaattga ttattcaaca
     7441 gttttctttt ttaatatatt agcatcatta gttatttatt ttctaatttt ttttctagct
     7501 ccttatatat cgtggtttta taaaataggt caattagttg agattactag aattttatct
     7561 attgttattg ttttaaattc ctttgcgatt attcctaaaa ctaaattaat aatagctgta
     7621 gattttaaaa ctcaatcaaa agtctcattt attgcagctt tggtttcagg tattattggc
     7681 atttgggctg catatttaga ttttggagtt tgggctttag ttggacaaac tttagtaaac
     7741 ggattgttga ttgtagtttt gtatgcatat ttttgtagat ggaaaccatt gtggatattt
     7801 tcattgaaat cgtttcgttt attatttgct tttgggtcaa aattagtatt agctaatatt
     7861 cttaatactt tatataaaaa tctgtatgct atagttatag gaaagaagtt ttcgtcggtt
     7921 gatttaggat tttatactcg tgcggaacaa tttgctcagt ttccttcata taatttgagt
     7981 gcaataattt ctagagtgac ataccccata ttgagccttg tgcaaaatga taatgataga
     8041 ttatctgctt tatataggaa atatgtccgt ttatcttctg cttttatctt tccattgatg
     8101 attttgttaa ttgtcatagc tcagccactg gtattattgc ttttgacaga aaaatggata
     8161 ggagtagttg tattgcttca aatattgtgt ttagattgga tgtttgatca tttgagtagt
     8221 ataaatttga atttactata tgtaaaggga cgttcagact tggctttacg tttagaagtt
     8281 ataaaaaaag tgttagcgac ggggatcctt cttctatcta ttccttgggg gattgtaggt
     8341 atgtgttggg ggcgtgttat gtattcattg attgctgtgt atttgaatac ttattataca
     8401 gaatcattga ttaaattaag tcttattaga cagatgagag atatactacc aagctttttt
     8461 ttagcattaa taatgggagg aggtacttgg tatatgattt tattgttaga gggtgaaatt
     8521 gttcaaattg tagtaggaag tgttattgct ttattgctat atggaacgtt gttgtattgc
     8581 ttttctcgat ccttgtttga tgaaatatgg gcggttatat taaaaataaa aaggtaatgg
     8641 ataaactgag tttgattatt agtaaaatac gacggaatca ttggtataga acctatatgc
     8701 gtcctatata tttatttgtt tatggcaata gaaaattgaa gaatagaaat agaatatttt
     8761 tgcagtattc acaagagctg ctaactaact ttcatcaagc aatgaatgaa gtgggaattc
     8821 cttattggtt agaatttgga actcttttag gtgctgttag agaacacagt tttataagtc
     8881 atgattttga tcttgatgtg ggccttttta aggaagatta ttcagatata ataagagagg
     8941 tcttaaaaaa atatggtttc aaaagaataa ggtgtataac cgcccttgat tttattgatg
     9001 cttatgagga aacttatctt tataaaggtg tgacaattga tcttttcctt ttttcaagag
     9061 agaaaaattg tgatggggtc tattgttatg attttgttcc agtatattca gatataaaga
     9121 gaactaaaaa aggtgataat gcaatccgga gaattcattt tcctagaatt gatttgattg
     9181 aatattcatt tattggaatt aatacttttg ttcctgaaaa ttatgaggaa catctttgta
     9241 tgcattatgg taaagactat atgattccaa atcctcattg gaaagattca gatgcgcaac
     9301 atactgatat cttttatggt agagagatta gaattgaatt gtttgataaa agtaaataat
     9361 agtagataat acatgttcta tctatttttt ttactaattg tgctattttt gttatatata
     9421 caaagtagga aaagacaata ttctactgta gcgggaattt gtgttcctat tattataatt
     9481 tttgttgtaa tttgtcgtta tagagtgggg tatgactatt taacgtatta tacattaatt
     9541 gaaaatgaag aagaggcaca gattttatac ttattttctc ctttaagcat tgtttgggca
     9601 gagattgctt tatattttga atctccacag atgttatttg ttctttttgg gcttccaaca
     9661 tttgctcttc taatatttac tttaaaaaaa tattcaaaag attatgcgtt atcagtaact
     9721 attttaattt gtttcttctt ttttacatca ctcagtatta ttcgacaagc tttggctttg
     9781 gctatttgtt tttatggtta tcgttttata gtaaaacgtt cactaattaa atatatatta
     9841 tgtatattga ttgcagcttt attccatcct tctgcaggag tagcgattat tatatattgg
     9901 ttgccatttc taaagtttag attagttgta ttattatcta taatatcaat agtagccaaa
     9961 cctttatttt tttatatgct aaatatatta ggggtgtata cctcttatct tgatggcaag
    10021 atggatattg aaggtgggaa atatactcaa ttaatatact ttttgttgtt tattatttgt
    10081 tttgttttgg gaagtaaaaa catagataaa aacaagtgta atttatttaa tgttttattg
    10141 ttaagttttg ttttcgtatc ttttttagga gctcatttag gcgggagaat agcgttttat
    10201 tttaatatat attattgttt gttgattcct aaagtggtta aaggattgga tgggcaacta
    10261 agagagcaag tgaagcttct ttcttatttt ctatgtattt cttatttctt attgtaccta
    10321 ttcgttccat tcataaaagg tgtaccctca tattatatcc catataagtt tatatttttc
    10381 aaatagtaaa atgttgatat ctataattgt cccttgttat aattctgaaa gatatttgtc
    10441 tgattgttta ttgtctatat tgaatcaaac ctatgttaat tgggaggtga tttgtataga
    10501 tgatggaagt caagataata cattatctat tttaaatcat tacgctacat tggatgagcg
    10561 ttttaaaatt atttctcagt ctaatgcagg agtgtctgtc gcaagaaata aggctctatc
    10621 ccagtgtcaa ggagagtata tttgctttgt tgatagtgat gacctgatag aacctaattt
    10681 tttgataaca cttttacagc ttataagtca tcaggctgat ttggcaatct gtggttttac
    10741 tcgttctatg gttttctgta tggatgatgc tcaaggatat atagaaatga gtggtaaacg
    10801 ttgtatagaa agaattattc tagataaaag tttcaatcct cagatttgtt gtatgttatt
    10861 tcgacataat attataaaag agaaacaatt agaatttgtg atagggtgta ctcgtggtga
    10921 agatcgtgaa tttatattga aatatttagt ttattctaat aaggtttgtt atacaaacaa
    10981 tcttctttat cactatcgtg taaatgatca gtcagccatg gcaatctttt ctattaaaag
    11041 tttgacaagt atagaagctt cacaacgcac ggtcaactac tataaaaaag tgaattattc
    11101 tgttagaggg cttgaatttg aattttcacg tacattgtgg aaattcatga ttttagctat
    11161 tttgtctggg caaaatgatt tatatcaaat cattcgagaa aagtatgatc taaaaagaca
    11221 aatggaacat ctttattctc atccaggact atccgaaaaa cttacagcga gattgtttgt
    11281 ttggaatgag gcacttttta aatgggtatt ttctattatt agatatctat ataaaaaaag
    11341 atggagatga ataaacgaaa tagattatct gaacaagaaa taaaaaaagt agaacttgac
    11401 gctttattgt atattcggaa aatttgtcag caatatcatc ttcgctatta tttagcttgg
    11461 ggtactttgt tgggagccgt taggcataaa ggatttattc cttgggatga tgatattgat
    11521 ataatgatgc cacgttcaga ttatgagcga ttattggagt tagttccttc cttgagacat
    11581 agttattata aaatcttaag taatccaaag aatgaggatt attattatac tcatgcaaaa
    11641 atgatagata ctcgtacttt gtgtgtggaa aatgatttgc aaactattca aaatatgggg
    11701 atttgggttg atattttccc cttag
//
