LOCUS       c00105_gnlPro..        16581 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DAMGHGEM_105.
ACCESSION   c00105_gnlPro..
VERSION     c00105_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-06 18:14:00
            Original ID  :: gnl|Prokka|DAMGHGEM_105
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16581
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16581
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3023:6581](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3024..6581
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16581
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16581
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             complement(451..1605)
                     /locus_tag="ctg105_1"
                     /transl_table=11
                     /translation="MALASGETNYMAPASARQMASDLALLPMWYAEAGSAVLAPSAYNA
                     DFLKTKSELLGMDVALLTEPEVADGKDRKFSPWGWDPALRKRLMTLGADQTELPSADYM
                     NILREHSHRLQAVKLLPGLRLNEYFCGESFYLSTLAECSAFVEGREACLLKAPLSGSGK
                     GLNWCKGIFTTFISGWCARVAASQGGVVGEPIYNKVEDFAMEFYADGRGRVVFAGYSVF
                     HTGGSGMYAGNDLLSDEKILQKLSAYVPQEEFIRLRTRLEEELSALFGGFYHGYLGVDM
                     MICHFPDEAPVYRIHPCVEINLRMNMGVVAWLLTDRYLAADAEGAFRIDYYPLAGQALE
                     EHRQMSASFPLSVENNRVCAGYLPLVPVTPQSRYRAFLLLTLPQ"
     CDS             1785..2990
                     /locus_tag="ctg105_2"
                     /transl_table=11
                     /translation="LPAEKQRNEMESFYRTHAYLVEHTNAPVRRDLMDEIDWSDRLIGI
                     KGTRGVGKTTFLLQYAKEKFGTDRSCLFINMNNFYFSGHSLVDFANEFQKRGGKVLLID
                     QVFKHPEWSKELRMCYDRFPSLKIVFTGSSVMRLKEENLELRDIAKSYNLRGFSFREFL
                     NLQTGMKFRAYSLEEILSTHEQIAKGVLSKVRPLDYFQDYLHHGFYPFFLEKRNFSENL
                     LKTMNMMVEVDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDVQTSRATVMN
                     YIKYLADARLINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVLDTFFVNTLW
                     KDHKVHKGDKNVSFMVDEVMPFKICAEGTKIKNNPDVTYALQKAEIGRGNQIPLWMFGF
                     LY"
     CDS             3024..6581
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg105_3"
                     /sec_met_domain="PFOR_II (E-value: 1.1e-18, bitscore: 58.2,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 1.6e-82, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 1.8e-31, bitscore: 100.3,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.3e-12, bitscore:
                     37.2, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 5.8e-12, bitscore: 37.2,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 1e-07, bitscore: 22.4,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 5.7e-05, bitscore: 14.4,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 2.7e-25, bitscore: 78.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMKPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDHLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKSIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQIISVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDTPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIAMEIGLGNRTNTILQSAFFRITGVIPV
                     DQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLTVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTSKYEKRGVAAFVPEWNAENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKAFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAEADNWTYCAENVKSKQHLVDIKANVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTMNEKGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARLVKVMNEAIASDCCPAEYKEVFAEWINNMLDAEKTKE
                     LAEKIIPMVEAAKDKCNHCKQIADLQQYLVKRSQWIIGGDGASYDIGYGGLDHVIASGK
                     DVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQIA
                     MGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLWR
                     YNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPAEAEELFKAAEENAKW
                     RYNSYKRLARENWGADTAE"
     CDS             6706..6894
                     /locus_tag="ctg105_4"
                     /transl_table=11
                     /translation="MIGFVIWIVGLILTFRAAIEIWNINAAVEKRLIAIVLIVLTSWLG
                     LLFYYFYGKERMAGWLK"
     CDS             complement(6905..7765)
                     /locus_tag="ctg105_5"
                     /transl_table=11
                     /translation="MNKIKMIAAMFIAGILLTFVSCGDNGKSKKISIAYANWSEGIAMT
                     NLAKAIFEDQGYDVKLLNADLAPIFTSISRKKADVFMDVWMPVTMEDYMKQYGDKLEVI
                     GDIYDGARIGLVVPDYVTINSIEELNAEKERFSGQIVGIDAGAGIMKATDQAIKDYGLD
                     YKLMTSSGPAMTASLKKAIDKKDWIVVTGWTPHWMFDRFKLKVLQDPKLIYGNAETIHT
                     IAWKGFSEKDPFAAELLGNIRLTDAEISSLMTALEEAQTTERQAARQWMEEHQELVNSW
                     IPKKD"
     CDS             complement(7793..8623)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 91.7; E-value: 1.6e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg105_6"
                     /sec_met_domain="BPD_transp_1 (E-value: 6.5e-29, bitscore:
                     91.7, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIETAINWLTEHFASFFDALSMGIGGFIDGFQHVLFGIP
                     FYITIAVLAALAWFKSGKGTAVFTLLGLLLIYGMGFWEETMQTLALVLSSTCLALLLGV
                     PLGIWTANSDRCNKIMRPVLDFMQTMPAFVYLIPAVLFFGLGTVPGAFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATPWQLLYKVQLPLALPTILTGINQTIMMSLSMVVIA
                     AMISAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIVLDRITQGMADNRKSKKK"
     CDS             complement(8620..9846)
                     /locus_tag="ctg105_7"
                     /transl_table=11
                     /translation="MSKIEIKDLYLVFGNEKQKALKMLKEGKTKSEILKATGCTVAVKD
                     ANLSINEGEIFVIMGLSGSGKSTLLRCINRLIRPTSGEVIINGTDIAKVSDKELLQIRR
                     KELAMVFQNFGLLPHRSVLHNIAFGLELQGVKKEEREKKAMESMQLVGLKGYENQMVSE
                     LSGGMQQRVGLVRALANNPEVLLMDEAFSALDPLIRVQMQDELLTLQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEIVQIGTSEEILTEPANAYVERFVENVDRSKIITASSVMVD
                     KPIVARLKKEGPEVLIRKMRERNLTVLPVVDSNNLLVGEVRLNDLLKLRKEQIRSIESV
                     VRHEVHSVLGDTVLEDILPLMTKTNSPIWVVNENREFEGVVPLSSLIIEVTGKDKEEIN
                     EIIQNAIEL"
     CDS             10320..11606
                     /locus_tag="ctg105_8"
                     /transl_table=11
                     /translation="MFNRAITIFLGKDNCHYTTKEKQTGTATLDDKSQVQFLSKKNPKM
                     PFFYSRRNLYMIGFLLAFIVTLLEFMRGRHQNFMVFSDATQFFWQGISPYTTEFVEAHG
                     RYFLYSPVFTVLFAPFAYLPAWLGPFAWNLFNYSLFFVAIFTLPQQFTQQQKCRMFLFL
                     LLILGQSLLSFQYNITVAYLFLFAYTLLEKDRGFLAVLLIMISGCTKVYGIFELALLLC
                     YPHVWRNFGYAVAMGIVLLTLPLIKIAPADLLPYYEEWCHSLAVHQSAGAYDSFFYARP
                     IAAWTLPHFRALQIGMLGLLTLLFLGNFHKWSSFAFRAQALGILMGWVVLLSDSAEKHT
                     YIIALAGFMLWYWSRPTRTATDKILFWCCFVLLCIVPIDIFVPVPIRDFITRTLWLHVW
                     VFFIVWIRMIWLTFLASFIHPRATNVLSD"
     CDS             complement(11569..11901)
                     /locus_tag="ctg105_9"
                     /transl_table=11
                     /translation="MKDYKVDKESFSESFRKEVYEVVSQIPVGKVSTYGGIALLLGAPQ
                     CSRMVGRALKEVPDELSIPCHRVVNSTGRLVPGWVEQKQLLLAEEVSFKANGCVNLKEH
                     LWHVDE"
     CDS             complement(11929..14550)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 60.9; E-value: 4.4e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg105_10"
                     /sec_met_domain="Peripla_BP_1 (E-value: 1.8e-19, bitscore:
                     60.9, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNDEILREAMFYNGVSVEIRSAGDDNTKQAEDVHYFMDEGVDLLI
                     ISANEAAPMTPIVEEAYQKGIPVILVDRKILSDKYTAYIGADNYEIGRSVGNYIASSLK
                     GKGNIVELTGLSGSTPAMERHQGFMAAISKFPDIKLIDKADAAWERGPAEIEMDSMLRR
                     HPKIDAVYAHNDRIAPGAYQAAKMAGREKEMIFVGIDALPGKGNGLELVLDSVLDATFI
                     YPTNGDKVLQLAMDILEKKPYPKETVMNTAVVDRTNAHVMQLQTTHISELDKKIETLNG
                     RIGGYLSQVATQQVVLYGSLIILLLVAGLLLVVYKSLRSKNRLNKELFKQKQQLEEQRD
                     KLEEQRDQLIQLSHQLEEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADKTLSGDQH
                     RMLMLIQRNVNILLRLVNQILDFRKYENGKMEYTPVTVDVLSSFEGWNESFQAAARKKH
                     IHFSFDSMPDTDYHTLADMEKLERIYFNLLSNAFKFTPENGRIAVRLSSLCKEDKRWIR
                     FTVANTGSMISAEHIRNVFDRFYKIDMHHTGSGIGLALVKAFVEMHGGTISVESDEKQG
                     TVFTVELPVQSCEAVAAEPDTTLVSADSRTTDVLLAEEEELEKGYDSSKSSVLIIDDNE
                     DIRSYVHTLLHTDYTVIEAADGSEGIRKAMKYVPDLIISDVMMPGIDGIECCRRLKSEL
                     QTCHIPVILLTACSLDEQRIQGYDGGADSYISKPFSSQLLLARVRNLIDSHRRLKQFFG
                     DGQTLAKEDVCDMDKDFVERFKSLIEEKMGDSGLNVEDLGKDMGLSRVQLYRKIKSLTN
                     YSPNELLRIARLKKAASLLASSDMTVAEIGYEVGFSSPSYFTKCYKEQFGESPTDFLKR
                     KG"
     CDS             complement(15015..16241)
                     /locus_tag="ctg105_11"
                     /transl_table=11
                     /translation="MFFSLIVPLFLSLFYKPIAYLCGRSLNNKSKRENYFMKHISNFLR
                     SKSWNVFLFLYLALPLFAQKEYKIDQVSVVNVGDGRLLFQELKTEKALNGEHRIIDGYH
                     SAYVLASFKDGFYDGGYKEYVDNILITEGSYKEGRKDGLFKINSKFDGKLKEEKSYKEG
                     KLDGTSKSYFTTGKVESERNFRMGKEHGKQLSYESDGTLRKEHNYKDGKQVGKQYTFLK
                     GTYDLYETVYFNEEGFQDGEYSSVFTFGSPRILGSYKNGKKNGRWTTFAESGDTLMIET
                     YLDGKEDGLHVSFANGSGVRQKEYYMKNDRKDGLYREYNLENGELRYEATYQAGRLHGK
                     ERRLIVSNRFDYWETSTYVNGRQNGPFEARYVKNDQLRECGEYKNGRRVGRWKRYTIDG
                     KLEKEWDEN"
ORIGIN
        1 aggtcatgtc actctttttc atcttttatt cattttagtt gatacttata gtagtcaacc
       61 aaatccaggg taagacaact actgttgatt tgattgactt aaccgcatgt tccaatcaca
      121 ttgaacgcat cagctacttc aatagtactg ctctctctga aaacattaaa tcatatatca
      181 gtcaataata cataaattat cagtccttaa tacttgattt ctcaattatt aatatctgag
      241 aaatcaaacg ttaacagttg agatatcaga tattaacatc ctgtaaatca aagaataaca
      301 cagtaaaaac ggtatttatc aggacgatgc agagtgagag caagtccttg ctctcactct
      361 gctaccactg gatctctaac agctaaaaca tcgatgaata aagggataca gacgaactgt
      421 tagagcatga gagcaaaagc actatctttt tcactggggg agagtaagca aaagaaacgc
      481 acgataccgg ctttgaggcg tcaccggtac taacggcaaa tatccggcac acacccgatt
      541 attctctacg gacaaaggga acgaagccga catctgccga tgttcctcca aagcctgacc
      601 ggctaaagga taataatcaa tccgaaaagc tccttccgca tccgcagcca aataacgatc
      661 cgtcaagagc catgccacca cccccatatt cattcgcaga ttaatttcga cacaaggatg
      721 aatccggtaa acaggcgctt catccggaaa atgacaaatc atcatatcca ctcccaagta
      781 tccatgataa aagccaccga acaaagctga caattcttct tccaaacgag tccgcagcct
      841 gataaattct tcttgtggca cataagccga tagtttctgc agaatcttct cgtcagacag
      901 caagtcattc cctgcataca tcccactccc acccgtgtgg aagaccgaat atccggcaaa
      961 aacaaccctt cctctcccgt cagcataaaa ctccatagcg aaatcttcca ccttattata
     1021 tataggttcg cctaccaccc caccctgaga agcagcgaca cgggcacacc aaccggaaat
     1081 aaaagtagta aatatgcctt tacaccaatt caatcctttc ccgcttccgg aaagcggagc
     1141 ttttaacaag cacgcttccc gcccttcgac gaacgcactg cactccgcca aagtactcaa
     1201 ataaaaagat tctccacaga agtattcatt caaccgcaac ccaggcaaca actttaccgc
     1261 ctgcagacga tgcgaatgct ctctcagaat attcatataa tccgcagaag gcagctccgt
     1321 ctgatctgcc cccaatgtca tcaaacgctt ccgcaaagca gggtcccacc cccacggaga
     1381 gaacttccgg tctttaccgt cagccacttc cggttccgtc aacaaggcca catccatgcc
     1441 caaaagttca ctctttgttt tcaggaagtc cgcattataa gcagacggtg caagcaccgc
     1501 acttcccgct tcggcatacc acataggaag caacgccagg tcactcgcca tctgtcgggc
     1561 ggaagccggc gccatatagt tcgtctcacc gcttgccaac gccatatcat gctccggatt
     1621 gaatatataa acaggtcttt tcgtcatgtc aaagatggat tcaacacatt attctgcaaa
     1681 tatatacagg aaataatcag gaacttacac aataaagaga aacttataaa ttaaagcaca
     1741 tttttgctat ctctactttg caaatcctaa aaaaagcact atatttgcca gccgaaaaac
     1801 aaagaaacga aatggaatca ttctatcgca cacacgccta cctcgttgag cacaccaatg
     1861 cccccgttcg ccgcgatctt atggacgaga tcgactggag tgaccgtctg attggtatca
     1921 aagggacacg tggcgtagga aaaaccactt tcctcctgca gtacgccaaa gagaaattcg
     1981 gcaccgaccg ttcctgtctg ttcatcaata tgaacaactt ttatttctcc ggtcacagcc
     2041 ttgttgactt cgccaacgag tttcagaaac gtggcggaaa agtactgctg atcgaccagg
     2101 tgttcaaaca tcccgaatgg agcaaagagc tacgaatgtg ctatgaccgt ttccccagcc
     2161 tgaagattgt cttcaccggt tcttccgtca tgcgactcaa agaggaaaac ctcgaattgc
     2221 gtgacattgc gaaaagttat aacctgcgcg gattctcttt ccgtgaattt ctgaacctgc
     2281 agacaggaat gaaattccgg gcatacagcc tcgaagaaat cctcagtaca catgaacaga
     2341 tagccaaagg agtactttcc aaagtacgac cgctggatta ttttcaggat tacctgcatc
     2401 atggtttcta ccctttcttc cttgaaaaac gtaatttctc ggagaatctg ctgaaaacaa
     2461 tgaacatgat ggtagaagtg gatatcttgc tgatcaaaca aattgagctg aaatatcttt
     2521 caaagataaa aaaattacta tatttgttgg ctgtggacgg accgaaagct ccgaacgtga
     2581 gccaactggc aagtgacgta cagacatccc gcgctacggt aatgaactat atcaagtatc
     2641 tggcagacgc gcgtctgatt aatctggttt acccgaaagg agaagaattc ccaaagaaac
     2701 cgtcaaagat tatgatgcac aactctaacc tgatgtactc catttatccg gtgaaagtgg
     2761 aagaacagga tgtactcgac acgttcttcg ttaacacttt atggaaagac cataaggtac
     2821 ataaaggaga taaaaacgtc tctttcatgg tagacgaagt gatgccgttc aaaatttgtg
     2881 cggaaggtac aaaaataaag aataacccgg acgtgacgta tgcgttgcaa aaggctgaga
     2941 taggccgcgg caaccaaata cctctttgga tgttcggatt cttatactaa aaagatttat
     3001 ttacttaaat atttaattta gttatgacta aacagaagaa attcatcaca tgtgatggta
     3061 accaagctgc agcacatatc tcgtatatgt tctctgaagt agcagctatc taccccatca
     3121 ctccttcttc gactatggct gagtacgtag acgaatgggc tgccgcagga cgtaagaaca
     3181 tcttcggcga aacagtattg gtacaggaaa tgcaatctga aggtggtgct gccggtgcag
     3241 ttcacggttc tcttcaggct ggtgcattga ctactactta cactgcttct cagggtcttc
     3301 ttttgatgat ccctaacatg tacaagattg ccggtgaatt cttgccttgt gtattccacg
     3361 tttctgctcg tacactggct tctcacgcat tgtgtatctt cggtgaccat caggacgtaa
     3421 tgtcagctcg tcaaaccggc ttcgctatgt tggcagaagg ttctgtacag gaagttatgg
     3481 atttggcagg tgttgctcat ctggctacta tcaaatcacg cgttccgttc atgaacttct
     3541 tcgatggttt ccgtacttct cacgaaatcc agaagatcga aatgttggaa aacgacgacc
     3601 tcgctccgct gatcgaccag gaagctttgg ctgaattccg tgcccgtgca ctgaatccga
     3661 tgaagccggt tgcccgtggt atggctgaaa accccgacca cttcttccaa catcgtgaat
     3721 catgcaataa ctactatgaa gcagttcctg ctatcgtaga agaatacatg aacgaaattt
     3781 ccaagatcac aggccgcaaa tacggtttgt tcgattacta cggtgcagaa gatgcagaac
     3841 gcgtaattat cgcaatgggt tctgtaactg aagctgcccg cgaagctatc gaccacttgg
     3901 tagcaaacgg cgaaaaagta ggtatggttg ccgtacactt gtatcgtccg ttctctgcta
     3961 aacacttcct ggctgctgta cccaagactg caaagagcat cgcagtgctt gaccgtacaa
     4021 aagaaccggg tgctaacggc gaacctcttt accttgacgt taaagactgc ttctatggcg
     4081 cagaaaatgc tcctgttatc gttggcggtc gctacggtct gggttcaaaa gataccactc
     4141 cggcacagat catctctgta ttcgaaaact tggctatgcc aatgccgaag aaccacttca
     4201 ctatcggtat cgtagacgac gttacgttca cttctcttcc tcagaaagaa gaaatcgctc
     4261 tgggcggtga aggtatgttc gaagctaaat tctacggtct gggtgctgac ggtacagtag
     4321 gtgccaacaa gaactctgtt aagattatcg gtgacaacac cgacaaacac tgtcaggctt
     4381 acttctctta cgactccaag aagtcgggtg gtttcacttg ttctcacctg cgtttcggtg
     4441 atactccgat ccgttctact tacttggtaa atactccgaa cttcgttgct tgtcacgttc
     4501 aggcttacct gcacatgtac gatgtaacac gtggtttgcg taagaacggt tctttcttgc
     4561 tgaacaccat ctgggaaggc gaagaactgg ctaagaacct gcctaacaag gtgaagaaat
     4621 actttgcaca gaacaacatc tctgtatact atatcaacgc aactcagatt gcaatggaaa
     4681 ttggtctggg caaccgtacc aatacaatcc ttcagtctgc attcttccgt atcacaggcg
     4741 ttattcctgt agatcaagct gttgaacaga tgaagaaatt catcgttaag tcttacggca
     4801 agaagggtga agacgttgtt aacaagaact acgctgctgt agaccgcggt ggtgaataca
     4861 agactctgac tgtcgatcct gcttgggcta acctgccgga tgatgcaaaa gcagaaaaca
     4921 atgatcctgc tttcatcaac gaagtagttc gtccgatcaa tgcacaggac ggtgacttgc
     4981 tgccggtatc tgcattcaag ggtatcgaag acggtacttg gtatcaaggt acttccaaat
     5041 acgaaaaacg tggtgtagct gcattcgttc ccgaatggaa tgctgaaaac tgtattcagt
     5101 gtaacaagtg tgcttacgtt tgtcctcacg cttctatccg tccgttcgta ctcgatgctg
     5161 aagagcagaa gggtgctaag ttcgagcaac tgaaagctgt aggtaaagca ttcgatggta
     5221 tgacattccg tattcaggta gacgttctcg actgtctggg ttgcggtaac tgtgccgaca
     5281 tctgtccggg taatccgaag aagggtggca aggcattgac catgaaacac cttgaaagcc
     5341 agttggccga agctgataac tggacttact gcgctgaaaa cgtgaagagc aaacaacacc
     5401 tggtagacat caaggctaac gtgaagaact ctcagttcgc aactccgttg tttgagttct
     5461 caggcgcttg ctccggttgt ggtgaaactc cgtacgtgaa actgatttct cagttgttcg
     5521 gtgaccgtga aatggttgct aacgctacag gatgttcttc tatctactca ggttcagttc
     5581 cttctactcc gtacactatg aacgaaaagg gtcacggtcc tgcatgggct aactccttgt
     5641 tcgaagactt ctgtgaattt ggtctgggta tggaactggc taacgaaaaa atgcgtgccc
     5701 gtctggtgaa agtaatgaac gaagctatcg cttctgattg ctgcccagct gaatacaaag
     5761 aagtattcgc tgaatggatc aacaatatgc tggatgcaga aaagactaag gaactggctg
     5821 aaaagatcat tccgatggta gaagctgcta aagataaatg caaccactgc aagcaaatcg
     5881 ctgatctgca acaatatctt gttaaacgta gccaatggat catcggtggt gacggtgctt
     5941 cttacgatat cggttacggt ggtcttgacc atgtaatcgc ttccggtaag gacgttaaca
     6001 tccttgtatt ggatactgag gtttactcta acacaggtgg tcagtcttct aaagctactc
     6061 cggtaggcgc tatcgctaag tttgctgctg caggtaagcg tgtacgtaag aaagacctcg
     6121 gtctgatggc tactacttac ggttatgtat atgttgctca gattgctatg ggtgctgacc
     6181 aggctcagac tctgaaagcc atccgcgaag ctgaagcata tccgggacca tcactgatca
     6241 tcgcttacgc tccatgtatc aaccacggtc tgaaagccgg tatgggtaag agccaggaag
     6301 aagaagaaaa ggctgttaag tgcggttact ggcacttgtg gcgttacaac cctgctttgg
     6361 aagaagaagg caagaatccg ttccagctgg atagcaaaga acctaactgg gaagacttcc
     6421 aaggtttctt gaagggtgaa gttcgttacg cttctgtaat gaaacaatac cctgctgaag
     6481 ctgaagaact gtttaaagct gctgaagaaa acgctaaatg gcgttacaac agctacaaac
     6541 gtcttgccag agaaaactgg ggagctgata cagctgaata ataagtagaa atactttgta
     6601 cataataaaa ggcaggaatc ctggaaacag attcctgcct tttttgttta tatattagaa
     6661 gtaacgatta cttctcacga agatattcat taaaactcta aagatatgat cggatttgtt
     6721 atttggattg tcggtttgat actgactttc agagctgcca tagagatttg gaatataaat
     6781 gcggctgtag agaaaaggct tatagcgatt gtattaatcg ttcttaccag ctggctggga
     6841 ctacttttct actacttcta tggtaaagaa agaatggcgg gatggttgaa gtagtgtttg
     6901 cttatcaatc tttcttagga atccaactgt ttaccagttc ctgatgttct tccatccatt
     6961 gacgggcagc ctgtctttcc gtcgtctgcg cctcttccag agcagtcatt aaagagctga
     7021 tttccgcatc agtcagacga atattgccca gaagttcggc agcaaaagga tctttctcgc
     7081 taaaaccttt ccacgctatg gtatgaatgg tttccgcatt tccatatatc agcttcgggt
     7141 cctgaagaac tttcagtttg aaacggtcga acatccagtg aggcgtccat cccgtcacga
     7201 caatccagtc tttcttatca atcgctttct ttagggaagc agtcatggca ggtccgctcg
     7261 aagtcatcag tttataatcc aatccatagt ctttgatggc ctgatcggta gctttcataa
     7321 taccggctcc ggcatcaata ccgacaatct gaccggagaa acgttccttt tccgcgttca
     7381 gttcttcgat cgagttgatc gtaacgtaat ccggaaccac cagcccgata cgggcaccat
     7441 cataaatatc cccgataact tcgagtttat ccccgtattg tttcatataa tcttccatag
     7501 tgacaggcat ccagacatcc ataaatacgt ctgctttctt acgggagata gaggtaaata
     7561 taggtgcaag gtcggcattc agcaacttta catcgtatcc ctgatcttca aaaatcgctt
     7621 tggcaaggtt tgtcatggca atcccttccg accagttggc ataagcgata cttatcttct
     7681 tactctttcc gttgtctccg caggaaacga aggttaagag tatgccggca ataaacattg
     7741 ccgcaatcat ttttatctta ttcattgatt attcctttct ttggtgtgat tcttatttct
     7801 ttttactttt tctgttatct gccatgccct gagtgatgcg gtccagcacg atcgccaata
     7861 tcacgactgc gataccgcct tcaaatccga gtccgatttt catttgggtg atacctttca
     7921 gcacgatttc tcccaatcct ccggcagaaa tcatggcggc aatcactacc atcgaaagtg
     7981 acatcatgat cgtctggttg attcccgtca gaatagtagg caacgccaaa ggcaattgta
     8041 ccttataaag aagctgccag ggagtagctc caaaagagcg ggaggcttct actacgtttt
     8101 taggaacctg acgaatgccc aggccggtca gacgaaccac aggaggcatt gcaaagatga
     8161 tggtggcaaa agctcccggc acagttccca atccgaagaa tagaacggca ggaatcagat
     8221 agacaaaggc aggcattgtc tgcataaagt cgaggacagg gcgcattatc ttgttacaac
     8281 gatcactgtt ggcagtccag attcccagcg gaacgcctaa aagcaatgcc agacaagtgg
     8341 aagaaagtac taacgccaat gtctgcatcg tttcttccca aaagcccatg ccgtaaataa
     8401 gcaataagcc caagagggta aatacggctg tccccttacc cgacttaaac caggcgagcg
     8461 cagccagcac tgcaattgtg atataaaaag gtattccaaa cagtacgtgc tgaaaaccgt
     8521 ctatgaatcc tccgatcccc atgctgagag catcaaaaaa ggaagcaaaa tgttctgtga
     8581 gccaattaat ggcagtttct atatattgtc cgatatttat cataattcta ttgcgttttg
     8641 aatgatttca ttaatttctt ctttatcttt tcccgttact tcgatgatca atgaggaaag
     8701 tggcactacg ccttcaaact cccgattctc atttacgacc cagattggcg agttcgtttt
     8761 tgtcatcaac ggaagaatat cttccagcac cgtatcaccc agcactgaat gaacttcatg
     8821 ccttactacg gactcgatgg agcggatttg ctcttttcgt agtttcagca agtcattcaa
     8881 ccgcacctct cctactaaca gattattgga atcgactacc ggaagaacgg tcagattccg
     8941 ttcgcgcatc ttacggatca gcacctccgg gccttctttc ttcaaacgtg ccactatggg
     9001 tttatctacc ataacagagg aagctgttat aatcttgctt cgatctacat tctccacaaa
     9061 tcgttctaca taagcgttgg caggttcggt caggatttct tccgatgtac cgatttgtac
     9121 aatttctcca tccttcatga tagcaatccg gtcacccaat ttaatcgctt cactcaggtc
     9181 gtgagtaata aagacaatcg tttttttcat cttcgactgc aaagtcagca gttcatcctg
     9241 catctgcaca cggatcaaag gatcgagtgc cgagaaggcc tcatccatca acaggacttc
     9301 gggattattg gccaaagccc gcaccagccc gacacgctgc tgcatcccac ccgacagttc
     9361 acttaccatc tgattctcgt agcctttcag ccccaccagt tgcatacttt ccatcgcttt
     9421 cttctcccgt tcttcctttt taactccctg tagttcgagt ccgaaagcta tattatgcaa
     9481 gacagaacgg tgaggaagca gaccgaagtt ctgaaagacc atagccagtt ctttccggcg
     9541 aatctgcaac agttctttat ccgacacttt ggctatgtct gttccattga taatcacttc
     9601 tccggaagta gggcgtatca aacggttgat gcagcggagt aaagtggact ttccactacc
     9661 ggacaacccc ataatgacga atatttcgcc ttcattaatg gaaagattcg catctttcac
     9721 cgcaaccgta catccggtcg ctttcaatat ttcactttta gttttacctt ctttcaacat
     9781 cttcaaagcc ttctgcttct cattgccaaa aaccagatag agatctttaa tttctatttt
     9841 actcatacaa taaaatggtt taggttatta aaataatata cacagcaaga caagaacaaa
     9901 cgataacagg aatctttctt tatatcgtat aaagttctga tttaaatacg ggacaaataa
     9961 caatgaatcc cgaaataatt aataaaatga ttattgacag actgagtaat taaaaaagga
    10021 atagaatttg ataagataat cctttcaacg aatagcaaaa aaatagcatt tttatgtata
    10081 aaaacagtct gttccagtat cttgctggca caaagataca aaaaacagat taaacatgca
    10141 aattatattc aaaatccggg gcatacagag gactttattt gtaatgatat ggaaagtttc
    10201 cgggtaatat tcccctatca ctcagcaaaa tagaacaaac cagcagataa atataaaata
    10261 agtttgaata tttcacctaa acaccgtata tttggcgtca ataactaaac tagatttata
    10321 tgttcaacag ggctattaca attttcctgg ggaaggataa ttgtcattac acaacaaaag
    10381 aaaaacaaac aggtactgcc acactagacg acaaaagcca agtacagttc cttagtaaaa
    10441 agaaccccaa aatgccgttt ttctatagtc ggcggaatct ctacatgata ggtttcctgc
    10501 tcgcttttat agtgactctg ctcgaattta tgcgaggacg gcatcaaaac tttatggtct
    10561 tctcagacgc tactcaattc ttctggcaag gcatcagccc atacacaacc gaatttgtag
    10621 aagctcacgg acgctacttc ctttattctc ctgttttcac ggtattgttc gctccgtttg
    10681 cgtatctgcc tgcatggctg ggacctttcg cgtggaatct attcaattat tcattgttct
    10741 ttgtggcgat cttcacgctg ccccaacaat tcacccagca acagaaatgc cgtatgttcc
    10801 tttttctgtt actgatttta ggacaaagtt tactttcatt tcagtataac ataacggtag
    10861 cctatttatt cttattcgcc tatacgttat tggaaaaaga ccgtggattt ctggctgttc
    10921 tgttaatcat gatttcggga tgtaccaaag tatatggaat tttcgaactg gcattgttgc
    10981 tgtgctatcc tcacgtatgg cgtaactttg gctatgccgt tgcaatgggc attgtattgc
    11041 ttacgttacc gttaatcaaa atagctcctg cagatttgct cccctattat gaagaatggt
    11101 gccatagtct tgctgttcat caatccgccg gagcttatga ttcatttttc tatgcccgcc
    11161 ccattgcagc atggacattg ccacacttcc gtgcacttca gataggaatg ctcggtctac
    11221 tgactctgct ctttttgggg aatttccaca aatggtcgtc ttttgccttc cgtgcccaag
    11281 ctttgggcat tctcatgggc tgggtagtat tactgagtga ctccgccgag aaacatacct
    11341 atattatcgc attggcaggt ttcatgctct ggtattggag caggccaaca cgtaccgcaa
    11401 cagacaagat tctattttgg tgctgttttg tgctgttatg catcgttcct atcgacatat
    11461 tcgtccctgt tcccatcaga gatttcatta ccaggacctt atggcttcat gtatgggttt
    11521 tctttattgt atggatacgg atgatatggc ttaccttcct tgcatccttc attcatccac
    11581 gtgccacaaa tgttctttca gattaacgca tccgttagct ttgaaagaaa cttcttctgc
    11641 cagcaagagt tgtttttgtt ccacccaacc gggtaccagc cttccggtgg aatttacaac
    11701 tctatggcaa ggaatggata attcatccgg cacttctttc aatgcacgcc ccaccatccg
    11761 cgaacattgg ggggcaccca aaagcaaagc aatacctcca taggtagata cttttcccac
    11821 aggtatctgg gatacgactt cgtacacttc cttccgaaag gattcggaaa aactctcttt
    11881 atctacttta taatctttca tatatccctc tttacgatct caatgaaatc atcctttcct
    11941 tttcaggaag tctgtcgggc tctctccgaa ctgctcttta tagcacttgg tgaaataaga
    12001 aggtgaactg aaaccgactt cataaccaat ctccgctacg gtcatgtccg aagaagcaag
    12061 caaagaagct gccttcttca aacgggcgat acggagcaat tcattcggag agtagttagt
    12121 caacgattta atcttgcggt aaagctgcac acggcttagt cccatatcct tgcccaagtc
    12181 ctccacattc aaaccggagt ctcccatttt ctcttcaatc aatgacttga atctttctac
    12241 aaaatccttg tccatatcgc aaacatcttc cttcgccaat gtctgcccgt caccaaagaa
    12301 ctgtttcaga cgacggtgag aatcgatcag gttgcggaca cgtgccagca acagttgtga
    12361 actgaacggc tttgaaatat aagaatcggc accaccgtca tatccctgaa tacgctgttc
    12421 gtccagtgaa cacgccgtca gcagaataac cggaatatga caggtctgta actcactttt
    12481 cagccggcgg caacattcaa tgccatcaat gcccggcatc atcacatcgg aaataatcag
    12541 gtcaggaaca tacttcatag ccttacggat tccttcggag ccgtctgccg cttcaatcac
    12601 cgtatagtct gtatgcaaca gcgtatggac atacgaacgg atatcctcat tatcatcaat
    12661 aatcagtacg gacgatttgg aagagtcata tcctttttcc agttcttcct cttccgccaa
    12721 tagaacatct gttgtacggg aatccgcaga aacaagggtg gtatccggtt cggcagcaac
    12781 agcctcgcaa gactgtacag gcagttcaac ggtaaagacc gtaccctgtt tctcatcgct
    12841 ctctacagag atcgtaccac catgcatttc tacgaaggct tttaccaatg ccagtccgat
    12901 tcccgaaccg gtatggtgca tatcgatctt atagaaacgg tcgaatacat tgcggatatg
    12961 ttcggcagaa atcatagaac cggtatttgc caccgtgaaa cgtatccatc gcttgtcctc
    13021 tttacaaagg gaagacagac gaacggcaat tcttccattt tccggtgtaa acttaaaggc
    13081 attggacagg agattgaaat aaatacgttc cagcttctcc atgtctgcca gtgtatgata
    13141 atccgtatcc ggcatactat caaaagaaaa atggatatgc ttcttacggg ctgccgcctg
    13201 aaaagactca ttccatcctt cgaaagaaga aaggacatcc accgtaaccg gagtatattc
    13261 catcttgcca ttttcatatt tacggaaatc cagaatctga ttgaccagac gcagaagaat
    13321 gttcacattc cgctgaatca gcatgagcat ccggtgctga tctccgctca gtgtcttgtc
    13381 cgccaacaaa tgttctaccg gatcggcaac caatgtcaac ggagtacgga agtcgtgaga
    13441 aatattggtg aagaatacca gcttggcatg agtagcttct tccagttgat gagaaagttg
    13501 tatcaattgg tcacgctgtt cttccagttt gtcacgttgc tcttccaatt gttgcttctg
    13561 cttaaaaagt tctttattca agcgattctt tgagcggagt gatttataaa cgaccaataa
    13621 taagccggct accaataaaa ggataatcag actgccgtat aaaacgacct gttgtgtagc
    13681 tacctgagag agatagccac cgatacgtcc gttgagcgtt tcaatctttt tgtcgagttc
    13741 ggaaatgtgt gtggtctgca actgcatgac gtgtgcgttg gtacggtcca caacagcggt
    13801 attcatcacc gtttctttgg gatagggttt cttctccaga atatccatag ccagttgcag
    13861 taccttatca ccattggtcg gatagataaa ggtagcatcc agcacactgt ccagaaccag
    13921 ctccagcccg tttcccttac ccggcaaggc atctatgccg acaaaaatca tttccttctc
    13981 ccgccctgcc atctttgctg cctgataggc acccggagcg atacgatcat tatgggcata
    14041 cacagcatca atcttaggat gcctccgaag catactatcc atttctatct ctgccggacc
    14101 acgttcccaa gcagcatccg ctttatcaat cagctttata tccgggaatt tactgatggc
    14161 agccataaat ccctgatgcc gttccattgc aggagtcgaa ccgctcaatc ctgtcagttc
    14221 tactatattt cccttccctt tcagactgga ggcaatatag tttcctaccg aacgaccgat
    14281 ttcataatta tcggctccga tataggcagt atatttatcc gaaagaatct tccggtctac
    14341 aagaataacg gggatgcctt tctgataagc ttcttctaca atcggagtca taggagcagc
    14401 ttcgttagcg gaaataatca gcagatcgac tccttcgtcc ataaaataat ggacatcttc
    14461 cgcctgctta gtgttatcat cccctgccga acggatttcc accgaaacac cattataaaa
    14521 catcgcttcc cgaagaatct catcattcat cttatgtcgc catgaatcat cgctgcattg
    14581 agccacccca atacgaaaac ggggtgtatc ctgccggcaa gccgtcatcc cggttaaaca
    14641 aaacagcacc agcatccact tcagatatct catcgtcttc atccatctca tcatttcgta
    14701 gttctttctg taatccaatt aagaacaaaa ataagaaata atactgtaaa gttctctaac
    14761 ttcagctatt tattattcta aaaagaagga aagcagtcct ctttcagacc atcggaaagt
    14821 attaacaaaa gtataaagcg taaaacaaac acttaatcaa tgttataaaa catagcgttt
    14881 tacttggata atttgcagat ttcacagaag tccgtatctt tgtactgtgt ttttcatagt
    14941 attagattta aggttaacaa aggttggagc aaggcgttgc tccttttttt atgccctgac
    15001 ctttcatcta ccggttagtt ttcatcccat tccttttcca gtttaccatc aatagtgtag
    15061 cgtttccatc gtcctacacg gcgaccattc ttatattccc cacattcacg aagctggtca
    15121 ttctttacat aacgagcttc gaacggtccg ttctgccttc cgttcacata ggtagaagtt
    15181 tcccaataat caaagcggtt gctcactatc agccgtcgtt ccttgccatg caatctgccg
    15241 gcctgatagg tagcttcata tctcaattca ccattttcca aattatattc acggtataaa
    15301 ccgtctttac gatcgttctt catataatat tctttctgcc ttaccccact tccgttggca
    15361 aatgagacat ggagtccatc ttcttttcca tccagatagg tttcaatcat cagcgtatcg
    15421 ccgctttcag caaaagtagt ccaacgacca ttcttctttc cattcttata actacccagt
    15481 atacgtggcg agccaaacgt aaacacggac gaatattcac cgtcctgaaa accttcttca
    15541 ttgaaataaa cggtctcata caaatcatat gtacctttca gaaaagtata ctgtttgcct
    15601 acctgcttcc cgtccttgta attatgctct ttccgcaaag taccgtcaga ttcgtacgac
    15661 agttgcttcc cgtgctcttt ccccatccgg aagtttcttt cactttccac ttttccggta
    15721 gtaaagtaac ttttgctcgt accgtccagc ttaccttcct tataggactt ttcttctttc
    15781 agcttaccgt caaacttgga gttaatcttg aagagaccat ccttccgtcc ttctttataa
    15841 cttccttctg ttattaatat attgtctaca tattctttgt atccgccatc atagaaacca
    15901 tctttaaaag atgccagcac ataggcggaa tgataaccat ctatgatgcg atgttcgcca
    15961 ttcaatgctt tttccgtttt cagttcctga aacaacagtc tgccatcgcc tacattgaca
    16021 acggatacct gatcgatctt atattccttt tgcgcaaaca aaggaagagc aagatataaa
    16081 aacaaaaata cgttccagct ttttgatctg aggaagtttg aaatgtgttt cataaagtag
    16141 ttttctcttt ttgatttatt atttaaagac ctgccgcaaa gataggcaat cggcttataa
    16201 aacaaggaaa gaaagagggg gacaattaga gaaaagaaca tctgttatta tcattctaat
    16261 aattaacaga ttaagtagta aatcaaaaca cagggaaggg ggatatttac tgaaataaga
    16321 aacagaaaag aagatgtgtc aaaagtaact aaatttccct ccttcaggaa ggaggggtgg
    16381 ctgaaagccg gggtggtagg tatatttcac agttgaatat caatagctta tgtattcacc
    16441 taccacctcc ccctacgagt actcctcctt cccgaaggag gagagtttag ttacttttga
    16501 cacacctgct ttttgtattt aaagagattc tacaacaatc tgtctttcag aacaaccgga
    16561 agttcgggca ttgcaccgct c
//
