LOCUS       c00015_gnlPro..        16322 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IEEEPCDK_15.
ACCESSION   c00015_gnlPro..
VERSION     c00015_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 14:11:08
            Original ID  :: gnl|Prokka|IEEEPCDK_15
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16322
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16322
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2770:6322](+)"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2771..6322
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="5000"
                     /detection_rule="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /neighbourhood="10000"
                     /product="PFOR_II_pathway"
                     /protocluster_number="1"
     cand_cluster    1..16322
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(POR and POR_N and PFOR_II and EKR and
                     Fer4_16 and TPP_enzyme_C)"
                     /kind="single"
                     /product="PFOR_II_pathway"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16322
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="PFOR_II_pathway"
                     /region_number="1"
                     /rules="cds(POR and POR_N and PFOR_II and EKR and Fer4_16
                     and TPP_enzyme_C)"
                     /tool="gutsmash"
     CDS             complement(198..1397)
                     /locus_tag="ctg15_1"
                     /transl_table=11
                     /translation="MTKKALYIFNPEHDLALASGETNYMAPASARQMASELALLPMWYA
                     EEGSVVLAPSAYNLDYVKKIQELLGLSVDLMTEPELASERNLDIRPWGWDIAIRKRLLD
                     LGVEESELPSIEQLDKLRFCSHRSCAVGLLPQLQLGACFCGESFYLTFPEEWKSFVESH
                     DTCLLKAPLSGSGKGLNWCKGVYTPSISGWCSRIGKQQGGVIGEPLYNKVEDFAMEFRS
                     SSNGRFGFAGYSQFRTGGSGAYEGNLLISDAAIERNLLEYIPVEEIYKLRDRLEQELSL
                     RFGTIYNGYLGVDMMICRFPESPVYRIHPCVEINLRMNMGVVARHIYDHYIYPTSTGAF
                     QISYYPTEGTAWRAHKEMEEAYPLEIEQGRIKSGYLSLVPAHKKSSYRAWVFISKSVFL
                     "
     CDS             1560..2738
                     /locus_tag="ctg15_2"
                     /transl_table=11
                     /translation="MESFYRTHAYLVEHTNAPVRRDLMDEIDWSDRLIGIKGTRGVGKT
                     TFLLQYAKEKFGNDRSCLFINMNNFYFSGHSIVDFANEFQKRGGKVLLIDQVFKHPEWS
                     KELRMCYDRFPNLKIVFTGSSVMRLKEENLELRDIAKSYNLRGFSFREYLNLQTGMKFR
                     AYSLEEILSTHEQIAKGVLSKVRPLDYFQDYLHHGFYPFFLEKRNFSENLLKTMNMMVE
                     VDILLIKQIELKYLSKIKKLLYLLAVDGPKAPNVSQLASDIQTSRATVMNYIKYLADAR
                     LINLVYPKGEEFPKKPSKIMMHNSNLMYSIYPVKVEEQDVLDTFFVNSLWKDHKVHKGD
                     KNVSFMVDEVMPFKICQEGAKIKNNPNVTYALHKAEIGRGNQIPLWMFGFLY"
     CDS             2771..6322
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: TPP_enzyme_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: Fer4_16"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: EKR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PFOR_II_pathway: POR_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_3"
                     /sec_met_domain="PFOR_II (E-value: 5.5e-18, bitscore: 57.9,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 6.3e-82, bitscore: 267.4,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 6.3e-31, bitscore: 100.4,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.3e-11, bitscore:
                     37.2, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_16 (E-value: 2.2e-11, bitscore: 37.3,
                     seeds: 227, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_6 (E-value: 3.5e-08, bitscore: 26.0,
                     seeds: 134, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 0.00017, bitscore: 14.8,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 1.1e-24, bitscore: 78.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQKKFITCDGNQAAAHISYMFSEVAAIYPITPSSTMAEYVDEW
                     AAAGRKNIFGETVLVQEMQSEGGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAG
                     EFLPCVFHVSARTLASHALCIFGDHQDVMSARQTGFAMLAEGSVQEVMDLAGVAHLATI
                     KSRVPFMNFFDGFRTSHEIQKIEMLENDDLAPLIDQEALAEFRARALNPMNPVARGMAE
                     NPDHFFQHRESCNNYYEAVPAIVEEYMNEISKITGRKYGLFDYYGAEDAERVIIAMGSV
                     TEAAREAIDHLVANGEKVGMVAVHLYRPFSAKHFLAAVPKTAKTIAVLDRTKEPGANGE
                     PLYLDVKDCFYGAENAPVIVGGRYGLGSKDTTPAQILSVFENLAMPMPKNHFTIGIVDD
                     VTFTSLPQKEEIALGGEGMFEAKFYGLGADGTVGANKNSVKIIGDNTDKHCQAYFSYDS
                     KKSGGFTCSHLRFGDTPIRSTYLVNTPNFVACHVQAYLHMYDVTRGLRKNGSFLLNTIW
                     EGEELAKNLPNKVKKYFAQNNISVYYINATQIALEIGLGNRTNTILQSAFFRITGVIPV
                     DQAVEQMKKFIVKSYGKKGEDVVNKNYAAVDRGGEYKTLAVDPAWANLPDDAKAENNDP
                     AFINEVVRPINAQDGDLLPVSAFKGIEDGTWYQGTSKYEKRGVAAFVPEWNPENCIQCN
                     KCAYVCPHASIRPFVLDAEEQKGAKFEQLKAVGKVFDGMTFRIQVDVLDCLGCGNCADI
                     CPGNPKKGGKALTMKHLESQLAEADNWTYCAENVKTKQHLVDIKSNVKNSQFATPLFEF
                     SGACSGCGETPYVKLISQLFGDREMVANATGCSSIYSGSVPSTPYTTNENGHGPAWANS
                     LFEDFCEFGLGMELANEKMRARIVKLFNEILAADNASPEAKEVLKAWIENMYDADKTKE
                     LAPQVKAVIEEGLSHGCPICKELKGLTQYLVKRSQWIIGGDGASYDIGYGGLDHVIASG
                     KDVNILVLDTEVYSNTGGQSSKATPVGAIAKFAAAGKRVRKKDLGLMATTYGYVYVAQI
                     AMGADQAQTLKAIREAEAYPGPSLIIAYAPCINHGLKAGMGKSQEEEEKAVKCGYWHLW
                     RYNPALEEEGKNPFQLDSKEPNWEDFQGFLKGEVRYASVMKQYPTEAEELFKAAEENAK
                     WRYNSYKRLARENWGAE"
     CDS             complement(6475..7341)
                     /locus_tag="ctg15_4"
                     /transl_table=11
                     /translation="MRIYKIVGIVLSAMLLLASCTNSDLEKKKVKIAYANWLEGIAMSH
                     LAKVVLEEHGYEVELQNADLAPIFVSMSGKKSDVFLDAWLPITMKDYMDQYGDSIEFFG
                     EVYGEARVGLVVPQYVTIHSINELEANKDRFSSEIVGIDAGAGIMKTTDKAIAAYGLDG
                     YTLMTSSSSTMLASLKKAMDKGEWIVITGWTPHWMFDQFDLKFLDDPKKVYGDLEEIHA
                     IAWKGFSEKDPFAAEFFGNIKLTTEELSSFMTAMKDARMDEEEIARKWRDEHRLLVDSW
                     IPKSENK"
     CDS             complement(7362..8186)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_functions="transport (smcogs)
                     SMCOG1004:Binding-protein-dependent transport system inner
                     membrane component (Score: 92.9; E-value: 6.9e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg15_5"
                     /sec_met_domain="BPD_transp_1 (E-value: 1.1e-28, bitscore:
                     92.9, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINIGQYIEMAINWMMIHFSTFFDAVNAGIGSFIIGFQHILFGIP
                     FYITILVLAALAWMKAGRGTAIFTALGLLLIYGMGFWEATMQTLALVFSSTCLALIVGV
                     PLGVWTANSSRAEKILRPVLDLMQTMPAFVYLIPAVLFFGLGAVPGVFATIIFAMPPVV
                     RLTGLGIRQVPKNVVEASRSFGATRWQLLYKVQLPLALPTILTGVNQTIMMSLSMVVIA
                     AMIAAGGLGEIVLKGITQMKIGLGFEGGIAVVILAIILDRITQGMAGRKNKN"
     CDS             complement(8183..9409)
                     /locus_tag="ctg15_6"
                     /transl_table=11
                     /translation="MSKIEIKDLYLIFGNEKQKALKMLKKDKSKEEILKDTGCTVGVKD
                     ANLSINEGEFFVIMGLSGSGKSTLLRCINRLIRPTTGQVLVNGVDISKISEKELLQVRR
                     KELAMVFQNFGLLPHRSVLSNIAFGLELQGVKKEEREKKAMESMKLVGLKGYENQMVGE
                     LSGGMQQRVGLARALANNPEVLLMDEAFSALDPLIRVQMQDELLALQSKMKKTIVFITH
                     DLSEAIKLGDRIAIMKDGEVVQVGTSEEILTEPANDYVARFVENVDRSKIITASSLMID
                     KPLVARLKKEGPEVLIRKMRAKNITVLPVIDADDKLVGEVRLNDLLKLRSKQEKSIETI
                     VRTEVHSVLEDTVLEDILPLMTKSNSPVWVIDETREFLGTIPLSSLIIEVTGKDKEEIN
                     EIIQNAIDL"
     CDS             complement(9708..10046)
                     /locus_tag="ctg15_7"
                     /transl_table=11
                     /translation="MKDYKVDKASLSASFCQEVYQVVREIPVGKVSTYGGIAALLGMSQ
                     CSRMVGRALKQIPDDLSAPCHRVVNASGRLVPGWTEQKQLLLEEGISFKQNGCVDLKKH
                     LWNYSVPE"
     CDS             10130..11425
                     /locus_tag="ctg15_8"
                     /transl_table=11
                     /translation="MQLYLLYLQIIPTFVPIKSNPIINKTSTAVMKKKTILFASCLLGA
                     LAFSSCEKNLYDESKQPEKEKKMTDLEVPADFDWKGSQNAKVKIASQSTATISVFLEEN
                     CNEEALMLRMDVDANTSKLELPIEIPAYIKNVYVKYGNGSEIQTVPVESNGTISIVVPA
                     NATALSRVTTRANKEVETNNIFNYPGYGNGTIMFEDMYPALGDYDFNDFVAWYNFQIDG
                     FYWSHNQCYAEYLMIGFQIRAIGGIYDYNPYIRLAEVQYNELDLEETQMYLERNNPEEA
                     ENIKILKGPKGELIISLKKPAIPNGYKYYNTEVNEKTKPKKMMAIYLVFNSPVNVKSLQ
                     DSKMDFYIAKTNKGQEIHLKGYSPVYYNSNESYVNEDNFIWGLKVPASLHHAREEVNFL
                     EAYPDFEQWVTSGGQENQRWWNKPKTNKLIMN"
     CDS             complement(11567..14449)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peripla_BP_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:Periplasmic binding proteins and sugar binding
                     domain of LacI family (Score: 62; E-value: 2.1e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg15_9"
                     /sec_met_domain="Peripla_BP_1 (E-value: 3.3e-19, bitscore:
                     62.0, seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIEAMKYMKWITVLFCLLGLAACRQDAPRFRIGVAQCSDDSWRHK
                     MNDEILREAMFYDGVSVEIRSAADDNRKQAEDVHYFIDKGVDLLIISANEAAPMTPIVE
                     EAYQKGIPVILVDRKILSDKYTAYIGADNYEIGRAVGNYIASSLKGKGNVVELTGLGGS
                     TPAMERHQGFMAAISNYPDIKLIDKADAAWEREPAEVEMDSMLHRHPKIDAVYAHNDRI
                     APGAYQAAKKAGREKEMIFVGIDALPGKGNGLELVLDNVLDATFIYPTNGDKVMQLAMN
                     ILEKKSYPRETVMNTAVVDRTNAHVMQLQTTHISELDQKIETLNGRIGGYLSRVATQQV
                     VMYGGLVILLLVAGLLLVVYKSLRSKNRLNKELSEQKKQVEQQRDKLEEQRDILEEQRD
                     KLEEQRDQLIQLSHQLEEATHAKLVFFTNISHDFRTPLTLVADPVEHLLADSSLSEDQR
                     RMLLLVQRNVNILLRLVNQILDFRKYENGKMEYTPISLDILSSFEGWNESFMAAARKKH
                     IHFSFDYMPDTDYRTLADVEKLERIYFNLLSNAFKFTPENGKVTVRLSSLTKDDHCWIR
                     FTVANTGSMISAEHIRNIFDRFYKIDMHHAGSGIGLALVKAFVELHKGTITVESDEKQG
                     TIFTVDLPVQTCETVVSENSPAFSVPATSVTSTDAATSAVAGAPVTPATSGYSGSSSLN
                     DALTYEEEELEKSYDSSKPCVLIIDDNADIRLYVHGLLHTDYTVIEAAYGSEGIRKAMK
                     YVPDLIISDVMMPGMDGIECCRRLKSELQTCHIPVILLTACSLDEQRIQGYDGGADSYI
                     SKPFSSQLLLARVRNLIDSHRRLKQFFGDGQTLAKEDVCDMDKDFVEKFKALIEAKMGD
                     SNLNVEDLGKDMGLSRVQLYRKIKSLTNYSPNELLRIARLKKAASLLASSDMTVAEIGY
                     EVGFSSPSYFTKCYREQFGESPTDLLKRKG"
ORIGIN
        1 ttaggtttta aaaaatattg agtaaactaa cttaggtata acaagcgaag ttgtcaacta
       61 aatccagtac agtacacaca tggcatgtga ttacttgttt catgcaatga aactttttgt
      121 ttctcggtgt ggaaccaatg gtttcactac atgaaactat cagtttcaca ccgagaaacc
      181 ataacttcga tataatatca caaaaacacg ctttttgaga taaacaccca cgcccgataa
      241 ctactctttt tatgagccgg caccaatgac aaatagcctg attttattct tccttgttct
      301 atttccaaag gataagcctc ctccatttct ttgtgtgctc tccaggctgt tccttccgta
      361 gggtaatagc ttatttgaaa agctcctgtt gaagtaggat agatataatg gtcataaata
      421 tgacgcgcta ctactcccat attcatcctc aagttgattt ccacgcaagg atgaatccga
      481 taaacaggag attctggaaa gcgacagatc atcatatcca ctcccaaata accattataa
      541 atggttccga aacggaggga taattcttgt tcaaggcggt cgcgcaattt ataaatttct
      601 tcgacaggga tatattccaa aagattccgt tcgatggctg catctgaaat cagcagatta
      661 ccttcgtacg ccccacttcc acccgtacgg aattgagagt atccggcaaa gccaaatcga
      721 ccattactcg aagaacgaaa ttccatagca aaatcttcca ccttattata tagaggttcg
      781 ccaataacac ctccttgctg tttgccaatg cgtgagcacc aaccggaaat agaaggagta
      841 tatacacctt tgcaccagtt cagccctttc ccgctaccgg ataaaggagc tttcagtaaa
      901 caagtatcat gtgattctac aaatgacttc cattcttcgg gaaacgtcag gtaaaaagac
      961 tctccacaaa aacaggctcc cagttgtagc tgtggtaata atcccacagc gcaggaacga
     1021 tgggaacaga aacgcagttt atccaattgc tcaatagaag gaagctcgct ttcttccact
     1081 cccaaatcca acagtcgttt tcttattgct atatcccagc cccaaggacg aatatccaaa
     1141 ttccgctccg aagcaagttc aggttctgtc atcaaatcaa ccgaaagtcc taataattcc
     1201 tgtatcttct tcacatagtc gagattataa gcggaaggag ccaatacaac acttccctct
     1261 tctgcatacc acatcggcaa caaagccaat tcggatgcca tctgccgggc ggaagccggt
     1321 gccatatagt ttgtttcacc gctggctaac gccaaatcat gttccggatt gaatatataa
     1381 agagcctttt ttgtcatttt aaacgaattc aaaactttat tctgcaaata tatacaggaa
     1441 atagtcagga atggctacaa taaacagaaa gttctaatta aactcacaat tttgccatct
     1501 ctactttgca aatcctaaaa aaagcagtat atttgccacc cgaaaaacaa agaactgaaa
     1561 tggaatcatt ctatcgcaca cacgcctacc tcgttgagca caccaatgcc cccgttcgcc
     1621 gcgatcttat ggacgagatc gactggagcg accgcctgat tggtatcaaa gggacacgtg
     1681 gcgtaggaaa aaccactttc cttctccaat acgccaaaga aaaatttggg aacgaccgct
     1741 cctgcctgtt catcaacatg aacaacttct acttctctgg ccacagcatt gtagactttg
     1801 ctaacgaatt tcagaaacgt ggcggaaaag tattgttgat cgaccaggtg ttcaaacatc
     1861 cggaatggag caaagagtta cgcatgtgtt acgaccgttt tcctaacctg aaaattgtct
     1921 tcaccggctc gtccgtgatg cgactgaaag aagaaaatct tgaattacgt gatatcgcca
     1981 agagctataa cctgcgcgga ttttcttttc gcgaatacct gaacttacag acaggcatga
     2041 aattcagggc atacagcctc gaagaaattc ttagcactca cgaacagatt gccaaaggag
     2101 tactctctaa agttcgtccg ctggattact tccaggatta cctgcatcat gggttctatc
     2161 cgttcttcct cgagaagcgt aacttctcgg agaatttgct gaaaacgatg aacatgatgg
     2221 tggaagtaga tatacttctc atcaaacaaa ttgaactgaa atatctttca aagataaaaa
     2281 aattactata tttgctcgct gtcgacgggc cgaaagctcc aaatgtgagc caactggcaa
     2341 gcgacataca gacatctcgc gccacggtga tgaactatat caagtatctg gcagatgcgc
     2401 gactcattaa tctggtttat ccgaaagggg aagaattccc taaaaaacct tcgaagataa
     2461 tgatgcacaa ctccaacctg atgtattcca tctacccggt gaaagtggag gagcaggatg
     2521 tgctcgacac tttctttgtg aattctttat ggaaagacca taaggtacat aaaggagata
     2581 aaaacgtctc ttttatggtg gacgaagtaa tgccgttcaa aatttgccag gaaggagcaa
     2641 agatcaagaa caatccgaat gtgacgtacg cgttgcataa ggctgaaata ggtcggggca
     2701 accagatacc tctctggatg ttcggctttt tatattaaaa gatttattta cttaaatatt
     2761 taatttagtt atgactaaac agaagaaatt catcacttgt gatggtaacc aggctgcagc
     2821 gcatatctcg tatatgttct ctgaagtagc tgctatctac cccatcactc cttcttcgac
     2881 tatggctgag tacgtagacg aatgggctgc cgcaggacgt aagaacatct tcggcgaaac
     2941 agtattggta caggaaatgc aatctgaagg tggtgctgcc ggtgcagttc acggttctct
     3001 tcaggctggt gcgttgacta ctacttacac tgcttctcag ggtcttctcc tgatgatccc
     3061 taacatgtac aaaattgccg gtgagttctt gccttgcgta ttccatgtat ctgctcgtac
     3121 attggcttct cacgcattgt gtatcttcgg tgaccaccaa gacgtaatgt cagctcgtca
     3181 gactggcttt gcgatgttgg ctgaaggctc tgtacaggaa gttatggatt tggctggtgt
     3241 tgctcacttg gctactatca aatctcgtgt tccgttcatg aacttcttcg atggtttccg
     3301 tacatctcac gaaatccaga agattgaaat gttggaaaat gatgatcttg ctccgctgat
     3361 tgatcaggaa gctttggctg aattccgtgc ccgcgcactg aatccgatga atccggttgc
     3421 tcgtggtatg gctgaaaatc ctgaccattt cttccaacat cgtgaatcat gcaacaacta
     3481 ctatgaagca gttcctgcta tcgtagaaga atacatgaat gaaatttcta agattacagg
     3541 tcgtaaatac ggtttgttcg attattatgg tgcagaagat gcagaacgcg taattatcgc
     3601 tatgggttct gtaacagaag ctgcccgcga agctatcgac cacttggtag caaatggcga
     3661 aaaagtgggt atggttgccg tacacctgta tcgtccgttc tctgctaaac acttcctggc
     3721 tgctgtacct aagactgcca agactatcgc agttcttgac cgtactaaag aaccgggcgc
     3781 taacggcgaa cctctttacc ttgacgttaa agactgcttc tacggcgcag aaaatgctcc
     3841 ggttatcgtt ggcggtcgct acggtttggg ttcaaaagat actactcctg ctcaaattct
     3901 ttcagtattc gagaacttgg ccatgccaat gccgaagaat cacttcacta tcggtatcgt
     3961 agacgacgtt actttcactt ctcttcctca aaaagaagaa atcgctttag gcggtgaagg
     4021 aatgttcgaa gctaaattct acggtttggg tgctgacggt acagtaggtg ctaacaagaa
     4081 ctctgtaaag attatcggtg acaacactga caaacactgc caggcttact tctcttatga
     4141 ctctaagaag tcaggtggtt tcacttgttc tcacttgcgt ttcggtgata ctccgatccg
     4201 ttccacttat ttggtaaata ctccgaactt cgttgcttgt cacgttcagg cttacctgca
     4261 catgtacgat gtaactcgtg gtttgcgtaa gaacggttct ttcttgctga acactatctg
     4321 ggaaggtgaa gaactggcta agaacctgcc taacaaggtt aagaaatatt ttgcacagaa
     4381 caacatttcc gtatactata tcaacgcaac acagattgca ttggaaattg gtttgggtaa
     4441 tcgtaccaac actatccttc aatctgcatt cttccgtatc acaggtgtta ttcctgtaga
     4501 ccaggctgtt gaacagatga agaaattcat cgttaagtct tacggtaaga agggtgaaga
     4561 cgttgttaac aagaactatg ctgccgttga ccgtggtggt gaatacaaga ctttagctgt
     4621 tgatcctgct tgggctaacc tgccggatga tgcaaaagct gaaaacaacg atcctgcatt
     4681 catcaacgaa gtagttcgtc cgatcaatgc acaagatggt gacttgctgc ctgtatctgc
     4741 attcaagggt atcgaagacg gtacttggta tcaaggtact tctaaatacg aaaaacgtgg
     4801 tgtagccgca ttcgttcctg aatggaatcc agaaaactgt atccagtgta acaagtgtgc
     4861 atacgtttgt cctcacgctt ctatccgtcc gttcgtactc gatgctgaag agcagaaggg
     4921 tgctaagttc gaacaattga aagcagtagg taaagtattc gacggtatga cattccgtat
     4981 ccaggttgac gttctcgact gtctgggttg cggtaactgt gctgacatct gtccgggtaa
     5041 tccgaagaag ggtggcaaag cattgacaat gaaacacctc gaaagccaat tggctgaagc
     5101 tgacaactgg acttactgtg ctgaaaacgt gaagactaaa caacatcttg ttgatatcaa
     5161 gtctaacgtg aagaactcac agttcgctac tccgttgttt gagttctctg gtgcttgctc
     5221 tggttgtggt gaaactccgt atgtgaaatt gatttctcaa ttgttcggtg accgtgaaat
     5281 ggttgctaac gctaccggat gttcttctat ctactctggt tcagttcctt ctactccgta
     5341 tactacgaac gaaaacggtc acggtcctgc ttgggctaac tcactgttcg aagacttctg
     5401 tgaattcggt ttgggtatgg aattggctaa cgaaaagatg cgtgctcgta tcgtgaagtt
     5461 attcaacgaa atccttgctg ccgacaacgc ttcacctgaa gcaaaagaag tgctgaaagc
     5521 atggattgaa aacatgtacg atgctgacaa gactaaagaa ttggctcccc aagtgaaagc
     5581 agtgattgaa gaaggtcttt ctcacggatg tcctatttgc aaagaactga aaggactgac
     5641 tcaatatctt gtaaaacgca gccaatggat cattggtggt gacggtgctt cttacgatat
     5701 cggttatggt ggtcttgacc atgtaatcgc ttccggtaag gacgttaaca tcctcgttct
     5761 ggatactgaa gtttactcta acacaggtgg tcagtcttct aaggctactc cggtaggtgc
     5821 tatcgctaag ttcgctgctg ctggtaagcg cgtacgtaag aaagacctcg gtctgatggc
     5881 tactacttac ggttatgtat atgttgcaca gatcgctatg ggtgctgacc aagctcaaac
     5941 tctgaaagct atccgtgaag ctgaagcata tccgggacca tctttgatta tcgcttacgc
     6001 tccatgtatc aaccacggtc tgaaagcagg tatgggtaag agccaggaag aagaagaaaa
     6061 agctgttaag tgcggttact ggcacttgtg gcgttacaac ccagctttgg aagaagaagg
     6121 caagaaccca ttccaattgg atagcaaaga accgaactgg gaagatttcc aaggtttctt
     6181 gaagggtgaa gttcgttacg cttctgtaat gaaacaatat cctactgaag ctgaagaact
     6241 gtttaaagct gctgaagaaa acgctaaatg gcgttacaac agctacaaac gtttggctag
     6301 agaaaactgg ggtgctgaat aatagtaata ccctataaat ataaagcggt aatcttatca
     6361 aagattaccg cttttttatt gtatgaactc tgtccaacat aaacagtact ccctttttcc
     6421 cactagagtt catgtctatt ttatatttaa aattaagaat aacaatgctc caatctattt
     6481 attctctgac ttcggaatcc aactatccac caacagccga tgctcatccc tccatttacg
     6541 ggctatttct tcttcatcca tcctggcatc cttcatagct gtcataaaag agctaagttc
     6601 ttctgtcgtt agtttgatgt tgccaaagaa ttcggcagca aacggatctt tctcactgaa
     6661 tcctttccat gcaatagcat gtatttcttc caagtctcca tatactttct tcggatcatc
     6721 caagaatttc aagtcaaact ggtcgaacat ccaatgcggt gtccaccccg taatgacaat
     6781 ccattctcct ttgtccatcg cttttttcaa agaagccagc atggtggaac tacttgaagt
     6841 catgagggta tacccatcaa gtccgtaagc agcaatggcc ttatcggtcg tcttcattat
     6901 ccctgctccc gcatcaattc ctactatttc agaggaaaaa cggtctttat tagcttccag
     6961 ctcattaata gagtggatcg taacatattg aggaacaacc agtccgacgc gagcttctcc
     7021 gtatacctcc ccaaaaaatt cgatgctgtc tccatactga tccatataat ctttcatcgt
     7081 tattggtaac catgcatcca gaaacacatc tgatttcttt cctgacatag atacaaaaat
     7141 aggggcaaga tcagcatttt gcaattcaac ctcatatcca tgctcttcca ataccacctt
     7201 agccaaatga ctcatggcaa taccttccag ccaattggca taggctattt ttactttctt
     7261 tttctctaag tctgaattag tacaggaagc tagcaaaagc atagctgaca atactattcc
     7321 tactatttta tatattctca tacgtatttt atcctttccg tttagttctt attttttcgt
     7381 cctgccattc cttgcgtgat acggtctaag atgatagcta aaataacaac tgctatacca
     7441 ccttcaaacc caagtccgat tttcatttgg gtaatacctt tcaatacaat ttctcccaga
     7501 ccaccggcag caatcatggc agcaattaca accatagaaa gcgacatcat tattgtctgg
     7561 ttgacaccag tcagaatggt gggcaacgcc aaaggaagct gcactttata caataactgc
     7621 caacgggtag ctccgaacga acgggaagct tccactacat ttttaggaac ttgccggatt
     7681 cccaatccgg taaggcggac cacaggaggc atagcaaaga taatggtggc aaacactcct
     7741 ggcactgctc ccaatccgaa aaacaaaaca gcaggaatca gataaacaaa agcaggcatc
     7801 gtctgcatca agtcgagaac aggacggagt attttctctg cacgcgaact gtttgccgtc
     7861 catactccta aaggtacacc aacaatcagg gccagacagg tagatgaaaa aacgagagct
     7921 agagtttgca tggtagcctc ccagaatccc attccataga tcagtaataa tcccaatgcg
     7981 gtgaaaattg ccgtaccgcg tcctgctttc atccatgcga gtgcagcaag taccaaaatg
     8041 gttatataaa aaggtattcc gaaaagtatg tgttggaatc ctataataaa actaccgatg
     8101 cccgcattca cggcatcaaa gaaagtggaa aaatgtatca tcatccaatt gatggccatc
     8161 tctatatatt gtcctatatt tatcataaat ctattgcgtt ttgaattatt tcgtttattt
     8221 cttctttatc tttcccggtc acttcgatga ttaaggatga aagcgggatt gttcctaaaa
     8281 actcgcgcgt ctcatcaatc acccataccg gcgaattgct ctttgtcatt agaggaagta
     8341 tatcctccaa caccgtatcc tccaacacag aatgtacttc tgtacgcaca atcgtttcaa
     8401 tggatttttc ctgtttgcta cgtaacttaa gcaagtcgtt cagacgtact tctccgacca
     8461 gtttatcatc ggcgtctatg acaggtaata cggtgatatt cttcgcacgc atcttacgaa
     8521 tcaatacttc gggaccttct ttcttcagac gggccaccaa cggtttgtca atcattaaag
     8581 aagaggcggt aataattttg ctcctatcca cgttttcaac aaaacgggct acataatcgt
     8641 tagccggttc agtcaggatt tcctccgaag tacctacctg caccacttct ccgtctttca
     8701 tgatggcaat acggtcacct agcttaattg cttcactcaa gtcgtgggta ataaaaacaa
     8761 tcgtcttttt catctttgat tgcaaggcca gtagttcatc ctgcatctgt acgcgaatca
     8821 gaggatcgag agcagagaaa gcctcatcca ttaaaagcac ttcaggatta ttagccagag
     8881 cgcgagccag tccgacacgc tgttgcattc caccggaaag ctcgcctacc atctgatttt
     8941 catatccttt caatccgaca agcttcatgc tttccatcgc tttcttctca cgttcctctt
     9001 tcttcactcc ctgaagttcg aggccgaacg cgatattgct caatacggaa cggtgaggta
     9061 acagaccgaa attctggaaa accatcgcca gctctttccg acgaacctgc aataattctt
     9121 tttcggaaat tttagatata tctactccgt ttacaagcac ttgcccggta gtaggacgta
     9181 tcagacgatt gatacaacgc agtaatgtcg attttccact tcccgagagt cccattatca
     9241 cgaaaaactc tccttcatta attgaaagat tggcatcttt cactcctacc gtacaaccgg
     9301 tatctttcag aatttcctct ttactcttat cttttttcaa catcttgagg gctttctgct
     9361 tctcgttacc aaagataagg tacaaatcct ttatttctat tttactcata taatatattg
     9421 gtttagatta taatatttgt tttgttttca actgccgcat tccttattct cacttacgat
     9481 aaacaagttg aatgttcgca tggttcagtc atgtcacatg ataacatgac ggtccgacgt
     9541 tttttaaatg gttaaaaaaa acagacagag tagtttaaaa ggaatagaat ttgataagat
     9601 tatcctctta atgaacagta gaaaacagta ttttcataaa taaataacag tctgttcttg
     9661 catattgttg gcacaaaggt aaggaaaata gattaaatat gcaaatttca ttcaggtacg
     9721 gagtaattcc aaagatgctt tttcaagtct acgcatccat tttgtttgaa agagatccct
     9781 tcttccaaca agagttgttt ctgctctgtc caacccggaa caagccgtcc cgacgcattg
     9841 acaacccgat gacaaggcgc agataaatca tccggaatct gtttcaaagc acgccccacc
     9901 atacgggaac attgagacat tcccaataat gcggcaattc ccccataggt agaaacttta
     9961 cctaccggaa tttctcggac aacctgatac acctcttgac aaaaggatgc ggaaaggctc
    10021 gccttatcta ctttataatc tttcatcact caaacattac tttatttcag ttccaaaact
    10081 agataaaaag aaaagaattt gcaaataata aaagcatttc aaataaaata tgcaacttta
    10141 tttgctttat ttacaaataa tcccgacctt tgtacccatt aaaagcaacc ctattattaa
    10201 caaaacaagc actgctgtta tgaaaaagaa aactatcctg ttcgcttctt gtttattggg
    10261 agcactggct ttcagctcct gtgagaagaa cctttatgat gaaagtaaac aacccgagaa
    10321 agaaaagaag atgactgact tggaagtacc tgccgatttc gactggaaag gttctcaaaa
    10381 tgccaaagtg aaaattgcca gtcaatcaac tgctactatt tctgtatttc tagaagaaaa
    10441 ttgcaatgaa gaggctttga tgcttcgaat ggatgtcgat gccaacacat caaaattgga
    10501 actcccaatt gaaattcctg catatataaa aaatgtgtat gtaaaatatg gtaatggctc
    10561 tgaaatacaa actgttcctg ttgaaagtaa tggtactatt tctatagtag tacctgctaa
    10621 cgctacggca ttatccagag ttaccacaag agctaataaa gaagttgaaa cgaacaacat
    10681 cttcaattat ccgggatatg gcaacggaac tattatgttc gaagatatgt atccagcttt
    10741 aggcgattat gattttaatg attttgttgc atggtataat ttccaaattg acggttttta
    10801 ttggagtcac aatcaatgtt atgcagaata cttaatgata ggattccaaa tcagagctat
    10861 aggaggtata tatgactaca atccttatat ccgcttggca gaagtacaat ataatgaact
    10921 tgatttagaa gaaactcaaa tgtatcttga gcgtaacaat cctgaagagg ctgaaaatat
    10981 caaaatccta aaaggcccaa aaggggaatt gattatttca ctaaagaaac cggccattcc
    11041 taacggatac aagtattata atacggaggt aaatgaaaaa acaaagccta aaaaaatgat
    11101 ggccatttac ttggtgttca actcacctgt taacgttaaa agcctacaag acagtaaaat
    11161 ggacttttat attgcaaaaa ctaataaagg acaagaaatc cacttaaaag gttatagccc
    11221 ggtttattat aacagcaacg aaagttatgt aaatgaagac aactttatat ggggattaaa
    11281 agtacctgca tctttacatc atgccagaga agaagtaaac ttcttggaag catatccaga
    11341 ctttgaacaa tgggtaacat cgggaggtca agagaaccaa agatggtgga ataagccaaa
    11401 aacgaataag ttgattatga attaataaat atacagtaaa tcatatactg aattaaataa
    11461 gaggtaaggt atgtcaatag atttccttac ctcttatttt tatcatatga attccataga
    11521 agtataaaca gataaatgct caccaccaaa ttttgcagat tctatcctat cctttcctct
    11581 tcaacaaatc tgtcggactc tctccaaact gttctctata acatttagta aaataagaag
    11641 gagaactaaa accaacttca taaccgatct ctgccactgt catatccgac gaggcaagca
    11701 gagaggcagc tttcttcaaa cgagctatac gaagcagttc attcggagaa taattagtca
    11761 gagatttaat cttgcggtaa agttgcacac gacttaatcc catatcctta cccaaatctt
    11821 ctacattcaa atttgaatct cccatctttg cctcaatcag agctttgaat ttttccacaa
    11881 agtctttatc catatcacag acatcctctt tcgccaacgt ttgtccgtca ccaaaaaact
    11941 gtttcaggcg gcggtgtgaa tctatcagat tacgaacgcg tgccaatagt aattgcgaac
    12001 tgaaaggctt ggagatataa gaatctgcac caccatcata cccttgaatt cgttgttcat
    12061 ccaaagaaca agctgtcaat aggataacag gaatatgaca ggtttgtaat tcgcttttca
    12121 agcgacgaca acattcaatt ccatccattc cgggcatcat tacatcggag ataatcaagt
    12181 ccgggacata tttcatagct ttacgaatac cttccgagcc gtatgcagct tctataacag
    12241 tataatcagt gtgaagcaat ccatgcacat ataagcgaat atcagcgtta tcatcaataa
    12301 tcagaacgca aggtttggaa gagtcgtaac ttttttccaa ttcctcttct tcgtaagtta
    12361 aagcatcatt caagctcgaa gaaccggaat aaccagaagt tgcaggagtt acgggagccc
    12421 cagcaacggc agaggttgca gcatcggtag aggttacaga agtagcaggc acagagaatg
    12481 ccggagagtt ttctgaaaca acagtctcgc aagtctgtac aggcaaatca acggtaaaga
    12541 tagttccttg cttttcatca ctttccaccg tgatggtacc tttatgcaat tccacaaaag
    12601 cctttaccaa tgccagtcca atacccgaac cggcatggtg catatctatc ttatagaaac
    12661 ggtcgaaaat attccggata tgctccgcag aaatcattga gccggtattg gcaacagtaa
    12721 agcgaatcca acaatgatcg tctttagtca gggaagataa gcgtacagtt acttttccat
    12781 tctctggagt aaatttgaaa gcgttggaaa ggaggttgaa atagatgcgt tccaactttt
    12841 ctacatctgc caatgtgcgg taatccgtat ccggcatata atcgaatgag aaatgaatat
    12901 gtttcttccg ggctgctgcc atgaaagact cgttccatcc ctcaaaagaa gaaagaatgt
    12961 ctaacgaaat aggagtatat tccatttttc cattctcgta tttacgaaaa tccagaatct
    13021 gattgacaag acgcaagagg atattcacgt ttcgctgaac taacaataac attcggcgct
    13081 gatcttcact caaagacgaa tcagccagta aatgctctac cgggtcggca actaatgtca
    13141 gtggagtacg aaaatcgtga gatatatttg tgaagaaaac cagcttggca tgagtcgctt
    13201 cttccagttg atgagaaagc tggataagct gatcccgctg ttcttcgagt ttgtcacgct
    13261 gttcttcaag aatatcccgt tgctcttcga gtttatcgcg ctgttgctct acttgtttct
    13321 tctgttcgga caactcttta ttcaggcgat tcttggaacg gagggattta tagactacca
    13381 acaacaatcc cgctactaat aaaagaataa ccaagccgcc atacatcacg acctgctgcg
    13441 tagctacacg cgacagatac ccaccgatac gtccgttcaa tgtttcaatc ttctgatcca
    13501 gttccgagat atgggtagtc tgaagttgca taacgtgcgc gttcgtgcgg tctacaacgg
    13561 cagtattcat gaccgtttcg cgaggataag acttcttctc aagaatattc atggccagtt
    13621 gcatcacttt gtccccatta gtcggataaa taaaagttgc atccagcaca ttgtcaagca
    13681 ccaattcaag tccgtttcct ttgccgggca gggcatcaat gccaacaaaa atcatttcct
    13741 tttcacgtcc ggctttcttc gcagcctgat aggctcccgg agcgatacgg tcgttatgtg
    13801 catacaccgc atcaatcttc ggatgacggt gaagcatact atccatttcc acttctgccg
    13861 gttcacgttc ccaggcagca tccgctttat caatcagttt gatatccgga taattgctga
    13921 tagcggccat aaatccctga tggcgctcca tagcaggggt ggaaccaccc agtccggtaa
    13981 gctccactac attccctttc cctttcagac ttgatgcgat ataatttcct accgcacgac
    14041 ctatttcata attatcggca ccaatatagg cagtatattt atcagaaagt atcttccggt
    14101 ctacaagaat gacgggtatt cctttctgat aggcctcctc cacaattgga gtcatgggag
    14161 ccgcttcatt ggcggaaatt atcagtaaat caactccttt atctataaaa taatgaacat
    14221 cttccgcctg cttacggtta tcatccgccg ccgaacggat ttcaaccgac actccatcat
    14281 aaaacatcgc ttcgcgaaga atctcatcat tcatcttgtg ccgccaagag tcatcactac
    14341 attgggccac cccaatacgg aaacgaggcg catcctgacg acaggccgcc aagcccaaaa
    14401 gacaaaacaa gactgttatc cacttcatat atttcatcgc ttcaatcatt ccctttcttt
    14461 cgtatatctt ttgtatttct ttctgtaatc caaatttctc tccccgcatt atttgcattc
    14521 accaccggga aatacatcag ttccactttc acagggttca gcgtgtattt tccagtaaag
    14581 cgtgaaagca aaggaaccgt aaactgataa gtacctaccg gtaatttttc gctaaagata
    14641 acagttttct ctttaaaata ctcacgatac acttcagaac gggagaaatt aacaggtttt
    14701 gaggcataac tacaacctgc cggaacagga acttcgagca tcacatattg cgcaccctcc
    14761 tgtttcacct gcaaggtaac tgtcaatgta acaggtacac ccgccaccaa agagtctttt
    14821 tccaaagtcg cctccacctt gaaagcatca ctctgacgag cattcatcac acgcttcatt
    14881 gaatagacac tatacaataa aggctctttt cccgtttttg aaataagcag actgtcgcct
    14941 gctgtcagcc gggcatgata aggaaattcc gtaattcgtt gatgatcctt accgctcaca
    15001 aacaccgacg ttcctgacat ccctccggaa cctgccagca aatcggtcag aacagttgcc
    15061 acagccgaag aagcctgata cgtattccat ccgcgctcct tagtccgcaa aatatacaat
    15121 tgcatatttt ctttcaactt acacagggaa gggtcatttt taataatccg gtaggctatc
    15181 aatgtattta tcatctgatt tccctcccaa taataagtac gccgtccgtc gtcacagtaa
    15241 acaccttcca gcatatcctt tttcagataa ggacgtacgc tatcacccac attcaccgaa
    15301 tccacctgtt gcttgatttc ccagagaagc agcttctctt tcaagtatga aagaggacga
    15361 taatacttgt ttctatttgc caacgagtct tctttctgtt ccaattgccg gacgaaaggt
    15421 tccaataatc tgactgccga agaataatcc gcctctactt tccactcatg cagagcatga
    15481 agtatttcta tatcttccag tttcattcct cgataaggac gcgtatgagc atactccact
    15541 ttcaaaccat tcagattcaa ctccacagga taacctgcat cttgcgccat cttcaaagcc
    15601 cgcagaatat gcgcagacat ccagaaagaa gtattttcag agttccccca ccacgaccat
    15661 aactgatgtt tgttctgatg attcgtcagt cgatggatga taggtcgaat tgctttatct
    15721 actttcacct tttcaccctt actctgcata tactgttggt aagccaacaa accgattaac
    15781 ttggatgcca gctgctcatt gcacaaatat ttgtatcctg tcaagtaatt cactgattct
    15841 ttatagatgt ccaactgatt gtcagtgata ctcaccatca cttcttcatc ctcgccggat
    15901 tgcactttaa ccgtctttgc atcggacaga atacccaatg tgccctccgc caattcagtt
    15961 ccctgtgcca gtatcggaat cgtatattcc tctccatcct gatagccatc gtcgcgagtg
    16021 aaaagatagc tgatggtcac gctatcggca tgaactgcct gcatcggcac tgtttcatga
    16081 aatccctcca tgaaactcac ttcctgccgt ttcaacgtat ccgttccgac gcagaactgt
    16141 gtctttccgg ctatgtgctg cccatccaga taattgcgga tagtcccgac caccgtactc
    16201 tgatccccct ccaccaagaa gcggggagtt ttcaactccg ccatcaacgg tttgtaagag
    16261 cggacgaaac gtcggaaagt acccgtttgc aaacgacggt tcatgccata aacgacagtt
    16321 tc
//
