LOCUS       c00088_gnlPro..        14253 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DAMGHGEM_88.
ACCESSION   c00088_gnlPro..
VERSION     c00088_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 18:14:00
            Original ID  :: gnl|Prokka|DAMGHGEM_88
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 40448
            Orig. end    :: 54701
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14253
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[50448:54477](-)"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      complement(10001..14029)
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..14253
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14253
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             complement(245..1402)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg88_43"
                     /sec_met_domain="Aminotran_1_2 (E-value: 5.6e-48, bitscore:
                     155.6, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYNFDEIVPRRGTNSYKWDSAGDADVLPMWVADMDFRTAPSVVE
                     ALKRRVEHGIFGYVRVPDAYYEAITRWFAGRHGWQIEKEWIIYTTGVVPALSAVIKALT
                     TPGDKVIVQTPVYNCFFSSIRNNGCEVVANPLIYMNGTYQIDFIDLERKAADPSVKVLL
                     LCNPHNPAGRVWTKQELTRLGEICLRNNIWVVADEIHCELVFPGHTYIPFASVSEEFLM
                     HSVTCTSPSKAFNLAGLQIANIVSADTDIRMQIDKAININEVCDVNPFGVEALIAAYND
                     GEEWLEELNQYLFANYHYLRAYFDEYLPEFPVLPLEGTYLVWVDCSALKQSSEDIVKTL
                     LEKEKLWVNEGNLYGEAGERFIRINIACPRQRLIEGLNRLRRALK"
     CDS             complement(1408..2271)
                     /locus_tag="ctg88_44"
                     /transl_table=11
                     /translation="MKQIKNTHYEGERPLFASHGLYLEEVTIHAGESALKECSDIEAVN
                     CRFEGKYPFWHNDGFVVKNCLFTEGARAALWYSRNLKMKDTLVEAPKMFREMDGVELEN
                     VQLPNALETLWYCRNVELNNVKIDKGDYLFIHGEDIRIKNFVLNGNYSFQYCKNVEIRH
                     AEIHSKDAFWNTENVTVYDSVLDGEYLGWHSKNLRLVNCKISGTQPLCYAHDLIMENCT
                     MADDADLAFEHSSVKATIKGPVHSVKNPRTGNIVAESFGTIILDENLKAPGNCELKLWD
                     GLTCFD"
     CDS             complement(2321..3352)
                     /locus_tag="ctg88_45"
                     /transl_table=11
                     /translation="MKRILLLTVVFIMMLGTSFSFAQADADNFYKSDWVKVEKVSFSNQ
                     YKMKVAGNLFLPKTMKEGEKYPAIIVGHPMGAVKEQSANLYATKMAERGFVTLSIDLSF
                     WGGSEGEPRNAVLPEVYAEDFSAAVDFLGTRPFIDRNNIGVIGICGSGSFAISAAKIDP
                     RLKAIATISMYNMGTASRNGLKHALTLEQRKQIMAEAAEQRYAEFLGGETKYTGGTVHE
                     ITENSGPIEREFYEFYRTQRGEFTPEGATLTTTTHPTLSSNVKFMNFYPFEDIETISPR
                     PMLFITGENAHSREFSEDAYRLAADPKELYIVPGAGHVDLYDRVGLIPFDKLESFFKEY
                     LKK"
     CDS             complement(3483..4688)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1058:Major
                     facilitator family (Score: 103.7; E-value: 3.3e-32)"
                     /gene_kind="transport"
                     /locus_tag="ctg88_46"
                     /sec_met_domain="MFS_1 (E-value: 2.8e-32, bitscore: 103.7,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQKNQSKLHSGGLLVFILTVGVFGIINTEMGVVGILPLIAETFD
                     VSVPQAGWTVSIFALVVAASAPVTPLLFSGVNRKKVMLLALGLFTLSNIISMLTTNFTV
                     LLVARILPAFLHPVYVSMAFTVAAASVSKEKAPKAVSRVFVGVSAGMVLGVPVTSFIAS
                     EVSFSMSMLFFTVVNALVLIATILFIPSMPVKEKVSYGAQLSVLKRTVMWNSIIAVTLI
                     NGAMFGFFSYMSDYLKTVTEVSYSVISVVLLVYGLANIVGNVLAGKLLSINARRSIIIM
                     PFALLVSYICLFITGEWITAMVIIILILGVLAGIASNNMQYMIAEAAPEAPDFANGMFL
                     TSANLGTTIGTAVCGAFITEMGTRYSVFGALFFLIASIVFVYLRVRVAHSQKQVKMNMA
                     TE"
     CDS             complement(4703..5251)
                     /locus_tag="ctg88_47"
                     /transl_table=11
                     /translation="MKKVLVIMSAGTKLGNTDRLTDAYIKGLVERGHSVTKVYLGSMRI
                     EGCRGCGVCQRLAHQCAVRDGMQDIYPLFAECDTVVMASPLYFWTITSQLKAFIDRLYA
                     ISADDKYPQKDTVLLMTAGDDNENTFDQPKQYFRLLSQALGWNEVGIYCAGGCTGCEKL
                     ARQIDKVHLENVYKMGLEL"
     CDS             5821..7578
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Transketolase_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Transket_pyr"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Transketolase_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg88_48"
                     /sec_met_domain="Transketolase_C (E-value: 1.8e-16,
                     bitscore: 52.0, seeds: 80, tool: rule-based-clusters)"
                     /sec_met_domain="Transket_pyr (E-value: 9.4e-18, bitscore:
                     56.2, seeds: 81, tool: rule-based-clusters)"
                     /sec_met_domain="Transketolase_N (E-value: 5.5e-07,
                     bitscore: 20.5, seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYLENIYSPADVKKLSFQELNDLSHEIRASLLQKLSAHGGHFGPN
                     FGMVEATIALHYVFNSPKDKIVYDVSHQSYVHKMLTGRKDAFLHPAEYDHVSGYSEPQE
                     SEHDFFVIGHTSTSVSLASGLAKGRDLTGGNENIIAVIGDGSLSGGEAFEGLDYVAELG
                     TNMIIIVNDNQMSIAENHGGLYKNLKDLRDSNGQCECNFFKAMGLDYMYVNDGNCVEAL
                     IEAFSKVKDIQHPIVVHINTLKGKGYEPAEQDKETYHWRTPFDLETGKSKMNDDAEDYS
                     EVTAQYLLKKMKEDKRVVTITSGTPAVLGFTPDRRQEAGKQFVDVGIAEEHAVALASGI
                     AANGGKPVYGVYSTFIQRSYDQLSQDLCINNNPAVLLVFWGTLSGMNDVTHLCFFDIPL
                     ISNIPNMVYLAPTCKEEYLAMLEWSIHQNEHPVAIRVPATDVISCGEPVESDYSNLNRY
                     KVAHRGSKVAILALGSFFGLGQSVLSLLKEKANIDATLINPRYITGVDSELMDELKADH
                     ELVITLEDGVLDGGFGEKIARYYGATDMKVLNYGAKKEFVDRYDIQELLRANHLTDEQI
                     VEDILSLIG"
     CDS             complement(7665..8555)
                     /locus_tag="ctg88_49"
                     /transl_table=11
                     /translation="MVKSRIFDNRQLLKEHPEIPHYKEEVVCFMSEYKDRSYPENERYF
                     NRELYMILVLEGRSEILLNGEFIVIEPDMLLVHGANYLTDHLYSSPDIKFITLSISESM
                     RTDDSYLTQITAILLATMRQNKQYTIQLTAYEAQIIRNELEVLMRLLNIKHQFLFRRIQ
                     AACNALFLDIADFLSRKTIIKKEVSRKDHVLQEFHALVTRNFREEHFVSFYADKLAISE
                     QYLARIVRAGTGKSVNTIINELLIMEARTLLSSTKSTVGDIASRLGFSDAAGFCKFFKR
                     NMGQTPLNYRKGLWI"
     CDS             8712..9383
                     /locus_tag="ctg88_50"
                     /transl_table=11
                     /translation="MGMKDVFKRYLVFVIGLYFLAAGIVLIVRSALGTTPISSINYVLS
                     LNSPLSLGTCTFLINMLLILGQFWVIRKNRTRQDTIEILLQLPFSFIFSAFIDFNMALT
                     SNLHPDNYGMSIALLLTGCMIQSIGVVLELKPKVAMMSAEAFVKYASRRYNKEFGKFKV
                     CFDVTLVTLAVILSLLLSQCIEGVREGSLIAACITGYIVSFLNQKIMTRKTLYKLLPVL
                     K"
     CDS             complement(9391..10014)
                     /locus_tag="ctg88_51"
                     /transl_table=11
                     /translation="MTTTNNNEDLEKKIIEAAKELFIENGFAETSMSDIAAKVGINRPA
                     LHYYFRTKDKMFQAVFGNIILSFIPKIHDIIIQQDKPVSESIGEIVDAYYKVFTENPCL
                     PLFMVREMHRDMNHLSDTIKELRLEQYLHKIMDVLQEEMNDGRLKTVPLPFVFYTFYSA
                     LTVPFLTKNLSASFFLEKDDSFEDILVQWKPYIVRQMETLLVVS"
     CDS             complement(10001..14029)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg88_52"
                     /sec_met_domain="HGD-D (E-value: 3.2e-28, bitscore: 91.1,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 5.9e-35, bitscore:
                     112.7, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGISEKCSLPFVQEVVAAAKAIQKDYSHVTSMIDIGGEDAKVVFF
                     KDAEATDLRMNGNCAGGTGAFIDQMAIILGVNIDELNQLAMNATQVYPIASRCGVFCKT
                     DIQNLIAKNVSRENIAASIFRAVAVQTVVTLAHGCDITTPVLFCGGPLTFIPALRKAFI
                     DYLSLDEKEIILPANGTLLPALGAALFHLDKEDYCKLSHLIDKIDTTLNGNGNLASTGL
                     EPVFASNEEYEAWKERISRHKMISSGLKAGTQDVFIGIDSGSTTTKIVVLDEDSRLLYS
                     YYNINGGNPIKAVEEGLNQLNDECLKQNAVLNIKGSCSTGYGEDLIRSAFQLHSGIIET
                     IAHYMAAHYLNKDVSFILDIGGQDMKVIFVNNGVIDRMEINEACSSGCGSFLETFAKSL
                     GYSAQEFSLAACHSEAPCDLGTRCTVFMNSKVKQVLREGATINDIAAGLAYSVVKNCLY
                     KVLKLKDISVLGKDIVVQGGTMRNDAVVRAIELLSGAEVARCDTPELMGAFGCALYAMK
                     HQGESVSLDEIINKAQYSARSLYCKSCDNRCLVIRYEFESGKSYYSGNRCEKVFTNGES
                     SNRKGLNVYRQKEELLFHRSAEIAAPEQIIGIPRCLNMYEEYPFWHTLFTSCGIQVCLS
                     DPSNFRKYEHNARMVMSDNICFPAKLVHSHVQDLIEKKVDRIFMPFVIFERKGMEQNSY
                     NCPIVTGYSEVIKSVQSEGISVDSPAITFKDRNLLFKQCREYLSGLSVDDRTIQQAFQK
                     AESEQHSFINTLVDYNKNILQQTGKGETLTVMLAGRPYHTDSLIQHKVSDMLSDMGVNV
                     ITDDLVRQMDIPTGDAHFVAQWAYTNRILKAAKWCATQGKNIQFVEMTSFGCGPDAFLV
                     DEVRDLLMRHNKSLTLLKLDDINNIGSMKLRVRSMIESLKLANADGTEGDVKDFTTVPV
                     YDKSYRDRKILVPYFTPFISPLIPAIMKVAGYDAENLPLSDNDSSEWGLKYANNEVCYP
                     ATLIVGDIIKALKSGKYDISKIAVAITQTGGQCRASNYISLIKKALVDAGYTDIPVISI
                     SVGSDIDNDQPAFKVNWMKVVPITFHAVLYSDCIAKFYYASVVREKEAGASAKLRDKYL
                     QLAPEVILRRNIKGLNSLLQSAITEFNEVCRAVDTPKVGIVGEIFLKFNPFAQKEIIDW
                     LIGRKIEVVPPILADFFMQGFVNRKVNTDSYIKNRQLPEFIYDWIYKFVKKQIDKINET
                     ASKFRYFAPFNDIFEEAEGAKSVISLNAQFGEGWLLPAEIVSYARQGVNNVVSLQPFGC
                     IANHIVSRGVEKRIKSFYPDINLLSLDFDSGVSDVNITNRMLLFIDNLKNATMNYDNN"
ORIGIN
        1 tccaagaagt atcagccctg cagtcgtaaa ccgcagtgct ccgagcagaa aaggtgaaaa
       61 atctttcaaa gccaccccta taaaaaaata ggtggagccc cagactacat aaatgaggaa
      121 ataagcgatg ataacacccg gcaaattcct ctttgaggga ttctgacttt tcatatcact
      181 tctttttatt tgtatttacg gggagtgaga aggggaacct attaataaac tgacaattat
      241 tttattattt caatgcccgc ctcaatctgt ttaatccttc tatcaaccgc tgtcgcggac
      301 acgcgatgtt aatacggata aacctttcgc cagcctctcc atacagattg ccttcgttta
      361 cccaaagctt ttccttctcc aacagagttt tcactatatc ctccgacgat tgtttcaaag
      421 ccgagcaatc tacccatact aagtaggtac cttccaatgg cagcaccgga aattcgggaa
      481 gatattcatc aaagtaagcc cttaaataat ggtagttggc aaacaggtat tggttaagtt
      541 cttccagcca ttcttccccg tcattgtaag cagctatcaa ggcttcaacg ccaaacggat
      601 ttacatcaca gacttcattg atattgattg ccttgtctat ttgcattcgt atatccgtat
      661 cagcagaaac aatattggca atctgaagcc ccgccaaatt aaaggcttta ctaggcgagg
      721 tgcaagtaac ggaatgcatc aaaaactctt ctgagacaga tgcaaaaggg atataggtgt
      781 gtcccggaaa gacaagttcg caatgaatct cgtccgctac tacccatata ttattccgaa
      841 gacagatttc tcccaagcga gtcagttcct gctttgtcca gactcttccg gcaggattgt
      901 gcggattgca taatagcagg acttttacac tcgggtcagc cgccttccgt tccaaatcga
      961 taaagtctat ctgatacgtt ccgttcatgt aaatcaatgg atttgcaaca acctcgcatc
     1021 cgttattgcg gatggaggag aaaaagcagt tatagacagg tgtctgcacg attactttat
     1081 caccgggagt tgtcagcgcc ttgatgacag ctgacagggc cggtactact ccggtcgtat
     1141 aaataatcca ttctttttca atctgccagc catgacgtcc ggcaaaccat cttgttatcg
     1201 cctcatagta agcatcgggc acacgcacat atccgaagat accatgttcc acccgccttt
     1261 tcagtgcttc caccacagag ggagctgtac ggaaatccat atcagctacc cacattggta
     1321 atacatccgc atctccggca gaatcccatt tataggaatt tgtacctctg cgtggaacaa
     1381 tttcatcgaa gttgtacttc atatatttca atcaaaacaa gtcagtccgt cccaaagttt
     1441 caattcgcag tttcccggag ctttgaggtt ctcgtccagg atgattgtcc cgaaactttc
     1501 ggcaacaatg tttcccgtac ggggattctt cacgctgtga accgggcctt taatcgttgc
     1561 cttcacacta ctgtgttcga aagcaagatc ggcatcatcc gccattgtgc agttttccat
     1621 tatcaggtcg tgtgcataac aaagtggctg cgtgcccgag atcttacaat tcactaaacg
     1681 taagttttta gaatgccagc ccaaatattc accgtccaat acagaatcat atacagtcac
     1741 attctccgta ttccaaaatg catccttcga atggatttca gcatggcgga tttctacgtt
     1801 cttgcaatat tggaaggagt aattgccatt caatacaaaa ttcttgatgc ggatgtcttc
     1861 cccatgtata aagagatagt ctcctttatc tatcttcaca ttgttcagtt ctacattccg
     1921 gcaataccag agtgtttcca aagcattggg caactgtaca ttttcgagtt cgactccgtc
     1981 catttcgcga aacatcttcg gtgcttccac taatgtatcc ttcatcttca gatttctgga
     2041 ataccagagt gcggcacgtg ctccttcggt aaaaaggcaa tttttaacta caaaaccgtc
     2101 attatgccaa aacggatatt ttccctcgaa acgacagttt accgcttcta tatcactgca
     2161 ctctttcagt gccgattcac cggcatgaat ggttacttct tccaaataaa gcccgtggga
     2221 tgcgaacaaa ggacgttcgc cttcgtaatg tgtattttta atttgtttca tgattcgatt
     2281 gtcttttatt taaatagtta tctgtttttc ctgttcatac ttatttcttc agatattcct
     2341 taaaaaagga ttccaattta tcaaatggta taagccccac acggtcgtaa aggtctacat
     2401 gacctgcacc gggtacaatg tacagttctt tggggtcggc agccagtcgg taggcatctt
     2461 cactaaattc gcgtgagtgg gcattttctc cggttataaa aagcatagga cggggcgaaa
     2521 tagtctcaat atcttcgaaa ggatagaaat tcatgaattt cacgttgctt gaaagtgtag
     2581 ggtgtgtggt agttgtcagg gttgctcctt cgggagtaaa ctctcccctc tgagtgcggt
     2641 agaactcata aaattcgcgt tctatcggac cagagttttc tgttatttca tgtacagtgc
     2701 cgccagtata tttagtttct ccgcccagaa attccgcata gcgctgttct gctgcctcag
     2761 ccatgatttg tttccgttgt tccagagtca gcgcatgttt cagtccgttg cggctggctg
     2821 tacccatgtt gtacatgctg atggttgcaa tcgctttcag acgagggtct atcttggccg
     2881 cactgatagc gaaacttccg ctgccacaaa ttccgattac acctatatta tttcggtcga
     2941 tgaacggacg tgtacccaaa aaatctactg cggcactgaa atcctccgca tatacctccg
     3001 gcaaaacagc attgcgcggc tcaccttcac ttccacccca gaaggataaa tcaatggaca
     3061 gcgtaacgaa accacgttcc gccattttag tagcatacag attcgcactc tgttccttga
     3121 ccgctcccat cgggtgtccg acaatgatgg caggatattt ctctccctct ttcatggtct
     3181 tcggcaaaaa caggttgccg gctactttca ttttatactg gttagaaaaa gaaacctttt
     3241 ctacctttac ccaatcactt ttataaaagt tatccgcatc agcctgtgcg aaagaaaaac
     3301 tggttccaag catcataata aatacaacgg ttaataataa tattcgtttc atatctctta
     3361 catttaatta ttaatgaatt gattgtctac tttctacatt acaaaaatac ggtgaaataa
     3421 agagagtgtt tgtagatgaa ttactgacat tattacccca attacggatt atatattttt
     3481 catcattccg ttgccatatt cattttaact tgtttctgtg aatgagctac acgaactctc
     3541 aaataaacaa acacaatact ggcaatcagg aaaaacaatg caccgaatac agaatagcgt
     3601 gtgcccattt ccgtgatgaa agctccgcat acggctgtac cgatcgttgt ccccaaattg
     3661 gcagaagtca gaaacattcc gttggcaaag tcgggagctt cgggagcagc ttccgcgatc
     3721 atatattgca tattattact tgctatacct gccaatacac ctaaaattaa aataatgatt
     3781 accatagctg taatccactc tcctgttata aagagacata tataggaaac cagcaatgca
     3841 aaaggcatga taataattga acgccgcgca tttatcgata atagttttcc ggcaagtacg
     3901 ttacctacaa tattagccag accatagacc aataatacaa cactaatcac actgtatgat
     3961 acttccgtca ctgttttcag atagtccgac atataactaa agaagccgaa catagctcca
     4021 ttaatcaagg tgacggcaat gatagagttc cacatcaccg ttctcttcaa tacgctgagt
     4081 tgtgcaccat aagatacttt ctcctttacc ggcatggagg ggataaacaa aatcgtagct
     4141 ataagaacca aggcatttac aactgtgaaa aacagcattg acatagagaa tgagacctca
     4201 ctagctataa agctggtcac cggaacaccc agcaccatac cggcagacac accgacaaaa
     4261 acccttgaaa cagcctttgg agccttttcc ttgctgactg atgccgccgc tactgtaaaa
     4321 gccatcgaaa catataccgg atgaagaaag gcgggaagta tccgcgcaac caatagtact
     4381 gtaaaattgg tagtgagcat ggatataata ttactcagtg taaacaatcc caatgccagc
     4441 aacatgactt tcttccggtt tactcccgaa aacaataacg gagtgacagg agccgatgca
     4501 gctaccacca gtgcaaagat actcaccgtc caacctgcct gcggcaccga gacatcaaaa
     4561 gtttcggcta ttagaggcag gatacccact acccccattt cggtatttat aataccaaac
     4621 acaccgaccg tgaggataaa tacgagcaaa ccgcccgaat gaagttttga ttgattcttt
     4681 tgttccatat taaatctgct atttacaatt ccaatcccat tttatagaca ttttcaagat
     4741 gtaccttatc tatttgccgt gccagctttt cgcatccggt acaaccgccg gcacaatata
     4801 ttccgacttc attccaaccc aatgcctggc tcagaagccg gaaatactgc ttgggttggt
     4861 caaaggtgtt ctcattatcg tcaccggctg tcatcagtaa taccgtatct ttctgcggat
     4921 acttgtcgtc ggcagagatg gcgtaaagcc tgtctataaa agcttttaac tgtgacgtga
     4981 ttgtccagaa atacaaaggt gaagccatga ccactgtgtc acattctgca aacaaaggat
     5041 atatatcctg cataccatcc cgaactgcac attgatgagc gagccgctgg catacgccgc
     5101 aacctctgca gccttctatc cgcatactgc ccagatatac tttggttacc gaatgtcccc
     5161 gttccacgag tcctttaata taagcgtcgg tcaaccggtc tgtattaccg agttttgtcc
     5221 ccgcgctcat tataacaagt acctttttca tatttccaca atgtattttt tctattgtcc
     5281 ggggaaacgg accatctgcg ggttctttat cattcagaaa ccgacaaatc cccgccccgc
     5341 ctaacagtaa acttccggtt gctatcatcg tacttttcaa gaagcctttt ctatccatat
     5401 tctttatata attagttcca tatactcaag gtgattcgac agtacaaagg tcggaagaat
     5461 taagtgaagg gattgtagac agattacggg tataattacc ccaattacag attataggtt
     5521 tccatctttc tatcacacaa gaacagatat tattatagca tcctattttg ctattatata
     5581 atgattacgc gtgcgcgata cctattacaa cagtatattc aggtaaaaag aatcaagctt
     5641 gcaaaagagc atatggttga tatagaggaa gtcgtatttt atgttttatc aagcccattt
     5701 ttagcggaac tgtaatatag gtaaaagaat ccgtaattca tatacaaaca gatttcaaat
     5761 ccgtcagtat ctttgcagtg aaataaaaat ataggtataa acataaaaaa acaaattgat
     5821 atgtatttag aaaatattta ctctcccgca gacgtaaaga agttatcgtt tcaggaactg
     5881 aatgatttaa gtcatgaaat ccgtgcatca ctcttacaaa aactgagtgc acacggtggg
     5941 cacttcggcc ctaacttcgg aatggtagaa gcaaccattg ccctgcacta tgttttcaat
     6001 tcgccgaaag ataaaattgt atatgatgtg tcacatcaga gttatgtaca taagatgcta
     6061 accggacgca aagatgcttt tctccatcct gctgaatatg atcatgtatc cggctactca
     6121 gaaccacagg aaagtgaaca tgatttcttt gtgatcggtc atacttctac ttctgtcagc
     6181 ttggcaagcg gactggcaaa aggacgtgac ctgacaggcg gcaacgaaaa tatcatcgct
     6241 gtaataggcg acggttcact aagcggaggc gaagccttcg agggactgga ctacgtagca
     6301 gagctcggta ctaacatgat tattattgtc aatgacaatc agatgtccat cgccgaaaat
     6361 cacggaggct tatacaaaaa tctgaaagat ttgcgcgaca gtaacggtca atgtgaatgc
     6421 aatttcttca aagcgatggg gctggactat atgtacgtga atgacggcaa ctgtgtggaa
     6481 gcactgatcg aggctttctc caaagttaaa gatatacagc atccgatagt agtccacatc
     6541 aatacattaa aaggcaaagg ttacgaacct gcagaacagg acaaggagac ctatcactgg
     6601 cgtactccgt ttgatctaga aaccggaaaa tcaaaaatga acgacgacgc agaagattat
     6661 agtgaagtaa ccgctcaata tctgctgaaa aagatgaaag aagacaagcg tgtagttacc
     6721 attacttcgg gcacccccgc tgttttgggc ttcactcccg accgtcgtca ggaagcaggc
     6781 aagcagtttg tagatgtcgg tattgccgaa gagcatgcag tggcacttgc ttccggtatc
     6841 gcagccaatg gcggaaaacc ggtttacgga gtgtacagca cctttataca acgttcttac
     6901 gaccagctat cgcaagacct ctgcatcaat aataatccgg cagttctgtt ggtattctgg
     6961 gggacgttat ccggtatgaa tgatgtaact cacctctgtt tcttcgatat tccacttatc
     7021 agcaatatcc ccaatatggt ctatctggca cctacctgta aggaggaata tctcgccatg
     7081 ctggaatgga gcatccacca aaatgagcat ccggtagcta tccgtgtacc tgccacagat
     7141 gtaatcagtt gcggtgaacc ggtggaatcc gactatagca atctcaatcg ttataaagtc
     7201 gcccaccgtg gctccaaagt agcaatcctt gcattaggct ccttcttcgg attagggcaa
     7261 tcggttctgt cactgctgaa agaaaaagcc aacattgatg ccacccttat caatccccgc
     7321 tacatcacag gtgtggacag cgaactgatg gacgaactga aagccgacca cgaattagtg
     7381 attacactgg aagacggagt tctggatggt ggtttcggtg aaaagattgc ccgttactat
     7441 ggcgctacag atatgaaagt gctcaactac ggagctaaaa aagaatttgt agaccgttat
     7501 gatatacagg aactgcttcg tgccaaccat ctgacggatg aacagatcgt agaagatatc
     7561 ctatcactca ttggctgata agtcaaaacc agttcattat atatttcatg taggttgatg
     7621 tatccgttcg ttatgggatc acatcaacct acattcattt tcacttaaat ccataatccc
     7681 ttccgataat tgagaggagt ctgccccata ttcctcttga aaaacttaca gaaaccggca
     7741 gcatcactaa agccaagccg ggaagcaata tcccctaccg tagattttgt ggaactcagc
     7801 aaggtacggg cttccatgat cagtaactca ttaataatcg tattcacact ttttcccgtt
     7861 ccggcacgaa cgatacgtgc aaggtactgc tcactgatgg ccaacttatc cgcatagaaa
     7921 ctaacgaaat gctcttctct gaaatttcgg gtaacaagcg catgaaattc ctgtaaaaca
     7981 tggtctttac gactgacctc cttttttatg atagtcttac gggaaagaaa atcggctata
     8041 tccaaaaaca aggcattgca agccgcctgt attcgccgga aaagaaactg atgttttata
     8101 ttcagcaaac gcatcaacac ttccagttca ttacgaatga tttgagcttc gtatgcggtc
     8161 agctgtatgg tatattgctt attctgcctc atcgttgcca acagaatagc cgttatctgg
     8221 gtaagataag agtcatctgt ccgcatggac tcggaaatgg agagggtgat aaacttaata
     8281 tccggactcg aataaagatg atcggtgaga taattcgctc catgaacaag caacatatca
     8341 ggctctatca caataaattc cccattcagc aaaatctcgg aacgaccttc aagaacgagt
     8401 atcatataaa gttcacgatt aaagtaacgt tcgttttccg gatagctcct gtccttatat
     8461 tcactcataa agcagactac ttcctcttta taatgaggaa tttccggatg ttcctttaac
     8521 aactgcctat tatcaaaaat acgagatttt accatttata cctccttctt ttcgacgtaa
     8581 aaatacaatt tgtttcggat atgacaaaaa ctgtgtggaa tcggataact tatatcagac
     8641 gaaaaaacgg gacctttgca tattcttctt tatagaatga agaaaaatac gattatataa
     8701 gatagtaaga tatgggaatg aaagacgttt ttaaaaggta tttggtattt gttatcggat
     8761 tgtattttct ggctgccgga atagtgttga ttgtgcgttc tgcattagga accacaccta
     8821 tatccagcat caattatgtg ttaagcctga acagcccttt atcattagga acttgtacgt
     8881 ttctgatcaa tatgctgctt atcctgggac agttctgggt catcagaaaa aataggaccc
     8941 gacaggacac cattgaaata ctccttcaat tgccgttctc ttttatcttt tcggcattca
     9001 ttgattttaa tatggcgctc accagtaatc tgcatcccga caattacggg atgtcaatag
     9061 ccttattact cacaggatgc atgatacaat ccataggagt cgtactcgaa ctcaaaccca
     9121 aagtagcaat gatgagcgca gaggcttttg taaaatacgc ctcccgccgt tataacaaag
     9181 agtttggaaa gttcaaagtc tgttttgatg ttacgctggt cactctggca gtcatactct
     9241 ctctcctgct ttcacaatgc atcgaaggtg ttcgcgaggg gtctcttatc gccgcctgca
     9301 tcaccggata tatcgtcagc ttcctgaatc agaaaataat gacaaggaag actctctaca
     9361 aattattacc tgtattgaaa taagttttct ctagctcact accagcaacg tttccatctg
     9421 cctgacgata taaggtttcc actgaaccag aatatcctca aaagaatcat ccttctccaa
     9481 aaagaaagaa gcactgagat tctttgtcag gaaaggaact gtcaatgcac tataaaaagt
     9541 atagaatacg aatggcaaag gaactgtttt cagtctcccg tcattcattt cttcctgtaa
     9601 aacatccatg attttatgga gatattgttc caggcgcaac tccttgatag tatcgcttaa
     9661 atgattcata tcacgatgca tctccctcac catgaacaat ggcaaacatg gattttccgt
     9721 gaatacttta taataagcat ctacaatttc accgatactc tcggagacag gtttgtcctg
     9781 ctgaatgatt atatcatgta ttttgggaat aaaagaaagt atgatgttac caaaaacggc
     9841 ctgaaacatc ttatccttcg tccggaaata atagtgaagt gccggtctgt tgatacctac
     9901 tttagcagcg atatcactca tactggtttc tgcgaaccca ttctctataa atagttcttt
     9961 ggcagcctca attatctttt tctccaaatc ttcattatta ttagttgttg tcataattca
    10021 ttgtcgcatt tttcagatta tcaataaaca aaagcatacg gtttgttatg tttacgtcgc
    10081 tcacaccact atcaaagtct aaagatagca aatttatatc cggatagaaa ctttttatac
    10141 gtttttcgac tcctctggat acgatatgat tcgctatgca gccaaaaggt tgcaaactca
    10201 ctacattgtt caccccttgc cgggcgtaag acacgatttc agccggcaac aaccagcctt
    10261 caccgaattg ggcattcagc gaaataacgc ttttagctcc ttccgcttct tcaaagatat
    10321 cattgaaggg ggcaaagtaa cggaacttac ttgctgtctc atttatttta tcaatctgtt
    10381 tctttacaaa cttgtagatc cagtcgtaaa taaactcagg caactgtctg ttttttatgt
    10441 aagaatccgt attgactttc ctgttcacaa acccctgcat gaaaaagtca gccagaatcg
    10501 gcggaaccac ttctatcttg cggcctatca gccaatcaat gatctctttt tgtgcgaaag
    10561 gattgaattt caagaagatt tctcctacaa ttccgacttt aggagtatct acagccctac
    10621 acacctcatt aaattcagtg attgccgatt gcaacaaaga gttcaacccc tttatgtttc
    10681 ttctcagtat cacttcaggt gccagttgca ggtatttatc acgcagcttt gccgatgcac
    10741 ctgcttcttt ctcacgtacc acagacgcat aataaaactt agcaatgcaa tcactataca
    10801 aaacggcatg aaaagttatc ggtactactt tcatccagtt gaccttgaac gcgggctggt
    10861 cattatctat gtcactgccc acagagatag agattaccgg aatatccgta tatccggcat
    10921 ccaccaacgc cttttttatc aaggaaatat agttgctggc acggcattgt cctcccgttt
    10981 gggtgatggc tacggctatt tttgaaatat catatttccc gcttttaagt gcttttataa
    11041 tatcgccgac tatcagagta gccggataac agacctcatt attcgcatac ttcagccccc
    11101 attcacttga atcattatca ctgagaggaa ggttttccgc atcataaccg gctactttca
    11161 taatagcagg aatcaaaggt gaaatgaacg gagtaaagta aggaaccagt atcttacggt
    11221 cacggtaaga cttgtcatag acaggaacgg tcgtaaagtc ctttacatcg ccttccgttc
    11281 catccgcatt cgcaagtttg aggctttcaa tcatggaacg tactctcaac ttcattgaac
    11341 cgatattatt gatatcatcc agtttcaata aagtcagcga tttgttatga cgcatcagca
    11401 aatcccttac ttcatccacc agaaaagcat ccggtccaca tccgaacgaa gtcatctcta
    11461 caaactgaat attctttcct tgtgtcgcac accatttcgc agccttcagg atacggttcg
    11521 tatacgccca ttgagcaaca aaatgcgcat cacccgtcgg tatatccatc tgacgcacca
    11581 aatcatccgt tatcacattc actcccatat ccgaaagcat atccgagact ttgtgctgta
    11641 tcagagaatc ggtatgataa ggacgtccgg caagcatgac agtcagagtc tctccctttc
    11701 cagtctgctg caatatgttt ttgttataat cgaccaatgt attaataaaa gagtgctgtt
    11761 cgctttccgc tttttggaat gcttgctgaa tcgtccgatc gtccacgctc aaaccgctca
    11821 gatattcacg gcattgttta aacaacagat tccggtcttt gaaagttatt gcaggggaat
    11881 caaccgatat accttcggac tgcacacttt tgataacctc cgaataacct gtcacaatcg
    11941 gacaattata actgttttgt tccatccctt ttctttcgaa aataacaaaa ggcataaaaa
    12001 tccggtcgac cttcttttct atcaagtcct gaacatgact atgtaccagc ttagccggaa
    12061 agcagatatt gtccgacatc accatacgcg cattgtgctc atactttctg aaattggacg
    12121 gatcagacaa acagacttgt atgccacagg aagtgaaaag agtgtgccag aatggatatt
    12181 cctcgtacat attcagacat cgggggattc cgataatctg ctcgggtgct gcaatctctg
    12241 cgctgcgatg aaacaaaagc tcttcttttt gccgatagac attcagacct ttccggttac
    12301 tgctctctcc attcgtgaaa actttctcgc acctgtttcc cgaataataa cttttgccgc
    12361 tttcgaactc gtaacgaatg accagacaac gattatcgca actcttgcaa tataaagaac
    12421 gtgccgaata ttgagcttta ttgataatct catccaatga tacggactcc ccctgatgtt
    12481 tcatcgcata taatgcacat ccgaatgctc ccatcaattc gggtgtatca caccttgcca
    12541 cttccgctcc cgagagaagt tcaatggcac ggaccaccgc atcattgcgc atggtgcctc
    12601 cctgcacaac aatatctttt cccaaaacag atatatcttt cagtttcaac accttataca
    12661 ggcaattctt gacaacggaa tatgccagtc cggcggcaat atcattgatc gttgccccct
    12721 ccctgagtac ctgtttcact tttgagttca taaaaacggt gcaccttgtt cccaaatcac
    12781 acggtgcttc cgaatggcag gctgccagag aaaactcttg tgccgaatac cccagagatt
    12841 tagcaaacgt ttcaagaaaa gaaccacatc cggaagagca tgcttcatta atctccatcc
    12901 ggtcaatcac gccattattc acaaaaataa ccttcatatc ctgtccgccg atatcgagga
    12961 taaaagacac atccttgttc agataatgcg ctgccatata atgggcgatc gtttcgataa
    13021 tccccgaatg aagctgaaag gcagacctga taaggtcttc cccatatccg gtagaacagc
    13081 ttccttttat attgagtacg gcattctgct tcaaacattc atcgttcaac tgattcagcc
    13141 cctcttccac agcttttatc ggattgccgc cattaatatt ataataagaa tacagaagcc
    13201 ttgaatcttc atccagtaca acaatctttg tcgtagtaga acctgaatcg atgccgataa
    13261 agacatcctg tgttccggct ttcaagccgg aagatatcat cttatgacgg gatattcttt
    13321 ctttccatgc ttcatattct tcattacttg caaaaacagg ttccaatcct gttgaggcaa
    13381 ggttaccgtt accgtttaaa gtagtgtcaa tcttatcgat caaatgggac agtttacagt
    13441 aatcctcttt atcaagatga aatagagcag cacctagtgc agggagcaaa gtgccgttgg
    13501 ccggcagtat gatctctttt tcatcgaggg acaaataatc aatgaaggct ttccgcagtg
    13561 ccggaatgaa ggttaacgga ccaccgcaaa acaatacggg agttgtaata tcgcaaccgt
    13621 gcgccagcgt cactaccgtt tgaactgcta ccgcacgaaa gatggaagcc gcaatattct
    13681 cacgacttac atttttagct atcagattct gaatatccgt tttacagaaa acgccacaac
    13741 gggaggcaat aggatatacc tgtgtcgcat tcatggcaag ttgattcaat tcatcaatat
    13801 tcactcccag tataatcgcc atctggtcaa taaaagcgcc cgtccctcct gcgcaattgc
    13861 cgttcatacg caaatcggtc gcttcggcat ccttaaagaa gacgactttc gcatcttctc
    13921 ctccgatgtc tatcatagaa gtcacatgag aataatcctt ttgtatcgct ttcgctgccg
    13981 caacaacctc ctgtacaaac ggcaacgaac atttctctga aattcccatt ccgatagagc
    14041 ctgttatcct cacggaaata tctttatctc cgatttcaga taacccttaa ttccgcaaca
    14101 ctttgattta actttattta taagttcctg agcaacaaaa agttgctcag gattttgcca
    14161 tgtcagattt ttcacttatc ttagtgttgc aaatcaaaac aagcgtaaat cgtaacaaga
    14221 catggcaaag gtacaaataa aatctgaaaa act
//
