LOCUS       gnlProkkaPMCAFLPO_75   13650 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PMCAFLPO_75.
ACCESSION   gnlProkkaPMCAFLPO_75
VERSION     gnlProkkaPMCAFLPO_75
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 15:03:10
            Original ID  :: gnl|Prokka|PMCAFLPO_75
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13650
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13650
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3299:3650]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3300..3650
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..13650
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13650
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             309..1820
                     /locus_tag="ctg75_1"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIENEPIASIDLMERAATVLTKAITDRWNT
                     ETPVTIFAGPGNNGGDALAVARMMAEKGYKIEVFLFNTKGELSPDCQTNKELVEMMEEV
                     KFHEISTQFVPPALTPDHLVIDGLFGSGLNKPLSGGFAAVVKYINSSPAMVVAIDIPSG
                     LMGEENTFNVKANIIRADVTFSLQLPKLAFLFAENTEFVGEWEVLDIQLSEDGIEEMET
                     NYEMLEIEQIRSLIKPRKQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPMCNNDILQTSIPEAIVETDINETCFAVPTDTDDYQAVGIGPGLGRNEETEAALLEQ
                     LEHCQTPVVVDADALNILANHRHTLTHLPKGSILTPHPKELERLTGKCQDSYERLMKAC
                     ELARAAHVHIILKGAYSAIITPEGKCFFNPTGNPGMATGGSGDVLTGVILALLAQGYPT
                     EEAAKIGTYIHGLAGDVAQKKQGMIGMIASDIITCLPTAWRLVSE"
     CDS             1893..2960
                     /locus_tag="ctg75_2"
                     /transl_table=11
                     /translation="MKKLIIAAGLLMTTSAYAQTEVLTGVTRGKDYGVVYSLPKTQIEL
                     EIKANKVNYTPGEFSKYADRYLRLTNVSADPEEYWELASVKVKSVGVPNSETTYFVKLK
                     DKTVAPLMELTEDGIVKTINVPYSNSSVGKKAAPAPTVLQKKANPREFLTEEILMASST
                     AKMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNAQEEAMTQMFSGTCN
                     KEERTFTVRLTPDKEFNNEVAFRFSKKLGVVANNDLAGTPFYISLKDLKSVKIPQEDGK
                     KKKDLDGIAYNVPGQAMVTLTDGKKKLYEGELPITQFGVIEYLAPVLFNKNSTIKVYFD
                     PNTGGLLKVDREEGK"
     CDS             2997..3281
                     /locus_tag="ctg75_3"
                     /transl_table=11
                     /translation="MVGEGHAFDMIRRIKEGREASRLRRERANDKLKHLNRANEPYPLP
                     NTTPEEMERIIHDSEKKKEKDSNYFVWGTLIIMGVLIAIAVILWAVFIK"
     CDS             complement(3300..3650)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg75_4"
                     /sec_met_domain="PqqD_RRE (E-value: 4.1e-11, bitscore:
                     34.4, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.5e-17, bitscore: 55.6,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAKEKINLLEVIPCRSEHITAEREGETIVLSFPRFKYPWMQRFL
                     VPKGMSKELHVKLEEHGTAVWELIDGKRNVREIIEKLADHFQNEEGYESRVSAYLSQMQ
                     KDGFIKLVIPVA"
     CDS             complement(3748..5136)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 92.3; E-value: 4.1e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg75_5"
                     /transl_table=11
                     /translation="MTEHLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AISTTFPEGAMLFGFKTQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDESGTFHTNIPAPILFCLIMLCVGTIAFFLYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMIIGSVMLIFVHTMFAL
                     PILNIWWFATIIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNTYCKGPVVDGAQTYDYTLPMTIFALFGVLALIVALMLKAENKKKGYGLEEA
                     NIQK"
     CDS             complement(5384..5779)
                     /locus_tag="ctg75_6"
                     /transl_table=11
                     /translation="MYLLFVILMVIAALLMCFIVLIQNSKGGGLASGFSSSNAIMGVRK
                     TTDFLEKATWGLAIFMVVMSIATAYVVPRSAVAKDAVLEQAQKEQQTNPYNLPAGTAAP
                     QTEAPATNAPATETPAPATETPAPAAE"
     CDS             complement(5786..6559)
                     /locus_tag="ctg75_7"
                     /transl_table=11
                     /translation="MTSVNFQQWIQHPETLNRDTLYELRNLLARYPYFQSLRLLYLKNL
                     YILHDISFGGELRKAVLYIADRRQLFRLIEGDRYDVQARKKGVPLTEVLKDEPSVDRTL
                     ALIDAFLSTVPEEVTARTSFDYSMDYTSFLLEETPATEQPAEETPKLKGFELIDDFIEK
                     SESDSPLCMKPLREEMPSSPTSSDELTEEETMKEEEEDDSCFTETLAKIYVKQQRYSKA
                     LEIIKKLSLKYPKKNAYFADQIRFLEKLIINANSK"
     CDS             complement(6565..7092)
                     /locus_tag="ctg75_8"
                     /transl_table=11
                     /translation="MNWIKKIIRPLLLFGLPLVVIACTVSYKFNGSSINYDKVKTISIA
                     DFPIKSEYVYAPLATKFNEDLKDIFIRQTRLQLLKPNQNADLQIDGEITGYNQYNQAVS
                     ADGYSSETKLTITVNVRFVNNTNHAEDFEQQFSAFRTYDSTQLLTAVQDGLIAEMSKEI
                     TDQIFNATVANW"
     CDS             complement(7079..8320)
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 387.1; E-value:
                     2e-117)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg75_9"
                     /transl_table=11
                     /translation="MTKAEIQQVKQRFGIIGNTEALSRAIDVAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EADGGTIFLDEVGELPMPTQARLLRVLESGEFIKVGSSKVQKTDVRIVAATNVNLTQAI
                     AEGRFREDLYYRLNTVPIQIPPLRERGDDVLLLFRKFSADFAEKYRMPAIQLTEDAKKE
                     LLAYPWPGNVRQLKNITEQISIIETNREISAAILQNYLPAQNTQRLPALMGTRESKGFE
                     SEREILYSVLFDMRQEVAELKKMVHNLMAERAGQVGQVGQMGTVVTTPVVTAHQPSVPA
                     IIHTMQPTVCKDDDDIQDTEEYVEESPLSLDEVEKEMIRKALERHHGKRKSAAKDLNIS
                     ERTLYRKIKEYELD"
     CDS             complement(8329..9423)
                     /locus_tag="ctg75_10"
                     /transl_table=11
                     /translation="MEDNKIRIGITQGDINGVGYEVILKTFSDPTMLELCTPIIYGSPK
                     VAAYHRKALDIQTNFSIVNSATEAGYNRLSVVNCTDDEVKVEFSKPDPEAGKAALGALE
                     RAIEEYREGLIDVIVTAPINKHTIQSEEFSFPGHTEYIEERLGNGDKSLMILMKNDFRV
                     ALVTTHIPVREIATTITKELIQEKLMIFHRCLKQDFGIGAPRIAVLSLNPHAGDGGLLG
                     MEEQEVIIPAMKEMEEKGILCYGPYAADGFMGSGNYTHFDGILAMYHDQGLAPFKALAM
                     EDGVNYTAGLSVVRTSPAHGTAYDIAGKGLACEDSFRQAIYVAIDVFRNRQRERVARAN
                     PLRKQYYEKRDDSDKLKLDTVDED"
     CDS             complement(9428..10468)
                     /locus_tag="ctg75_11"
                     /transl_table=11
                     /translation="MKKYFFILCIALVAFVVASCGLKGNHTSSGRAYELLVVVDHGVWD
                     RAAGRALHDALDSDMPGLPQSEPSFRIMYTSPKDYDSTLKLIRNIIIVDIQDIYTKASF
                     KYAKDVYASPQMILTIQAPNEEEFEKFVEENKKTIVDFFTRAEMNRQITFLEGKHSNFI
                     SQKVDSLFGCDIWVDAELANSKTGDDFFWASTNTGTADRNFVMYSYPYTDKNTFTKEYF
                     VHKRDSVMKANIPGFKEGVYMSTDSLLTDVRPINVQNSYTMEARGLWRMKGDFMGGPYV
                     SHTRLDEKNQRIITAEIFVYSPDKMKRNLVRQMEASLYTLKLPNEVQQNQIPLGGVSKE
                     AEQTKK"
     CDS             complement(10488..11522)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg75_12"
                     /sec_met_domain="PF04055 (E-value: 1.3e-18, bitscore: 59.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKYPLLGMTLVELQSLAKRLGMPGFTAKQIASWLYEKKVPSIDD
                     MTNLSLKHRELLKQNYEVGAEAPVDEMRSVDGTVKYLYKVGENHFVESVYIPDDDRATL
                     CVSSQVGCKMNCKFCMTGKQGYTANLTASQIINQIHSLPERDKLTNVVMMGMGEPLDNL
                     DEVLKALELLTATYGYAWSPKRITLSTVGLRKGLQRFIEENDCHLAISLHSPLPVQRSE
                     LMPAEKAFSITEMVELLKNYDFSKQRRLSFEYIVFKGLNDSQVYAKELLKLLRGVDCRV
                     NLIRFHAIPGVDLEGADMDTMTRFRDYLTSHGLFTTIRSSRGEDIFAACGMLSTAKQEE
                     NNES"
ORIGIN
        1 gggcaggaat taaactactg agagcgaaga ttatttattc acaatagaag aagtaccacc
       61 aaatttgacg aagaaccaga aatctttttc agggagaaat aaaagtaagt tcataatggt
      121 gcagcattga attatttttt ggcggagtta ttctaacact taatagttca aaagcagata
      181 tttctttgac caaaagatag aactaatgat gaattaaaag ttgcaattat ggttttcttc
      241 ccacaacaaa cgggaaaagt cagaagaatc atgtacattt gtaatccgaa aactaaaaga
      301 acatcgcaat gaaaatattt ccaagcagca gtatcaagaa attggacgct tataccattg
      361 agaacgaacc tattgcatca atcgatctga tggaacgtgc agcaaccgta ttaacaaaag
      421 ccatcacaga cagatggaat acggaaacgc cggtcactat ctttgccgga ccggggaata
      481 atggcggaga cgctctcgcc gtagcccgca tgatggctga aaaaggatat aaaatcgagg
      541 tatttctctt caacacgaaa ggagaacttt cacccgactg ccagaccaat aaagaactgg
      601 tagaaatgat ggaagaagta aaattccacg agatcagtac ccaattcgta cctcccgccc
      661 tgacgcccga ccatctggta atcgacggat tattcggttc aggcctgaac aaaccgttaa
      721 gcggcggatt cgctgccgta gtgaaataca tcaattcctc ccctgctatg gtagtagcca
      781 tcgacattcc ttccggactg atgggagaag aaaacacatt caacgtaaaa gctaatatta
      841 tccgtgccga cgtaactttc agtctgcaac tgccgaagct cgcctttctt ttcgcagaga
      901 acacggaatt tgtcggagaa tgggaagtgc tggacatcca attaagcgaa gacggtattg
      961 aagagatgga aacgaactac gaaatgttgg aaatagagca aatccgttca ctcatcaagc
     1021 cacgcaaaca gtttgcccac aaggggaact tcggccatgc actattgatt gccggttcaa
     1081 aaggaatggc aggagcctct gttcttgctg cccgcgcctg cctccgttcg ggagtaggat
     1141 tactgactgt tcatgcacca atgtgcaaca acgacatctt gcaaacctcc atacccgaag
     1201 caatcgtaga aaccgacatc aacgaaacct gttttgccgt acctaccgac acggacgact
     1261 atcaagcagt cggcatcggt ccgggactgg gacgaaacga ggaaacggaa gctgccttgt
     1321 tggagcaact ggaacactgc cagactcctg ttgtagtgga tgccgacgct cttaatatcc
     1381 tcgccaacca ccgccatacc cttacccacc tgccgaaggg ttccatcctc accccgcatc
     1441 cgaaagaact ggaacgtctg accggcaaat gccaggactc ttacgaacgt ctgatgaagg
     1501 cttgcgaact ggcccgtgcc gcccatgtcc acattatttt aaaaggagcc tactccgcca
     1561 ttatcacccc agaaggtaaa tgtttcttca acccaaccgg aaatccggga atggcaaccg
     1621 gaggtagcgg tgacgtactg accggagtaa tcctggcgct gcttgcccaa ggttatccca
     1681 ccgaagaagc cgctaaaatc ggcacttaca ttcacggatt ggcgggcgat gtcgctcaaa
     1741 agaagcaagg aatgatcgga atgatcgcaa gcgatattat cacctgtctg ccgacagcat
     1801 ggcgacttgt aagcgaataa aagttaagaa cttacagttt tttcaataac ttcattaact
     1861 ttgttttcaa aaccagttaa aaagaaccga atatgaaaaa gttgattata gcagcaggac
     1921 tacttatgac aacgtccgcc tatgcacaaa ccgaagtact gacaggggtt acccgaggaa
     1981 aagactatgg agtggtttac agtcttccca aaacccaaat agaacttgaa ataaaagcca
     2041 acaaagtcaa ctatactccg ggagaattca gcaaatatgc tgatcgttac ctgcgactga
     2101 ccaacgtctc cgccgaccct gaagagtact gggaactggc tagcgtaaaa gtgaaatccg
     2161 taggtgtgcc caacagcgaa acgacgtatt tcgtaaaatt gaaggataag acagtagcac
     2221 cgctcatgga actgacagag gatggcattg tgaaaacgat caatgttcct tacagcaaca
     2281 gcagtgtagg caaaaaagcc gctcccgctc ccacagtcct ccaaaagaaa gcaaatcctc
     2341 gtgaattcct gaccgaagag attctgatgg ctagctctac cgccaagatg gccgaactgg
     2401 tggctaaaga aatctataac atccgcgaaa gcaaaaatgc cttattgcgc ggacaggctg
     2461 acaatatgcc ttcagacgga gcacagctta agattatgct cgacaatctg aatgcacagg
     2521 aagaagccat gacgcaaatg ttctccggca cctgcaacaa ggaagagaga acattcactg
     2581 tccgccttac ccctgacaag gaatttaaca atgaagttgc tttccgcttc tcgaagaagt
     2641 taggtgtagt tgccaacaat gatttggcag gaactccgtt ttatatcagt ctgaaagacc
     2701 tgaaatcggt caagatacca caggaagatg gtaagaagaa gaaagatttg gatggaatcg
     2761 cctacaacgt acccggacaa gctatggtta cattgaccga cggcaaaaag aaactttacg
     2821 aaggtgaact tcctattact caatttggtg tgatagaata tctggctccg gttttgttca
     2881 acaagaattc taccatcaaa gtttattttg atccgaatac gggaggattg ctcaaagtgg
     2941 acagagaaga agggaaatag aaaaacgaga aagtgaactt ctaaaaaaca aagaatatgg
     3001 ttggtgaagg acatgcattc gacatgatac gccgaataaa agagggacgg gaagcttccc
     3061 gcctacgtcg tgaacgtgct aacgacaagt tgaagcattt aaaccgtgca aacgaacctt
     3121 atccactacc caacaccact cccgaagaaa tggaacgtat catccacgac tcggagaaaa
     3181 agaaagagaa agacagcaat tattttgttt ggggaacgct tattatcatg ggagtcctga
     3241 tagcaattgc cgtcatactt tgggctgtat ttatcaaata aataataata aattcctatt
     3301 tatgcgactg gtatcaccag ttttataaat ccatctttct gcatttgaga aagataagcc
     3361 gatacacgcg actcgtagcc ctcttcattt tgaaaatggt ctgcgagttt ttctataatc
     3421 tcacgaacat tgcgttttcc atctatcagt tcccatacag ccgtaccgtg ttcttccaat
     3481 ttcacatgaa gttctttcga cattcctttc ggcacaagga agcgttgcat ccacggatat
     3541 ttaaaacggg gaaaggagag cacaattgtc tccccttccc tttctgctgt aatatgttca
     3601 ctgcgacagg gaatgacctc taacaggttg attttctctt tggcagccat acttcttatt
     3661 ttttatttca gagtattcat actgataccc ttttgtttac accttgatac aaaattcctt
     3721 tgttacttta ggtattgaat ttcccagtta cttttggata ttcgcctctt ccaaaccgta
     3781 tcccttcttc ttgttctctg ccttcaacat caaagccaca atcagagcaa gcacaccaaa
     3841 aagagcaaaa atagtcatcg gcaacgtgta gtcataagtc tgtgcaccgt ctactaccgg
     3901 acctttgcaa taagtattca acacccatcc gatcaacaaa ggaacaccca tcaatcccca
     3961 gttctgtacc cagaaaatca atgcgtatgc tgtacccaac tgtttttccg gaataatctt
     4021 cggaacagac ggccacatag ctgaaggcac caacgagaag gcaaatccca atataatcat
     4081 gataatagta gcaaaccacc atatattcag tataggcaga gcaaacatcg tatgcacaaa
     4141 aataagcatc actgatccga ttatcatcaa cgtagctccc ttaccgatac ggtcataaag
     4201 cgagccgaac aacggagtca gaataatcgc accaatcggc aacaatccgg gaatcgttcc
     4261 cgccaacttc ggatctacgt tatatttctg caccatcaag tcggcagcat acttgataaa
     4321 ggggaataca gccgagtaga acaatacaca tagtaatgca atcaaccaga atcctttatt
     4381 ggtaatgata tacacaatat ctttcatacg gaacggttct tccggttcca atccctctgc
     4441 atccaaagaa gcatccaact tcttatcata gaaagtataa aggaaaaaag caatcgtacc
     4501 cacgcacaac ataatcagac aaaacaaaat cggagcagga atatttgtat ggaatgtgcc
     4561 actctcatcc gtagatccga aaaagtctgc caaaggaact gtcaatacca tcgccagagt
     4621 tgttccgata cgtgccgtag ccatttcaag tcccatagcc aatgccattt ccttgccctt
     4681 gaaccatttc actataatct tggaaacagt gataccagca atctccacac ctacaccaaa
     4741 gatagcatat cccaatgcag ccaacgtcac ctgtgttttg aatccgaaga gcatggcacc
     4801 ttccggaaaa gtagtagaaa tcgcatagta tttcaatcca caaccaaaca ccatcaataa
     4861 gcaagctccc attccggtga aacgaactcc cattttgtcc aaaatgatac caccgaagat
     4921 cagcatcaac aagaatacgt taaaccaacc gtaagcgctt gtgaagaatc cataatcaag
     4981 actatcccat aatagttctt tctcaagcat gggttttaga ggagacatta cgtcggtgag
     5041 gaaatagccg catagcatag taaatgcgac caatgctaga acactccatc ggagtacggc
     5101 ggagtcattc aatttctgtt tcaaatgttc tgtcattgtt atatttaaaa aagtagttaa
     5161 taatcttata cagccaacaa aggtagttaa atctcgtttg tttctatcac aaagagattg
     5221 tttttacaag aaaaagttaa gtgcggatta cactgaccac gcggaacatt gaaaatccgt
     5281 gtaatctgcg taatccgcac ttaaatatca aagaaatgca gcatccgtct gcaccttccc
     5341 attaatggtt ttaccccaaa gtcttacctg acgacggagt gaattactct gctgcaggag
     5401 caggagtttc agtagccggt gccggagttt ctgtagcagg tgcattggta gcaggagctt
     5461 cagtttgcgg cgcagccgta cctgcgggta agttatacgg gttagtctgt tgttctttct
     5521 gtgcctgttc caacactgcg tctttagcaa cagcagagcg aggaactaca taagcagtag
     5581 caatgctcat tacaaccata aagatggcca ggccccatgt tgctttttcc agaaagtctg
     5641 tagtcttgcg cacgcccatg atggcgttag atgaagagaa accagaagca agtccgcctc
     5701 cttttgagtt ctgaatcagc acgatgaaac acatcaacaa ggctgcaata accattaaga
     5761 taacgaataa taagtacatt tttagttatt ttgaattagc gttaataatc aatttctcca
     5821 aaaatctgat ttggtctgca aagtaagcat ttttttttgg atatttcaag cttaattttt
     5881 taattatttc aagagctttt gaatatcgtt gctgtttaac atagattttt gccaaagttt
     5941 ccgtaaaaca gctgtcatct tcctcttctt ccttcatcgt ttcttcttcg gtaagttcgt
     6001 ccgaagaggt tggcgaagat ggcatttctt ctcttaaagg tttcatgcag aggggagagt
     6061 cgctctcgct cttttctata aagtcgtcaa tcagttcgaa gcctttgagt ttgggcgttt
     6121 cttcagccgg ctgttccgtg gccggagtct cctccaaaag gaaagaggtg taatccatcg
     6181 aatagtcgaa actggtccgg gcagtcacct cttcgggtac tgtggacaag aaagcgtcga
     6241 tcaatgctaa tgtgcggtct acggacggtt cgtctttcag cacctccgtg agaggtactc
     6301 cctttttccg tgcctgcaca tcatagcggt caccttcaat caaccggaac aactgccgtc
     6361 tgtctgcaat gtaaagaact gctttccgca gttctccacc gaaactaata tcatggagaa
     6421 tatacagatt cttcagatac agcagacgaa gtgactgaaa atacggatac ctcgcaagaa
     6481 gattgcgcag ttcgtacaaa gtatccctat tcagcgtctc gggatgctga atccattgtt
     6541 gaaagttaac agaagtcatt tatattacca gtttgctaca gttgcattaa aaatttgatc
     6601 ggtgatctct ttagacattt cagcaatcaa tccgtcctgt acggcagtca gcaactgggt
     6661 agagtcgtag gtacggaacg cagaaaactg ttgttcaaag tcttcggcat gattggtgtt
     6721 gttgacaaaa cgcacattga cggtgatagt caacttcgtc tccgaagaat aaccgtcggc
     6781 agatactgct tggttgtact gattgtatcc tgtgatttct ccgtcaatct gcaagtcggc
     6841 attctgattc ggcttgagca gttgcagacg ggtctgccgg atgaagatat ctttcaagtc
     6901 ctcattgaat ttggttgcta acggagcata tacatactcc gacttgatcg ggaagtcggc
     6961 tatcgaaatg gtctttacct tatcataatt gatagacgat ccgttaaact tataggaaac
     7021 agtgcacgca atgactacca acggcaagcc gaacagtaac aaagggcgta ttattttctt
     7081 aatccaattc atattctttt atttttctat aaagtgtacg ctcggaaata ttcaagtcct
     7141 tggccgcact cttccgcttt ccatgatgcc tctcaagtgc tttgcgtatc atttctttct
     7201 ccacttcatc cagtgacaaa ggagattctt ctacatattc ttccgtgtct tgtatgtcat
     7261 catcatcctt gcaaaccgtg ggctgcatgg tatgaataat agcaggtacc gaaggttgat
     7321 gcgccgtcac taccggagta gtaaccaccg ttcccatttg tcctacctgc cccacctgtc
     7381 cggcacgttc cgccatcagg ttgtgcacca tcttcttcag ctccgccact tcctggcgca
     7441 tatcgaacag aacagaataa agaatctccc gttcgctctc aaagccttta ctctcacgcg
     7501 ttcccatcaa tgcgggaaga cgttgcgtat tttgtgcagg aagataattc tgcaagatag
     7561 cagcagagat ctccctgttg gtttcaatga tagatatttg ctcggtgatg ttcttcaact
     7621 gacgaacgtt gccgggccac gggtaagcca ataactcttt cttcgcatcc tccgtcaact
     7681 ggatagcagg catccggtat ttctctgcaa agtctgcgga aaacttacgg aacaacaaaa
     7741 gtacatcgtc accacgttca cgcaaaggcg gtatttggat aggcaccgta ttcaaccggt
     7801 aatataaatc ttcacggaaa cgtccttctg caatcgcttg tgtcagattg acattggtag
     7861 ctgccacaat acgaacatcc gtcttttgca ctttggacga acctactttt ataaactcgc
     7921 cactctccaa cacacggagc aaacgcgcct gggtaggcat cggcaactcc cctacttcat
     7981 caaggaaaat agtaccaccg tcggcttcgc caaagtaccc tttccgttcg ccaatcgcac
     8041 cggtaaacgc acccttctca tgcccgaaca gttcggaatc aatcgtaccc tccggaatag
     8101 cgccacagtt gacagcgata tactgtccgt gcttcctccg gctatattga tgaataatct
     8161 gcggaaaact ttcttttccg actccacttt ctccggtaat cagcacagac aaatcggtag
     8221 gagctacctg aatggcaaca tctatggcgc gcgacaatgc ttcagtatta cctataatac
     8281 cgaaacgttg tttcacttgt tgtatctctg cttttgtcat tacttgtttt aatcttcgtc
     8341 tactgtatcc agtttcagtt tatcactatc atcacgtttc tcgtaatact gtttacgcaa
     8401 cggattggca cgagccactc tttcccgctg acgattacgg aacacgtcga tggcaacata
     8461 aattgcctga cggaaagaat cttcacaagc cagtcccttg cctgcaatgt cataagcagt
     8521 gccatgagcc ggagaagtac gtactaccga cagacctgcc gtatagttta ctccatcttc
     8581 catagccaat gctttgaacg gagccagtcc ctgatcgtga tacattgcca ggataccgtc
     8641 aaaatgagta taattgcctg aacccataaa gccatcggcc gcataaggac cgtagcaaag
     8701 gattcctttc tcttccattt ctttcatggc agggataatc acttcctgct cttccattcc
     8761 caacaaacca ccgtctccgg catgaggatt gagagagagc accgcaatac gcggagcacc
     8821 gatgccgaaa tcctgtttca gacaacgatg gaatatcatc agtttctcct gaatcaattc
     8881 tttggtaatc gtagtcgcaa tctctctgac agggatatga gttgttacca aagccacccg
     8941 gaaatcattc ttcatcaaaa tcatcaatga tttatcaccg ttacccagac gttcttcgat
     9001 atattccgta tgtccgggga atgagaactc ttccgactga atcgtatgtt tgttgatcgg
     9061 agctgtcacg ataacgtcta tcagcccttc gcgatattct tcgatggcac gttccaaagc
     9121 tcccagcgca gctttgccgg cttcgggatc gggtttggaa aattccactt tcacttcatc
     9181 atccgtgcag ttcactacgc tcaaacggtt gtagcccgct tcggtagcag agttgacaat
     9241 actgaaattg gtctgtatgt ccaacgcttt acgatgataa gccgctactt taggtgaacc
     9301 gtaaatgatc ggagtacata attccaacat tgtagggtca gaaaatgtct tcagaatcac
     9361 ctcatagccc accccgttaa tatctccctg ggtgataccg attcttatct tgttatcttc
     9421 catgttttta ttttttagtt tgttccgctt ccttggacac tcctcccaat ggaatctgat
     9481 tctgctgaac ttcattcgga agtttcagtg tataaagaga ggcttccatc tggcgtacca
     9541 ggttgcgttt cattttatca ggtgaataaa caaatatttc tgctgtaata attcgttggt
     9601 ttttctcgtc cagacgagta tgagatacat acgggccacc cataaagtca cccttcatac
     9661 gccacaaacc acgtgcttcc attgtatagc tgttctgtac attgatcgga cggacatcag
     9721 tcagcaaact atcggtcgac atataaacac cttccttgaa tccggggata ttggctttca
     9781 tcacggagtc acgtttatgc acaaaatatt ctttggtaaa cgtattcttg tccgtatacg
     9841 gataagagta catcacaaag ttgcggtcgg cagtccccgt attagtagaa gcccagaaga
     9901 aatcatctcc agtctttgaa ttagccagtt cggcatccac ccagatgtcg catccgaaca
     9961 aactatccac tttctgcgaa atgaagttac tatgtttccc ttccaggaaa gttatctgac
    10021 ggttcatttc cgcacgggta aaaaagtcaa caatcgtctt tttgttctct tccacaaact
    10081 tctcgaactc ttcttcgttc ggagcctgga tagtcaatat catctgcgga ctggcataca
    10141 catccttcgc atatttaaat gaggctttcg tatatatgtc ctgtatatct acaatgataa
    10201 tgttacgtat caacttcagc gtagaatcat agtctttcgg tgaagtatac ataatccgga
    10261 aagagggctc cgactgcggc aaaccgggca tatcggaatc gagcgcatca tgtaaagccc
    10321 ttccggcagc acgatcccaa acaccgtgat ctactacaac caaaagctcg taagcacgac
    10381 cactagaggt gtgatttcct ttcagaccac aagatgcaac gacaaaggct accaaagcga
    10441 tgcataaaat aaaaaagtac tttttcatga tgttcggttt ttatatatta actttcatta
    10501 ttttcctcct gtttcgctgt cgacaacata ccgcaagcag caaaaatatc ttctcctctg
    10561 gacgaacgga tggtggtgaa aagcccgtgt gacgtcagat aatcacgaaa acgggtcatc
    10621 gtgtccatgt ccgctccctc aaggtctacc cccggtatgg catgaaaacg aatcagattc
    10681 accctgcaat ccactcctcg aagaagtttc agcaactctt tggcatagac ctgcgaatca
    10741 ttgagccctt taaaaacaat atattcaaac gaaagtcgac gttgtttact aaaatcatag
    10801 ttttttaaca gttccaccat ttcggtgatt gaaaacgcct tttccgccgg cattaattcg
    10861 gaacgttgaa caggcagagg agagtgaaga ctgatggcaa ggtggcaatc attttcttcg
    10921 ataaaacgct gcaatccttt ccgtagtccg actgtagaaa gcgtgatacg cttcggactc
    10981 catgcgtaac cgtaggtagc ggtaagtagt tccaatgctt tcagcacttc atccaggtta
    11041 tcgagcggct cgcccattcc catcattacg acattggtca gtttatcccg ttccggcagc
    11101 gaatgaatct ggttaatgat ctggctggcg gtcaggttag cggtataacc ttgtttgccg
    11161 gtcatacaga acttacagtt catcttgcag cccacttgtg aagacacgca caacgttgcc
    11221 cggtcatcat ccggtatata aaccgattcc acaaaatggt tctcacccac cttataaaga
    11281 tacttcaccg taccatctac agagcgcatt tcatctaccg gagcttccgc tcccacctca
    11341 tagttttgct tgagcaactc ccggtgtttt aatgacaaat tagtcatatc atcaatcgag
    11401 ggcaccttct tttcgtaaag ccaagatgca atctgcttgg cagtaaagcc gggcataccc
    11461 agtcttttag ccaatgattg aagctctaca agggtcattc ctaaaagggg atatttagac
    11521 attcttcttt ctgttcatgg tttatatttg caaatgtaag gaaataaagt cgatttccgt
    11581 atagcgggaa tgtaaaagtt aacaaaaaag gaaagtatgc ctccgttatg attcaaccac
    11641 gctgatatat tgaagtagct tttgcgccac ttcagagtcc tttccattct ttttcacttc
    11701 atgaccgtac gcctcacgga aacaagccag cgcctcttcc cgttcattac aaaagctatg
    11761 caaaacccct aagttctgac aagccagaat cgtatcttct tcctcccatc ccaaatactt
    11821 ctttcgcagt tcaagctctc tgaagaaagc ctctttcgcc attggataat tctccaactt
    11881 cacataagcc tgtgctttgt aataatatac cagacaggaa gcattagggt cagcatcatc
    11941 gtgaaaatcc aaagacgttg caatacgaat cacgttatca tagtctttat tcatgtaata
    12001 ctgctgcata atatcacatc tcaatgcctc gtagcggaca gtcaattccg ccagacgcgg
    12061 tttttcgctg aaatacattt catgcagaag agactcacgg aagaataaag tagacacctg
    12121 ctcatcgcca cgttcattca tcactcgttt gaattccctg cacagataat acaactgttt
    12181 atgacaagcg acgatctgtt ttttgctatc tatctgtata gcaatgtcca acgcctgatt
    12241 cattagcatc catgcttcat cgtatcgttt gatataataa agacatttac cctgcatacg
    12301 caaacattta gccactccac cagacagtct gccattcaac gactcgtgca tttcagctac
    12361 tttccggaat ttctcggcag cactctcttc ctcatcctta tagtaatcac aataagccag
    12421 atattcggaa agttcaatga cttctgcctg actcttctcg tcagcagaag ccgcatgata
    12481 atcaagcgcc ctattcaaat agatcgccgc ttcattgtat tgctcattgt agtaatatgc
    12541 caaagctaga tttcgacagg tgttggcaat ctccagttcc ggagtcggta ctatgttttc
    12601 ctgcatcacc aatgctttca ggaaacagtc gcatgccgtt tcgtattctt cattacgggc
    12661 ataccgacat ccctcattca tcttcaatac cgacttggca atgagtggca tggcagcacc
    12721 ttccatactc ttctcactca cagcagctgc cgccttcgtc agatggaaag aactgctcaa
    12781 gaaagtagcc atatcattag caatgacagg aattaaaaaa gaatcgatct catcaaagtc
    12841 caattcggca tagacttcag gcgtaacttc aggattgtcg ttcatgatcg ccttccagct
    12901 atcttccaac agaaaacgat tcgtgcgata cagaatctcg aaaatctcca catcacaaat
    12961 ccaatccttc aatatatccc attcttgcat cttatagcat tgataggtaa tctccacttt
    13021 atagcgatac gaatcatggt agcagaactg tttcatgcga tagttataat cggcaaaagt
    13081 caacggatgg gaaaggattt cttcctcatc cagcagagcg gaaataattt catggcgact
    13141 atcatctata cattcgtcat cttgagcgaa atagcgttcg atcgcctcta ccatttgtgt
    13201 atcaccaatg caatatcgtc ctcctttgtt ggtgagccag ctgctcattt ccactctcaa
    13261 ctgcgaccaa agtatctgat taatgtctgc catgctcttc acttcatctt cggtaaatcc
    13321 ttctaaagta agtgaaagca tcagaagcgt tcttccaatc tcttcggaac cataatcagc
    13381 cgacaaacgc cgtagcacac tgtcatagaa ttgcccaacc tcattgagcc ggcaatatcc
    13441 acgcatatat tcattgagag catcgtactg accgaacgaa accagctcgt tgagcaatac
    13501 acttaaacag cgcggttgtt cagccagcac ccacgaagca agaatatctt cctgctgtgc
    13561 agacaaagcc ttggagtaag tagacaaata ttgctttgag aacgacttgg catccgcctg
    13621 tgaaaagcca ttcaactgga aatgagcgta
//
