LOCUS       gnlProkkaBDOOIJMO_111  10771 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BDOOIJMO_111.
ACCESSION   gnlProkkaBDOOIJMO_111
VERSION     gnlProkkaBDOOIJMO_111
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 11:18:02
            Original ID  :: gnl|Prokka|BDOOIJMO_111
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10771
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..231
                     /locus_tag="ctg111_1"
                     /transl_table=11
                     /translation="MGYSDNARKSKKFIVYMNGQVTKVKGSGKKQIEPGCEIIVPGKAK
                     KKGNIANILGYATSFSSLGMMIASIANLIKK"
     protocluster    1..10771
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[1457:5771]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1458..5771
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..10771
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10771
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             246..1394
                     /locus_tag="ctg111_2"
                     /transl_table=11
                     /translation="MSEQRQDKNLLSEPHKTESDEIEIDLVDIFRKIIAIRKKLYKAVG
                     IGFIIGIIVAVSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVLFGKSLLASLRKELKNKEIEQDK"
     CDS             1458..2177
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 56.8; E-value:
                     3.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg111_3"
                     /sec_met_domain="NTP_transf_3 (E-value: 4.2e-17, bitscore:
                     52.9, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CGIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLIAPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             2198..3499
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 209;
                     E-value: 1.4e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg111_4"
                     /sec_met_domain="CTP_transf_like (E-value: 2.3e-13,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 9.7e-122, bitscore:
                     395.5, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.2e-63, bitscore:
                     204.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKAGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKTILENERALEVRELCMPIKEILELIPGTK"
     CDS             3516..4640
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg111_5"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.3e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.1e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             4650..5771
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg111_6_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg111_6"
                     /sec_met_domain="Aminotran_5 (E-value: 1.8e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        4740..5747
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg111_6_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg111_6_Aminotran_5.1"
                     /locus_tag="ctg111_6"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             5768..6241
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156:Chloramphenicol acetyltransferase (Score: 73.7;
                     E-value: 2.7e-22)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg111_7"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYSNIY
                     LGKNAEIRSGCYLIARDKIIIGENSTLAYGTTILTTADPNGPYNALAVLYPYKKAPVVI
                     GDNVWIGANVTILPGVTIGDYVVVAAGAVVTKDVPSGVLVAGVPAIVKKRFNK"
     CDS             6238..7683
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg111_8"
                     /sec_met_domain="Polysacc_synt (E-value: 9.6e-33, bitscore:
                     103.7, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEKTSLKNKAICGIFWSAVERFLSQGIQFVVTVIMARFLLPSDY
                     GMVGMLAIVLQLSQTLMDSGFTNALIRYKERTEIDYSTVFFFNILASLVIYFLIFFLAP
                     YISWFYKIGQLVEITRILSIVIVLNSFAIIPKTKLIIAVDFKTQSKVSFIAALVSGIIG
                     IWAAYLDFGVWALVGQTLVNGLLIVVLYAYFCRWKPLWIFSLKSFRLLFAFGSKLVLAN
                     ILNTLYKNLYAIVIGKKFSSVDLGFYTRAEQFAQFPSYNLSAIISRVTYPILSLVQNDN
                     DRLSALYRKYVRLSSAFIFPLMILLIVIAQPLVLLLLTEKWIGVVVLLQILCLDWMFDH
                     LSSINLNLLYVKGRSDLALRLEVIKKVLATGILLLSIPWGIVGMCWGRVMYSLIAVYLN
                     TYYTESLIKLSLIRQMRDILPSFFLALIMGGGTWYMILLLEGEIVQIVVGSVIALLLYG
                     TLLYCFSRSLFDEIWAVILKIKR"
     CDS             7683..8405
                     /locus_tag="ctg111_9"
                     /transl_table=11
                     /translation="MDKLSLIISKIRRNHWYRTYMRPIYLFVYGNRKLKNRNRIFLQYS
                     QELLTNFHQAMNEVGIPYWLEFGTLLGAVREHSFISHDFDLDVGLFKEDYSDIIREVLK
                     KYGFKRIRCITALDFIDAYEETYLYKGVTIDLFLFSREKNCDGVYCYDFVPVYSDIKRT
                     KKGDNAIRRIHFPRIDLIEYSFIGINTFVPENYEEHLCMHYGKDYMIPNPHWKDSDAQH
                     TDIFYGREIRIELFDKSK"
     CDS             8419..9432
                     /locus_tag="ctg111_10"
                     /transl_table=11
                     /translation="MFYLFFLLIVLFLLYIQSRKRQYSTVAGICVPIIIIFVVICRYRV
                     GYDYLTYYTLIENEEEAQILYLFSPLSIVWAEIALYFESPQMLFVLFGLPTFALLIFTL
                     KKYSKDYALSVTILICFFFFTSLSIIRQALALAICFYGYRLIVKRSLIKYILCILIAAL
                     FHPSAGVAIIIYWLPFLKFRLVVLLSIISIVAKPLFFYMLNILGVYTSYLDGKMDIEGG
                     KYTQLIYFLLFIICFVLGSKNIDKNKCNLFNVLLLSFVFVSFLGAHLGGRIAFYFNIYY
                     CLLIPKVVKGLDGQLREQVKLLSYFLCISYFLLYLFVPFIKGVPSYYIPYKFIFFK"
     CDS             9437..10396
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123:polyprenol-monophosphomannose synthase ppm1
                     (Score: 57.2; E-value: 3.2e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg111_11"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.2e-42,
                     bitscore: 135.7, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLISIIVPCYNSERYLSDCLLSILNQTYVNWEVICIDDGSQDNTL
                     SILNHYATLDERFKIISQSNAGVSVARNKALSQCQGEYICFVDSDDLIEPNFLITLLQL
                     ISHQADLAICGFTRSMVFCMDDAQGYIEMSGKRCIERIILDKSFNPQICCMLFRHNIIK
                     EKQLEFVIGCTRGEDREFILKYLVYSNKVCYTNNLLYHYRVNDQSAMAIFSIKSLTSIE
                     ASQRTVNYYKKVNYSVRGLEFEFSRTLWKFMILAILSGQNDLYQIIREKYDLKRQMEHL
                     YSHPGLSEKLTARLFVWNEALFKWVFSIIRYLYKKRWR"
ORIGIN
        1 ggtggctatt ctgataatgc aaggaagagt aagaagttca ttgtttacat gaatggtcag
       61 gtgacgaagg ttaagggtag tggtaagaaa cagattgagc cggggtgtga gattattgtg
      121 cctggtaagg ctaagaagaa agggaacata gctaatattt taggttatgc tacttccttc
      181 agttctttgg gtatgatgat tgcttctatt gctaatctta taaagaaata atagaattta
      241 cttttatgtc agaacaacga caggataaaa acttgctctc tgaaccacac aagacagaaa
      301 gtgatgagat agaaattgat ttggtcgata tctttcgcaa gattattgct attcgtaaaa
      361 aattatacaa agccgttgga attggtttta ttattggaat aattgtagcg gtaagtatcc
      421 ctaaacagta tacagtaaag gttacccttt ctcctgaaat gggtaatgcg aaggggagta
      481 atggtttagc cggacttgct gcctcgtttt taggagatgg ggctctaata ggggaaagca
      541 cagatgcctt gaacgcttct ctttcagcag atattgtttc ttcaactcct tttttattgg
      601 aacttttaga aatggaagtc tccgtttcta aaaaggatga taaaatgact ttggggtctt
      661 atctcgatga agagtcatct ccttggtggg attatcttat aggttttccg ggcatagtaa
      721 taggaggagt taaatcatta ttcggagaag atacggttcc tgccagtgga gggcggcaag
      781 gaactatcga attgacgaaa gaagtaaatg agaagattaa ttttcttaaa aagaagatta
      841 gtgcatccat tgataagaaa accgccataa cgagcattac ggtcacctta caaaatccgc
      901 agatcactgc ggttatagca gattctgtcg ttcataaatt acaggaatat attattgggt
      961 atcgaacttc aaaagtaaaa gaagactgtg cgtatttgga acggttgttt aaagaacgtc
     1021 agcaggaata ttatgctgct caaagaaaat atgcggatta tgtagacgcc catgataatg
     1081 tggttcttca aagtgtacgt gctgagcagg agcgtttaca gaacgacatg agtttggctt
     1141 atcagatata tagtcaggtt gctaatcagt tgcaggtatc cagagccaaa gtacaggagg
     1201 aaaagccagt ctttgcagta gttgagcctg ccgttgtacc tttgaaacct tcaggtatgg
     1261 gactcaaaat ttatatttta ttatttgtgt tcctgtccgt atctggtact ctcgtgtggg
     1321 tgctttttgg caaaagtctg ctggctagct tgagaaaaga actgaaaaat aaggagatag
     1381 aacaggataa atgatgctaa aacgtcgttt acaacattct tatatcaatt aaattcactt
     1441 actatattat taaacgaatg atacgtacag ctatgataat ggctgcgggc atgggaaccc
     1501 gttttggcca atatacagaa ttgataccta aagggttcgt caaagtggga ggtattccaa
     1561 tgatagttcg ttctattgat actttgttat catgtggcat tgagcgaatt gtaatcggta
     1621 caggatataa acaagaagtt tatgaagaat tgaagacaga ctatcctatg cttgaaacct
     1681 gttttagtcc tcgttatgct gaaacaaata gtatgtatac tttatataat acgcgggaga
     1741 ttctgggcaa tgatgatttt ttattgttag agtcagattt gatttttgag aaacaagcaa
     1801 taatgagctt attggagtgt cctgcggcag atgcaatgct aatagctcca gtgacaaagt
     1861 ttcaagatca gtattatgtg gaacatgatg ataattttcg cctttcttca tgttctgtca
     1921 ataagaataa actaaacgct aaaggcgaat tggtcggcat ccataaacta tccggttcct
     1981 tttacaaaat aatgtgtgct gattatgcga gtattgttga tgaacaaccc aatttgggat
     2041 atgagtatga attactacga atatcttgtt ctcaatctcc tgtttatgtg cataaagtag
     2101 aagggctgaa atggtatgaa atcgatgaca tatcagattt ggaatatgca gagaaatata
     2161 ttgttccgta ttgttaatta aaataatata tcaaattatg agtaagacag tttatattgg
     2221 gatgactgcg gatattatgc atccaggact tatccgcatt attaatgagg ctactaaata
     2281 cggtgatgtt ataattggtc ttcttacaga taaagctatt gcggagcata aacgccttcc
     2341 ttatctgacc tatgaacaac gaaaagaggt agttcagaat attaaaggcg tatgtaaagt
     2401 tgttcctcaa gaagaatgga gctatgttga gaatctcaaa cgcattaaac ctgactatat
     2461 aattcatggt gacgactgga aaaccgggcc tttacgtgaa gaacgtgtgc gcgtatttga
     2521 agtgatgaat gaacagggag gaaaggttat cgaaattcca tatactttgg gaattaattc
     2581 atcttctttg gataaagata ttaaggctat aggtacaacc cccgatgtac gtttaaaatc
     2641 acttcgtcgt ttgataaatg ccaaacccgt agttcgtatt ttggaagctc atgatggact
     2701 atgtggcttg ataattgaaa atcaggaaat attaaaaggg gataagaggg aagtatttga
     2761 cggaatgtgg tctagtagcc ttacggattc aaccagtaaa ggtaaacctg atattgaggc
     2821 ggttgattta actacccgat tgcaagattt gaataatatt ctggagtgta ctactaaacc
     2881 tattattttt gatggagata caggtggtaa aattgaacat ttcgtattta cagtacgcac
     2941 tttagaacgt catggaatct cagctataat aattgaagat aaagttggat taaaaaagaa
     3001 ttcattgttt ggtacggatg ttattcaaac tcaagataca atcgaaggtt tctgtaataa
     3061 gatcaaagca ggaaaggcat ctcagattac tgatgatttt atgattatcg ctcgtattga
     3121 gagccttata gcgggaaagc cggtaagtga tgctttagag agagcttttg catatgtcca
     3181 agcgggagcg gacggtatta tgatacatag caaaaataag tcgggtgaag atataaaaga
     3241 attttgtttg gcgtttcgaa aacagtatgc tcatgtacct atcgtggttg tgcctactac
     3301 atatgatcat atttatgagt ctgaattgtg tgattggggt gtgaatataa ttatttatgc
     3361 taatcatatg cttcgtgccg cttatcctgc tatgatgaat gtcgcaaaga caatattaga
     3421 gaatgaacgt gctttagagg tgcgcgaact gtgtatgccc ataaaggaaa tattggaact
     3481 gattccgggt actaaataaa aagaggaata tcattatgtt aagcgtagaa aaagtttatg
     3541 aaacgtttct gagtcatgac gttgattttt ttacaggagt tccagactca ttactaaaaa
     3601 atatttgtgc ctatatcaca gaccatactt cacgtgagaa acatatcata gctgctaatg
     3661 aaggtgcggc tgtaggaatt gcttcaggtt attatatggc atcaggtaag gttcctgtgg
     3721 tttatatgca aaattccggc ttgggtaata ctgttaatcc tctgctgtct cttgcagatg
     3781 aacaagtata cagttttcca atgcttttga tgattggctg gcgtggtgaa ccgggaacaa
     3841 aagatgaacc tcagcataaa aaacagggtg aggtaacttt agatttgttg aaagcaatgc
     3901 ggattcctta tataattctt gattcaaatg agaatgatgc atttattcag ctccatgata
     3961 tcatacaatc agcaaaaact aagaatattc ctcatgcaat aattattcgg aaagatgttt
     4021 ttggcaaata taaacttcaa aaagagttcg gatgtaatta tcctttatct cgtgaggatg
     4081 ctttgcaaat agttgtggat tatctgcctg aaaattcagt ggtcgtttct actactggca
     4141 agctttctcg tgagttattt gaatatcgag aaatgaaaga gcaaggtcat gaacatgatt
     4201 ttctcacggt aggctctatg ggacatagtt catcaatctc tttgggtatt gctatagcaa
     4261 agcaagatag acctgtttat tgcttggatg gtgatggagc atttattatg catttagggg
     4321 caattagtaa cattggcgat ttatctccta aaaactatta tcatattttg tttaacaatg
     4381 gtgctcacga gtctgtagga ggacagccta ctttaggatt tagtttagat attccggcta
     4441 ttgtccgggg gagcggatat aagcatactt atactgtttg tacaaaagtt gaaattgaag
     4501 aagcaatgaa gcagcttcca aagttatgtg gtcctgtttt gttggaaata aaggttaaaa
     4561 tagattctcg ggagaatttg ggacgtccca cgactactcc tatagagaat aaggagcatt
     4621 ttatggattt tttaaaataa atatattcga tgaaaataga aagaaaaata ttattaaatc
     4681 ctgggcctgc cactactact gacagtgtaa aaatggcaca agttgttccg gatatttgtc
     4741 ctcgcgagaa agaattcgca ggtatgatga aacaacttcg ggacgatttg gtcagagttg
     4801 ctcatgggaa tttggaaaaa cataccgctg tattattttg tggctcagga accatcaata
     4861 ttgatatatg tctaaattct cttcttcctg aagacaaaag ggtgcttata gtgaataatg
     4921 gggcatatag tacccgtgct gtagaagtgt gtcaatatta tggtttgcct catattaatt
     4981 tggaattttc cgtttacgaa cgtcctgatt tatcggtggt ggaaaatgtg ttgcaagaaa
     5041 atcctgatat agctatggtt tatactactc atcacgagac gggtacagga attctgaacc
     5101 ctattcgcga gatgggcgct atagctcata aatatcaggc taaatttgtc gtcgatacta
     5161 cttcttcttt gggcatgatt ccttttgata tagagaaaga taatgtggat ttttgtatgg
     5221 catctgctca aaaaggactt caagcgatga caggtctttc ttttattata ggcaatgagg
     5281 aacagattaa gttttcaaaa aaatatccca agcgttctta ctattgtaat ctttatttgc
     5341 agtatgagaa ttttgagaga acaggtgaaa tgcattttac tccaccggta caaactattt
     5401 acgccactcg tcaggcatta aatgaatatt ttgaagtggg cgaagaagct aagtttgccc
     5461 gtcacaaaag agtttttgag gctattcatt caggtataaa tgaaattggt cttaaaagtg
     5521 taataaagcg tgaatggcag tcaggactgg ttgtctcagt tcaataccca gaagatccca
     5581 actgggattt tgagaaaata catgattatt gttatgagcg tggatttacg atttatccag
     5641 gtaagatatc aactgaggat acttttagaa tctgtgcttt aggagagata gaagtagatg
     5701 atattgagaa cttctttaaa gtactaaaag ctgcattaaa tcattataac gtcacattac
     5761 cgatgtcatg attgcagaaa tattattgaa gattcgtcat ttttattttt cccttcgtgg
     5821 tatacacttc catccggaaa gtgttatttc tggagtgcct attcgtagct ttcgcttagt
     5881 aggcaaatat agcaatatct acttaggtaa aaatgctgaa atacgttcag gctgttatct
     5941 gattgctcgt gataaaatca ttattggaga aaactcaaca ctcgcctatg gaacgactat
     6001 attgacaact gctgatccta atggaccgta taatgcatta gcagttcttt atccttataa
     6061 aaaggcaccg gtagttatag gagataatgt ttggattggg gctaatgtta ccatccttcc
     6121 tggagtaact attggtgatt acgttgtagt agcagctgga gctgttgtaa caaaagatgt
     6181 accttcagga gtattggtag ctggtgtacc agctattgtg aaaaaacgtt ttaataaatg
     6241 aaagaaaaaa cttctttaaa gaacaaagcc atatgtggaa tcttttggag tgcagttgaa
     6301 cgatttttat cacaggggat acagtttgta gttacagtca ttatggcgcg ttttctattg
     6361 ccatctgatt atggaatggt aggaatgtta gcaatagttc ttcaattatc tcaaacgtta
     6421 atggatagtg gttttactaa tgcccttatt cgttataagg aacgtactga aattgattat
     6481 tcaacagttt tcttttttaa tatattagca tcattagtta tttattttct aatttttttt
     6541 ctagctcctt atatatcgtg gttttataaa ataggtcaat tagttgagat tactagaatt
     6601 ttatctattg ttattgtttt aaattccttt gcgattattc ctaaaactaa attaataata
     6661 gctgtagatt ttaaaactca atcaaaagtc tcatttattg cagctttggt ttcaggtatt
     6721 attggcattt gggctgcata tttagatttt ggagtttggg ctttagttgg acaaacttta
     6781 gtaaacggat tgttgattgt agttttgtat gcatattttt gtagatggaa accattgtgg
     6841 atattttcat tgaaatcgtt tcgtttatta tttgcttttg ggtcaaaatt agtattagct
     6901 aatattctta atactttata taaaaatctg tatgctatag ttataggaaa gaagttttcg
     6961 tcggttgatt taggatttta tactcgtgcg gaacaatttg ctcagtttcc ttcatataat
     7021 ttgagtgcaa taatttctag agtgacatac cccatattga gccttgtgca aaatgataat
     7081 gatagattat ctgctttata taggaaatat gtccgtttat cttctgcttt tatctttcca
     7141 ttgatgattt tgttaattgt catagctcag ccactggtat tattgctttt gacagaaaaa
     7201 tggataggag tagttgtatt gcttcaaata ttgtgtttag attggatgtt tgatcatttg
     7261 agtagtataa atttgaattt actatatgta aagggacgtt cagacttggc tttacgttta
     7321 gaagttataa aaaaagtgtt agcgacgggg atccttcttc tatctattcc ttgggggatt
     7381 gtaggtatgt gttgggggcg tgttatgtat tcattgattg ctgtgtattt gaatacttat
     7441 tatacagaat cattgattaa attaagtctt attagacaga tgagagatat actaccaagc
     7501 ttttttttag cattaataat gggaggaggt acttggtata tgattttatt gttagagggt
     7561 gaaattgttc aaattgtagt aggaagtgtt attgctttat tgctatatgg aacgttgttg
     7621 tattgctttt ctcgatcctt gtttgatgaa atatgggcgg ttatattaaa aataaaaagg
     7681 taatggataa actgagtttg attattagta aaatacgacg gaatcattgg tatagaacct
     7741 atatgcgtcc tatatattta tttgtttatg gcaatagaaa attgaagaat agaaatagaa
     7801 tatttttgca gtattcacaa gagctgctaa ctaactttca tcaagcaatg aatgaagtgg
     7861 gaattcctta ttggttagaa tttggaactc ttttaggtgc tgttagagaa cacagtttta
     7921 taagtcatga ttttgatctt gatgtgggcc tttttaagga agattattca gatataataa
     7981 gagaggtctt aaaaaaatat ggtttcaaaa gaataaggtg tataaccgcc cttgatttta
     8041 ttgatgctta tgaggaaact tatctttata aaggtgtgac aattgatctt ttcctttttt
     8101 caagagagaa aaattgtgat ggggtctatt gttatgattt tgttccagta tattcagata
     8161 taaagagaac taaaaaaggt gataatgcaa tccggagaat tcattttcct agaattgatt
     8221 tgattgaata ttcatttatt ggaattaata cttttgttcc tgaaaattat gaggaacatc
     8281 tttgtatgca ttatggtaaa gactatatga ttccaaatcc tcattggaaa gattcagatg
     8341 cgcaacatac tgatatcttt tatggtagag agattagaat tgaattgttt gataaaagta
     8401 aataatagta gataatacat gttctatcta ttttttttac taattgtgct atttttgtta
     8461 tatatacaaa gtaggaaaag acaatattct actgtagcgg gaatttgtgt tcctattatt
     8521 ataatttttg ttgtaatttg tcgttataga gtggggtatg actatttaac gtattataca
     8581 ttaattgaaa atgaagaaga ggcacagatt ttatacttat tttctccttt aagcattgtt
     8641 tgggcagaga ttgctttata ttttgaatct ccacagatgt tatttgttct ttttgggctt
     8701 ccaacatttg ctcttctaat atttacttta aaaaaatatt caaaagatta tgcgttatca
     8761 gtaactattt taatttgttt cttctttttt acatcactca gtattattcg acaagctttg
     8821 gctttggcta tttgttttta tggttatcgt cttatagtaa aacgttcact aattaaatat
     8881 atattatgta tattgattgc agctttattc catccttctg caggagtagc gattattata
     8941 tattggttgc catttctaaa gtttagatta gttgtattat tatctataat atcaatagta
     9001 gccaaacctt tattttttta tatgctaaat atattagggg tgtatacctc ttatcttgat
     9061 ggcaagatgg atattgaagg tgggaaatat actcaattaa tatacttttt gttgtttatt
     9121 atttgttttg ttttgggaag taaaaacata gataaaaaca agtgtaattt atttaatgtt
     9181 ttattgttaa gttttgtttt cgtatctttt ttaggagctc atttaggcgg gagaatagcg
     9241 ttttatttta atatatatta ttgtttgttg attcctaaag tggttaaagg attggatggg
     9301 caactaagag agcaagtgaa gcttctttct tattttctat gtatttctta tttcttattg
     9361 tacctattcg ttccattcat aaaaggtgta ccctcatatt atatcccata taagtttata
     9421 tttttcaaat agtaaaatgt tgatatctat aattgtccct tgttataatt ctgaaagata
     9481 tttgtctgat tgtttattgt ctatattgaa tcaaacctat gttaattggg aggtgatttg
     9541 tatagatgat ggaagtcaag ataatacatt atctatttta aatcattacg ctacattgga
     9601 tgagcgtttt aaaattattt ctcagtctaa tgcaggagtg tctgtcgcaa gaaataaggc
     9661 tctatcccag tgtcaaggag agtatatttg ctttgttgat agtgatgacc tgatagaacc
     9721 taattttttg ataacacttt tacagcttat aagtcatcag gctgatttgg caatctgtgg
     9781 ttttactcgt tctatggttt tctgtatgga tgatgctcaa ggatatatag aaatgagtgg
     9841 taaacgttgt atagaaagaa ttattctaga taaaagtttc aatcctcaga tttgttgtat
     9901 gttatttcga cataatatta taaaagagaa acaattagaa tttgtgatag ggtgtactcg
     9961 tggtgaagat cgtgaattta tattgaaata tttagtttat tctaataagg tttgttatac
    10021 aaacaatctt ctttatcact atcgtgtaaa tgatcagtca gccatggcaa tcttttctat
    10081 taaaagtttg acaagtatag aagcttcaca acgcacggtc aactactata aaaaagtgaa
    10141 ttattctgtt agagggcttg aatttgaatt ttcacgtaca ttgtggaaat tcatgatttt
    10201 agctattttg tctgggcaaa atgatttata tcaaatcatt cgagaaaagt atgatctaaa
    10261 aagacaaatg gaacatcttt attctcatcc aggactatcc gaaaaactta cagcgagatt
    10321 gtttgtttgg aatgaggcac tttttaaatg ggtattttct attattagat atctatataa
    10381 aaaaagatgg agatgaataa acgaaataga ttatctgaac aagaaataaa aaaagtagaa
    10441 cttgacgctt tattgtatat tcggaaaatt tgtcagcaat atcatcttcg ctattattta
    10501 gcttggggta ctttgttggg agccgttagg cataaaggat ttattccttg ggatgatgat
    10561 attgatataa tgatgccacg ttcagattat gagcgattat tggagttagt tccttccttg
    10621 agacatagtt attataaaat cttaagtaat ccaaagaatg aggattatta ttatactcat
    10681 gcaaaaatga tagatactcg tactttgtgt gtggaaaatg atttgcaaac tattcaaaat
    10741 atggggattt gggttgatat tttcccctta g
//
