LOCUS       gnlProkkaDFJDPHLC_54   11741 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DFJDPHLC_54.
ACCESSION   gnlProkkaDFJDPHLC_54
VERSION     gnlProkkaDFJDPHLC_54
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 10:53:39
            Original ID  :: gnl|Prokka|DFJDPHLC_54
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11741
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11741
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[2427:6741]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2428..6741
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..11741
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11741
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             3..1205
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 58;
                     E-value: 1.1e-17)"
                     /gene_kind="transport"
                     /locus_tag="ctg54_1"
                     /transl_table=11
                     /translation="MYQLSGKLNTIRELVHEAQGLTGDAFLNRAVLYRQREDLTSEVVQ
                     IDIKSIMDGTSPNLALMKNDILYIPSIHDLEDRGNVTVHGEVAQPDSYPYADNMTLEDL
                     IIQAGGLKEAASTVRIDISRRIKNPRSTADNDTIGQMYTFSLKDGFVIDGQPGFILEPY
                     DQVYVRRSPGYQAQQNVAIEGEILFGGNYAMTSREERLSDLVNKAGGPTNYAYLRGAKL
                     TRVANASEKKRMGDVIRLMSRQLGEAMIDSLGIRVEDTFTVGIDLEKALSNPKSNADLV
                     LREGDVISIPKNTNTVTINGAVMVPNTVSYMKGKNVDYYLNQAGGCSDNARKSKKFIVY
                     MNGQVTKVKGSGKKQIEPGCEIIVPGKAKKKGNIANILGYATSFSSLGMMIASIANLIK
                     K"
     CDS             1216..2364
                     /locus_tag="ctg54_2"
                     /transl_table=11
                     /translation="MIEKQSYQEPFSEVDKRKDDEMEIDLMAIFYKIITVRGVLCKAAG
                     VGVIIAIVVALSIPKQYTVKVTLSPEMGNAKGSNGLAGLAASFLGDGALIGESTDALNA
                     SLSADIVSSTPFLLELLEMEVSVSKKDDKMTLGSYLDEESSPWWDYLIGFPGIVIGGVK
                     SLFGEDTVPASGGRQGTIELTKEVNEKINFLKKKISASIDKKTAITSITVTLQNPQITA
                     VIADSVVHKLQEYIIGYRTSKVKEDCAYLERLFKERQQEYYAAQRKYADYVDAHDNVVL
                     QSVRAEQERLQNDMSLAYQIYSQVANQLQVSRAKVQEEKPVFAVVEPAVVPLKPSGMGL
                     KIYILLFVFLSVSGTLVWVLFGKSLLASLRKELKNKEIEQDK"
     CDS             2428..3147
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 56.8; E-value:
                     3.3e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg54_3"
                     /sec_met_domain="NTP_transf_3 (E-value: 6.8e-17, bitscore:
                     52.2, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRTAMIMAAGMGTRFGQYTELIPKGFVKVGGIPMIVRSIDTLLS
                     CGIERIVIGTGYKQEVYEELKTDYPMLETCFSPRYAETNSMYTLYNTREILGNDDFLLL
                     ESDLIFEKQAIMSLLECPAADAMLITPVTKFQDQYYVEHDDNFRLSSCSVNKNKLNAKG
                     ELVGIHKLSGSFYKIMCADYASIVDEQPNLGYEYELLRISCSQSPVYVHKVEGLKWYEI
                     DDISDLEYAEKYIVPYC"
     CDS             3168..4469
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 207.4;
                     E-value: 4.4e-63)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg54_4"
                     /sec_met_domain="CTP_transf_like (E-value: 2.3e-13,
                     bitscore: 40.6, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 6.1e-121, bitscore:
                     392.9, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 2.9e-63, bitscore:
                     203.5, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKTVYIGMTADIMHPGLIRIINEATKYGDVIIGLLTDKAIAEHK
                     RLPYLTYEQRKEVVQNIKGVCKVVPQEEWSYVENLKRIKPDYIIHGDDWKTGPLREERV
                     RVFEVMNEQGGKVIEIPYTLGINSSSLDKDIKAIGTTPDVRLKSLRRLINAKPVVRILE
                     AHDGLCGLIIENQEILKGDKREVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAIIIEDKVGLKKNSLFGTDVIQTQDT
                     IEGFCNKIKEGKASQITDDFMIIARIESLIAGKPVSDALERAFAYVQAGADGIMIHSKN
                     KSGEDIKEFCLAFRKQYAHVPIVVVPTTYDHIYESELCDWGVNIIIYANHMLRAAYPAM
                     MNVAKTILENERALEVRELCMPIKEILELIPGTK"
     CDS             4486..5610
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.1;
                     E-value: 1.1e-17)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg54_5"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.3e-20, bitscore:
                     63.7, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.1e-20, bitscore:
                     64.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSVEKVYETFLSHDVDFFTGVPDSLLKNICAYITDHTSREKHII
                     AANEGAAVGIASGYYMASGKVPVVYMQNSGLGNTVNPLLSLADEQVYSFPMLLMIGWRG
                     EPGTKDEPQHKKQGEVTLDLLKAMRIPYIILDSNENDAFIQLHDIIQSAKTKNIPHAII
                     IRKDVFGKYKLQKEFGCNYPLSREDALQIVVDYLPENSVVVSTTGKLSRELFEYREMKE
                     QGHEHDFLTVGSMGHSSSISLGIAIAKQDRPVYCLDGDGAFIMHLGAISNIGDLSPKNY
                     YHILFNNGAHESVGGQPTLGFSLDIPAIVRGSGYKHTYTVCTKVEIEEAMKQLPKLCGP
                     VLLEIKVKIDSRENLGRPTTTPIENKEHFMDFLK"
     CDS             5620..6741
                     /NRPS_PKS="Domain: Aminotran_5 (30-366). E-value: 2.9e-34.
                     Score: 110.4. Matches aSDomain:
                     nrpspksdomains_ctg54_6_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 76.3; E-value:
                     3.6e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg54_6"
                     /sec_met_domain="Aminotran_5 (E-value: 1.8e-31, bitscore:
                     99.3, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIERKILLNPGPATTTDSVKMAQVVPDICPREKEFAGMMKQLRD
                     DLVRVAHGNLEKHTAVLFCGSGTINIDICLNSLLPEDKRVLIVNNGAYSTRAVEVCQYY
                     GLPHINLEFSVYERPDLSVVENVLQENPDIAMVYTTHHETGTGILNPIREMGAIAHKYQ
                     AKFVVDTTSSLGMIPFDIEKDNVDFCMASAQKGLQAMTGLSFIIGNEEQIKFSKKYPKR
                     SYYCNLYLQYENFERTGEMHFTPPVQTIYATRQALNEYFEVGEEAKFARHKRVFEAIHS
                     GINEIGLKSVIKREWQSGLVVSVQYPEDPNWDFEKIHDYCYERGFTIYPGKISTEDTFR
                     ICALGEIEVDDIENFFKVLKAALNHYNVTLPMS"
     aSDomain        5710..6717
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg54_6_Aminotran_5.1"
                     /evalue="2.90E-34"
                     /label="ctg54_6_Aminotran_5.1"
                     /locus_tag="ctg54_6"
                     /protein_end="366"
                     /protein_start="30"
                     /score="110.4"
                     /tool="antismash"
                     /translation="PREKEFAGMMKQLRDDLVRVAHGNLEKHTAVLFCGSGTINIDICL
                     NSLLPEDKRVLIVNNGAYSTRAVEVCQYYGLPHINLEFSVYERPDLSVVENVLQENPDI
                     AMVYTTHHETGTGILNPIREMGAIAHKYQAKFVVDTTSSLGMIPFDIEKDNVDFCMASA
                     QKGLQAMTGLSFIIGNEEQIKFSKKYPKRSYYCNLYLQYENFERTGEMHFTPPVQTIYA
                     TRQALNEYFEVGEEAKFARHKRVFEAIHSGINEIGLKSVIKREWQSGLVVSVQYPEDPN
                     WDFEKIHDYCYERGFTIYPGKISTEDTFRICALGEIEVDDIENFFKVLKAALNHY"
     CDS             6738..7214
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156:Chloramphenicol acetyltransferase (Score: 70.3;
                     E-value: 2.9e-21)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg54_7"
                     /transl_table=11
                     /translation="MIAEILLKIRHFYFSLRGIHFHPESVISGVPIRSFRLVGKYSNIY
                     LGKNAEIRSGCYLIARDKIIIGENSTLAYGTTILTTADPNGPYNALAILYPYKKAPVVI
                     GDNVWIGANVTILPGITIGDYVVVAAGSVVTKDVPSGVLVAGVPAVVKKQLLME"
     CDS             7283..8104
                     /locus_tag="ctg54_8"
                     /transl_table=11
                     /translation="MKDKTCHIITDDNIKEIELSILKYIDLQCKKYNLRYYLGYGTLLG
                     AVRHQGFIPWDDDIDIWMPREDYDKFISLENSLENSKFKILSPLNNSDYYYGFAKLVSR
                     NTELQEIGFLPIKDYGVYVDIFPLDNIATEHPFLHFIAKYIIMARIASCNIKPWLNLTH
                     KKKAILFRFIGIIGTLLGFRRTAKLTDKIAKIDKGKTNKRVGVFVESIGEHNIFATEYF
                     ASTIQLKFEGIYFNAPKEYRKCLTQLYGDYMQLPPENRRISGHSFKACYRL"
     CDS             8089..8847
                     /locus_tag="ctg54_9"
                     /transl_table=11
                     /translation="MLQIMKLTTYVLNLLKDKERKEYMQYVLSDYPNLDIQYVNAINGK
                     NLSLDEILNQFDNNKAYKRYGRECDLGEIGCSLSHRLAFDLLMNSESNYALILEDDIVI
                     GDGFSSVLEKLLPLIDIDAPCVILLSGGVSYYKKRYYNTLCLGVVYMGDYAHSYLINKA
                     AAKLILDDKKAYIFADDWDYIRNRGVNVLVILPHLVDQRRDGSFVSNVWQDNHHIVKVK
                     LSLIRLCNYILSRIIDKILKRMGNYENKTL"
     CDS             8849..10384
                     /locus_tag="ctg54_10"
                     /transl_table=11
                     /translation="MVESRSKKGIANIKCSLFFYIVNLFLNIISRKVFIDYLGIEVLGL
                     NTTVTNLLSFLNLAELGIGNAIAFTLYKPLFLKDFQVIREIVSVQAWLYRRIAYFISIG
                     ALGLMLLFPVIFKKIDLPLWYAYATFIVLLIASLLSYFVNYKQILLSADQKEYKITLCV
                     QGIKSLKTITQVVVILYLINGYVYWLTLELVGVLVSALLLNKIVNKEYPWLFVKVSDGK
                     KLRNKYPEIIVKTKQFFFHRISSFVLNQTSPLIIYAFASLTMVAIYGNYMLIVFGGIAL
                     VNAFFNGFNAGVGNLVAEGDKKKIKSFFWEITSFRIWIAAIICVCFFKLCHPFISLWVG
                     KEYVLDEMTFIVLTIYVFISLTRVNEAFLFAYGLYQDIWAPIIEAILNLGLSVLLGFIW
                     GLTGIISGVVISLVVIVCIWKPYFLFKMGFKDNILEYVSRYIKYYMMIALSFILSHLIL
                     NTMFIDFQSSYWKLFEYACTVGSCYAILSFLFFYLFDNGMRQFTRRLLNIFLK"
     CDS             10454..11467
                     /locus_tag="ctg54_11"
                     /transl_table=11
                     /translation="MSFYIFIFVVLLYFSFRKYNKYIYWGTILLLSLIAGLRSETIGVD
                     THAYKDIFIWISNEVLYPIEPAWYFFNKLIAWVGGSFNFLLWITALLTLIPIGVVSLRC
                     SSNPQMSLFFYYGLYAYINSFNGMRQFVAISFVLLAYSYITQKKNFFLYLLIAFIFHYS
                     AIFSFIAILVDKVSLTKRRVIGGIFSSFFVGMFFNDSMFLVLAGPYAGYLESSEGYRDN
                     FLLAAIMAILMSCLYMCTFFTLRREYKQNLWTKMFFVGIIILNITMRLELGARIILYFT
                     LCQIIFYPMYFRHNIVKNKRMVVLSILLYTSLVFMKILILGNQGEYSVYPYKTILW"
ORIGIN
        1 gtatctacca gctcagcggt aaactgaata cgatccgcga acttgtccat gaagcccagg
       61 gcctgaccgg tgacgctttc ctgaatcgtg ccgtccttta tcgccagcgt gaagacctga
      121 ccagtgaagt tgttcagata gacattaagt ctatcatgga cggcacttcc ccaaaccttg
      181 ccctgatgaa gaatgacatc ctctacattc caagtatcca tgacctggaa gaccggggta
      241 atgtcacagt tcacggtgag gttgcccaac ctgattccta tccttatgcg gataacatga
      301 cacttgagga tctgatcatt caggccggtg gcttgaaaga agccgcctct actgtccgta
      361 ttgatatatc gagacgaatc aagaatcctc gtagtactgc ggataatgat acgattggtc
      421 agatgtatac cttctcttta aaggatggtt ttgtaataga tggtcagccc ggttttatcc
      481 ttgagcctta tgatcaggtt tatgtccgtc gcagtccggg ctatcaggca caacagaatg
      541 tagccattga aggtgaaatc cttttcggag gaaattacgc catgaccagc cgtgaggaac
      601 gtctttccga tttagtgaat aaagccggcg gtccgaccaa ttatgcctat ctgcgtggtg
      661 cgaaactgac ccgtgtggct aacgctagtg aaaagaaacg tatgggtgat gtaattcgcc
      721 ttatgagcag gcaattgggc gaagccatga ttgactcttt gggtattcgt gttgaagata
      781 cttttacggt tggaatagat ttggaaaaag ccttgagcaa tcctaaaagt aatgccgatc
      841 ttgtcttacg tgaaggtgat gtgatctcca tacctaagaa tactaatact gtaactatca
      901 atggtgctgt catggttccg aatacggttt cttatatgaa gggaaagaat gtggattatt
      961 acctgaatca ggccggtggc tgttctgata atgcaaggaa gagtaagaag ttcattgttt
     1021 acatgaatgg tcaggtgacg aaggttaagg gtagtggtaa gaaacagatt gagccggggt
     1081 gtgagattat tgtgcctggt aaggctaaga agaaagggaa catagctaat attttaggtt
     1141 atgctacttc cttcagttct ttgggaatga tgattgcttc tattgctaat ttgataaaga
     1201 aataaatgac ctattatgat tgaaaagcaa tcttatcaag aaccgttttc tgaagtggat
     1261 aaaaggaaag atgatgaaat ggaaatagac ttgatggcta ttttttataa gattattact
     1321 gttcgtggag tactatgcaa agctgctgga gtgggagtaa taattgctat agtggtggca
     1381 ttgagcattc ccaagcaata tacagtaaag gttacccttt ctcctgaaat gggtaatgcg
     1441 aagggaagta atggtttagc cggacttgct gcctcgtttt tgggagatgg ggctctaata
     1501 ggggaaagca cagatgcctt gaacgcttct ctttcagcag atattgtttc ttcaactcct
     1561 tttttattgg aacttttaga aatggaagtc tccgtttcta aaaaggatga taaaatgact
     1621 ttggggtctt atctcgatga agagtcatct ccttggtggg attatcttat aggttttccg
     1681 ggcatagtaa taggaggagt taaatcatta ttcggagaag atacggttcc tgccagtgga
     1741 gggcggcaag gaactatcga attgacgaaa gaagtaaatg agaagattaa ttttcttaaa
     1801 aagaagatta gtgcatccat tgataagaaa accgccataa cgagcattac ggtcacctta
     1861 caaaatccgc agatcactgc ggttatagca gattctgtcg ttcataaatt acaggaatat
     1921 attattgggt atcgaacttc aaaagtaaaa gaagactgtg cgtatttgga acggttgttt
     1981 aaagaacgtc agcaggaata ttatgctgct caaagaaaat atgcggatta tgtagacgcc
     2041 catgataatg tggttcttca aagtgtacgt gctgagcagg agcgtttaca gaacgacatg
     2101 agtttggctt atcagatata tagtcaggtt gctaatcagt tgcaggtatc cagagccaaa
     2161 gtacaggagg aaaagccagt ctttgcagta gttgagcctg ccgttgtacc tttgaaacct
     2221 tcaggtatgg gactcaaaat ttatatttta ttatttgtgt tcctgtccgt atctggtact
     2281 ctcgtgtggg tgctttttgg caaaagtctg ctggctagct tgagaaaaga actgaaaaat
     2341 aaggagatag aacaggataa atgatgctaa aacgtcgttt acaacattct tacatcaatt
     2401 aaattcactt actatattat taaacgaatg atacgtacag ctatgataat ggctgcgggc
     2461 atgggaaccc gttttggcca atatacagaa ttgataccta aagggttcgt caaagtggga
     2521 ggtattccaa tgatagttcg ttctattgat actttgttat catgtggcat tgagcgaatt
     2581 gtaatcggta caggatataa acaagaagtt tatgaagaat tgaagacaga ctatcctatg
     2641 cttgaaacct gttttagtcc tcgttatgct gaaacaaata gtatgtatac tttatataat
     2701 acgcgggaga ttctgggcaa tgatgatttt ttattgttag agtcagattt gatttttgag
     2761 aaacaagcaa taatgagctt attggagtgt cctgcggcag atgcaatgct aataactcca
     2821 gtgacaaagt ttcaagatca gtattatgtg gaacatgatg ataattttcg cctttcttca
     2881 tgttctgtca ataagaataa actaaacgct aaaggcgaat tggtcggcat ccataaacta
     2941 tccggttcct tttacaaaat aatgtgtgct gattatgcga gtattgttga tgaacaaccc
     3001 aatttgggat atgagtatga attactacga atatcttgtt ctcaatctcc tgtttatgtg
     3061 cataaagtag aagggctgaa atggtatgaa atcgatgaca tatcagattt ggaatatgca
     3121 gagaaatata ttgttccgta ttgttaatta aaataatata tcaaattatg agtaagacag
     3181 tttatattgg gatgactgcg gatattatgc atccaggact tatccgcatt attaatgagg
     3241 ctactaaata cggtgatgtt ataattggtc ttcttacaga taaagctatt gcggagcata
     3301 aacgccttcc ttatctgacc tatgaacaac gaaaagaggt agttcagaat attaaaggcg
     3361 tatgtaaagt tgttcctcaa gaagaatgga gctatgttga gaatctcaaa cgcattaaac
     3421 ctgactatat aattcatggt gacgactgga aaaccgggcc tttacgtgaa gaacgtgtgc
     3481 gcgtatttga agtgatgaat gaacagggag gaaaggttat cgaaattcca tatactttgg
     3541 gaattaattc atcttctttg gataaagata ttaaggctat aggtacaacc cctgatgtac
     3601 gtttaaaatc acttcgtcgt ttgataaatg ccaaacccgt agttcgtatt ttggaagctc
     3661 atgatggact atgtggcttg ataattgaaa atcaggaaat attaaaaggg gataagaggg
     3721 aagtatttga cggaatgtgg tctagtagcc ttacggattc aaccagtaaa ggtaaacctg
     3781 atattgaggc ggttgattta actacccgat tgcaagattt gaataatatt ctggagtgta
     3841 ctactaaacc tattattttt gatggagata caggtggtaa aattgaacat ttcgtattta
     3901 cagtacgcac tttagaacgt catggaattt cagctataat aattgaagat aaagttggat
     3961 taaaaaagaa ttcattgttt ggtacagatg ttattcaaac tcaagataca atcgaaggtt
     4021 tctgtaataa gatcaaagaa ggaaaggcat ctcagattac tgatgatttt atgattatcg
     4081 ctcgtattga gagccttata gcgggaaagc cggtaagtga tgctttagag agagcttttg
     4141 catatgtcca agcgggagcg gacggtatta tgatacatag caaaaataag tcgggtgaag
     4201 atataaaaga attttgtttg gcgtttcgaa aacagtatgc tcatgtacct atcgtggttg
     4261 tgcctactac atatgatcat atttatgagt ctgaattgtg tgattggggt gtgaatataa
     4321 ttatttatgc taatcatatg cttcgtgccg cttatcctgc tatgatgaat gtcgcaaaga
     4381 caatattaga gaatgaacgt gctttagagg tgcgcgaact gtgtatgccc ataaaagaaa
     4441 tattggaact gattccaggt actaaataaa aagaggaata tcattatgtt aagcgtagaa
     4501 aaagtttatg aaacgtttct gagtcatgac gttgattttt ttacaggagt tccagactca
     4561 ttactaaaaa atatttgtgc ctatatcaca gaccatactt cacgtgagaa acatatcata
     4621 gctgctaatg aaggtgcggc tgtaggaatt gcttcaggtt attatatggc atcaggtaag
     4681 gttcctgtgg tttatatgca aaattccggc ttgggtaata ctgttaatcc tctgctgtct
     4741 cttgcagatg aacaagtata cagttttcca atgcttttga tgattggctg gcgtggtgaa
     4801 ccgggaacaa aagatgaacc tcagcataaa aaacagggtg aggtaacttt agatttgttg
     4861 aaagcaatgc ggattcctta tataattctt gattcaaatg agaatgatgc atttattcag
     4921 ctccatgata tcatacaatc agcaaaaact aagaatattc ctcatgcaat aattattcgg
     4981 aaagatgttt ttggcaaata taaacttcaa aaagagtttg gatgtaatta tcctttatct
     5041 cgtgaggatg ctttgcaaat agttgtggat tatctgcctg aaaattcagt ggtcgtttct
     5101 actactggca agctttctcg tgagttattt gaatatcgag aaatgaaaga gcaaggtcat
     5161 gaacatgatt ttctcacggt aggctctatg ggacatagtt catcaatctc tttgggtatt
     5221 gctatagcaa agcaagatag acctgtttat tgcttggatg gtgatggagc atttattatg
     5281 catttagggg caattagtaa cattggcgat ttatctccta aaaactatta tcatattttg
     5341 tttaacaatg gtgctcacga gtctgtagga ggacagccta ctttaggatt tagtttagat
     5401 attccggcta ttgtccgggg gagcggatat aagcatactt atactgtttg tacaaaagtt
     5461 gaaattgaag aagcaatgaa gcagcttcca aagttatgtg gtcctgtttt gttggaaata
     5521 aaggttaaaa tagattctcg ggagaatttg ggacgtccca cgactactcc tatagagaat
     5581 aaggagcatt ttatggattt tttaaaataa atatattcga tgaaaataga aagaaaaata
     5641 ttattaaatc ctgggcctgc cactactact gacagtgtaa aaatggcaca agttgttccg
     5701 gatatttgtc ctcgcgagaa agaattcgca ggtatgatga aacaacttcg ggacgatttg
     5761 gtcagagttg ctcatgggaa tttggaaaaa cataccgctg tattattttg tggctcagga
     5821 accatcaata ttgatatatg tctaaattct cttcttcctg aagacaaaag ggtgcttata
     5881 gtgaataatg gggcatatag tacccgtgct gtagaagtgt gtcaatatta tggtttgcct
     5941 catattaatt tggaattttc cgtttatgaa cgtcctgatt tatcggtggt ggaaaatgtg
     6001 ttgcaagaaa atcctgatat agctatggtt tatactactc atcacgagac gggtacagga
     6061 attctgaacc ctattcgcga gatgggcgct atagctcata aatatcaggc taaatttgtc
     6121 gtcgatacta cttcttcttt gggcatgatt ccttttgata tagagaaaga taatgtggat
     6181 ttttgtatgg catctgctca aaaaggactt caagcgatga caggtctttc ttttattata
     6241 ggcaatgagg aacagattaa gttttcaaaa aaatatccca agcgttctta ctattgtaat
     6301 ctttatttgc agtatgagaa ttttgagaga acaggtgaaa tgcattttac tccaccggta
     6361 caaactattt acgccactcg tcaggcatta aatgaatatt ttgaagtggg cgaagaagct
     6421 aagtttgccc gtcacaaaag agtttttgag gctattcatt caggtataaa tgaaattggt
     6481 cttaaaagtg taataaagcg tgaatggcag tcaggactgg ttgtctcagt tcaataccca
     6541 gaagatccca actgggattt tgagaaaata catgattatt gttatgagcg tggatttacg
     6601 atttatccag gtaagatatc aactgaggat acttttagaa tctgtgcttt aggagagata
     6661 gaagtagatg atattgagaa cttctttaaa gtactaaaag ctgcattaaa tcattataac
     6721 gtcacattac cgatgtcatg attgcagaaa tattattgaa gattcgtcat ttttattttt
     6781 cccttcgtgg tatacacttc catccggaaa gtgttatttc tggagtgcct attcgtagct
     6841 ttcgcttagt aggcaaatat agcaatatct atttgggtaa aaatgctgaa atacgttcag
     6901 gctgttatct gattgctcgt gataaaatca ttattggaga aaactcaaca ctcgcctatg
     6961 gaacgactat attgacaact gctgatccta atggaccgta taatgcatta gcaattcttt
     7021 atccttataa aaaggcaccg gtagttatag gagataatgt ttggattggg gctaatgtta
     7081 ccatccttcc tggaataact attggtgatt acgttgtagt agcagctgga tctgttgtaa
     7141 caaaagatgt accttcaggg gtattggttg ctggtgtacc agctgttgtg aaaaaacagc
     7201 ttttgatgga ataagaataa ttgttttatt cttattgtca gacaatatca ttacataaga
     7261 agtataattt aatgcctcaa taatgaaaga taaaacttgt catataataa cagatgataa
     7321 tataaaagaa atagaattat ctatattgaa atatattgat ttacaatgta aaaagtacaa
     7381 tctaaggtat tatttgggat atggtacttt attgggagca gtgcgtcatc aaggtttcat
     7441 tccttgggat gacgacattg atatctggat gccacgggag gattatgaca aatttataag
     7501 tttagaaaat tcattggaaa actcaaagtt taagatttta tctcctttga acaattcaga
     7561 ttattattat ggatttgcta aactagtatc aagaaataca gaacttcagg aaataggatt
     7621 tcttcctatt aaggattatg gtgtatatgt ggatattttt cctttggata atattgcaac
     7681 ggagcatccg tttttacatt tcatagctaa atatataata atggcaagga ttgcgtcttg
     7741 taatataaaa ccttggttaa atctgacgca taagaaaaaa gctattttat ttcgctttat
     7801 aggaataatt gggacattgt taggatttcg aagaacagca aaattaacgg ataagatagc
     7861 taaaatagat aagggtaaaa cgaataaaag ggtgggggtc tttgttgaaa gcataggaga
     7921 gcataatata tttgcaacag aatattttgc ttctacaata cagttgaaat ttgagggaat
     7981 atattttaat gctccaaagg aatatcgaaa atgtttgact cagctttatg gagattatat
     8041 gcaactacct cccgaaaata gacgcatttc tggtcattca tttaaagcat gttacagatt
     8101 atgaaactaa caacatatgt tcttaattta ttgaaagata aagaacgaaa agaatatatg
     8161 caatatgtat tgagcgatta tcctaatcta gatattcaat atgttaatgc aataaatgga
     8221 aaaaatctta gtctggatga gatattgaat caatttgata ataataaagc atacaaacgc
     8281 tatggaagag aatgtgattt aggagaaatt gggtgcagtt tgagtcatcg attggcgttt
     8341 gatttattaa tgaattcgga gagtaactat gctttaattt tagaagatga tattgttatt
     8401 ggggatggat ttagtagcgt attggaaaaa ttattgccat tgattgatat cgatgctcct
     8461 tgtgttattt tattgtcagg tggtgtctct tattataaaa aaagatatta taatactttg
     8521 tgtttgggtg tagtttatat gggagattat gcgcatagtt atttaataaa taaggctgct
     8581 gctaaattaa tattggatga taaaaaagcg tatatatttg ctgatgattg ggattatata
     8641 cgtaatagag gagtaaatgt actagttatt ttacctcatt tagttgatca acgtagagat
     8701 ggaagttttg taagtaatgt ttggcaagat aatcaccata ttgtgaaggt gaaattatca
     8761 ttgattaggt tgtgtaacta tattctttca aggataatag ataaaatatt gaagcgaatg
     8821 ggaaattatg agaataagac actgtagtat ggttgaatca cgttctaaaa aaggtatagc
     8881 aaatataaaa tgttctttgt ttttttatat cgtaaactta tttcttaata ttatatctag
     8941 aaaggtcttt atcgattatt taggaataga agtactagga cttaacacaa cagttactaa
     9001 tctgcttagt tttctaaatt tggcagaatt gggaattggt aacgcaattg catttacttt
     9061 atataaacct ttatttttga aagattttca agttataagg gagatagtgt ctgttcaagc
     9121 ttggctttat cgacgaattg catattttat atctataggt gctttaggac taatgttgct
     9181 ttttcctgta atttttaaaa aaatagattt acctttgtgg tatgcttatg ctacatttat
     9241 tgttttattg atagcttctt tgttgagcta ttttgtgaat tataaacaga tacttctaag
     9301 tgcagatcaa aaagaataca aaataacact ttgtgtacag ggaataaaat cattaaaaac
     9361 cataacacaa gtggttgtta tattatatct aataaatggg tatgtgtatt ggttaactct
     9421 tgaacttgtg ggggtattgg tttcagcttt gctattaaat aaaattgtaa acaaagaata
     9481 tccttggttg tttgtaaagg tctctgatgg aaaaaaatta cgtaataaat atccagaaat
     9541 aatagtaaag acaaaacagt ttttttttca tcgcatctca tcatttgttt taaatcaaac
     9601 tagtccattg ataatctatg cctttgctag tcttacaatg gtagcaatct atggaaatta
     9661 tatgttgata gtttttggtg gaatagctct ggtaaatgct ttttttaatg gtttcaatgc
     9721 tggagtggga aatcttgttg ctgaaggaga taagaaaaaa ataaaatctt ttttttggga
     9781 aataacttct tttcggatat ggatagcagc catcatttgt gtctgttttt ttaagttgtg
     9841 tcatcctttt atttcattgt gggtgggaaa ggaatatgtt ttggatgaaa tgacctttat
     9901 agtgttaact atttatgttt ttatatcatt aacaagagta aatgaagctt ttctatttgc
     9961 ttatggatta tatcaggata tatgggctcc tataattgaa gctatattaa acttgggact
    10021 ttcggtttta ttgggattta tttggggact aacaggaata atatctgggg ttgttattag
    10081 tttagttgtc attgtatgta tatggaaacc atatttttta tttaaaatgg gtttcaaaga
    10141 taatatatta gaatatgtct ctagatatat aaaatattat atgatgattg ctttatcttt
    10201 tattttgtca catttaattc ttaatacaat gtttatagac ttccaaagtt catattggaa
    10261 gctttttgaa tatgcttgta ctgttggaag ctgttatgct atattgagtt ttctcttttt
    10321 ttatttattt gataatggga tgagacaatt tactagacgt ttattaaata tatttctaaa
    10381 ataatttagt gataaggtgt agttgttata tttagttttt agctgaaata gattttgtct
    10441 tgtattataa aaaatgagtt tttatatatt tatttttgtt gttttgctgt atttctcttt
    10501 taggaaatat aataaatata tttattgggg aactatttta ttactttcat tgatagcagg
    10561 gttgaggtcc gaaacgatag gagttgatac tcacgcttat aaagatatat ttatatggat
    10621 atcaaatgaa gtattatatc cgatagaacc tgcatggtat ttttttaata aattgattgc
    10681 ttgggtgggg ggaagtttta atttcttgtt gtggataact gcactattga ctttaatacc
    10741 aataggtgta gttagtttac gatgtagcag taatcctcag atgagtttgt ttttttacta
    10801 tggattatat gcatatatta attcatttaa tggaatgaga cagtttgttg ctatttcatt
    10861 tgtattatta gcttattctt atatcacaca aaagaagaat ttttttttgt atttactaat
    10921 tgcattcata ttccattatt cagcgatttt ttctttcatt gctattttgg tagataaggt
    10981 atcattaact aaacgacgtg taattggtgg tattttttct agtttttttg taggtatgtt
    11041 ttttaatgat tctatgtttc tagttttggc tggtccttat gcaggttatt tagaatcttc
    11101 tgagggatat agggataatt ttttattggc tgctataatg gcaattttga tgagttgttt
    11161 atatatgtgt acgtttttta ctttacgaag agaatataaa caaaatttgt ggacaaaaat
    11221 gttttttgtt ggcattatta tattgaatat aactatgcgg ttagaattag gagctcgtat
    11281 tattttgtat ttcacattat gccaaattat attttaccca atgtatttcc gtcataatat
    11341 tgtcaaaaat aaaagaatgg ttgttttgag tattttattg tatacttcgt tggtttttat
    11401 gaaaatatta attttgggta atcaaggaga atattctgtc tatccttata aaacaatatt
    11461 atggtaagca ttattattcc ttgttacaat tcgggaaaat atatttctga atgtttaaat
    11521 tctattttag ctcaaacata ttctgaatgg gaagcaattt gtgttaatga tggtagtact
    11581 gataatacaa tggaatttct gaatcaatat gtaatgtcgg ataatcgata taaagtagtt
    11641 tctcagctta attcaggagt gtcagcagca agaaataagg ctttatctat atgcaggggg
    11701 gaatatattt gctttgtaga tagtgatgat atagtagaac c
//
